Home Removal What happens if I miss amlodipine for 3 days? Amlodipine

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What happens if I miss amlodipine for 3 days? Amlodipine

Amlodipine is a very powerful drug for lowering blood pressure in hypertensive patients and should be taken with caution. Many people make the mistake of drinking Amlodipine and not seeing results in the next hour or two, and taking additional medications to lower blood pressure.

The fact is that this drug begins to act 5-6 hours after taking it and lowers blood pressure for a long time. Therefore, there is no need to expect it to decrease immediately.

Amlodipine has a lot side effects and should not be taken without a prescription.

Most often it causes swelling, but this does not mean that the drug is not suitable for you. Many doctors think this is normal.

5 mg per day of this drug is prescribed if the pressure remains consistently high for a long time (more than 170/100).

But when the pressure stabilizes, the dose of Amlodipine should be gradually reduced and switched to weaker drugs.

Amlodipine can be taken for a long time. The drug is effective until 50 hours. Unusual duration of action. How to prescribe? The first obvious answer is 1 time every 2 days. The patient will most likely get confused and mix up the days. Therefore, it was decided to prescribe the drug every day at half the dose. Dose 10 mg, respectively - half dose - 5 mg. Many patients refuse to accept lifelong use of the drug, believing in recovery. When taking this drug, the blood pressure normalizes and they stop taking pills. Having stopped drinking Amlodipine, patients will not feel worse for another 3-4 days, since the drug is eliminated for a long time, the remains of the drug in the blood will maintain more or less normal blood pressure. It is imperative to convince the patient to take Amlodipine daily. If you missed a dose once, it’s no big deal, take it again.

there is a downside to the drug - it interacts with bromelains, which are found in grapefruits and pineapple peels. If it is unlikely that anyone will eat the pineapple peel, then you should refrain from eating pineapples. Consumption of grapefruit and juice from it sharply increases the concentration of Amlodipine, pronounced dilatation (expansion) of blood vessels, a drop in blood pressure, and orthostatic hypotension occur (when standing up from a horizontal position, collapse and fainting may occur).

The medicine Amlodipine is used to lower blood pressure. To answer your question, you should refer to the official instructions for the drug Amlodipine, which you can read on this resource.

This section does not contain information about the maximum periods for taking Amlodipine. Therefore, long-term use of this medicine is allowed, but this should only be done under the supervision of the attending physician.

Hello! I can’t understand the expression - gradually reduce the dose of the drug. Mom takes 1 tablet (5 mg) at night. That's what the doctor ordered. On this moment My mother’s blood pressure remains stable at 130/70. And sometimes it’s 117/50. The doctor warned that you should not suddenly stop taking the drug. Reduce the dose, does this mean taking 2.5 mg? How many days? And after how many days can you stop taking amlodipine? We once tried to quit gradually. The dose was reduced to 2.5 mg for 10 days. Then take it every other day for another 10 days. And then they stopped altogether. After 2 days, my mother’s blood pressure jumped to 230/110. The ambulance said - under no circumstances stop taking this drug. What to do?

Amlodipine is a medicine that lowers blood pressure. When you take this medicine, you need to wait 5-6 hours and the pressure should decrease. How long can I take this drug? It all depends on how often you lower your blood pressure. You should definitely consult with your doctors as every medicine or drug can be harmful at some time.

Pressure surges are one of the most common problems of modern people. Therefore, every person is looking for the most effective and safe medicine intended to normalize blood pressure. One of the most common modern 3rd generation drugs is Amlodipine, the instructions for use of which should be studied in detail, and also find out at what pressure it is used.

Composition of the drug

This medication is available in the form of tablets that contain the main active substance – amlodipine besilate. In addition to it, the medicine also contains auxiliary components:

lactose;
calcium stearate;
croscarmellose sodium.

White tablets, coated with a colorless film, are sold in sheets packaged in a large cardboard pack. You can buy Amlodipine at any pharmacy. For Russia the price is approximately 40 rubles. As for Ukraine, this drug can be purchased at average price 15 UAH

Instructions for use

Most often, Amlodipine is used to normalize blood pressure. It is taken by people suffering from hypertension. The drug is also prescribed for the following diseases and ailments:

treatment of hypertension at the initial stage of development;
with irregular, single surges in blood pressure;
with stable angina;
for spasms blood vessels.

Amlodipine helps lower high blood pressure and also improves functioning of cardio-vascular system. Therefore, if a patient has a rapid heartbeat along with high blood pressure, then the drug will bring the body to a normal state.

Important to remember! Before using Amlodipine, you should consult a specialist! Only he can prescribe the drug, because self-treatment can cause complications, and with the wrong dosage, unpleasant side effects.

Reception features

This medicinal product contains potent substances. Therefore, during treatment with Amlodipine, you must adhere to the following rules:

During the appointment, you should monitor your weight and also see a dentist. The medicine may cause excess weight or severe bleeding gums.
Do not stop taking the drug abruptly. This may provoke a resumption of attacks of high blood pressure, and may also be observed high heart rate.
During the treatment period, people whose professional activity associated with increased attentiveness and responsibility, it is better to take a vacation. This drug causes constant drowsiness or dizziness.
In patients with liver failure, Amlodipine should be taken under regular specialist supervision.

The relatively low cost of the drug allows it to be used by all segments of the population. However, you should consult your doctor before use.

How to use

Depending on the problems with blood pressure, the dosage is prescribed differently:

Infrequent increases in blood pressure. This indicator can be reduced by taking 1 tablet once a day. It is better to take the tablet in the morning, as it begins to act after a couple of hours. If there is no improvement in the condition, you need to increase the dosage to 2 tablets per day, taking them once. With long-term use of the drug, the dose should be reduced to 0.5 tablets per day. The course of treatment is 1 week. An increase in duration can only be prescribed by a specialist.
Arterial hypertension. People suffering from this disease need to take Amlodipine 0.5 tablets per day. This treatment has a supportive effect on the body. You should take the drug in this mode constantly.
Impaired functioning of the cardiovascular system. For heart disease, experts recommend taking 1 tablet once a day. If improvement is not observed for a long period of time, then you can increase the dose to 2 tablets for a while. How long should I take this drug? Most often, doctors recommend using it for heart problems. permanent basis.

Important to remember! The duration of treatment with Amlodipine is determined only by a specialist! The patient should regularly visit the doctor, who will evaluate the state of health during the period of therapy and the advisability of continuing to take the pills.

Side effects

If you take this drug excessively, a person may experience the following ailments:

From the cardiovascular system: swelling of the upper and lower limbs, pain in the heart area, shortness of breath with minor exertion, increased or decreased heartbeat.
From the central nervous system: rapid fatigue, dizziness with loss of consciousness, sleep disturbances, causeless irritability, anxiety, apathy.
From the outside gastrointestinal tract: nausea with vomiting, painful sensations in the lower part abdominal cavity, constipation or diarrhea, constant thirst, exacerbation of gastritis.

The patient may also have problems with intimate life, painful urination, allergic rashes on the skin, increased body temperature.

Important to remember! You should adhere to the dosage prescribed by your doctor! This will help protect the body from the above side effects.

Contraindications for use

This drug is strictly contraindicated in the following cases:

during pregnancy – the active component of Amlodipine negatively affects the development of the fetus;
period breastfeeding;
for diabetes mellitus;
with low blood pressure;
persons under 18 years of age;
for lactose intolerance, as well as hypersensitivity to other components of the drug.

Also, if a patient experiences severe allergic reactions after consuming Amlodipine, such treatment should be stopped and consult a specialist about the use of similar drugs.

Norvasc or Amlodipine - which is better?

Norvasc is a drug whose active substance is amlodipine. If we compare this imported medicine with Amlodipine, then there is no significant difference in the effect on the body. Norvasc is several times more expensive than the domestic analogue, but in terms of the degree of purification and concentration of the active substance, the foreign drug has an advantage.

A package of Norvasc costs on average 400 rubles in Russia. In Ukraine it can be purchased for approximately 130 UAH. Therefore, many people suffering from regular increases in blood pressure cannot afford such treatment and choose Amlodipine.

Analogues of the drug

In addition to Norvasc, modern pharmacology offers many more drugs similar in composition and effect on the body:

Duactin. This medicine is available in capsules. Prescribed for hypertension, as well as for chronic palpitations. The advantage is the minimum number of contraindications for use.
Tenox. Used for severe forms of hypertension and chronic angina. The drug is not suitable for persons suffering from acute heart failure.
Normodipin. In a short time it normalizes high blood pressure and improves the functioning of the cardiovascular system. Contraindicated in people who have had acute heart attack myocardium.
Emlodin. A fairly inexpensive analogue of Amlodipine. It is strictly forbidden to use in severe hypotension, as well as in cases of impaired functioning of the left ventricle.

Regardless of the choice of a particular drug for high blood pressure, it is necessary to agree on its dosage and advisability of use with a specialist.

Amlodipine is one of the main drugs used to stabilize blood pressure in patients with hypertension and recurrent attacks of angina.

This antihypertensive medication belongs to the group of calcium antagonists, although this name does not fully reflect its mechanism of action.

However, the term “calcium channel blockers” used in foreign medical literature is more correct.

To better understand how Amlodipine and its analogues work, it is necessary to say a few words about the general regulation of vascular tone.

The walls of the main arteries, peripheral arterioles and all other vessels in the body are composed of smooth muscle cells. Accordingly, muscle tension leads to a decrease in their clearance and an increase in pressure, and vice versa.

This process is controlled using several mechanisms:

Impulses of the sympathetic and parasympathetic divisions of the autonomic (peripheral) nervous system.
Autoregulation, a change in vascular tone due to local excitation or relaxation, this occurs in the arteries of the brain, kidneys, lungs, and liver.
Humoral regulation with the help of substances circulating in the blood. These are hormones (renin, vasopressin, adrenaline, thyroxine and some others), various metabolites (for example, carbon dioxide or lactic acid), potassium and calcium ions. And if potassium has a vasodilating effect, then calcium leads to the opposite effect.

It must be said that this principle is used to regulate blood pressure in both adults and children. Calcium ions (Ca2+) not only participate in the control of vascular tone, but also provide a lot of other processes necessary for normal life. Their concentration in the blood increases with ischemic disease, hypoxia, arrhythmia and some other pathologies.

In large quantities, they stimulate metabolism at the cellular level, increasing their need for oxygen, causing dysfunction of many organs, promoting destructive changes in cells. Transport of calcium ions into the cell occurs with the help of specific proteins - calcium channels.

To date, several types of them are known, designated by the letters of the Latin alphabet L, T, N, P, Q, R, differing in conduction speed and location. L-type channels allow the slow passage of calcium ions into the cell.

They are located in the myocardium, in the sinus and atrioventricular nodes of the conduction system of the heart, smooth muscle tissue of blood vessels, ureters, skeletal muscles and other organs of the respiratory, digestive and genitourinary systems. L channels are also present on the platelet membrane.

Medicines from the group of calcium antagonists are united by the ability to reversibly block slow L-type calcium channels without affecting the total concentration of calcium ions in the body. In cardiological practice, these drugs have been used since the late 70s of the last century, since then their composition has been improved.

Currently, there are several groups of calcium antagonists:

Benzothiazepines (the main representative is Diltiazem).
Phenylalkylamines (eg Verapamil).
Dihydropyridine derivatives are the largest group, to which Amlodipine belongs.

Since 1995 it has been adopted additional classification, based on the tissue selectivity of the drugs and the duration of their action. Amlodipine belongs to the second generation drugs (according to some sources - the third). It selectively affects calcium channels located in cardiomyocytes and vessel walls, including coronary and cerebral arteries.

Amlodipine has the following properties:

antihypertensive;
antianginal (that is, they reduce the myocardial oxygen demand, reduce afterload and eliminate symptoms of ischemia);
increases blood flow to vital organs (heart, brain, kidneys);
diuretic with the release of sodium ions in the urine;
nephroprotective, due to improvement of intrarenal hemodynamics, prevention of tissue calcification;
slow down atherosclerotic changes in blood vessels.

Amlodipine, like most other calcium antagonists, is prescribed to patients orally in tablet form. After administration, the drug is quickly absorbed from the digestive tract; if the instructions for use are followed, its bioavailability reaches 80%.

In blood plasma, Amlodipine binds to proteins, mainly albumin and to a lesser extent lipoproteins. The maximum concentration is observed after 6-12 hours, and constant - after regular treatment for 7-10 days.

The active substance of the tablets undergoes slow metabolism in the liver and is excreted by the kidneys. According to reviews from doctors and patients, unlike other antihypertensive drugs (for example, from the group of β-blockers), Amlodipine does not affect potency, but can cause swelling of the lower extremities.

Currently, the combination of calcium antagonists with antihypertensive drugs of other pharmacological groups is of interest. For example, doctors often prescribe Amlodipine together with the angiotensin converting enzyme (ACE) inhibitor Enalapril to relieve high blood pressure.

Combination tablets have now appeared on the market, varying in price, and containing calcium channel blockers, a lipid-lowering agent and an ACE inhibitor or beta-blocker.

Amlodipine: what is it prescribed for, contraindications and release form

The blood pressure medicine Amlodipine is available in the form of tablets of 2.5, 5 and 10 mg. The package may contain 30, 60 or 90 pieces. Patients included complex therapy Amlodipine is prescribed.

What is it prescribed for:

Chronic ischemic heart disease, which is accompanied by attacks of angina, Amlodipine can be used alone or in combination with medications from the β-blocker group.
Hypertonic disease. Compared with other calcium antagonists, the tissue selectivity of Amlodipine is higher, and while providing a hypotensive effect, it does not affect contractility myocardium, sinus node function and atrioventricular conduction.

Amlodipine is not used to eliminate the symptoms of angina attacks; this requires nitrates (for example, Nitroglycerin). However, with long-term use, the drug prevents them.

Absolute contraindications to the treatment of diseases for which Amlodipine is prescribed are:

intolerance or allergic reaction to dihydropyridine derivatives;
children's age (up to 18 years) due to the lack of clinical trials, proving the effectiveness of the drug for use in children;
a persistent state of hypotension if the “lower” systolic pressure is 90 mmHg. and less;
cardiogenic shock;
rehabilitation after myocardial infarction (in the first 3 - 4 weeks);
aortic stenosis and left ventricular vascular obstruction.

Dose adjustment and monitoring of the patient’s condition is necessary in the following cases:

severe symptoms of bradycardia;
dysfunction of the sinus node;
severe liver pathologies (metabolism and excretion of the drug slow down), however, renal failure does not affect the concentration of Amlodipine in the blood and is not a contraindication to its use;
old age, the dosage of the drug is increased very slowly;
mitral valve stenosis;
congestive heart failure, long-term use of Amlodipine increases the risk of pulmonary edema.

Separately, manufacturers emphasize that Amlodipine (for which it is prescribed as described above) does not affect the results of laboratory tests of blood and urine. Doctors also note that in combination with dizziness and headache, the drug slows down the reaction rate. Therefore, it should be taken with caution in patients whose work depends on concentration.

Amlodipine: what does it help with, are there any differences depending on the manufacturer

Of all the calcium antagonists, Amlodipine, the release form of which is the same and does not depend on the manufacturer, is the most popular among cardiologists.

It is clear that many domestic and foreign pharmaceutical companies have launched the production of this medicine.

