Latin name: IbuclinComposition and release form: Pills, film-coated 400 mg + 325 mg. Composition (1 table): 10 tablets in a PVC/Al blister. 1, 2 or 20 blisters are packed in a cardboard pack with instructions for use. Capsule-shaped, orange-coated tablets with a score line on one side; For individual tablets, marbling of color is allowed. A combined drug whose effect is determined by its constituent components. Ibuprofen– a non-steroidal anti-inflammatory drug (NSAID), has an analgesic, anti-inflammatory, antipyretic effect. By inhibiting cycloxygenase (COX) 1 and 2, it disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins (mediators of pain, inflammation and hyperthermic reaction), both at the site of inflammation and in healthy tissues, suppresses exudative and proliferative phase inflammation. Paracetamol– indiscriminately blocks COX, mainly in the central nervous system, has little effect on water-salt metabolism and mucous membrane gastrointestinal tract(Gastrointestinal tract). Has an analgesic and antipyretic effect. In inflamed tissues, peroxidases neutralize the effect of paracetamol on COX 1 and 2, which explains the low anti-inflammatory effect. The effectiveness of the combination is higher than that of individual components. Ibuprofen. Absorption is high, quickly and almost completely absorbed from the gastrointestinal tract (GIT). The time to reach maximum concentration (TC max) after oral administration is about 1-2 hours. Communication with blood plasma proteins is more than 90%. The half-life (T 1/2) is about 2 hours. It slowly penetrates into the joint cavity, accumulates in the synovial fluid, creating higher concentrations in it than in the blood plasma. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. Metabolized. More than 90% is excreted by the kidneys (no more than 1% unchanged) and, to a lesser extent, with bile in the form of metabolites and their conjugates. Paracetamol. Absorption is high, binding to plasma proteins is less than 10% and increases slightly with overdose. Sulfate and glucuronide metabolites do not bind to plasma proteins even at relatively high concentrations. The C max value is 5-20 μg/ml, TC max is 0.5-2 hours. Distributed fairly evenly in body fluids. Penetrates the blood-brain barrier. About 90-95% of paracetamol is metabolized in the liver to form inactive conjugates with glucuronic acid (60%), taurine (35%) and cysteine (3%), as well as a small amount of hydroxylated and deacetylated metabolites. A small portion of the drug is hydroxylated by microsomal enzymes to form highly active N-acetyl-n-benzoquinone imine, which binds to the sulfhydryl groups of glutathione. When glutathione reserves in the liver are depleted (in case of overdose), the enzyme systems of hepatocytes can be blocked, leading to the development of their necrosis. T1/2 – 2-3 hours. In patients with liver cirrhosis, T1/2 increases slightly. In elderly patients, drug clearance decreases and T1/2 increases. It is excreted by the kidneys mainly in the form of glucuronide and sulfate conjugates (less than 5% unchanged). IN breast milk less than 1% of the dose of paracetamol penetrates. In children, the ability to form conjugates with glucuronic acid is lower than in adults. Reducing elevated body temperature (febrile syndrome) during colds and other infectious diseases inflammatory diseases.
Pain syndrome of weak or moderate intensity of various etiologies: The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, and does not affect the progression of the disease. Basic: Carefully: ischemic disease hearts; chronic heart failure; cerebrovascular diseases; dyslipidemia/hyperlipidemia; diabetes; peripheral arterial disease; smoking; Cl creatinine less than 60 ml/min; history of ulcerative lesions of the gastrointestinal tract; presence of infection; elderly age; long-term use of NSAIDs; alcoholism; severe somatic diseases; simultaneous use of oral corticosteroids (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), SSRIs (including citalopram, fluoxetine, paroxetine, sertraline ); viral hepatitis; liver and/or renal failure of moderate and mild degree heaviness; benign hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndrome); cirrhosis of the liver with portal hypertension; nephrotic syndrome. If it is necessary to use the drug Ibuklin® during pregnancy and lactation (breastfeeding), you should carefully weigh the expected benefits of therapy for the mother and the potential risk to the fetus or child. If use is necessary in the first trimester of pregnancy, long-term use of the drug Ibuklin® should be avoided. If short-term use of the drug Ibuklin® is necessary during lactation, cessation of breastfeeding is usually not required. In experimental studies The embryotoxic, teratogenic and mutagenic effects of the components of the drug Ibuklin® have not been established. Inside, before or 2–3 hours after meals, without chewing, with a sufficient amount of water. Adults. 1 table each 3 times a day. The maximum daily dose is 3 tablets. Children over 12 years old (body weight more than 40 kg). 