Neuromultivit tablets are indicated for use in children. Neuromultivitis

Being a complex drug, Neuromultivit includes three vitamins belonging to the vitamin group B. Namely, pyridoxine, thiamine, cyanocobalamin.

Vitamin B1 or thiamine hydrochloride is necessary for the proper functioning of metabolic processes - carbohydrate, protein and lipid. It is also directly involved in the process of impulse transmission in nerve endings.

Or pyridoxine hydrochloride is a substance that is necessary for the proper functioning of the nervous system, both central and peripheral. With its participation, a number of substances are synthesized in the human body, without which the normal course of many nervous processes would be impossible. For example, norepinephrine, adrenaline, dopamine.

Or cyanocobalamin is also necessary for the normal functioning of the nervous system. In addition, this substance is necessary for the maturation of red blood cells and for the implementation of many metabolic processes.

Each Neuromultivit tablet contains 100 mg of thiamine hydrochloride, 200 mg of pyridoxine hydrochloride, 200 mcg of cyanocobalamin. The tablet has a film shell of almost white color.

When is the drug indicated?

As a rule, Neuromultivit is prescribed in complex therapy of many neurological diseases, that is, in combination with other drugs. Thus, the use of this drug is indicated for people suffering from polyneuropathy, which can have different origins. Including for the treatment of diabetic and alcoholic polyneuropathy.

Other indications for use of Neuromultivit:

• lumbago;
• neuralgia of various localizations;
• intercostal neuralgia;
• neuritis;
• sciatica;
• plexitis;
• facial nerve paresis;
• radicular syndrome, which can be caused by a degenerative process in the spine;
• inflammation of the trigeminal nerve.

Are there any contraindications?

Like any drug, there are contraindications to the use of Neuromultivit, but there are very few of them. The drug should not be prescribed to people who are allergic to at least one component of its composition.

In pediatrics, the use of this drug is permitted only for therapy for children over 12 years of age.

It is not advisable to prescribe Neuromultivit to pregnant women at any stage, as well as to breastfeeding mothers.

How to use the drug correctly?

The main thing is that The film-coated tablet must be taken whole. It should not be crushed or chewed, otherwise the effectiveness of this drug will be significantly reduced. Neuromultivit should be taken immediately after meals. You need to drink it with water, you can also use tea for this.

The dosage of the drug is selected by the doctor depending on the severity of the disease, as well as the presence of concomitant pathology. Prescribe it one tablet one to three times a day. The duration of the course is determined by the doctor, however its use for more than 4 weeks is undesirable.

How much does a vitamin complex cost?

Of course, depending on the city or pharmacy where you purchase the drug, its price may vary. On average across the country, a package of Neuromultivit, which contains 20 tablets, costs from 171 to 302 rubles. A package of 60 tablets costs 503 - 612 rubles.

Experts' opinion

Antipova T. M, pharmacist. Today, the drug Neuromultivit is one of the most accessible B-vitamin products. Everyone knows what vitamin deficiencies in group B mean for a person. These are irritability, nervousness, brittle nails. And the complex vitamin preparation Neuromultivit is a good way to strengthen the nervous system.

What do patients say?

Anna, 35 years old. She slept poorly and was irritable. I was very exhausted at work. Then a friend recommended Neuromultivit and I decided to take it. Started taking the drug with caution. At first I took one tablet a day, and after about 10 days I noticed that I began to fall asleep quickly and my sleep became deeper. I continue taking the medicine, I wonder what will happen next.

Alexander Petrovich, 58 years old. My review is rather positive. I read the neuromultivit readings and was surprised by the impressive list. I myself have neuralgia, which I have been suffering from for a long time. I tried everything, but it didn’t help. So I decided to take Neuromultivit, and after one month I noticed that the pain was no longer so strong. I think I will continue taking the pills.

Neuromultivitis in ampoules

Each ampoule of the drug contains a solution in a volume of 2 ml. The solution contains the same active substances as the tablet form. Namely, pyridoxine hydrochloride, thiamine hydrochloride, cyanocobalamin. There are also excipients - water for injection, diethanolamine. Cyanocobalamin in the amount of 1 mg, pyridoxine hydrochloride 100 mg, thiamine hydrochloride 100 mg.

When is the drug used?