To designate a particular manufacturer original name active component, add the full or abbreviated name of the manufacturer.

However, this does not affect what Amlodipine helps with. For example this:

Amlodipine Zentiva from the company of the same name, one of the divisions of the French corporation Sanofi;
Vero-Amlodipine produced by the Russian Veropharm;
Amlodipine Teva, Israel;
Amlodipine-ZT from the Ukrainian company “Zdorovye”;
Amlodipine Sandoz, the drug is produced in Slovenia by the representative office of the Swiss company Sandoz;
Amlodipine Prana from the Russian "Pranapharm";
Amlodipine Agio, made in India.

This list can be continued, not counting the numerous drugs under the common name Amlodipine (for which it is better to check the medicine with a doctor), which is produced by about a dozen domestic pharmaceutical factories. Separately, you need to dwell on combination drugs that contain Amlodipine; the list of diseases that these drugs help with is the same.

However, these medications are more effective:

Niperten Combi(amlodipine + β-type adrenergic blocker bisoprolol);
Amzaar(amlodipine + angiotensin receptor antagonist losartan), an additional component increases resistance to physical stress, reduces total peripheral vascular resistance and normalizes pressure in the pulmonary circulation;
Duplecore(amlodipine + lipid-lowering component atorvastatin), the drug is prescribed for hypertension in combination with atherosclerosis, the drug reduces the level of cholesterol and low-density lipoproteins;
Ko-dalneva(amlodipine + ACE inhibitor perindopril + diuretic indapamide), the drug has a pronounced hypotensive effect.

The list of such combination drugs is much longer, but the principle of combining Amlodipine with other components that enhance its effect remains the same. Taking into account the trend towards an increase in the number of diseases of the cardiovascular system due to atherosclerosis, the connection with statins, which have a hypolipidemic effect, is of interest to doctors.

The selection of combination drugs based on Amlodipine should only be carried out by a doctor.

Let's look at the instructions for using the monodrug; they are the same for any of its varieties, regardless of the manufacturer. Typically, the initial daily dosage to reduce myocardial oxygen demand and prevent angina attacks is 5 mg.

Take an Amlodipine tablet once a day, and the degree of its dissolution in the digestive tract and absorption of the active component does not depend on food.

If there is no effect, the amount of medication is increased to 10 mg per day (also drunk once a day). For elderly patients, treatment begins with the use of 2.5 mg tablets, and then the dosage is increased.

The daily amount of Amlodipine should not exceed 10 mg.

Blood pressure tablets Amlodipine: side effects, overdose, use during pregnancy

Arterial hypertension during pregnancy is considered among priority problems modern medicine, since, according to WHO experts, 15-20% of women encounter it during pregnancy.

An increase in blood pressure occurs against the background of physiological hypertrophy of the myocardium (its mass increases to 30% by the end of the last trimester), an increase in heart rate, and vascular tone under the influence of sex hormones. Usually, in this case, Amlodipine is not needed during pregnancy; magnesium-based drugs and mild sedatives are sufficient.

When do pregnant women need antihypertensive therapy? There is no clear answer to this question. Doctors agree that women belonging to a low risk group (with blood pressure up to 140-160/90-110 mmHg) should be observed in a specialized hospital. And if there are no signs of damage to various organs, Amlodipine tablets are not prescribed.

It should be noted that, for obvious reasons, clinical trials of the drug for its effect on the unborn fetus have not been conducted. Therefore, to treat hypertension in pregnant women, choose the safest medicine with a minimum of side effects and complications.

These criteria are met by the latest generation calcium channel blockers with prolonged action, namely Amlodipine tablets (or its analogue Normodipine).

Despite numerous data on the safety of Amlodipine, based on observation of children who were born after treatment with this drug during the second and third trimesters of pregnancy, it is better to refrain from taking medications until the 8th week of fetal development. It is during this period that organogenesis occurs and the embryo is sensitive to the toxic effects of drugs.

The active component of Amlodipine tablets (amlodipine besilate) is excreted in breast milk, so if treatment is necessary, lactation should be stopped.

The main side effects of Amlodipine tablets are associated with its vasodilating (that is, relaxing) effect on peripheral vessels.

Therefore, more often than others, the following occur:

headache;
fever, redness of the face and neck;
violations heart rate(tachycardia or bradycardia);
swelling of the legs;
decreased blood pressure;
drowsiness;
dizziness.

Complications from the digestive, excretory and other systems develop much less frequently:

constipation or, conversely, diarrhea;
nausea, vomiting;
abdominal pain;
lack of appetite;
thirst due to dryness of the oral mucosa;
reversible liver damage;
dyspnea;
frequent painful urination;
muscle pain, cramps;
skin rash, appearance of age spots.

An overdose of Amlodipine tablets is very dangerous, as the drug can cause a severe decrease in blood pressure and bradycardia. Deterioration of the condition is fraught fatal. Therefore, when the first symptoms appear, it is necessary to give a large dose of adsorbent (activated carbon), lie down with your legs elevated, and call the doctors.

In the hospital, medications are used to maintain the normal functioning of the cardiovascular system, provide constant control of the rhythm of myocardial contractions, lung function and urination volume.

The packaging of the drug usually contains several blisters with Amlodipine tablets. In addition to the main component, they contain auxiliary substances that facilitate pressing at the factory, dissolution in the digestive tract and distribution in the body. These are microcrystalline cellulose, potato starch, lactose, calcium and magnesium stearate.

Blood pressure tablets Amlodipine are combined with drugs for the treatment of diabetes, non-steroidal anti-inflammatory drugs, most antibiotics (except Clarithromycin, Erythromycin and their analogues), alcohol (in reasonable quantities).

The hypotensive effect of Amlodipine tablets is enhanced by the following groups of medications:

nitrates;
ACE inhibitors;
diuretics;
statins;
neuroleptics;
α- and β-blockers;
antiviral drugs.

The concentration of Amlodipine in the blood increases when drinking a large amount of grapefruit juice, so it is better to exclude this drink from the diet.

The effectiveness of Amlodipine blood pressure tablets is reduced by the influence of calcium supplements and the antifungal agents Ketoconazole and Itraconazole. Side effects from the combination of Amlodipine with the listed medications are especially pronounced in old age.

Medicine Amlodipine for blood pressure: analogues, prices and reviews

There are many analogues of the drug Amlodipine. The composition of these drugs is the same, the principle of action is the same. They reduce the load on the myocardium, the tone of the coronary and peripheral vessels.

Instead of Amlodipine, the cardiologist may suggest (for an adequate comparison, prices for 30 tablets of 5 mg will be given):

Amlovas, made in India, 300 rubles;
Tenox, KRKA company, Slovenia, 272 rubles;
Normodipin, Gedeon Richter, Hungary - Russia, 370 rubles;
Norvasc, Pfizer, USA, 540 rubles.

The cost of the Russian-made Amlodipine drug, as well as Amlodipine Sandoz and Amlodipine Teva, ranges from 150-180 rubles. However, doctors refute the popular opinion (which is also actively spreading on social networks) about the complete similarity of all the listed drugs, when, for example, Norvasc is no different from Amlodipine.

A major role in the production of any drug is played by the degree of purification of the active substance, various excipients (and their exact concentration). It is these indicators that ensure bioavailability, and, consequently, the effectiveness of the drug, and less severity of side complications.

And for the same reason, Normodipine or Norvasc has a vasodilator and hypotensive effect in a particular patient, but the drug Amlodipine does not. By the way, this situation is not always observed.

According to reviews from cardiologists, Amlodipine for blood pressure improves the long-term prognosis of hypertension aggravated by other pathologies (diabetes mellitus, coronary heart disease, cerebrovascular accidents) by preventing angina attacks, relaxing smooth muscles and dilating the vascular wall. In addition, the drug ensures the maintenance of normal blood pressure levels without any significant side effects.

Amlodipine represents

vasodilator drug from the group of slow calcium channel blockers, which has the property of reducing arterial

pressure

and reduce the need for oxygen in the heart muscle, thereby preventing angina attacks. Amlodipine is effective in relieving and preventing angina attacks in people who are not helped by nitrates (nitroglycerin, etc.). The drug is also effective for lowering blood pressure in people who are not helped by drugs from the group of beta-blockers (Atenolol, Acebutolol, Bisoprolol, Betaxolol, Metoprolol, Nadolol, Nebivolol, Propranolol, Sotalol, Timolol, etc.).

Types, names, release forms and composition of Amlodipine

Currently, Amlodipine is available in several varieties, which differ from each other only by small additional words in the names. The fact is that all varieties of the drug contain the word “Amlodipine” in the name. However, to make the name unique, each pharmaceutical company or plant adds another abbreviation to the word “Amlodipine”, reflecting the short and recognizable name of the manufacturer itself, for example, “Amlodipine Teva”, “Vero-Amlodipine”, etc.

Currently, varieties of Amlodipine are available under the following names:

Amlodipine;
Amlodipine Agio;
Amlodipine Alkaloid;
Amlodipine Biocom;
Amlodipine Borimed;
Amlodipine Zentiva;
Amlodipine ST;
Amlodipine Cardio;
Amlodipine Prana;
Amlodipine Sandoz;
Amlodipine Teva;
Amlodipine Chaikapharma.

Such additional abbreviations in names are necessary for pharmaceutical companies to register the drug they produce as a unique product, the rights to which belong only to them. This is done in connection with the peculiarities of the succession of modern pharmaceutical plants, which have become joint stock companies, with state enterprises of the former USSR. The fact is that Amlodipine was developed and began to be produced back in the USSR, when it was produced by all pharmaceutical factories under the same name.

After the transition to a market economy and the privatization of enterprises, each pharmaceutical plant had the technology for producing Amlodipine, left over from the unified system of the USSR, but now it was necessary to make its drug unique, that is, branded. And for this, an abbreviation was added to the usual, old and well-recognized name “Amlodipine”, meaning the short name of the pharmaceutical plant. But, despite the “additive” in the name, the drug remains the same Amlodipine, since it is produced using old technology. That is why all varieties of Amlodipine, despite different but very similar names, are the same drug. The only difference between the varieties of Amlodipine may be in their quality: that is, the drugs from one plant are better than the other, since it better adheres to the standards of production technology, uses more raw materials High Quality etc. Otherwise, there are no differences between the varieties, so in the further text of the article we will combine them under one common name"Amlodipine."

All varieties of Amlodipine are available in a single dosage form – tablets for oral administration. As an active ingredient, the tablets contain amlodipine in three possible dosages - 2.5 mg, 5 mg or 10 mg. In this regard, tablets are in use various dosages often indicated by names "Amlodipine 5", "Amlodipine 10" or "Amlodipine 2.5", where the number corresponds to the dose of the active component.

However, in the instructions for use you can often find an indication that the tablets contain not 5 or 10 mg of amlodipine, but 6.9 and 13.8 mg amlodipine besilate respectively. This does not mean that the dosage of the active substance in such tablets is higher, since in fact it is 5 or 10 mg of amlodipine. The manufacturer simply indicates how much amlodipine besylate is contained in each tablet, which, of course, is slightly more, since its mass is higher. But if you recalculate how much amlodipine besylate contains pure amlodipine, you will get the same well-known figures - 5 mg and 10 mg, respectively.

Amlodipine tablets from different manufacturers may contain different substances as auxiliary components. Therefore, to clarify the composition of the auxiliary components, you should always carefully read the leaflet with instructions included in the package of tablets from each manufacturer. Most often The following substances are added to Amlodipine tablets as auxiliary components:

Crospovidone;
Lactose monohydrate;
Povidone;
Calcium stearate.

Tablets are available in packs of 10, 20, 30, 40, 50 or 100 pieces. The tablets usually have a flat-cylindrical shape, are scored and beveled on different sides, and are colored white or white-cream.
Amlodipine + Lisinopril and Amlodipine + Valsartan

The drugs Amlodipine + Lisinopril and Amlodipine + Valsartan are separate combination drugs that, in addition to amlodipine, contain other active substances.

What is the difference between Amlodipine Teva and Amlodipine?

Amlodipine and Amlodipine Teva contain the same active substance in the same dosages, therefore, at first glance, they are no different from each other. However, this is not true, since there are differences, and sometimes very significant ones.

Amlodipine Teva mainly differs from Amlodipine in that it is produced in pharmaceutical factories in Hungary under the direction and technology of the Israeli corporation TEVA Pharmaceutical Industries, Ltd. Amlodipine is simply produced by Russian pharmaceutical factories. Accordingly, the production technology of the same drug is significantly different, which determines all the other differences between Amlodipine Teva and Amlodipine.

Firstly, the quality of Amlodipine Teva is often higher than that of Amlodipine produced by most Russian pharmaceutical factories, which is due to several factors. For the production of Amlodipine Teva, a purer active substance with a minimum amount of impurities is used. That is, before putting it into a tablet, the active component is first purified from impurities, tested according to various parameters, and only after that is allowed onto the production line. As a result, the active substance without impurities has a more pronounced therapeutic effect, causing excellent effectiveness of the drug and minimal quantity, severity and risk of side effects. That is, by purifying the active substance, TEVA Pharmaceutical Industries, Ltd. Achieves both high efficiency and low side effects of Amlodipine.

However, such purification and testing of the active substance is quite expensive and labor-intensive, and in addition, requires the availability of developed and tested technology. Therefore, at many Russian pharmaceutical plants, the active substance is not purified; it is immediately put into the technological cycle. And the active substances themselves, as a rule, are purchased from large chemical laboratories in India and China, which produce them in large quantities and, accordingly, of varying quality. The same active substance with different amounts of impurities will have different therapeutic effects. Moreover, a substance with a smaller amount of impurities has a better therapeutic effect, and a substance with a larger amount, accordingly, has a worse effect. Thus, the effectiveness of Amlodipine will depend entirely on how pure the active substance is in it. And since obtaining a substance well purified from impurities requires costs, then, accordingly, the more expensive Amlodipine will be of better quality compared to the cheaper one.

Thus, the main difference between Amlodipine Teva and Amlodipine is its better quality and, accordingly, higher cost. In addition, the instructions for Amlodipine Teva may indicate side effects that are not included in those for Amlodipine. However, this does not mean that Amlodipine does not cause the same side effects as Amlodipine Teva. On the contrary, it does, and even much more often. Simply TEVA Pharmaceutical Industries, Ltd. monitors the clinical use of Amlodipine Teva and records all side effects that occur, after which it supplements the instructions by adding them to the appropriate section. Russian manufacturers Amlodipine is not monitored for side effects and, in principle, has little interest in everything that happens to the drug during clinical application. Therefore, their instructions are written once and do not change for a long time. But this only reflects the fact that the manufacturer does not record the properties of its drug and does not make timely amendments to the instructions.

Amlodipine - what does it help with? (therapeutic effect)

Amlodipine blocks the functioning of calcium channels located on the membranes of myocardial cells and vascular walls of arteries. Thanks to channel blocking

does not enter the cells through the membrane, as a result of which the muscle tone of the vessels and myocardium decreases, and their relaxation occurs. Accordingly, relaxed blood vessels become wider, which facilitates the flow of blood through them and, thus, lowers blood pressure.

