Tradename
Ergoferon
Dosage form
Oral solution.
Composition (per 100 ml) of oral solution
Active substances:
Antibodies to human interferon gamma, affinity purified 0.12 g*
Antibodies to histamine, affinity purified 0.12 g*
Antibodies to CD4 affinity purified 0.12 g*
* are administered as a mixture of three active aqueous dilutions of the substance, diluted 100^12, 100^30, 100^50 times, respectively.
Excipients: maltitol 6.0 g, glycerol 3.0 g, potassium sorbate 0.165 g, anhydrous citric acid 0.02 g, purified water up to 100 ml.
Description
Colorless or almost colorless transparent liquid.
Pharmacotherapeutic group
Antiviral and immunostimulating agent.
ATX code: L03AX
Pharmacological properties
Pharmacodynamics
The spectrum of pharmacological activity of Ergoferon includes antiviral, immunomodulatory, antihistamine, and anti-inflammatory.
The effectiveness of the use of Ergoferon components in viral infectious diseases has been experimentally and clinically proven: influenza A and B, acute respiratory viral infections (caused by parainfluenza viruses, adenoviruses, respiratory syncytial viruses, coronaviruses), herpes viral infections (labial herpes, ophthalmic herpes, genital herpes, herpes zoster , chicken pox, infectious mononucleosis), acute intestinal infections of viral etiology (caused by caliciviruses, coronaviruses, rotaviruses, enteroviruses), enteroviral and meningococcal meningitis, hemorrhagic fever with renal syndrome, tick-borne encephalitis.
The drug is used in complex therapy bacterial infections(pseudotuberculosis, whooping cough, yersiniosis, pneumonia of various etiologies, including atypical pathogens (M. pneumoniae, C. pneumoniae, Legionella spp.)), used for the prevention of bacterial complications viral infections, prevents the development of superinfections. The use of the drug in the pre- and post-vaccination period increases the effectiveness of vaccination and ensures nonspecific prophylaxis ARVI and influenza at the time of formation of post-vaccination immunity. Ergoferon has preventive effectiveness against ARVI of non-influenza etiology and prevents the development of intercurrent diseases in the post-vaccination period.
The components included in the drug have a single mechanism of action in the form of increasing the functional activity of the CD4 receptor, receptors for interferon gamma (IFN-γ) and histamine, respectively; which is accompanied by a pronounced immunotropic effect.
It has been experimentally proven that
increase the expression of IFN-γ, IFN a/β, as well as interleukins associated with them (IL-2, IL-4, IL-10, etc.), improve the ligand-receptor interaction of IFN, restore cytokine status; normalize the concentration and functional activity of natural antibodies to IFN-γ, which are important factor natural antiviral tolerance of the body; stimulate interferon-dependent biological processes: induction of expression of major histocompatibility complex type I, II antigens and Fc receptors, activation of monocytes, stimulation of the functional activity of NK cells, regulation of immunoglobulin synthesis, activating a mixed Th1 and Th2 immune response.
probably being allosteric modulators of this receptor, they regulate the functional activity of the CD4 receptor, which leads to an increase in the functional activity of CD4 lymphocytes, normalization of the CD4/CDP8 immunoregulatory index, as well as the subpopulation composition of immunocompetent cells (CD3, CD4, CD8, CD16, CD20).
modify histamine-dependent activation of peripheral and central H1 receptors and, thus, reduce the tone of bronchial smooth muscles, reduce capillary permeability, which leads to a reduction in the duration and severity of rhinorrhea, swelling of the nasal mucosa, coughing and sneezing, as well as a decrease in the severity of associated infectious process allergic reactions by suppressing the release of histamine from mast cells and basophils, production of leukotrienes, synthesis of adhesion molecules, reduction of eosinophil chemotaxis and platelet aggregation in reactions to contact with an allergen.
The combined use of the components of a complex drug is accompanied by an increase in the antiviral activity of its components.
Pharmacokinetics
Modern sensibility physical and chemical methods analysis (gas-liquid chromatography, high-performance liquid chromatography, gas chromatography-mass spectrometry) does not allow assessing the content of ultra-low doses of antibodies in biological fluids, organs and tissues, which makes it technically impossible to study the pharmacokinetics of the drug Ergoferon.
Indications for use
Prevention and treatment of influenza A and B.
Prevention and treatment of acute respiratory viral infections caused by parainfluenza virus, adenovirus, respiratory syncytial virus, coronavirus.
Prevention and treatment of herpes virus infections (labial herpes, ophthalmic herpes, genital herpes, chicken pox, herpes zoster, infectious mononucleosis).
Prevention and treatment of acute intestinal infections viral etiology (caused by calicivirus, adenovirus, coronavirus, rotavirus, enteroviruses).
Prevention and treatment of enteroviral and meningococcal meningitis, hemorrhagic fever with renal syndrome, tick-borne encephalitis.
Use in complex therapy of bacterial infections (pseudotuberculosis, whooping cough, yersiniosis, pneumonia of various etiologies, including those caused by atypical pathogens (M. pneumoniae, C. pneumoniae, Legionella spp.)); prevention of bacterial complications of viral infections, prevention of superinfections.
Contraindications
Children up to 3 years old.
Increased individual sensitivity to the components of the drug.
Hereditary fructose intolerance (due to the presence of maltitol).
Carefully:
diabetes.
Use during pregnancy and breastfeeding
The safety of Ergoferon during pregnancy and lactation has not been studied. During pregnancy and during breastfeeding the drug is used only if the expected benefit to the mother outweighs the potential risk to the fetus and child. The benefit/risk ratio is determined by the attending physician.
Directions for use and doses
Inside. For one dose - 1 teaspoon (5 ml) - not during meals. It is advisable to keep the solution in the mouth before swallowing for maximum effect of the drug.
Treatment should begin as early as possible, when the first signs appear acute infection By following diagram: in the first 2 hours the drug is taken every 30 minutes, then during the first 24 hours three more doses are taken at regular intervals. From the second day onwards, take 1 teaspoon 3 times a day until complete recovery.
For the prevention of viral infectious diseases - 1-2 teaspoons per day. The recommended duration of the preventive course is determined individually and can be 1-6 months.
If necessary, the drug can be combined with other antiviral and symptomatic agents.
