Unfortunately, in some cases, termination of pregnancy is necessary. And the safest today is considered to be a medical abortion, which, however, is possible only in the initial stages. For this purpose, a drug such as Misoprostol is often used. Instructions, features of composition and impact are important questions, the answers to which are worth reading. So what is the medicine?
The drug "Misoprostol": composition and information on the release form
First you need to familiarize yourself with some general data. This medicine is available in the form of white round tablets. They are packaged in convenient blisters of three. The packaging consists of one blister.
Misoprostol tablets contain one active ingredient - misoprostol powder (200 mg in each tablet). Of course, other substances are also used to make the drug, in particular hypromellose, silicon dioxide (colloidal), microcrystalline cellulose, sodium carboxymethyl starch, as well as Castor oil.
How does the product affect the body?
To begin with, it is worth saying that misoprostol is a synthetic derivative of natural prostaglandin E1. This substance causes dilation of the cervix and contraction of the smooth muscles of the myometrium. Thus, the medicine significantly increases the tone of the uterus, which in some cases can provoke termination of pregnancy.
In addition, the drug also affects the activity of the digestive tract. Misoprostol binds to the receptors of the parietal cells of the stomach and inhibits the secretion of both gastric enzymes and hydrochloric acid.
Along with this, under the influence of the drug, activation of the synthesis of mucus and bicarbonates is observed. Thus, irritant effect gastric juice on cells is significantly reduced. The medicine increases the resistance of the tissues of the digestive tract, prevents the development peptic ulcer, improves blood flow and cell nutrition, and also promotes the healing of existing erosions.
It is worth noting that this medicine has virtually no effect on the functioning of the cardiovascular, respiratory and endocrine systems.
When is the drug used?
Most often this drug is used for medical termination of pregnancy. We are, of course, talking about initial period- no more than 42 days from the moment of fertilization.
There are other cases in which it is advisable to use the drug Misoprostol. Reviews from doctors indicate that the medicine is effective in treating some forms of peptic ulcer gastrointestinal tract, erosive gastritis and some other diseases.
Instructions for use for abortion
If we are talking about artificial termination of pregnancy, then this medicine is used in combination with Mifepristone. First, the woman takes Mifepristone, and after 36-48 hours - Misoprostol tablets. As a rule, a single dose is 400 mg of the active substance.
It is worth immediately noting that such a procedure can only be carried out in a hospital setting - the patient must be constantly under observation medical personnel. The fact is that after taking the pill, extensive vaginal bleeding is possible.
How long does it take for Misoprostol to work? In most cases, miscarriage occurs 6 hours after taking the pill. Occasionally, the process of termination of pregnancy takes longer - up to 1 week.
8-15 days after the procedure, the woman must come for a gynecological examination and an ultrasound procedure. An analysis of sex hormone levels is also recommended.
"Misoprostol" in the treatment of diseases of the digestive tract
As already noted, this drug affects the smooth muscles of the digestive tract, and in high doses it inhibits the secretion of gastric juice. That is why this drug is sometimes used for the treatment and prevention of gastric ulcers, erosive gastritis(if the pathology is caused by long-term use of non-steroidal anti-inflammatory drugs).
How to take Misoprostol correctly? The instructions contain information that patients take 200 mcg of the active substance 2-4 times a day. It is advisable that the last dose of the medicine be taken immediately before bedtime. The maximum amount of the drug is 400-800 mcg per day.
Information about the presence of contraindications
Can it be used in all cases? medicine Misoprostol? The instructions compiled by the manufacturer contain information about the presence of restrictions on use. You should definitely familiarize yourself with the list of contraindications before taking the pill.
- The patient has hypersensitivity (allergy) to any of the components included in the tablets.
- Some kidney and liver diseases.
- Pathologies and dysfunctions of the heart and blood vessels.
- Pathologies associated with prostaglandin dependence.