Dilatation of myocardial vessels and reduction of tension themselves muscle cells leads to the fact that the heart muscle requires less oxygen to function normally. After all, relaxed muscles need less oxygen than tense muscles. Accordingly, the myocardium acquires the ability to function normally under conditions of a small amount of oxygen. And thus, a person suffering from angina pectoris can increase exercise tolerance and reduce the frequency and severity of angina attacks.

The effect of lowering blood pressure of Amlodipine is called antihypertensive (hypotensive), and reducing the myocardial oxygen demand is called antianginal. It is the hypotensive and antianginal effect that are the main effects of Amlodipine used in clinical practice.

Due to its high safety and the absence of reflex heartbeat or a sharp decrease in blood pressure, Amlodipine can be used to treat people suffering, in addition to angina, diabetes, gout or bronchial asthma.

The antianginal and hypotensive effects of Amlodipine provide the following action:

Expands the arteries and arterioles of the myocardium in all its parts. It is especially important that Amlodipine dilates blood vessels in areas of the myocardium suffering from ischemia (lack of oxygen). That is, the drug improves blood supply not only to normal parts of the heart muscle, but also to those whose vessels are clogged with atherosclerotic plaques;
Increases the amount of oxygen supplied to myocardial cells per unit time;
Reduces the degree of myocardial ischemia in angina pectoris;
Reduces the load on the heart muscle;
Reduces myocardial oxygen needs to operate normally or under load;
Reduces the frequency of angina attacks;
Reduces the amount of nitroglycerin used to relieve angina attacks;
Prevents constriction of heart vessels, including when smoking;
Increases endurance and tolerance of physical and emotional stress during angina pectoris;
Slows the progression of angina pectoris;
Reduces the degree of myocardial hypertrophy of the left ventricle of the heart;
Gently reduces blood pressure;
Prevents thickening of the internal lining of the walls of the blood vessels of the heart and reduces mortality in people suffering from atherosclerosis with stenosis of up to 3 or more arteries, angina pectoris, as well as those who have had myocardial infarction or percutaneous angioplasty;
With regular course use, it reduces the frequency of hospitalizations for unstable angina and progression of chronic heart failure.

Amlodipine does not lead to a sharp decrease in blood pressure, does not reduce exercise tolerance, does not cause reflex heartbeat and reduces the degree of platelet aggregation.

The primary effect of Amlodipine develops 2 to 4 hours after administration and persists for 24 hours.

Indications for use

Amlodipine tablets are indicated for use as part of complex therapy for the following diseases of the cardiovascular system:

Arterial hypertension (the drug can be used as monotherapy or in combination with diuretics, beta blockers or ACE inhibitors);
Angina pectoris (stable) and Prinzmetal (can be used as a single drug of therapy or in combination with other antianginal drugs, for example, Riboxin, Preductal, etc.);
Painless form of myocardial ischemia;
Coronary heart disease in combination with heart failure or without it;
Dilated cardiomyopathy with severe chronic heart failure (Amlodipine is used as part of complex therapy).

Amlodipine - instructions for use Dosage and duration of drug use

Amlodipine tablets should be taken orally, swallowing them whole, without biting, breaking, chewing or crushing in any other way. The tablet should be taken with a small amount of non-carbonated

(half a glass is enough).

Amlodipine can be taken regardless of food intake, since food does not affect the extent and speed of absorption of the drug into the bloodstream. Amlodipine, taken before, during or after a meal, is absorbed equally long - within 2 - 3 hours, as a result of which the therapeutic effect appears 2 - 4 hours after taking the tablet. The drug is taken once a day, and it is optimal to do this in the morning, so that you can monitor your own well-being, as well as evaluate the effectiveness and tolerability of Amlodipine.

At hypertension In order to reduce blood pressure, Amlodipine should be taken 5 mg (1 tablet) once a day. If blood pressure does not decrease to the required limits after 1 - 2 weeks of taking Amlodipine 5 mg 1 time per day, then, provided the drug is well tolerated, its dosage can be increased to 10 mg. Accordingly, Amlodipine should be taken 10 mg once a day. The drug at a dose of 10 mg once a day is taken until it is possible to achieve a stable decrease in blood pressure and keep it within normal limits without pronounced fluctuations during the day.

After this, they switch to taking Amlodipine in a maintenance dosage - 2.5 - 5 mg once a day. Moreover, first the dose is reduced to 5 mg and taken for a week. Then reduce the maintenance dose to 2.5 mg and monitor blood pressure readings. If they are normal, that is, blood pressure remains within normal limits and there are no fluctuations, then Amlodipine continues to be taken at a maintenance dosage of 2.5 mg continuously (for years). If the blood pressure begins to rise and fall sharply when taking 2.5 mg of Amlodipine per day, then you should return to the maintenance dosage of 5 mg per day and take the drug in this mode for a long time.

At arterial hypertension Amlodipine in maintenance dosages is taken continuously, without any breaks. The drug is discontinued by a doctor only if it has become ineffective or a course of treatment with other medications is necessary. In other cases, Amlodipine cannot be discontinued, since the drug should be taken constantly to maintain blood pressure levels within safe limits.

For any type of angina In order to prevent attacks and improve exercise tolerance, Amlodipine should be taken at a dose of 5 mg once a day for 2 to 3 weeks. Then, if necessary and against the background of normal tolerability, the dose of Amlodipine is increased to 10 mg per day and taken in this regimen for several months to prevent angina attacks.

For dilated cardiomyopathy, combined with severe heart failure, Amlodipine is started at 5 mg once a day for 1 to 3 weeks. After this, if the drug is well tolerated, the dosage is increased to 10 mg per day and taken for several months in a row. If Amlodipine 10 mg per day is poorly tolerated, then the dosage should be reduced and taken 5 mg once a day for several months.

For coronary heart disease, Amlodipine should be taken at 2.5–5 mg once a day. If this dosage is sufficient, then it is not increased and the drug is continued to be taken at 5 mg once a day for several months. If the effect of Amlodipine is insufficient, then the dosage is increased to 10 mg per day and taken for several months.

The maximum permissible daily dosage of Amlodipine is 10 mg. All daily dose The drug should be taken at a time, preferably in the morning. In case of severe liver diseases, Amlodipine is started at a dosage of 2.5 mg per day and increased only to 5 mg per day. When using Amlodipine simultaneously with diuretics, beta blockers and ACE inhibitors, there is no need to reduce their dosage. There is also no need to reduce dosages in people over 65 years of age and those suffering from renal failure, but they need to regularly determine creatinine clearance using the Rehberg test throughout the entire period of use of Amlodipine.

The duration of Amlodipine administration is determined by the doctor depending on the results of therapy, which are assessed using functional stress tests, laboratory tests And various methods hardware diagnostics. Amlodipine is usually taken for a long time - for several months for heart diseases (angina pectoris, ischemia, cardiomyopathy) and several years for hypertension.

special instructions

During the entire period of use of Amlodipine, body weight and sodium intake should be monitored, for which it is necessary to follow a low-salt diet.

In addition, you should visit regularly

dentist

(once every three months) in order to prevent

soreness bleeding

hyperplasia

In case of angina pectoris, the drug should be discontinued gradually to avoid a sharp deterioration in the condition and course of the disease.

Amlodipine should not be used to relieve a hypertensive crisis or an attack of angina. Also, Amlodipine should not be used for therapy in the first days after myocardial infarction.

Women should use contraceptive methods during the entire period of use of Amlodipine, since the drug cannot be taken during pregnancy.

People weighing less than 40 kg should take Amlodipine in half dosages - 2.5 mg per day initial and 5 mg per day maintenance.

Use during pregnancy and breastfeeding

In experimental studies on animals, Amlodipine was found to have a negative effect on the fetus. Clinical data and experience with

pregnancy

and during

breastfeeding

are absent in women, as a result of which it is not known for certain whether Amlodipine has a negative effect on the fetus. Therefore, the use of Amlodipine during pregnancy and breastfeeding is prohibited, but theoretically possible. The drug should be used during pregnancy only if the benefits outweigh all possible risks.

In principle, while using Amlodipine, it is recommended to use contraceptive methods to prevent pregnancy, which may be negatively affected by the drug.

It is not known whether Amlodipine passes into breast milk. However, other drugs from the group of calcium channel blockers (for example, Nifedipine, Isradipine, Nimodipine, etc.) pass into breast milk. Therefore, if it is necessary to use Amlodipine, you should stop breastfeeding and transfer the child to artificial milk formula.

Impact on the ability to operate machinery

At the beginning of Amlodipine therapy, a person may experience

dizziness

and drowsiness, so it should be taken with caution by people whose work requires a high reaction speed and concentration, for example, drivers, conveyor operators, etc. But in general, the drug can be taken by people whose work involves operating machinery.

Overdose

An overdose of Amlodipine is possible and is manifested by the following symptoms:

Marked decrease in blood pressure;
Reflex tachycardia (strong heartbeat, which becomes more frequent the lower the blood pressure);
Excessive dilation of peripheral small vessels with the development of persistent hypotension, which can turn into shock with a fatal outcome.

To eliminate an overdose, it is necessary, first of all, to rinse the stomach with a weak solution of potassium permanganate. Gastric lavage is especially effective within 2 hours after an overdose. Within an hour after gastric lavage, you should take the sorbent ( Activated carbon, Polyphepan, Polysorb, Filtrum, Enterosgel, etc.). Subsequently, symptomatic therapy is carried out aimed at maintaining the normal functioning of vital organs and systems. To restore normal tone of blood vessels, Dopamine is administered intravenously. And to reduce the severity of the effect on the heart, calcium gluconate is administered intravenously.
Interaction with other drugs

At joint use Amlodipine with the following drugs

the severity of its hypotensive and antianginal effects increases:

Antianginal drugs (Nitroglycerin, Riboxin, Preductal, etc.);
Diuretics (Chlorthalidone, Clopamide, Xipamide, Indapamide, Hydrochlorothiazide, Methyclothiazide, Bendroflumethiazide, Polythiazide, Furosemide, Bumetanide, Piretanide, Torsemide and ethacrynic acid);
ACE inhibitors (Captopril, Ramipril, Enalapril, Lisinopril, etc.);
Beta blockers (Timolol, Bisoprolol, Celiprolol, Metoprolol, Sotalol, Atenolol, Propranolol, Nebivolol, etc.);
Nitrates (Nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, Molsidomine);
Alpha1-adrenergic blockers (Alfuzosin, Tamsulosin, Omnic, Revokarin, Fokusin, Prazosin, Doxazosin, Artesin, Zoxon, Kamiren, Cardura, Tonocardin, Terazosin, Kornam, Setegis) - only the hypotensive effect is enhanced;
Neuroleptics (Aminazine, Tizercin, Nozinan, Etaperazine, Triftazine, Stelazine, Fluorphenazine, Moditen, Sonapax, Piportil, Haldol, Halofen, Trancodol, Truxal, Azaleptin, Leponex, Zyprexa, Rispolept, Semap, Pimozide) - only the hypotensive effect is enhanced;
Amiodarone – only the hypotensive effect is enhanced.

Reduce the severity of the hypotensive effect of Amlodipine, which can provoke a sharp increase in blood pressure with the subsequent development of a hypertensive crisis, the following drugs:

Sympathomimetics (Epinephrine, Norepinephrine, Midodrine, Phenylephrine, Dobutamine);
NSAIDs (Indomethacin, Aspirin, Paracetamol, Ketorol, Ketanov, Nimesulide, Nise, Meloxicam, Voltaren, Xefocam, Ibuprofen, Nurofen, etc.);
Anesthesia agents (Ftorotan, Enflurane, Isofloran, Thiopental sodium, Propofol, Ketamine, Propanidide, nitrous oxide, etc.);
Estrogens (Mirena, Klayra, Belara, Zoely, Janine, Migeis, Iprozhin, Klimen, etc.);
Orlistat.

Amlodipine in rare cases may cause an increase in the effect of antiarrhythmic drugs.

Calcium supplements reduce the severity of the therapeutic effect of Amlodipine.

Simultaneous administration of Amlodipine in a dosage of 10 mg and Simvastatin in an amount of 80 mg increases the degree of absorption last drug by 77%. Therefore, in such cases, the dosage of Simvastatin should be reduced to 20 mg.

A single dose of 100 mg of Sildenafil (Viagra) or alcohol does not affect the therapeutic effects of Amlodipine in people suffering from arterial hypertension.

Antiviral drugs (Ritonavir, Tamiflu, Acyclovir, Ganciclovir, etc.) increase the concentration of Amlodipine in the blood plasma.

When taking Amlodipine simultaneously with lithium salts, nausea, vomiting, diarrhea, ataxia (impaired coordination of movements), tremors of the limbs and tinnitus may occur.

Vero-Amlodipine and Amlodipine Prana - instructions for use

Instructions for using any type of Amlodipine, including Vero-Amlodipine and Amlodipine Prana, are given in the section above. Vero-Amlodipine and Amlodipine Pran do not have any special features, so they are used according to the above rules.

Side effects

Amlodipine can cause the following side effects from various organs and systems:

1. The cardiovascular system:

Palpitations (tachycardia);
Bradycardia (decreased heart rate);
Rhythm disturbance (arrhythmia);
Hypotension (low blood pressure), including when moving from a sitting or lying position to a standing position;
Pain in chest;
Redness of the facial skin (hot flashes);
Extrasystole;
Migraine.

Nervous system:

Fatigue;
Headache;
Dizziness;
Drowsiness;
Increased fatigue;
Asthenia;
Mood swings;
Convulsions;
Fainting;
Tremor of the limbs;
Malaise;
Insomnia;
Nervousness;
Depression;
Unusual dreams;
Anxiety;
Apathy;
Agitation (state of excitement);
Amnesia (memory loss).

Genitourinary system:

Swelling in the ankles and feet;
Increased frequency of urination;
Impotence;
Painful urge to urinate;
Pollakiuria (urination in small portions, literally drop by drop);
Nocturia (frequent urination at night).

Digestive tract:

Nausea;
Vomit;
Abdominal pain;
Changing the frequency and habitual mode of bowel movements;
Constipation;
Diarrhea;
Jaundice;
Dyspeptic symptoms (belching, flatulence, feeling of heaviness in the abdomen, etc.);
Dry mouth;
Anorexia;
Gastritis;
Increased appetite;
Pancreatitis.

Respiratory system:

Dyspnea.

Musculoskeletal system:

Arthralgia (joint pain);
Myalgia (muscle pain);
Arthrosis;
Myasthenia gravis (muscle weakness);
Pain in the limbs;
Paresthesia (numbness, tingling sensation, “pins and needles”, etc.).

Skin:

Xeroderma;
Alopecia (baldness);
Dermatitis;
Purpura.

Allergic reactions:

Skin rashes;
Itchy skin;
Erythema multiforme.

9. Other:

Gingival hyperplasia;
Gynecomastia;
Deterioration of vision;
Conjunctivitis;
Pain in the eyes;
Double vision;
Xerophthalmia;
Tinnitus;
Backache;
Chills;
Increase in body weight;
Dyspnea (episodes of stopping breathing);
Nosebleeds;
Increased sweating;
Thirst;
Cold clammy sweat;
Cough;
Runny nose;
Perversion of taste;
Parosmia (impaired sense of smell, olfactory hallucinations);
Hyperglycemia (increased blood glucose levels);
Increased activity of liver enzymes - AST, ALT, alkaline phosphatase.

