Vacation norms medicines approved by order of the Ministry of Health of the Russian Federation No. 1175. Standards for prescribing and dispensing ethanol (ethyl alcohol, medical antiseptic solution approved by order of the Ministry of Health and Social Development of the Russian Federation dated December 14, 2005 No. 785 “On the procedure for dispensing medicines.”
The rates for prescribing and dispensing drugs may be increased by following cases:
1. The number of prescribed narcotic and psychotropic drugs of lists II and III of the List, other drugs subject to subject-quantitative recording, when providing palliative care to patients medical care can be increased by no more than 2 times compared to the maximum permissible quantity medications to be prescribed per prescription, or the recommended number of medications to be prescribed per prescription.
2. Prescriptions for medications written out on prescription forms Form N 148-1/u-04 (l) and Form N 148-1/u-06 (l) are valid for one month from the date of prescription. Prescriptions for medications written out on prescription forms Form N 148-1/u-04 (l) and Form N 148-1/u-06 (l), for citizens who have reached retirement age, disabled people of the first group and disabled children are valid for three months from the date of issue. For the treatment of chronic diseases, these categories of citizens can be issued prescriptions for medications for a course of treatment of up to 3 months.
3. When a medical worker prescribes prescriptions for finished medicinal products and individually manufactured medicinal products for patients with chronic diseases on prescription forms of form N 107-1/u, it is allowed to set the validity period of the prescription within up to one year and exceed the recommended amount of the medicinal product for prescribing by one recipe. When writing such prescriptions, the medical professional makes a note “Patient with chronic disease", indicates the validity period of the prescription and the frequency of dispensing medications from pharmacy organization or individual entrepreneur licensed for pharmaceutical activities(weekly, monthly and other periods), certifies this instruction with his signature and personal seal, as well as the seal medical organization"For recipes."
4. Prescriptions for barbituric acid derivatives, ephedrine, pseudoephedrine in pure form and in a mixture with other drugs, drugs with anabolic activity, combination drugs containing codeine (its salts) for the treatment of patients with chronic diseases can be prescribed for a course of treatment of up to two months. In these cases, the inscription “By special purpose", separately signed medical worker and the seal of the medical organization "For prescriptions".
5. In accordance with the order of the Ministry of Health and Social Development of the Russian Federation No. 785, the supply of ethyl alcohol is carried out:
According to prescriptions written by doctors with the inscription “For application of compresses” (indicating required dilution with water) or “For leather treatment” - up to 50 grams in pure form;
According to prescriptions written by doctors for individually prepared medicinal prescriptions - up to 50 grams in the mixture;
According to prescriptions written by doctors for individually prepared medicinal prescriptions, with the inscription “For special purposes”, separately certified by the doctor’s signature and the seal of the medical preventive institution"For prescriptions", for patients with chronic course diseases - up to 100 grams in a mixture and in pure form.
- Is it possible to dispense powders according to this recipe No. 30, No. 40?
No. 30 - yes, No. 40 - no, since the dispensing rate for ephedrine hydrochloride is 0.6 g (order No. 1175).
Problem No. 15
The pharmacy received the following drugs: morphine 1% 1.0 No. 5, potassium permanganate pore 3.0, theophedrine N tab.. To which groups from a legal point of view should these drugs be classified? The procedure for filling out a prescription for morphine 1% 1.0 No. 5, the validity period and shelf life of the prescription in the pharmacy. What documents must be used to register received drugs? Requirements for organizing the storage of these drugs. Regulatory justification.
Morphine 1% 1.0 No. 5 - according to PP No. 681, is included in List II of NS and PV, the circulation of which in the Russian Federation is limited and for which control measures are established in accordance with the legislation of the Russian Federation and international treaties of the Russian Federation.
Morphine is prescribed for prescription form Form 107-1/np in accordance with the order of the Ministry of Health of the Russian Federation No. 54 n. Made on paper Pink colour with watermarks. The prescription form must be filled out legibly, clearly, in ink or with a ballpoint pen. Corrections when filling out the prescription form are not allowed. The prescription form is affixed with a stamp from the medical organization (indicating the full name of the medical organization, its address and telephone number) and the date the prescription for the narcotic (psychotropic) was issued. medicinal product.In the lines “Full name of the patient” and “Age” the full last name, first name, patronymic (the latter - if available) of the patient, his age (number of completed years) are indicated. In the line “Series and number of the mandatory policy health insurance" indicates the patient's compulsory medical insurance policy number. In the line "Number medical card outpatient (history of child development)" indicates the number of the outpatient medical card (history of child development). In the line "F.I.O. doctor (paramedic, midwife)" indicates the full last name, first name, patronymic (the latter - if available) of the doctor (paramedic, midwife) who wrote the prescription for a narcotic (psychotropic) drug. In the line "Rp:" on Latin the name of the narcotic (psychotropic) drug (international non-proprietary or chemical, or in their absence - trade name), its dosage, quantity and method of administration is indicated. One name of the narcotic (psychotropic) drug is written on one prescription form. The quantity of a narcotic (psychotropic) drug prescribed on a prescription form is indicated in words. The method of taking a narcotic (psychotropic) drug is indicated in Russian or national languages. When indicating the method of taking a narcotic (psychotropic) drug, it is prohibited to limit oneself to general instructions, such as “Internal”, “Known”. A prescription for a narcotic (psychotropic) drug is certified by the signature and personal seal of the doctor, the signature of the manager (deputy manager or manager structural unit) medical organization (indicating his last name, first name, patronymic (the latter - if available)), as well as the round seal of the medical organization, the imprint of which must identify the full name of the medical organization. In the line “Pharmacy organization’s mark on dispensing”, a mark from the pharmacy organization on the dispensing of the narcotic (psychotropic) drug is placed (indicating the name, quantity of the narcotic (psychotropic) drug dispensed and the date of its dispensing). of the drug is certified by the signature of the employee of the pharmacy organization who dispensed the narcotic (psychotropic) drug (indicating his last name, first name, patronymic (the latter - if available)), as well as the round seal of the pharmacy organization, the imprint of which must identify the full name of the pharmacy organization. The validity of the prescription is 5 days, the shelf life in the pharmacy is 10 years.
