When pain occurs, a person looks for a drug that can quickly relieve discomfort and restore full functioning. "Pentalgin" is one of the common analgesics offered in pharmacies. It is important to consider what kind of pain the drug helps with, what effect it has on the human body, and when its use is undesirable.
Form of release of the drug and its composition
The drug "Pentalgin" is a film-coated tablet. It is considered a combination drug because it contains several ingredients.
Pentalgin tablets consist of the following active substances(the dosage in one tablet is indicated in parentheses, mg):
- paracetamol (325);
- naproxen (100);
- caffeine (50);
- drotaverine hydrochloride (40);
- Pheniramine maleate (10).
In addition to the main active ingredients, the tablet core and the shell itself also include other ingredients. However, they do not have any therapeutic effect. The active substances are precisely the 5 above-mentioned medicinal compounds.
The medicine is packaged in cell membranes and carton boxes. In each, in addition to the drug itself, there is detailed instructions on the use of the product.
Pharmacological properties of the drug "Pentalgin"
The drug "Pentalgin" - combination remedy, which has an antispasmodic effect and has anti-inflammatory and antipyretic effects. The effect of the drug is determined by the reaction of the substances included in the composition.
Important take a closer look at how each component works medicinal product.
Properties of the drug according to active ingredients
Paracetamol. This active substance helps improve well-being when viral infection. The medicine helps eliminate pain, has an antipyretic effect. Paracetamol is used as part complex therapy in the treatment of infectious pathologies. Pain disappears by blocking the production of cyclooxygenase in the central nervous system, and by influencing thermoregulation centers in the brain.
This is a non-steroidal anti-inflammatory drug that has antipyretic and analgesic effects. The drug also has an effect on the production of cyclooxygenase, due to which the unpleasant symptoms, and relief comes. The production of prostaglandins, stimulators of inflammatory processes, is also suppressed.
This component of the drug "Pentalgin" increases the effect of using other drugs. Slightly expand blood vessels. The person experiences a surge of strength, weakness and drowsiness disappear. Caffeine has a psychostimulating effect, therefore it tones and improves well-being.
Drotaverine hydrochloride. This component helps eliminate spastic pain due to its relaxing effect. Smooth muscle fibers are affected by the medication. That is why the drug helps with pain in the internal organs, namely the gall and bladder, uterus.
This substance, contained in the Pentalgin tablet, has an antihistamine effect and has a mild sedative and relaxing effect. The component increases the activity of paracetamol and helps eliminate swelling and spasms.
Indications for use of the drug
The drug "Pentalgin" is prescribed to relieve pain of various etiologies. The drug is prescribed for the following conditions or diseases:
- pain in the teeth;
- menstrual pain;
- headache;
- pain syndrome in the joints;
- radiculitis;
- neuralgia;
- spastic pain;
- attack cholelithiasis;
- renal or hepatic colic;
- migraine.
"Pentalgin" for pain is also used in postoperative periods. Often at this time the patient is haunted strong pain, inflammatory processes are possible. The drug greatly facilitates the healing process and improves a person’s well-being.
Pentalgin is also prescribed for fever and colds. These tablets perform auxiliary functions to the main therapy and eliminate fever, muscle pain, and aches.
The drug is dispensed from a network of pharmacies without a prescription. Independent single use of Pentalgin is allowed provided there are no contraindications. If the drug must be taken for a long time, in a course, it is not recommended to do so without the recommendation of the attending physician.
Rules for using the product and dosage
The drug "Pentalgin" is taken entirely in tablet form. It is not chewed, but swallowed whole. You should not split the tablet into several doses - it is important to maintain the integrity of the shell. The medicine should be taken with the required amount drinking water. The duration of treatment can be individual, since much depends on the patient’s well-being and the indications for which the drug is used.
The medicinal drug "Pentalgin" is not recommended for the treatment of children. To reduce the negative impact of the tablets, the drug is prescribed to patients over 12 years of age.
If sudden pain occurs that is not associated with any pathology requiring planned treatment, Pentalgin tablets are taken once, one piece at a time. If you want to readmission, it is important to wait at least 4 hours, and only then take the second tablet.
Long-term pain syndromes require systemic use of medication. When treating the musculoskeletal system, the drug is taken for no more than 5 days, one tablet up to three times a day.
For elimination elevated temperature body and conditions associated with colds, Pentalgin is taken for no more than 3 days. The medication can also be taken 3 times a day, 1 tablet.
Specific dosages can be found by visiting a specialist. Do not exceed the maximum daily dose of the drug - 4 tablets. When therapy is carried out for a long time, medical monitoring and periodic testing are important.
Contraindications
However, the drug "Pentalgin" cannot always be taken. There are contraindications that must be taken into account.
Pentalgin tablets should not be taken in case of the following phenomena:
- during periods of exacerbation chronic diseases digestive organs;
- stomach and duodenal ulcers;
- hypersensitivity to the components of the drug;
- bronchospasm;
- bronchial asthma;
- nasal polyps;
- kidney and liver damage accompanied by failure;
- arrhythmic manifestations;
- tendency to bleed;
- persistent hypertension;
- severe vascular disorders;
- hyperkalemia;
- surgical interventions on the aorta;
- allergic reactions to aspirin or other drugs from the NSAID category.
