Immunomodulatory drug Lycopid. Medicine Lycopid contains glucosaminylmuramyl dipeptide, which binds to specific centers located in the endoplasm of T-lymphocytes and phagocytes. The drug Likopid stimulates the phagocytic activity of macrophages and neutrophils, enhances their bactericidal and cytotoxic activity. The drug increases the proliferation of B and T lymphocytes and stimulates the synthesis of specific antibodies. Lykopid enhances the production of tumor necrosis factor, gamma interferon, interleukin-1, interleukin-12 and interleukin-6, as well as colony-stimulating factors.
Glucosaminylmuramyl dipeptide also increases the activity of killer cells.
When taken orally, the bioavailability of glucosaminylmuramyl dipeptide is about 7-13%. The maximum concentration in blood plasma is achieved within 1.5 hours after administration. The half-life reaches 4.29 hours.
Excreted mainly by the kidneys.
Indications for use
Lycopid used in complex therapy of patients suffering from diseases accompanied by secondary immunodeficiency, including:Acute and chronic forms of purulent-inflammatory diseases of soft tissues and skin, including those that developed after surgical interventions.
Infectious diseases of various localizations caused by the herpes virus (including genital and oral herpes, ophthalmic herpes, etc.).
Chronic forms of viral hepatitis B and C.
Adults are also prescribed Lycopid for infectious lung diseases, pulmonary tuberculosis, psoriasis and infections caused by human papillomavirus.
Children are also prescribed Lycopid for chronic forms of infectious diseases of the upper and lower respiratory tract.
Mode of application
Lycopid Intended for sublingual or oral administration. To achieve the maximum therapeutic effect, glucosaminylmuramyl dipeptide should be taken 30 minutes before meals. The regimen and dose of the active substance is determined by the attending physician depending on the nature of the disease, concomitant therapy and the individual characteristics of the patient.When performing surgical interventions to prevent complications Lycopid, as a rule, is prescribed at a dose of 1 mg per day. The duration of the preventive course of treatment is 10 days.
For purulent-septic lesions of soft tissues and skin Lycopid, as a rule, is prescribed at a dose of 2 mg twice or three times a day. For more severe forms of purulent-septic lesions, the dose of the drug Lycopid can be increased to 10 mg per day. The duration of the course of treatment is 10 days.
For chronic infectious diseases of the lungs Lykopid, as a rule, 1-2 mg per day is prescribed. For pulmonary tuberculosis, the dose of Lykopid is increased to 10 mg per day. The duration of treatment for lung diseases is 10 days.
For an infection caused by the herpes virus, Lycopid, as a rule, prescribe 2 mg 1 or 2 times a day. In severe cases of herpes, the dose of Lykopid is increased to 10 mg 1 or 2 times a day. The duration of treatment is 6 days.
For ophthalmoherpes Lykopid, as a rule, 10 mg is prescribed twice a day for 3 days. After which they take a break for 3 days and repeat taking the drug again. The total course dose of the drug Lykopid for ophthalmoherpes is 120 mg.
For cervical lesions associated with papillomavirus, Lycopid, as a rule, 10 mg per day is prescribed. The duration of therapy is 10 days.
For psoriasis, Lykopid is usually prescribed 10 mg 1 or 2 times a day for 10 days, after which they take a 1-day break and resume taking the drug at a dose of 10 mg per day. For severe forms of psoriasis, Lykopid is prescribed 10 mg twice a day for 20 days.
Children under 16 years of age are prescribed Likopid 1 mg 1 to 3 times a day for 10 days.
For children under 16 years of age with viral hepatitis, Lykopid is usually prescribed 1 mg three times a day for 20 days.
Side effects
Lycopid, as a rule, is well tolerated by patients.In some cases, at the beginning of taking the drug Lykopid, the development of hyperthermia was noted, which does not require discontinuation of glucosaminylmuramyl dipeptide.
Contraindications
Lycopid not prescribed to patients with individual intolerance to glucosaminylmuramyl dipeptide.Likopid tablets should not be taken by patients with galactosemia, glucose-galactose malabsorption syndrome and lactase deficiency.
The drug is contraindicated for diseases and conditions that are accompanied by hyperthermia (body temperature more than 38 degrees Celsius), as well as during exacerbation of autoimmune thyroiditis.
Lycopid It is not advisable to use it to treat pregnant and lactating women.
In pediatric practice, only the drug Likopid is used, containing 1 mg of active substance per tablet. Glucosaminylmuramyl dipeptide should not be prescribed to children under 3 years of age.
Pregnancy
Lycopid not prescribed during pregnancy.During lactation, the drug can be taken only if breastfeeding is discontinued.