- Glaucoma, increased arterial pressure, bronchial asthma (these diseases are a contraindication to the use of prostaglandins).
- Diseases of the endocrine glands, including pathologies of the adrenal glands and pancreas (diabetes mellitus).
- The presence of tumors, the growth of which depends on the level of sex hormones.
- Anemia.
- Tablets should not be taken if you suspect ectopic pregnancy, since drug interruption in in this case may cause serious complications.
- The drug is contraindicated in patients who use intrauterine contraceptives. Before the procedure, the doctor must remove the intrauterine device.
- The medicine should not be taken during lactation. There is a need to use tablets, then breast-feeding must be stopped for at least 7 days.
- This drug is not prescribed to girls under 18 years of age.
Are there any possible side effects?
Are there any complications possible with the use of the drug Misoprostol? The instructions contain information that the drug does sometimes cause side effects. It's worth reading their descriptions.
- Most often, women encounter disorders of the genitourinary system. Sometimes patients experience nagging pain in the lower abdomen, which are caused by contraction of the muscle fibers of the uterus. Bloody discharge after Misoprostal is also possible. To the list side effects include violations menstrual cycle, too much or, conversely, scanty discharge during menstruation.
- In some cases, after taking the pills, allergic reactions are possible, which are manifested by skin itching, redness, and swelling. Rarely reported cases angioedema and anaphylactic reactions.
- Many patients experience dyspeptic symptoms, constipation, and flatulence. These side effects usually go away on their own a few days after the procedure.
- Other side effects may also develop. Their list includes changes in body weight (too quick loss or weight gain), headaches, asthenic conditions, hyperthermia, increased fatigue and dizziness.
How much does the medicine cost?
It's no secret that for many patients important factor is the cost. How much will Misoprostol cost? The cost of a package consisting of three tablets ranges from 2500 to 3000 rubles. Of course, some people find the price high. However, the cost of substitutes is about the same.
The drug "Misoprostol": analogues
This remedy is not always suitable for patients. Problems may be associated both with the presence of contraindications and with the inability to obtain medicine. What to do in such cases? Is it possible to replace the drug Misoprostol with something?
Analogues of the drug, of course, exist. For example, medications such as Mirolut and Cytotec are used for the same purpose. The list of possible substitutes also includes Prepidil, Dinoprobioston, and Enzaprost tablets.
It is worth understanding that these are powerful medications that can only be used in a hospital setting. Self-medication in this case is extremely dangerous, as it can pose a threat not only to the health, but also to the life of the woman. The selection of a substitute can only be entrusted to the treating gynecologist.
One tablet contains 200 mcg misoprostol .
The following excipients are used: micronized silica gel, sodium carboxymethyl starch, hydrogenated ricin oil and microcrystalline cellulose.
Release form
Available in round tablets white. The cardboard package contains one blister for 3 or 4 pcs.
pharmachologic effect
Renders gastroprotective , antiulcer And uterotonic effect , and stimulates labor .
Pharmacodynamics and pharmacokinetics
Misoprostol is synthetic derivative E1 . It is capable of inducing contraction of the smooth muscles of the myometrium and dilation of the cervix, which facilitates the process of excretion of the contents of the uterine cavity. Due to the weak stimulating effect on the smooth muscles of the gastrointestinal tract, large doses inhibit secretion, and the tablets act as antiulcer agent .
Misoprostol as an active substance does not have a significant clinical effect on:
- level gonadotropins ;
- thyroid-stimulating hormones ;
- aggregation
Pharmacokinetics
Oral administration leads to rapid absorption (max concentration - 6.08±1.64 mg/ml). When taken with meals, especially fatty ones, it decreases bioavailability drug without affecting the duration of absorption. In the walls of the gastrointestinal tract and liver there is a transformation to active diesterified – misoprostol acid , the maximum concentration of which is reached after half an hour and is 499 mg/ml. The half-life is no more than 30 minutes; the substance does not accumulate in body tissues and is excreted primarily by the kidneys.