It is prohibited to treat children under 12 years of age, since there is no data on how Pentalgin tablets act on young patients.
With caution, painkillers are prescribed to older patients, after 65 years. Negative phenomena may occur when treating people with epilepsy with Pentalgin, diabetes mellitus And chronic pathologies liver and kidneys.
The use of Pentalgin during pregnancy is prohibited, since the complex composition of the drug can cause damage to the fetus. This medicine is contraindicated for women who are breastfeeding.
Possible adverse reactions
During treatment with Pentalgin tablets, the following side effects may develop:
- itching of the skin and rash;
- nausea and vomiting;
- pain in the epigastric zone;
- stool disorders;
- changes in blood composition;
- decreased appetite;
- hand tremors;
- dizziness;
- insomnia;
- arrhythmic phenomena;
- angioedema shock;
- noise in ears.
If any symptoms appear during treatment negative reactions, it is important to inform your doctor about this. He will be able to select a drug that has a similar effect and does not cause unpleasant symptoms.
Overdose reaction
An overdose of the drug can cause serious conditions that require medical supervision. When consuming large doses without providing assistance, it is possible death. Signs of overdose appear 5 days after using increased doses.
Symptoms of overdose are:
- abdominal pain;
- nausea and vomiting like “coffee grounds”;
- confusion;
- lethargy and drowsiness;
- increased excitability;
- epilepsy attacks;
- severe liver failure.
In case of an overdose of Pentalgin, symptoms develop gradually. If a person mistakenly takes a large number of tablets, it is necessary to induce vomiting, rinse the stomach, give enterosorbents and immediately contact a medical facility.
"Pentalgin" has an antidote. This is Acetylcysteine. Whether to use it or not is decided after assessing the person’s condition. As a rule, therapy is symptomatic. The introduction of an antidote makes sense if no more than 8 hours have passed since the overdose.
Convulsions are possible intestinal bleeding, breathing disorders. Most of these conditions require close medical supervision.
Analogues of the drug "Pentalgin"
The drug "Pentalgin" has many analogues, since analgesics and antipyretics are used very often. Instead of this drug, the following medications are used:
- "Pentamialgin";
- "Plivalgin";
- "Pentalffen."
Some of the above-mentioned tablets contain narcotic components and are therefore available from pharmacies only with a prescription. If such a drug was prescribed by a doctor, there will be no problems purchasing it.
By following the manufacturer's instructions and avoiding uncontrolled use of medications, a person can save his life and health.
Pentalgin is a combined analgesic. Includes 5 active ingredients providing it pharmacological properties. These include caffeine, paracetamol, codeine, phenobarbital and metamizole sodium.
The medicine has analgesic, antispasmodic, anti-inflammatory and antipyretic properties. Pentalgin has been successfully used as a remedy symptomatic treatment in the treatment of colds accompanied by febrile conditions.
However, due to the presence of several highly active active elements, there is a wide range of contraindications for use and the risk of developing possible side effects increases.
Clinical and pharmacological group
Spasmoanalgesic.
Conditions for dispensing from pharmacies
Dispensed without a doctor's prescription.
Prices
How much do Pentalgin tablets cost in pharmacies? average price is at the level of 100 rubles.
Release form and composition
Dosage form – film-coated tablets: capsule-shaped, biconvex, light green to green in color, with beveled edges, lined on one side, embossed “PENTALGIN” on the other; The cut tablet is light green in color with white inclusions (2, 6, 10 or 12 tablets in a strip pack, 1 or 2 packs in a cardboard pack).
Active ingredients in 1 tablet:
- Paracetamol – 325 mg;
- Pheniramine maleate – 10 mg;
- Naproxen – 100 mg;
- Drotaverine hydrochloride – 40 mg;
- Caffeine – 50 mg.
Additional substances: hyprolose (hydroxypropylcellulose) (Klucel EF), magnesium stearate, croscarmellose sodium, potato starch, microcrystalline cellulose, talc, butylated hydroxytoluene (E321), citric acid monohydrate, indigo carmine (E132), quinoline yellow dye (E104).
Film shell composition: polysorbate 80 (Tween 80), povidone (medium molecular weight polyvinylpyrrolidone), talc, titanium dioxide, hypromellose (hydroxypropyl methylcellulose), indigo carmine (E132), quinoline yellow dye (E104).
Pharmacological effect
Pentalgin is a combined medication that has anti-inflammatory, antipyretic, analgesic and antispasmodic effects.
- Paracetamol is an antipyretic and analgesic substance, the effect of which is due to the inhibition of cyclooxygenase in the central nervous system and a direct effect on the thermoregulation and pain centers in the hypothalamus.
- Naproxen is a nonsteroidal anti-inflammatory drug with pronounced antipyretic and analgesic properties.
- Pheniramine belongs to the group of H1-histamine receptor blockers. It is an antispasmodic with a slight sedative effect. Enhances the analgesic properties of naproxen and paracetamol.
- Drotaverine has a myotropic antispasmodic effect, which is caused by suppression of the activity of the phosphodiesterase-4 enzyme.
- Caffeine stimulates the dilation of blood vessels in the heart, kidneys and skeletal muscles ah, improves physical endurance and mental performance, eliminates drowsiness and fatigue, and also increases the bioavailability of non-narcotic painkillers. Tones the blood vessels of the brain.
