Active substance
Drotaverine hydrochloride (drotaverine)
Release form, composition and packaging
◊ Pills yellow with a greenish tint, round, flat-cylindrical in shape, with a chamfer and a notch.
Excipients: potato starch - 30.1 mg, lactose monohydrate (milk sugar) - 60.1 mg, (polyvinylpyrrolidone) - 5.8 mg, talc - 2.6 mg, magnesium stearate - 1.4 mg.
10 pieces. - contour cellular packaging (1) - cardboard packs.
10 pieces. - contour cell packaging (2) - cardboard packs.
10 pieces. - contour cell packaging (3) - cardboard packs.
10 pieces. - contour cell packaging (4) - cardboard packs.
10 pieces. - contour cell packaging (5) - cardboard packs.
100 pieces. - polymer jars (1) - cardboard packs.
pharmachologic effect
Myotropic antispasmodic, isoquinoline derivative. Inhibits phosphodiesterase (PDE) IV, which leads to the accumulation of intracellular cyclic adenosine monophosphate (cAMP) and, as a result, inactivation of the light chain of myosin kinase, resulting in relaxation of smooth muscles.
Regardless of the type of autonomic innervation, drotaverine acts on smooth muscles in the gastrointestinal tract, biliary, genitourinary and vascular systems Oh. In the myocardium and blood vessels, the enzyme that hydrolyzes cAMP is PDE III, which explains the absence of serious side effects from the outside of cardio-vascular system(SSS) and unexpressed therapeutic effect in relation to the SSS.
The presence of a direct effect on smooth muscles allows its use as an antispasmodic in cases where drugs from the group of m-anticholinergics are contraindicated (angle-closure glaucoma, hyperplasia prostate gland).
Pharmacokinetics
When taken orally, absorption is high, half-life is 12 minutes. Bioavailability – 100%. Evenly distributed in tissues, penetrates smooth muscle cells. The time to reach Cmax in the blood is 2 hours. Protein binding is 95-98%. It is mainly excreted by the kidneys, and to a lesser extent – with bile. Does not penetrate the blood-brain barrier.
Indications
- spasm of smooth muscles of the urinary and biliary organs ( renal colic, pyelitis, tenesmus, biliary colic, intestinal colic, dyskinesia of the biliary tract and gallbladder of the hyperkinetic type, cholecystitis, postcholecystectomy syndrome);
- spasm of smooth muscles of the gastrointestinal tract (as a rule, as part of combination therapy): pylorospasm, gastroduodenitis, peptic ulcer stomach and duodenum, spastic constipation, spastic colitis, proctitis;
- tensor headache;
- dysmenorrhea, threatened miscarriage, threatened premature birth, postpartum contractions;
- when carrying out some instrumental studies, cholecystography.
Contraindications
- pronounced hepatic and renal failure;
- severe deficiency (low cardiac output);
- lactation period;
— increased sensitivity to the components of the drug.
This dosage form is not used in children under 3 years of age.
Due to the presence of lactose monohydrate (milk sugar) in the drug, its use is contraindicated in cases of congenital lactose intolerance, lactase deficiency, and glucose-galactose malabsorption.
Drotaverine should be taken with caution used for arterial hypotension, severe atherosclerosis coronary arteries, prostatic hyperplasia, angle-closure glaucoma, during pregnancy.
Dosage
For adults prescribed orally 40-80 mg (1-2 tablets) 2-3 times/day. Maximum daily dose– 240 mg.
Children aged 3 to 6 years- in a single dose of 20 mg, maximum daily dose – 120 mg (in 2-3 doses); V age from 6 to 12 years single dose – 40 mg, maximum daily dose – 200 mg; frequency of use – 2-5 times/day.
Side effects
Dizziness, headache, insomnia, palpitations, decreased blood pressure, allergic reactions, nausea, constipation, feeling hot, sweating.
Overdose
There is no data on overdose regarding the drug.
Drug interactions
When used simultaneously, the antiparkinsonian effect of levodopa may be weakened.