Side effect
Individual hypersensitivity reactions to the components of the drug are possible. If the specified side effects worsen, or you notice any other side effects not listed in the instructions, tell your doctor.
Overdose
In case of accidental overdose, dyspeptic symptoms (nausea, vomiting, diarrhea) are possible due to the fillers included in the drug (maltitol, glycerol).
Treatment is symptomatic.
Interaction with other drugs
During the clinical studies conducted, no data were obtained on the interaction of the drug Ergoferon with drugs used as concomitant therapy.
special instructions
Sick diabetes mellitus
It should be remembered that each teaspoon (5 ml) of the drug contains 0.3 g of maltitol, which corresponds to 0.02 bread units (XE). Insulin is required for the metabolism of maltitol, although due to slow hydrolysis and absorption in gastrointestinal tract the need for insulin is low. Energy value maltitol 10 kJ or 2.4 kcal/g, which is significantly less than sucrose. The energy value of one teaspoon of the drug is approximately 5.73 kJ (1.37 kcal).
Impact on the ability to drive vehicles and machinery
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The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!
Ergoferon represents homeopathic medicine With anti-inflammatory And immunomodulatory action. The product is effective against various viruses by activating nonspecific immunity. Used for the treatment and prevention of acute respiratory diseases (influenza, parainfluenza, adenovirus, coronavirus infection, colds, etc.), herpetic infections (labial, genital, herpes zoster, chickenpox, ophthalmic herpes, infectious mononucleosis), viral intestinal infections (rotavirus , enterovirus, coronavirus, adenovirus infections, etc.), enterovirus and meningococcal meningitis, tick-borne encephalitis, hemorrhagic fever with renal syndrome. In addition, Ergoferon is used to prevent bacterial complications in various viral infections.Release forms, varieties and composition
Currently, Ergoferon is available in two dosage forms:- Dissolving tablets for oral administration;
- Oral solution.
The fact is that both tablets and Ergoferon solution are approved for use by children from the age of six months. Therefore both data dosage forms The drug can be considered "children's". In practice, they often ask specifically for “children’s” Ergoferon, meaning a low-dose dosage form intended for use exclusively in children. However, both the solution and Ergoferon tablets are available in a single dosage, and they can be given to babies from 6 months, as a result of which, obviously, there is no specialized “children’s” form and dosage of the drug. The only form and dosage of Ergoferon solution and tablets is suitable for both adults and children, and therefore is both an “adult” and a “children’s” version of the drug.
Ergoferon lozenges have a flat-cylindrical shape, are scored and chamfered, and are painted white or almost White color. On the side with the mark there is the inscription "MATERIA MEDICA", and on the other side - "EGROFERON". Tablets are available in packs of 20, 40 and 100 pieces.
Ergoferon oral solution is a clear, colorless or almost colorless liquid. The solution is available in 100 ml bottles.
Both solution and Ergoferon tablets contain the same active substances:
- Antibodies to interferon gamma, affinity purified – 0.12 g per 100 ml of solution or 0.006 g per tablet;
- Antibodies to histamine, affinity purified – 0.12 g per 100 ml of solution or 0.006 g per tablet;
- Affinity purified antibodies to CD4 - 0.12 g per 100 ml of solution or 0.006 g per tablet.
Active substances are introduced into Ergoferon tablets and solution in homeopathic (ultra-small) dosages, therefore the indication of the content of active components (0.12 g per 100 ml of solution and 0.006 g per tablet) is conditional. So, 0.006 g of active substances per tablet means the following. First, the prepared solution of affinity-purified antibodies in different test tubes is diluted with a water-alcohol mixture to homeopathic concentrations of 10012, 10030, 100200 times. Next, dilutions from each test tube are applied to lactose, completely saturating it. And ready-made lactose powders, impregnated with three different dilutions of three types of antibodies, are introduced as active components into tablets. In a solution for oral administration, active substances, diluted to homeopathic concentrations, are introduced in the form of a mixture. That is, three solutions of each antibody diluted to homeopathic concentrations are mixed and then added to the prepared Ergoferon solution.
Ergoferon tablets contain the following substances as auxiliary components:
- Microcrystalline cellulose;
- Lactose monohydrate;
- Magnesium stearate.
- Glycerol;
- Anhydrous citric acid;
- Maltitol;
- Potassium sorbate;
- Purified water (deionized and distilled).
Therapeutic effect
Ergoferon has antiviral, immunomodulatory, anti-inflammatory and antihistamine effects. The antiviral effect is to ensure effective elimination and suppression of the activity of viruses in the body, which leads to the cure of viral infections. The anti-inflammatory effect is to suppress inflammation in various organs and tissues, which ensures the cure of chronic sluggish inflammatory diseases. The antihistamine effect is to suppress the activity of histamine, which causes swelling, redness, dysfunction and pain in the inflamed area. Accordingly, suppression of histamine activity helps to reduce pain, swelling, redness and normalize the functioning of the inflamed organ or tissue. The immunomodulatory effect is to provide a more intense response immune system, aimed at destroying pathogenic microbes that have entered the body. The active components of the drug have a single mechanism of action, which is to intensify the functioning of the CD4 receptor, interferon receptors and histamine receptors located on cells various organs and systems. Due to the intensification of the functioning of these receptors, biologically active substances such as interferon gamma, histamine, as well as immune cells cause a more powerful and pronounced reaction of the immune system in response to the appearance of pathogenic microorganisms in the body - infectious agents. Accordingly, due to this, a more complete and rapid destruction of pathogenic microorganisms (especially viruses) and recovery from infectious diseases occurs.
Thus, it has been experimentally shown that Ergoferon causes the following effects on the immune system:
- Antibodies to interferon gamma cause an increase in the production of interferons gamma, alpha and beta, as well as interleukins 2, 4 and 10. In addition, antibodies improve the interaction of various cells with the produced interferon and normalize the ratio of cytokines (interleukins, interferons, etc.). Also, antibodies to gamma interferon increase the number of molecules of the major histocompatibility complex on the surface immune cells, activate monocytes and natural killer cells (NK cells). All these effects activate natural antiviral immunity, due to which the immune system successfully destroys viruses. And due to the destruction of viruses, any viral infections are easier, recovery occurs faster, and the risk of complications is reduced.
