Home Children's dentistry Drug: Salazopyridazine. Salazopyridazine: reviews, analogs, instructions, where to buy Characteristics of salazopyridazine as a pharmaceutical drug used in medical practice

Children's dentistry

Drug: Salazopyridazine. Salazopyridazine: reviews, analogs, instructions, where to buy Characteristics of salazopyridazine as a pharmaceutical drug used in medical practice

International name

Mesalazine

Group affiliation

Antimicrobial and anti-inflammatory intestinal agent

Dosage form

Rectal suppositories, oral suspension, rectal suspension, tablets, enteric-coated tablets, extended-release tablets

pharmachologic effect

It has an antioxidant effect (due to the ability to bind to free oxygen radicals and destroy them). It is well tolerated and reduces the risk of relapse in Crohn's disease, especially in patients with ileitis and a long duration of the disease.

Indications

Nonspecific ulcerative colitis, Crohn's disease (prevention and treatment of exacerbations).

Contraindications

Hypersensitivity (when using enemas, including to methyl and propylparaben), blood diseases, peptic ulcer stomach and duodenum, glucose-6-phosphate dehydrogenase deficiency, hemorrhagic diathesis, severe renal/liver failure, lactation period, last 2-4 weeks of pregnancy, childhood(up to 2 years). With caution. Pregnancy (first trimester), liver and/or kidney failure.

Side effects

From the outside digestive system: nausea, vomiting, heartburn, diarrhea, loss of appetite, abdominal pain, dry mouth, stomatitis, increased activity of liver transaminases, hepatitis, pancreatitis.

From the cardiovascular system: palpitations, tachycardia, increased or decreased blood pressure, chest pain, shortness of breath.

From the outside nervous system: headache, tinnitus, dizziness, polyneuropathy, tremor, depression.

From the urinary system: proteinuria, hematuria, oliguria, anuria, crystalluria, nephrotic syndrome.

Allergic reactions: skin rash, itching, dermatoses (pseudoerythromatosis), bronchospasm.

From the hematopoietic organs: eosinophilia, anemia (hemolytic, megaloblastic, aplastic), leukopenia, agranulocytosis, thrombocytopenia, hypoprothrombinemia.

Other: weakness, mumps, photosensitivity, lupus-like syndrome, oligospermia, alopecia, decreased production of tear fluid.

Application and dosage

Choice dosage form determined by the location and extent of intestinal damage.

For common forms, tablets are used, for distal forms (proctitis, proctosigmoiditis) - rectal forms. In case of exacerbation of the disease - 400-800 mg 3 times a day, for 8-12 weeks. To prevent relapses - 400-500 mg 3 times a day for nonspecific ulcerative colitis and 1 g 4 times a day – for Crohn’s disease; children over 2 years old - 20-30 mg/kg/day in several doses for several years. In severe cases of the disease, the daily dose can be increased to 3-4 g, but not more than for 8-12 weeks. The tablets should be taken whole, without chewing, after meals, with plenty of liquid.

Suppositories - 500 mg 3 times a day, and suspension - 60 g of suspension (4 g of mesalazine) 1 time per day at night, in the form of a medicinal microenema (it is recommended to cleanse the intestines first).

For children, suppositories are prescribed at the following rate: for exacerbation - 40-60 mg/kg/day; for maintenance therapy – 20-30 mg/kg/day.

special instructions

It is advisable to carry out regular general analysis blood (before, during, and after treatment) and urine, monitoring the excretory function of the kidneys. Patients who are “slow acetylators” have increased risk development side effects. There may be a yellow-orange coloration of urine and tears, staining of soft contact lenses. If you miss a dose, the missed dose should be taken at any time or with the next dose. If several doses are missed, then, without stopping treatment, consult a doctor. If the development of acute intolerance syndrome is suspected, mesalazine should be discontinued.

Interaction

It enhances the hypoglycemic effect of sulfonylurea derivatives, the ulcerogenicity of GCS, the toxicity of methotrexate, weakens the activity of furosemide, spironolactone, sulfonamides, rifampicin, enhances the effect of anticoagulants, increases the effectiveness of uricosuric drugs (tubular secretion blockers). Slows down the absorption of cyanocobalamin.