1 table each 2 times a day. The duration of treatment is no more than 3 days as an antipyretic and no more than 5 days as an analgesic. Continuation of treatment with the drug is possible only after consultation with a doctor. From the gastrointestinal tract: NSAID gastropathy (nausea, vomiting, heartburn, anorexia, epigastric discomfort or pain, diarrhea, flatulence); rarely - erosive and ulcerative lesions, bleeding, liver dysfunction, hepatitis, pancreatitis, irritation or dryness in the mouth, pain in the mouth, ulceration of the gum mucosa, aphthous stomatitis, constipation. From the nervous system and sensory organs: headache, dizziness, insomnia, anxiety, nervousness, irritability, agitation, drowsiness, depression, confusion, hallucinations; rarely - aseptic meningitis (more often in patients with autoimmune diseases), hearing loss, tinnitus, visual impairment, toxic damage optic nerve, blurred vision or double vision, scotoma, amblyopia. From the SSS side: heart failure, increased blood pressure, tachycardia. From the hematopoietic organs: anemia (including hemolytic and aplastic), thrombocytopenia, thrombocytopenic purpura, agranulocytosis, leukopenia. From the respiratory system: shortness of breath, bronchospasm. From the urinary system: allergic nephritis, acute renal failure, nephrotic syndrome, edema, polyuria, cystitis. Allergic reactions: skin rash, itching, urticaria, angioedema, bronchospasm, dyspnea, allergic rhinitis, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids, eosinophilia, fever, anaphylactic shock, exudative erythema multiforme (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome). Laboratory indicators: decreased serum glucose concentration, decreased hematocrit and hemoglobin, increased bleeding time, increased serum creatinine concentration, increased liver transaminase activity. Others: increased sweating. With long-term use in high doses: ulceration of the gastrointestinal mucosa, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), blurred vision (impaired color vision, scotoma, amblyopia). Symptoms: gastrointestinal disorders (diarrhea, nausea, vomiting, anorexia, pain in the epigastric region), increased PV, bleeding after 12–48 hours, lethargy, drowsiness, depression, headache, tinnitus, impaired consciousness, disorders heart rate, decreased blood pressure, manifestations of hepato- and nephrotoxicity, convulsions, possible development of hepatonecrosis. If you suspect an overdose, you should immediately seek medical help. Treatment: gastric lavage during the first 4 hours; alkaline drinking, forced diuresis; administration of activated carbon, administration of SH-group donors and the precursor of glutathione synthesis - methionine - 8–9 hours after an overdose and N-acetylcysteine orally or intravenously after 12 hours, antacid drugs; hemodialysis; symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration. When taken simultaneously with acetylsalicylic acid, ibuprofen reduces its anti-inflammatory and antiaggregation effect (an increase in the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiaggregation agent is possible after starting ibuprofen). Combination with ethanol, corticosteroids, and corticotropin increases the risk of erosive and ulcerative lesions of the gastrointestinal tract. Ibuprofen enhances the effect of direct (heparin) and indirect (coumarin and indanedione derivatives) anticoagulants, thrombolytic agents (alteplase, anistreplase, streptokinase, urokinase), antiplatelet agents, colchicine - increases the risk of developing hemorrhagic complications. Strengthens the hypoglycemic effect of insulin and oral hypoglycemic drugs. Weakens the effects of antihypertensive drugs and diuretics (due to inhibition of renal PG synthesis). Increases the blood concentration of digoxin, lithium and methotrexate. Caffeine enhances the analgesic effect of ibuprofen. Cyclosporine and gold preparations increase nephrotoxicity. Cefamandole, cefoperazone, cefotetan, valproic acid, plicamycin increase the incidence of hypoprothrombinemia. Antacids and cholestyramine reduce the absorption of the drug. Myelotoxic medicines contribute to the manifestation of hematotoxicity of the drug. The advisability of using the drug as an antipyretic is decided in each case depending on the severity, nature and tolerability of the febrile syndrome. To reduce the risk of developing adverse events from the gastrointestinal tract, you should use minimal effective dose the shortest possible course. With the simultaneous use of indirect anticoagulants, it is necessary to monitor the indicators of the blood coagulation system. Should be avoided joint reception the drug Ibuklin® with other NSAIDs. To avoid possible damaging effects on the liver, you should not drink alcohol while taking the drug. With long-term (more than 5 days) use of the drug, monitoring of peripheral blood and functional state liver. The drug may distort the results of laboratory tests when quantification glucose, uric acid in blood serum, 17-ketosteroids (the drug must be discontinued 48 hours before the study). Effect on ability to drive vehicles, mechanisms. In a dry place, protected from light and out of reach of children, at a temperature not exceeding 25 °C.
Relieves arthralgia at rest and during movement, reduces morning stiffness and swelling of joints, and helps increase range of motion.