Rules for storing NS and PV approved by the Russian Federation GD dated December 31, 2009 No. 1148. Storage of NS and PV is carried out by legal entities that have a license for activities related to the circulation of NS and PV, as well as the right to store them (hereinafter referred to as legal entities). Storage of NS and PV is carried out in isolated premises, specially equipped with engineering and technical means security (hereinafter referred to as premises), and in places of temporary storage. Premises are divided into 4 categories . For premises of each category, basic requirements are established for their equipment with engineering and technical security equipment, as well as for the conditions for storing narcotic drugs and psychotropic substances in them. Category 2 includes premises of pharmaceutical establishments , intended for storing a month's supply of NS and PV used for medical purposes. The premises belonging to the 2nd category are equipped with security alarm systems consisting of at least 2 lines of protection and an alarm system with signals output to the central monitoring console of the police department private security at the internal affairs body Russian Federation, and if such a connection is not possible - with a signal output to the security post. Entrance door the room can be made of metal, wood (reinforced with upholstery on 2 sides with sheet iron or metal plates) or from another material that provides a protection class from destructive influences of at least 3. The entrance door has at least 2 locking devices of the 3rd class of protection against destructive influences. The doorway of the entrance to the room is protected with inside an additional metal lattice door with a locking device, having a protection class from destructive influences of at least 2, made of steel reinforcement. On the window structures of the 1st and last floors, metal gratings made of steel rods are installed on the inside or between the frames, or blinds equivalent in strength to metal grilles. Window structures must have a protection class from destructive influences of at least 3. Narcotic drugs and psychotropic substances are stored in locked safes of at least class 4 burglary resistance or metal cabinets. In the premises related to 4th category , narcotic drugs and psychotropic substances are stored in locked bulk or attached to the floor (wall) safes of at least class 3 burglary resistance. A safe weighing less than 1000 kilograms is attached to the floor or wall or built into the wall using an anchor. In other places of temporary storage, narcotic drugs and psychotropic substances are stored in locked safes of at least class 1 burglary resistance or metal or containers made of other high-strength materials.
In accordance with the order of the Ministry of Health and Social Development of the Russian Federation No. 397 n “On approval of special storage conditions for NS and PV, registered in the prescribed manner in the Russian Federation as drugs intended for medical use, in pharmacies, medical institutions, research and educational organizations and drug wholesale trade organizations" storage pharmaceutical substances narcotic and psychotropic drugs in pharmacies should be carried out in bars indicating the highest single and highest daily doses. Storage of narcotic and psychotropic medications used during the working day in assistant rooms and prescription departments of pharmacies, in classrooms of educational organizations, as well as in laboratories of research organizations is carried out in safes (containers) of these premises or departments. At the end of the working day, narcotic and psychotropic medicines must be returned to the place of main storage of narcotic and psychotropic medicines. It is allowed to store narcotic and psychotropic medicines that require protection from elevated temperature, in pharmacies, medical and preventive institutions, research, educational organizations and wholesale trade organizations of medicines: in premises of the 1st and 2nd categories, specially equipped with engineering and technical security means - in locked refrigerators (refrigerators) or in a special area for placing refrigerators (refrigeration chambers), separated from the main storage area by a metal grill with a lockable lattice door, in rooms of the 4th category - in thermal containers located in safes; in places of temporary storage - in thermal containers placed in safes, or in metal or other high-strength materials containers placed in thermal containers.
The order of the head of the legal entity appoints persons responsible for the storage of NS and PV, authorized to work with NS and PV, and establishes the procedure for storing keys to safes, metal cabinets and premises, as well as those used for sealing (sealing) seals and sealing devices. List of persons, having the right to access the premises, is approved by order of the head of the legal entity.
in accordance with the requirements of the order of the Ministry of Health and Social Development of the Russian Federation dated August 23, 2010 No. 706n “On approval of the rules for storing medicines.” Medicines subject to subject-quantitative accounting are stored in metal or wooden cabinets, sealed or sealed at the end of the working day.
Problem No. 16
The pharmacy of a medical organization received an application from surgical department for a solution of magnesium sulfate for injection 25% - 10.0 in ampoules and a solution of promedol for injection 1% - 1.0 in ampoules.
- to which groups do these drugs belong from a regulatory perspective?
- on the basis of what documents does the pharmacy dispense such drugs to the departments?
What is the procedure for filling out invoice requirements for receiving these drugs by departments of a medical organization?
- Name the shelf life of the invoice requirements for these medications in the pharmacy of the medical organization.
- which of the Moscow Region personnel has the right to receive promedol injection solution 1% - 1.0?
How is the permission for an organization to work with promedol injection solution 1% - 1.0 documented and how is personnel allowed to work with this drug?
From a regulatory and legal position: magnesium sulfate solution belongs to other drugs dispensed by prescription; promedol for injection - NS list II in accordance with RF RF No. 681;
In accordance with Order of the Ministry of Health and Social Development of the Russian Federation No. 110, to ensure the diagnostic and treatment process, medical organizations receive medications from a pharmacy organization according to invoice requirements approved in the prescribed manner. The demand invoice for receiving medicines from pharmacy organizations must have a stamp, a round seal of the medical organization, and the signature of its head or his deputy for medical treatment. The demand invoice indicates the number, date of preparation of the document, sender and recipient of the medicinal product, name of the medicinal product (indicating the dosage, release form (tablets, ampoules, ointments, suppositories, etc.), type of packaging (boxes, bottles, tubes etc.), method of application (for injection, for external use, oral administration, eye drops, etc.), the number of drugs requested, the quantity and cost of drugs dispensed. The names of drugs are written in Latin. Requirements - invoices for medicines subject to subject-quantitative accounting are issued on separate forms of invoice requirements for each group of drugs. Requirements-invoices of a structural unit of a medical organization (office, department, etc.) for medicines sent to a pharmacy organization, are drawn up in the prescribed manner, signed by the head of the relevant department and issued with the stamp of the medical organization. When prescribing a medicinal product for an individual patient, his surname and initials and medical history number are additionally indicated. Requirements for poisonous medicines, in addition to the signature of the dentist or dentist, must have the signature of the head of the institution (department) or his deputy and the round seal of the medical organization.
In pharmacy organizations, the invoice requirements of medical institutions for the dispensing of narcotic drugs and psychotropic substances of lists II and III are stored for 10 years, for the dispensing of other drugs subject to subject-quantitative accounting - for 3 years, for other groups of drugs drugs - within one calendar year. Requests-invoices of medical organizations must be stored in a pharmacy organization in conditions that ensure safety, bound and sealed and drawn up in volumes indicating the month and year. After the expiration of the storage period, the invoice requirements are subject to destruction in the presence of members of the commission created in the pharmacy organization, about which acts of the approved form are drawn up.
