In advanced stages of hemorrhoids, bleeding often occurs. This process has an adverse effect on the body, because against the background of this, anemia and vitamin B deficiency develop. To prevent complications and compensate for the loss of microelements, doctors prescribe iron-based antianemic drugs.
Gyno-Tardiferon for hemorrhoids - composition and effect of the drug
The medication belongs to the category of combined drugs. It contains iron and folic acid. 1 tablet contains 256 g of ferrous sulfate and 350 mcg of folic acid. There are also auxiliary ingredients in the form of dibutyl phthalate, ascorbic acid, magnesium stearate, castor oil, talc, anhydrous mucoproteose. There is a shell on top. It contains beeswax and titanium dioxide. It is prescribed as a therapeutic and prophylactic agent for anemia and prolonged bleeding against the background of advanced hemorrhoids.
Release form
Gyno-Tardiferon is sold in tablets. The pills are distinguished by their biconvex shape, smooth surface and light shade. On the inner cut they are brown in color and have a white edge. Thanks to the special shell, a long and prolonged effect of the drug is ensured. 1 pack contains 30 tablets.
pharmachologic effect
The drug is considered a hematopoiesis stimulator. Belongs to the category of antianemic drugs.
Ferrous sulfate is responsible for the level of hemoglobin in the blood. This component is also found in myoglobin and enzymes. When taking tablets, you can quickly make up for its deficiency.
Folic acid is responsible for the formation of normoblasts and the maturation of megaloblasts. It helps in the synthesis of nucleic acids, amino acids, and pyrimidines.
Thanks to the neutral shell, absorption of the active components occurs gradually in the thin section of the intestinal canal.
Pharmacodynamics and pharmacokinetics
Absorption of active substances occurs in the initial part of the small intestine. Iron salts interact with plasma proteins by 90%. It is stored in the form of hemosiderin and ferritin. Some of it ends up in muscle structures. Iron is excreted in urine and feces.
Folic acid is 64% bound to plasma proteins. The transformation of this substance occurs in the liver. Excreted through the kidneys and intestinal tract.
Indications for use Gyno-Tardiferon
The use of the medication is required when there is a lack of iron and folic acid as a result of the development of anemia.
This process is observed in such cases as:
- gestation period;
- slight or heavy bleeding;
- poor nutrition;
- impaired absorption of iron in the intestinal canal.
It is used not only for the treatment, but also for the prevention of iron deficiency anemia.
For hemorrhoids
The drug is prescribed when blood appears in the stool. During an exacerbation, it quickly replenishes the lack of iron and folic acid. But the product can cause constipation and hardening of stool. Therefore, therapeutic therapy should include the use of suppositories.
The medication is also used for prophylaxis in the chronic form of the disease, as well as after surgery. This allows you to improve the general condition of the patient, relieve fatigue and dizziness. Hemorrhoids decrease in size and bleeding stops.
Contraindications
Although the medicine is considered effective, it cannot be used to treat all patients.
The instructions specify several contraindications in the form of:
- excess iron in the body;
- obstruction of the digestive tract;
- sideroachrastic anemia;
- development of anemia due to lead poisoning;
- anemia of a specific nature;
- increased sensitivity to the active ingredients of the drug;
- esophageal stenosis.
The drug is prescribed with caution for alcoholism, renal and liver failure, stomach disease, and infectious lesions of the lining of the digestive tract.
Side effects from Gyno-Tardiferon
While taking the medication, side symptoms may appear. This process is accompanied by:
- bowel dysfunction;
- flatulence;
- painful feeling in the epigastric region;
- nausea and urge to vomit.
In many cases, the color of the stool changes. They become black or dark in color. In such cases, discontinuation of the drug is not required.
Rarely, darkening of tooth enamel, urticaria, itching and bronchospasm occur. Sometimes anaphylactic shock, weakness, and hot flashes develop.
Overdose
If you strictly adhere to all recommendations, then an overdose will not occur. With increasing doses and prolonged use, an increase in the gag reflex, nausea, and collapse is observed. A dose in the range of 180-300 mg per 1 kg of weight can lead to death.
In case of severe overdose, the patient is prescribed Deferoxamine intramuscularly or intravenously in the form of infusions. Symptomatic therapy is also provided. Hemodialysis is considered effective.
How to take Gyno-Tardiferon?
For minor bleeding from hemorrhoids, 1 tablet is prescribed daily in the morning before meals.
In case of severe bleeding and serious condition of the patient, you need to take 1 piece. 3 times a day.
For prevention in chronic diseases, it is recommended to take 1 tablet once a day. The course lasts for 1-3 months, repeated 2-3 times a year.
Interaction
Increased absorption of active substances occurs when combined with ascorbic acid and ethanol. This can lead to toxic complications.
A decrease in the absorption of iron and folic acid occurs with the simultaneous use of calcium supplements, antacids, and Pancreatin.
Decreased absorption is observed when tablets are taken with meals. Therefore, during treatment it is worth excluding grains, vegetables, tea, coffee, milk and egg yolk from the diet.
special instructions
During the treatment period, the stool turns black or dark in color. This does not affect the general condition of the body in any way and does not pose a threat to life.During antianemic therapy, exacerbation of rheumatoid arthritis may occur. This occurs due to calcium deficiency.
Use in childhood
The instructions for use say that giving the drug to children under 18 years of age is not recommended.
For newborns
If a newborn has an iron deficiency, it is better to choose a safer remedy. Only a pediatrician will help with this.
During pregnancy and lactation
The tablets are allowed to be taken by pregnant women. With a lack of iron, hypoxia occurs in the fetus and mother. To prevent this from happening, it is recommended to use the medicine as a prophylaxis.
During lactation, the medication should be used with caution and only after consultation with a specialist.
Analogs
If the medicine is not commercially available or is not suitable, you can purchase analogues:
- Maltofer.
- Actiferrin.
- Ferrum Lek.
- Ferretab.
Before use, you should read the instructions.
Tardiferon and Gyno-Tardiferon: differences
The drugs differ in that the second drug additionally contains folic acid. Thus, the composition of the blood is completely restored, signs of oxygen starvation and disruption of the nervous system disappear.
Both medications contain ascorbic acid. It helps improve iron absorption.
Terms of sale
You can buy tablets without a doctor's prescription.
Price
The cost of the medicine depends on the region. In Russia, the drug is sold for 245-268 rubles. In Ukraine, the medicine is sold for 115-118 hryvnia.
Storage conditions and shelf life
Tablets are stored in a dark place at temperatures up to +25°C, away from children. The drug is valid for 5 years from the date of manufacture.
4373 0
Gyno-Tardyferon®
Pierre Fabre Medicament Production (France)
Ferrous sulfate/Folic acid
Iron preparations with vitamin
Release form and composition
Tablet, p.o., prolonged action 1 table. contains: tablet core:
active substance: iron (Fe"2+) sulfate x 11/2H2O 256.3 mg (corresponds to 80 mg of iron); excipients: ascorbic acid 30 mg, mucoproteose (anhydrous) 80 mg, potato starch 2 mg, eudragit S 20, 82 mg, dibutyl phthalate 2.08 mg, povidone 17 mg, talc 22 mg, magnesium stearate 2 mg, castor oil 6.5 mg, magnesium trisilicate up to 495 mg; tablet shell:
active substance: folic acid 0.35 mg; excipients: talc 2 mg, titanium dioxide 16 mg, white beeswax 0.18 mg, paraffin wax 0.05 mg, eudragit S 2.5 mg, sucrose up to 710 mg
Mechanism of action
A combined antianemic agent, the effect of which is determined by the properties of the components included in its composition.
Ferrous sulfate is a salt of iron, a trace element necessary for the synthesis of hemoglobin. Iron is part of hemoglobin, myoglobin and a number of enzymes. When iron is used in the form of salts, its deficiency in the body is quickly replenished, which leads to a gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, soreness and dry skin) and laboratory symptoms of anemia.
Folic acid is necessary for normal maturation of megaloblasts and the formation of normoblasts. Stimulates erythropoiesis, participates in the synthesis of amino acids, nucleic acids, purines and pyrimidines, and in choline metabolism. During pregnancy, it protects the body from the effects of teratogenic factors.
Mucoproteose, being a natural high-molecular fraction obtained from the intestinal mucosa of animals and having a certain content of amino sugars and organically bound sulfate, provides better tolerability of drugs from the gastrointestinal tract and increases the bioavailability of iron ions.
Ascorbic acid helps improve iron absorption.
The special neutral coating of the tablets ensures the absorption of active components, mainly from the upper part of the small intestine. The absence of local irritation on the gastric mucosa contributes to good tolerability of the drug in the gastrointestinal tract.
Pharmacokinetics
After oral administration, iron is absorbed from the gastrointestinal tract. The bioavailability of iron is 10-30%. The gradual release of iron allows its absorption to be prolonged, mainly in the distal small intestine. Folic acid is absorbed primarily from the upper gastrointestinal tract (duodenum).
The connection of iron with plasma proteins is 90% or more. Deposited in the form of ferritin or hemosiderin in the cells of the phagocytic macrophage system, a small amount - in the form of myoglobin in muscles. The binding of folic acid to plasma proteins is 64%; biotransformation occurs in the liver.
Iron is excreted in feces, urine and sweat. Folic acid is excreted mainly by the kidneys, partially through the intestines.
Indications
■ Treatment and prevention of iron deficiency anemia of various etiologies (including during pregnancy, impaired absorption of iron from the gastrointestinal tract, prolonged bleeding, poor and unbalanced nutrition).
Directions for use and doses
For mild anemia, 1 tablet is prescribed. daily before breakfast; for moderate anemia - 1 table. 2 times/day; for severe anemia - 1 table. 3 times a day for several weeks (on average 4-5 weeks) - until normal hemoglobin levels are restored. After restoring normal hemoglobin levels, taking drugs should continue for 2-3 months to replenish iron reserves.
To prevent iron and folic acid deficiency during pregnancy and lactation, 1 tablet is prescribed. daily in the second and third trimesters and the postpartum period during breastfeeding.
Contraindications
■ Hypersensitivity to the components of Gyno-Tardiferon®.
■ Anemia not associated with iron or folic acid deficiency (hemolytic anemia, megaloblastic anemia associated with isolated vitamin B12 deficiency).
■ Increased iron content in the body (hemosiderosis).
■ Impaired iron utilization mechanisms (anemia caused by lead poisoning, sideroachrestic anemia).
■ Esophageal stenosis and/or obstructive changes in the gastrointestinal tract.
■ Children's age (under 18 years).
Cautions, therapy monitoring
■ Before starting therapy with Gyno-Tardiferon®, it is necessary to determine the content of iron and ferritin in the blood serum.
■ During the period of taking Gyno-Tardiferon®, a dark coloration of the stool may be observed, which is due to the excretion of unabsorbed iron and has no clinical significance.
Main components: (II) And . Each extended-release tablet contains 256.3 mg of iron sulfate, equivalent to 80 mg of pure iron, and 350 mcg of folic acid.
Additional components: dibutyl phthalate, magnesium stearate, castor oil, talc, anhydrous mucoproteose.
The shell consists of beeswax and titanium dioxide.
Release form
Gyno-Tardiferon is available in tablet form. The tablets have a biconvex shape. The special shell ensures a long, prolonged effect of the drug with a slower release of active components. There are 30 pieces in a package.
pharmachologic effect
Combined hematopoiesis stimulator , antianemic medication .
Ferrous sulfate is an iron salt, which is directly involved in the synthesis process. Iron is found in myoglobin, enzymes, and hemoglobin itself. Taking iron salts allows you to quickly compensate for their deficiency. With iron deficiency, dry skin, rapid heartbeat, fatigue, and severe weakness are noted.
Folic acid takes part in the formation of normoblasts, maturation of megaloblasts, choline metabolism, synthesis of nucleic acids, pyrimidines and purines. During pregnancy, folic acid protects against the effects of teratogenic factors, promoting normal organ formation and fetal development.
Mucoprotease obtained from the intestines of animals, it is a high-molecular fraction of natural origin. Mucoprotease can enhance the bioavailability of iron ions. Ascorbic acid stimulates iron absorption.
The neutral shell of the tablets ensures gradual absorption of the active ingredients in the small intestine, protecting the mucous walls of the stomach from irritation and preventing unwanted side effects from the digestive tract.
Pharmacodynamics and pharmacokinetics
The biological availability of iron reaches 10-30%. In the distal part of the small intestine, slow absorption of the active components occurs. Folic acid begins to be absorbed in the duodenum. Plasma proteins bind to iron by 90%. Deposition occurs in the form of hemosiderin and ferritin, part is deposited in muscle tissue in the form myoglobin . Iron is excreted in sweat, urine and feces.
Folic acid binds to plasma proteins by 64%. Biological transformation occurs in the hepatic system. Folic acid is excreted by the renal system, partially through the intestines.
Indications for use
Replenishment of iron deficiency in the body with:
- anemia ;
- abundant ;
- impaired absorption of iron in the digestive tract.
Contraindications
- hemosiderosis (excess Fe in the body);
- gastrointestinal obstruction;
- sideroachrestic anemia ;
- anemia due to lead poisoning;
- specific anemia (megaloblastic, hemolytic, isolated by vitamin B12 deficiency);
- esophageal stenosis;
- age limit – 18 years.