During the treatment period, the patient should refrain from potentially dangerous species activities requiring increased attention and speed of psychomotor reactions.
Ibuklin is a typical member of a group of drugs called non-steroidal anti-inflammatory drugs. According to the international classification, the drug belongs to anti-inflammatory and antirheumatic drugs, which are derivatives of ibuprofen and its combinations.
ATX code
M01AE51 Ibuprofen in combination with other drugs
Active ingredients
Ibuprofen
Paracetamol
Pharmacological group
Non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs
pharmachologic effect
Analgesic (non-narcotic) drugs
Anti-inflammatory drugs
Indications for use Ibuklin
Thanks to complex composition the drug has wide range effects, which ensures its use in many areas of medicine.
Thus, indications for the use of Ibuklin include severe hyperthermia, and the fever may have a different genesis of origin. These can be either colds or more serious infectious diseases with severe inflammation.
Ibuklin copes well with pain, but its degree should not be excessively great. The drug relieves the average intensity of pain in the presence of an inflammatory focus in the bones, joints and muscles, for example, with gouty or rheumatoid arthritis, ankylosing spondylitis.
Indications for the use of Ibuklin in the fight against pain include degenerative processes in joints and bone structures with deforming osteoarthritis and osteochondrosis.
The drug is effective for tendovaginitis and bursitis, when the periarticular capsule is involved in the process. Lumbago, neuralgia, muscle pain, as well as post-traumatic injuries from dislocations, sprains, fractures and bruises are also grounds for the use of Ibuklin.
Release form
The main characteristics of this pharmaceutical product are its release form, which is represented by a tablet preparation, as well as its physicochemical properties. They involve coating each tablet with a film coating, the shade of which varies from light orange to a more saturated color.
It is also worth highlighting the capsule-like shape, which has a dividing strip on one side and a smooth surface on the other.
The release form in the form of tablets determines the packaging of the drug. So, Ibuklin comes with 10 tablets in one blister, which corresponds to one cardboard package.
Each tablet contains 400 mg ibuprofen and 323 mg paracetamol. In addition to the main components, there are several additional ones, for example, cellulose, starch, glycerin and others.
The tablet form is very convenient to use, since thanks to the specific composition of each tablet, you can strictly monitor the dose and avoid overdose.
Pharmacodynamics
Pharmacodynamic properties are determined by the main components included in the drug - ibuprofen and paracetamol.
Each of the above components has certain capabilities, which in combination with another component provides a pronounced therapeutic effect.
The pharmacodynamics of Ibuklin is a complex of actions of both drugs, which have an analgesic and anti-inflammatory effect. By blocking cyclooxygenases, the drug not only reduces the symptoms inflammatory reaction, but also acts as an antipyretic.
As for paracetamol, it is not capable of providing a pronounced anti-inflammatory effect on its own, since its activity is inhibited by peroxidases. As a result, Ibuklin additionally contains ibuprofen to enhance the therapeutic effect.
The components of the drug, having a combined effect, provide a reduction in pain in the joints, which in turn leads to a decrease in stiffness in the joints. motor activity and returns the previous joint mobility.
Pharmacokinetics
The complex drug consists of two main active drugs, therefore the pharmacokinetics of Ibuklin is based on the combined action of both components.
Thus, ibuprofen quickly penetrates into the general bloodstream through the mucous membrane of the digestive organs after oral use. Within a couple of hours its maximum concentration in plasma is observed.
Almost 99% of ibuprofen binds to plasma proteins, with which it is carried through the bloodstream. Excretion of ibuprofen is carried out by filtration by the kidneys in unchanged form or in the form of oxidized metabolites in an inactive form.
In the above ways, all ibuprofen metabolites are eliminated from the body within 24 hours, and after 24 hours the person completely gets rid of the drug.
The pharmacokinetics of Ibuklin, which contains paracetamol, is due to good absorption. Half an hour after taking the tableted drug orally, the concentration of paracetamol in the bloodstream reaches its maximum value. This level remains for 4 hours and gradually begins to decrease.
As for the connection with blood proteins, paracetamol is transported in combination with them only in a partial amount (approximately 25%). After 1.5-2 hours, only half of the taken dosage remains in the human body. Metabolism occurs in the liver with the formation of glucuronides and sulfates. Paracetamol is excreted by the kidneys, gradually decreasing the concentration in the blood and increasing in the urine.
Use of Ibuklin during pregnancy
Throughout the entire period of pregnancy and after childbirth, when the baby is on breastfeeding, any medication should be taken under the supervision of a physician. This is due to the high probability of the drug reaching the child.
The use of Ibuklin during pregnancy is permitted if the benefit to the expectant mother is significantly greater than the harm to the fetus. During the experiments, it was concluded that Ibuklin is not capable of exerting a mutagenic or teratogenic effect.