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Mesalazine

Salazopyridazine:: Dosage form

rectal suppositories, oral suspension, rectal suspension, tablets, enteric-coated tablets, extended-release tablets

Salazopyridazine:: Pharmacological action

It has local anti-inflammatory properties (due to inhibition of the activity of neutrophil lipoxygenase and the synthesis of Pg and leukotrienes). Inhibits migration, degranulation, phagocytosis of neutrophils, as well as secretion of Ig by lymphocytes. It has an antibacterial effect against E. coli and some cocci (manifests in the large intestine). It has an antioxidant effect (due to the ability to bind to free oxygen radicals and destroy them). It is well tolerated and reduces the risk of relapse in Crohn's disease, especially in patients with ileitis and a long duration of the disease.

Salazopyridazine:: Indications

Nonspecific ulcerative colitis, Crohn's disease (prevention and treatment of exacerbations).

Salazopyridazine:: Contraindications

Hypersensitivity (when using enemas, including to methyl and propylparaben), blood diseases, peptic ulcer of the stomach and duodenum, deficiency of glucose-6-phosphate dehydrogenase, hemorrhagic diathesis, severe renal/liver failure, lactation period, the latter 2-4 weeks of pregnancy, children's age (up to 2 years). With caution. Pregnancy (first trimester), liver and/or kidney failure.

Salazopyridazine:: Side effects

From the digestive system: nausea, vomiting, heartburn, diarrhea, loss of appetite, abdominal pain, dry mouth, stomatitis, increased activity of liver transaminases, hepatitis, pancreatitis. From the cardiovascular system: palpitations, tachycardia, increased or decreased blood pressure, chest pain, shortness of breath. From the nervous system: headache, tinnitus, dizziness, polyneuropathy, tremor, depression. From the urinary system: proteinuria, hematuria, oliguria, anuria, crystalluria, nephrotic syndrome. Allergic reactions: skin rash, itching, dermatoses (pseudoerythromatosis), bronchospasm. From the hematopoietic organs: eosinophilia, anemia (hemolytic, megaloblastic, aplastic), leukopenia, agranulocytosis, thrombocytopenia, hypoprothrombinemia. Other: weakness, mumps, photosensitivity, lupus-like syndrome, oligospermia, alopecia, decreased tear production. Overdose. Symptoms: nausea, vomiting, gastralgia, weakness, drowsiness. Treatment: gastric lavage, laxative administration, symptomatic therapy.

Salazopyridazine:: Method of administration and dosage

The choice of dosage form is determined by the location and extent of intestinal damage. For common forms, tablets are used, for distal forms (proctitis, proctosigmoiditis) - rectal forms. In case of exacerbation of the disease - 400-800 mg 3 times a day, for 8-12 weeks. To prevent relapses - 400-500 mg 3 times a day for nonspecific ulcerative colitis and 1 g 4 times a day for Crohn's disease; children over 2 years old - 20-30 mg/kg/day in several doses for several years. In severe cases of the disease, the daily dose can be increased to 3-4 g, but not more than for 8-12 weeks. The tablets should be taken whole, without chewing, after meals, with plenty of liquid. Suppositories - 500 mg 3 times a day, and suspension - 60 g of suspension (4 g of mesalazine) 1 time per day at night, in the form of a medicinal microenema (it is recommended to cleanse the intestines first). For children, suppositories are prescribed at the following rate: for exacerbation - 40-60 mg/kg/day; for maintenance therapy - 20-30 mg/kg/day.

Salazopyridazine:: Special instructions

It is advisable to regularly conduct a general blood test (before, during, and after treatment) and urine, and monitor the excretory function of the kidneys. Patients who are “slow acetylators” have an increased risk of developing side effects. There may be a yellow-orange coloration of urine and tears and staining of soft contact lenses. If you miss a dose, the missed dose should be taken at any time or with the next dose. If several doses are missed, then, without stopping treatment, consult a doctor. If the development of acute intolerance syndrome is suspected, mesalazine should be discontinued.