Interaction with other drugs
Co-administration of the drug is not recommended Lycopid with sulfonamides or tetracyclines.Lycopid when used in combination, it potentiates the effect of fluoroquinolone and cephalosporin antibiotics, as well as semisynthetic penicillins and polyene derivatives.
There is a mutual enhancement of the therapeutic effects of the drug Likopid and antifungal and antiviral agents when used in combination.
Antacid and enterosorbent drugs, when used in combination, reduce the absorption of glucosaminylmuramyl dipeptide.
With simultaneous use of the drug with glucocorticosteroids, a decrease in the severity of the therapeutic effect of glucosaminylmuramyl dipeptide is observed.
Overdose
Overdose of the drug Likopid has not been reported.Release form
Pills Lycopid Packed in blisters of 10 pieces, 1 or 2 blisters are included in a cardboard box.Storage conditions
Lycopid should be stored in dry rooms with a temperature not exceeding 25 degrees Celsius.Likopid is valid for 5 years after release.
The drug should be protected from exposure to direct sunlight.
Synonyms
GMDP.Compound
1 tablet of the drug Lycopid 1 contains:Glucosaminylmuramyl dipeptide (GMDP) - 1 mg;
1 tablet of the drug Likopid 10 contains:
Glucosaminylmuramyl dipeptide (GMDP) - 10 mg;
Additional ingredients including lactose and sucrose.
Main settings
| Name: | LYCOPIDE |
| ATX code: | L03AX - |
Trade name of the drug: Lykopid®
Chemical name:-L-alanyl-D-α-glutamide.
Dosage form: pills.
Compound:
Active substance: GMDP (glucosaminylmuramyl dipeptide) – 0.001 g and 0.01 g. Excipients: lactose, sucrose, potato starch, methylcellulose, calcium stearate.Description: round flat-cylindrical tablets of white color with a chamfer. Tablets with a dosage of 10 mg have a risk.
Pharmacotherapeutic group:
Immunostimulating agent.ATX code:
Pharmacological properties
The biological activity of the drug is due to the presence of specific binding centers (receptors) for GMDP, localized in the endoplasm of phagocytes and T-lymphocytes. The drug stimulates the functional (bactericidal, cytotoxic) activity of phagocytes (neutrophils, macrophages), enhances the proliferation of T- and B-lymphocytes, and increases the synthesis of specific antibodies. The pharmacological action is carried out by enhancing the production of interleukins (interleukin-1, interleukin-6, interleukin-12), tumor necrosis factor-alpha, interferon gamma, colony-stimulating factors. The drug increases the activity of natural killer cells.
Pharmacokinetics
The bioavailability of the drug when taken orally is 7-13%. The degree of binding to blood albumin is weak. Does not form active metabolites. The time to reach maximum concentration is one and a half hours after administration. The half-life is 4.29 hours. It is excreted unchanged from the body, mainly through the kidneys.
Indications for use
The drug is used in adults and children for the complex treatment of conditions accompanied by secondary immunodeficiencies:
In adults (tablets 1 mg and 10 mg)
- for chronic lung infections;
- for acute and chronic purulent-inflammatory diseases of the skin and soft tissues, including purulent-septic postoperative complications;
- for herpes infection (including ophthalmic herpes);
- for papillomavirus infection;
- for chronic viral hepatitis B and C;
- for psoriasis (including arthropathic form);
- with pulmonary tuberculosis;
In children (1 mg tablets only)
- for acute and chronic diseases of purulent-inflammatory skin and soft tissues;
- for chronic infection of the upper and lower respiratory tract, both in the acute stage and in remission;
- for herpetic infections of any location;
- for chronic viral hepatitis B and C.
Contraindications
Individual hypersensitivity to the drug, pregnancy and lactation, autoimmune thyroiditis in the acute phase, conditions in diseases accompanied by high fever or hyperthermia (>38°).
Directions for use and dosage in adults
Likopid is used sublingually or orally on an empty stomach, 30 minutes before meals.
To prevent postoperative complications, Likopid is prescribed 1 mg sublingually once a day for 10 days. For the treatment of purulent-septic processes of the skin and soft tissues of moderate severity, including postoperative ones, Likopid is prescribed in doses of 2 mg sublingually 2-3 times a day for 10 days. In the treatment of severe purulent-septic processes, Likopid is prescribed orally 10 mg once a day for 10 days.
For chronic lung infections, Lykopid is prescribed 1-2 mg sublingually once a day for 10 days.
For pulmonary tuberculosis, Lykopid is prescribed 10 mg 1 time per day under the tongue for 10 days.