- Antibodies to the CD4 receptor increase its activity, which causes an increase in the functional activity of CD4 lymphocytes (lymphocytes belonging to the CD4 cluster), and also normalizes the ratio of various populations of immune system cells (such as CD3, CD4, CD8, CD16, CD20). All these effects increase the efficiency of the immune system, due to which recovery from infectious diseases occurs faster, and the body’s overall resistance to various pathologies increases.
- Antibodies to histamine reduce the activation of histamine receptors in various tissues and organs under the influence of histamine. As a result, the tone and tension of the smooth muscles of the bronchi decreases, and the permeability of capillaries decreases, due to which the duration and severity of rhinorrhea (snot), swelling of the nasal mucosa, coughing and sneezing is reduced. In addition, the severity of allergic reactions accompanying infectious diseases is reduced.
The use of Ergoferon before and after vaccinations increases the effectiveness of vaccination, and also ensures the prevention of ARVI and influenza during periods of development of post-vaccination immunity.
Indications for use
Ergoferon tablets and solution are indicated for use in the same following cases:- Prevention and treatment of influenza A and B;
- Prevention and treatment of acute respiratory viral infections (ARVI) caused by a variety of viruses, such as adenovirus, coronavirus, respiratory syncytial virus, parainfluenza virus;
- Prevention and treatment of infections caused by various types herpes virus (labial and genital herpes, ophthalmic herpes, herpes zoster, chicken pox, infectious mononucleosis);
- Prevention and treatment of acute intestinal infections caused by various viruses, such as calicivirus, adenovirus, coronavirus, rotavirus, enterovirus;
- Prevention and treatment of meningitis caused by enteroviruses or meningococci;
- Prevention and treatment of tick-borne encephalitis and hemorrhagic fever with renal syndrome;
- As part of complex therapy for various bacterial infections, such as pseudotuberculosis, whooping cough, yersiniosis, pneumonia (including those caused by atypical pathogenic microbes Mycoplasma pneumoniae, Chlamydia pneumoniae, Legionella spp.);
- Prevention of bacterial complications in various viral infections;
- Prevention of superinfections ( reinfection infection against the background of incomplete recovery from a previous infectious disease).
Instructions for use
Instructions for use of Ergoferon tablets
Tablets can be given to children from the age of six months. The tablets should not be taken with meals, but preferably half an hour before or after meals. At one time, take one tablet, which should be kept in the mouth under the tongue, dissolving until completely dissolved. You should not swallow the tablet whole without dissolving it.
For small children aged six months to three years, it is recommended to dissolve the tablet in a small amount (teaspoon) of cooled boiled water and give it as a solution.
For any disease in which the use of Ergoferon is indicated, you should start using the drug as early as possible - when the first signs of infection appear, without waiting for the full development of the entire set of clinical symptoms. The drug is used for various diseases according to the same following scheme: in the first two hours, the tablets are dissolved every half hour (5 tablets in total), then for the remaining time of the current day, another 3 tablets are taken at equal intervals. That is, on the first day a total of 8 tablets are taken. Then, from the second day until the end of treatment, take one tablet three times a day at regular intervals. Ergoferon is taken until complete recovery, that is, the duration of the course of therapy is determined individually, depending on the speed of recovery. Allowed continuous therapeutic appointment drug for 8 weeks.
Ergoferon is taken one tablet 1 – 2 times a day at regular intervals. The duration of prophylactic administration is determined individually and ranges from one to six months. This means that for prevention, Ergoferon can be taken without interruption for 1 to 6 months.
Taking Ergoferon for both prevention and treatment can be combined with the use of any other antiviral and symptomatic medications.
Instructions for use of Ergoferon solution
The solution is intended for adults and children over three years of age.The solution should not be taken during meals, but optimally half an hour before or after a meal. At one time, take one teaspoon of solution (which corresponds to 5 ml). The Ergoferon solution should not be swallowed immediately, but it is recommended to first hold it in the mouth for 10 to 30 seconds to ensure maximum expression of the therapeutic effect of the drug. In principle, the solution can be swallowed immediately without holding it in the mouth for 10–30 seconds, but in this case the severity of the therapeutic effect will not be maximum.
When the use of Ergoferon is indicated, the solution is taken according to the same regimen. So, on the first day of administration, in the first two hours you should take a teaspoon (5 ml) of solution every half hour (5 spoons in total), and for the remainder of the current day you should drink Ergoferon three more times, a teaspoon (5 ml) every other day. equal periods of time. That is, on the first day of treatment, a total of 8 teaspoons of Ergoferon solution are taken. From the second day of treatment, the drug is taken one teaspoon (5 ml) three times a day at regular intervals. The solution is taken until the symptoms of the disease disappear completely, but not longer than eight weeks. That is, the duration of the course of using Ergoferon for the treatment of various infections is determined individually based on the speed of recovery, and can range from 1 to 8 weeks.
It should be remembered that starting to take Ergoferon for treatment various diseases should be done as early as possible, from the first signs of infection. In other words, there is no need to wait for the full deployment clinical picture infection, or you can start taking Ergoferon as soon as the first signs of a developing disease appear.
For the prevention of various viral infections Ergoferon solution should be taken one teaspoon (5 ml) 1 – 2 times a day for 1 – 6 months.
If necessary, Ergoferon solution can be used in combination with any other antiviral or symptomatic medications.
How to take Ergoferon for prevention?