Contraindications for use

Currently, doctors and scientists identify relative and absolute contraindications to the use of Amlodipine. Absolute contraindications include diseases and conditions in which taking Amlodipine is strictly prohibited. Relative conditions include those in which Amlodipine can be used with caution under the close supervision of a physician.

Absolute contraindications The following diseases and conditions are associated with taking Amlodipine:

Severe hypotension (systolic pressure below 90 mmHg);
Collapse;
Cardiogenic shock;
Unstable angina (except Prinzmetal's angina);
Aortic stenosis;
Pregnancy and breastfeeding period;
Age under 18 years;
Lactase deficiency, lactose intolerance and glucose-galactose malabsorption;
Hypersensitivity or allergic reactions to any components of Amlodipine;
Allergic reactions to dihydropyridine derivatives (Nifedipine, Isradipine, Nimodipine, etc.).

Relative contraindications The following conditions require taking Amlodipine:

Liver dysfunction;
Sick sinus syndrome;
Chronic heart failure of non-ischemic origin, classes III–IV according to the NYNA classification;
Arterial hypotension (low blood pressure);
Aortic stenosis (narrowing of the aortic lumen);
Mitral stenosis (narrowing of the mitral valve);
Hypertrophic obstructive cardiomyopathy;
Acute myocardial infarction (within a month after the heart attack);
Liver failure;
Elderly age over 65 years.

Amlodipine - analogues

In the modern pharmaceutical market, analogues of Amlodipine include two groups of drugs - synonyms and, in fact, analogues. Synonyms are drugs that also contain amlodipine as an active substance. Analogues are drugs from the group of slow calcium channel blockers, which have effects similar to Amlodipine, but contain other active substances.

Synonyms of Amlodipine include the following medications:

Agent;
Amlo;
Amlovas;
Amlodak;
Amlodigamma;
Amlodil;
Amlodifarm;
Amlocard-Sanovel;
Amlong;
Amlonorm;
Amlorus;
Amlotop;
Kalchek;
Cardilopin;
Karmagip;
Corvadil;
Cordy Core;
Norvadin;
Norvasc;
Normodipine;
Omelar cardio;
Stamlo M;
Tenox.

Analogues of Amlodipine The following medications are:

Adalat solution for infusion;
Adalat SR tablets;
Zanidip-Recordati tablets;
Zanifed capsules;
Calcigard retard tablets;
Cordafen tablets;
Cordaflex and Cordaflex RD tablets;
Cordipin, Cordipin retard, Cordipin HL tablets;
Corinfar, Corinfar retard and Corinfar UNO tablets;
Lacipil tablets;
Lerkamen 10 and Lerkamen 20 tablets;
Nicardia tablets;
Nimopin tablets and solution for infusion;
Nimotop tablets and solution for infusion;
Nifedicap capsules;
Nifedipine dragees, tablets;
Nifecard HL tablets;
Octidipine tablets;
Osmo-Adalat tablets;
Plendil tablets;
Sakur tablets;
Felodip tablets;
Felodipine tablets;
Felotenz retard tablets;
Phenigidine tablets;
Foridon tablets and solution for injection;
EsCordi Cor tablets.

Amlodipine - reviews

Most of the reviews about Amlodipine (from 80% to 90%) are positive, which is due to a noticeable positive effect on the course of existing

heart disease

or arterial hypertension. In most cases, people take Amlodipine for arterial hypertension in order to reduce and maintain blood pressure within normal limits. Reviews indicate that the drug gently and effectively reduces

arterial pressure

Eliminates noise in the head, is well tolerated and allows you to maintain performance and good health. People consider several characteristics of the drug to be advantages that distinguish Amlodipine from other antihypertensive drugs - firstly, it can be used by the elderly, secondly, it is easy to take (once a day) and the duration of the therapeutic effect.

Negative reviews about Amlodipine are few and are due to two main factors - ineffectiveness in this particular case and poor tolerability due to the severe severity of side effects. Most often in negative reviews it is noted that Amlodipine causes drowsiness, lethargy and apathy, which are very poorly tolerated because they do not allow a person to lead a normal lifestyle.

Amlodipine – price

The cost of Amlodipine can vary significantly depending on the manufacturer of the drug. Thus, drugs produced by the Israeli corporation Teva or the Swiss Sandoz are quite expensive, while Amlodipine, produced by Russian pharmaceutical factories, on the contrary, is very cheap. Unfortunately, the quality and effectiveness of Amlodipine from different manufacturers also varies greatly. Therefore, if Amlodipine from any manufacturer turned out to be ineffective or caused side effects, then it makes sense to purchase a drug from another company, since it can be an excellent medicine.

Currently, the cost of Amlodipine from various manufacturers in pharmacies in Russian cities varies within the following limits:

Tablets 5 mg, 20 pieces – 51 – 109 rubles;
Tablets 5 mg, 30 pieces – 34 – 209 rubles;
Tablets 5 mg, 60 pieces – 83 – 124 rubles;
Tablets 5 mg, 90 pieces – 113 – 174 rubles;
Tablets 10 mg, 20 pieces – 71 – 167 rubles;
Tablets 10 mg, 30 pieces – 60 – 281 rubles;
Tablets 10 mg, 60 pieces – 113 – 128 rubles;
Tablets 10 mg, 90 pieces – 184 – 226 rubles.

ATTENTION! The information posted on our website is for reference or popular information and is provided to a wide range of readers for discussion. Prescription of medications should be carried out only by a qualified specialist, based on the medical history and diagnostic results.

The fact is that this drug begins to act 5-6 hours after taking it and lowers blood pressure for a long time. Therefore, there is no need to expect it to decrease immediately.

Amlodipine has many side effects and should not be taken unless prescribed.

Most often it causes swelling, but this does not mean that the drug is not suitable for you. Many doctors think this is normal.

5 mg per day of this drug is prescribed if the pressure remains consistently high for a long time (more than 170/100).

But when the pressure stabilizes, the dose of Amlodipine should be gradually reduced and switched to weaker drugs.

Amlodipine can be taken for a long time. The drug is effective until 50 hours. Unusual duration of action. How to prescribe? The first obvious answer is once every 2 days. The patient will most likely get confused and mix up the days. Therefore, it was decided to prescribe the drug every day at half the dose. Dose 10 mg, respectively - half dose - 5 mg. Many patients refuse to accept lifelong use of the drug, believing in recovery. When taking this drug, the blood pressure normalizes and they stop taking pills. Having stopped drinking Amlodipine, patients will not feel worse for another 3-4 days, since the drug is eliminated for a long time, the remains of the drug in the blood will maintain more or less normal blood pressure. It is imperative to convince the patient to take Amlodipine daily. If you missed a dose once, it’s no big deal, take it again.

The medicine Amlodipine is used to lower blood pressure. To answer your question, you should refer to the official instructions for the drug Amlodipine, which you can read on this resource.

Hello! I can’t understand the expression - gradually reduce the dose of the drug. Mom takes 1 tablet (5 mg) at night. That's what the doctor ordered. At the moment, my mother’s blood pressure is stable at 130/70. And sometimes it’s 117/50. The doctor warned me that I shouldn’t suddenly stop taking the drug. Reduce the dose, does this mean taking 2.5 mg? How many days? And after how many days can you stop taking amlodipine? We once tried to quit gradually. The dose was reduced to 2.5 mg for 10 days. Then take it every other day for another 10 days. And then they stopped altogether. After 2 days, my mother’s blood pressure jumped to 230/110. The ambulance said - under no circumstances stop taking this drug. What to do?

Hello, please tell me, is it possible to take amlodipine in two doses - half the dose in the morning and the second half of the daily dose in the evening? The doctor prescribed me amlodipine 10 mg, Nebilet 5 mg, preducted 35 mg all in the morning. A month later, the blood pressure more or less returned to normal and he reduced the dose of amlodipine to 5 mg and prescribed it in the evening along with the evening dose of preductal. Before this, blood pressure rose to 170 to 110 mm, pulse to 90 beats. Was. Blood pressure rose along with heat in the face and rapid pulse. Now the pulse during treatment is 60 beats per minute, but blood pressure rises to 140 to 97 again. Should I start taking amlodipine 10 mg again, divided into morning and evening? Please advise! In addition to these drugs, I take Ladasten 1 tablet. Twice a day and climalanin 400 twice. The ECG at the MOMENT OF THE ATTACK showed, as the doctor said, the ejection of blood from the heart was weakened, as he explained. Is it possible to take adelfan or capoten with these drugs if the blood pressure rises? Thank you.

This medication is available in the form of tablets that contain the main active substance – amlodipine besilate. In addition to it, the medicine also contains auxiliary components, namely:

lactose; calcium stearate; croscarmellose sodium.

Most often, Amlodipine is used to normalize blood pressure. For what blood pressure should the medicine be used? It is taken by people suffering from hypertension. The drug is also prescribed for the following diseases and ailments:

treatment of hypertension at the initial stage of development; with irregular, single surges in blood pressure; with stable angina; with spasms of blood vessels.

Important to remember! Before using Amlodipine, you should consult a specialist! Only he can prescribe the drug, because self-treatment can cause complications, and if the dosage is incorrect, unpleasant side effects.

IT IS IMPORTANT TO KNOW!

A remedy that will relieve you of HYPERTENSION in a few steps

During the period of admission, you should monitor your weight and also see a dentist. The medicine may cause excess weight or severe bleeding gums. Do not stop taking the drug abruptly. This may renew the episodes of high blood pressure, and a high pulse may also occur. During the treatment period, it is better for people whose professional activities involve increased care and responsibility to take a vacation. Since this drug causes constant drowsiness or dizziness. Patients with liver failure should take Amlodipine under regular supervision of a specialist.

The relatively low cost of the drug allows it to be used by all segments of the population. But, nevertheless, you should consult a specialist before use.

Depending on the problems with blood pressure, the dosage is prescribed differently, namely:

Infrequent increases in blood pressure. This indicator can be reduced by taking 1 tablet once a day. When should you take the drug: morning or evening. It is better to take the tablet in the morning, as it begins to act after a couple of hours. If there is no improvement in the condition, you need to increase the dosage to 2 tablets per day, taking them once. With long-term use of the drug, the dose should be reduced to 0.5 tablets per day. The course of treatment lasts 1 week. An increase in duration can only be prescribed by a specialist. Arterial hypertension. People suffering from this disease need to take Amlodipine 0.5 tablets per day. This treatment has a supportive effect on the body. You should take the drug in this mode constantly. Impaired functioning of the cardiovascular system. For heart disease, experts recommend taking 1 tablet once a day. If improvement is not observed for a long period of time, then you can increase the dose to 2 tablets for a while. How long should I take this drug? Most often, doctors recommend using it on an ongoing basis for heart problems.

As an effective medicine for hypertension.

It is advised to take the drug “Hypertension”.

This natural remedy, which affects the cause of the disease, completely preventing the risk of heart attack or stroke. Hypertonium has no contraindications and begins to act within a few hours after its use. The effectiveness and safety of the drug has been repeatedly proven by clinical studies and many years of therapeutic experience.

Doctors' opinion..."

Important to remember! The duration of treatment with Amlodipine is determined only by a specialist! The patient should regularly visit the doctor, who should evaluate the state of health during the period of this therapy and the advisability of continuing to take the pills.

From the cardiovascular system: swelling of the upper and lower extremities, pain in the heart area, shortness of breath with minor exertion, increased or decreased heartbeat. From the central nervous system: rapid fatigue, dizziness with loss of consciousness, sleep disturbances, causeless irritability, anxiety, apathy. From the functioning of the gastrointestinal tract: nausea with vomiting, pain in the lower abdominal cavity, constipation or diarrhea, constant thirst, exacerbation of gastritis.

during pregnancy, the active component of Amlodipine negatively affects the development of the fetus; breastfeeding period; for diabetes mellitus; with low blood pressure; persons under 18 years of age; with lactose intolerance; in case of individual intolerance or hypersensitivity to the components of the drug.

In addition to Norvasc, modern pharmacology offers many more drugs similar in composition and effect on the body, namely:

Duactin. This medicine is available in capsules. Prescribed for hypertension, as well as for chronic palpitations. The advantage is the minimum number of contraindications for use. Tenox. Used for severe forms of hypertension and chronic angina. The drug is not suitable for persons suffering from acute heart failure. Normodipin. In a short time it normalizes high blood pressure and improves the functioning of the cardiovascular system. Contraindicated in people who have suffered acute myocardial infarction. Emlodin. A fairly inexpensive analogue of Amlodipine. It is strictly forbidden to use in severe hypotension, as well as in cases of impaired functioning of the left ventricle.

According to statistics, about 7 million annual deaths can be attributed to high blood pressure. But studies show that 67% of hypertensive patients do not even suspect that they are sick! How can you protect yourself and overcome the disease? Dr. Alexander Myasnikov told in his interview how to forget about hypertension forever...

To obtain the effect of therapy with antihypertensive drugs, it is necessary to observe the timing of their administration. This will reduce the likelihood of side effects and make you feel good. The correct use of medications is of great importance for patients with difficult-to-control hypertension who are taking several antihypertensive drugs. Therefore, you need to figure out when it is better to take blood pressure pills in the morning or in the evening.

Today, most cardiologists advise patients to take antihypertensive medications in the morning. After all, patients often experience increased blood pressure in the morning and normalization in the evening.

In patients who have a history of hypertension with diabetes mellitus or renal failure, these pressure fluctuations are impaired. In such cases, cardiologists recommend using antihypertensive drugs in the evening.

There is a rule for taking long-acting antihypertensive drugs. These include ACE inhibitors: Enap, Enaprylin and others. To determine the optimal time for taking it, doctors advise observing changes in blood pressure throughout the day.

If hypertension occurs mainly in the evening hours, then the medicine is taken in the morning. If your blood pressure rises in the morning, it is recommended to take ACE inhibitors (angiotensin-converting enzyme) before bed.

If hypertension occurs unsystematically, the daily dose can be divided into 2 doses in the morning and evening. For drugs short acting there is no such rule. They are taken in case of a sharp rise in blood pressure as emergency therapy.

Cardiologists have long agreed that the timing of antihypertensive medications affects their effectiveness and the incidence of side effects. After all, a morning dose can lead to nausea, dizziness and weakness throughout the day.

This issue is of particular importance for the millions of people who suffer from difficult-to-control hypertension. They are divided into 2 groups:

Patients take more than 2 antihypertensive drugs, but the pressure does not decrease to normal values. Patients whose blood pressure rises only at night. This condition is called nocturnal hypertension.

The use of new drugs to lower blood pressure for such patients leads to increased costs of therapy, side effects and undesirable drug interactions.

Scientists from Spain decided to look into this issue. A study was conducted involving 661 patients with hypertension.

Half of the patients had to take medications in the morning immediately after waking up, the rest - before going to bed. The use of a specific group of antihypertensive drugs was not required. The following were excluded from the number of subjects:

Pregnant women; Persons who have abused alcohol or drugs in the anamnesis; Patients who work at night; HIV-infected persons; Patients with diabetes mellitus and secondary hypertension.

The duration of the study was 5.4 years. Each patient underwent outpatient monitoring several times a year for 48 hours, during which doctors observed changes in blood pressure levels.

The study found that patients who took antihypertensive medications before bed had lower blood pressure during the day and during sleep. Also in this group, the risk of developing cardiovascular pathologies (heart attack, cardiac arrest) decreased, and overall mortality decreased.