The release of NS and PV to the Moscow Region is carried out by employees of the Moscow Region, the list of whom is approved by order of the Ministry of Health and Social Development of the Russian Federation No. 330, these include: heads. doctor, head of department, deputy head of department, senior medical officer. sister. The admission of persons to work with NS and DP, precursors included in Table 1 of List IV is determined by RF PP No. 892 “On approval of the rules for the admission of persons to work with NS and DP, as well as to activities related to the circulation of NS and DP precursors.” Admission is carried out by the head of the organization and includes:
1. familiarization of persons with the legislation of the Russian Federation on NS and PV;
2. issuance of an order on the admission of persons to work with NS and DS, as well as activities related to the circulation of NS and DS precursors.
3. conclusion of a TD including mutual obligations of the organization and person related to the circulation of NS and DS and their precursors. Not allowed to work:
Under 18 years of age;
Those who have an outstanding or unexpunged conviction for crimes of moderate gravity, serious and especially serious crimes;
Those who have an outstanding or unexpunged conviction for crimes related to illegal trafficking NS and PV and their precursors;
Patients with drug addiction, substance abuse, and hron. alcoholism;
Recognized in accordance with the established procedure as unsuitable for performing work related to the circulation of NS and PV.
In order to obtain information about persons registered to work with NS and PV, the head of the organization:
1. gives the person a referral to the Moscow Region for medical treatment. examination and mandatory psychiatric examination (for NS and PV).
2. sends an application to the FSKN authorities with the attachment of employee questionnaires to obtain a conclusion that the employees have no outstanding or unexpunged convictions for crimes of moderate gravity, serious and especially serious crimes, for crimes related to the illicit trafficking of NS and DS and their precursors.
If there are no grounds preventing a person from being allowed to work with NS and PV, the manager issues an appropriate order and concludes a TD. The validity period of a person’s permission to work with NS and PV is limited to the validity period of the TD.
Problem No. 17.
The Moscow Region pharmacy received a request from the surgical department for a solution of promedol 1% 1.0 in ampoules.
- Which group of drugs does promedol solution belong to from a legal perspective?
What is the procedure for processing invoice requirements for departments of a medical organization to receive this drug?
- which of the Ministry of Defense personnel has the right to receive such drugs?
- who is responsible for monitoring the storage and use of such drugs in the departments of the Ministry of Defense?
- features of drug data accounting, reporting.
Promedol belongs to the NS and PV of List II according to the RF Regulation No. 681. From the staff of health care facilities, the right to receive NS and PV is assigned to executive(approved to work with NS and PV), authorized to do so by order of the head of the healthcare facility (head physician, head of department, deputy head of department, head nurse) in accordance with order No. 330.
Control over the storage of NS and PV in the divisions of health care facilities is assigned to an official authorized to do this by order of the head of the health care facility (head of department). By order of the head of the health care facility, persons responsible for the storage of NS and PV are appointed, authorized to work with NS and PV, and the procedure is established storage of keys to safes, metal cabinets and premises, as well as seals and sealing devices used for sealing. The list of persons who have the right to access the premises is approved by order of the head of the health care facility (Government of the Russian Federation dated December 31, 2009 No. 1148 “On the procedure for storing NS and PV.”
Order 397n – On approval of special requirements for storage conditions of NS and PV, registered in the prescribed manner in the Russian Federation as drugs intended for medical care in pharmacies, health care facilities, research institutions, account. Organizations, drug wholesale trade organizations.
Promedol 1% 1,0 – is subject to PKU as NS List II in the “Logbook of registration of transactions related to the turnover of NS and PV”.
The rules for maintaining and storing, as well as the forms of special logs for registering transactions related to the trafficking of narcotic drugs and psychotropic substances, were approved by Decree of the Government of the Russian Federation dated November 4, 2006 No. 644 “On the procedure for submitting information on activities related to the trafficking of narcotic drugs and psychotropic substances, and registration of transactions related to the trafficking of narcotic drugs and psychotropic substances” (as amended).
In quantitative terms, Schedule II narcotic drugs, Schedule II and III psychotropic substances are taken into account in a special “Logbook of registration of transactions related to the trafficking of narcotic drugs and psychotropic substances” .
Legal entities, as well as their divisions carrying out activities related to the circulation of narcotic drugs, psychotropic substances and their precursors, are required to maintain registration logs in the form approved by Decree of the Government of the Russian Federation of November 4, 2006 No. 644 (as amended).
Registration of transactions related to the circulation of narcotic drugs and psychotropic substances is carried out for each name of narcotic drug and psychotropic substance on a separate, expanded sheet of the registration log or in a separate registration log.
Any operations that result in changes in the quantity and condition of narcotic drugs and psychotropic substances must be entered in the registration log. In pharmacies, these will be operations for the receipt and consumption of narcotic drugs and psychotropic substances, either in the form of substances or in the form of industrially manufactured drugs. In this case, the units of measurement will be different (grams, bottles, ampoules, patches, tablets, etc.). Log books must be bound, numbered and signed by the manager legal entity and the seal of a legal entity. If necessary, by decision of the authority executive power of the constituent entity of the Russian Federation is determined by the body that certifies the “Logbook of registration of transactions related to the circulation of narcotic drugs and psychotropic substances.”
The head of a legal entity appoints persons responsible for maintaining and storing registration logs, including in departments.
Entries in the log books are made by the person responsible for their maintenance and storage, using a ballpoint pen (ink) in chronological order immediately after each operation for each name of a narcotic drug or psychotropic substance on the basis of documents confirming the completion of this operation. Documents or copies thereof confirming the completion of a transaction with a narcotic drug or psychotropic substance, certified in the prescribed manner, are filed in a separate folder, which is stored together with the corresponding registration log.
The registration logs indicate the names of narcotic drugs and psychotropic substances in accordance with the List of narcotic drugs, psychotropic substances and their precursors approved. by Decree of the Government of the Russian Federation of June 30, 1998 No. 681 (as amended), and other names of narcotic drugs and psychotropic substances under which they were received by a legal entity. Lists of names of narcotic drugs and psychotropic substances registered as medicines (international generic, patented, original titles or in their absence, chemical names) are entered by the Federal Service for Surveillance in Healthcare and social development to the state register of medicines.