Indications for use
- erosion , and erosive and ulcerative lesions of the gastrointestinal tract due to therapy with other drugs and prevention of their ulcerogenic effects (for example, prevention and treatment NSAID gastropathy );
- , including exacerbations;
- for early termination (no more than 42 days).
Contraindications
- hypersensitivity to the drug, as well as to other prostaglandins and analogues;
- liver dysfunction;
- cardiovascular or endocrine diseases;
- severe form;
- contraindications for the use of prostaglandins –, arterial hypertension ;
- reception VPZ ;
- inflammatory processes in the intestines , including ;
- , suspicion of , (breastfeeding);
- age group up to eighteen years.
Side effects
Towards various bodies and systems Misoprostol can cause the following adverse reactions:
- Gastrointestinal organs: abdominal pain , nausea , vomit , or .
- Genitourinary system : various menstrual cycle disorders, postmenopausal vaginal bleeding, hypermenorrhea , abundant uterine bleeding , most often caused by contractions of the myometrium. During the pre- and postmenopausal period - convulsions .
- The cardiovascular system: hypo- or hypertension .
- Skin: rash , .
- Allergic reactions And .
- Other reactions: , asthenia , change in body weight, hyperthermia and/or chills .
Instructions for Misoprostol (Method and dosage)
Misoprostol in combination with is taken according to the following scheme:
- 3 tablets (600 mg) of Mifepristone - orally on an empty stomach or two hours after a meal.
- After 36–48 hours - 2 tablets on an empty stomach. (400 mcg) Misoprostol.
Attention! If after taking there is no bleeding for 2 days, then taking the pills on your own is prohibited. To prescribe an additional dosage, you should consult a doctor - visit an obstetrician for 2-3 days.
Instructions for use of Misoprostol: antiulcer drug involves taking tablets orally with meals. Dosage: 200 mcg 3-4 times a day, a single dose in the range of 200-400 micrograms if the patient has hypersensitivity or - the dose is 100 micrograms. How to take and for how long - should be calculated depending on the indications and observed clinical picture treatment.
Overdose
Misoprostol has not been shown to be toxic to humans. Clinical manifestations overdoses can be expressed as, seizures , abdominal pain , increased heart rate, arterial hypotension or bradycardia . Treatment should be symptomatic.
Interaction
- With antacids plasma concentration of Misoprostol decreases;
- With antacids containing magnesium — possible strengthening;
- With acenocoumarol a case of decreased anticoagulant effect was recorded acenocoumarol ;
- s , - increasing their side effects.
Terms of sale
Dispensed by prescription.
Storage conditions
In a dry, dark place, out of reach of children. At a temperature environment no more than 25°C.
Best before date
Store for no more than two years.
Synonyms
, Cytotec .
During pregnancy and lactation
Based on the type of effect on the fetus, the drug is classified in category (according to the FDA) - X.
Misoprostolic acid is able to penetrate into breast milk. Despite the fact that there is no information about the development of any adverse reactions in children, it is recommended to use Misoprostol with caution.
If the drug is used as:
- Gastroprotective agent: pregnancy or planning it is unacceptable, since increased tone uterus may provoke. The drug can be prescribed only after whey test for pregnancy, remaining negative for at least 2 weeks. Misoprostol is usually started 2-3 days after starting menstrual cycle , prerequisite is the use reliable methods of contraception , for example, barrier ones.
- Uterotonic: use for the purpose of termination of pregnancy, otherwise the drug is contraindicated in case of planned pregnancy.
Analogues of Misoprostol
Level 4 ATX code matches:- Misoprostol-HPMC;
- Cytotech.
Misoprostol: instructions for use and reviews
Latin name: Mizoprostol
ATX code: A02BB01
Active substance: misoprostol
Manufacturer: China Resources Zizhu Pharmaceutical Co. Ltd. (China Resources Zizhu Pharmaceutical, Co. Ltd) (China)
Updating the description and photo: 09.09.2019
Misoprostol is a drug used for medical termination of pregnancy.