Canadian scientists came to similar results. They proved that taking ACE inhibitor drugs before bedtime, indicated for hypertension or after a heart attack, increases the effectiveness of therapy several times.

If the drug was taken in the morning on an empty stomach, the effectiveness of the drug is comparable to taking a placebo. Canadian scientists have found that at night, patients with hypertension produce a hormone that causes expansion and damage to the heart. Taking ACE inhibitors before bed can reduce the activity of this substance, protecting the heart muscle.

This medication is available in the form of tablets that contain the main active substance – amlodipine besilate. In addition to it, the medicine also contains auxiliary components:

lactose;
calcium stearate;
croscarmellose sodium.

Most often, Amlodipine is used to normalize blood pressure. It is taken by people suffering from hypertension. The drug is also prescribed for the following diseases and ailments:

treatment of hypertension at the initial stage of development;
with irregular, single surges in blood pressure;
with stable angina;
with spasms of blood vessels.

Amlodipine helps lower high blood pressure and also improves the functioning of the cardiovascular system. Therefore, if a patient has a rapid heartbeat along with high blood pressure, then the drug will bring the body to a normal state.

This medicinal product contains potent substances. Therefore, during treatment with Amlodipine, you must adhere to the following rules:

During the appointment, you should monitor your weight and also see a dentist. The medicine may cause excess weight or severe bleeding gums.
Do not stop taking the drug abruptly. This may trigger renewed attacks of high blood pressure, and a high pulse may also be observed.
During the treatment period, it is better for people whose professional activities involve increased care and responsibility to take a vacation. This drug causes constant drowsiness or dizziness.
In patients with liver failure, Amlodipine should be taken under regular specialist supervision.

The relatively low cost of the drug allows it to be used by all segments of the population. However, you should consult your doctor before use.

Depending on the problems with blood pressure, the dosage is prescribed differently:

Infrequent increases in blood pressure. This indicator can be reduced by taking 1 tablet once a day. It is better to take the tablet in the morning, as it begins to act after a couple of hours. If there is no improvement in the condition, you need to increase the dosage to 2 tablets per day, taking them once. With long-term use of the drug, the dose should be reduced to 0.5 tablets per day. The course of treatment is 1 week. An increase in duration can only be prescribed by a specialist.
Arterial hypertension. People suffering from this disease need to take Amlodipine 0.5 tablets per day. This treatment has a supportive effect on the body. You should take the drug in this mode constantly.
Impaired functioning of the cardiovascular system. For heart disease, experts recommend taking 1 tablet once a day. If improvement is not observed for a long period of time, then you can increase the dose to 2 tablets for a while. How long should I take this drug? Most often, doctors recommend using it on an ongoing basis for heart problems.

If you take this drug excessively, a person may experience the following ailments:

From the cardiovascular system: swelling of the upper and lower extremities, pain in the heart area, shortness of breath with minor exertion, increased or decreased heartbeat.
From the central nervous system: rapid fatigue, dizziness with loss of consciousness, sleep disturbances, causeless irritability, anxiety, apathy.
From the gastrointestinal tract: nausea with vomiting, pain in the lower abdominal cavity, constipation or diarrhea, constant thirst, exacerbation of gastritis.

The patient may also experience problems in intimate life, painful urination, allergic rashes on the skin, and increased body temperature.

Important to remember! You should adhere to the dosage prescribed by your doctor! This will help protect the body from the above side effects.

This drug is strictly contraindicated in the following cases:

during pregnancy – the active component of Amlodipine negatively affects the development of the fetus;
breastfeeding period;
for diabetes mellitus;
with low blood pressure;
persons under 18 years of age;
with lactose intolerance, as well as hypersensitivity to other components of the drug.

Also, if a patient experiences severe allergic reactions after consuming Amlodipine, such treatment should be stopped and consult a specialist about the use of similar drugs.

In addition to Norvasc, modern pharmacology offers many more drugs similar in composition and effect on the body:

Duactin. This medicine is available in capsules. Prescribed for hypertension, as well as for chronic palpitations. The advantage is the minimum number of contraindications for use.
Tenox. Used for severe forms of hypertension and chronic angina. The drug is not suitable for persons suffering from acute heart failure.
Normodipin. In a short time it normalizes high blood pressure and improves the functioning of the cardiovascular system. Contraindicated in people who have suffered acute myocardial infarction.
Emlodin. A fairly inexpensive analogue of Amlodipine. It is strictly forbidden to use in severe hypotension, as well as in cases of impaired functioning of the left ventricle.

Regardless of the choice of a particular drug for high blood pressure, it is necessary to agree on its dosage and advisability of use with a specialist.

The drug "Amlodipine" belongs to the group of second-class calcium channel blockers. The drug has a hypotensive effect without significant fluctuations in blood pressure. Often prescribed to patients with angina pectoris to reduce the load on the blood vessels of the heart. The therapeutic agent is a good antioxidant. The active substance amlodipine, which is part of the drug, has a relaxing effect on the vascular muscles. The result is a gradual decrease in blood pressure without the development of sustained hypotension. Due to the expansion of peripheral vessels, their tone is reduced, which relieves the load on the heart. At the same time, the strength and frequency of heart contractions do not increase, so the medicine can be taken by patients with tachycardia and arrhythmia.

The principle of action of the main substance is based on its ability to block the channels of the walls of blood vessels and the myocardium, through which the level of calcium in cells is regulated. By limiting their saturation with these ions, the drug "Amlodipine" reduces the contractile activity of the vascular walls, which makes it possible to lower the pressure in them. Thanks to the prolonged rather than immediate action of the drug, the change in processes occurs gradually, without causing sudden changes in pressure and changes in the frequency and rhythm of heart contractions. This effect not only helps fight hypertension, but also alleviates angina pectoris. In addition, the drug has a weak diuretic effect and antioxidant properties.

The drug is prescribed for the following pathological conditions:

arterial hypertension at different stages of the disease (as part of complex treatment and as an independent remedy);
angina pectoris;
acute and chronic period of coronary heart disease;
in complex therapy in the treatment of bronchial asthma and heart failure.

The high effectiveness of the drug, the absence of the need to adjust doses due to the patient’s age and the presence of underlying diseases allow the drug “Amlodipine” to be widely used. Feedback from patients and statistical data from studies conducted speak in favor of prescribing the drug in a number of cases when other drugs did not have the expected effect.

The drug "Amlodipine" is contraindicated for use in cases of severe arterial hypotension, collapse and intolerance to the substances included in its composition. It is rarely prescribed to patients under 18 years of age, to persons with diabetes mellitus, chronic heart failure, and decreased liver function. Under the strict supervision of a physician, treatment with Amlodipine is carried out for acute myocardial infarction, lipid metabolism disorders, in old age, during pregnancy, and breastfeeding. The medicine has a number of side effects, which, however, are quite rare if the recommended dosages are followed. These include:

shortness of breath, swelling, redness of the skin, chest pain, arrhythmia, blood disorders;
dizziness, sleep disorders, headache, mental disorders;
disorders of the digestive system;
dermatitis, inflammation of mucous membranes.

The main differences between analogues of the drug are the degree of purification of the chemical components, the composition of additives and fillers, and the content of the active substance. The most popular substitutes for the drug are the medications “Amlodipine Teva”, “Amlodipine Prana”, “Amlong”, “Amlovas”.

The rules for taking, contraindications, and side effects of these drugs are similar to those indicated for the drug Amlodipine. Taking an analogue of the main medication to treat a disease can only be done on the recommendation of a doctor. Given the differences between supplements used by manufacturers, some drugs interact differently with other medications. A number of analogues, for example, the drug "Amlodipine Biocom", involve monitoring body weight while taking the medication and regular dental examinations (monitoring the condition of the gums).

The drug is available in tablets containing 2.5, 5 and 10 mg of the active substance. May be sold in blisters or plastic jars labeled “Amlodipine”. Reviews from patients describe the drug as a tasteless substance, similar to chalk. When treating hypertension, angina pectoris, coronary heart disease, the medicine is taken 1-2 tablets once a day in accordance with the release form and the doctor’s recommendations. The consumption of the active substance should not exceed 10 mg per day.

Some medications containing calcium may reduce the effectiveness of Amlodipine. Reviews and studies by pharmacologists indicate an increase in the toxicity of lithium preparations when combined with any analogues of an antihypertensive product. This may increase side effects. The drug is compatible with the main antihypertensive, hypoglycemic medications, nitrates, and antipsychotics. Cardiac glycosides can be used simultaneously with Amlodipine. When it interacts with inhalation anesthesia drugs, the antihypertensive effect is enhanced.

The main symptoms of an overdose of Amlodipine are severe hypotension, tachycardia, and pathological dilatation of peripheral vessels. First aid includes gastric lavage, administration of absorbent agents, symptomatic therapy, and monitoring of the heart condition. Constant monitoring of blood pressure, creation of correct position patient's body (legs on a hill), intravenous administration calcium preparations.

Amlodipine– a drug from the group of calcium channel blockers, which is used to treat hypertension and stable angina. Amlodipine is a drug for continuous use aimed at preventing attacks of angina pectoris and the progression of arterial hypertension.

I just recently started suffering from high blood pressure. Previously, even if it increased (I did not measure), it did not bring me any discomfort at all.

I consulted a doctor about this during my first hypertensive crisis, after which I was examined and treated.

Initially, I was prescribed Noriprel A, a combination drug that includes two substances: an ACE inhibitor and a diuretic.

I took Noriprel A for a very short time, because I was faced with the appearance of new unpleasant symptoms. In particular, I periodically experienced dizziness and darkened vision. I even lost consciousness several times!

Naturally, I thought that this was some kind of side effect of Noriprel, and I reported this to my doctor. It turned out that my body, for unknown reasons, reacted too strongly to the active ingredients of this drug, which was manifested by a sharp drop in pressure. Blood pressure decreased much more than was necessary as part of the treatment of hypertension.

The question arose about changing treatment, and I was prescribed Amlodipine, drug from another group ( it can also be used to prevent angina attacks). While taking Amlodipine, the blood pressure stabilized. Since then, I have been taking only this medicine to treat hypertension.

Hypotension was enough severe complication, and, moreover, a dangerous complication! Amlodipine, of course, is also far from an ideal drug, but it did not cause me such side effects. After I started taking Amlodipine, I began to experience swelling in my legs (they later disappeared) and periodic headaches. But this doesn’t seem scary to me at all.

By the way, in addition to these reactions , during treatment with Amlodipine may be observed Also:

feeling of heartbeat;
feeling of “flushing of blood to the face”;
drowsiness, dizziness;
nausea and abdominal pain;
skin rash;
pain in the limbs, a feeling of “running goosebumps” on the skin of the legs.

These side effects are quite common, but as you can see, they are not dangerous.

It is also worth mentioning that how Amlodipine interacts with other drugs.

For example, drugs for the treatment of atherosclerosis (statins, in particular) are not recommended to be taken together with many antihypertensive drugs, since their effect is significantly reduced. Amlodipine, according to my doctor, can be “mixed” with statins: I continue to take Crestor (rosuvastatin) quietly.

It turned out differently with another drug that I took earlier. My knee joints periodically hurt (for many years now!), and in such a situation Diklak has always helped me - in ointment or in tablets. This is an anti-inflammatory drug, the active substance there is diclofenac. Now I can’t take this drug, since they are not compatible with Amlodipine. I even noticed myself what the reason was: I didn’t have such stomach pains from Diklak before.

Amlodipine is combined with almost all groups of drugs for the treatment of hypertension,- this is a rather rare and very useful feature of this medicine.

Here, to the information about how and with what you can combine Amlodipine, I will add a list contraindications:

acute myocardial infarction (Amlodipine should not be taken within a month after it);
states of shock;
unstable angina (rapidly progressive).

Especially You need to be careful when using Amlodipine people who suffer:

aortic stenosis;
heart failure;
liver diseases;

Children and pregnant women this drug can be prescribed only if it is reliably known that the benefits of treatment outweigh the possible harm from it.

The most common disease - hypertension - is getting younger every year. If a couple of decades ago a third of the population of our country suffered from it, and these were mainly people aged 45 and above, now the average age of hypertension has dropped to 35. Increasingly, high blood pressure is observed in young people under 20 years of age.

What can I say! Even modern teenagers have indicators above 140 to 90. The disease is practically incurable. To support normal level blood pressure, you have to constantly take medications, of which there are a great many. Choosing the right one is the key to a full life with hypertension.

Amlodipine is one such drug. At a low cost, it has many advantages, especially when taken in combination.

Once in the human body, the drug blocks calcium channels, which lowers blood pressure and stops attacks of diseases such as angina pectoris and coronary artery disease. Having a cumulative effect that lasts throughout the day, the drug gradually lowers blood pressure, which has a beneficial effect on the well-being of patients.

According to the instructions for use, Amlodipine normalizes the walls of blood vessels and arteries without causing excitability of the middle muscular layer of the heart, scientifically the myocardium, has a mild diuretic effect and increases the body's endurance to moderate physical activity.

The medicine promotes vasodilation, supplying the heart and brain with the necessary amount of oxygen, thereby preventing hypoxia (oxygen starvation).

For patients suffering from angina pectoris, the drug is prescribed to reduce the number of attacks of the disease and their intensity.

Amlodipine has valuable properties: it normalizes blood pressure and replenishes the heart muscle with a sufficient amount of oxygen. Its hypertensive effect is achieved by dilating blood vessels and lasts for 24 hours when using a daily dose of the drug.

The contractions of the heart and the conductivity of the heart muscle do not change, but only the work of our motor is stimulated and the walls of its blood vessels are strengthened.

Why is Amlodipine prescribed and what does it help with? Indications for the use of the drug are quite extensive. It is prescribed for:

Stable high blood pressure as an independent remedy or in complex treatment;
Angina attacks that occur during physical exertion and emotional outbursts;
Angina at rest, that is, attacks of the disease that occur suddenly, without any apparent reason;
IHD (coronary heart disease), including its chronic form;
Chronic heart failure;
Bronchial asthma as a vasodilator.

The drug is indispensable in maintaining normal blood pressure for patients suffering from hypertension of degrees 1, 2 and 3, and any form of angina. It allows them to live a full life with these far from pleasant diseases.

The medicine is sold in cardboard packages with three blisters containing 10 pieces of round, beveled pills of white or slightly yellowish color in everyone. Its dosage varies - 2.5; 5 and 10 mg.

The tablets contain the active component amlodipine, as well as auxiliary components, these are:

Potato starch;
Calcium stearate;
Lactose;
Monohydrate, etc.

The drug is produced by several manufacturers. On the shelves of our pharmacies you can find medicines of the following names and manufacturers:

Vero-Amlodipine, manufactured by Veropharm JSC, whose production facilities are located in Belgorod, Voronezh and Pokrov, Moscow region;
Amlodipin-Biocom - JSC "Biocom", Stavropol;
Amlodipine-Borimed - Berezovsky Pharmaceutical Plant;
Amlodipine-Teva, produced in Israel;
Amlodipine-Prana - Pranafarm LLC, Samara;
Amlodipine-Sandoz - Germany.

The product of the same name is also produced in Nizhny Novgorod, Perm and Moscow.