Indications for use
What does it help with? The use of Pentalgin is indicated for pain relief:
- Caused by spasm of smooth muscles (according to the instructions, the drug is effective, including renal colic, cholelithiasis, sphincter of Oddi dysfunction and a number of other diseases).
- Dental, headache (including pain associated with vasospasm in the brain), muscle or joint pain, as well as pain arising from algodismenorrhea, neuralgia, etc.
- Occurring against the background of trauma and surgical operations(including when pain is accompanied by development inflammatory process).
In addition, Pentalgin can be used for colds which are accompanied by febrile syndrome (used as a symptomatic antipyretic and analgesic).
Contraindications
Contraindications include:
- severe renal failure;
- gastrointestinal bleeding;
- severe arterial hypertension;
- inhibition of bone marrow hematopoiesis;
- hyperkalemia;
- frequent ventricular extrasystole;
- individual intolerance to the components included in the drug;
- erosive and ulcerative lesions of organs digestive system in the acute stage;
- condition after coronary artery bypass surgery;
- severe organic diseases of cardio-vascular system(for example, myocardial infarction);
- a combination of recurrent polyposis of the paranasal sinuses, nose, and bronchial asthma against the background of hypersensitivity to acetylsalicylic acid or other non-steroidal drugs;
- paroxysmal tachycardia;
- age up to 18 years.
It is not recommended to take Pentalgin during pregnancy, as well as during breastfeeding. The medication is prescribed with extreme caution in old age and in conditions such as: peripheral arterial disease, cerebrovascular diseases, alcoholic liver damage, epilepsy, liver and kidney failure. early stages, diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency, tendency to seizures, viral hepatitis, a history of ulcerative lesions of the digestive system and benign hyperbilirubinemia.
Use during pregnancy and lactation
The drug is contraindicated for use in pregnant women. The active ingredients included in the tablet can have a detrimental effect on the bookmark internal organs fetus and cause developmental abnormalities.
Since the components of the drug Pentalgin can be excreted in breast milk, the use of this drug for nursing mothers is contraindicated. If treatment is necessary, a woman should stop breastfeeding and temporarily transfer him to an adapted milk formula.
Dosage and method of administration
The instructions for use indicate that Pentalgin is prescribed orally, 1 tablet. 1-3 times/day. Maximum daily dose– 4 tab.
The duration of treatment is no more than 3 days as an antipyretic and no more than 5 days as an analgesic. Continuation of treatment with the drug is possible only after consultation with a doctor.
Do not exceed the indicated doses of the drug.
Side effects
With the development of a hypersensitivity reaction, skin rashes (urticaria) may appear and Quincke's edema may develop.
Possible side effects Pentalgina:
- hyperreflexia;
- shiver;
- dizziness;
- headache;
- insomnia;
- pain in the abdominal area;
- noise in ears;
- decreased acuity of auditory perception;
- rapid breathing;
- inhibition of hematopoiesis (manifested by anemia, thrombocytopenia and leukopenia);
- arterial hypertension (high blood pressure);
- violations heart rate;
- heartbeat;
- tachycardia;
- psycho-emotional arousal;
- unmotivated feeling of anxiety;
- impaired ability to concentrate;
- dyspeptic disorders;
- damage to the mucous membranes of the digestive organs (erosions and ulcers);
- decreased functional activity of the liver and (or) kidneys;
- cutaneous inflammatory reactions(dermatitis).
If at least one of the listed symptoms develops, treatment with the drug should be stopped and the doctor should be informed about side effects.
Overdose
In cases of using tablets long time in high doses, an overdose may occur, which is accompanied by symptoms: pale skin, anorexia, abdominal pain, nausea, vomiting, gastrointestinal bleeding, agitation, anxiety, confusion, tachycardia, arrhythmia, hyperthermia, increased urination, headaches, tremors, epileptic seizures and so on.
More severe forms of overdose are: development of liver failure with increasing encephalopathy, arrhythmia, pancreatitis, coma, death.
Typically treatment includes: gastric lavage, taking activated carbon, administration of a specific antidote - acetylcysteine or other drugs, depending on the symptoms.
special instructions
Before you start using the drug, read the special instructions:
- During the treatment period you should not drink alcoholic beverages.
- Paracetamol distorts results laboratory research glucose content and uric acid in blood plasma.
- When using the drug Pentalgin for more than 5-7 days, peripheral blood parameters and functional state liver.
- The effect of caffeine on the central nervous system depends on the type nervous system and can manifest itself as both excitation and inhibition of higher nervous activity.
- If it is necessary to determine 17-ketosteroids, Pentalgin should be discontinued 48 hours before the study. Please note that naproxen increases bleeding time.
- The simultaneous use of Pentalgin with other drugs containing paracetamol and/or NSAIDs, as well as with drugs to relieve symptoms of colds, flu and nasal congestion should be avoided.
During the treatment period, the patient must be careful when driving vehicles and engaging in other potentially dangerous species activities that require increased concentration and speed of psychomotor reactions.
Drug interactions
When using the drug, it is necessary to take into account interactions with other medications:
- Long-term use of barbiturates reduces the effectiveness of paracetamol.
- The simultaneous use of paracetamol with ethanol increases the risk of acute pancreatitis.
- Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic action of paracetamol.