Salazopyridazine:: Interactions

For nonspecific ulcerative colitis, salazopyridazine is prescribed to adults orally (after meals) in tablets of 0.5 g 4 times every day for 3-4 weeks. If during this period a therapeutic effect appears, the daily dose is reduced to 1.0-1.5 g (0.5 g 2-3 times every day) and treatment is continued for another 2-3 weeks. If there is no effect, stop taking the product. Patients with light forms disease, the product is first prescribed in a daily dose of 1.5 g, and if there is no effect, the dose is increased to 2 g per day. For children aged 3 to 5 years, salazopyridazine is prescribed starting with a dose of 0.5 g per day (2-3 doses). If there is no effect within 2 weeks. The product is canceled, and when... Availability therapeutic effect continue treatment at this dose for 5-7 days, then reduce the dose by 2 times and continue treatment for another 2 weeks. In the case of clinical remission (temporary weakening or disappearance of the manifestations of the disease), the daily dose is again reduced by half and prescribed until the 40-50th day, counting from the start of treatment. Children aged 5 to 7 years are prescribed the product starting from 0.75-1.0 g per day; from 7 to 15 years - with a dose of 1.0-1.2-1.5 g per day. Treatment and dose reduction are carried out according to the same scheme as for children from 3 to 5 years old. The use of salazopyridazine is combined with general methods treatment and diet recommended for ulcerative colitis. Salazopyridazine can also be used for ulcerative colitis and Crohn's disease (a disease of unknown cause characterized by inflammation and narrowing of the lumen of certain parts of the intestine) rectally (into the rectum) in the form of suspensions (a suspension of solid particles in a liquid) and suppositories. Salazopyridazine suspension 5% is used for rectal administration in cases of damage to the rectum and sieve, in the preoperative period and after subtotal colectomy (after removal of part colon), if the product in tablet form is poorly tolerated. The suspension is slightly heated and administered as an enema into the rectum or intestinal stump, 20-40 ml 1-2 times a day. Children are administered 10-20 ml (depending on age). Rectal administration can be combined with oral administration of the substance. Suppositories are used rectally. IN acute stage diseases are prescribed 1 suppository 2-4 times every day for 2 weeks. Up to 3 months The duration of the course depends on the effectiveness of treatment and tolerability of the product. The maximum daily dose is 4 suppositories (2 g). At the same time, you can take salazopyridazine tablets (not exceeding the total daily dose 3 d) and other drugs for the treatment of ulcerative colitis. In order to prevent relapses (reappearance of signs of the disease), 1-2 suppositories are prescribed per day for 2-3 months. The dosage and regimen of the product for other forms of colitis with ulcerative lesions are the same as for nonspecific ulcerative colitis.

Indications for use:
Nonspecific ulcerative colitis ( chronic inflammation colon with the formation of ulcers caused by unclear reasons), also in diseases occurring with autoimmune disorders (disorders based on allergic reactions on the body’s own tissues or waste products), including as a basic agent in therapy rheumatoid arthritis(an infectious-allergic disease from the group of collagenoses, characterized by chronic progressive inflammation of the joints).

Pharmachologic effect:
Sulfanilamyl product. It has an anti-inflammatory and immunosuppressive (suppressing the body's defenses) effect.