For hypertension not complicated by other diseases, a single dose of 2.5 mg is prescribed.

If there are complications such as ischemia and angina, the daily dose is 5 mg.

If necessary, the dosage is increased to 10 mg per day. This is the maximum dosage of the drug.

Patients suffering from liver and kidney failure should take the medicine no more than 2.5 mg per day.

Children over the age of 6 years are prescribed 2.5 mg per day. If the desired effect does not manifest itself within four weeks, the dose is increased to 5 mg.

In old age, the dosage should be increased with caution.

Take the medicine in the morning, before meals, with a small amount of water. The dose is prescribed by the doctor. You should not self-medicate to avoid unpleasant consequences.

Amlodipine and pregnancy

The instructions for use indicate that this product is not recommended for pregnant women and nursing mothers, however, in cases where the benefits of using Amlodipine are higher than the risk to the baby, it is prescribed, but in late pregnancy.

It is known that high blood pressure during pregnancy is very dangerous for both the expectant mother and her child. If you do not reduce blood pressure in a pregnant woman, this can lead to intrauterine death of the fetus due to hemorrhage in the brain, therefore, in order to avoid fatal consequences, women in pregnancy starting from 34 weeks are prescribed Amlodipine at a dose of 5 mg.

During breastfeeding, the drug is prescribed if the mother transfers her baby to artificial feeding.

Is it possible to use the drug

Amlodipine is successfully used to lower blood pressure in patients diagnosed with diabetes mellitus (DM). The medicine contains no substances that change the concentration of glucose in the blood, so it is not contraindicated in diabetes.

Also, its antianginal and antihypertensive effect has a beneficial effect on patients in this category, relaxing the vascular muscles and reducing the load on the myocardium, thereby reducing the number and weakening the intensity of angina attacks.

Like many medications, Amlodipine has some contraindications. It is prohibited to use if:

Hypersensitivity to the components contained in it (allergic manifestations);
Low blood pressure (hypotension);
Aortic stenosis (narrowing of the aortic opening in the valve area);
Acute heart failure;
Recent myocardial infarction (less than a month ago);
Children up to 6 years of age.

The use of the drug during pregnancy and breastfeeding is discussed above.

The drug is used with particular caution in case of kidney and liver diseases, as well as in the presence of pronounced tachycardia and bradycardia.

Amlodipine is well tolerated by patients, but sometimes, when using the drug, various deviations are possible, expressing themselves:

Headaches and dizziness;
Loss of consciousness;
Depression and apathy;
Chest pain and heart attack;
Shortness of breath;
Swelling of the feet and ankles;
Nausea and vomiting;
Discomfort in the abdominal cavity;
Abnormal stool;
Extrasystole, tachycardia and palpitations;
High fatigue;
Trembling fingers;
Redness of the facial skin;
Sleep disturbance;
Sexual disorders, etc.

If, while taking the drug, at least one of the listed symptoms occurs, then taking the drug should be stopped immediately.

In case of an overdose of the drug, a sharp decrease in blood pressure is observed, accompanied by tachycardia, which is caused by excessive vasodilation. In case of drug poisoning, you should immediately call an ambulance.

If necessary, the doctor at the appointment will select medications that will go well with Amlodipine, however, it is worth remembering that:

Using the drug together with anti-inflammatory drugs reduces the activity of the liver, which can lead to intoxication and side effects;
When used simultaneously with estrogen, the hypertensive effect of the drug is reduced. The same thing happens when taking the medicine together with calcium supplements;
The combined use of Amlodipine and Orlistat provokes a rise in blood pressure;
When using the medication, it is worth reducing the dosage of diuretics, adenoblockers and antipsychotics;
The drug combines well with cardiac glycosides.

Amlodipine itself is a powerful vasodilator that lowers blood pressure, and its simultaneous use with alcohol will enhance this effect several times, which can lead to dire consequences.

The medicine is also processed in the liver, increasing the load on it. The same thing happens with ethanol. As a result of this, the liver may simply not withstand such a load, which can also end very badly for the patient.

And in general, alcohol negatively affects both the cardiovascular system and the central nervous system, so why carry out treatment if it is immediately canceled out by drinking alcohol?

Important information

When using the drug, it is worth remembering some subtleties of administration:

You should start taking the drug with a minimum dosage of 2.5 mg, and then gradually increase it to 5 or 10 mg, in accordance with the existing disease and its severity;
Under no circumstances should you suddenly stop using the medicine, but it is better to do this by gradually reducing the dose;
When using the drug, it is necessary to monitor blood pressure. If they suddenly decrease or increase, you should stop taking them and consult a doctor immediately.

The pills do not cause drowsiness and do not depress the central nervous system unless this is a side effect, so they can be safely used by people involved in driving a car.

The price of the drug depends on the number of tablets in the package, dosage, and the manufacturer. For example, the cost of 30 tablets of 5 mg of domestic production ranges from 35-50 rubles, and imported ones are an order of magnitude higher, that is, about 200 rubles. 30 pills of 10 mg each cost: from our manufacturers - about 150 rubles, and imported ones - 250-300 rubles.

The most popular analogues of the drug are Normodipin, Cardilopin, Amlovas and Norvasc.

Many patients wonder which drug is better, Normodipine or Amlodipine? Experts will tell you that the first one is produced by the famous pharmaceutical company Gedeon Richter, and also does not have as many side effects, but it is an order of magnitude higher than the cheap Amlodipine.

But it does not eliminate the side effect of swelling of the feet, so if swelling occurs, it is worth replacing these drugs with others, for example, Lisinopril.

In any case, if the medicine needs to be changed to another, you do not need to do it yourself, but it would be best to seek advice from a specialist.

Victor, 49 years old.

“I came to see a doctor when my blood pressure began to go through the roof. He prescribed me Amlodipine. At first I took 2.5 mg of the drug, and after a couple of weeks the doctor increased the dosage to 5 mg. I spent a little over a year on treatment. The result is simply magnificent. The pressure returned to normal, the tinnitus went away, and the dizziness stopped. I continue to take it now. Thank God, I did not experience any side effects from the medicine. I am very pleased with this product!”

Maria, 30 years old.

“My mother’s blood pressure has been fluctuating for a long time. At the clinic, in addition to other medications, she was prescribed Amlodipine. I started taking it with a minimum dose, after 6 months the doctor said that the dose could be increased. He has been taking the drug for 2 years. The pressure surges stopped. Not that it has returned to normal, but at least it has become stable, and does not rise above 160 to 90. Mom began to feel much better, and in the two years that she took the medicine, she never had hypertensive crisis. And all this thanks to an amazing medicine!”

Olga, 55 years old.

“I’ve only been taking the drug for a few days, but during this time my health has noticeably improved. The pressure dropped to 140 over 80, the headaches and tinnitus disappeared. No more dizziness. I would have liked the effect of Amlodipine if my legs had not started to swell. I read the instructions for use, and it says that this phenomenon can be a side effect. Tomorrow I will go to the doctor for a consultation. It’s a shame if the drug is canceled for me, I really liked it!”

In this age of modern technology, the burden on our health is great. You have to work a lot, and overwork does not lead to anything good, which is why all sorts of ailments arise, such as hypertension and other diseases associated with it. This drug copes with its task perfectly, and this has been proven.

Health to you and your family!

Contents [Show]

lactose; calcium stearate; croscarmellose sodium.

treatment of hypertension at the initial stage of development; with irregular, single surges in blood pressure; with stable angina; with spasms of blood vessels.

IT IS IMPORTANT TO KNOW!

A remedy that will relieve you of HYPERTENSION in a few steps

As an effective medicine for hypertension.

It is advised to take the drug “Hypertension”.

This is a natural remedy that acts on the cause of the disease, completely preventing the risk of heart attack or stroke. Hypertonium has no contraindications and begins to act within a few hours after its use. The effectiveness and safety of the drug has been repeatedly proven by clinical studies and many years of therapeutic experience.

Doctors' opinion..."

If hypertension occurs unsystematically, the daily dose can be divided into 2 doses in the morning and evening. There is no such rule for short-acting drugs. They are taken in case of a sharp rise in blood pressure as emergency therapy.

This issue is of particular importance for the millions of people who suffer from difficult-to-control hypertension. They are divided into 2 groups:

The use of new drugs to lower blood pressure for such patients leads to increased costs of therapy, side effects and undesirable drug interactions.

Scientists from Spain decided to look into this issue. A study was conducted involving 661 patients with hypertension.

Pregnant women; Persons with a history of alcohol or drug abuse; Patients who work at night; HIV-infected persons; Patients with diabetes mellitus and secondary hypertension.

The duration of the study was 5.4 years. Each patient underwent outpatient monitoring several times a year for 48 hours, during which doctors observed changes in blood pressure levels.

When to take amlodipine in the morning or evening

In chapter Diseases, Medicines to the question When is it better to take drugs that lower arterial blood pressure? pressure - in the morning or in the evening? given by the author Alexander Kudryavtsev OLD. OTVET the best answer is There is a so-called circadian rhythm of blood pressure, i.e. fluctuations in blood pressure during the day. For example, for patients whose high blood pressure is more often recorded in the morning, a drug that lowers blood pressure is prescribed at night in order to prevent a peak rise in pressure in the morning. Daily medications can be prescribed at any time of the day - they will still “work”, but the circadian nature of the increase in blood pressure must be taken into account. Amlodipine works better at night, but this does not mean that it cannot be prescribed in the morning or during the day - everything is individual. If several long-acting medications are combined, they are usually prescribed at different times so that their effect is not cumulative and blood pressure does not decrease more than necessary. I don’t agree with Dmitry Petrov about “stupid questions.” The patient must know everything about his disease and the drugs used to treat him; believe me, the instructions do not cover all the details, and who else but a doctor will “sort everything out” for him?
Original source cardiologist Badykin Dmitry

Thinker
(5817)
Well, why fantasy? If it is difficult to get to a doctor, it is not the doctor’s fault. I spend 25-30 minutes with one patient and we have enough time to listen to each other. I hand over all the recommendations to him, the only thing I ask is that he doesn’t forget to take them next time. Whoever wants to be treated is treated in good faith. I won’t force anyone to come to me if they don’t want to. Find yourself your “expert”, whom you can contact without skepticism and mistrust, and the problem of the quality of treatment will be closed

2 answers

Hello! Here is a selection of topics with answers to your question: When is the best time to take arterial blood pressure medications? pressure - in the morning or in the evening?

Answer from Oliya Rudakova (Repyeva)
In the morning.

Answer from Dmitry Petrov
It depends on what kind of drugs they are. There are some that you need to drink several times a day. If only once, then usually in the morning. In general, for each drug you need to read the instructions, everything is written there and don’t ask stupid questions

Answer from Elmir Boyko
If they are long-lasting, then it doesn’t matter, but only always at the same time, for example, it’s convenient for me at 2-3 o’clock in the afternoon.

Answer from ?Galina Zhigunova?
Alexander, in general, a doctor should select antihypertensive drugs, after which he usually describes when and what kind to take. You should always monitor your blood pressure (morning and evening), and if it is elevated, take it immediately. Therefore, there will be no restrictions in the morning or evening.

Answer from Yin Yang
It depends on what medications. Personally, I prefer to clean the blood vessels and not bother and be independent of anyone or anything. The peak of the rise is considered to be at about 6 o'clock in the morning. Blood pressure and temperature and pulse rise at this time, heart attacks often occur. But this is general. and everyone should know about themselves beloved.

Answer from Alexander Chebotarev
I don't think there is a single correct review. For 15 years, when diagnosed with hypertension, no one prescribed the correct therapy...

Answer from Natasha Klygina
Guys, girls, who took temozolomide, how to take it

Answer from Yergey Mishchenko
at any time and regardless of meals

2 answers

Hello! Here are more topics with the answers you need:

This medication is available in the form of tablets that contain the main active substance – amlodipine besilate. In addition to it, the medicine also contains auxiliary components, namely:

lactose;
calcium stearate;
croscarmellose sodium.

treatment of hypertension at the initial stage of development;
with irregular, single surges in blood pressure;
with stable angina;
with spasms of blood vessels.

This medicinal product contains potent substances. Therefore, during treatment with Amlodipine, you must adhere to the following rules:

During the period of admission, you should monitor your weight and also see a dentist. The medicine may cause excess weight or severe bleeding gums.
Do not stop taking the drug abruptly. This may renew the episodes of high blood pressure, and a high pulse may also occur.
During the treatment period, it is better for people whose professional activities involve increased care and responsibility to take a vacation. Since this drug causes constant drowsiness or dizziness.
Patients with liver failure should take Amlodipine under regular supervision of a specialist.

The relatively low cost of the drug allows it to be used by all segments of the population. But, nevertheless, you should consult a specialist before use.

Depending on the problems with blood pressure, the dosage is prescribed differently, namely:

Infrequent increases in blood pressure. This indicator can be reduced by taking 1 tablet once a day. When should you take the drug: morning or evening. It is better to take the tablet in the morning, as it begins to act after a couple of hours. If there is no improvement in the condition, you need to increase the dosage to 2 tablets per day, taking them once. With long-term use of the drug, the dose should be reduced to 0.5 tablets per day. The course of treatment lasts 1 week. An increase in duration can only be prescribed by a specialist.
Arterial hypertension. People suffering from this disease need to take Amlodipine 0.5 tablets per day. This treatment has a supportive effect on the body. You should take the drug in this mode constantly.
Impaired functioning of the cardiovascular system. For heart disease, experts recommend taking 1 tablet once a day. If improvement is not observed for a long period of time, then you can increase the dose to 2 tablets for a while. How long should I take this drug? Most often, doctors recommend using it on an ongoing basis for heart problems.

If you take this drug excessively, a person may experience the following ailments:

From the cardiovascular system: swelling of the upper and lower extremities, pain in the heart area, shortness of breath with minor exertion, increased or decreased heartbeat.
From the central nervous system: rapid fatigue, dizziness with loss of consciousness, sleep disturbances, causeless irritability, anxiety, apathy.
From the functioning of the gastrointestinal tract: nausea with vomiting, pain in the lower abdominal cavity, constipation or diarrhea, constant thirst, exacerbation of gastritis.

The patient may also experience problems in intimate life, painful urination, allergic rashes on the skin, and increased body temperature.

Important to remember! You should adhere to the dosage prescribed by your doctor! This will help protect the body from the above side effects.

This drug is strictly contraindicated in the following cases:

during pregnancy, the active component of Amlodipine negatively affects the development of the fetus;
breastfeeding period;
for diabetes mellitus;
with low blood pressure;
persons under 18 years of age;
with lactose intolerance;
in case of individual intolerance or hypersensitivity to the components of the drug.

Also, if a patient experiences severe allergic reactions after consuming Amlodipine, such treatment should be stopped and consult a specialist about the use of similar drugs.

In addition to Norvasc, modern pharmacology offers many more drugs similar in composition and effect on the body, namely:

Duactin. This medicine is available in capsules. Prescribed for hypertension, as well as for chronic palpitations. The advantage is the minimum number of contraindications for use.
Tenox. Used for severe forms of hypertension and chronic angina. The drug is not suitable for persons suffering from acute heart failure.
Normodipin. In a short time it normalizes high blood pressure and improves the functioning of the cardiovascular system. Contraindicated in people who have suffered acute myocardial infarction.
Emlodin. A fairly inexpensive analogue of Amlodipine. It is strictly forbidden to use in severe hypotension, as well as in cases of impaired functioning of the left ventricle.