- Paracetamol enhances the effect of indirect anticoagulants and reduces the effectiveness of uricosuric drugs.
- Concomitant use of caffeinated beverages and other CNS stimulants may result in excessive CNS stimulation.
- When used concomitantly, drotaverine may weaken the antiparkinsonian effect of levodopa.
- When taking the drug Pentalgin simultaneously with barbiturates, tricyclic antidepressants, rifampicin, ethanol, the risk of hepatotoxicity increases (these combinations should be avoided).
- Naproxen can cause a decrease in the diuretic effect of furosemide, an increase in the effect of indirect anticoagulants, increases the toxicity of sulfonamides and methotrexate, reduces the excretion of lithium and increases its concentration in the blood plasma.
- When used simultaneously with diflunisal, the plasma concentration of paracetamol increases by 50%, which increases the risk of developing hepatotoxicity.
- With simultaneous use of pheniramine with tranquilizers, hypnotics, MAO inhibitors, ethanol, the depressant effect on the central nervous system may be enhanced.
- At joint use caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin) may increase metabolism and increase caffeine clearance; while taking caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver (slowing its excretion and increasing its concentration in the blood).
Some facts about the product:
Instructions for use
Price in online pharmacy website: from 67
Some facts
Medicine Pentalgin was created to lower elevated body temperature and combat soreness in certain areas of the body caused by inflammation, spasm or other reasons.
Detailed composition and dosage form
A positive effect on thermoregulatory processes and the ability to eliminate pain and discomfort is provided by a combination of effects active ingredients contained in the medicine.
The active core of Pentalgin is represented by:
- Paracetamol - 0.325 g;
- Naproxen - 0.1 g;
- Caffeine - 0.05 g;
- Drotaverine hydrochloride - 0.04 g;
- Pheniramine maleate - 0.01 g.
In addition to active substances, when creating a medicine, auxiliary components are used that do not have clinical significance, but give the drug the necessary physical properties.
The product is produced in tablet form. Each pill is protected by a coating consisting of its own components that allow it to deliver medicinal substances into the required section of the intestine in an intact form.
The tablets have a light green or green color, oblong capsule-like biconvex shape and beveled edges. One side is divided by a line, and the other side is embossed with the name of the medicine in Latin letters. At the break, the pill has a greenish tint with whitish inclusions.
The medicine is packaged in PVC bags with individual contour cells of 2, 4, 6, 10 or 12 pills. A cardboard box may contain 1 or 2 identical blisters with medication and official instructions by application.
The drug is dispensed from the pharmacy without a prescription. Before using the product, you should obtain recommendations for use from your treating specialist.
Pharmacological possibilities
Medicinal effect the drug is explained by the complex influence of active substances, each of which has its own properties aimed at eliminating hyperthermia, inflammation, pain and improving general condition.
Paracetamol has the ability to reduce fever and reduce pain due to the formation of interactions that selectively block cyclooxygenase-3, which is active in the central nervous system. This action allows you to influence areas of the brain responsible for pain sensitivity and temperature regulation in the body.
Naproxen is a representative of nonsteroidal anti-inflammatory drugs derived from propion. The substance is able to suppress inflammatory processes and eliminate associated local or general hyperthermia. The drug does not selectively bind to prostaglandin endoperoxide synthases (cyclooxygenases), inhibiting the synthesis of prostaglandins.
The effect of caffeine is to temporarily improve the general condition of the body due to stimulation of nervous activity. The substance helps eliminate signs of fatigue, drowsiness, increases mental and mental stamina. physical activity. Additional effect What makes it possible to achieve a more pronounced effect from taking the drug is the ability of the substance to increase the permeability of the histiocytic barrier, which increases the bioavailability of analgesic components.
Drotaverine belongs to the category of myotropic antispasmodics. The substance blocks the action of phosphodiesterase-4, which leads to relaxation of smooth muscle tissue in the digestive tract, biliary tract, genitourinary system and vascular walls. Eliminating spasm allows you to get rid of pain.
The use of pheniramine allows one to achieve antihistamine activity, manifested in a decrease in the production of inflammatory fluid, increased effectiveness of analgesic components and a weak sedative effect.
Pharmacokinetic parameters differ for each of the active components.
The concentration of paracetamol reaches its maximum in the bloodstream 30-120 minutes after administration, and the half-life ranges from 50 to 240 minutes. The substance is biotransformed in the liver and excreted by the urinary system.
The highest levels of naproxen in the blood are observed 60-240 minutes after administration, and elimination of half the dose takes up to 13 hours. It is poorly metabolized, up to 95% is excreted through the renal system and about 5% through the intestines.
Caffeine is quickly and completely absorbed from the gastrointestinal tract, and the half-life lasts from 5 to 10 hours.
The maximum content of drotaverine in the blood is observed 2 hours after administration, and the half-life takes 120-240 minutes. The substance is excreted through the kidneys and bile.
Pheniramine reaches maximum plasma levels after 60-150 minutes, and the elimination time of half the dose is 16-19 hours (final phase). Up to 80% of the substance is excreted by the urinary system.
Indications for use
It is recommended to use Pentalgin to combat fever and cold symptoms, and pain (including headache, muscle, joint, dental, neuralgia, etc.) of weak and moderate intensity caused by inflammation, spasm of smooth muscle structures (cholecystitis, renal colic, etc.).