Release form and composition
The drug is produced in the form of tablets: round, white (3 pieces each in aluminum blisters with aluminum coating, 1 blister and instructions for use of Misoprostol in a cardboard box).
1 tablet contains the active substance - misoprostol powder HPMC (hydroxypropyl methyl cellulose) in a ratio of 1:99:
- Misoprostol – 0.2 mg;
- Hypromellose – 19.8 mg.
Auxiliary components: sodium carboxymethyl starch, microcrystalline cellulose, castor oil, colloidal silicon dioxide.
Pharmacological properties
Pharmacodynamics
Misoprostol is a synthetic derivative of prostaglandin E1.
The substance induces contraction of myometrial smooth muscle fibers and dilation of the cervix. Thanks to the ability to stimulate uterine contractions, the opening of her cervix and the removal of the contents of the uterine cavity are facilitated.
Misoprostol after taking mifepristone can induce or increase the strength and frequency of spontaneous uterine contractions.
The drug has a weak stimulating effect on the smooth muscles of the gastrointestinal tract. When used in large doses, inhibition of gastric juice secretion occurs.
Pharmacokinetics
After oral administration, misoprostol is rapidly absorbed, being completely absorbed after 1.5 hours. The maximum concentration of misoprostolic acid (the active metabolite) in the blood plasma when taking a dose of 200 mg averages 0.309 mcg/l and is achieved in 15 minutes.
Misoprostolic acid is excreted from the body primarily by the kidneys, with a half-life ranging from 36 to 40 minutes.
Indications for use
Misoprostol is prescribed for termination of pregnancy early stages(up to 42 days of amenorrhea) in combination with the use of mifepristone.
Contraindications
- Diseases of the cardiovascular system;
- Endocrinopathies and diseases endocrine system, including adrenal dysfunction and diabetes mellitus;
- Kidney and liver diseases;
- Diseases associated with prostaglandin dependence, as well as contraindications to the use of prostaglandins, including bronchial asthma, glaucoma, arterial hypertension;
- Anemia;
- Hormone-dependent tumors;
- The use of intrauterine contraceptives (the drug can be taken after their removal);
- Suspicion of ectopic pregnancy;
- Lactation period;
- Hypersensitivity to the components of the drug.
Misoprostol, instructions for use: method and dosage
Misoprostol tablets are taken orally, 2 pcs. (0.4 mg) 36-48 hours after taking 3 mifepristone tablets.
For the purpose of terminating pregnancy, the drug should be used in institutions with personnel trained to carry out the procedure.
Side effects
When using Misoprostol in the early stages of pregnancy, nausea, vomiting, lethargy, dizziness, and pain in the lower abdomen may develop.
In extremely rare cases, the following may occur: flushing of the face, itching, increased body temperature, allergic reactions.
Overdose
Misoprostol toxicity has not been demonstrated in humans.
The main symptoms of overdose: abdominal pain, drowsiness, increased heart rate, convulsions, tremor, fever, bradycardia or hypotension.
special instructions
Misoprostol tablets for termination of pregnancy in the early stages must be used simultaneously with mifepristone. The procedure can only be performed in specialized medical institutions that have the capabilities to provide emergency surgical blood transfusion and gynecological care.
Before taking the drug, the patient's condition should be monitored for 4-6 hours. After using Misoprostol, in cases of massive bleeding or the development of other complications, qualified medical advice should be provided. health care.
In approximately 80% of women, after taking Misoprostol, a miscarriage occurs within 6 hours, in 10% - within 7 days.