Salazopyridazine method of administration and dosage:
For nonspecific ulcerative colitis, salazopyridazine is prescribed to adults orally (after meals) in tablets of 0.5 g 4 times every day for 3-4 weeks. If during this period a therapeutic effect appears, the daily dose is reduced to 1.0-1.5 g (0.5 g 2-3 times every day) and treatment is continued for another 2-3 weeks. If there is no effect, stop taking the product. For patients with mild forms of the disease, the product is first prescribed at a daily dose of 1.5 g, and if there is no effect, the dose is increased to 2 g per day.
For children aged 3 to 5 years, salazopyridazine is prescribed starting with a dose of 0.5 g per day (2-3 doses). If there is no effect within 2 weeks. the product is discontinued, and if there is a therapeutic effect, treatment is continued at this dose for 5-7 days, then the dose is reduced by 2 times and treatment is continued for another 2 weeks. In the case of clinical remission (temporary weakening or disappearance of the manifestations of the disease), the daily dose is again reduced by half and prescribed until the 40-50th day, counting from the start of treatment.
Children aged 5 to 7 years are prescribed the product starting from 0.75-1.0 g per day; from 7 to 15 years - with a dose of 1.0-1.2-1.5 g per day. Treatment and dose reduction are carried out according to the same scheme as for children from 3 to 5 years old.
The use of salazopyridazine is combined with general treatment methods and diet recommended for nonspecific ulcerative colitis.
Salazopyridazine can also be used for ulcerative colitis and Crohn's disease (a disease of unknown cause characterized by inflammation and narrowing of the lumen of certain parts of the intestine) rectally (into the rectum) in the form of suspensions (a suspension of solid particles in a liquid) and suppositories.
Salazopyridazine suspension 5% is used for rectal administration in cases of damage to the rectum and sieve, in the preoperative period and after subtotal colectomy (after removal of part of the colon), with poor tolerability of the product in tablet form. The suspension is slightly heated and administered as an enema into the rectum or intestinal stump, 20-40 ml 1-2 times a day. Children are administered 10-20 ml (depending on age). Rectal administration can be combined with oral administration of the substance.
Suppositories are used rectally. In the acute stage of the disease, 1 suppository is prescribed 2-4 times every day for 2 weeks. up to 3 months The duration of the course depends on the effectiveness of treatment and tolerability of the product. The maximum daily dose is 4 suppositories (2 g). At the same time, you can take salazopyridazine tablets (not exceeding a total daily dose of 3 g) and other drugs for the treatment of ulcerative colitis.
In order to prevent relapses (reappearance of signs of the disease), 1-2 suppositories are prescribed per day for 2-3 months.
The dosage and regimen of the product for other forms of colitis with ulcerative lesions are the same as for nonspecific ulcerative colitis.

Salazopyridazine contraindications:
The drug is contraindicated if there is a history (medical history) of toxic-allergic reactions during treatment with sulfonamides and salicylates.

Salazopyridazine side effects:
When taking salazopyridazine tablets orally, the same adverse reactions that when using sulfonamides and salicylates: allergic phenomena, leukopenia (decrease in the level of leukocytes in the blood), dyspeptic disorders (digestive disorders), sometimes a slight decrease in hemoglobin levels ( functional structure erythrocyte, ensuring its interaction with oxygen). In such cases, the dose should be reduced or the product discontinued. After administration of the suspension, a burning sensation in the rectum and the urge to defecate (bowel movement) may appear, especially with rapid administration. When using salazopyridazine in suppositories, there may be a burning sensation and pain in the rectum, and sometimes increased bowel movements. In case of severe pain during rectal administration of salazopyridazine in suppositories, it is recommended to administer the product rectally in the form of a 5% suspension and orally in tablets.

Salazopyridazine (Salazopyridazinum)

Compound

Active ingredient: sulfasalazine, excipients.

pharmachologic effect

Sulfanilamyl drug. It has an anti-inflammatory and immunosuppressive (suppressing the body's defenses) effect.

Indications for use

Nonspecific ulcerative colitis (chronic inflammation of the colon with the formation of ulcers, caused by unclear reasons), as well as in diseases occurring with autoimmune disorders (disorders based on allergic reactions to the body’s own tissues or waste products), including as a basic agents in the treatment of rheumatoid arthritis (an infectious-allergic disease from the group of collagenoses, characterized by chronic progressive inflammation of the joints).