• neuralgia of different localization;
• neuritis;
• radiculoneuritis arising as a result of degenerative diseases of the spine (vertebral syndrome, cervical syndrome and others);
• intercostal neuralgia;
• inflammation of the trigeminal nerve;
• sciatica.

Contraindications to the use of the liquid form of Neuromultivit similar to those described above. But, nevertheless, they have some differences:

• allergy to the main or auxiliary components of the drug;
• erythrocytosis and erythremia;
• hypervitaminosis;
• children under 12 years of age;
• pregnancy;
• lactation.

Correct Application

Administration of the drug is allowed only into the muscle. Only in the gluteal muscle according to the rules. For mild cases of the disease, the neurologist prescribes one injection two or three times a week. In severe or acute conditions, one ampoule is prescribed daily until the syndrome is relieved.

The average price of Neuromultivit in ampoules is about 220 rubles.

Experts' opinion

Uchelkina L. A., pharmacist. I can recommend the combined drug Neuromultivit, which contains three vitamins from group B. It should be used as part of a complex treatment of various neurological diseases. It has a beneficial effect on nerve endings and the entire system.

Vitamins of group B are included in the complex therapy of osteochondrosis. Taking B vitamins in the body increases the energy potential and normalizes the functioning of the central nervous system. One of the effective combined remedies of this group is Neuromultivit.

pharmachologic effect

Neuromultivit is a medicinal product from the group of vitamins and vitamin-like products, which is produced by the Austrian-German pharmaceutical concern Lannacher Heilmittel GmbH.

Thanks to its special composition, the vitamin stimulates metabolic processes in the nervous system, promotes regeneration at the cellular level in the central and peripheral nervous system.

The vitamin product Neuromultivit has a moderate analgesic effect. The combined drug stimulates the processes of central nervous activity and improves sleep.

Composition and release form

The drug Neuromultivit contains a complex of B vitamins and neurotropic active substances:

1. Vitamin B1 participates in enzymatic reactions of the body, regulates carbohydrate, lipid and protein metabolism.
2. Vitamin B6 supports the normal functioning of higher and peripheral nervous activity, takes part in the synthesis of adrenal hormones,
3. Vitamin B12 supports the functionality of hematopoietic organs and prevents fatty degeneration of organs.

Photo gallery:

One dosage form of Neuromultivit, a biconvex tablet, contains the main active ingredients of vitamins:

• thiamine 0.1 g;
• pyridoxine 0.2 g;
• cyanocobalamin 0.2 mg.

As excipients, the vitamin preparation Neuromultivit is supplemented with microcrystalline cellulose, magnesium stearate, titanium dioxide, and talc.

Indications for use

Neuromultivit does not apply to drugs intended for the treatment and prevention of hypovitaminosis.

This medicinal vitamin product is prescribed only in the complex treatment of neurological diseases:

1. neuralgia;
2. neuritis;
3. radicular syndrome;
4. polyneuropathy;
5. discogenic radiculopathies;
6. polyneuropathy;
7. cerebroasthenia;
8. inflammation of the meninges;
9. metabolic encephalopathy;
10. osteochondrosis with manifestations of neurological symptoms.

Therapy for osteochondrosis is aimed not only at relieving pain. Spasm, inflammation, restoration of spinal structures and damaged nervous tissue are also the main tasks that complex treatment of osteochondrosis should solve.

In order for regeneration processes to be launched, the vitamin preparation Neuromultivit must be included in the treatment of acute and chronic osteochondrosis.

How Neuromultivit helps with acute and chronic osteochondrosis:

• strengthens the immune system;
• regenerates cartilage and nerve tissue;
• helps improve the conductivity of nerve endings, restores their sensitivity;
• gives a moderate analgesic effect;
• prevents the degenerative process from developing further.

B vitamins do not accumulate. Therefore, in order for the recovery and recovery processes for osteochondrosis to be successful, the use of Neuromultivit and injectable vitamin preparations are included in the mandatory drug therapy program.

Contraindications and side effects

The Neuromultivit vitamin complex is contraindicated in patients with hypersensitivity or allergic reactions to B vitamins.

You can read more about vitamins for osteochondrosis.

The vitamin remedy Neuromultivit is also not allowed to be used in the treatment of pregnant women, lactating women, children and adolescents under 18 years of age.

Side effects during treatment with Neuromultivitis are extremely rare. In isolated cases, dyspepsia, rapid heartbeat, rashes and urticaria are possible.