The numbering of entries in the registration logs for each name of a narcotic drug or psychotropic substance is carried out within a calendar year in ascending order of numbers. The numbering of entries in new log books begins with the number following last number in completed journals. Pages of the registration logs that are not used in the current calendar year are crossed out and are not used in the next calendar year.
An entry in the log books of each transaction performed is certified by the signature of the person responsible for their maintenance and storage, indicating the surname and initials.
Corrections in the registration logs are certified by the signature of the person responsible for their maintenance and storage. Erasures and uncertified corrections in log books are not permitted.
Legal entities carry out a monthly inventory of narcotic drugs and psychotropic substances in accordance with the established procedure by comparing their actual availability with accounting data (book balances). The registration logs must reflect the results of the inventory of narcotic drugs and psychotropic substances.
Inventory of narcotic drugs and psychotropic substances is carried out in accordance with the requirements of Article 38 Federal Law dated 01/08/1998 No. 3-FZ “On narcotic drugs and psychotropic substances”, order of the Ministry of Finance of Russia dated 06/13/1995 No. 49 “On approval methodological instructions on inventory of property and financial obligations", Resolution of the State Statistics Committee of Russia dated 08/18/1998 No. 88 "On approval of unified forms of primary accounting documentation for recording cash transactions, recording inventory results" and order of the USSR Ministry of Health dated 01/08/1988 No. 14 "On approval specialized (intradepartmental) forms of primary accounting for self-supporting pharmacies”, with the creation of an inventory commission, with the preparation of descriptive inventory sheets. In the journal for registering transactions related to the circulation of narcotic drugs and psychotropic substances, a note is made about the inventory carried out (date of inventory, number of the matching sheet or inventory list).
According to Article 38 of the Federal Law of 01/08/1998 No. 3-FZ “On Narcotic Drugs and Psychotropic Substances”, information about discrepancies in the balance or discrepancy between the balance data and the results of the inventory carried out in three-day period after their detection, they are brought to the attention of the authorities for control over the circulation of narcotic drugs and psychotropic substances.
Discrepancies or inconsistencies in the results of reconciliation of precursors are brought to the attention of the relevant territorial authority Federal service of the Russian Federation for drug control during 10 days from the moment they are identified.
The register of narcotic drugs and psychotropic substances is stored in a metal cabinet (safe) in a technically fortified room. The keys to the metal cabinet (safe) and the technically fortified room are kept by the person responsible for maintaining and storing the registration log.
Completed registration logs, together with documents confirming the implementation of transactions related to the circulation of narcotic drugs and psychotropic substances, are handed over to the archives of a legal entity, where they are stored for 10 years after the last entry is made in them. After the specified period, the registration logs are subject to destruction according to an act approved by the head of the legal entity.
The rules for submitting reports to legal entities on activities related to the circulation of NS and PE were approved by the RF PP dated 04.11.06 No. 644 as amended by LE - holders of licenses to carry out activities related to the circulation of NS and PE are required to report on the quantity of each produced, manufactured, imported (exported), released and sold NS and PV, as well as their stocks as of December 31 of the reporting year.
Pharmacies and having pharmacies, health care facilities that carry out, in the prescribed manner, the manufacture of medicines containing NS and PIs, the dispensing and sale of NS and PIs, submit annually, no later than February 15, to the relevant territorial bodies of the Federal Service of the Russian Federation for Drug Control in the form according to the Appendix N 6:
· annual report on the number of manufactured, released and sold NS and PV;
The quantity and reserves of NS and PV are indicated in the reports in terms of current NS and PV.
Prescribing medications and processing prescriptions and invoice requirements approved by order 1175.
Problem No. 18
The pharmacy received a prescription for the preparation of a mixture of the following composition:
Rp.: Infusi rhizomatis cum radicibus Valerianae ex.................... 10.0
Ephedrine hydrochloride and other salts
Appendix No. 9
Rules for dispensing codeine-containing drugs:
1. Prescription form f-148-1/u-88.
2. Availability of a stamp, the doctor’s personal seal and the “For prescriptions” seal.
3. The validity period of the prescription is 10 days.
4. If the prescription is filled out correctly, tax it and sign the vacation on the back of the prescription.
5. A selection of recipes and recording in the journal is carried out by the manager daily, the results are summed up monthly and annually. The use of a proofreader is not permitted in the journal. If there is an error, the incorrect number is crossed out, the correct one is written, and certified by three signatures.
| № | Medications | Codeine content in 1 package | Dispensing rate per 1 prescription |
| 1. | Codelac No. 10 | 0,08 | 2 pack |
| 2. | Codelac phytoelixir 100ml | 0,09 | 2 fl |
| 3. | Kaffetin No. 12 | 0,12 | 1 pack |
| 4. | No-shpalgin No. 12 | 0,096 | 2 pack |
| 5. | Nurofen plus No. 12 | 0,153 | 1 pack |
| 6. | PentalginICN No. 12 | 0,096 | 2 pack |
| 7. | PentalginH No. 10 | 0,08 | 2 pack |
| 8. | Pentalgin plus No. 12 | 0,096 | 2 pack |
| 9. | Piralgin No. 10 | 0,08 | 2 pack |
| 10. | Piralgin No. 20 | 0,16 | 1 pack |
| 11. | Sedal M No. 10 | 0,1 | 2 pack |
| 12. | Sedal M No. 20 | 0,2 | 1 pack |
| 13. | Sedalginneo No. 10 | 0,1 | 2 pack |
| 14. | Sedalginneo No. 20 | 0,2 | 1 pack |
| 15. | Solpadeincaps. No. 12 | 0,096 | 2 pack |
| 16. | Solpadeine tab. No. 12 | 0,096 | 2 pack |
| 17. | Solpadeine tab. No. 8 | 0,064 | 3 pack |
| 18. | Solpadeintab.sol. No. 12 | 0,096 | 2 pack |
| 19. | Terpin code No. 10 | 0,08 | 2 pack |
| 20. | Tetralgin No. 10 | 0,08 | 2 pack |
| 21. | Unispaz No. 12 | 0,096 | 2 pack |
Appendix No. 10
Rules for preparing prescriptions /Orders of the Ministry of Health of the Russian Federation No. 1175, 54, 785/
| № | Medications | Form f - | Validity | Shelf life | |