Mode of application

For nonspecific ulcerative colitis, adults are prescribed salazopyridazine orally (after meals) in tablets of 0.5 g 4 times a day for 3-4 weeks. If during this period a therapeutic effect appears, the daily dose is reduced to 1.0-1.5 g (0.5 g 2-3 times a day) and treatment is continued for another 2-3 weeks. If there is no effect, stop taking the drug. For patients with mild forms of the disease, the drug is first prescribed at a daily dose of 1.5 g, and if there is no effect, the dose is increased to 2 g per day.
For children aged 3 to 5 years, salazopyridazine is prescribed starting with a dose of 0.5 g per day (2-3 doses). If there is no effect within 2 weeks. the drug is discontinued, and if there is a therapeutic effect, treatment is continued at this dose for 5-7 days, then the dose is reduced by 2 times and treatment is continued for another 2 weeks. In the case of clinical remission (temporary weakening or disappearance of the manifestations of the disease), the daily dose is again reduced by half and prescribed until the 40-50th day, counting from the start of treatment.
Children aged 5 to 7 years are prescribed the drug, starting from 0.75-1.0 g per day; from 7 to 15 years - with a dose of 1.0-1.2-1.5 g per day. Treatment and dose reduction are carried out according to the same scheme as in children from 3 to 5 years old.
The use of salazopyridazine is combined with general treatment methods and diet recommended for nonspecific ulcerative colitis.
Salazopyridazine can also be used for ulcerative colitis and Crohn's disease (a disease of unknown cause, characterized by inflammation and narrowing of the lumen of certain parts of the intestine) rectally (into the rectum) in the form of suspensions (a suspension of solid particles in liquid) and suppositories.
A 5% salazopyridazine suspension is used for rectal administration in cases of damage to the rectum and sieve, in the preoperative period and after subtotal colectomy (after removal of part of the colon), if the drug in tablet form is poorly tolerated. The suspension is slightly heated and administered as an enema into the rectum or intestinal stump, 20-40 ml 1-2 times a day. Children are administered 10-20 ml (depending on age). Rectal administration can be combined with oral administration of the drug.
Suppositories are used rectally. In the acute stage of the disease, 1 suppository is prescribed 2-4 times a day for 2 weeks. up to 3 months The duration of the course depends on the effectiveness of treatment and tolerability of the drug. The maximum daily dose is 4 suppositories (2 g). At the same time, you can take salazopyridazine tablets (not exceeding a total daily dose of 3 g) and other drugs for the treatment of ulcerative colitis.
In order to prevent relapses (reappearance of signs of the disease), 1-2 suppositories per day are prescribed for 2-3 months.
The dosage and regimen of the drug for other forms of colitis with ulcerative lesions are the same as for nonspecific ulcerative colitis.

Side effects

When taking salazopyridazine tablets orally, the same adverse reactions are possible as when using sulfonamides and salicylates: allergic phenomena, leukopenia (decrease in the level of leukocytes in the blood), dyspeptic disorders (digestive disorders), sometimes a slight decrease in the level of hemoglobin (the functional structure of the red blood cell that ensures its interaction with oxygen). In such cases, the dose should be reduced or the drug discontinued. After administration of the suspension, a burning sensation in the rectum and the urge to defecate (bowel movement) may appear, especially with rapid administration. When using salazopyridazine in suppositories, there may be a burning sensation and pain in the rectum, and sometimes increased bowel movements. In case of severe pain during rectal administration of salazopyridazine in suppositories, it is recommended to prescribe the drug rectally in the form of a 5% suspension and orally in tablets.

Contraindications

The drug is contraindicated if there is a history (medical history) of toxic-allergic reactions during treatment with sulfonamides and salicylates.

Release form

Tablets of 0.5 g in a package of 50 pieces; 5% suspension in 250 ml bottles (the drug after shaking is an orange suspension, which then settles); candles ( Brown) 0.5 g in a package of 10 pieces.

Storage conditions

List B. In a dark place at room temperature.

Authors

Links

Official instructions for the drug Salazopyridazine.
Modern medications: a complete practical guide. Moscow, 2000. S. A. Kryzhanovsky, M. B. Vititnova.

Attention!
Description of the drug " Salazopyridazine"on this page is a simplified and expanded version official instructions by application. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.