For mild herpes infection, Likopid is prescribed 2 mg 1-2 times a day under the tongue for 6 days; for severe forms, 10 mg 1-2 times a day under the tongue for 6 days. For ophthalmoherpes, Lykopid is administered orally at a dose of 10 mg 2 times a day for 3 days. After a break of 3 days, the course of treatment is repeated.
For lesions of the cervix of the uterus by the human papillomavirus, Lykopid is prescribed in a dose of 10 mg orally 1 time per day for 10 days.
For psoriasis, Lykopid is prescribed in a dose of 10-20 mg orally 1-2 times a day for 10 days and then 10-20 mg every other day for the next 10 days. For severe forms and extensive damage (including arthropathic form), 10 mg 2 times a day for 20 days.
Method of administration and dosage in children
In newborns with a protracted course of infectious diseases (pneumonia, bronchitis, enterocolitis, sepsis, postoperative complications, etc.), Lykopid is used in a dose of 0.5 mg orally 2 times a day for 7-10 days.
In children aged 1-16 years, Likopid is used only in the form of 1 mg tablets.
In the treatment of chronic respiratory tract infections and purulent skin infections in children, Lykopid is used in a dose of 1 mg orally 1 time per day for 10 days.
When treating herpetic infections, regardless of location in children, Likopid is prescribed at a dose of 1 mg orally 3 times a day orally for 10 days.
For the treatment of chronic viral hepatitis B and C in children, Likopid is prescribed in a dose of 1 mg orally 3 times a day for 20 days.
Side effects
At the beginning of treatment, a short-term increase in body temperature (not higher than 37.9 ° C) may be observed, which is not an indication for discontinuation of the drug. No other side effects were identified during treatment with Likopid.
Overdose
There are no known cases of drug overdose.
Interaction with other drugs
The drug increases the effect of antibiotics from the group of semisynthetic penicillins, fluoroquinolones, cephalosporins, polyene derivatives, and there is synergism with antiviral and antifungal drugs. Antacids and sorbents significantly reduce the bioavailability of the drug. Glucocorticosteroids reduce the biological effect of Lykopid. It is not advisable to co-prescribe Licopid with sulfonamide drugs and tetracyclines.
special instructions
Does not affect the ability to drive a car or operate complex machinery.
Release form
Tablets of 1 mg and 10 mg.
10 tablets in a blister pack.
1 or 2 blister packs per pack, along with instructions for use.
Storage conditions
List B. In a dry place, protected from light, out of reach of children, at a temperature not exceeding 25°C.
Best before date
5 years.
Conditions for dispensing from pharmacies
On prescription.
Manufacturer
JSC "Peptek", Russia.
117997, Moscow, st. Miklouho-Maklaya, house 16/10.
The number of outbreaks of seasonal and cold diseases is steadily growing every year. Such illnesses become especially dangerous for children with weakened immune systems. To avoid frequent colds and viral diseases, experts recommend taking medications that help strengthen the body's protective functions. The most popular medication in this area is a drug called Lykopid.
The product showed a positive effect not only as a preventive measure for various acute respiratory infections and acute respiratory viral infections, but also for reducing the relapses of many chronic diseases.
The effect of the drug on the human body
According to the instructions, the beneficial effect of Lykopid is due to the stimulation of the phagocytic activity of leukocytes, macrophages and monocytes. This means that the above components destroy harmful cells that have entered the body. In addition, a complex of special additives activates the body’s own cells to fight viruses, which significantly strengthens the immune system.
The drug does not cause any side effects, and its use does not harm even very young children.
The medicine contains peptides synthesized from living bacteria - GMDP, which are an analogue of the cells of the body's own immune system, and have a similar operating principle. Thus, Lykopid works as a trigger that activates all protective functions in the human body. In addition to the fact that the drug prevents the formation and development of inflammatory processes, it helps to destroy harmful fungi, bacteria and viruses.
The medicine also contains protein-peptide molecules - cytokines, which perform several useful functions in the body:
- prolong the viability of immune cells;
- promote the active reproduction of antibodies in the body;
- create new white blood cells that help eliminate harmful bacteria that enter the body from the outside;
- improve the functioning of the immune, nervous and endocrine systems.
Likopid: reviews from immunologists
Due to the fact that this medicine activates all possible forms of protection: the body’s humoral and cellular immunity, as well as phagocytosis, the attitude of specialists towards the drug is very positive. In addition to strengthening the body's protective functions, the product is an excellent immunomodulator. It is prescribed for any form of immune deficiency in both adults and children.