You need to use medications especially carefully in the first trimester of pregnancy, when gradual development of fetal organs is observed. Subsequently, their formation and development occurs.
The use of Ibuklin during pregnancy usually does not cause harm to the woman and the fetus, however, it is necessary to strictly control the dosage and duration of use of the drug in order to avoid negative impact for the fruit.
Contraindications
In order for the drug to provide therapeutic effect without appearing adverse reactions and worsening of the condition, you need to know the contraindications to the use of Ibuklin.
These include the age of children under 12 years old, the individual characteristics of the body, when responses to the administration of a certain medicinal component are genetically determined. Also, contraindications to the use of Ibuklin include the presence of ulcerative defects in the mucous membrane of the digestive organs and bleeding in the acute phase.
It is not recommended to take Ibuklin in case of renal failure in the stage of decompensation, with combined pathology of the paranasal sinuses with bronchial asthma, polyposis and an allergic reaction to acetylsalicylic acid.
In addition, Ibuklin is not advisable for use in cases of damage to the optic nerve, pathology of the circulatory system, early period after coronary artery bypass surgery, as well as in severe liver pathology, inflammatory bowel diseases and an increased amount of potassium in the blood.
In addition to absolute contraindications, there are also relative contraindications, which include metabolic pathology, heart disease, vascular disorders, simultaneous use of hormones, anticoagulants, antiplatelet agents and NSAIDs.
Monitoring is necessary when taking Ibuklin over a long period of time.
Side effects of Ibuklin
The main side effects of Ibuklin, as in many other cases of taking medications, are allergic reactions. They may appear in connection with individual characteristics body immunity. As a result, oral administration of the drug may result in a powerful immune system response, manifested by various clinical symptoms.
Most often, you can observe a rash of various diameters and shapes, tingling sensations, itching, up to the development of urticaria and Quincke's edema. In addition, manifestations include pain in the stomach and abdomen, nausea, slight dizziness, vomiting, headache and visual impairment.
Side effects of Ibuklin may also relate to impaired renal function, the appearance of erosive damage to the mucous membrane of the digestive organs and changes in the blood picture with a decrease in the number of platelets, red blood cells, changes in the size of blood cells, hyperkalemia, hyperuricuria and azotemia.
If pain occurs in the stomach and vomiting, it is necessary to monitor the color of the vomit. If it reminds " coffee grounds", then you need to urgently call ambulance. These symptoms signal the onset of gastric bleeding.
In addition, bleeding from the intestines is indicated by the appearance of blood in the stool (the so-called melena). This condition also requires immediate medical intervention.
Directions for use and doses
The tablet form of the drug involves taking it orally a couple of hours before or after meals. The tablet should not be chewed and should not be swallowed whole with a few sips of water.
The method of administration and dosage of medications are selected individually, taking into account the degree of illness, age and health status of the person.
Since children under 12 years of age do not have permission to take this drug, at an older age adults can use it, 1 tablet up to 3 times a day. It is necessary to maintain a certain interval between taking the medication, which should not be less than 4 hours.
Please note that a single dose of the tableted drug Ibuklin is a maximum of 2 tablets, and for a daily dosage - a maximum of 6 tablets.
The method of administration and dose should be adjusted in elderly people, as well as in the presence of concomitant pathology severe. So, their break between doses of the drug should not be less than 8 hours.
Without medical supervision, the use of Ibuklin as an antipyretic drug is approximately 3 days, and as an analgesic drug - no more than 5 days.
If drug Ibuklin must be taken long time, then the functioning of the liver, kidneys and the state of the circulatory system should be monitored using laboratory research methods.
Overdose
If the dosage and duration of administration are not observed, the likelihood of an overdose increases. In this case, certain nonspecific symptoms may suggest an accumulation effect of the drug and an increase in its side effects.
An overdose of Ibuklin can manifest itself in the form of digestive disorders with nausea, vomiting and pain in the epigastric zone. Also possible Clinical signs hepatotoxic syndrome, disturbances of consciousness, headache, decrease blood pressure and paleness of the skin.
If such symptoms are observed, it is necessary to carry out some procedures that will remove metabolites and drug residues.
So, you first need to rinse the stomach so that part of the drug that has not yet been absorbed can be eliminated from the body. In addition, it is necessary to take Activated carbon, which is a sorbent. It will also help block further entry of the drug into the bloodstream.
Overdose in some cases requires hemodialysis and monitoring of the blood picture. If the balance of electrolytes is disturbed, the deficiency should be replenished and the indicators returned to normal.
Interactions with other drugs
People who abuse alcoholic beverages should not use Ibuklin at the same time due to the fact that the likelihood of liver damage increases.