Enhances the effect of bendazole and other antispasmodics (including m-anticholinergics), the decrease in blood pressure caused by tricyclic antidepressants, quinidine and procainamide.
Reduces the spasmogenic activity of morphine.
Increases the severity of the antispasmodic effect of drotaverine.
special instructions
In the treatment of gastric and duodenal ulcers, it is used in combination with other drugs usually prescribed for the treatment of this group of diseases of the esophagus, stomach and duodenum.
Impact on the ability to drive vehicles and operate machinery
When taken orally in therapeutic doses, drotaverine does not affect the ability to drive a car or perform work that requires increased attention. If any side effects occur, the issue of driving vehicles and operating machines requires individual consideration.
Instructions for use of the drug Drotaverine allow you to obtain information about the properties of this medicine, read the description, find out what the drug helps with and for what conditions it is used, and also find out what its mechanism of action is in the human body. Drotaverine is approved for adults and children over a certain age; the main thing is to follow the age-appropriate dosage when the medicine is prescribed.
Composition and release form
Drotaverine is available in two forms:
- ampoules (injection solutions);
- pills.
The active ingredient is drotaverine hydrochloride. Each of the forms is absolutely identical in the amount of active ingredient - 40 mg contains one tablet and ampoule.
Drotaverine is produced by many pharmaceutical companies, the purpose and use of which do not affect the quality of the drug itself, simply indicate a difference in the company of release.
That’s why Drotaverine has many names:
- Drotaverine - Teva;
- Drotaverine - Ellara;
- Drotaverine – Forte;
- Drotaverine – FPO;
- Vero - Drotaverine.
When buying Drotaverine from Darnitsa or any other, you should not worry about the quality of the product, since in all companies it is selected and has the same qualities, so domestic or even foreign packaging will contain the same drug, which does not differ from each other.
One of the main causes of constipation and diarrhea is use various medications . To improve bowel function after taking medications, you need to do it every day. drink a simple remedy ...
Indications for use
Drotaverine is a drug that is an antispasmodic, due to which it helps with pain in the head, abdomen, stomach, intestines, it also dilates blood vessels and allows you to reduce blood pressure, and therefore is an excellent antihypertensive agent.
Therefore, Drotaverine can be prescribed to an adult or child with the following symptoms and diseases:
- Expressed pain syndrome during menstruation.
- Pain in the abdomen (stomach, intestines, uterus) caused by spasm of smooth muscles.
- Diseases of the urinary system (cystitis, urolithiasis, pyelitis, etc.).
- Diseases of the liver and gall bladder (hepatic colic, cholangitis, cholecystitis, papillitis and much more).
- The need to relax smooth muscles in women - with increased tone uterus before labor begins ahead of schedule to prevent miscarriage and premature birth of a child.
- Spasms blood vessels to relieve headaches.
- Diseases of the digestive tract (gastritis, stomach ulcers, irritable bowel syndrome, spastic colitis and constipation, enteritis, proctitis, etc.).
- Hypertension to lower blood pressure.
The drug Drotaverit can be taken in tablets and ampoules. It is important how to take the medicine - before or after meals. The tablets are taken immediately after meals, even after a small snack you can take the medicine. These tablets should not be chewed, only swallowed with water. It doesn’t matter how you take the injections in relation to food. Ampoules can be administered intramuscularly, intravenously, subcutaneously and intraarterially.
For intravenous and intra-arterial administration, Drotaverine should be diluted with 20 mg of physiological solution; for other injections, a regular solution of Drotaverine is suitable. The injections must be given by a specialist.
Drotaverine can be taken by adults (even pregnant women) in the following dosage:
- Pills– one or two tablets are taken no more than 3 times per day. An adult can be given no more than 240 mg per day, which corresponds to six tablets.
- Injections– one or two ampoules 1-3 times during one day, but the daily dose should not exceed six ampoules.
For children, the dosage of the drug is different and depends on the age of the child:
Pills:
- from 3 years to 6 years – a quarter or half of a Drotaverine tablet is prescribed 2-3 times a day. The daily dose is no more than three tablets.