| 1. | - Narcotic drugs and psychotropic substances of list II (3-FZ, RF PP No. 681 - buprenorphine, morphine g / chl, omnopon, promedol, prosidol, fentanyl / transdermal system, TB sublingual / | A special form with a serial number and degree of protection F - 107/u-NP | It is written out by a doctor, the series and number are indicated compulsory medical insurance policy, signed ch. doctor or deputy according to treatment work, certified by the round seal of the Moscow Region, one name is written out, the quantity of the drug is indicated in words, the quantity of the drug is prescribed in accordance with the norms for one-time dispensing according to one prescription | 5 days | 10 years In the line “Pharmacy organization’s mark on dispensing” the mark apt. org. on the dispensing of the medicinal product (indicating the name, quantity of the dispensed medicinal product and the date of its dispensing) and is certified by the signature of the pharmacist and the round seal of the pharmacy. |
| 2. | - Psychotropic substances of list III (3-FZ, RF PP No. 681, 427, 486, 78 - butorphanol, tianeptine, diazepam, nitrazepam, oxazepam, phenobarbital, etc.) | F - 148-1/u-88 | Certified by the seal of the Ministry of Defense “For prescriptions”, one name is written out, the quantity of the drug is prescribed in accordance with the standards for one-time dispensing per one prescription | 10 days | 10 years |
| 3. | - Other medications subject to PCU - anabolic hormones - drugs (clause 5 of pr. No. 562n - codeine-containing drugs - see Appendix No. 9) | F - 148-1/u-88 | Certified by the seal of the Ministry of Defense “For prescriptions”, one name is written out, the quantity of the drug is prescribed in accordance with the standards for one-time dispensing for one prescription | 10 days | 3 years |
| 4. | - The remaining drugs are drugs (clause 4, pr. No. 562n) | F - 107-1/u | In gr. Rp is indicated by INN or grouping, or tradename Medicines in Latin (uniform requirement for all forms), no more than three medicines are issued | 2 months | Doesn't stay in the pharmacy |
| 5. | Sick with a chronic course of the disease for a course of treatment of up to 2 months: - Derivatives of barbituric acid - Pseudoephedrine and ephedrine in pure form and in mixtures - Anabolics - Combined drugs, soda codeine and its salts | F - 148-1/u-88 | Additional inscription in the upper right corner “for special purposes”, certified by the signature of the attending physician and the seal of the Ministry of Defense “For prescriptions” | 10 days | 3 years |
| № | Medications | Form f- | Recipe design features | Validity | Shelf life |
| 6. | For patients with chronic illness, the prescription is valid for up to one year | F - 107-1/u | An additional inscription in the upper right corner “For a patient with a chronic disease” indicating the validity period and frequency of dispensing of the drug (monthly, weekly, etc.), certified by the doctor’s signature, his personal seal and the seal of the Ministry of Defense “For Prescriptions” | Up to 1 year | Upon expiration, it is canceled with the stamp “The prescription is not valid”, remains in the pharmacy, the shelf life is not established |
| 7. | - Tranquilizers not subject to PCU; - neuroleptics; - antidepressants; - alcohol-containing medicinal products of factory production - LP (clause 4 of order No. 562n) | F - 107-1/u | - | 2 months | The prescription is canceled with the “Medicine Dispensed” stamp; for re-dispensing you need new recipe |
| 8. | - Medicines sold free of charge or at a discount | F - 148-1/u-04(l), 06(l) | It is written out in 3 copies, having a single series and number, indicating the patient’s full last name, first name, patronymic, date of birth, SNILS, compulsory medical insurance policy number, address or medical number. patient cards (history of the child’s development), the INN or grouping or trade name of the drug in Latin is indicated, registration of all details using computer technology is allowed. | 5 days - for NPs, 10 days - PKU, 1 month, 3 months - for disabled people of group 1, disabled children, citizens who have reached retirement age | 5 years |
| Number of prescribed narcotic and psychotropic drugs medicinal products of lists II and III of the List, other medicinal products drugs subject to subject-quantitative accounting, when providing palliative care to patients can be increased by no more than 2 times compared to the maximum permissible quantity of drugs for prescribing per prescription, installed by application No. 1 to Order No. 1175, or the recommended quantity of medications for prescribing per prescription, installed by application No. 2 to order No. 1175. |
Appendix No. 11
Approved
Government Decree
Russian Federation
/ Pentalgin-N
Pentalgin-N Pentalgin-N
Drops in pharmacies
over the counter
Manufacturer
Pharmstandard-Leksredstva, Russia
Pharmacological group
Analgesic
Active substance
metamizole sodium, codeine, phenobarbital, caffeine, naproxen ( combination drug)
"Pentalgin-N" - effective drug, which has a strong analgesic and anti-inflammatory effect. Relieves pain of various etiologies. Particularly effective when severe pain, including postoperative. Dispensed from pharmacies by prescription, taken only according to indications; to prescribe, you must contact your doctor.
Application of Tempalgin
Tempalgin is a combined analgesic (painkiller) drug with antipyretic and sedative effects. It is used for feverish conditions due to high temperature body, for toothache and headache, reducing pain after surgical interventions. When using Tempalgin, fear, anxiety, agitation go away and decrease arterial pressure. Tempalgin is a fast-acting drug that has a sedative effect within half an hour, and an analgesic effect after an hour. It cannot be used as a course, but should be immediately canceled as soon as the opportunity arises.
Tempalgin for headaches and toothaches
Each person has his own threshold for pain sensitivity and sometimes it is simply impossible to endure pain, especially dental and headache pain. Tempalgin will help relieve moderate pain and dull acute pain. toothache. It contains analgesic and sedative substances, so the pain will go away within 10-15 minutes after taking the tablet, and the analgesic effect will last for several hours. The tablet should be taken after meals with plenty of water. Dosage for adults – 1-2 tablets three times a day (no more than 6 tablets per day). Children over 14 years of age can be given 1 tablet twice a day. Tempalgin should not be used for more than 5 days!
Composition of tablets of the drug "Pentalgin-N" and release form
Pentalgin-N is available in the form of tablets, white or white with a yellowish or creamy tint, flat-cylindrical, with the abbreviated name of the drug PENT-N embossed on one side. One tablet contains:
- metamizole sodium 300 mg,
- caffeine 50 mg,
- naproxen 100 mg,
- codeine 8 mg,
- phenobarbital 10 mg,
- auxiliary components.
Pentalgin-N tablets You can buy 10 pieces in a blister pack. 1 or 2 blister packs along with instructions for use in a cardboard pack.
pharmachologic effect
Pentalgin-N is a combination drug that has analgesic, anti-inflammatory and antipyretic effects. Naproxen and metamizole sodium have analgesic and anti-inflammatory effects. Codeine stimulates opioid receptors in various parts of the central nervous system, which leads to activation of the antinociceptive system and a change in the emotional perception of pain. Codeine and phenobarbital increase the analgesic effect of metamizole sodium and naproxen. Caffeine dilates blood vessels skeletal muscles, kidneys, heart, brain.
Pentalgin-N increases mental and physical performance, eliminates fatigue and drowsiness; increases the permeability of histohematic barriers and increases the bioavailability of non-opioid analgesics, thereby promoting increased therapeutic effect. The drug is biotransformed in the liver, excreted by the kidneys, and penetrates the placental barrier.
Indications for use
Pentalgin-N tablets are indicated for use in mild to moderate pain syndrome of various origins, including pain in the joints, muscles, radiculitis, menstrual pain, neuralgia, dental pain and headaches (including migraines). They also help with post-traumatic and postoperative pain syndrome.
Contraindications
Pentalgin-N is contraindicated for use in the following cases:
- Hypersensitivity to the components of the drug
- Portal hypertension, severe arterial hypertension
- Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), gastrointestinal bleeding
- Bronchial asthma, bronchospasm
- Alcohol intoxication
- Glaucoma
- Liver and kidney dysfunction
- Heavy organic diseases cardiovascular system (including acute heart attack myocardium), arrhythmia
- Traumatic brain injury
- Anemia, leukopenia
- Glucose-6-phosphate dehydrogenase deficiency
- Children's age up to 12 years
- Pregnancy, lactation period
Take with caution when arterial hypertension mild to moderate severity, in old age. A doctor's consultation is required.
Application of Pentalgin N during pregnancy and breastfeeding: the drug is contraindicated during pregnancy and lactation; it passes into breast milk.
Instructions for use
Pentalgin-N is taken orally. The drug is taken 1 tablet 1-3 times a day. The maximum daily dose is 4 tablets. It is not recommended to use the drug for more than five days as an analgesic and for more than three days as an antipyretic without a doctor’s prescription and supervision.
Side effects
Allergic reactions, including Steven-Johnson syndrome, Lyell's syndrome; bronchospasm.
Causes addiction and drug dependence when taken for a long time.
Overdose
Symptoms of drug overdose: nausea, vomiting, gastralgia, drowsiness, tachycardia, cardiac arrhythmias, respiratory depression, delirium, weakness.
Treatment for overdose: induction of vomiting, gastric lavage through a tube, administration of adsorbents (activated carbon), symptomatic therapy aimed at maintaining vital functions.
Interaction with other drugs
Concomitant use of Pentalgin N with other non-opioid analgesics may lead to increased toxic effects. Sedatives and tranquilizers enhance the analgesic effect of the drug. The simultaneous use of metamizole with cyclosporine reduces the level of the latter in the blood. Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effects of metamizole sodium. Tricyclic antidepressants, oral contraceptives, and allopurinol increase the toxicity of metamizole sodium, which is included in the drug.
special instructions
During treatment you should avoid drinking alcohol. With long-term use (more than 5 days), it is necessary to monitor the peripheral blood picture and liver function indicators. The use of the drug may change the results of doping control of athletes.
In some cases, a decrease in concentration and speed of psychomotor reactions is possible, therefore, during the treatment period, care must be taken when driving vehicles and engaging in other potentially dangerous activities. dangerous species activities that require increased concentration and speed of psychomotor reactions. Taking the drug may make it difficult to establish a diagnosis for acute abdominal pain syndrome.
Release from pharmacies
Pentalgin-N is released strictly according to prescription. Form 148-1/у-88. There is a dispensing norm for 1 prescription, taking into account an indivisible package of 20 tablets.
Storage conditions
In a dry place, at a temperature not exceeding 25 C. Keep out of the reach of children! Do not use the drug after the expiration date indicated on the package.
Analogues of Pentalgin-N
You can replace Pentalgin-N with the following analogue drugs:
- "Piralgin" (Belarus) - tablets No. 10.
Narcotic drugs: Buprenorphine, Codeine, Codeine phosphate, Cocaine, Cocaine hydrochloride (hydrochloride), Morphine, Morphine hydrochloride, Morphine sulfate, Morphilong, Omnopon, Prosidol, Promedol, Fentanyl, Estocin, Estocina hydrochloride, Ethylmorphine hydrochloride, etc. .
Psychotropic substances: Amobarbital (Barbamil), Amfepramone (Fepranone), Ketamine, Ketamine hydrochloride (Calipsol, Ketalar), Etaminal sodium, etc.
Rules for prescribing narcotic drugs and psychotropic substances:
The drug is prescribed on a special pink prescription form.
The amount of narcotic drugs and psychotropic substances prescribed in a prescription is indicated in words.
In the column “Medical history No...” the medical No. is indicated. outpatient cards.
The prescription is signed by the doctor and certified with his personal seal. Additionally, the prescription is signed by the head physician of the medical and preventive institution or deputy and certified with the round seal of the health care facility.
Narcotic drugs and psychotropic substances included in list 2 of the list of “Narcotic drugs, psychotropic substances and their precursors subject to control in the Russian Federation” are prescribed on the prescription form.
Only one name of the drug is written on one prescription form.
answer21. Rules for writing prescriptions: list of drugs and substances prescribed on form No. 148, design of the form.
List of funds subject to PCU:
1. Narcotic drugs and psychotropic substances of Schedule 2 (see question No. 20), psychotropic substances Schedule 3: Aprofen, Halothane (Ftorotan), Sodium hydroxybutyrate and other salts of hydroxybutyric acid, Taren, Pentobarbital, Ethylamphetamine, etc.
2. Schedule 4 precursors: Acetone, Potassium permanganate, Pseudoephidrine, Sulfuric acid, Hydrochloric acid, Ephedrine, Ergometrine, Ergotamine, Ethyl ether, etc.
3. Strongly active ingredients List No. 1 of the PCCN (Permanent Committee on Narcotics Control): Barbital, Clonidine, Diazepam, Spasmoveralgin, Ether for anesthesia, etc.
4. Poisonous substances Sp. No. 2 PKKN: Arsenic anhydride, Mercury dichloride, Strychnine nitrate, etc.
5. Substances: appomorphine h/x, homatropine hydrobromide, atropine sulfate, dicaine, silver nitrate, pachycarpine hydroiodide.
6. Ethyl alcohol.
7. Medical antiseptic solution.
8. Clozapine (Leponex, Azaleptin).
9. Butorphanol (Stadol, Moradol).
Form No. 148-1/u-88.
The prescription is signed by the doctor and certified with his personal seal. Additionally, it is certified by the seal of the health care facility “For prescriptions.”
List 3 psychotropic substances are prescribed on the prescription form; other medicines subject to PCU; anabolic steroids.
Only one name of the drug is allowed to be written on one form.
22. Rules for writing prescriptions: filling out form No. 107.
23. Rules for writing prescriptions: standards for dispensing narcotic and other substances, conditions for overestimation.
1. Codeine, codeine phosphate 0.2
2. Morphine hydrochloride. Solution for injection, ampoules 1% 1 ml, 20 ampoules.
3. Omnopon. Solution for injection, ampoules 1%, 1 ml, 10 ampoules, 2%, 1 ml, 5 ampoules.
4. Promedol. Tablets for oral administration, 25 mg, 50 tablets.
5. Promedol. Solution for injection, ampoules 1-2%, 1 ml, 10 ampoules. Syringe tube 1-2% 1 ml 10 syringe tubes.
6. Ethylmorphine hydrochloride and other ephedrine salts (powder) 0.6 g.
7. Ethylmorphine hydrochloride (dionine) powder 0.2 g.
8. Combined drugs containing Ephedrine hydrochloride, included in list No. 1 of potent substances of PKKN:
1) Teofedrine, Teofedrin-N, Neo-theofedrine 30 tablets
2) Solutan 1 bottle
3) Spasmoveralgin, Spasmoveralgin-Neo 50 tablets
9. Clonidine 0.075 mg 0.15 mg 1 package, 50 tablets
10. Pachycarpine hydroiodide (powder) 1.2g
11. Anabolic hormones: neurobolil 1 pack, methandrostenolol 5 mg No. 10, oxandrolone 25 mg No. 100, retabolil 50 mg 1 ml No. 1, Nandrolone 1 ml No. 6 and No. 12, Silabolin 2.5% 1 ml No. 10
12. Derivatives of barbituric acid: phenobarbital 50 mg 10 tabs, phenobarbital 100 mg 12 tabs,
13. Fepranon 25 mg 50 tab
14. Ethyl alcohol: pure 50.0 and mixed 50.0
1. Ethylmorphine hydrochloride (dionine). Possible in eye drops and ointments up to 1.0, and for overestimation you need a doctor’s order “for a special purpose”, which is certified by the signature and personal seal of the doctor and the seal of the health care facility “for prescriptions”
2. Narcotic drugs, barbituric acid derivatives and potent drugs can be increased 2 times compared to what is indicated in the table for incurable cancer patients. There must be a written order from the head of the health care facility to assign the patient to the pharmacy to provide him with narcotic drugs.
3. Derivatives of barbituric acid, ephedrine, pseudoephedrine can be prescribed for a course of treatment of up to 1 month. The prescription must contain: a doctor’s instruction “for a special purpose,” which is certified by the doctor’s signature and the seal of the health care facility “for prescriptions.”
4. Ethyl alcohol for patients with chronic illness up to 100.0 in a mixture and in pure form. On the prescription: a doctor’s instruction “for a special purpose,” certified by the doctor’s signature and stamp “for prescriptions.”
answer22. Rules for writing prescriptions: filling out form No. 107 .
1. To be filled out by the doctor in legible handwriting. 2. The name and age of the patient are indicated. 3. In column Rp: dosage and name of the drug. 4. The doctor’s personal signature and stamp is affixed. 5. All drugs are prescribed except for narcotic, psychotropic, sp.2, potent and poisonous ones. 6.No more than 3 drugs are written on one form. 7. On the back there are 3 columns: prepared, checked, released. 8. A health care facility stamp is affixed to the top of the prescription. 9. Corrections are not allowed. 10. Valid for 1 month, stored in the pharmacy for 1 year.
answer23. Rules for writing prescriptions: standards for dispensing narcotic and other substances, conditions for overestimation .
Norms for dispensing narcotic and other substances:
15. Codeine, codeine phosphate 0.2
16. Morphine hydrochloride. Solution for injection, ampoules 1% 1 ml, 20 ampoules.
17. Omnopon. Solution for injection, ampoules 1%, 1 ml, 10 ampoules, 2%, 1 ml, 5 ampoules.
18. Promedol. Tablets for oral administration, 25 mg, 50 tablets.
19. Promedol. Solution for injection, ampoules 1-2%, 1 ml, 10 ampoules. Syringe tube 1-2% 1 ml 10 syringe tubes.
20. Ethylmorphine hydrochloride and other ephedrine salts (powder) 0.6 g.
21. Ethylmorphine hydrochloride (dionine) powder 0.2 g.
22. Combined drugs containing Ephedrine hydrochloride, included in list No. 1 of potent substances of PKKN:
4) Teofedrine, Teofedrin-N, Neo-theofedrine 30 tablets
5) Solutan 1 bottle
6) Spasmoveralgin, Spasmoveralgin-Neo 50 tablets
23. Clonidine 0.075 mg 0.15 mg 1 package, 50 tablets
24. Pachycarpine hydroiodide (powder) 1.2g
25. Anabolic hormones: neurobolil 1 pack, methandrostenolol 5 mg No. 10, oxandrolone 25 mg No. 100, retabolil 50 mg 1 ml No. 1, Nandrolone 1 ml No. 6 and No. 12, Silabolin 2.5% 1 ml No. 10
26. Derivatives of barbituric acid: phenobarbital 50 mg 10 tabs, phenobarbital 100 mg 12 tabs,
27. Fepranon 25 mg 50 tab
28. Ethyl alcohol: pure 50.0 and mixed 50.0
Conditions for overestimating vacation standards (Project No. 110)
5. Ethylmorphine hydrochloride (dionine). It is possible in eye drops and ointments up to 1.0, but for overestimation you need a doctor’s order “for a special purpose”, which is certified by the signature and personal seal of the doctor and the seal of the health care facility “for prescriptions”
6. Narcotic drugs, barbituric acid derivatives and potent drugs can be increased 2 times compared to what is indicated in the table for incurable cancer patients. There must be a written order from the head of the health care facility to assign the patient to the pharmacy to provide him with narcotic drugs.