Interaction of Ibuklin with other drugs, for example, those affecting coagulation circulatory system, is undesirable, as the risk of erosive damage to the mucous membrane of the digestive tract and the development of bleeding increases.
Manufacturer: Dr. Reddys Laboratories Ltd. (Dr. Reddis Laboratories Ltd.) India
PBX code: M01AE51
Farm group:
Release form: Solid dosage forms. Pills.
General characteristics. Compound:
Active ingredients: ibuprofen 100 mg, paracetamol 125 mg
excipients: microcrystalline cellulose 20 mg, corn starch 59.04 mg, lactose 5 mg, sodium carboxymethyl starch (type A) 30 mg, crimson dye (Ponceau 4R) (E124) 0.2 mg, glycerol 2 mg, colloidal silicon dioxide 5 mg, orange flavor DC 100 pH 1.6 mg, pineapple flavor DC 106 pH 2.5 mg, peppermint leaf oil 0.66 mg, aspartame 10 mg, magnesium stearate 1 mg, talc 3 mg.
Description. The tablets are flat-cylindrical in shape, pink in color interspersed with a chamfer and a score on one side and have a fruity-mint odor.
Pharmacological properties:
Pharmacodynamics. A combined drug whose effect is determined by its constituent components.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic effects. By inhibiting cycloxygenase (COX) 1 and 2, it disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins (mediators of pain, inflammation and hyperthermic reaction), both in the site of inflammation and in healthy tissues, suppresses the exudative and proliferative phases of inflammation.
Paracetamol - indiscriminately blocks COX, mainly in the central nervous system, has little effect on water-salt metabolism and the mucous membrane of the gastrointestinal tract (GIT). Has an analgesic and antipyretic effect. In inflamed tissues, peroxidases neutralize the effect of paracetamol on COX 1 and 2, which explains the low anti-inflammatory effect.
The effectiveness of the combination is higher than that of individual components.
Pharmacokinetics. Ibuprofen.
Absorption is high, quickly and almost completely absorbed from the gastrointestinal tract (GIT). The time to reach maximum concentration (TCmax) after oral administration is about 1-2 hours. Communication with blood plasma proteins is more than 90%. The half-life (T1/2) is about 2 hours. It slowly penetrates into the joint cavity, accumulates in the synovial fluid, creating higher concentrations in it than in the blood plasma. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. Metabolized. More than 90% is excreted by the kidneys (no more than 1% unchanged) and, to a lesser extent, with bile in the form of metabolites and their conjugates.
Paracetamol.
Absorption is high, binding to plasma proteins is less than 10% and increases slightly with overdose. Sulfate and glucuronide metabolites do not bind to plasma proteins even at relatively high concentrations. The Cmax value is 5-20 μg/ml, TCmax is 0.5-2 hours. Distributed fairly evenly in body fluids. Penetrates the blood-brain barrier.
About 90-95% of paracetamol is metabolized in the liver to form inactive conjugates with glucuronic acid (60%), taurine (35%) and cysteine (3%), as well as small amounts of hydroxylated and deacetylated metabolites. A small portion of the drug is hydroxylated by microsomal enzymes to form highly active N-acetyl-n-benzoquinone imine, which binds to the sulfhydryl groups of glutathione. When glutathione reserves in the liver are depleted (in case of overdose), the enzyme systems of hepatocytes can be blocked, leading to their development.
T1/2 - 2-3 hours. Excreted by the kidneys, mainly in the form of glucuronide and sulfate conjugates (less than 5% - unchanged). Less than 1% of the administered dose of paracetamol passes into breast milk. In children, the ability to form conjugates with glucuronic acid is lower than in adults.
Indications for use:
Feverish syndrome.
Pain syndrome of weak or moderate intensity of various etiologies: pain with sprains, dislocations, fractures.
As an auxiliary drug for the treatment of pain and fever in sinusitis, tonsillitis, acute infectious and inflammatory diseases of the upper sections respiratory tract(pharyngitis,).
Important! Get to know the treatment
Directions for use and dosage:
The drug is taken orally. Before use, the Ibuklin® tablet should be dissolved in 5 ml (1 teaspoon) of water. Daily dose The drug is taken in 2-3 doses. The minimum time interval between taking the drug is 4 hours.
Children over 3 years old.
Single dose- 1 tablet. The daily dose depends on the age and weight of the child: 3-6 years (13-20 kg) - 3 tablets per day; 6-12 years (20-40 kg) - up to 6 tablets per day.
In case of impaired renal or liver function, the interval between doses of the drug should be at least 8 hours.
The drug should not be taken for more than 5 days as an analgesic and for more than 3 days as an antipyretic without medical supervision.