8-15 days after using the drug in the same medical institution should be re-examined. If necessary, an ultrasound is performed or the level of human chorionic gonadotropin in the blood serum is determined. If you suspect continued pregnancy or an incomplete abortion, you must promptly carry out a comprehensive medical examination. When the diagnosis is confirmed 10-14 days after taking Misoprostol, it is necessary to conduct vacuum aspiration followed by histological examination of the aspirate in order to assess the effect of the drug on the formation birth defects development in the fetus.
Impact on the ability to drive vehicles and complex mechanisms
Since dizziness and other side effects that negatively affect concentration and speed of psychomotor reactions may occur after taking the drug, caution should be exercised when driving vehicles.
Use during pregnancy and lactation
Misoprostol during pregnancy can only be used to terminate it, otherwise the drug is strictly contraindicated because it has a teratogenic effect. In women taking this drug, therapy should be discontinued when pregnancy is established.
If there is a suspicion of an ectopic pregnancy, the use of the drug is contraindicated.
Breastfeeding should be stopped for 7 days from the date of taking mifepristone in the method medical abortion(for 5 days from the date of use of Misoprostol).
For impaired renal function
For kidney disease, taking the drug is contraindicated.
For liver dysfunction
For liver diseases, taking the drug is contraindicated.
Drug interactions
Long-term use of antidepressants, isoniazid, rifampicin, anticonvulsants, cimetidine, acetylsalicylic acid, barbiturates, indomethacin, as well as smoking more than 10 cigarettes per day reduces the level of Misoprostol in the blood serum (due to an increase in its metabolism).
For 7 days after taking Misoprostol, it is recommended to stop using aspirin and other non-steroidal anti-inflammatory drugs.
Analogs
Analogs of Misoprostol are: Mirolut, Cytotec, Misoprostol-HPMC.
Terms and conditions of storage
Store in a dry, dark place, out of reach of children, at temperatures up to 25°C.
Shelf life – 2 years.
In this article you can read the instructions for use of the drug Misoprostol. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Misoprostol in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Misoprostol in the presence of existing structural analogues. Use for the treatment of stomach ulcers and termination of pregnancy (medical abortion) in combination with Mifepristone in adults, children, as well as during pregnancy and lactation.
Misoprostol- a synthetic analogue of prostaglandin E1. It has a cytoprotective effect associated with an increase in the formation of mucus in the stomach and an increase in the secretion of bicarbonate by the gastric mucosa. Having a direct effect on the parietal cells of the stomach, misoprostol suppresses basal, nocturnal and stimulated (food, histamine, pentagastrin) secretion. Reduces basal (but not histamine-stimulated) pepsin production.
Induces contraction of myometrial smooth muscle and dilates the cervix. Increases the frequency and strength of myometrial contractions, having a slight stimulating effect on the smooth muscles of the gastrointestinal tract.
The action begins after 30 minutes and lasts for at least 3-6 hours. At a dose of 50 mcg, the effect is moderate and short, at 200 mcg it is pronounced.
Compound
Misoprostol + excipients.
Pharmacokinetics
When administered orally, it is quickly and completely absorbed (food delays absorption). Plasma protein binding is 85%. In the walls of the gastrointestinal tract and liver it is metabolized to pharmacologically active misoprostolic acid. Does not accumulate with repeated doses. Excreted by the kidneys (80%) and bile (15%).
Indications
- prevention of the development of gastric ulcers associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs) in patients with increased risk ulceration;
- treatment of exacerbation of peptic ulcer duodenum;
- stomach ulcer.
In combination with mifepristone: termination of pregnancy in the early stages (up to 42 days of amenorrhea).
Release forms
Tablets 200 mcg.
Instructions for use and dosage regimen
The dosage regimen is determined individually, depending on the indications.
For the prevention of stomach ulcers caused by non-steroidal anti-inflammatory drugs, and the treatment of erosive gastritis and peptic ulcers of the stomach and duodenum: 200 mcg 2-4 times a day (last dose - before bedtime); daily dose - 400-800 mcg. If tolerance is poor, the single dose may be reduced to 100 mcg. At renal failure daily dose reduced by 50%.