After discontinuation of the vitamin preparation, adverse reactions disappear on their own and do not require symptomatic therapy.

Drug interactions

The vitamin remedy Neuromultivit is not prescribed if the patient is taking antiparkinsonian medications.

During treatment with Neuromultivit, multivitamin complexes and injectable forms of vitamins belonging to group B are contraindicated.

Instructions for use and dosage

Self-administration of Neutromultivit should be completely avoided by patients. The vitamin preparation is taken only as prescribed by a doctor.

Neuromultivitis is usually prescribed 1-3 tablets per day. The tablet is taken after meals.

The course of treatment is determined by the attending physician. Average course: one month.

Drug price

Analogues substitutes

Analogues similar in composition and pharmacological action include:

1. . Complex vitamin preparation in injection solutions and tablets. Manufacturer: Worwag Pharma GmbH & Co. KG" (Germany).
2. Pentovit. Tablet preparation. In addition to B vitamins, it additionally contains vitamin PP. Manufacturer: CJSC "ALTAIVITAMINS" (Russia).
3. Combilipen. Complex vitamin product in injection solutions. In addition to the main active ingredients of B vitamins, the vitamin product contains lidocaine with a local anesthetic effect. Manufacturer: Pharmstandard-UfaVITA OJSC (Russia).
4. Neurobion. The product is available in tablets and injection solutions. Manufacturer: Merck KGaA (Germany).
5. Neurobex (Forte, Neo). The product is available in tablets. In addition to vit. B1, B6, B12, there is vit. B2, B5, B9, RR, S. Manufacturer: “Balkanpharma Dupnitsa AD” (Bulgaria).
6. Vitaxon. The drug is available only in injection solutions. Manufacturer: Farmak JSC (Ukraine).
7. Nerviplex. The product is available only in injection solutions. Manufacturer: Jason Pharmaceuticals Ltd. (Bangladesh).

Photos of analogues:

Content

Nervous stress at work, overwork, and various nervous diseases can serve as the beginning of serious, destructive and even fatal processes in the body. To strengthen the nerves, medicine has developed the drug Neuromultivit, which successfully combines the three most important vitamins of group B. Indications for use of the drug are listed on the pages of the pharmaceutical instructions. Extensive practice of using Neuromultivit confirms its effectiveness.

Composition and release form

The drug Neuromultivit is available in the form of film-coated tablets. The composition is represented by active and auxiliary components, substances that make up the tablet shell.

Pharmacodynamics and pharmacokinetics

Instructions for use of Neuromultivit contain information about each component of the composition. More information about the pharmacodynamics and pharmacokinetics of water-soluble vitamins:

1. Thiamine hydrochloride or vitamin B1 during phosphorylation is converted into cocarboxylase, which serves as a coenzyme and takes part in many enzymatic reactions. The substance is involved in protein, carbohydrate and fat metabolism, the process of conducting nervous excitation in synapses, alpha-keto acids. Thiamin hydrochloride is absorbed in the upper intestine, metabolized in the liver, and excreted by the kidneys.
2. Pyridoxine or vitamin B6 is needed by the body for the normal functioning of all parts of the nervous system. Its phosphorylated form is a coenzyme and takes part in the metabolism of amino acids, including the processes of peramination and decarboxylation of glycosphingolipids. The substance is a coenzyme in enzymatic reactions within nerve tissue. It is involved in the synthesis of the neurotransmitters dopamine, adrenaline, norepinephrine, gamma-aminobutyric acid, and histamine. Pyridoxine is metabolized in the liver and excreted by the kidneys.
3. Vitamin B12 or cyanocobaolamine is involved in the process of normal hematopoiesis, maturation of red blood cells, and biochemical reactions to ensure the vital functions of the body. Without it, the transfer of methyl groups and the exchange of amino acids, lipids and carbohydrates are impossible. The vitamin affects the production of nucleic acids, the lipid composition of phospholipids, and cerebrosides. Coenzyme forms methylcobalamin and adenosylcobalamin take part in the replication and growth of cells and affect acidity. Delivery of cyanocobalamin to tissues occurs due to the protein transcobalamin. The substance is metabolized in the liver and excreted in the bile or kidneys.