- from 6 to 12 years – half or whole tablet prescribed for use 2 to 5 times a day. The daily dose of the drug should not be more than 5 tablets.
Injections:
- from 3 years to 6 years – 10-20 mg of Drotaverine 1-3 times a day, but not more than 120 mg of the drug per day.
- from 6 to 12 years – 20 mg 1-3 times a day, but not more than 200 mg per day.
How much medication can be given to a child in a particular case must be decided by the doctor; the same applies to taking the drug by adults.
It is better not to exceed the specified dosage to avoid side effects and harm to the body.
How long does it take to work?
Drotaverine tablets begin to act on the body within half an hour after administration. The injections take effect much faster - 2-3 minutes.
Therefore, the properties of the drug allow it to quickly relieve spasms in certain cases that require immediate attention, such as premature birth.
Pregnancy and breastfeeding
During pregnancy and lactation, Drotaverine can be used by women without fear of harming the fetus. When breastfeeding, the drug is not excreted in milk.
Drotaverine is well suited for pregnant women at any stage and is not able to reduce the muscle activity of the uterus at the time of childbirth if the drug has been taken previously (a week or more), but it will help relieve pelvic pain.
Alcohol compatibility
Drotaverine and alcohol do not affect each other - alcohol does not reduce the effect of the drug, and Drotaverine does not increase the toxic effect of alcohol.
Contraindications
- atrioventricular block I-III degree;
- intolerance to the components of the drug;
- hypotension;
- cardiogenic shock;
- lactase deficiency.
Side effects
The drug can cause a number of side effects on the human body in certain cases:
- dizziness;
- nausea;
- insomnia;
- feeling of heat;
- sweating;
- increased heart rate;
- decreased blood pressure;
- collapse;
- anaphylactic shock.
Overdose
In case of an overdose of the drug, paralysis of the respiratory center and cardiac arrest are possible. It is necessary to immediately stop taking the drug, drink sorbents and begin symptomatic therapy to maintain vital functions.
Drotaverine and No-shpa: what is the difference?
Drotaverine and No-shpa are considered analogues not only in composition, but also in their mode of action on the body. Their differences are shown in the table.
| No-shpa | ||
|---|---|---|
| Active substance | Drotaverine hydrochloride is ordered from warehouses Far East, where the quality of processing is worse | More high quality processing drotaverine hydrochloride, a purer drug is obtained |
| Release form | Tablets and injections for intravenous, intramuscular and subcutaneous administration 40 mg of the drug | Tablets and injections for intravenous and intramuscular injection 40 and 80 mg of the drug |
| Age of application | From three years tablets and from 1 year injections | From six years old |
| Use during lactation | Allowed | Not recommended |
| Price | 10-130 rub. | 50-205 rub. |
No-spa as a substitute for Drotaverine is quite suitable in its qualities and is sometimes even more effective. But that's only for certain people, and Drotaverine has even more advantages both in price and in the possibility of use.
What does drotaverine, an effective and often prescribed drug with an antispasmodic effect, help with? It has a beneficial effect on smooth muscle tissue various systems body, eliminating spasms and painful sensations both nervous and muscular etiology.
No serious side effects were noted, but the use medicine should be carried out exclusively by a doctor and taken by the patient under the supervision of a specialist.
Drotaverine: composition and pharmacological action
The drug is available in two dosage forms is a solution for intramuscular injections and tablets. The first includes:
- main component – drotaverine hydrochloride;
- additional substances.
- drotaverine hydrochloride;
- lactose;
- additional components.
The drug is prescribed in tablet form more often than in injections.
After taking the drug, the active substance, which has antispasmodic activity, begins to affect the smooth muscles that are located in the genitourinary, biliary, cardiovascular and gastrointestinal systems. It significantly dilates the blood vessels, as a result of which oxygen begins to flow freely to the tissues and relieves spastic pain.
The components of the drug are capable of changing the permeability and potential of membranes in the tissue in a short period of time. They also reduce the activity of phosphodiesterase, a special enzyme.