For the prevention of any diseases for which the use of Ergoferon is indicated, it is recommended to take the drug one tablet or one teaspoon (5 ml) of solution 1 - 2 times a day for 1 - 6 months, without breaks.Use during pregnancy and breastfeeding
The effect of Ergoferon solution and tablets on the course of pregnancy and the condition of the fetus has not been studied for obvious ethical reasons. Therefore, it is currently not known for sure whether the drug Ergoferon has a negative effect on the fetus and the course of pregnancy. However, theoretically, the drug should not adversely affect the fetus and the course of pregnancy. Taking this into account, the drug in any form (solution and tablets) is not recommended for use during pregnancy and breastfeeding, so as not to encounter any (albeit very unlikely) negative consequences for the fetus. If there is still a need to use Ergoferon by a pregnant or lactating woman, then it should be taken only if the expected benefit to the mother outweighs all the risks to the fetus. The risk/benefit ratio should be determined by the attending physician.
special instructions
Ergoferon solution contains maltitol in the amount of 0.09 bread units (XE) per teaspoon (5 ml). And although the processing of maltitol in the amount of 0.09 XE requires a small amount of insulin (less than for the processing of 0.09 XE of sucrose), nevertheless, this circumstance should be known and taken into account by people suffering from diabetes when taking Ergoferon solution.Impact on the ability to operate machinery
Ergoferon tablets and solution do not affect the ability to control mechanisms, since they do not have any effect on the central nervous system. Therefore, while using Ergoferon in one or another dosage form (tablets, solution), you can engage in any type of activity that requires high speed reactions and concentration.Overdose
In case of an accidental overdose of Ergoferon tablets or solution, symptoms of dyspepsia (nausea, vomiting, diarrhea, etc.) may develop due to the excipients included in the drug. In case of overdose, symptomatic medications should be used to eliminate the manifestations of dyspepsia (for diarrhea - Loperamide, for nausea and vomiting - Cerucal).Interaction with other drugs
Ergoferon tablets and solution do not significantly interact with other drugs. This means that both tablets and Ergoferon solution can be used in combination with any other drugs.Ergoferon for children
General provisions
Ergoferon tablets in Russia are approved for use in children from the age of six months, and in Belarus - only from six years. Ergoferon solution is approved for use in Russia for children from the age of three years, and in Belarus - from the age of six years. More stringent restrictions on the use of the drug for children in the Republic of Belarus are due to the peculiarities of the legislation, which allows the use of any homeopathic medicines for children only from the age of six. Ergoferon is widely used both in Russia and in other countries former USSR for the treatment of various colds, respiratory and intestinal infections in children. However, doctors do not have a consensus on the advisability of widespread use of Ergoferon in children. Thus, a number of doctors believe that this drug should not be frequently used to treat viral infections, since it activates the production of interferons from the outside, as a result of which, in subsequent diseases, the body itself does not begin the synthesis of interferons, waiting for stimulation “from the outside.” And interferons are necessary to destroy viruses and cure infectious diseases. As a result, a viral infection that develops after a previous one, during which interferons were used, takes longer and is more severe.
Instructions for use of Ergoferon for children
Children under three years of age should be given Ergoferon only in tablet form. From the age of three, Ergoferon can be given to children both in the form of tablets and as a solution.For children under three years of age, the tablet should not be given whole, but should first be dissolved in a teaspoon of boiled and cooled water. For children over three years of age, the tablet is given in its entirety. The solution is also given to children over three years of age in whole, undiluted form.
It is optimal to give both the solution and Ergoferon tablets half an hour before or after meals. However, if for some reason this is impossible, then Ergoferon can be given in any form (both tablets and solution) at any time, just not during meals.
The tablet should be kept under the tongue, slowly dissolving until it is completely dissolved. The solution or tablet dissolved in water should also not be swallowed immediately, but must first be held in the mouth for 10 to 30 seconds to ensure maximum therapeutic effectiveness. Before giving a child a tablet, dissolved tablet or solution, it is necessary to explain to him that he needs to hold the liquid in his mouth and dissolve the tablet, and not swallow it whole.
For the treatment of various infections, for which the use of Ergoferon is indicated, tablets and solution are used according to the same scheme. On the first day of treatment, in the first two hours, the child is given one tablet or one teaspoon (5 ml) of solution every half hour. That is, during the first two hours of treatment, the child is given five tablets or five teaspoons of Ergoferon with an interval of half an hour between doses. Further, during the remaining time of the first day of treatment, the drug is given one tablet or one teaspoon of solution three more times at equal intervals. In total, on the first day of therapy, the child is given eight tablets or eight spoons of Ergoferon solution. From the second day, the drug is given one tablet or one teaspoon of solution three times a day at regular intervals. Treatment is continued until complete recovery, but not longer than 8 weeks.
For the prevention of various viral infections Ergoferon is given to children one tablet or one teaspoon of solution 1 - 2 times a day for 1 - 6 months, without breaks.
When taking Ergoferon for both prevention and treatment, you can additionally include any other antiviral or symptomatic drugs in the treatment regimen. medications.
Side effects
As side effects, both solution and Ergoferon tablets can only provoke allergic reactions or intolerance reactions to any component of the drug. If a person experiences an allergic reaction or any other manifestations of intolerance, they should immediately stop taking Ergoferon and consult a doctor.Contraindications for use
Ergoferon tablets are contraindicated for use only in children under six months of age and if a person has individual hypersensitivity or allergic reactions to any component.Ergoferon solution is contraindicated for use if a person has the following diseases or states:
- Age under 3 years;
- Individual increased sensitivity or allergic reactions to any components of the drug;
- Fructose intolerance.
Analogs
In the domestic pharmaceutical market medicine Ergoferon has analogue drugs only therapeutic effect, and has no analogues for the active substance. That is, there are no drugs that contain the same active ingredients as Ergoferon on the pharmaceutical market of the countries of the former USSR. But there are analogues of Ergoferon for therapeutic action. This means that Ergoferon analogues are drugs that contain different active substances, but have similar therapeutic effects. So, the following drugs are analogues of Ergoferon in terms of therapeutic effect:
- Alpizarin tablets;
- Amizon tablets;
- Amiksin tablets;
- Tilaxin tablets;
- Tiloram tablets;
- Tiloron capsules and tablets;
- Triazavirin capsules;
- Engystol absorbable tablets;
- Echinacea tablets, granules, drops, lozenges.
Ergoferon - cheaper analogues
The following analogue drugs are cheaper than Ergoferon:- Alpizarin – 170 – 260 rubles for 20 tablets;
- Anaferon and Anaferon for children – 180 – 230 rubles for 20 tablets;
- Arpeflu – 100 – 180 rubles for 20 tablets;
- Hyporamine – 140 – 180 rubles for 20 tablets;
- Yodantipyrine – 180 – 220 rubles for 20 tablets;
- Oksolin ointment – 40 – 70 rubles per tube;
- Echinacea – 50 – 150 rubles.