Regardless of the choice of a particular drug for high blood pressure, it is necessary to agree on its dosage and advisability of use with a specialist.

When selecting a medication for arterial hypertension (AH) for a patient, doctors often choose Amlodipine and medications with a similar composition.

The instructions for use call amlodipine a medication with antianginal (anti-ischemic) and hypotensive (antihypertensive) action, which allows the use of this drug in the treatment of hypertensive patients with concomitant ischemic diseases. We suggest that you familiarize yourself with the rules for taking Amlodipine tablets and other information related to this medication.

Composition and mechanism of action

According to the instructions for use of the drug Amlodipine, it contains the only active ingredient - amlodipine besilate. The list of auxiliary components, in addition to magnesium and calcium salts, starch and cellulose, contains milk sugar (lactose) - a carbohydrate that can cause an intolerance reaction in people predisposed to this.

In the drug Amlodipine, the mechanism of action of the active substance is based on complementary effects:

blockade of calcium channels;
dilation of blood vessels - coronary (heart) and periphery;
reducing capillary resistance;
reducing preload on the myocardium and its oxygen demand.

All this helps to reduce the severity of hypertension and ischemia of the heart muscle.

Pharmacological group

The instructions for use indicate the pharmacological group of Amlodipine - (BMKK), as stated in the document, of the second generation. This indicates such characteristics of the drug as:

a longer half-life of the drug from the blood (and therefore a longer duration of action);
higher level of tissue specificity of the drug;
fewer side effects.

Such qualities make it possible to obtain high results from the use of the drug Amlodipine with a minimum of side effects. At least this is what the instructions for use say.

Most medications from the BMCC group have a mild diuretic effect.

Release form

Manufacturers of the drug Amlodipine have chosen the most popular and convenient form of release for patients - tablets. They are usually produced in the form of flattened cylindrical pills in various shades of cream, yellow, pink and white flowers in dosages of 5 and 10 mg.

Which manufacturer is better?

As stated in the complete drug reference book, amlodipine is the basis of a medication that is produced in Germany and is called Norvasc.

When evaluating Amlodipine - which manufacturer is better - reviews often speak in favor of the German drug. But many patients respond positively to Amlodipine, produced in Hungary, Serbia, Belarus, India, Macedonia and the Russian Federation.

Perhaps the whole point is in the individual tolerability of this medicine or in the correct selection of the dose and adherence to the dosage regimen, but it is not easy to select from the manufacturers of Amlodipine which is better. Although you can focus on aspects that do not raise doubts - the more famous the pharmacological company, the usually better quality its products, but the cost of these products can be tens of times higher.

What does it help with and why is it prescribed?

Considering the pharmacodynamics of the drug Amlodipine, what this medication helps with is not difficult to understand. It has antihypertensive and antiischemic effects, which means it helps against hypertension and, one of the manifestations of which is. These diseases require prolonged therapy, for which Amlodipine is prescribed.

Indications

This is also stated in the instructions for use in the section on indications. The list of indications for the use of Amlodipine indicates:

AG - for therapy both in combination with other hypotonic medications, and as an independent drug;
stable angina pectoris;
vasospastic angina (or Prinzmetal), or vasospastic (as a single drug or in combination with certain anti-ischemic medications).

Manifestation of stable angina pectoris

At what pressure should I take it?

Since the medication has vasodilating properties, it is worth asking at what pressure Amlodipine is recommended for use according to the instructions for use. But this document does not name specific blood pressure values at which treatment with blood pressure tablets Amlodipine is indicated. If we focus on the indications for use, then arterial hypertension is one of the indications for the use of this drug. However, only a specialist can determine whether a patient has arterial hypertension.

You should consult a doctor, who will decide which drug is appropriate in a particular case, at what pressure to take Amlodipine according to the instructions for use for you personally.

Instructions for use

Let's look at other information offered by the instructions for Amlodipine. In what doses, at what time and how to take Amlodipine with high blood pressure, as well as other information.

How to take these tablets?

There is nothing unusual in how to take Amlodipine - the tablet is swallowed whole and washed down with water. It is not necessary to crush the pill, except in situations where a dosage of 2.5 mg is required for initial therapy (for hypertensive patients with impaired liver function).

Before or after meals?

Patients often ask how to take Amlodipine - before or after meals. Although the annotation for Amlodipine says that taking the medicine does not depend on food intake, apparently this point needs clarification.

You can take the medication before, during, and after meals.

In the morning or evening?

There is no attachment to the time - when to take Amlodipine, in the morning or in the evening. The pill is taken once a day (preferably at the same time) and each patient can choose a convenient moment for use independently, taking into account the diuretic effect of the medication.

Dosage

The issue of Amlodipine dosage is of particular importance given the pronounced hypotensive effect of the drug.

The required starting dose should be selected by the attending physician. When treating hypertension, it is usually 5 mg, for which Amlodipine 5 mg tablets are prescribed.
You should neither stop taking the medication nor increase its dosage without consulting your doctor. It will be possible to switch to a therapeutic dose (10 mg) no earlier than 14 days after the start of treatment.

Amlodipine 5 mg tablets, instructions for use suggest dividing them in half to obtain the starting 2.5 mg. This dosage is necessary for patients with liver dysfunction.

How long does it take for it to start working?

The instructions for use of Amlodipine indicate how long after the taken medication begins to act - after 2–4 hours. The therapeutic effect of the tablet lasts 1 day.

How long can I take it without a break?

Patients are also interested in information such as how long Amlodipine can be taken without interruption. There is no universal answer here, since the period of continuous use of antihypertensive tablets is determined by the attending physician individually. But patients with hypertension should prepare to take pills constantly. Instructions for use indicate the absence of a “withdrawal syndrome” in Amlodipine (a sharp rise in blood pressure and the manifestation of other symptoms when the drug is discontinued). However, it is recommended to stop taking it gradually, by gradually reducing the dosage over 5-7 days.

Degrees of arterial hypertension

Contraindications

You should familiarize yourself with the list of contraindications for Amlodipine before starting therapy with this medicine, since the side effects of Amlodipine that arise as a result of non-compliance with contraindications pose a danger to the patient’s life. It is forbidden to use these tablets if:

hypersensitivity to any of the ingredients, including auxiliary ones;
bearing a child and breastfeeding;
severity of aortic stenosis;
unstable angina (except for vasospastic);
cardio shock;
state of collapse of any etiology;
significant (SBP< 90).

Due to the lack of clinical studies, use this medication age group under 18 years of age is also prohibited.

During pregnancy

There is also separate information on the use of Amlodipine during pregnancy in the official instructions for use. It is explained here that in studies on a control group of animals, the drug showed neither teratogenicity (structural changes leading to deformities in intrauterine development) nor embryotoxicity (toxic effects on the fetus). However clinical experience It is not used in pregnant or lactating women. Therefore, the instructions for use warn against use not only by these groups of patients, but also by all women of reproductive age with a high risk of unplanned pregnancy.

Side effects

Instructions for use warn of the risk of development during drug therapy Amlodipine side effects. Most often they occur when contraindications are not observed, but may not depend on this factor. Undesirable effects occur with varying frequencies, so it is more clear to depict their effects in a table.

Table. What are the undesirable effects of Amlodipine therapy?

Often	Infrequently	Rarely	Occasionally
In the heart and vascular system: swelling of the extremities, rapid heartbeat	Marked drop in blood pressure, orthostatic hypotension	The emergence or worsening of CHF	Arrhythmic disorders (atrial fibrillation, bradycardia, etc.)
In the respiratory system: no frequent	Shortness of breath, rhinitis	No	Cough
In the hematopoietic system: no frequent		No	Thrombocytopenia, leukopenia and other disorders
In the central nervous system: excessive fatigue, dizziness, headache	Anxiety, depression, strange dreams, emotional lability, asthenia, etc.	Apathy, convulsions	Amnesia, ataxia (motility disorder)
In the gastrointestinal tract: nausea, abdominal (stomach) pain	Vomiting, other dyspeptic disorders, thirst	Increased appetite	Hepatitis, increased transaminase activity, inflammation of the pancreas or gastric mucosa
In the genitourinary system: no frequent	Painful urge to urinate, impotence	No	Increased urination (up to 1.8 liters per day) or, conversely, difficulty urinating
In the musculoskeletal system: no frequent	Pain in the muscles and back, seizures, arthrosis	An autoimmune disease, a pathological muscle fatigue called myasthenia gravis	No

In addition to those indicated in the table unwanted effects Their infrequent manifestations include:

Problems skin in the form of rashes, itching, dermatitis, extremely rarely - the development of angioedema and others allergic reactions;
gynecomastia (enlarged mammary glands in men);
hyperglycemia (increased blood glucose levels);
conjunctivitis and other eye diseases;
pronounced change in body weight;
increased sweating and others, full list which contains official instructions by application.

If undesirable effects occur, you should consult your doctor about the possibility of replacing Amlodipine with analogues of the drug.

Compatibility of the drug with alcohol

The instructions for use do not address the issue of Amlodipine and alcohol. The compatibility of these substances is impossible due to their synergistic effect on the body. Alcohol has a psychotropic effect, slows or increases heart rate, and causes a slight decrease in blood pressure. But this is immediately after taking it.

In the process of assimilation of alcohol, ethanol has a toxic effect on the heart muscle, promotes lipid deposition in myocardial cells, deterioration of its contractile function, and vasospasm. All this leads to arrhythmic disorders, increased blood pressure and other consequences that neutralize treatment with Amlodipine tablets. Alcohol is in no way compatible with them.

Recipe in Latin

Since we are talking about a medication sold by prescription in pharmacies, it would be useful to familiarize yourself with what the prescription for Amlodipine looks like in Latin:

Rp: Tab. Amlodipini 0.005 (0.010)

D.t. d: No. 30 (or No. 10) in tab.

S: 1 tablet 1 time per day.

Doctors have to write so much that only a pharmacy worker can decipher their handwriting. But now patients will be able to figure out what is written in the prescription: on the top line is the international name of Amlodipine in Latin in the genitive case, the second line is the number of tablets in the package, the third is the method of administration.

Reviews from patients who took the drug

Analysis of reviews about Amlodipine is unlikely to please the manufacturers of this medication. In contrast to the assessments of doctors, who are distinguished by restraint, the opinions of patients were divided into diametrically opposed ones.

Among those who took Amlodipine according to the instructions for use, there are practically no people who consider the medication to fully comply with the information contained in the instructions. For example, they write that Amlodipine is not indicated for use during a hypertensive crisis, but patients noticed that this medicine very quickly, and most importantly, significantly reduces blood pressure.
There are no reviews about the compatibility of Amlodipine and alcohol, which indicates the literacy of patients taking antihypertensive drugs. There can be no talk of any such combination.
A small proportion of patients named Amlodipine as an integral part of their daily medication list. They use these pills as prescribed by the doctor after individually selecting the dose of amlodipine. Reviews from patients who took the drug according to an individually selected regimen are usually positive.
Most of the patients who have tried this BMCC on themselves are dissatisfied with the severity of the side effects. The most common are: fatigue, severe general malaise, problems with the eyes and joints. Some patients call this medication a “terrible drug.”
Negative reviews are also caused by such side effects as itchy skin and rashes. After such undesirable manifestations, patients switched to the drug amlodipine under the trade name Norvasc, which was much better tolerated by them.

By the way, doctors write about the same thing. They point out the questionable quality of the medicine, which is 100 times cheaper than the original.

What is the difference and which is better for reducing blood pressure?

What drug should hypertensive patients choose? Most right choice Your doctor will help you do this. But if in this case it turns out that the medication is not suitable for you, what can you replace Amlodipine with? There are several dozen options for replacing and analogues of Amlodipine.

Korean-made white or pinkish Amzaar tablets are a combination of two active ingredients - amlodipine and losartan, respectively BMCC and an angiotensin II inhibitor.

This is a significant difference between the medication and the one under consideration, since complex treatment is traditionally considered more effective. The medication is one of the newest high-quality antihypertensive drugs, as evidenced by its high price, but is not a direct analogue of Amlodipine.

White or cream-colored oblong tablets Amlodipine-Prana are produced in the Russian Federation and are a direct substitute for Amlodipine, containing only this active substance in their composition. This is one of the cheapest options for Amlodipine that can replace the original drug.

Easily recognizable by their appearance, white round Amlodipine-Teva tablets are produced by the Hungarian branches of the Israeli pharmaceutical enterprises Teva. You can recognize them by the engraving on one of the sides - “AB 5” (or 10, depending on the dosage of the active ingredient in the pill). This is a direct substitute for the medicine in question.

The Russian drug Amlorus is also a structural substitute for Amlodipine. It is a white, flattened, cylindrical tablet. Amlorus is available in three dosages: 2.5 mg, 5 mg and 10, which is convenient for patients with impaired liver function who are indicated for small doses, especially at the initial stage of therapy.

Similar to Amlorus and other Russian pills from Amlotop. They are available in dosages of 5 and 10 mg and look like flattened cylindrical pills with a score in the middle. The excipients also contain lactose, as the instructions for use warn about. They are a direct analogue of Amlodipine.

Another Russian drug, produced in dosages of 5 and 10 mg, is Aprovask. These are whitish cylindrical pills, flattened and divided by a groove in the middle. The composition contains milk sugar and other auxiliary components, which are not much different from the ingredients of similar medications.

The Russian combination medicine Vamloset is interesting for its composition. It contains amlodipine (a calcium channel blocker) and valsartan (an angiotensin II enzyme blocker) and is available in five dosages:

5 + 80 mg (round yellowish-brown pills);
5 + 160 mg (oval brown-yellow);
5 + 320 mg (orange-brown capsules);
10 + 160 mg (oval brown-yellow);
10 + 320 mg (brown-yellow capsules).

Dosage variability facilitates more careful individual selection of doses for the treatment of arterial hypertension. This disease is indicated in the instructions for use as the only indication for the use of Vamloset.

Feature Russian tablets Vero-Amlodipine is free of lactose from the auxiliary components, so patients with intolerance to this carbohydrate can be treated with this medication. In all other respects, the drug is similar to the original one.

The active ingredients of Russian-made Dalneva tablets are amlodipine and perindopril (). Available in dosages:

5 + 4 mg - round whitish tablets;
10 + 4 mg - white or whitish convex capsule-type tablets with a score on one side;
5 + 8 mg - white tablets, convex on both sides;
10 + 8 mg - whitish tablets with a score on one side.

This combination product does not contain lactose.

A structural analogue of Amlodipine made in India, Kalchek, also does not contain lactose as excipients. This means that it can be safely used in the treatment of patients intolerant of this carbohydrate. Kalchek tablets are round in shape and white in color.

The Hungarian structural analogue of Amlodipine is flat white or yellowish flattened round-shaped tablets Cardilopin. They are available in three dosage options, as evidenced by the engraving on the surface of the tablets:

2.5 mg - embossed “251”;
5 mg - “252” engraved;
10 mg - number “253”.

On the side opposite the numbers on tablets with any dosage, an “E” is engraved.

Ko-Dalneva’s drug is also intended for the treatment of arterial hypertension. No other indications are indicated in the instructions for use of the drug. This is a combined antihypertensive drug consisting of the BMCC amlodipine, the diuretic indapamide and the ACE inhibitor perindopril erbumine. Available in several dosages and does not contain lactose.