In the International Classification of Diseases (ICD-10), these conditions are coded: J06.9, K08.8, K80, K81.1, K91.5, M25.5, M54.1, M54.3, M54.4, M79 .1, M79.2, N23, N94.4, N94.5, R50, R51, R52.0, R52.2, T14.3.
Directions for use and dosage
The pills are taken whole and washed down with a sufficient volume of liquid. Single dose The medicine is presented in one tablet. It is recommended to take 1 to 3 pills per day. It is not recommended to use the drug more than four times a day (1 tablet).
In order to combat thermoregulation disorders (fever, hyperthermia), it is not recommended to use the medication for more than three days. To reduce pain, the permissible duration of therapy is 5 days.
If symptoms persist or reoccur, it is recommended to consult a doctor to change the dosage regimen or replace therapy.
The product is not used in pediatric practice (under 18 years of age).
The use of the drug is prohibited in case of severe functional liver and/or kidney pathologies.
Use by patients over 65 years of age requires additional monitoring.
Contraindications
Medical contraindications for the use of the medication are the following conditions:
- Individual intolerance to components;
- Severe pathologies in the functioning of the kidneys (creatinine clearance less than 30 ml per minute) and liver;
- Hematopoietic diseases;
- Glucose-6-phosphate dehydrogenase deficiency;
- Gastrointestinal bleeding, peptic ulcer in the acute period;
- A combination of bronchial asthma, nasal polyposis (paranasal sinuses) with a recurrent course, hypersensitivity to non-steroidal anti-inflammatory drugs;
- The period after installation of a coronary artery bypass graft;
- Paroxysmal tachycardia;
- Frequent ventricular tachycardia;
- A pronounced persistent increase in blood pressure;
- Severe pathologies of the circulatory system;
- Hyperkalemia;
- Under 18 years of age.
The drug requires careful use by patients with:
- Pathologies of cerebral circulation;
- Glucose metabolism disorders (diabetes mellitus);
- Diseases of the peripheral arteries;
- Past peptic ulcer disease;
- Benign hyperbilirubinemia;
- Mild to moderate functional abnormalities of the kidneys and liver;
- Viral hepatitis;
- Epilepsy and predisposition to seizures;
- Alcoholic hepatosis;
- Glucose-6-phosphate dehydrogenase deficiency.
If one or more factors from the list presented are present, the treating specialist should be notified.
Side effects
In most patients, the use of Pentalgin does not cause complications if medical instructions are followed. In progress clinical trials It has been established that the medicine can cause the following side effects:
- Pancyto-, leuko-, neutro-, thrombocytopenia, agranulocytosis, methemoglobinemia, anemia;
- Increased excitability, anxiety, increased reflexes, tremor, cephalalgia, dizziness, decreased ability to concentrate, insomnia, drowsiness;
- Palpitations, heart rhythm disturbances, arterial hypertension;
- Constipation, nausea, vomiting, abdominal pain, liver dysfunction, ulcerative lesions of the digestive tract mucosa, a feeling of heaviness in the epigastric region;
- Pathologies of renal functions;
- Tinnitus, hearing impairment, increased intraocular pressure with angle-closure glaucoma in a patient;
- Increased breathing rate;
- Rash, itching, angioedema, urticaria, anaphylaxis.
If side effects occur, you should consult a specialist for further recommendations on changing the dosage regimen or replacing therapy with another drug.
Overdose
The drug, when used in doses exceeding the permissible limits, can cause toxic damage liver structures with the concomitant occurrence of:
- Drowsiness;
- Paleness of the skin and mucous membranes;
- Nausea, vomiting;
- Loss of appetite;
- Hyperhidrosis;
- Epigastric pain.
In addition, as a result acute poisoning the following symptoms may occur:
- Anxiety, confusion;
- Heart rhythm disturbances;
- Promotions temperature indicators bodies;
- Pollakiuria;
- Cephalgia;
- Trembling fingers or involuntary muscle twitching;
- Convulsive seizures;
- Increased activity of liver enzymes.
A severe overdose can lead to:
- Failure of liver functions;
- Encephalopathy;
- Coma;
- Acute kidney failure;
- Lethal outcome.
The appearance of these signs indicates the need for urgent hospitalization for treatment. medical care. The following are prescribed as treatment: N-acetylcysteine, antacids, symptomatic drugs, enterosorbents and other detoxification medications.
Pregnancy and lactation period
Treatment with the drug during gestation and breastfeeding is prohibited.
The components of the product are able to penetrate into breast milk in small quantities, which makes it necessary to stop lactation during therapy with Pentalgin.
Drug interactions
Taking barbiturates, tricyclic antidepressants, rifampicin, ethanol (alcohol) in parallel with Petalgin increases Negative influence on the liver, which makes combining drugs from these groups undesirable.
The likelihood of liver toxicity is reduced with concurrent therapy with cimetidine or other microsomal oxidation inhibitors.
Diflunisal increases plasma paracetamol levels by 50%, which increases the likelihood negative impact to the liver.
Primidon, anticonvulsants accelerate the excretion of caffeine, and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin slow it down.
Tranquilizers, hypnotics, monoamine oxidase inhibitors increase the sedative effect of pheniramine.