Reviews
Approximately 2/3 of the reviews about Ergoferon are positive, which is due to a noticeable effect in the treatment of acute respiratory viral infections. Unfortunately, there are other reviews about Ergoferon treatment viral diseases practically none, they are literally isolated, so it is not possible to obtain any objective picture in this case. Thus, reviews of the use of Ergoferon for respiratory viral infections indicate that the drug accelerates recovery and alleviates the course of the disease if taken strictly according to the recommended regimen. Many indicate that the cold went away literally within 2 - 3 days, and was much milder than usual. While taking Ergoferon, elevated body temperature normalizes already on days 2–3, and catarrhal symptoms (snot, cough) are minimal. The effect of Ergoferon is especially noticeable if you start taking it at the first signs of the disease. In these cases, sometimes the drug helped prevent the development of the disease altogether.
There are relatively few negative reviews about Ergoferon, and they are mainly due to a general mistrust of all antiviral drugs. So, in such reviews it is often indicated that the drug seemed to help with ARVI, but at the same time you don’t feel like drinking this medicine, since this will lead to the fact that the immune system will no longer fight viruses on its own without external coercion. Thus, despite the positive effect obtained from taking the drug, people leave negative feedback about it, because they believe that, in principle, such drugs are harmful, as if dampening the body’s own immune system.
In addition, there are a number negative reviews, due to the ineffectiveness of Ergoferon in a particular case. There is also a small number of negative reviews due to the fact that Ergoferon caused diarrhea as a side effect, although it was effective for the treatment of ARVI.
Ergoferon for children - reviews
Most of the reviews on the use of Ergoferon for children are positive (about 85%). It should be noted that all reviews of the use of Ergoferon relate to the treatment and prevention of various acute respiratory viral infections in children. There are no reviews on the use of the drug for children for other indications. Reviews indicate that the drug accelerates recovery and significantly alleviates the course of respiratory disease in children of all ages. Parents indicate that against the background of the use of Ergoferon elevated temperature subsides quickly, catarrhal symptoms (snot, cough) bother the child little, and general weakness and body aches are practically not felt by the child, as a result of which he remains quite active and not capricious even against the background of ARVI.
In addition, parents separately note the ease of use of Ergoferon and the ability to give it to children starting from the age of six months. The tablets have no taste, and therefore children easily agree to take them, which is very important for parents, as it allows treatment to be carried out without spending additional effort on persuading the child to take the medicine.
Parents also note the harmlessness and higher effectiveness of Ergoferon compared to other antiviral drugs that they used previously, such as Anaferon, Arbidol and Viferon.
Many parents indicate in their reviews that after using Ergoferon for the treatment of ARVI, they continued to give the drug for 1 to 2 months for prevention. This preventative treatment turned out to be very effective, since children attended preschool institutions or schools and did not get sick for a long period of time (at least three weeks).
Some reviews indicate that the drug was ineffective in the treatment of acute respiratory viral infections, but was effective as a prophylactic agent, thanks to which the child went to school calmly or kindergarten, and didn’t get sick.
Negative reviews about the use of Ergoferon for children are few and are due either to the ineffectiveness of the drug in this particular case, or to the fundamentally negative attitude of parents towards antiviral drugs, regardless of the therapeutic effect obtained.
A combined drug with a wide spectrum of antiviral activity Ergoferon - instructions for use will introduce you to the features of taking tablets for Get well soon or prevention. Colds, flu, herpetic infections type I II III and IV, keratitis, rotavirus and adenovirus enteritis - this is not the entire list of diseases against which the drug is used. How does Ergoferon differ from therapeutic analogues?
Release form and composition
The international name of the drug is Ergoferon.
Dosage active component considered conditional due to multiple dilution of antibodies aqueous-alcohol solution. Analysis methods cannot calculate the exact dose of active substances in Ergoferon remaining after these manipulations.
Packaging: the medicinal product is available in cardboard box, containing 1 blister with 20 tablets.
Prices and analogues of Ergoferon
The antiviral agent can be purchased at a pharmacy without a prescription at a price of 280 rubles per package.
In the countries of the post-Soviet space there is no generic Ergoferon, which contained the same active substance. But there is therapeutic analogues this remedy: this is the name given to medications that have similar effects and help with the same symptoms.
List of main analogues:
| Name | a brief description of | approximate cost |
| Anaferon | Homeopathic substitute, available in tablet and drop format. 20 tablets per package or 25 ml drops per jar. | 220-310 rubles. |
| Oscillococcinum | Homeopathy to combat viral infections. Available in the form of granules of 6, 12 or 30 pieces. | 360-1420 rubles. |
| Kagocel | Russian alternative to Ergoferon, synthesizing the so-called “late” interferon. 10 tablets in a cardboard box. | 190-230 rubles. |
| Arbidol | Soviet immunomodulatory analogue, available in the form of tablets, capsules and suspensions. 10-20 tablets, 10 capsules or 25 mg powder per package. | 165-920 rubles. |
| Ingavirin | A combined drug that synthesizes interferon. Available in 7 tablets. | 420-510 rubles. |
| Cycloferon | A combined remedy that increases immunity and IF levels. 10-50 capsules per pack. | 180-210 rubles. |
| Trekrezan | A multifunctional medicine used not only against ARVI. Stimulates the immune system and synthesizes interferons. 10, 20 or 50 pieces per pack. | 250-520 rubles. |
| Remantandin | A drug that blocks viral DNA. 10-20 pieces in a pack of thick cardboard. | 70-230 rubles. |
| Midantan | A drug that suppresses the DNA of the virus and prevents its spread. 100 tablets in a glass jar. | 110-125 rubles. |
| Tamiflu | A drug that inhibits neuraminidase and inhibits the spread of the virus in the body. 10 capsules per pack | 1170-1250 rubles. |
| Echinacea extract | A drug plant origin, can be found on sale in the form of drops, capsules or absorbable tablets. | 70-220 rubles. |
Indications for use
Ergoferon should be taken for diseases of viral etiology.
What Ergoferon helps with:
- Flu types A and B.
- ARVI of non-influenza origin: adenoviruses, coronaviruses, RSV, parainfluenza.
- Herpes virus:
- herpes on the lips;
- genital herpes;
- chicken pox and herpes zoster;
- Infectious mononucleosis;
- herpetic eye disease.
- OCVR caused by entero-, rota-, corona- and caliciviruses.