After taking the tablet the concentration active substance will reach its concentration in 50-60 minutes. Excreted from the body in urine, a small amount may be excreted in feces.
At the same time, the drug Drotaverine does not have any serious side effects in relation to the cardiovascular system, comparing favorably in this regard with many of its analogues. It is a drug with antispasmodic, vasodilating, myotropic and hypotensive effects.
Indications for use
Why Drotaverine can be prescribed by a therapist - the specialist must exclude individual intolerance to the components of the drug. The main indication for its use is to relieve a person of spastic pain that can occur with a variety of ailments. The drug may be prescribed if one of the following diseases has been diagnosed:
- frequent spasms with cholecystitis;
- stomach or duodenal ulcer;
- constipation, accompanied by spasms of smooth tissues that cause severe pain;
- colic due to gas retention;
- urethritis and cystitis;
- proctitis with pronounced pain;
- urethrolithiasis, pyelitis, nephrolithiasis - for these diseases, Drotaverine is prescribed as a local anesthetic drug, and it is part of a complex of medications.
Along with this, a medicine such as Drotaverine can be recommended for use when diagnostic activities. For example, with cholecystography or similar.
Elimination of spasms is the main task of Drotaverine
Because the drug has a vasodilating effect, health care providers often prescribe it to relieve severe headaches that occur when cerebral vasospasms occur.
The use of Drotaverine in gynecology is widespread - it can help with spasms of the uterine pharynx or with prolonged dilatation. It is also prescribed for emergency childbirth if the specialist notes the risk of uterine spasms during the passage of the fetus.
Taking Drotaverine
The tablets are taken orally and should be taken with plenty of water. The frequency of meals, as a rule, does not have any effect, so there is not much difference in taking Drotaverine before or after meals. You can even do it on an empty stomach if a person suffers from severe pain or colic. The only inconvenience in this case is that the impact on the source of discomfort may begin a little later.
If the patient suffers too much strong pain, which you have no strength to endure, the doctor may prescribe injections. They act much faster because they are administered intramuscularly. However, there are exceptions for patients with hepatic or renal colic - in them the drug is administered intravenously (slowly and in small portions). At the same time, there is a small risk of collapse (decreased blood supply to tissues, resulting in dysfunction of certain organs), so such procedures should be carried out exclusively in a supine state.
Important: it is prohibited to independently determine the duration of the course; only a specialist can choose how to take Drotaverine.
In particular in case of emergency When vasospasm occurs and peripheral circulation is disrupted, Drotaverine can even be injected into an artery. The dosage must be carefully calculated by the doctor, and the drug should be administered even more slowly than intravenously.
Important: since the procedure is emergency, it should only be performed by a specialist. He will be able to stop possible consequences(although, as a rule, with proper actions medical worker they do not appear).
Compatibility of the drug with other drugs
If you use Drotaverine for the abdomen or in other cases in combination with other drugs that also have an antispasmodic effect, the effect of treatment may be enhanced, but such therapy should be carried out exclusively with the approval of the attending physician. Only a specialist will recommend medications that not only do not cancel therapeutic effect Drotaverine, but can also make it more pronounced.
If you combine Drotaverine with tricyclic antidepressants, you should be prepared for the fact that arterial hypotension may increase many times over.
Patients who have been prescribed morphine should use Drotaverine with caution, as this drug greatly reduces the spasmogenic effect.
Overdose of Drotaverine
It is strictly forbidden to change the dosage prescribed by your doctor. An increase in the number of tablets or injections can provoke the development of atrioventricular block and lead to paralysis of the respiratory nerve, and the consequences of this can be extremely negative.
Possible side effects
Side effects from taking Drotaverine can occur in two cases: if it is taken for too long or if allergic reaction to any component. Such actions include the following manifestations:
- gastrointestinal tract - belching, constipation (or vice versa diarrhea), feeling of nausea, vomiting;
- central nervous system – fainting, severe headaches, disrupted daily routine, sleep disturbances;
- respiratory tract – swelling of the mucous membranes or bronchospasms;
- allergic reactions - Quincke's edema, dermatitis, rash, excessive sweating, itching;
All the described effects occur both when taking tablets and after injections, however, in the latter case, the patient may begin to develop depressed breathing, hypotension, or atrioventricular block (impaired conduction of electrical impulses from the atria to the ventricles).