Drotaverine reduces the effectiveness of levodopa in reducing signs of parkinsonism.
Storage conditions
Analogs
Analogs of Pentalgin in terms of the effect produced are: Rinza, Plivalgin, etc.
Pentalgin - combination drug, which is a pharmacological “cocktail” of five active substances. It has, first of all, an analgesic effect (a hint from the creators of the drug - the root “alg”), but, thanks to the presence of several not superfluous components in its composition, it also has a number of useful options, at the same time possessing antipyretic, antispasmodic and anti-inflammatory activity. Below we will talk in more detail about all “ characters» pentalgina.
Paracetamol is a non-narcotic pain reliever that also has an antipyretic effect. It primarily affects the pain and thermoregulation centers of the central nervous system. Naproxen is a non-steroidal anti-inflammatory drug that, in addition to pain relief and antipyretic, also has an anti-inflammatory effect, suppressing the synthesis of prostaglandins (inflammatory mediators). Caffeine dilates the blood vessels of the heart, skeletal muscles, kidneys, stimulates mental and physical activity, dispels drowsiness, tones the blood vessels of the brain. This substance is included in pentalgin for one more reason: it increases the permeability of blood vessels, thereby increasing the bioavailability of the analgesic component and, as a result, its therapeutic effect.
Drotaverine causes relaxation of smooth muscles of the digestive and genitourinary tract, cardiovascular and biliary systems. Pheniramine blocks H1-histamine receptors, which play important role in the development of the inflammatory process. The substance has an antispasmodic and sedative effect and enhances the effect of the analgesic components of the drug.
A single dose of pentalgin is 1 tablet. The drug is taken 1-3 times a day, in extreme cases - 4 times, but no more. The duration of treatment depends on the purpose for which pentalgin is used: if as an antipyretic, then no more than 3 days, but if as an analgesic, then treatment can be extended up to 5 days, after which the drug can be continued only with the consent of the doctor.
It is not advisable to combine Pentalgin with cold medications, as well as with other drugs containing paracetamol. It's not so harmless medicine, especially when the recommended doses are exceeded, which can be easily seen by reading about its side effects.
Pharmacology
The combined drug has analgesic, anti-inflammatory, antispasmodic, antipyretic effects.
Paracetamol is an analgesic-antipyretic, has an antipyretic and analgesic effect due to the blockade of COX in the central nervous system and its effect on the centers of pain and thermoregulation.
Naproxen is an NSAID that has anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of COX activity, which regulates the synthesis of prostaglandins.
Caffeine is a psychostimulant that causes dilation of the blood vessels of skeletal muscles, heart, and kidneys; increases mental and physical performance, helps eliminate fatigue and drowsiness; increases the permeability of histohematic barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect. It has a tonic effect on the blood vessels of the brain.
Drotaverine - has a myotropic antispasmodic effect due to inhibition of PDE 4, acts on the smooth muscles of the gastrointestinal tract, biliary tract, genitourinary system, vessels.
Pheniramine is a histamine H1 receptor blocker. It has an antispasmodic and mild sedative effect, reduces exudation, and also enhances the analgesic effect of paracetamol and naproxen.
Pharmacokinetics
Data on the pharmacokinetics of the drug Pentalgin ® are not provided.Release form
Light green to green film-coated tablets, biconvex, capsule-shaped with beveled edges, scored on one side and embossed "PENTALGIN" on the other; When cut, the tablet is light green in color with white splashes.
Excipients: microcrystalline cellulose, potato starch, croscarmellose sodium, hyprolose (hydroxypropylcellulose) (Klucel EF), citric acid monohydrate, butylated hydroxytoluene (E321), magnesium stearate, talc, quinoline yellow dye (E104), indigo carmine (E132).
Film shell composition: hypromellose (hydroxypropyl methylcellulose), povidone (medium molecular weight polyvinylpyrrolidone), polysorbate 80 (Tween 80), titanium dioxide, talc, quinoline yellow dye (E104), indigo carmine (E132).
2 pcs. - contour cellular packaging (1) - cardboard packs.
2 pcs. - contour cell packaging (2) - cardboard packs.
6 pcs. - contour cellular packaging (1) - cardboard packs.
6 pcs. - contour cell packaging (2) - cardboard packs.
10 pieces. - contour cellular packaging (1) - cardboard packs.
10 pieces. - contour cell packaging (2) - cardboard packs.
12 pcs. - contour cellular packaging (1) - cardboard packs.
12 pcs. - contour cell packaging (2) - cardboard packs.
Dosage
The drug is prescribed orally, 1 tablet. 1-3 times/day. The maximum daily dose is 4 tablets.
The duration of treatment is no more than 3 days as an antipyretic and no more than 5 days as an analgesic. Continuation of treatment with the drug is possible only after consultation with a doctor.
Do not exceed the indicated doses of the drug.
Overdose
Symptoms: pallor skin, anorexia (lack of appetite), abdominal pain, nausea, vomiting, gastrointestinal bleeding, agitation, motor restlessness, confusion, tachycardia, arrhythmia, hyperthermia (increased body temperature), increased urination, headache, tremor or muscle twitching; epileptic seizures, increased activity of liver transaminases, hepatonecrosis, increased prothrombin time. Symptoms of liver dysfunction may appear 12-48 hours after an overdose. In case of severe overdose, liver failure develops with progressive encephalopathy, coma, and death; acute renal failure with tubular necrosis; arrhythmia, pancreatitis. If you suspect an overdose, you should immediately seek medical help.