- Meningitis of viral origin, fever, encephalitis.
Ergoferon is used as an auxiliary drug for the treatment of bacterial diseases. It also prevents complications after ARVI and the occurrence of superinfection, and enhances the effect of vaccines.
pharmachologic effect
Ergoferon is positioned as an antiviral, anti-inflammatory, antihistamine and immunomodulatory agent. It is believed that the drug's antibodies increase the functional activity of the CD4 receptor, interferon gamma and histamine receptors, which strengthens the immune system and helps to cope with the disease more quickly.
The manufacturer claims that the effectiveness of Ergoferon has been confirmed clinically and experimentally. However, modern physical and chemical methods of analysis are not sensitive enough to evaluate extremely small homeopathic doses of antibodies. Therefore, research into the mechanisms of action and effectiveness of Egroferon is impossible.
Ergoferon is taken orally. Lozenges are taken 1 hour before meals and 1 hour after meals so that food does not interfere with the absorption of the drug. The tablet must be kept in the mouth until completely dissolved under the tongue for greater effectiveness.
How to take for adults
Scheme of medication use:
To prevent complications and superinfection, the drug should continue to be used, but according to a different scheme intended for prevention.
If necessary, treatment with Ergoferon is carried out in combination with other antiviral and symptomatic medications.
Directions for use for children
Children under 3 years of age should take the tablet after dissolving it in a little warm water. The optimal amount of water is 15-20 ml.
Otherwise, the regimen for taking the drug does not change: to treat colds, children should take the same amount of the drug as adults.
During pregnancy and lactation
During pregnancy and breastfeeding in the first six months of a child’s life, you should refrain from using Ergoferon. There are studies proving its safety for the fetus and children under 6 months. this moment does not exist.
For prevention
As a prevention of viral diseases, Ergoferon should be used daily, 1 or 2 times a day. The drug is taken strictly at the same time; skipping the medication is unacceptable - this will reduce the effectiveness of the prevention.
If the product is used once a day, it should be used in the morning. If used 2 times a day, take the medicine in the morning and evening.
How to use:
- The tablets should be dissolved 1 hour before meals or 1 hour after meals. Take 1 piece at a time.
Duration prophylactic intake Ergoferon can last from 1 month to six months and is prescribed individually by the attending physician.
Side effects
Side effects include an allergic reaction to the components of the drug. It can manifest itself as follows:
- irritation;
- redness of skin areas;
- rash;
- risk of apnea.
No other side effects of the drug have been detected at this time.
Contraindications
Ergoferon, like any homeopathic remedy, safe drug with few contraindications. It should not be taken in the following cases:
- intolerance to auxiliary components: fructose or lactose;
- age less than six months.
What's better?
Ergoferon or Kagocel?
Kagocel is a Russian antiviral drug synthesized from cotton. It is not homeopathic, but its effectiveness and mechanism of action are also not confirmed by serious scientific research. The manufacturer classifies this drug as an “interferon inducer”, therefore, it and Ergoferon have a similar effect.
The advantage of Ergoferon is the possibility of use in early childhood. Kagocel is approved for use only by children over 6 years of age. In addition, it practically does not cause allergic reactions, unlike Kagocel.
The advantage of Kagocel is domestic production, due to which the drug costs less, and more effective components.
Arbidol or Ergoferon?
Arbidol is included in the WHO list of drugs that have a direct antiviral effect, and this distinguishes it favorably from Ergoferon. Arbidol has a more pronounced effect and helps on late stages colds. However, it should not be used in children under 2 years of age, and there is a possibility allergic reaction for Arbidol components is slightly higher.
Ergoferon or Ingavirin?
Pentanedioic acid imidazolylethanamide, which is the active component of Ingavirin, helps synthesize interferon and cope with the disease even in late stages. The drug is more effective and recognized scientific community. Like Ergoferon, it is approved for use by young children.
Ergoferon – good remedy against viruses, which many patients like. It helps you heal faster and prevents further complications. What to choose: the homeopathic drug Ergoferon or similar drugs based on the principle of action - trust a specialist. Illness is not a reason for experimentation.
Does Ergoferon help against the flu and other diseases, why are some T-lymphocytes like sentinels and others like killers, what are interferons and why, if you overdose on Ergoferon, most likely nothing bad will happen to you, the site found out.
In rainy weather, it is not difficult to catch a cold even in summer, and now pharmacy visitors are beginning to again pay attention to antiviral drugs. One of the top sellers in Russian pharmacies, positioning itself as a means for “the treatment of influenza and acute respiratory viral infections in full,” according to pharmaceutical market analysts DSM Group, is Ergoferon, which is among the top twenty among all drugs, and as an antiviral drug it is second only to Ingavirin and Kagocel.
Unlike the previous heroes of the “What are we being treated with” column, as many as four completed studies, registered in the Ministry of Health registry, are devoted to Ergoferon, but it is often equated to drugs with unproven effectiveness. Let's figure out who is right here.
From what, from what
The instructions for Ergoferon state that the drug works thanks to three components: antibodies to interferon gamma, histamine and CD4. We talked about the fact that histamine is associated with inflammation - the body's reaction to damage or foreign substances - in a note about Suprastin, but we will dwell on the other components in a little more detail.
These beautiful “ribbons,” as if created for rhythmic gymnastics, depict the structural elements of a protein molecule. Interferons are released in the body in response to invading viruses and other infections. These substances were discovered by accident when scientists in the middle of the last century noticed that laboratory mice that became ill due to one virus did not become infected with a second one immediately after that. It turned out that interferons signal the cells around to be on alert, keep their heads down and prepare for a siege. True, since many molecules in our body have more than one function, interfering with the work of the immune system must be done with great caution.
The interferon-gamma in question is one of the most classic “immune” interferons. It is produced by T-helpers - lymphocytes, “sentinels” of our immunity, which notice the intruder and call for help an entire army of other cells to deal with him. To be more precise, these are T-helpers of the first type, which, releasing gamma interferon, call for help from their “brothers” - T-killers, which kill infected fellow members of the body (and also cancer cells) to prevent the infection from spreading.