Another combination drug produced by the Swiss company Novartis is also available in a polyvariant dosage of three active ingredients: amlodipine, valsartan () and hydrochlorothiazide (diuretic). In the instructions for use, the only indication for use is arterial hypertension; there is no lactose in the composition.

The active ingredients of the Russian drug Lortenza are amlodipine and the angiotensin II receptor antagonist losartan. The tablets are available in several dosage options and have the form of oval pills ranging from white and light yellow to reddish-brown.

When patients ask which is better, Amlodipine or Norvasc, there is only one answer - Norvasc is an original drug with active substance amlodipine. It is produced in Germany and its quality and effectiveness are beyond doubt.

However, the price of this drug is quite high, so not all patients can afford prolonged therapy with this drug.

White, oblong-round tablets of Normodipine contain one active ingredient and are marked with “5” or “10” embossed, depending on the dosage. If you compare Normodipine and Amlodipine, what is the difference, there are not too many differences. One of the few is the absence of lactose in the auxiliary ingredients.

White Prestance tablets have various geometric shapes (including triangular and square) and engraving indicating the dose (4 options in total) of the active ingredients - amlodipine and perindopril - on one surface. The opposite side is occupied by the manufacturer's logo.

According to the instructions for use, amlodipine and telmisartan (angiotensin II receptor antagonist) are the main components of the German drug Twynsta. These are oval tablets, two-layer (white and blue-gray), not coated, smooth on one side and marked “A1” - “A4” on the other. Intended for the treatment of hypertension.

Russian branches of the Slovenian company KRKA produce drugs with the active ingredient amlodipine maleate in dosages of 5 and 10 mg. These are white, round pills with a score line on one side. Indications for use according to the instructions are similar to Amlodipine.

The Indian pharmaceutical industry drug Tenochek contains 2 main ingredients - BMCC and atenolol. These are flat, round pills with a dividing groove on one side. Application: therapy of hypertension and prevention of angina attacks.

The multicomponent drug Triplixam is produced in the Russian Federation and Ireland using the technologies of the French company Servier Laboratories. The basis is amlodipine besilate, the diuretic indapamide and the ACE inhibitor perindopril arginine. Several dosage options. There is no lactose in the composition.

BMKK and ACEI ramipril are a successful combination of active ingredients in the drug Egipres. Available in the form of gelatin capsules from light pink to dark burgundy with a “filling” of white powder and granules. 5 dosage options, no lactose.

For the treatment of essential hypertension (primary hypertension of unknown origin), according to the instructions for use, Indian pills Eucacard are cylindrical in pink and white colors with a mark on one side. 2 dosage options. Contains lactose.

The Hungarian drug Equamer is the first (at the level of evidence-based medicine) poly-tablet with a fixed combination of BMCC, an ACEI (lisinopril) and a statin (rosuvastatin). The pills are available in the form of capsules from light pink to dark purple, in 4 dosage options. Expanded list of indications for use. Contains lactose.

Hungarian Equator tablets are a combined drug (BMCC and ACEI lisinopril) and are available in three dosage options. According to the instructions for use, they are intended for the treatment of essential hypertension. Appearance- whitish round pills with a groove on one side and the marking “A+L” on the opposite.

Exforge tablets complete our fascinating journey through analogues and substitutes of Amlodipine, indicated in the treatment of hypertension. Exforge, according to the instructions for use, contains 2 active ingredients: amlodipine and the angiotensin II antagonist valsartan, does not contain lactose. Available in three dosages in the form of round and oval pills of various shades of yellow, but on one of the flat surfaces of which “NVR” is engraved. Indications for use: hypertension.

What to replace if your legs swell?

During amlodipine therapy, it often turns out that the use of the drug causes swelling in the patient's lower extremities. Then you have to look for something to replace Amlodipine if your legs swell. Below are antihypertensive drugs of other pharmacological groups that can replace the drug, as well as analogues of Amlodipine that do not cause swelling of the lower extremities.

The medicine of the French company Sanofi Avenitis Group - Aprovel - belongs to the pharmaceutical group of angiotensin II enzyme antagonists with the active ingredient irbesartan. It is indicated for the treatment of hypertension and nephropathy in hypertension and diabetes mellitus. Contains lactose.

Lorista

Russian and Slovenian (KRKA companies) Lorista pills belong to combined antihypertensive drugs with 2 active ingredients - the angiotensin II inhibitor losartan and the diuretic hydrochlorothiazide. The auxiliary components contain lactose. Appearance: oval tablets in a gelatin shell, yellowish or greenish-yellow in color. You can replace Amlodipine with these pills, using green or yellow tablets according to the instructions for use if your legs swell from amlodipine. If we compare which is better for lowering blood pressure - Amlodipine or Lorista, then everything is individual, both drugs have both positive and negative reviews.

Lozap, a Slovak and Czech product, which is very popular among hypertensive patients, contains losartan as an active ingredient and belongs to the pharmaceutical group of angiotensin II antagonists. The oblong-convex white tablets do not contain lactose, are available in a dosage of 100 mg, and are divided by a groove in the middle for ease of breaking. When comparing which is better - Lozap or Amlodipine, many patients would probably say - Lozap, but Amlodipine also has its adherents, so it is better to compare based on practical experience.

Lozap Plus tablets from the same company are a combination drug where the active ingredient losartan (50 mg) is combined with the diuretic hydrochlorothiazide (12.5 mg).

These are yellowish, elongated tablets with a dividing groove on both sides; lactose is not present in their composition; the likelihood of developing edema during use is minimal.

The Russian drug directory lists the Turkish-made drug Telzap Plus. This is a combined antihypertensive drug with the angiotensin II antagonist telmisartan and the diuretic hydrochlorothiazide as a base. The instructions for use provide very little information about this medicine.

It is difficult to say which is better - Felodipine or Amlodipine. Both medications are calcium channel blockers, both are indicated for the treatment of hypertension and various types of angina. However, the instructions for use of Felodipine do not indicate such a side effect as edema, which means that it can be used as an analogue of Amlodipine, not swelling legs Although Felodipine is not its direct (structural) substitute.

If the question is: Amlodipine or Lisinopril, which is better, you should carefully study the patient’s medical history for a predisposition to allergic reactions to ACE inhibitors. The angiotensin-converting enzyme inhibitor lisinopril is the basis of this medication and can cause a cough reflex, angioedema and other allergic reactions. At the same time, swelling of the extremities is not included in the list of side effects in the instructions for use of Lisinopril. This means that if the ACEI is well tolerated, lisinopril can be used to replace Amlodipine.

The basis of the French drug Prestarium is the ACE inhibitor perindopril. For this active ingredient, almost all the instructions and warnings set out in the instructions for use for any ACEI are relevant. The list of indications includes hypertension, chronic heart failure, different kinds. What is better - Amlodipine or Prestarium? Neither in terms of the active substance, nor even in the pharmacological group, it is not an analogue of Amlodipine, but if necessary (if the legs swell), Prestarium can replace it in antihypertensive therapy.

Another representative of ACE inhibitors is Enalapril with the active ingredient of the same name.

This active ingredient is present in more than 30 trade names of medications of this pharmacological group, therefore it is very popular among hypertensive patients. But if you compare which is better - Amlodipine or Enalapril, you will have to consider all the possible consequences for the patient from using both. In some, amlodipine causes swelling of the legs, in others, Enalapril leads to angioedema or painful cough. So the drug of choice is a purely individual matter.

Lerkamen

Pharmacological enterprises in Germany and the Russian Federation produce rounded yellow pills Lerkamen. The basis of this drug is lercanidipine, a selective BMCC with a predominant effect on blood vessels. The medication, according to the instructions for use, is indicated for the treatment of essential hypertension. Contains lactose and is accompanied by a significant list of side effects, including peripheral edema. Therefore, it is not easy for a doctor to answer the question of which is better - Amlodipine or Lerkamen. It is easier to suggest that the patient be treated first with one and then with another medication in order to have good grounds for comparison.

Bisoprolol tablets are produced by both Russian and European manufacturers. The drug belongs to the pharmaceutical group of beta-blockers, it is based on bisoprolol hemifumarate, the drug is indicated for the treatment of hypertension and coronary artery disease. To compare Amlodipine or Bisoprolol, which is better, you will have to try the effects of both drugs on yourself, since even the most praised medication may turn out to be unsuitable for a particular organism. Judging by the instructions for use, the lists of side effects for both of them are impressive in their volume.

Analogues with fewer side effects

Is it really impossible to find an analogue of Amlodipine with fewer side effects without conducting experiments on your own health? Yes, it's not that simple. Although you can resort to a little trick and start your search from the most expensive analogues Amlodipine, produced in Israel, Germany, Hungary, Switzerland. Pharmacological enterprises in these countries have long established themselves as producers of high-quality products that are well tolerated by patients. As a rule, the high price of such medications is justified by the minimum side effects, so there is something to think about.

Useful video

From the following video you can learn useful information about hypertension:

Conclusion

The instructions for use of Amlodipine call this drug a calcium channel blocker and recommend its use for the treatment of hypertension and various forms of angina.
The excipients of this medicine contain lactose, which is an obstacle to use in hypertensive patients with intolerance to this disaccharide.
According to the instructions for use, Amlodipine tablets can be taken at any time convenient for the patient, regardless of meals and taking into account the diuretic effect of the drug.
Amlodipine tablets are available in several dosages, which allows you to select the most optimal therapeutic dose for each patient individually.

To increase the therapeutic effect, combination drugs with Amlodipine are prescribed.

You need to take the drug with extreme caution, in compliance with medical recommendations, as complications can occur.

stable type;
vasospastic angina;
heart failure;
ischemic conditions;
bronchial asthma.

Patients are interested in whether they should take Amlodipine before or after meals. In fact, there is no difference, since the process of digesting food does not affect the absorption of the components of the drug.

The drug retains its pharmacological effect for a long time, so you need to know whether Amlodipine should be taken in the morning or in the evening.

Definitely, you need to take the pills at night, only once a day. The drug is prescribed with special care to patients with low body weight and people with renal failure. The initial dosage for these groups should be lower than the standard value, the rate is increased gradually.

For arterial hypertension, the drug must be combined with, and,. For angina pectoris, Amlodipine can be prescribed as an independent medicinal drug, and combine it with other angina medications.

When taking the medicine, body weight may change; this parameter should be controlled. During treatment it is necessary to minimize the norm. Patients are prescribed a salt-free diet. You should also avoid taking it.

Elderly people, patients with low body weight and short stature should undergo therapy under the close supervision of a specialist.

Dosage

You will have to start using the medicine with a minimum dosage. If there are no side effects, the dose should be increased to the maximum threshold. So, the drug is intended for internal use.

Amlodipine tablets

For hypertension, 2.5 mg is prescribed to elderly patients and people with low body weight. Standard dose for healthy person– 5 mg. A one-time dose of tablets is provided. When necessary, the patient switches to a dosage of 10 mg. This can be done 7-10 days after the start of the course.

For angina pectoris, therapy begins with a dosage of 5 mg, with its progressive increase to 10 mg. A one-time dose of the drug is prescribed. The dosage is determined individually, based on age, body weight, general condition body and the severity of the disease.

For people with kidney failure, the drug is prescribed in a standard dosage.

Changing the norm does not affect the severity of the deficiency.

Amlodipine is not excreted during dialysis. Other kidney diseases– indication for reducing the daily volume of the drug. Patients with such ailments are prescribed 2.5 mg. When it is necessary to enhance the body’s diuretic abilities, the norm is increased to 5 mg.

When Amlodipine is combined with beta-blockers, diuretics, ACE inhibitors, no dosage adjustment is necessary.

Overdose

An overdose of the drug manifests itself. Against the background of vasodilation, a decrease may occur.

Patients also experience perfusion of internal organs. Prolonged exposure provokes shock, even death.

To avoid negative consequences, there is no need to delay resuscitation measures. First aid consists of gastric lavage. The patient must take sorbents. After which it is recommended to put the patient in horizontal position, it’s better to raise your legs.

You need to carefully monitor your breathing and heart rate. In this situation, doctors prescribe cleansing procedures, hemodialysis, and the administration of Mezatone and Dopamine.

When the drug is discontinued, the patient's condition may sharply worsen and blood pressure may increase.

Interaction

The hypotensive, antianginal effect of the drug is enhanced when it is combined with the following groups of medications:

antianginal agents, including Preductal, Riboxin;
medicines for kidney failure -, ;
beta blockers, including Celiprolol;
neuroleptic compounds: Olanzapine, Droperidrol;
diuretic group: , Xipamide;
sympathomimetics, including Salbutamol, Isoprenaline.

Nonsteroidal anti-inflammatory drugs, especially Indomethacin, reduce the antianginal effect by inhibiting the synthesis of prostaglandins in the kidneys.

Combined repeated use of Amlodipine (10 mg) with Simvastatin (80 mg) is practiced. At the same time, there is an increase in the effect of the latter by 77% in contrast to monotherapy with it. Therefore, it is necessary to limit the daily dose of this drug to the norm of 20 mg for persons taking Amlodipine.

Side effects

Although the drug is well accepted, there are certain side effects from the medication.

Amlodipine is a medication that can have a negative effect on different parts of the body:

the cardiovascular system. The patient experiences shortness of breath and possibly a decrease in blood pressure and the appearance of hypotension. It also manifests itself more often. Less rarely, symptoms such as migraine and vasculitis, heart failure and rhythm disturbances appear. Tachycardia may develop;
nervous system . Violations also manifest themselves as increased fatigue, drowsiness, nervousness and anxiety. The patient may also be accompanied by conditions such as depression and confusion; apathy and amnesia are much less common;
digestive department. Reactions such as dry mouth and constipation or diarrhea, abdominal pain and flatulence are possible. Much less frequently, but such deviations may occur - anorexia, gastritis, pancreatitis, unreasonably high appetite;
genitourinary. Deviations in this department caused by taking Amlodipine rarely occur. They manifest themselves as frequent urge to urinate, dysuria;
skin. In rare cases, dermatitis and S. Johnson syndrome, urticaria and xeroderma may occur. In this case, the photosensitivity of the skin also increases;
allergic type reactions. Skin rashes and itching, less commonly, angioedema in the form of edema may occur in a patient to the drug;
locomotor system. Long-term use of the medicine or increasing the dosage may cause swelling knee joints and arthrosis, muscle tension and arthralgia;
other violations. These may include visual disturbances and pain in the eye, ringing in the ear and back pain, high sweating and thirst, distortion of the sense of smell and taste buds.

and liver dysfunction - conditions in which Amlodipine is prescribed with extreme caution.

To avoid complications, you need to limit the use of the drug when:

when the level is below 90;
lactose intolerance;
the risk of allergic reactions to specific components;
cardiovascular failure;
pregnancy;
young age;
lactation.

The first month after a heart attack, the use of a hypertensive drug is contraindicated.

How long can you take Amlodipine without interruption?

Patients are wondering whether it is worth taking Amlodipine without interruption. The list of side effects that occur from uncontrolled and continuous use of the drug is very wide.

To avoid harm to the body, do not exceed the dosage of the medicine. It is prohibited to start a new therapeutic course without a break.

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