Precautions for use
Chronic heart failure, cerebrovascular diseases, dyslipidemia/hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, creatinine clearance less than 60 ml/min, history of ulcerative lesions of the gastrointestinal tract, infection Helicobacter pylori, long-term use of NSAIDs, alcoholism, severe somatic diseases, simultaneous use of oral glucocorticosteroids (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors ( including citalopram, fluoxetine, paroxetine, sertraline).
Use during pregnancy and lactation
If it is necessary to use the drug Ibuklin® during pregnancy and lactation (breastfeeding), you should carefully weigh the expected benefits of therapy for the mother and the potential risk to the fetus or child.
If use is necessary, long-term use of the drug Ibuklin® should be avoided in the first trimester of pregnancy.
If short-term use of the drug Ibuklin® is necessary during lactation, cessation of breastfeeding is usually not required.
Experimental studies have not established the embryotoxic, teratogenic and mutagenic effects of the components of the drug Ibuklin.
Features of application:
The advisability of using the drug as an antipyretic is decided in each case, depending on the severity, nature and tolerability of the febrile syndrome.
Ibuprofen may mask objective signs of infectious diseases, so ibuprofen therapy in patients with infectious diseases should be prescribed with caution.
To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used for the shortest possible short course.
With the simultaneous use of indirect anticoagulants, it is necessary to monitor the indicators of the blood coagulation system.
Co-administration of Ibuklin® with other NSAIDs should be avoided.
With long-term (more than 5 days) use of the drug, monitoring of peripheral blood and the functional state of the liver is necessary.
The drug may distort the results of laboratory tests when quantitatively determining glucose, uric acid in blood serum, and 17-ketosteroids (the drug must be discontinued 48 hours before the test).
Impact on the ability to drive vehicles and machinery
During the treatment period, the patient should refrain from engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions.
Side effects:
In therapeutic doses, the drug is usually well tolerated.
From the outside digestive system: rarely - dyspeptic effects, with long-term use in high doses - hepatotoxic effect.
From the hematopoietic system: rarely - pancytopenia, .
Allergic reactions: rarely -, itching,.
When side effects you should stop taking the drug and consult a doctor.
Interaction with other drugs:
With the simultaneous use of the drug Ibuklin® with drugs, the development of various effects interactions.
Long-term combined use with paracetamol increases the risk of nephrotoxic effects.
Combination with ethanol, glucocorticosteroids, corticotropin increases the risk of erosive and ulcerative lesions of the gastrointestinal tract.
Ibuprofen enhances the effect of direct (heparin) and indirect (coumarin and indanedione derivatives) anticoagulants, thrombolytic agents (alteplase, anistreplase, streptokinase, urokinase), antiplatelet agents, colchicine - the risk of developing hemorrhagic complications increases.
Enhances the hypoglycemic effect of insulin and oral hypoglycemic drugs.
Weakens the effects of antihypertensive drugs and diuretics (by inhibiting the synthesis of renal prostaglandins).
Increases the blood concentration of digoxin, lithium and methotrexate.
Caffeine enhances the analgesic effect of ibuprofen.
Cyclosporine and gold preparations increase nephrotoxicity.
Cefamandole, cefoperazone, cefotetan, valproic acid, plicamycin increase the incidence of hypoprothrombinemia.
Antacids and cholestyramine reduce the absorption of the drug.
Myelotoxic drugs contribute to the manifestation of hematotoxicity of the drug.
Contraindications:
Increased individual sensitivity to the components of the drug (including other NSAIDs), and the duodenum in the acute phase, complete or incomplete combination of recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history), severe (creatinine clearance less than 30 ml/min), damage to the optic nerve, genetic absence of glucose-6-phosphate dehydrogenase, diseases of the blood system, postoperative period, progressive kidney disease, severe or active liver disease, confirmed, active, inflammatory bowel disease, childhood (up to 3 years).
Forced diuresis; activated carbon orally, administration of SH-group donors and precursors for the synthesis of glutathione - methionine 8-9 hours after an overdose and N-acetylcysteine orally or intravenously - after 12 hours, antacid drugs; ; symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, intravenous administration N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.
Storage conditions:
In a dry place, protected from light and out of reach of children, at a temperature not exceeding 25°C. Shelf life: 5 years. Do not use after the expiration date stated on the packaging.
Vacation conditions:
On prescription
Package:
Dispersible tablets [for children] 100 mg + 125 mg. 10 tablets in a PVC/A1 blister. 1, 2 or 20 blisters are packed in a cardboard box along with instructions for use and a spoon for preparing the suspension.