Indications for use of Neuromultivit

The instructions highlight a list of diseases and pathological conditions of the nervous system for which Neuromultivit is prescribed. Direct indications for use:

• plexitis (cervical, lumbosacral, shoulder);
• sciatica (damage to the sciatic nerve);
• lumbago (lumbar lumbago, sciatica, lumboischialgia);
• diabetic polyneuropathy;
• alcoholic polyneuropathy, polyneuritis, paralysis;
• mononeuropathy;
• prosoplegia;
• radiculopathy (stimulation of the diseased area);
• psychosis;
• metabolic disorders;
• neuralgia and neuritis;
• trigeminal neuralgia;
• degenerative diseases of the spine with radicular syndrome;
• intercostal neuralgia.

Directions for use and dosage

The tablets are taken orally with water. It is not recommended to crush, crush or chew the tablet, as this may cause a change in the pharmacokinetic profile of Neuromultvit in the digestive tract. The maximum therapeutic effect is achieved when taken immediately after meals. The standard regimen involves prescribing from 1 to 3 tablets per day (depending on symptoms). The permissible age for therapy is from 12 years.

special instructions

The pharmacological features of Neuromultivit made it necessary to indicate a number of special instructions in the instructions. When using the drug you need to pay attention to the following points:

• high doses are allowed to be taken for no more than 4 weeks in a row, otherwise there is a risk of neurological symptoms;
• absorption of thiamine (vitamin B1) decreases when drinking black tea;
• under the influence of sulfites, the process of destruction of thiamine is accelerated;
• due to the presence of vitamin B6 in the drug, it is necessary to prescribe Neuromultivit with caution to patients with duodenal and gastric ulcers, with significant liver and kidney dysfunction;
• in patients with pernicious anemia or funicular myelosis, the use of vitamin B12 may lead to a loss of specificity of the clinical picture of the disease;
• if neoplasms are detected, therapy should be discontinued (exceptions include cases of megaloblastic anemia and B12 deficiency);
• The drug should not be used if you are diagnosed with angina pectoris or with acute or severe decompensation of heart failure.

Neuromultivitis during pregnancy

Neuromultivit vitamins, according to the instructions for use, are not recommended during pregnancy and breastfeeding (lactation). This is due to the fact that there is no reliable clinical data on the safety of using the drug in patients of these categories. It is possible that the drug will adversely affect the development of the fetus or newborn baby.

Neuromultivitis for children

According to the instructions, the use of Neuromultivit in children under 12 years of age is contraindicated. This limitation is due to the lack of information about the effectiveness and safety of using the drug in this group of patients. Pediatricians use the medicine earlier, but after the child reaches one year. If you start taking it before one year, there is a risk of overdose - the vitamin content in Neuromultivit is 10 times higher than the baby’s daily requirement.

Prescribing vitamins in pediatrics is necessary to activate metabolic processes occurring at the cellular level, restore functions and improve the condition of the nervous system. Vitamin B6 is important for the child’s psyche, it is an irreplaceable source of energy, participates in the metabolism of amino acids, the transmission of nerve impulses, and the synthesis of neurotransmitters. Vitamin B12 improves oxygen saturation of tissues and organs.

Neuromultivitis is indicated for inadequate or incorrect diet, neuralgia, increased physical and neuropsychic stress. Children can be given three tablets per day - one three times a day after meals, washed down with a small amount of water. For babies under one year of age, the drug is prescribed with caution, a quarter of a tablet twice a day. It is allowed to crush the dose and mix it with formula or breast milk. You should not take the drug for more than 4 weeks in a row and before bedtime, because insomnia may occur.

Drug interactions

The interaction of Neuromultivit with other medications is described in the instructions. Examples of combinations:

1. The drug reduces the antiparkinsonian effect of Levodopa when used simultaneously.
2. During treatment, you should not take other complex supplements based on B vitamins to avoid the development of hypervitaminosis.
3. 5-fluorouracil minimizes the activity of thiamine because it competitively inhibits its phosphorylation to cocarboxylase.
4. Antacids slow down the absorption of vitamin B1.
5. Long-term use of Neuromultivit with loop diuretics, Furosemide, and other agents to inhibit tubular reabsorption increases the elimination of thiamine and reduces its level.
6. When combining the drug with pyridoxine antagonists, antituberculosis drugs Isoniazid and Cycloserine, penicillamine, the vasodilator Hydralazine, and oral contraceptives, the need for vitamin B6 increases.

Compatibility of Neuromultivit and alcohol

According to the instructions, Neuromultivit and alcohol are incompatible, therefore, during therapy with the drug, the intake of any alcoholic or alcoholic beverages is prohibited. This limitation is due to the fact that the combination of vitamin B1 and ethanol leads to a decrease in the absorption of the former by almost a third. This reduces the effectiveness of the drug and may end unfavorably.

Side effects

Neuromultivitis is well tolerated, only isolated cases of administration result in side effects. The instructions include nausea, itching, skin hypersensitivity reactions, tachycardia, and urticaria. Allergies may occur. If unpleasant symptoms develop, you should stop taking the drug and consult your doctor.

Overdose

The likelihood of developing an overdose is small; this is possible if you take extremely high doses of B vitamins for a long time. After taking more than 2 g per day of vitamin B6, ataxia, sensitivity disorders, convulsions, hypochromic anemia, and seborrheic dermatitis develop. After exceeding the dose of cyanocobalamin, acne and eczematous skin changes may develop. According to the instructions, symptomatic treatment is prescribed. There is no antidote.

Contraindications

The instructions indicate contraindications for the use of Neuromultivit. These include:

• childhood;
• hypersensitivity to the components of the composition;
• allergies (for vitamin B1);
• exacerbation of peptic ulcer or duodenal ulcer (for pyridoxine);
• erythremia, Vaquez's disease, thrombus embolism of the blood vessels, erythrocytosis (for vitamin B12).

Terms of sale and storage

Neuromultivit is a prescription drug stored at temperatures up to 25 degrees for three years.

Analogs

You can replace the product with drugs based on B vitamins. These include:

• Angiovit - tablets with the same component composition with the addition of glucose;
• Multi-tabs B-complex – multivitamin tablets with B vitamins and others;
• Beviplex – lyophilized powder for injection solution based on a vitamin complex;
• Pentavit - tablets with the same composition, enhanced with nicotinamide and folic acid;
• Purified dry brewer's yeast - powder or capsules with B vitamins, amino acids;
• Medivitan is a solution of B vitamins to replenish their deficiency.

Milgamma or Neuromultivit – which is better?

Neuromultivit solution and tablets are often compared with the drug Milgamma. It contains the same active ingredients, but is additionally enhanced with lidocaine so that the injection is not so painful. Milgamma tablets do not contain lidocaine, so they can be considered a structural analogue of Neuromultivit. The doctor decides which one is better, but we must remember that Milgamma cannot be used in the treatment of children.

Neuromultivit price

The drug Neuromultivit is sold in pharmacy chains or online departments. Its cost depends on the form of release and pricing policy. In Moscow prices will be.

Active substances: One film-coated tablet contains:
Thiamine hydrochloride(vitamin B 1) – 100 mg,
Pyridoxine hydrochloride(vitamin B 6) – 200 mg,
Cyanocobalamin(vitamin B 12) – 0.2 mg.
Excipients: pregelatinized starch, sodium citrate, citric acid monohydrate, anhydrous colloidal silicon dioxide, microcrystalline cellulose, magnesium stearate, povidone, macrogol 6000, titanium dioxide (E171), talc, hypromellose, dispersible polyacrylate 30%.

Pharmacotherapeutic group

Vitamins. Vitamin B1 in combination with vitamin B6 and/or B12.
ATX code: A11DB

Pharmacological properties

Vitamin B 1 (thiamine hydrochloride) takes part in carbohydrate metabolism and affects the functional state of the nervous system.
Vitamin B 6 (pyridoxine hydrochloride) induces the metabolism of amino acids in nerve tissues and affects the biosynthesis of many known mediators such as dopamine, adrenaline and norepinephrine.
Vitamin B 12 (cyanocobalamin) affects, in particular, the metabolism of fatty acids in nerve tissues and is necessary for cell growth and replication.

Indications for use

Neurological disorders caused by a deficiency of vitamins B 1, B 6 and B 12, which cannot be eliminated by correcting nutrition.

Contraindications

Hypersensitivity to any of the components included in the drug. Due to the high content of active substances, the drug should not be taken by persons under 18 years of age.

Impact on the ability to drive vehicles or machinery

Neuromultivitis does not affect the ability to drive vehicles or operate machinery.

Use during pregnancy and lactation

Due to insufficient experience, it is not recommended to use Neuromultivit during pregnancy and breastfeeding.
Pregnancy
The recommended daily intake of vitamin B 1 during pregnancy and lactation is 1.7-1.8 mg, vitamin B 6 2.3-2.5 mg, vitamin B 12 3.5 mcg.
These doses can be exceeded during pregnancy only if the patient has a proven deficiency of vitamins B 1, B 6, B 12, since the safety of using doses higher than the daily recommended dose has not yet been proven.
There are insufficient animal studies on the effects on pregnancy, embryofetal and pre- and postnatal development of the offspring. The potential risk to humans is unknown.
Lactation
Vitamins B 1, B 6 and B 12 pass into breast milk. High concentrations (600 mg per day) of vitamin B6 may suppress milk production. There are no data on the extent of passage into milk in animals.

Interaction with other drugs and other types of interactions

Vitamin B6 may decrease the effectiveness of levodopa when used concomitantly. Thiamine is inactivated by 5-fluorouracil as a result of the latter's competitive inhibition of thiamine phosphorylation.
Long-term treatment with furosemide may increase renal excretion of thiamine. Isoniazid, cycloserine, D-penicillamine may reduce the effectiveness of vitamin B6 (pyridoxine).
Antacids, alcohol and tea reduce the absorption of thiamine.
Concomitant use of pyridoxine antagonists (eg, isoniazid, hydralazine, D-penicillamine or cycloserine) may reduce the effectiveness of vitamin B6.
Sulfite-containing drinks (such as wine) help break down thiamine.

Special instructions and precautions for use

Tell your doctor immediately if you experience any side effects or if you are pregnant.
Treatment with large doses of the drug for longer than 4 weeks is not recommended.
When used in the elderly and in persons with impaired liver and/or kidney function, dosage adjustment is usually not required.

Directions for use and doses

The usual dose is one tablet once a day. However, after preliminary consultation with a doctor, the dose can be increased to 1 tablet 3 times a day.
The tablets should be swallowed without chewing, after meals, with a small amount of liquid.
The course of treatment should not exceed 4 weeks, after which the attending physician must decide on further therapy.
If you miss a pill, take the next one at the usual time; do not double the dose to make up for the missed pill.

Overdose

Vitamin B 1
There are no known cases of overdose.
Thiamine has a wide therapeutic range. Very high intravenous doses (more than 10 g) have a ganglion-blocking effect and curare-like suppression of neuronal impulse transmission.
Vitamin B 6
Taking more than 2 g (corresponding to 10 Neuromultivit tablets) daily can cause dysfunction of the nervous system, such as movement disorders, sensory disturbances (tingling, numbness), convulsions and changes in the EEG. In rare cases, anemia and rash.
The toxic potential of vitamin B 6 is considered very low. However, long-term use (more than 6-12 months) of daily doses of vitamin B 6 of 50 mg causes the development of peripheral sensory neuropathy, these symptoms gradually decrease after stopping the consumption of the vitamin.
When vitamin B6 is taken continuously for more than 2 months, in doses above 1 g per day, neurotoxic side effects may occur.
Vitamin B 12
After parenteral administration of high doses (in rare cases, after oral administration), allergic reactions, eczema and acne are observed.
Treatment for overdose:
Treatment should be supportive and symptomatic.

Side effect

Like all medicines, Neuromultivit can cause side effects, although not everyone gets them.
The following adverse reactions have been reported:
- rarely (less than one in 1000 patients): headache, dizziness, nausea.
- very rarely (less than one in 10,000 patients): hypersensitivity reactions, appearing mainly on the skin after taking vitamin B 1 or B 12, itching, urticaria.
- with unknown frequency (cannot be estimated based on available data): peripheral sensory polyneuropathy with prolonged use of more than 6 months, tachycardia, profuse sweating, chronic excessive consumption of high doses of vitamin B 6 can cause sensitivity disorders, photosensitivity when using high daily doses of the drug .
Reporting Adverse Reactions
If you experience any unwanted reactions, it is recommended to consult your doctor. This recommendation applies to any possible adverse reactions, including those not listed in the package insert. You can also report adverse reactions to the Adverse Drug Events Information Database, including reports of drug failure. By reporting adverse reactions, you can help provide more information about the safety of the drug.

Combined preparation of B vitamins.

Thiamine (vitamin B 1) in the human body, as a result of phosphorylation processes, is converted into cocarboxylase, which is a coenzyme of many enzymatic reactions. Thiamine plays an important role in carbohydrate, protein and fat metabolism. Actively participates in the processes of nerve excitation in synapses.