It is important to follow the dosage of the drug, otherwise side effects may occur.
If you have headaches while taking Drotaverine or one of these side effects has been noted, and especially after injections, then the course of treatment should be stopped and you should consult your doctor. He will be able to either select analogues or prescribe additional medications to eliminate these actions.
Use during pregnancy and lactation
Drotaverine hydrochloride, the active substance, is able to penetrate the hematoplacental barrier. In other words, this component of the drug can have a direct effect on the fetus and in one way or another influence its development. A specialist may prescribe medication if the hypothetical benefit for the pregnant woman is higher than the potential threat to the child.
During breastfeeding You should stop taking Drotaverine, since it passes into mother's milk and, accordingly, is passed on to the baby. If refusal is impossible, then you need to think about temporarily stopping breastfeeding and transferring the child to artificial formula.
Often, medicine can be prescribed during premature birth, to relieve the tone of the uterus (this will stabilize the condition if there is a threat of miscarriage and will help promptly and without harm to the mother’s health to begin all the necessary auxiliary actions), as well as in the period after childbirth to stop contractions.
Whether Drotaverine can be prescribed to children is an open question. Some pediatricians and therapists are against therapy using this medicine and strongly recommend using it only after reaching 12 years of age, while others believe that the drug will not cause harm and prescribe it from 5-6 years of age. In any case, the treatment process with this medicine should be under the constant supervision of the attending physician.
Contraindications for use
As a rule, almost all medicines have certain contraindications, and Drotaverine is no exception. It should be used only after reading the instructions and according to the prescribed course of treatment. Contraindications are identical regardless of which form of the drug was chosen. These include:
- heart failure;
- cardiogenic shock;
- low blood pressure;
- atrioventricular block II or III degree;
- renal or liver failure;
- congenital lactase deficiency;
- malabsorption.
The drug is prescribed with caution to those diagnosed with atherosclerosis of the coronary arteries, the same applies to the usual form of atherosclerosis. It is not recommended for people whose professional activity associated with increased concentration. If, nevertheless, taking Drotaverine is necessary, then after it you should avoid activities that require increased attention and concentration for 2-3 hours.
Gross formula
C24H31NO4Pharmacological group of the substance Drotaverine
Nosological classification (ICD-10)
CAS Code
14009-24-6Characteristics of the substance Drotaverine
Light yellow crystalline powder, odorless. Soluble in water and alcohol.
Pharmacology
pharmachologic effect- vasodilator, antispasmodic, myotropic, hypotensive.Reduces the intake of ionized active calcium into smooth muscle cells through inhibition of phosphodiesterase and intracellular accumulation of cAMP. Quickly and completely absorbed into the gastrointestinal tract. When taken orally, bioavailability is close to 100%, and the half-absorption period is 12 minutes. It is evenly distributed throughout the tissues and penetrates smooth muscle cells. Excreted by the kidneys.
Pronounced and long-lasting expansion of smooth muscles internal organs and blood vessels, lowers blood pressure, increases cardiac output. Virtually no effect on vegetative nervous system and does not penetrate the central nervous system.
Application of the substance Drotaverine
Spasm of smooth muscles of internal organs (cardio- and pylorospasm), chronic gastroduodenitis, peptic ulcer of the stomach and duodenum, cholelithiasis(hepatic colic), chronic cholecystitis, postcholecystectomy syndrome, hypermotor dyskinesia biliary tract, spastic intestinal dyskinesia, intestinal colic due to gas retention after surgery, colitis, proctitis, tenesmus, flatulence, urolithiasis disease(renal colic), pyelitis, spasm of cerebral vessels, coronary and peripheral arteries, the need to weaken uterine contractions and relieve cervical spasm during childbirth, spasm of smooth muscles during instrumental interventions.