Side effects
Most often, negative reactions are recorded from the digestive tract:
- stool disorders;
- discomfort in the epigastrium;
- nausea;
- change in stool color;
- vomit.
Darkening of tooth enamel due to the aggressive effects of iron is less common ( temperature increase , bronchospasm ). In isolated cases, anaphylactic reactions, hot flashes, weakness, and fatigue are recorded. Long-term therapy leads to the development of hemosiderosis.
Instructions for Gyno-Tardiferon (Method and dosage)
The medication is taken orally. The preferred time is before meals. It is recommended to drink plenty of liquid and water.
For prevention, 1 tablet is prescribed, the frequency is every 24 hours. For treatment, 1 tablet is prescribed twice a day. The duration of anti-anemic therapy is determined individually, assessing the severity of anemia, the effectiveness of therapy, concomitant diseases, and tolerability of treatment. After normalization of hemoglobin, it is not recommended to stop therapy. The average duration of treatment for anemia is about 3 months after laboratory test values have stabilized.
Overdose
Taking average therapeutic doses cannot lead to an overdose. Main symptoms: gag reflex, nausea; Possible death due to collapse . The lethal dose is 180-300 mg per 1 kg. In the first hours of poisoning, cold sweat, confusion, increased stool frequency, vomiting with blood, cyanotic skin, melena, shock, palpitations, falling and even coma are noted. In some cases, signs are recorded hyperventilation , convulsive syndrome, necrotization of the mucous membranes of the digestive system.
An imaginary improvement may occur after 4-6 hours, but after 12 hours a severe clinical picture of shock develops with symptoms coagulopathies and liver failure. First aid may be to consume milk, raw eggs, which will slow down the absorption of iron by binding to it. Timely gastric lavage with sodium carbonate, saline solution and simultaneous administration of a laxative are effective.
In case of obvious overdose, prescribe Deferoxamine : per os 5-10 grams (dissolve 10-20 ampoules in water). Can be administered parenterally: 1-2 grams intramuscularly every 3-12 hours. It is permissible to use infusions - 1 gram of medication intravenously. It is recommended to carry out syndromic therapy. and peritoneal dialysis have been found to be effective.
Interaction
Iron can slow down the absorption of zinc and . With simultaneous therapy, there is a violation of the absorption of Penicillamine, Carbidopa, Levodopa, Ciprofloxacin. Cholestyramine, antacids, magnesium and calcium reduce the rate of iron absorption. The opposite effect is observed when taking citric acid . The irritating effect of the drug increases when taking NSAIDs. Iron absorption slows down against the background. It is recommended to maintain a one-hour window between doses of drugs. Antimicrobial agents ( , ) are capable of creating fairly stable complexes with Fe sulfate, which significantly impairs iron absorption.
Stimulation erythropoiesis increases with treatment with glucocorticosteroids. The pharmacological activity of the drug decreases when taken. Most antacids, analgesics, sulfonamides, and anticonvulsants impair the absorption of folic acid.
Terms of sale
Gyno-Tardiferon can be purchased without a prescription.
Storage conditions
Restrict admission of children. Temperature - up to 25 degrees Celsius.
Best before date
special instructions
Against the background of antianemic treatment, it may worsen. Regular hematological monitoring of all blood parameters is recommended. When treating patients with teratogenic risk, the pregnancy prognosis worsens and fetal development is disrupted. With a sufficient amount of folic acid, the fetal nervous system is fully formed, and all organs and tissues develop normally. Iron can be excreted in breast milk in small concentrations.
A combined antianemic drug, the effect of which is determined by the properties of the components included in its composition.
Iron sulfate is a salt of iron, a trace element necessary for the synthesis of hemoglobin. Iron is part of hemoglobin, myoglobin and a number of enzymes. When iron is used in the form of salts, its deficiency in the body is quickly replenished, which leads to a gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, soreness and dry skin) and laboratory symptoms of anemia.
Folic acid is necessary for normal maturation of megaloblasts and the formation of normoblasts. Stimulates erythropoiesis, participates in the synthesis of amino acids, nucleic acids, purines and pyrimidines, and in choline metabolism. During pregnancy, it protects the body from the effects of teratogenic factors.