Indications for use
- chronic and acute diseases of the respiratory system;
- viral hepatitis C and B;
- human papillomavirus infections;
- purulent viral inflammation of soft and mucous tissues;
- various forms and localizations of psoriasis and herpes.
Also, the instructions for use of Lykopid indicate a number of diseases in which the use of the drug will help to significantly reduce the severity of symptoms and alleviate the overall course of the disease. Such diseases include:
- chronic form of rhinitis, laryngotracheitis, pharyngitis, laryngitis;
- tuberculosis;
- ophthalmic, simple and genital herpes;
- arthropathic psoriasis.
The drug is also prescribed in case of frequent colds and herpes in children or adults. For bronchitis, pneumonia, long-term non-healing wounds, and also as a prevention of complications after surgery, Lykopid also shows a very positive effect.
Likopid for children - features of administration
Instructions for use of Licopid allow the drug to be taken by children over the age of one year. Despite this, many pediatricians prescribe the drug even to infants and newborns. The reason for this is that the medication does not contain harmful chemical compounds that can harm the baby’s health. And GMDP peptides, in small quantities, are even found in breast milk.
Despite the minimum side effects and the safety of the medication for very young children, the drug should only be given to children over one year old. Otherwise, the appointment should be carried out only after appointment and under the close supervision of a specialist.
Many parents are wondering what is better to give to children with a weakened immune system to improve health, Lykopid or its more common interferon-based analogues?
Clinical trials have shown the high effectiveness and absolute safety of the drug Likopid for children of preschool and primary school age. Therefore, for the drug Likopid, reviews from immunologists are almost unambiguous: this is the most suitable drug for strengthening the child’s immune system.
Many parents are also well aware of the problem of increased frequency of colds when visiting preschool institutions.
This happens due to the fact that the child’s still fragile immune system cannot fight back the numerous bacteria and viruses that it encounters when visiting kindergarten. The drug Likopid will help strengthen the baby’s immunity and resist many childhood diseases.
Contraindications for use
Likopid should not be taken in case of acute intolerance to one of the components included in the medication or GMDP. It would also be inadvisable to prescribe Licopid for diseases accompanied by elevated (above 38°C) body temperature, chills, fever and excessive sweating. In case of exacerbation of autoimmune diseases, such as thyroiditis, use is possible only after consultation with a specialist. During pregnancy and breastfeeding, the drug should be taken only after a doctor's prescription and under his strict supervision.
Contraindications for taking Lykopid also include the presence of ailments such as lactose deficiency and galactosemia.
Likopid in combination with other drugs
In combination with most medications, Likopid does not change its effect or their effects, so they are often prescribed in combination. A number of studies have shown that some antiviral and antifungal agents, as well as antibiotics, in combination with Lykopid show greater effectiveness in treatment.
But combination with sorbents and antacid drugs can reduce the absorption and effect of Lykopid. Therefore, they should be taken at different times.
How to take Lykopid
Release form: white round tablets in a dosage of 1 or 10 mg of the drug. Adults are recommended to take the drug at a dosage of 10 mg sublingually. Children's Lykopid (1 mg) can be dissolved in a small amount of water or given whole if the child can take it in this form.
The average duration of the treatment course is up to 10 days. The course can be repeated in the future. How much the drug needs to be taken and in what dosage is determined by the specialist strictly individually.
For better absorption and effectiveness, the medicine is taken on a completely empty stomach or 2 hours after eating.
Taking the drug for various ailments:
- for inflammatory processes and skin suppuration - a daily dose of the drug is 2-3 mg. Severe forms of the disease require increasing the dose to 10 mg;
- papillomavirus - up to 10 mg per day;
- strengthening the immune system after surgery - 2 mg per day;
- when treating psoriasis, Lykopid should be taken 10-20 mg per day for 7-10 days. In the future, the course must be repeated at 10-20 mg every two days. In especially advanced cases, the course of therapy can last up to 20 days;
- simple forms of herpes are treated by taking 2 mg of medication 1-2 times a day. More severe forms require increasing the dosage to 10-20 mg per day. The course duration is usually one week;
- if you have ophthalmoherpes, the medicine must be taken 20 mg per day for at least three days in a row. After a short break of 2-3 days, the course should be repeated;
- for acute and chronic diseases of the respiratory system - the medicine is taken once a day, 2 mg;
- tuberculosis - 10 mg once a day.
Features of taking Likopid in children
For pneumonia, laryngitis, bronchitis and rhinopharyngitis, the medicine is taken in a dosage of 1 mg 2 times a day. For hepatitis C and B, as well as herpes or inflammatory skin diseases - 1 mg up to 3 times a day.
Dosages shown are for guidance only. The exact duration and frequency of taking the drug is determined by the doctor, taking into account the general state of health and the form of the disease.
Possible side effects
In some cases, after taking the drug, body temperature may rise to 37.5 °C. This effect is normal and does not require taking antipyretics. Body temperature usually drops on its own, within several hours after taking the medicine, and does not affect the general well-being of both the adult and the child.
If your body temperature rises above 38.0°C, you should take an antipyretic drug and consult your doctor about further use of Lykopid. This side effect is extremely rare (approximately 0.01% of people) and most often does not require discontinuation of Lykopid.
Sometimes an allergic reaction may occur after taking the drug. Typically, allergy symptoms are noted to sucrose, which is part of the drug.
In rare cases, pain in the joints or muscles appears after taking the medication. Such indicators are not critical and do not require discontinuation of the immunomodulator. Only if pain increases or persists for a long time, you should stop taking the drug and consult a doctor.
A little about analogues
Today, there are no drugs on the domestic market that can compete with Likopid in their composition and amount of active substance. There are a number of drugs that have similar therapeutic effects and similar immunomodulatory effects. For example, in its ability to strengthen the immune system, Likpid is often compared with echinacea, but in its medicinal qualities it is significantly inferior.
Lykopid has a number of therapeutic effects that have a beneficial effect on human health, with virtually no side effects. The positive qualities of Lykopida are also proven by the fact that in 1996, he was awarded the Russian Government Prize in the field of development of technology and science.
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I have always been skeptical about immunomodulators. But when my frequently ill child was prescribed Lykopid 1 mg, I decided to try it. I was amazed by the effect. When he was 4 years old, he was sick almost every month with colds, tonsillitis, and rhinitis. We didn’t get out of illness. And after Lykopid we almost never get sick, and now these endless snot are over!
A good immunomodulator Lykopid. The children were sick non-stop. The pediatrician prescribed Likopid 1 mg. We drank it for 1 month. We haven’t been sick for many months now; we didn’t even get sick in the spring. In the fall we will carry out preventive maintenance for 10 days. The doctor recommended it.
My five-year-old child has been sick for about two years now. I suffered from sore throats very often. And so, ARVI, acute respiratory infections almost every month. During the consultation, the doctor suggested taking the immunomodulator Lykopid in a dosage of 1 mg. Initially, the course is 1 month. Tolerated it well, without adding an increase in temperature (listed in the instructions as a side effect). Then, to consolidate the result, she prescribed drinking for another 10 days. These are sweetish lozenges.
After this treatment of our weak immunity, we almost stopped getting sick. Even somehow fantastic, because... We were sick most of the time and went to the garden during breaks. They forgot about sore throats. It is rare to have a slight runny nose that goes away quickly. We are so excited about the restoration of our immunity!
After spending time with my child in an infectious disease hospital with double pneumonia last year, I decided that I’d stop joking and need to do something about the immune system. After discharge, the attending physician prescribed us a regimen to strengthen the immune system: Lykopid 1 mg for 10 days and vitamins to boost immunity in courses every six months. We drank Vitamishki. They are tasty. Lykopid, by the way, turned out to be surprisingly tasty too. My immunity really improved after this. Now we will take another course before the New Year.
But I liked that you only need to take pills for 10 days and that’s enough to strengthen your immune system. My son drank that much and stopped getting sick often. But I don’t believe in all the drops or pills that you need to take for months, because I tried it and it didn’t give any effect. But the doctor said we still need to wait. So how long can you wait if it’s not there and you want your child to stop constantly catching colds. Now I trust Likopid, we were prescribed a dosage of 1 mg, we drank according to the regimen prescribed by the doctor. There is nothing complicated, but it helps well.
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Tablets - 1 tablet. glucosaminylmuramyl dipeptide (GMDP) - 1 mg - 10 mg excipients: lactose; sucrose; potato starch; methylcellulose; calcium stearate in blister packs 10 pcs.; in a cardboard pack 1 or 2 packages.
Description of the dosage form
Round flat-cylindrical tablets of white color with a chamfer. Tablets with a dosage of 10 mg have a risk.
Pharmacokinetics
The bioavailability of the drug when taken orally is 7–13%. The degree of binding to blood albumin is weak. Does not form active metabolites. Tmax - 1.5 hours, T1/2 - 4.29 hours. Excreted from the body unchanged, mainly through the kidneys.
Pharmacodynamics
The biological activity of the drug is due to the presence of specific receptors (NOD-2) for glucosaminylmuramyl dipeptide (GMDP), localized in the endoplasm of phagocytes and T-lymphocytes. The drug stimulates the functional (bactericidal, cytotoxic) activity of phagocytes (neutrophils, macrophages), enhances the proliferation of T- and B-lymphocytes, and increases the synthesis of specific antibodies. The pharmacological action is carried out by enhancing the production of interleukins (IL-1, IL-6, IL-12), tumor necrosis factor-alpha, interferon gamma, and colony-stimulating factors. The drug increases the activity of natural killer cells.
Instructions
INSTRUCTIONS for use APPROVED by the Federal Code of the Ministry of Health of the Russian Federation, December 24, 1998, pr. No. 13. Description. White round tablets without coating. Pharmacological properties. The drug has immunomodulatory properties. In case of secondary immunodeficiencies in doses of 1-10 mg, it increases the activity of phagocytes (macrophages and neutrophils), T- and B-lymphocytes. At the same time, the bactericidal and cytotoxic activity of phagocytes increases, the synthesis of specific antibodies and cytokines (interleukins, tumor necrosis factor, interferons and colony-stimulating factors) is stimulated. The use of Licopid in complex therapy can significantly increase the effectiveness of antibacterial, antifungal and antiviral therapy, reduce the duration of treatment and significantly reduce the dose of chemotherapeutic agents. In autoimmune diseases, in doses above 20 mg, Licopid inhibits the biosynthesis of anti-inflammatory cytokines. Indications for use. Likopid is used in adults and children in the complex treatment of secondary immunodeficiencies, manifested in the form of chronic, sluggish, recurrent infectious and inflammatory processes of any localization. Likopid (1 and 10 mg tablets) is indicated as part of complex therapy in adults: - for chronic infections of the upper and lower respiratory tract for the treatment of exacerbations and prevention of relapses; - for acute and chronic purulent-inflammatory diseases of the skin and soft tissues, incl. for the treatment and prevention of purulent-septic postoperative complications; - for tuberculosis; - with ophthalmoherpes; - with lesions of the cervix by the human papillomavirus; - for all forms of psoriasis. Likopid (1 mg tablets) is indicated as part of complex therapy in children: - for the treatment of acute and chronic purulent-inflammatory diseases of the skin and soft tissues; - for herpetic infections of any localization; - for chronic viral hepatitis B and C. Method of administration and dosage. In adults. Likopid is used 30 minutes before meals orally (10 mg tablets) or sublingually (1 mg tablets). For infections of the upper and lower respiratory tract in the acute stage, Lykopid is prescribed 1-2 mg under the tongue 1 time per day for 10 days. To prevent exacerbations of chronic respiratory tract infections with a protracted, often recurrent course, Lykopid is prescribed 5-10 mg once a day for 10 days. To prevent postoperative complications, Likopid is prescribed 1-2 mg sublingually once a day for 5-10 days. For the treatment of purulent-septic processes of the skin and soft tissues, incl. postoperative, moderate severity Likopid is prescribed in a dose of 2 mg sublingually 2-3 times a day for 10 days. For severe purulent-septic processes, Likopid is prescribed orally 10 mg once a day for 10 days. For pulmonary tuberculosis, Lykopid is prescribed 10 mg 1 time per day orally for 10 days. For ophthalmoherpes, Lykopid is administered orally at a dose of 10 mg 2 times a day for 3 days. After a break of 3 days, the course of treatment is repeated. For lesions of the cervix of the uterus by the human papillomavirus, Lykopid is prescribed in a dose of 10 mg orally 1 time per day for 10 days. For the treatment of psoriasis, Lykopid is prescribed: for moderate prevalence of rashes, orally at a dose of 10 mg 1-2 times a day for 10 days and then for the next 10 days, 10-20 mg every other day; for a large affected area - 10 mg orally 2 times a day for 20 days. In children. In children aged 1-16 years, Likopid is used only in the form of 1 mg tablets. In the treatment of chronic respiratory tract infections and purulent skin infections in children aged 1-6 years, Lykopid is used orally in a dose of 1 mg once a day for 10 days. When treating herpetic infections of all localizations in children aged 1-16 years, Lykopid is prescribed orally at a dose of 1 mg 3 times a day for 10 days. For the treatment of chronic viral hepatitis B and C in children aged 1-16 years, Likopid is prescribed orally in a dose of 1 mg 3 times a day for 20 days. For protracted infectious diseases (pneumonia, bronchitis, enterocolitis, sepsis, postoperative complications, etc.) in newborns, Lykopid is administered orally at a dose of 0.5 mg 2 times a day for 7-10 days. Side effects. In some cases, a moderate increase in temperature is observed (up to 37.9 °C). Contraindications. Pregnancy, individual intolerance to the drug. Release form. Tablets of 1 and 10 mg, 10 pcs in a blister pack, 1 pack in a cardboard box. Storage conditions. In a dry, cool place, protected from light. List B. Conditions for dispensing from pharmacies. By doctor's prescription. Manufacturer. CJSC "Peptek"
Indications for use Lykopid
Complex therapy of secondary immunodeficiencies, manifested in the form of chronic, sluggish and recurrent infectious and inflammatory processes of any localization, namely: Adults: chronic infections of the upper and lower respiratory tract; acute and chronic purulent-inflammatory diseases of the skin and soft tissues ; tuberculosis; herpetic infections (including ophthalmic herpes); papillomatous viral infections (including the arthropathic form); psoriasis. Children: acute and chronic purulent-inflammatory diseases of the skin and soft tissues (treatment); in newborns - with prolonged the course of infectious diseases (pneumonia, bronchitis, enterocolitis, sepsis, postoperative complications, etc.); chronic infections of the upper and lower respiratory tract; herpetic infections; chronic viral hepatitis B and C.