Contraindications
Hypersensitivity, glaucoma.
Restrictions on use
Prostate adenoma, severe atherosclerosis of the coronary arteries.
Use during pregnancy and breastfeeding
Side effects of the substance Drotaverine
Feeling of heat, dizziness, arrhythmias, hypotension, palpitations, sweating (more often with parenteral administration), allergic dermatitis.
Interaction
Strengthens (especially with intravenous administration) the effect of other antispasmodics (including m-anticholinergics), hypotension caused by tricyclic antidepressants, quinidine, novocainamide. Phenobarbital increases the reliability of eliminating spasms. Reduces the spasmogenic activity of morphine and the antiparkinsonian properties of levodopa.
Overdose
AV block, cardiac arrest, paralysis of the respiratory center.
Routes of administration
Inside, intramuscularly, subcutaneously.
Interactions with other active ingredients
Trade names
| Name | The value of the Vyshkowski Index ® |
| 0.3402 | |
| 0.0181 | |
| 0.0097 | |
| 0.0029 | |
| 0.0021 | |
| 0.0021 | |
| 0.0019 | |
| 0.0009 | |
| 0.0009 | |
| 0.0008 | |
(lat. drotaverine) - a vasodilator, antihypertensive drug, myotropic antispasmodic.
Chemical compound : (1-(3,4-diethoxyphenyl) methylene-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline (as hydrochloride). Empirical formula C 24 H 31 NO 4.
Drotaverine - international generic name(INN) of the drug. According to the pharmacological index, drotaverine belongs to the groups “Vasodilators” and “Myotropic antispasmodics”. According to ATC, it belongs to the group “A03A Preparations for the treatment of functional intestinal disorders”, subgroup “A03AD Papaverine and its derivatives” and has the code A03AD02. 
, in addition, the trade name of a medicine produced in the form of tablets and solution for injection.
Composition of the drug drotaverine
- One tablet of drotaverine contains 40 mg active substance- drotaverine hydrochloride, as well as Excipients: lactose, potato starch, povidone, talc, magnesium stearate. Manufacturers: ALSI Pharma, Veropharm, Moskhimfarmpreparaty, Biokhimik, Obolenskoye - pharmaceutical company, Valenta Pharmaceuticals, Rozfarm, Antiviral, Synthesis ACO, Pharmproject, Biosynthesis, Dalkhimpharm, Moscow endocrine plant, Tatkhimfarmpreparaty, Organika, Nizhpharm, PFC Update, Artlife, SSC NIOPIK, Europharm and others (Russia), Borisov ZMP (Belarus).
- The content of drotaverine hydrochloride in the solution for injection "drotaverine" is 20 mg/ml. Manufacturers: Novosibkhimpharm, Dalkhimfarm, Norbiofarm, JSC Biomed im. I.I. Mechnikova, Deco, VIFITECH (Russia).
Pharmacological action of drotaverine
Drotaverine is an isoquinoline derivative that exhibits an antispasmodic effect on smooth muscle cells by inhibiting the enzyme phosphodiesterase IV (PDE IV). The consequence of this is an increase in the concentration of cAMP, which inactivates the light chain of myosin kinase, which, in turn, leads to relaxation of smooth muscles. Drotaverine is effective for spasms of smooth muscles of both nervous and muscular etiology. Regardless of the type of autonomic innervation, drotaverine acts on the smooth muscle tissue cells of the walls of the hollow organs of the digestive, genitourinary and cardiovascular systems.
Professional medical articles regarding the use of drotaverine in the treatment of the gastrointestinal tract
- Belousova E.A. Antispasmodics in gastroenterology: comparative characteristics and indications for use // Pharmateka. - 2002. - No. 9. – p. 40–46.
Indications for use of drotaverine
Drotaverine is close in chemical structure and mechanism of action to papaverine. Both are phosphodiesterase (PDE) type IV inhibitors and calmodulin antagonists. At the same time, the selectivity of the action of drotaverine in relation to PDE is noticeably higher and the selectivity of its effect on smooth muscles is 5 times higher than that of papaverine. Drotaverine is effective for spasms of smooth muscles of both nervous and muscular etiology. Regardless of the type of autonomic innervation, drotaverine affects the smooth muscles of the digestive, urogenital and vascular systems.