Pyridoxine (vitamin B 6) is necessary for the normal functioning of the central and peripheral nervous system. In its phosphorylated form, it is a coenzyme in the metabolism of amino acids (including decarboxylation, transamination). Acts as a coenzyme for the most important enzymes operating in nerve tissues. Participates in the biosynthesis of neurotransmitters such as dopamine, norepinephrine, adrenaline, histamine and GABA.

Cyanocobalamin (vitamin B 12) is necessary for normal hematopoiesis and maturation of red blood cells, and is also involved in a number of biochemical reactions that ensure the vital functions of the body (in the transfer of methyl groups, in the synthesis of nucleic acids, proteins, in the metabolism of amino acids, carbohydrates, lipids). It affects processes in the nervous system (RNA, DNA synthesis) and the lipid composition of cerebrosides and phospholipids. Coenzyme forms of cyanocobalamin - methylcobalamin and adenosylcobalamin - are necessary for cell replication and growth.

Pharmacokinetics

The components of the drug are water-soluble vitamins, which eliminates the possibility of their accumulation in the body.

Suction and distribution

Thiamine and pyridoxine are absorbed in the upper intestine, the extent of absorption depends on the dose.

The absorption of cyanocobalamin is largely determined by the presence of intrinsic factor in the stomach and upper intestine; further delivery of cyanocobalamin to the tissue is carried out by the transport protein transcobalamin II.

Metabolism

Thiamine, pyridoxine and cyanocobalamin are metabolized in the liver.

Removal

Thiamine and pyridoxine are excreted by the kidneys (about 8-10% unchanged). In case of overdose, the excretion of thiamine and pyridoxine through the intestines significantly increases.

Cyanocobalamin is excreted mainly with bile, the degree of excretion by the kidneys is variable - from 6 to 30%.

Release form

White or almost white, film-coated tablets, round, biconvex; on a cross section - from white to light pink, interspersed with light pink to dark pink.

Excipients: microcrystalline cellulose - 80 mg, magnesium stearate - 4.8 mg, povidone - 15 mg.

Shell composition: macrogol 6000 - 9 mg, titanium dioxide - 11.25 mg, talc - 30 mg, hypromellose - 7.5 mg, methyl methacrylate and ethyl acrylate copolymer (1:2) (dispersion 30%) - 2.25 mg.

20 pcs. - blisters (1) - cardboard packs.

Dosage

Prescribe 1 tablet orally. 1-3 times/day. The duration of the course is determined individually.

The tablets should be taken after meals, without chewing and with a small amount of liquid.

Overdose

Symptoms: clinical symptoms of an overdose of vitamins contained in Neuromultivit ® can only be expected after taking extremely high doses for a very long time.

Vitamin B 1 - no symptoms of overdose after oral administration were noted.

Vitamin B 6 - after taking more than 2 g/day, neuropathies with ataxia and sensory disturbances, convulsions with EEG changes and, in some cases, hypochromic anemia and seborrheic dermatitis have been described.

Vitamin B 12 - after parenteral administration (in rare cases, after oral administration), eczematous skin changes and acne were observed.

Treatment: symptomatic therapy.

Interaction

With the simultaneous use of the drug Neuromultivit ® and levodopa, a decrease in the antiparkinsonian effectiveness of levodopa is observed.

With the combined use of the drug Neuromultivit ® and ethanol, the absorption of thiamine, which is part of the drug, is sharply reduced (the level in the blood can decrease by 30%).

During treatment with Neuromultivit ® it is not recommended to take multivitamin complexes containing B vitamins.

Side effects

In isolated cases: nausea, tachycardia, skin reactions in the form of itching and urticaria.

The drug is well tolerated.

Indications

As part of complex therapy for the following neurological diseases:

• polyneuropathy of various etiologies (including diabetic, alcoholic);
• intercostal neuralgia;
• trigeminal neuralgia;
• radicular syndrome caused by degenerative changes in the spine;
• cervical syndrome;
• glenohumeral syndrome;
• lumbar syndrome;
• lumboischialgia.

Contraindications

• children's age (the effectiveness and safety of the drug have not been studied);
• hypersensitivity to the components of the drug.

Features of application

Use during pregnancy and breastfeeding

Use in children

Contraindicated in children.

special instructions

Cyanocobalamin may mask the symptoms of folic acid deficiency.

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