To terminate pregnancy (in combination with mifepristone): 400 mcg of misoprostol is prescribed 36-48 hours after taking mifepristone.
Side effect
- abdominal pain;
- flatulence;
- nausea, vomiting;
- diarrhea;
- constipation;
- pain in the lower abdomen associated with contractions of the myometrium;
- dysmenorrhea;
- polymenorrhea;
- menorrhagia;
- metrorrhagia;
- skin rash;
- Quincke's edema;
- change in body weight;
- asthenia;
- increased fatigue;
- convulsions (in pre- or post-menopausal women).
Contraindications
- severe liver dysfunction;
- inflammatory bowel diseases;
- pregnancy;
- lactation period;
- severe renal failure;
- enteritis;
- children and adolescents up to 18 years of age;
- hypersensitivity to misoprostol.
Use during pregnancy and breastfeeding
Contraindicated for use during pregnancy and lactation (breastfeeding).
It must be taken into account that misoprostol increases the tone of the uterus and can cause miscarriage when used as a gastroprotective agent.
If use is necessary in women of childbearing age, a serum pregnancy test should be performed first, which should remain negative for 2 weeks before starting misoprostol therapy. Treatment can be started only on the 2-3rd day normal menstruation. During the entire course of treatment, reliable methods of contraception should be used.
Use in children
Contraindicated in children and adolescence up to 18 years old.
special instructions
Use with caution in patients with arterial hypotension, coronary artery disease, cerebral circulation, coronary artery sclerosis, epilepsy, enterocolitis, diarrhea, hypersensitivity to prostaglandins or their analogues.
Use for termination of pregnancy is carried out only in combination with mifepristone and only in specialized medical institutions with appropriately trained medical personnel and the ability to provide emergency gynecological surgical and blood transfusion care. The drug is not sold in a regular pharmacy.
The use of the drug requires the prevention of Rh conflict and other general measures accompanying abortion. Before prescribing misoprostol, the patient should be informed in detail about the action and possible side effects of the drug. The patient should be observed in a medical facility for 4-6 hours before taking the drug. During and after taking the drug, the patient should be provided with timely medical assistance in case of massive bleeding or the development of other complications. After taking the drug, patients, as a rule, experience slight vaginal bleeding, and in some women it is very prolonged. In very early pregnancy, abortion is possible after taking mifepristone, but in this case it is also necessary to take misoprostol tablets to optimize the results of medical abortion. After taking misoprostol, approximately 80% of women experience abortion within 6 hours and approximately 10% of women within 1 week. The patient must undergo a re-examination in the same medical institution 8-15 days after taking the drug. If necessary, an ultrasound scan or determination of the level of human chorionic gonadotropin in the blood serum should be performed. If you suspect an incomplete abortion or continued pregnancy, it is necessary to conduct a comprehensive medical examination in a timely manner. In case of incomplete abortion or ongoing pregnancy, assessed 10-14 days after taking mifepristone, vacuum aspiration must be performed, followed by histological examination of the aspirate.
Taking the drug as a gastroprotector should be stopped if diarrhea occurs (mild diarrhea is not considered a reason to discontinue treatment, the drug is discontinued in case of severe diarrhea - approximately 2% of cases), skin itching, bloody discharge from the vagina, lowering blood pressure and increasing transaminase activity.
Misoprostol should not be given within 1 week of taking misoprostol. acetylsalicylic acid and other NSAIDs.
Drug interactions
When used simultaneously with antacids, the concentration of misoprostol in the blood plasma decreases.
When used simultaneously with magnesium-containing antacids, diarrhea may increase.
When used simultaneously with acenocoumarol, a case of a decrease in the anticoagulant effect of acenocoumarol has been described.
When used simultaneously with diclofenac and indomethacin, the side effects of diclofenac and indomethacin increase.