Mucoproteose, being a natural high-molecular fraction obtained from the intestinal mucosa of animals and having a certain content of amino sugars and organically bound sulfate, provides better tolerability of the drug from the gastrointestinal tract and increases the bioavailability of iron ions. Ascorbic acid helps improve iron absorption. The special neutral coating of the tablets ensures the absorption of active components, mainly from the upper part of the small intestine. The absence of local irritation on the gastric mucosa contributes to good tolerability of the drug in the gastrointestinal tract.
Pharmacokinetics
After taking the drug orally, iron is absorbed from the gastrointestinal tract. The bioavailability of iron is 10-30%. The gradual release of iron allows its absorption to be prolonged, mainly in the distal small intestine. Folic acid is absorbed primarily from the upper gastrointestinal tract (duodenum).
Iron binding to plasma proteins is 90% or more. Deposited in the form of ferritin or hemosiderin in the cells of the phagocytic macrophage system, a small amount - in the form of myoglobin in muscles.
The binding of folic acid to plasma proteins is 64%; biotransformation occurs in the liver.
Iron is excreted in feces, urine and sweat.
Folic acid is excreted mainly by the kidneys, partially through the intestines.
Release form
Extended-release tablets, film-coated from white to light beige, biconvex, with a smooth surface; on the cross section it is brown in color with a white edge.
Excipients: ascorbic acid, mucoproteose (anhydrous), potato starch, eudragit S, dibutyl phthalate, povidone, talc, magnesium stearate, hydrogenated castor oil, magnesium trisilicate.
Shell composition: talc, titanium dioxide, white beeswax, solid paraffin, eudragit E, sucrose.
10 pieces. - blisters (3) - cardboard packs.
Dosage
For mild anemia, the drug is prescribed 1 tablet/day before breakfast; for moderate anemia - 1 tablet. 2 times/day; for severe anemia - 1 tablet. 3 times a day for several weeks (on average 4-5 weeks) - until normal hemoglobin levels are restored. After restoring normal hemoglobin levels, the drug should be continued for 2-3 months to replenish iron reserves.
Overdose
Symptoms: the manifestations of the described side effects may increase.
Treatment: gastric lavage with 1% aqueous solution of sodium bicarbonate, symptomatic therapy. The antidote is deferoxamine.
Interaction
Not compatible with other drugs:
Reduce absorption: antacid drugs, calcium supplements, etidronic acid, drugs that reduce the acidity of gastric juice (including cimetidine, drugs containing carbonates, bicarbonates, phosphates, oxalates), pancreatin, pancreolipase, coffee, tea, milk , vegetables, cereals, egg yolk (iron supplements should be taken 1 hour before or 2 hours after their use).
Increase absorption - ascorbic acid, ethanol (including increases the risk of toxic complications).
The drug reduces the absorption of fluoroquinolones, penicillamine, tetracyclines, and in large doses reduces the absorption of zinc preparations (they are recommended to be taken 2 hours before or 2 hours after taking an iron supplement).
Side effects
From the digestive system: rarely - nausea, epigastric pain, diarrhea, constipation.
Indications
- treatment and prevention of iron deficiency anemia of various etiologies (including during pregnancy, with impaired absorption of iron from the gastrointestinal tract, with prolonged bleeding, with inadequate and unbalanced nutrition).
Contraindications
- anemia not associated with iron or folic acid deficiency (hemolytic anemia, megaloblastic anemia associated with isolated deficiency of vitamin B 12);
- increased iron content in the body (hemosiderosis);
- violation of iron utilization mechanisms (anemia caused by lead poisoning, sideroachrestic anemia);
- esophageal stenosis and/or obstructive changes in the gastrointestinal tract;
- children's age (under 18 years);
- hypersensitivity to the components of the drug.
Features of application
Use during pregnancy and breastfeeding
To prevent iron and folic acid deficiency during pregnancy and lactation, the drug is prescribed 1 tablet per day in the II and III trimesters and the postpartum period during breastfeeding.Use for liver dysfunction
The drug should be taken with caution in case of liver failure.Use for renal impairment
The drug should be taken with caution in case of renal failure.Use in children
Contraindicated in children under 18 years of age.special instructions
Before starting drug therapy, it is necessary to determine the content of iron and ferritin in the blood serum.
During the period of taking the drug, a dark coloration of the stool may be observed, which is due to the excretion of unabsorbed iron and has no clinical significance.
The drug should be taken with caution in case of inflammatory bowel diseases, alcoholism, liver or kidney failure.
Active ingredients
Ferrous sulfate x 1 1/2 H 2 O (ferrous sulfate)
- folic acid (vit. B c) (folic acid)
Release form, composition and packaging
Extended-release film-coated tablets from white to light beige, biconvex, with a smooth surface; on the cross section it is brown in color with a white edge.