Treatment: gastric lavage followed by taking activated charcoal. The specific antidote for paracetamol poisoning is acetylcysteine. The administration of acetylcysteine is important within 8 hours after taking paracetamol. At gastrointestinal bleeding introduction required antacids and gastric lavage with ice-cold 0.9% sodium chloride solution; maintaining pulmonary ventilation and oxygenation; at epileptic seizures- intravenous administration of diazepam; maintaining fluid and salt balance.
Interaction
When taking the drug Pentalgin ® simultaneously with barbiturates, tricyclic antidepressants, rifampicin, ethanol, the risk of hepatotoxicity increases (these combinations should be avoided).
Paracetamol enhances the effect of indirect anticoagulants and reduces the effectiveness of uricosuric drugs.
Long-term use of barbiturates reduces the effectiveness of paracetamol.
When used simultaneously with paracetamol and ethanol, the risk of acute pancreatitis increases.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic action of paracetamol.
Diflunisal increases the plasma concentration of paracetamol by 50%, which increases the risk of hepatotoxicity.
Naproxen can cause a decrease in the diuretic effect of furosemide, an increase in the effect of indirect anticoagulants, increases the toxicity of sulfonamides and methotrexate, reduces the excretion of lithium and increases its concentration in the blood plasma.
With the combined use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin), it is possible to increase metabolism and increase the clearance of caffeine; while taking caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver (slowing its excretion and increasing its concentration in the blood).
Concomitant use of caffeinated beverages and other CNS stimulants may result in excessive CNS stimulation.
When used concomitantly, drotaverine may weaken the antiparkinsonian effect of levodopa.
With simultaneous use of pheniramine with tranquilizers, hypnotics, MAO inhibitors, ethanol, the depressant effect on the central nervous system may be enhanced.
Side effects
Allergic reactions: skin rash, itching, urticaria, angioedema.
From the hematopoietic system: thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia.
From the side of the central nervous system: agitation, anxiety, increased reflexes, tremor, headache, sleep disturbances, dizziness, decreased concentration.
From the cardiovascular system: palpitations, arrhythmias, increased blood pressure.
From the digestive system: erosive and ulcerative lesions of the gastrointestinal tract, nausea, vomiting, epigastric discomfort, abdominal pain, constipation, impaired liver function.
From the urinary system: impaired renal function.
From the senses: hearing loss, tinnitus, increased intraocular pressure in patients with angle-closure glaucoma.
Other: dermatitis, tachypnea (increased breathing).
If any of the side effects indicated in the instructions get worse, or the patient notices any other side effects not listed in the instructions, he should inform the doctor.
Indications
- pain syndrome of various origins, including pain in the joints, muscles, radiculitis, algodismenorrhea, neuralgia, toothache, headache (including those caused by cerebral vasospasm);
- pain syndrome associated with spasm of smooth muscles, incl. at chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, renal colic;
- post-traumatic and postoperative pain syndrome, incl. accompanied by inflammation;
- colds accompanied by fever (as symptomatic therapy).
Contraindications
- erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
- gastrointestinal bleeding;
- complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance acetylsalicylic acid or other NSAIDs (including in history);
- severe liver failure;
- severe renal failure;
- inhibition of bone marrow hematopoiesis;
- condition after coronary artery bypass surgery;
- heavy organic diseases cardiovascular system (incl. acute heart attack myocardium);
- paroxysmal tachycardia;
- frequent ventricular extrasystole;
- severe arterial hypertension;
- hyperkalemia;
- pregnancy;
- lactation period (breastfeeding);
- children's and adolescence up to 18 years old;
- hypersensitivity to the components of the drug.
The drug should be used with caution in patients with cerebrovascular diseases, diabetes mellitus, peripheral arterial diseases, a history of ulcerative lesions of the gastrointestinal tract, with mild or moderate renal and hepatic insufficiency, viral hepatitis, alcoholic liver damage, benign hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), epilepsy, with a tendency to seizures, glucose-6-phosphate dehydrogenase deficiency, in elderly patients. If any of the listed diseases and conditions, the patient should consult a doctor before using the drug.
Features of application
Use during pregnancy and breastfeeding
The use of the drug is contraindicated during pregnancy and lactation (breastfeeding).Use for liver dysfunction
Use is contraindicated in severe liver failure.Use for renal impairment
Use is contraindicated when renal failure severe.Use in children
Contraindication: children and adolescents under 18 years of age.special instructions
The simultaneous use of Pentalgin ® with other drugs containing paracetamol and/or NSAIDs, as well as with drugs to relieve symptoms of colds, flu and nasal congestion should be avoided.
When using the drug Pentalgin ® for more than 5-7 days, peripheral blood counts and the functional state of the liver should be monitored.
Paracetamol distorts the results of laboratory tests of glucose and uric acid in blood plasma.
If it is necessary to determine 17-ketosteroids, Pentalgin ® should be discontinued 48 hours before the study. Please note that naproxen increases bleeding time.
The effect of caffeine on the central nervous system depends on the type of nervous system and can manifest itself as both excitation and inhibition of higher nervous activity.
During the treatment period, the patient should avoid drinking alcohol.
Impact on the ability to drive vehicles and operate machinery
In some cases, a decrease in concentration and speed of psychomotor reactions is possible, therefore, during the treatment period, the patient should be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
"Pentalgin" is an antispasmodic and anti-inflammatory drug.
pharmachologic effect
Anti-inflammatory, antispasmodic, analgesic, and antipyretic - these are the effects that the drug "Pentalgin" has. Its composition combines active components, which is why Pentalgin has such a good therapeutic effect.
Components included in the drug
- Naproxen, which belongs to the group of anti-inflammatory drugs non-steroidal drugs, which has direct antipyretic, analgesic and anti-inflammatory effects associated with improved prostaglandin synthesis.
- Drotaverine affects the smooth muscles of the gastrointestinal tract, genitourinary system, as well as the biliary tract and blood vessels.
- Paracetamol, which has antipyretic and analgesic properties, blocks COX in the central nervous system and has a depressing effect on the centers of pain and thermoregulation.
- By toning the blood vessels of the brain, caffeine dilates the blood vessels of the kidneys, heart and skeletal muscles, eliminating drowsiness. Since caffeine is a psychostimulant, it, by increasing the bioavailability of non-narcotic analgesics, as well as increasing the permeability of histohematological barriers, significantly increases the therapeutic effect.
- Pheniramine has an antispasmodic and sedative effect, enhancing the analgesic effect of active ingredients such as naproxen and paracetamol.
During pregnancy, Pentalgin is not recommended for use, since some of the active components included in this drug are able to penetrate the placenta.
"Pentalgin": release form and composition
"Pentalgin" is produced in the form of biconvex green tablets, coated with a film with the word PENTALGIN embossed on one side - "Pentalgin".
Composition of one tablet
Many people are interested in what the composition of the drug “Pentalgin” is? The advantage of this drug is that there are no “extra” substances inside, and all the components help get rid of pain. Here it is, the composition of one tablet:
- paracetamol - 325 mg;
- pheniramine maleate - 10 mg;
- caffeine - 50 mg;
- naproxen - 100 mg;
- drotaverine hydrochloride - 40 mg.
"Pentalgin". Indications for use
"Pentalgin" with drotaverine, according to the instructions, is used for:
- pain syndrome of various origins, including toothache, algodismenorrhea, neuralgia, radiculitis, joint and muscle pain and headache;
- colds that are accompanied by fever;
- pain syndrome, which is caused by spasm of smooth muscles, which, in turn, occurs with postcholecystectomy syndrome, cholelithiasis, renal colic, chronic cholecystitis;
- post-traumatic and postoperative pain syndrome.
Contraindications for the use of Pentalgin according to the instructions
- Lesions of the gastrointestinal tract (erosive-ulcerative) in the acute phase.
- Severe renal failure.
- A combination of polyposis of the paranasal sinuses and nose and bronchial asthma against the background of intolerance to non-steroidal drugs (including acetylsalicylic acid).
- Renal failure (severe).
- The rehabilitation period after coronary artery bypass surgery.
- Severe arterial hypertension.
- Paroxysmal tachycardia.
- Inhibition of bone marrow hematopoiesis.
- Ventricular extrasystole (frequent).
- Gastrointestinal bleeding.
- Organic diseases of the cardiovascular system in severe form, myocardial infarction in acute form inclusive.
- Under the age of 18.
- During hypersensitivity to the components of the drug "Pentalgin".
- Hyperkalemia.
It is not recommended to use Pentalgin during breastfeeding and pregnancy, and also with caution for elderly people and if they have:
- peripheral arterial diseases;
- cerebrovascular diseases;
- liver and kidney failure, moderate and mild degree heaviness;
- liver damage from alcohol;
- deficiency of glucose-6-phosphate dehydrogenase;
- epilepsy;
- diabetes mellitus;
- viral hepatitis;
- history of ulcerative lesions of the gastrointestinal tract;
- tendency to have seizures;
- benign hyperbilirubinemia (Rotor, Dubin-Johnson and Gilbert syndromes inclusive).
Method of use of the drug "Pentalgin"
You should not take more than 4 Pentalgin tablets per day.
- As an antipyretic drug, Pentalgin should not be taken for more than 3 days. With absence positive result you need to see a doctor to clarify the diagnosis.
- According to the instructions, Pentalgin should be taken as a pain reliever for up to 5 days.
To use the drug more long term, you need to discuss this with your doctor. If Pentalgin is prescribed during pregnancy, it must be done as soon as possible. Do not exceed the dose of the drug "Pentalgin". The composition of the drug contains substances that can cause an overdose, manifested as:
- bleeding in the gastrointestinal tract;
- excitation;
- lack of appetite;
- tachycardia;
- motor restlessness;
- headache;
- increased activity of liver transaminases;
- frequent urination;
- change in skin color (pallor);
- change in prothrombin time (increase);
- muscle twitching or tremors;
- confusion;
- vomiting, abdominal pain, nausea;
- hepatonecrosis;
- arrhythmia;
- change in body temperature (increase).
You should be careful when taking caffeine-containing products and drinks along with taking the drug Pentalgin. The drug already contains caffeine, and increasing the dose can lead to overstimulation of the nervous system and unnecessary stress on the heart.