Analogues of the drug Misoprostol
Structural analogues according to active substance:
- Misoprostol HPMC;
- Peaceful;
- Cytotech.
Analogues pharmacological group(medical abortion products):
- Pencrofton;
- Resonant;
- Enzaprost F.
If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.
On this moment An increasing number of women are resorting to termination of pregnancy through medical abortion. This method of getting rid of an unwanted pregnancy is considered the most common today. In order to perform a medical abortion, many methods are used. various drugs. One such drug is Misoprostol.
Misoprostol is a prostaglandic hormonal agent , which can suppress inflammatory processes in a woman’s body. Initially, the drug was created to treat diseases of the gastrointestinal tract and peptic ulcers, however, today the drug is used to eliminate unwanted pregnancies.
The drug began to be used for medical abortions due to its side effect in the form of softening of the cervix. According to the instructions, the drug must be taken in the first weeks of pregnancy. It is important to remember that before using the drug, you must consult with your doctor to avoid negative consequences.
Misoprostol: instructions for use
Indications for use
Misoprostol should be used in the following cases:
- If women wish to terminate pregnancy in the early stages.
- If the patient has diseases of the gastrointestinal tract.
- If the patient has stomach diseases and duodenal ulcers.
In what cases is the use of the drug Misoprostol contraindicated?
The use of the drug is contraindicated:
- If the patient has an individual intolerance to any component of the drug.
- During breastfeeding.
- If the patient is under 18 years of age.
The drug contains such active ingredients as misoprostol and hypromellose . Excipients are:
- Sodium carboxymethyl starch.
- Castor oil.
- Microcrystalline cellulose.
- Silicon dioxide colloidal.
How to use the medicine and in what dosage?
In order to terminate an unwanted pregnancy using medical abortion, you must first take the medicine Misoprostol, its dosage should be 200 mg, and the medicine should be washed down with plenty of water. After about 26 hours have passed it is necessary take 2 tablets of Misoprostol, one tablet contains 200 mg of active substance.
Misoprostol must be taken in combination with the drug in order to achieve the desired result. The Misoprostol tablet cannot be chewed; it can be placed under the tongue, used intravaginally and placed between the lip and gum. It is not recommended to dissolve two tablets at once; it is better to do it one at a time.
It is necessary to carry out termination of pregnancy only in a hospital setting and under the strict supervision of a gynecologist. Before surgical intervention it is necessary to warn the woman about possible negative consequences. The patient should arrive at the clinic 4–6 hours before the intended administration of Misoprostol. This must be done so that the gynecologist can monitor the woman’s condition before and after taking the medicine.
If a woman’s pregnancy is short, then termination of pregnancy can occur after taking Mifeprostone, but it is still necessary to take Misoprostol after this drug to obtain an accurate result. Many women are interested in how long does it take for Misoprostol to work? For most women, abortion occurs within 6 days, but for some, the process can take up to two weeks. After 1.5–2 weeks have passed since the abortion, the woman should undergo a medical examination.
The best remedy take before eating, since the medicine interacts with food and its concentration in the blood decreases. In this case desired result may not be achieved. It is best to use the medicine 2-3 hours before and after administration. If you take Misoprostol tablets together with fatty foods, then in this case the fat will prevent the product from penetrating into the blood.
Overdose
Symptoms of overdose have currently only been studied in animals. But scientists are confident that overdose symptoms will also appear in humans. . An overdose may manifest itself:
Side effects
Using this medicine may cause great amount side effects, which appear:
- as pain syndrome in the abdominal area;
- in the form of dyspepsia;
- in the form of flatulence;
- in the form of nausea;
- in the form of vomiting;
- in the form of diarrhea;
- in the form of constipation;
- in the form of a rash;
- in the form of skin itching;
- in the form of anaphylactic shock;
- in the form of Quincke's edema;
- in the form of a headache;
- in the form of asthenic syndrome;
- in the form of high fatigue;
- in the form of an increase in body temperature;
- in the form of chills;
- in the form of a convulsive syndrome.