Excipients: ascorbic acid, mucoproteose (anhydrous), potato starch, eudragit S, dibutyl phthalate, povidone, talc, magnesium stearate, hydrogenated, magnesium trisilicate.
Shell composition: talc, titanium dioxide, white beeswax, solid paraffin, eudragit E, sucrose.
10 pieces. - blisters (3) - cardboard packs.
pharmachologic effect
A combined antianemic drug, the effect of which is determined by the properties of the components included in its composition.
Iron sulfate is a salt of iron, a trace element necessary for the synthesis of hemoglobin. Iron is part of hemoglobin, myoglobin and a number of enzymes. When iron is used in the form of salts, its deficiency in the body is quickly replenished, which leads to a gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, soreness and dry skin) and laboratory symptoms of anemia.
Folic acid is necessary for normal maturation of megaloblasts and the formation of normoblasts. Stimulates erythropoiesis, participates in the synthesis of amino acids, nucleic acids, purines and pyrimidines, and in choline metabolism. During pregnancy, it protects the body from the effects of teratogenic factors.
Mucoproteose, being a natural high-molecular fraction obtained from the intestinal mucosa of animals and having a certain content of amino sugars and organically bound sulfate, provides better tolerability of the drug from the gastrointestinal tract and increases the bioavailability of iron ions. helps improve iron absorption. The special neutral coating of the tablets ensures the absorption of active components, mainly from the upper part of the small intestine. The absence of local irritation on the gastric mucosa contributes to good tolerability of the drug in the gastrointestinal tract.
Pharmacokinetics
After taking the drug orally, iron is absorbed from the gastrointestinal tract. The bioavailability of iron is 10-30%. The gradual release of iron allows its absorption to be prolonged, mainly in the distal small intestine. Folic acid is absorbed primarily from the upper gastrointestinal tract (duodenum).
Iron binding to proteins is 90% or more. Deposited in the form of ferritin or hemosiderin in the cells of the phagocytic macrophage system, a small amount - in the form of myoglobin in muscles.
The binding of folic acid to plasma proteins is 64%; biotransformation occurs in the liver.
Iron is excreted in feces, urine and sweat.
Folic acid is excreted mainly by the kidneys, partially through the intestines.
Indications
- treatment and prevention of iron deficiency anemia of various etiologies (including during pregnancy, with impaired absorption of iron from the gastrointestinal tract, with prolonged bleeding, with inadequate and unbalanced nutrition).
Contraindications
- anemia not associated with iron or folic acid deficiency (hemolytic anemia, megaloblastic anemia associated with isolated B12 deficiency);
- increased iron content in the body (hemosiderosis);
— violation of the mechanisms of iron utilization (anemia caused by lead poisoning, sideroachrestic anemia);
— stenosis of the esophagus and/or obstructive changes in the gastrointestinal tract;
- children's age (under 18 years);
- hypersensitivity to the components of the drug.
Dosage
At mild anemia the drug is prescribed no 1 tablet/day before breakfast; at moderate anemia- 1 tab. 2 times/day; at severe anemia- 1 tab. 3 times a day for several weeks (on average 4-5 weeks) - until normal hemoglobin levels are restored. After restoring normal hemoglobin levels, the drug should be continued for 2-3 months to replenish iron reserves.
For prevention of iron and folic acid deficiency during pregnancy and lactation the drug is prescribed 1 tablet/day in the second and third trimesters and the postpartum period during breastfeeding.
Side effects
From the digestive system: rarely - nausea, epigastric pain, diarrhea, constipation.
Overdose
Symptoms: the manifestations of the described side effects may increase.
Treatment: gastric lavage with a 1% aqueous solution, symptomatic therapy. The antidote is deferoxamine.
Drug interactions
Not compatible with other drugs:
Reduce absorption: antacid drugs, calcium supplements, etidronic acid, drugs that reduce the acidity of gastric juice (including cimetidine, drugs containing carbonates, bicarbonates, phosphates, oxalates), pancreatin, pancreolipase, coffee, tea, milk , vegetables, cereals, egg yolk (iron supplements should be taken 1 hour before or 2 hours after their use).
Increase absorption - ascorbic acid, ethanol (including increases the risk of toxic complications).
The drug reduces the absorption of fluoroquinolones, penicillamine, tetracyclines, and in large doses reduces the absorption of zinc preparations (they are recommended to be taken 2 hours before or 2 hours after taking an iron supplement).