7. Derivatives of barbituric acid, ephedrine, pseudoephedrine can be prescribed for a course of treatment of up to 1 month. The prescription must contain: a doctor’s instruction “for a special purpose,” which is certified by the doctor’s signature and the seal of the health care facility “for prescriptions.”
8. Ethyl alcohol for patients with chronic illness up to 100.0 in a mixture and in pure form. On the prescription: a doctor’s instruction “for a special purpose,” certified by the doctor’s signature and stamp “for prescriptions.”
On September 22, new rules for the dispensing of medicines came into force - order of the Ministry of Health of the Russian Federation dated July 11, 2017 No. 403n “On approval of the rules for dispensing medicines,” which regulates the sale of medicines in pharmacies. The document caused a lot of noise and confusion among both patients and pharmacy employees. Today we tried to answer the most important questions about the new order that an ordinary pharmacy visitor may have.
New order makes all drugs prescription drugs?
No. The new dispensing rules only slightly change how some prescription drugs are sold. It does not place any restrictions on common over-the-counter medications.
And now you can’t just buy a prescription drug?
Actually sell prescription drugs without a prescription has always been prohibited. For this, the pharmacy faces a considerable fine and loss of license. But, as everyone knows, the severity of the law is compensated by the optionality of its implementation. Therefore, a number of pharmacies ignore the rules. However, the emergence of new dispensing rules means close attention to their implementation, and therefore, pharmacies have now become more sensitive to prescription dispensing.
How do you even know if you need a prescription for the drug?
Whether the drug is prescription or not is stated in the instructions for use. In addition, such information is always indicated on the packaging. Of all drugs registered in Russia, approximately 70% are prescription drugs.
In an ideal world, the doctor knows by heart which drugs require a prescription and which do not. But in conditions harsh reality very often you have to check such information yourself. Therefore, when a doctor advises you on any medications, you can check them online right at your appointment and immediately ask for a prescription.
Prescriptions are written only on special forms. The most common is form No. 107-1/у. It looks like this:
To check whether a drug is a prescription drug, you can go to the website and enter the name of the drug. All prescription medications on our website are marked “prescription.” By the way, not so long ago we got a special label for drugs for which the prescription remains in the pharmacy.
How do you mean “the prescription stays at the pharmacy”?
The pharmacy has a list of drugs that are subject to strict registration. As a rule, these are medications containing narcotic or psychotropic substances included in a special list. Prescriptions for such drugs always remain in the pharmacy in order to control their sale. The circulation of narcotic substances is checked not only by Roszdravnadzor, but also by the structures of the Ministry of Internal Affairs.
But now, according to the new dispensing rules, the pharmacy must also keep prescriptions for certain medications (antidepressants, tranquilizers, antipsychotics, sleeping pills and sedatives, as well as for alcohol-containing medications with an alcohol content of more than 15%) *.
« Medicines containing alcohol"? So, now you need to get a prescription for Corvalol or valerian?
No. Let us repeat that new order does not make medications prescription drugs. We are talking only about prescription drugs. Corvalol, valerian tincture and many other popular tinctures and elixirs are over-the-counter. Accordingly, no one can require a prescription for them unless this is stated in the instructions for use.
Okay, let's say I have a prescription, but it contains several drugs, and one of them is marked "remains at the pharmacy." And I want to buy only one. Will they take my prescription?
Yes. Exceptions are made only for annual prescriptions, provided that you do not purchase the entire prescribed amount of the drug at one time (for this you also need the permission of the doctor who wrote the prescription).
For example, you are prescribed a course of antidepressants for a year, but you only need to purchase one package. In this case, the pharmacy does not have the right to take away your prescription. The pharmacist only makes a note of how much of the drug you bought and returns the prescription.
Can I get medications if the prescription is not written for me?
Yes. Almost all medicines are dispensed simply to the bearer of a prescription. Both the patient himself and his friend, relative, or just an acquaintance can get the drug at the pharmacy. The main thing is to have a recipe.
An exception is made only for narcotic or psychotropic drugs. Prescriptions for such drugs are written out on a special form No. 107/u-NP. It is easy to distinguish from other recipes because it is pink in color. When receiving such drugs at a pharmacy, you must have a power of attorney to receive medications and a passport confirming that you are the one for whom the power of attorney was issued.
At the same time, the Ministry of Health especially notes that the power of attorney can even be handwritten. You can write in it that “I trust such and such to receive such and such medications according to such and such a prescription to such and such a person.” And be sure to indicate the passport details of this person. In addition, it must indicate the date of its compilation. Notarization of such a power of attorney is not required.
What else has changed with the new procedure for dispensing medications?
Now all prescriptions are stamped with the statement that “the drug has been dispensed.” Thus, they cannot be reused. Therefore, if you suddenly need another standard of the drug, you will need to get a new prescription.
Also, the pharmacist is now obliged to inform the buyer about the rules for storing the medicine, its interaction with other drugs, as well as its method and dosage. In addition, a pharmacy employee cannot hide information about the availability of drugs with the same active ingredient, but cheaper. Such a norm existed previously in the law “On the Fundamentals of Protecting the Health of Citizens” and the Rules of Good Pharmacy Practice, but is now duplicated in the dispensing procedure.
* Below is a list of INNs, prescriptions for which, according to the new order, will now remain in the pharmacy. Please note that the active substances (INN) listed here are not specific brand names.
INN
agomelatine
asenapine
aminophenylbutyric acid
amisulpride
amitriptyline
aripiprazole
Belladonna alkaloids+Phenobarbital+Ergotamine
bromod
buspirone
venlafaxine
vortioxetine
haloperidol
hydrazinocarbonylmethy
hydroxyzine
dexmedetomidine
doxylamine
duloxetine
zaleplon
ziprasidone
Zuclopenthixol
imipramine
quetiapine
clomipramine
lithium carbonate
lurasidone
maprotiline
melatonin
mianserin
milnacipran
mirtazapine
olanzapine
paliperidone
paroxetine
pericyazine
perphenazine
pipofezin
pirlindole
podophyllotoxin
promazine
Common twig fruit extract
risperidone
sertindole
sertraline
sulpiride
tetra
tiapride
thioridazine
tofisopam
trazodone
trifluoperazine
morpho
fluvoxamine
fluoxetine
flupenthixol
fluphenazine
chlorpromazine
chlorprothixene
citalopram
escitalopram
etifoxine
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