Usually all of the above symptoms appear within the first 2-3 days after taking the drug.
Concomitant use of drugs and alcohol
Categorically It is prohibited to drink alcoholic beverages while taking Misoprostol. This cannot be done for the reason that active ingredients the medicine begins to interact with alcohol and, as a result, the effectiveness of Misoprostol decreases. But, also, alcohol can cause complications on a woman’s body or other side effects.
Misoprostol release form
Misoprostol is available for abortion in the form of 0.2 mg tablets. Tablets are in blisters, and blisters are in cardboard packages. The drug is dispensed only with a doctor's prescription. Misoprostol price is 300–350 rubles.
Misoprostol: analogues
The main analogues of Misoprostol are Cytotec and Mirolut. There are analogs of Misoprostol that are not as popular as the previous ones, but no less effective. These include the following:
- Pencrofton.
Cytotech- this is a medicine whose purpose is to create conditions for termination of pregnancy in the early stages. The drug is produced in the form of tablets, which are in blisters and in cardboard boxes. The medicine is produced in Greece. After taking the pills, pregnancy is terminated within 30 minutes. The drug must be taken strictly under the supervision of the attending physician. The cost of the medicine is 250 rubles.
Represents medicinal product, causing medical abortion. The drug is produced in Russia. The medicine is available in tablet form for internal use. The tablets cost 300 rubles.
Miropriston is a drug that is intended for medical abortion in the early stages. The manufacturer of this drug is China. The main substance of this drug is mifepristone. Miropriston is produced in the form of tablets for internal use. The recommended dose of tablets is 600 milligrams. After 36 hours have passed since taking the drug, an ultrasound is performed. The entire procedure, from starting to take the pill to performing an ultrasound, should be supervised by a gynecologist. The cost of such a drug is 700 rubles.
Pencrofton is a medicine that is produced by a Russian pharmacological company and is intended to terminate pregnancy in the early stages. Active substance The drug is represented by mifepristone. The drug must be taken under the supervision of a gynecologist at a dosage of 600 milligrams. IN Russian pharmacies Pencrofton can be purchased for 500 rubles. The drug is available in tablet form.
Mifegin is a drug produced by a French pharmaceutical company. The medicine is available in tablet form. After taking the pills, the patient must remain under the supervision of a gynecologist for at least 2 hours. A few days after taking the drug, the doctor should perform an ultrasound examination of the patient. The cost of the drug is within 3500 rubles.
Misoprostol: reviews
I have been working as an obstetrician for 10 years. For some reason, only recently in our medical practice has entered medicinal method termination of an unwanted pregnancy. From the moment we started practicing it, more and more pregnant women began to come to us. Now we perform abortions with the help of the drug Misoprostol; it has a rather gentle effect on the woman’s body, but it is true that it causes terrible nausea, which for a long time does not pass. An unwanted pregnancy is terminated after 30 minutes.
Ekaterina Teterina
I am a gynecologist and whether I like it or not, I have to perform abortions according to various reasons I can’t do without this in my profession. Getting rid of an unwanted pregnancy through medical abortion is now the most popular method of terminating a pregnancy. To terminate a pregnancy this way, I use the drug Misoprostol. It acts quickly and the consequences of its use are minimal.
Lisa Nevskaya
It so happened that my sister unexpectedly became pregnant, but she did not want to give birth, because at that time she could not provide for the unborn child. My sister decided to have an abortion and went to the hospital to see a gynecologist. The termination of pregnancy had to occur medicinally, that is, with the help of drugs that were supposed to cause a miscarriage. The doctor told my sister to first take a Misoprostol tablet and within half an hour she had a miscarriage. Then my sister developed some side effects: headache, nausea and slight bleeding, but it all stopped quickly. Such a drug, as it turns out, is often prescribed to induce abortion.
Lyudmila Kamyshina