Contraindications to the use of Lykopid
individual intolerance to the drug, pregnancy and lactation, autoimmune thyroiditis in the acute phase, high fever or hyperthermia (>38 C).
Likopid Use during pregnancy and children
Use during pregnancy is contraindicated; breastfeeding should be stopped during treatment. According to indications, it is used in children.
Likopid Side effects
short-term increase in body temperature (not higher than 37.9 °C)
Drug interactions
The drug increases the effectiveness of semisynthetic penicillins, fluoroquinolones, cephalosporins, and polyene derivatives. There is synergism with antiviral and antifungal drugs. Antacids and sorbents significantly reduce the bioavailability of the drug. GCS reduce the biological effect of Lykopid®. It is not advisable to co-prescribe Licopid® with sulfonamide drugs and tetracyclines.
Dosage Lykopid
Adults: table. 1 mg sublingually and tab. 10 mg orally, 30 minutes before meals. Children 1–16 years old: only in the form of tablets of 1 mg, orally. Chronic respiratory tract infections: in the acute stage - 1–2 mg sublingually 1 time per day for 10 days, in remission - 5–10 mg orally 1 time per day day for 10 days. Prevention of postoperative complications: 1–2 mg sublingually 1 time per day for 5–10 days purulent-septic processes of the skin and soft tissues of moderate severity, incl. postoperative: 2 mg sublingually 2–3 times a day for 10 days; severe purulent-septic processes: 10 mg orally once a day for 10 days. Pulmonary tuberculosis: 10 mg orally once a day for 10 days. Ophthalmoherpes: 10 mg orally 2 times a day for 3 days, after a break of 3 days the course is repeated. Damage to the cervix by human papillomavirus: 10 mg orally once a day for 10 days. Psoriasis: for moderate prevalence of rashes - 10 mg orally 1-2 times a day for 10 days, then 10-20 mg every other day for 10 days; for a large affected area - 10 mg orally 2 times a day for 20 days. Prevention of ARVI in frequently ill children 1.5–6 years old - 1 mg 1 time a day for 10 days; 6–12 years old - 1 mg 2 times a day for 10 days. With a protracted course of the infectious process (pneumonia, bronchitis, enterocolitis, sepsis, postoperative complications, etc.) in newborns: 0.5 mg 2 once a day for 7–10 days. Chronic respiratory tract infections and purulent skin infections: 1 mg 1 time per day for 10 days. Herpetic infections, regardless of location: 1 mg 3 times a day for 10 days. Chronic viral hepatitis B and C: 1 mg 3 times a day for 20 days
Lykopid is a modern immunomodulator that contains a synthetic analogue of natural peptidoglycan and is a biologically active fragment of the structure of bacterial cell walls.
The drug is suitable for the treatment of recurring and long-term diseases of the respiratory tract of a viral, bacterial and fungal nature. In addition, it is often recommended for preventive measures during the autumn-winter season.
According to medical statistics, Likopid is a safe remedy.
Reviews from people who have taken this drug are mostly positive. However, the pronounced effect and expected result after taking the drug are not clear for everyone.
Due to its advantages, the drug Likopid has become widespread among doctors and consumers:
- well tolerated by patients;
- increases the effectiveness of antiviral and antibacterial agents;
- convenient form of administration - tablets;
- suitable as preventive measures;
- the composition does not contain bacterial impurities, which ensures the absence of side effects.
Composition and release form
Lykopid is produced in the form of round white tablets containing the main element 1 mg or 10 mg. The pack may contain one or two blisters of 10 tablets each.