In the treatment of pain of mild and moderate intensity in the abdomen and pelvis, drotaverine, along with other antispasmodics (papaverine, mebeverine, hyoscine butyl bromide, otilonium bromide and others) is a first-stage drug, which, in the absence of a positive effect with monotherapy with antispasmodics and with long-term and for increasing abdominal pain, they are replaced with second-stage drugs.
Drotaverine has a more pronounced antispasmodic effect than papaverine and usually quite effectively relieves acute spasms of various origins. However, when chronic pathology, such as irritable bowel syndrome or biliary tract disorders, oral administration of these drugs in therapeutic doses is often insufficient, and it becomes necessary to increase their dose or parenteral administration. Although drotaverine and papaverine are generally well tolerated, in large doses or with intravenous use they can cause dizziness, decreased myocardial excitability, impaired intraventricular conduction, up to the development of atrioventricular block. In such a situation, drotaverine and papaverine should be replaced by mebeverine, which has selectivity against the smooth muscles of the digestive tract, mainly the colon, and does not affect the smooth muscle walls of blood vessels. 
There are a number of publications in which prominent Russian gastroenterologists express the opinion that in the treatment of gastrointestinal diseases, mebeverine is more effective and has fewer side effects than drotaverine.
Also, leading Russian gastroenterologists warn that drotaverine, like other myogenic antispasmodics, due to their relaxing effect on the lower esophageal sphincter, are not recommended for gastroesophageal reflux disease.
Contraindications:
- hypersensitivity to drotaverine
- severe liver or kidney failure
- severe heart failure (low cardiac output syndrome)
- Children under 1 year of age are not recommended to take Drotaverine tablets.
Doses and methods of use of drotaverine
- adults should take drotaverine 2-3 times a day so that the daily dose is 120-240 mg
- children over 6 years old take drotaverine 2–5 times a day based on a daily dose of 80–200 mg
- children from one to 6 years old take drotaverine 2-3 times a day so that the daily dose is 40-120 mg
Side effects when taking drotaverine
Rarely - nausea, constipation, headache, dizziness, insomnia, rapid heartbeat. Very rarely - hypotension.Caution is required when joint use drotaverine with levodopa, since drotaverine reduces the antiparkinsonian effect of the latter and may increase tremor and rigidity.
Due to the fact that drotaverine tablets contain lactose, patients suffering from lactose intolerance may have problems with gastrointestinal tract. Therefore, drotaverine tablets should not be prescribed to patients suffering from lactose deficiency, galactosemia, or impaired absorption of glucose or galactose.
Due to the lack of necessary clinical data during pregnancy prescribing drotaverine is possible only with a careful assessment of the benefit-risk ratio, and when breastfeeding, it is not recommended to prescribe drotaverine .
For driving a car drotaverine therapy has no effect
drotaverine: Bespa, Bioshpa, Vero-Drotaverine, Droverine, Droverine solution for injection 2%, Drotaverine, Drotaverine MS, Drotaverine forte, Drotaverine-AKOS, Drotaverine-KMP, Drotaverine-MIK, Drotaverine-STI, Drotaverine-UBF, Drotaverine-FPO , Drotaverine-Ellara, Drotaverine hydrochloride, Drotaverine hydrochloride tablets 0.04 g, No-shpa, No-shpa forte, Nosh-Bra, Spasmol, Spasmonet, Spasmonet forte, Spasmoverine, Spakovin.
Trade names of drugs with active ingredients drotaverine + codeine + paracetamol: No-shpalgin, Unispaz.
Drotaverine is widely represented in the pharmaceutical markets of countries former USSR, some Eastern European and Asian countries. In the USA and Western European countries, drotaverine does not have permission for use.
Manufacturer's instructions
By medical use medicines containing drotaverine: 
- For Russia:
