In this article you can read the instructions for use of the drug Deoxyribonuclease. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Deoxyribonuclease in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Deoxyribonuclease analogues in the presence of existing structural analogues. Use for the treatment of eye herpes, adenovirus infection, bronchiectasis, pneumonia in adults, children, as well as during pregnancy and lactation.
Deoxyribonuclease- an enzyme contained in the pancreas and intestinal mucosa; albumin type protein. Hydrolyzes (depolymerizes) deoxyribonucleic acid (DNA) to form deoxyribonucleotides. The drug is obtained from the pancreas of cattle. It is a lyophilized white powder, soluble in water and isotonic sodium chloride solution. Activity is determined by the formation of acid-soluble products released by the drug from DNA under certain conditions; it is expressed in activity units (EA). 1 mg of the drug must contain at least 1700 EA. Deoxyribonuclease has the ability to delay the development of herpes viruses, adenoviruses and other viruses containing DNA. The effect is associated with the depolymerization of DNA into mono- and oligonucleotides by cleavage of internucleotide bonds. While suppressing the synthesis of viral DNA, deoxyribonuclease does not damage the DNA of the host cells. Deoxyribonuclease also causes depolymerization and liquefaction of pus.
Compound
Deoxyribonuclease + excipients.
Indications
- herpetic keratitis and keratouveitis;
- adenoviral conjunctivitis and keratitis;
- acute catarrhal inflammation of the upper respiratory tract of adenoviral nature (adenoviral infection);
- bronchiectasis, lung abscess, atelectasis, pneumonia (to reduce viscosity and improve the evacuation of sputum and pus);
- in the preoperative and postoperative periods in patients with purulent lung diseases, pulmonary tuberculosis.
Release forms
Lyophilisate for the preparation of solutions of 5 mg, 10 mg, 25 mg and 50 mg for injection (injections in ampoules) and topical use.
Instructions for use and dosage regimen
For external use, use Deoxyribonuclease in the form of a 0.2% solution (2 mg of the drug in 1 ml) in an isotonic sodium chloride solution. Solutions are prepared daily, the shelf life of the solution is 12 hours.
For herpetic keratitis and keratouveitis, 0.5 ml of a sterile deoxyribonuclease solution is injected daily under the conjunctiva of the affected eye for 2-4 weeks. In addition, 2-3 drops of a 0.2% solution are instilled into the eye 3-4 times a day. To prevent relapses, continue to administer the drug for 6-10 days after persistent clinical improvement.
To treat adenoviral keratoconjunctivitis, 1-2 drops of a 0.05% solution in distilled water are injected into the conjunctival cavity every 1.5-2 hours during the day.
In case of acute catarrhal inflammation of the upper respiratory tract of an adenoviral nature, the solution is instilled into the nose or administered as an aerosol. Inhalations for 10-15 minutes are performed 2-3 times a day for 2-5 days. For each inhalation - 3 ml of 0.2% solution.
In case of suppurative processes in the lungs, the solution is administered into the respiratory tract in the form of an aerosol at the rate of 1 ml of solution for 10-15 minutes. About 3 ml of solution is consumed for each inhalation. Inhalations are performed 3 times a day for 7-8 days.
For the treatment of herpetic skin diseases in adults, 50 mg of Deoxyribonuclease in 5 ml of saline or novocaine (0.25% or 0.5%) is administered intramuscularly every 4 hours for 3-10 days.
Side effect
- allergic reactions (with local application);
- increased frequency of attacks in patients with bronchial asthma, which requires a break in treatment or complete discontinuation of the drug.
Contraindications
- individual hypersensitivity to the components of the drug.
Use during pregnancy and breastfeeding
The use of Deoxyribonuclease in pregnant and lactating women has not been described.
Use in children
There is no information on the use of Deoxyribonuclease in children.
special instructions
An aqueous solution (and powder) of Deoxyribonucleases are inactivated when heated above +55 degrees Celsius.
There is evidence of the positive effect of Deoxyribonuclease in acute viral hepatitis, Kaposi's eczema herpetiformis, and other diseases. In these cases, the drug is used parenterally. The issue of parenteral use of the drug requires further study.
Drug interactions
No significant interaction of Deoxyribonuclease with other drugs has been described.
Analogues of the drug Deoxyribonuclease
The drug Deoxyribonuclease has no structural analogs of the active substance.
Analogs of the drug Deoxyribonuclease by pharmacological group (dermatotropic agents):
- Adaklin;
- Adapalene;
- Adolen;
- Azelik;
- Alerana;
- Allomedine;
- Alopexy;
- Algipor;
- Anmarin;
- Afloderm;
- Belobaza;
- Bepanten plus;
- Berestin;
- Biopin;
- Verocutan;
- Vinisol;
- Virosept;
- Vitaon;
- Vulnuzan;
- Generolon;
- Hydroquinone;
- Glenriaz;
- Glycolan;
- Glycerol;
- Daivobet;
- Daivonex;
- Dexeryl;
- Dexpanthenol;
- Dermaref;
- Desitin;
- Desquam;
- Dimexide;
- Differin;
- Dufilm;
- Indoxyl;
- Iricar;
- Kamagel;
- Keratolan;
- Klenzit;
- Cleore;
- Collomak;
- Xamiol;
- Linin;
- Lokacid;
- Losterol;
- Minoxidil;
- Mozoil;
- Naftaderm;
- Neotigazon;
- Sea buckthorn oil;
- Oxoralen;
- Paxemol;
- Proderm;
- Protopic;
- Radevit;
- Revasil;
- Retasol;
- Retinoic ointment;
- Roaccutane;
- Silocast;
- Skinoren;
- Solcoderm;
- Tretinoin;
- Uroderm;
- Cygnoderm;
- Tsinocap;
- Egallohit;
- Elidel;
- Eftiderm;
- Effezel.
Review from an ophthalmologist
I sometimes prescribe deoxyribonuclease to patients with herpetic eye lesions, namely herpetic uveitis and keratoconjunctivitis. Patients instill a medicinal solution into their eyes. I do not practice administering the drug under the conjunctiva. But I cannot say anything specific about the effectiveness of Deoxyribonuclease specifically, since all patients with this pathology receive complex therapy, against the background of which a noticeable improvement in their condition is noted. There have been no allergic reactions to Deoxyribonuclease in my practice.
If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.
Release form, composition and packaging
Deoxyribonuclease is an enzyme found in the pancreas and intestinal mucosa; albumin type protein.
Hydrolyzes (depolymerizes) DNA to form deoxyribonucleotides. For medical use it is obtained from the pancreas of cattle. It is a lyophilized white powder, soluble in water and isotonic sodium chloride solution; pH of 0.1% aqueous solution is 3.0-5.5. Aqueous solutions (and powder) are inactivated when heated above +55°C.
Activity is determined by the formation of acid-soluble products released by the drug from DNA under certain conditions; it is expressed in activity units (EA). 1 mg of the drug must contain at least 1700 EA. Preparations similar in action to deoxyribonuclease are produced abroad under the names "Pancreatic dornase", "Dornavac", etc. They are produced in hermetically sealed bottles containing 5; 10; 25 and 50 mg.
pharmachologic effect
Deoxyribonuclease has the ability to delay the development of herpes viruses, adenoviruses and other viruses containing DNA. The effect is associated with the depolymerization of DNA into mono- and oligonucleotides by cleavage of internucleotide bonds. While suppressing the synthesis of viral DNA, deoxyribonuclease does not damage the DNA of the host cells.
Deoxyribonuclease also causes depolymerization and liquefaction of pus.
Indications
Used for herpetic keratitis and keratouveitis, adenoviral conjunctivitis and keratitis, lung abscesses, acute catarrhal inflammation of the upper respiratory tract of adenoviral nature; to reduce viscosity and improve the evacuation of sputum and pus in bronchiectasis, lung abscesses, atelectasis, pneumonia; in the preoperative and postoperative periods in patients with purulent lung diseases, pulmonary tuberculosis.
Dosage regimen
For external use, deoxyribonuclease is used in the form of a 0.2% solution (2 mg of the drug in 1 ml) in an isotonic sodium chloride solution. Solutions are prepared daily; The shelf life of the solution is 12 hours. For herpetic keratitis and keratouveitis, 0.5 ml of a sterile deoxyribonuclease solution is injected daily under the conjunctiva of the affected eye for 2-4 weeks.
In addition, 2-3 drops of a 0.2% solution are instilled into the eye 3-4 times a day. To prevent relapses, continue to administer the drug for 6-10 days after persistent clinical improvement. To treat adenoviral keratoconjunctivitis, 1-2 drops of a 0.05% solution in distilled water are injected into the conjunctival cavity every 1.5-2 hours during the day.
In case of acute catarrhal inflammation of the upper respiratory tract of an adenoviral nature, the solution is instilled into the nose or administered as an aerosol; inhalations for 10-15 minutes are performed 2-3 times a day for 2-5 days. For each inhalation - 3 ml of 0.2% solution.