T-helpers and some other immune cells wear “breastplates of distinction” - CD4 receptors (cluster of differentiation 4). These proteins are partially immersed in the membrane and partially stick out. They help the T cell receptor (TCR) “pick up” what other cells show them during the “inspection” when sentinel T-helpers walk around their possessions, checking whether the inhabitants of the body are hiding “forbidden” things like a virus or some abnormal proteins behind its membrane.
So, the active ingredients of Ergoferon, as has long been established, are associated with immunity. There are treatment methods associated with the administration of interferons. The combination of these words with the word “antibodies” sounds even better, which in the majority of people’s brains also lies on the “immunity” shelf.
The magic of numbers
Antibodies do help the immune system work, but only if they need to neutralize or poison a virus or bacteria. But they are designed to bind to... the molecules our immune system uses to protect itself. That is, their goal is to block the “communication” of immune cells and “plug” their hooks, which are needed to pick up and check what they are shown during the inspection. Will this cause harm?
To understand this, it is worth considering how many active ingredients are contained in the drug. Let's remember the school chemistry course and do the math.
According to the instructions for Ergoferon, the drug contains 0.006 g of each of the three medicinal antibody components. Let us take the approximate atomic mass of the antibody as 150 kilodaltons (this number is obtained if we divide the total mass of all atoms of the antibody by 1/12 the mass of a carbon atom). This quantity is numerically equal molar mass, showing how many grams are contained in one mole of a substance. This unit of measurement shows the ratio of grams to molecules. That is, in one mole of antibodies to CD4 there will be 150,000 grams. Manufacturers took 0.006 g, which means we are dealing with 4 * 10 –8 moles.
6.022 * 10 23 mol –1 - how many atoms, molecules or ions are contained in an amount of substance equal to one mole. This means that in 4*10 –8 mole we find 4*10 –8 6,022 10 23 = 24.088*10 15 molecules active substance. Several orders of magnitude less than in a drop of water, but still quite a lot (water, whatever one may say, has much smaller molecules).
Instructions for Ergoferon on the drug’s website
But what are those asterisks next to each 0.006 in the instructions? We read the footnote written in small print: “Lactose monohydrate is applied to lactose in the form of a mixture of three active aqueous-alcoholic dilutions of the substance, diluted respectively 100 12, 100 30, 100 50 times.”
Ecumenical breedings
So our 24,088 * 10 15 pieces of “affinity purified anti-CD4 antibodies” were diluted 1 * 10 100 times on the way to the tablet. When dividing, the degrees are subtracted, and we get 24.088 * 10 –85. That is, at such a concentration, out of 1*10 85 molecules of what was anointed on the Ergoferon tablet, only 24 would be the active substance. But there is a small problem: visible universe There are only about 10 80 particles. To meet 24 anti-CD4 antibody molecules at such a concentration, one would have to make one hundred thousand observable Universes entirely consisting of the “active component” of Ergoferon.
Unfortunately, even in five tablets, which manufacturers recommend taking in the first two hours after manifestation acute symptoms, you are unlikely to be lucky enough to meet them.
It must be admitted that the other two antibodies - to human interferon gamma and to histamine - are less diluted, but are still present in no less homeopathic concentrations. For example, in the “dense” version (human interferon gamma), one molecule must still enter the observable ergoferon Universe. The main and, perhaps, rather interesting additional question in this entertaining chemical problem is the question of who is breeding whom.
That is why an overdose of the drug, as its website honestly reports, does not threaten anything special. If eaten great amount tablets, you can only experience “dyspeptic symptoms caused by the excipients included in the drug.” To enhance the effect, you can also snack on a cardboard box: cellulose, for example, in tablets is five times more than the active substance would be in hundreds of dilutions.
And the most important filler is lactose monohydrate, a derivative of ordinary “milk sugar”. It will only harm people with lactose intolerance. Ultra-high dilutions, sugar balls... Doesn’t remind you of anything? Usually such drugs are called homeopathy, but the manufacturer did not note this in any way either on the website or in the studies.
Not on the lists
In the terminological framework of evidence-based medicine, homeopathy is a pseudoscientific method of treatment that has nothing to do with evidence-based medicine and has not proven superior to placebo.
However, in order for the Ministry of Health to register a drug as a medicine, it needs to undergo clinical trials (although the requirements for them in Russia are often lower than in most developed countries). In the register of permitted clinical trials There are four completed and three ongoing studies.
In the database medical research There are more articles on PubMed - as many as eight. The first link takes us to the journal Antiviral Research, English-language and with an impact factor approaching 5, which is not bad for medical scientific journal.
Impact factor is an indicator that reflects the frequency of citations of articles in a scientific journal over a certain period (usually two years). For example, for one of the largest medical journals, The Lancet, the impact factor is 44.0, and on average for good magazines it is 4.
During the study, doctors compared the effectiveness of Ergoferon and Anaferon against rhinoviruses in vitro and in mice. The article says that thanks to Ergoferon, the body secretes more interferon-beta, and interferon-gamma, on the contrary, less, but not significantly. Typically, beta interferons are produced in large quantities by fibroblasts, and one type is used in drugs to treat multiple sclerosis, so it is not entirely clear how this, together with a decrease in the concentration of interferon-gamma, should help against the flu. The article does not indicate in what concentration Ergoferon was used (maybe not in homeopathic) and in what it was dissolved, but it does indicate that the manufacturers of the drug financed the study.
I checked the effect of antibodies to CD4 on human leukocytes. But here we are not only talking about the whole person, but also about a substance that is too diluted to be present in Ergoferon tablets.
The next test was carried out on humans. According to the manufacturers, it was randomized, double-blind, controlled, and the drugs were administered automatically via a telephone answering machine.
A double-blind, randomized, placebo-controlled method is a method of clinical drug research in which the subjects are not privy to important details of the study. “Double blind” means that neither the subjects nor the experimenters know who is being treated with what, “randomized” means that the assignment to groups is random, and placebo is used to show that the effect of the drug is not based on self-hypnosis and that This medicine helps better than a tablet without active ingredients. This method prevents subjective distortion of the results. Sometimes the control group is given another drug with proven effectiveness, rather than a placebo, to show that the drug not only treats better than nothing, but is superior to its analogues.