The pharmacy sells many combination drugs, which can be purchased without a doctor's prescription. One of the effective ones is Ibuklin. The medicine is very popular because it has a triple effect due to the interaction of two main components - ibuprofen and paracetamol. Find out how to take Ibuklin for maximum benefit.
Ibuklin - indications for use
When prescribing medicine, doctors use an individual approach to each patient, because the medicine has significant contraindications. The drug is often prescribed to patients suffering from feverish colds and flu. At correct use the drug has an analgesic, anti-inflammatory and antipyretic effect. It is effective for inflammatory diseases of the musculoskeletal system, menstruation, and tendovaginitis. Otherindications for use of Ibuklin according to the instructions:
- myalgia;
- toothache, headache;
- gouty arthritis, psoriatic arthritis;
- post-traumatic pain syndromes;
- bursitis;
- painful sensations with osteochondrosis of the spine;
- soft tissue bruises, stretch marks, dislocations;
- adnexitis;
- deforming osteoarthritis;
- pharyngitis, otitis and other diseases of the ENT organs.
Ibuklin - composition
The drug has a multifaceted positive effect due to the contents it contains. active substances. These are Ibuprofen and Paracetamol. Both substances are equally effective, perfectly complement each other’s action and have good compatibility when used. According to the instructions, Ibuprofen is absorbed into the blood and stops the production of prostaglandins, pain mediators, reduces inflammation, and has an antipyretic effect.
Paracetamol begins to act even faster than the previous substance. It has a moderate anti-inflammatory effect, blocks COX, provides excellent pain relief, and relieves fever and swelling of the joints. In combination with Ibuprofen it is more effective than alone. INcomposition of IbuklinaThere are also excipients: lactose, corn starch, glyceryl, colloidal silicon dioxide and others.
Ibuklin - instructions
The drug does not delay the progression of the disease, but is effective for symptomatic therapy. Anyone who intends to use this medicine should be aware of this property. medicinal purposes. Definitely worth checking outIbuklin's instructions, pharmacology, contraindications. In addition, it is important to study the dosage and rules of use for adults and children.
Ibuklin Junior
Available for the treatment of young patients children's version with the name Ibuklin Junior. The packaging is similar to the adult one, the composition is similar, but it contains lower content of active ingredients. For example, one Junior tablet contains 100 mg of ibuprofen and 125 mg of paracetamol. To improve the taste, pineapple and orange flavors have been added.Ibuklin for childrenprescribed to children over 2 years of age. The instructions indicate the exact dosage depending on the weight and age of the baby. According to instructions medicinal product effective:
- at infectious diseases;
- for degenerative diseases of the musculoskeletal system;
- elevated temperature bodies;
- ruptures, sprains;
- burns;
- sore throat.
Ibuklin for adults
The medicine is available in the form of capsules with a noticeable, orange shell.Ibuklin for adultsrecommended for use for symptomatic treatment, it does not affect the underlying disease. Helps in following cases:
- toothache;
- sciatica;
- rheumatoid arthritis;
- chronic arthritis;
- for diseases of periarticular tissues;
- ankylosing spondylitis;
- fractures, dislocations;
- juvenile arthritis;
- pain syndrome after operation;
- painful periods in women;
- fever that is not controlled by other single-component drugs;
- tracheitis, otitis.
Ibuklin during pregnancy
Tablets are rarely used to treat pregnant women. One-time use is acceptable, but regular use is strictly prohibited. In exceptional cases, tablets can be prescribed in the first and second trimesters. After 30 weeks, the drug increases the risk of developing kidney pathology in the fetus. If a woman needs an anti-inflammatory, antipyretic drug, it is better to use safer Paracetamol.Ibuklin during breastfeedingLet's say after consulting a doctor. You should drink it after feeding.
Ibuklin - contraindications
Ibuklina's abstract contains full list possible side effects and a list of contraindications. Reception should be suspended if the patient develops a skin rash, itching, leukopenia, or agranulocytosis.Contraindications for Ibuklin:
- blood diseases;
- stomach ulcer during exacerbation;
- hypersensitivity to components;
- bronchial asthma;
- liver diseases;
- renal failure;
- cardiovascular diseases;
- recurrent polyposis of the nose and sinuses;
- inflammation in the intestines;
- taking other NSAIDs;
- damage to the optic nerve.
It is difficult to find words to describe the happiness of motherhood; it is even more difficult to describe the experiences and fears experienced by a mother when her baby is sick.
The first fever, the first flu and cold - all this is difficult and painful, but you can’t give up, just as you can’t panic, because the main thing is to make the baby feel better. Every mother has her own first aid kit. How to supplement it?
We will tell you about children's Ibuklin in tablets and its instructions for use, whether it is prescribed for fever, what the price is and reviews of this drug for children. Pediatricians often prescribe it, so we will reveal all the positive and negative characteristics medicines.