The main component of the drug is GMPD (glucosaminylmuramyl dipeptide).
In addition, the drug contains the following auxiliary components:
- lactose;
- sucrose;
- potato starch;
- calcium stearate;
- methylcellulose.
Should be considered! The packaging of the medicine is 1 mg with a silver pattern, 10 mg - with a bronze pattern.
Important! Likopid 1 mg and 10 mg are different drugs! Likopid 1 mg can be purchased at a pharmacy without presenting a doctor's prescription; it is suitable for children. Likopid 10 mg can only be purchased with a doctor's prescription and can only be prescribed to adults.
pharmachologic effect
The action of the drug is aimed at the following functions:
- stimulation of functional (bactericidal, cytotoxic) activity of phagocytes;
- increased proliferation of T- and B-lymphocytes;
- increase in the synthesis of specific antibodies;
- increased intensity of natural killer cells.
The pharmacological action is carried out using the enhanced performance of key interleukins, tumor necrosis factors alpha, interferon gamma.
The maximum level of concentration of the drug components in the circulatory system is reached 2 hours after use. It is excreted within five hours, usually unchanged in the urine.
Indications and contraindications
Taking the medication is contraindicated in the following situations:
- during pregnancy and breastfeeding;
- if there is an individual intolerance to any of the components of the drug;
- in case of presence of autoimmune diseases;
- if there is an increase in body temperature of more than 38 degrees at the time of taking the medicine;
- with impaired metabolism.
Instructions for use for adults
The tablets should be placed under the tongue, half an hour before eating. In case of an accidental break in taking the drug, you can take the medicine within 12 hours. If you miss more than 12 hours, you only need to take the pill according to the schedule, without taking the missed one.
The therapeutic course of purulent inflammation of the skin requires taking Lykopid 2 pills 1 mg 2-3 times 10 days.
Infectious lung diseases involves taking 1 or 2 pieces of 1 mg per day for 10 days.
When diagnosed with pulmonary tuberculosis, the dose is prescribed as a 10 mg pill per day for 10 days.
For the treatment course of herpetic diseases, the dose is prescribed depending on the form of the disease: 2 pieces of 1 mg 1-2 times no longer than a week (mild form); 1 pill 10 mg per day for 3 days (severe form).
Instructions for use for children
Likopid 1 mg can be taken by children from 1 year of age. Sometimes, according to indications, a course is prescribed for newborns, but always under the strict supervision of a doctor. The treatment regimen is considered based on the specific disease, the nature of the disease and the individual characteristics of the body. The child can dissolve the tablet whole or give it crushed in boiled water.
In cases of protracted infectious diseases in a newborn child, Lykopid can be given 0.5 mg 2 times a week or for up to 10 days.
Infectious diseases of the respiratory system and purulent lesions of the skin require taking 1 mg in a course of no longer than 10 days.
For a therapeutic course of herpetic diseases, you need to take 1 mg 3 times a day for 10 days.
For diagnoses of hepatitis B or C, take 3 pieces of 1 mg for 20 days.
Side effects
The medicine was generally well tolerated by patients.
The following side effects may occur during use:
- raising body temperature to 37.9. At higher body temperatures, an antipyretic drug is required. In this case, there is no need to stop taking Likopid, since its effect does not decrease.
- manifestation of diarrhea.
- Since the drug contains sucrose, allergic rashes may occur.
No overdose from taking the drug has been identified.
Interaction with other drugs
Concomitant use with tetracyclines or sulfonamides is not recommended.
When taken in combination with penicillins and cephalosporins, the effect of antibiotics is enhanced.
Combined use with antifungal and antiviral drugs, Lykopid helps to increase their effect on the body. 
Taking Likopid does not affect the ability to drive vehicles or perform other activities that require concentrated attention.
In addition, taking Likopid helps reduce the dosage of medications and the duration of chemotherapy.
Price, analogues
You can buy Lykopid at pharmacies. The cost depends on the dosage and the number of blisters in the pack. The average price of the drug Likopid 10 mg is 1,700 rubles per pack of 10 pieces; 1 mg – 300 rubles for 10 tablets.
In modern times, there are enough immunomodulator drugs that are aimed at strengthening the immune system. Such are known as Bronchomunal, Viferon, Isoprinosine and others. However, Likopid is a drug with a wide spectrum of actions that has no domestic analogues.
The shelf life is 5 years; after the expiration date, the drug cannot be taken.
The medicine should be stored at a temperature no higher than 25 degrees, avoid exposure to moisture and sunlight. It is necessary to put it out of the reach of children.