In the case of suppurative processes in the lungs, the solution is administered into the respiratory tract in the form of an aerosol at the rate of 1 ml of solution for 10-15 minutes. About 3 ml of solution is consumed for each inhalation. Inhalations are performed 3 times a day for 7-8 days. There is evidence of the positive effect of deoxyribonuclease in acute viral hepatitis, Kaposi's eczema herpetiformis, and other diseases. In these cases, the drug is used parenterally. The issue of parenteral use of the drug requires further study.
Side effect
With topical use of deoxyribonuclease, allergic reactions are possible in some cases. Patients with bronchial asthma may experience an increase in attacks, which requires a break in treatment or complete discontinuation of the drug. In case of individual hypersensitivity, the drug is discontinued.
Storage conditions and periods
In a dry place, protected from light, at a temperature not exceeding +20°C.
Name: Deoxyribonuclease
Name: Deoxyribonucleasa
Indications for use:
Herpetic keratitis and keratovsitis (combined inflammation of the cornea and choroid of the eyeball caused by the herpes virus), adenoviral conjunctivitis and keratitis (inflammation of the outer membrane of the eyeball and cornea caused by adenovirus), acute catarrh (inflammation of the mucous membranes) of the upper respiratory tract of adenoviral nature, necessity reducing viscosity and improving the evacuation of sputum and pus in bronchiectasis (a disease of the bronchi associated with the expansion of their lumen), lung abscesses (lung ulcers), atelectasis (collapse of lung tissue), pneumonia (pneumonia).
Pharmachologic effect:
Liquefies pus, delays the development of viruses (herpes, adenoviruses and other viruses containing deoxyribonucleic acid).
Deoxyribonuclease method of administration and dosage:
For eye diseases, 0.5 ml is injected under the conjunctiva (under the outer shell of the eye) every day for 2-4 weeks. or instill 2-3 drops of a 0.2% solution into the eye 3-4 times every day or 1-2 drops of a 0.05% solution every 11/2-2 hours throughout the day. For acute catarrh of the upper respiratory tract, the solution is instilled into the nose or used in the form of an aerosol; inhalations for 10-15 minutes are prescribed 2-3 times over 2-5 days (3 ml of 0.2% solution is used for inhalation). For lung diseases, 3 ml of solution is administered into the respiratory tract in the form of an aerosol (1 ml for 10-15 minutes) 3 times every day for 7-8 days.
In the pre- and postoperative period, patients with purulent diseases and pulmonary tuberculosis are prescribed the product in the form of a 0.2% solution (2 mg in 1 ml) in an isotonic sodium chloride solution.
Release form:
In bottles containing 10 mg and 25 mg; 1 mg corresponds to 5 activity units (EA).
Deoxyribonuclease side effects:
Allergic reactions are possible. People with bronchial asthma may experience an increase in attacks.
Storage conditions:
In a dry place, protected from light, at a temperature not exceeding +20 ° C.
Deoxyribonuclease composition:
Deoxyribonuclease is an enzyme found in the pancreas and intestinal mucosa; albumin type protein.
Hydrolyzes (depolymerizes) DNA to form deoxyribonucleotides. For medical use it is obtained from the pancreas of cattle. It is a lyophilized white powder, soluble in water and isotonic sodium chloride solution; pH of 0.1% aqueous solution 3.0 - 5.5. Aqueous solutions (and powder) are inactivated when heated above +55 *C.
Synonyms:
Dornavak.
Attention!
Before using the medication "Deoxyribonuclease" you should consult your doctor.
The instructions are provided for informational purposes only. Deoxyribonuclease».
Deoxyribonucleasa
pharmachologic effect
Liquefies pus, delays the development of viruses (herpes, adenoviruses and other viruses containing deoxyribonucleic acid).
Indications for use
Herpetic keratitis and keratovsitis (combined inflammation of the cornea and choroid of the eyeball caused by the herpes virus), adenoviral conjunctivitis and keratitis (inflammation of the outer membrane of the eyeball and cornea caused by adenovirus), acute catarrh (inflammation of the mucous membranes) of the upper respiratory tract of adenoviral nature, necessity reducing viscosity and improving the evacuation of sputum and pus in bronchiectasis (a disease of the bronchi associated with the expansion of their lumen), lung abscesses (lung ulcers), atelectasis (collapse of lung tissue), pneumonia (pneumonia).