Composition, active ingredients, description, release forms
Ibuklina includes 2 active ingredients A: paracetamol and ibuprofen, the latter performs the following functions:
- painkiller;
- anti-inflammatory;
- antipyretic.
By analogy with Ibuprofen, Paracetamol has an analgesic effect, but has a stronger antipyretic effect.
The ratio of these substances% in medicines for adults and children is very different.
From the table it follows that the total weight of active ingredients in the medicine for adults is 725 mg (325 + 400), with the proportion of Ibuprofen slightly higher than Paracetamol.
And, on the contrary, in children's medicine, containing 225 mg of active substance (125 + 100), the proportion of Paracetamol is a quarter higher than Ibuprofen.
Medicines for adults and children differ in appearance. Children's tablets are made in pink color , they are highly soluble in water and have a fruity-mint smell.
Adult tablets are orange in color, coated, have poor solubility (after all, adults swallow them whole).
In all cases, tablets are the only form of drug release. One blister contains 10 pieces, the number of blisters in a package can be 1, 2 or 20.
In addition to the active ingredients, the medicine contains auxiliary ingredients:
Indications for use for children
The medicine has analgesic, anti-inflammatory and antipyretic properties.
This feature allows mothers to make their babies feel better when:
Ibuklin can be given to children when teething., if it is very painful and painful (c).
Contraindications
For some diseases, taking the medicine is prohibited:
- damage to the digestive system (gastrointestinal bleeding, exacerbation of duodenal and gastric ulcers, inflammation of the intestines, liver failure);
- diseases of the blood system;
- hyperkalemia;
- renal failure;
- intolerance to acetylsalicylic acid in combination with;
- individual intolerance to substances (active or auxiliary) of the drug;
- damage to the optic nerve.
How the drug works
We already know in what cases Ibuklin can be used. Which mechanism of its action? The human body contains enzymes - cyclooxygenases 1 and 2 (COX-1, COX-2).
The result of their final work is the synthesis of mediators of inflammation, pain and an increase in body temperature. suppresses the activity of COX-1, COX-2, causing the synthesis of mediators to slow down.
Subjectively, children perceive the result of ibuprofen as relief from a painful condition.
, part of Ibuklin, has a weak effect on the work of COX-1 and COX-2, so its purpose is to provide an analgesic effect and normalize body temperature by affecting the thermoregulation center in the hypothalamus.
Ibuprofen reaches its maximum effect after 2 hours after taking it, while Paracetamol begins to work 10 minutes after taking the medicine, and its strongest result appears after an hour.
These substances are excreted from the body in feces (Paracetamol) and urine (Ibuprofen).
Dosage at different ages
The first thing you need to pay attention to: under the age of 12 years only children's Ibuklin is used. The dosage of the drug is determined based on body weight.
This information is reflected in the table.
Children over 12 years of age and weighing more than 40 kg receive the minimum adult dose.
special instructions
Instructions for use of Ibuklin tablets for children: tablet dissolves in 5 ml boiled water room temperature. The course of taking the drug to reduce fever should not exceed 3 days, and for pain relief – 5 days.
Some caution should be taken when giving medicine to children With diabetes mellitus And nephrotic syndrome, as well as taking hormonal medications.
If your child is taking blood thinners, taking Ibuklin is a mandatory reason to control its clotting.
Interaction with other substances
Ibuklin reduces the effect of drugs aimed at lowering blood pressure and medications that have a diuretic effect.
Taking the drug leads to an increase in the concentration of digoxin and drugs (methotrexate, lithium) in the blood.
The analgesic effect of the drug increases when taking caffeine.
When taking cyclosporine simultaneously, nephrotoxicity occurs, the same happens when taking gold preparations.
Absorption of the drug is reduced when taking Cholestyramine and antacids simultaneously.
Ibuklin reduces the anti-inflammatory value of acetylsalicylic acid.
When combined with corticotropin, ethanol and corticosteroids (used to treat ankylosing spondylitis), gastrointestinal ulcers may occur or worsen.
Combination with myelotoxic drugs leads to hematotoxicity.
Overdose and side effects
Systematization undesirable consequences- in the table.
At the slightest suspicion of an overdose, you should immediately call a doctor.. Any therapeutic measures are determined by the symptoms of disturbances in the functioning of the body.
First aid for overdose is gastric lavage, then activated charcoal and alkaline drinking are used.
Average prices in Russia
Prices for Ibuklin for children(20 pieces per package) - 75-120 rubles. Most often, the medicine is produced in India.
Storage and release conditions, shelf life
Shelf life of the drug – 5 years, it should be stored in a dark, dry place, temperature regime– no higher than 25 °C.