Mode of application
For eye diseases, 0.5 ml is injected under the conjunctiva (under the outer shell of the eye) daily for 2-4 weeks. or instill 2-3 drops of a 0.2% solution into the eye 3-4 times a day or 1-2 drops of a 0.05% solution every 11/2-2 hours during the day. For acute catarrh of the upper respiratory tract, the solution is instilled into the nose or used in the form of an aerosol; inhalations for 10-15 minutes are prescribed 2-3 times over 2-5 days (3 ml of 0.2% solution is used for inhalation). For lung diseases, 3 ml of solution is administered into the respiratory tract in the form of an aerosol (1 ml for 10-15 minutes) 3 times a day for 7-8 days.
In the pre- and postoperative period, patients with purulent diseases and pulmonary tuberculosis are prescribed the drug in the form of a 0.2% solution (2 mg per 1 ml) in an isotonic sodium chloride solution.
Side effects
Allergic reactions are possible. In patients with bronchial asthma, attacks may become more frequent.
Release form
In bottles containing 10 mg and 25 mg; 1 mg corresponds to 5 activity units (EA).
Storage conditions
In a dry place, protected from light, at a temperature not exceeding +20 ° C.
Synonyms
Dornavak.
Compound
Deoxyribonuclease is an enzyme found in the pancreas and intestinal mucosa; albumin type protein.
Hydrolyzes (depolymerizes) DNA to form deoxyribonucleotides. For medical use it is obtained from the pancreas of cattle. It is a lyophilized white powder, soluble in water and isotonic sodium chloride solution; pH of 0.1% aqueous solution 3.0 - 5.5. Aqueous solutions (and powder) are inactivated when heated above +55 *C.
Attention
Before using the drug Deoxyribonuclease you should consult your doctor. This instruction is given in free translation and is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions.
DeoxyribonucleasaCompound
Deoxyribonuclease is an enzyme found in the pancreas and intestinal mucosa; albumin type protein.Hydrolyzes (depolymerizes) DNA to form deoxyribonucleotides. For medical use it is obtained from the pancreas of cattle. It is a lyophilized white powder, soluble in water and isotonic sodium chloride solution; pH of 0.1% aqueous solution 3.0 - 5.5. Aqueous solutions (and powder) are inactivated when heated above +55 *C.
pharmachologic effect
Liquefies pus, delays the development of viruses (herpes, adenoviruses and other viruses containing deoxyribonucleic acid).Indications for use
Herpetic keratitis and keratovsitis (combined inflammation of the cornea and choroid of the eyeball caused by the herpes virus), adenoviral conjunctivitis and keratitis (inflammation of the outer membrane of the eyeball and cornea caused by adenovirus), acute catarrh (inflammation of the mucous membranes) of the upper respiratory tract of adenoviral nature, necessity reducing viscosity and improving the evacuation of sputum and pus in bronchiectasis (a disease of the bronchi associated with the expansion of their lumen), lung abscesses (lung ulcers), atelectasis (collapse of lung tissue), pneumonia (pneumonia).Mode of application
For eye diseases, 0.5 ml is injected under the conjunctiva (under the outer shell of the eye) daily for 2-4 weeks. or instill 2-3 drops of a 0.2% solution into the eye 3-4 times a day or 1-2 drops of a 0.05% solution every 11/2-2 hours during the day. For acute catarrh of the upper respiratory tract, the solution is instilled into the nose or used in the form of an aerosol; inhalations for 10-15 minutes are prescribed 2-3 times over 2-5 days (3 ml of 0.2% solution is used for inhalation). For lung diseases, 3 ml of solution is administered into the respiratory tract in the form of an aerosol (1 ml for 10-15 minutes) 3 times a day for 7-8 days.In the pre- and postoperative period, patients with purulent diseases and pulmonary tuberculosis are prescribed the drug in the form of a 0.2% solution (2 mg per 1 ml) in an isotonic sodium chloride solution.
Side effects
Allergic reactions are possible. In patients with bronchial asthma, attacks may become more frequent.Release form
In bottles containing 10 mg and 25 mg; 1 mg corresponds to 5 activity units (EA).Storage conditions
In a dry place, protected from light, at a temperature not exceeding +20 ° C.Synonyms
Dornavak.Active substance:
deoxyribonucleaseAuthors
Links
- Official instructions for the drug Deoxyribonuclease.
- Modern drugs: a complete practical guide. Moscow, 2000. S. A. Kryzhanovsky, M. B. Vititnova.
Description of the drug " Deoxyribonuclease"on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