However, it is worth understanding that at least the patients could easily distinguish what they were taking: each received either the already known antiviral drug Oseltamivir (Tamiflu) twice a day, or Ergoferon - according to a more complex regimen. In addition, patients were given antipyretics (non-steroidal anti-inflammatory drugs) and other drugs for basic treatment of influenza. But to assess the quality of treatment, they chose mainly subjective indicators: not the death of viruses, but patients’ reports of well-being. The most objective criterion was a decrease in temperature (but do not forget that both groups used antipyretics). 158 people took part in the study.
All co-authors, except one, either received a grant from Materia Medica Holding (manufacturers of Ergoferon) or work there (and one is even the head of the company), which indicates the possibility of bias in the results. The conclusion is that Ergoferon is in no way inferior to Oseltamivir.
Another study again talks about the effectiveness of Ergoferon compared to Tamiflu, but this time in mice. Here they are again injected with four milliliters, the concentration is again not specified.
And now another small surprise: all these studies were carried out in 2016-2017, while the drug began to be sold in 2011.
Too “sighted” statistics
But there are three studies that hit PubMed earlier: in 2011, 2012 and 2014. All of them were published in the peer-reviewed Russian journal “Antibiotics and Chemotherapy” in Russian. The impact factor of this journal is 0.426 (according to the Russian Science Citation Index), and for obvious reasons there is no international citation.
Describes a study of the effect of Ergoferon on “optimizing the treatment of influenza and acute respiratory viral infections,” conducted in just one medical center on 100 patients. The authors honestly admit that it was open and not blind. This leaves a loophole for doctors to deliberately or accidentally influence the outcome (for example, prescribing Ergoferon to patients who show more hope for a speedy recovery). According to its results, the drug significantly contributes to more quick treatment than when taking a placebo, but the risk of error and bias here is too great (and let’s not forget about the concentration of the active substance in the tablets, which is not very effective).
The second study, which compared the effectiveness of Ergoferon and Tamiflu, included only 52 patients out of eight medical centers. The study was not double-blind, and the drugs themselves, the tablets and dosage regimen of which are different, would be difficult to confuse. The only way to “blind” him was to give one group Tamiflu at the same time as a placebo, which looks and is taken like Ergoferon, and vice versa, but the doctors did not do this.
The third study was multicenter, double-blind, placebo-controlled, and randomized. It tested how Ergoferon helps treat influenza in children. It included 162 participants from 13 medical centers. This work also evaluates recovery by “improvement” (a rather vague criterion), but in this case the placebo and drug regimens are the same, which can be called an advantage of the study. There the criterion of body temperature was also used, and antipyretics were also used. Observations were carried out according to the patient's diary and a doctor's examination, and according to the second indicator, the effectiveness of Ergoferon and placebo was almost equivalent. By the way, the third study was conducted on liquid form Ergoferon, but the article does not indicate in what proportion the drug was diluted.
The low concentration of the active substance, as well as the fact that the substance itself, even if it were included in the tablet, would have to play more for viruses than for immunity (“like is treated with like”), makes Ergoferon a classic homeopathic medicine, although this is not indicated on the packaging.
They argue about homeopathy for a long time, breaking spears, but it should be remembered that official science cannot recognize as a medicine something that the molecule of the active substance, according to the manufacturer, has not even been in. Homeopaths start lawsuits with their opponents (for example, with the magazine “Around the World”), trying to prove that their drugs work, but with carefully collected statistics and correct research methods, sugar balls work no better than a placebo. If the reader has a vivid imagination, he may just as well believe in the healing powers of tea with raspberry jam. Compared to cellulose, of which there is much more in the tablet than the active ingredient, using it during a cold is at least more pleasant, and everyone knows folk remedies and falsification scientific research The Presidium of the Russian Academy of Sciences warns against taking homeopathic remedies for the treatment of influenza, tuberculosis, childhood diarrhea, malaria and other serious diseases.
Few people would think of treating tuberculosis or malaria with homeopathy, but with influenza and diarrhea everything is much less obvious. Moreover, in all three unfinished studies of Ergoferon on the website of the Ministry of Health, this is exactly what they are talking about, and in the instructions these two diagnoses are listed as indications for use.
Children are often diagnosed infectious diseases viral etiology (flu, respiratory infections). They are accompanied by fever, runny nose, sore throat, etc. Then parents try to find an effective but safe medicine for the baby. Doctors recommend using safe homeopathic remedies for this purpose.
Ergoferon is precisely a representative of this group of drugs; it demonstrates anti-inflammatory, immunomodulatory, and antihistamine effects. This drug is effective against many viral agents. After its use, the temperature normalizes, the child’s condition is alleviated, recovery is accelerated, and complications do not appear. In addition, it has few contraindications and rarely causes side effects.
Description of dosage forms
The homeopathic remedy strengthens the immune system, helps the body destroy viruses, and relieves inflammation. Ergoferon for children is produced in the form of tablets and a solution that is taken orally. Dose active substance in dosage forms are the same, and they are suitable for patients of different ages.
Composition of the drug in solution form:
- antibodies to interferon γ;
- immunoglobulins class E;
- antibodies to CD4;
- preservative E202;
- glycerol;
- water;
- food additive E965 and E330.
- antibodies to human interferon y;
- class E immunoglobulins (antibodies that block the release of histamine);
- CD4 receptor antibodies;
- milk sugar;
- magnesium stearate;
The drug stimulates the immune system, thereby increasing the body's resistance against viruses and bacteria. It quickly eliminates runny nose and inflammation, and as a result, the child feels better. Immunoglobulins quickly penetrate blood cells and pass through the BBB (blood-brain barrier).
Immunoglobulins find and destroy pathogenic agents that attack the body. Antibodies to interferon y stimulate the production of protein compounds that help fight viruses. Class E immunoglobulins reduce the number of these cells, and as a result, it stops inflammatory process, swelling on the inner lining of the nose, the amount of mucus decreases, the cough goes away.
Doctors highlight the following properties of Ergoferon:
- Destroys viruses that have entered the body.
- Boosts the immune system.
- Stops the inflammatory process.
- Facilitates the passage of bronchial secretions.
- Eliminates nasal congestion, reduces the volume of mucous secretions.
- Relieves allergic manifestations.
After regular use of the drug, a more pronounced immune response to pathogenic microorganisms is ensured. The components of Ergoferon provoke the production of substances that bind to viruses and bacteria and destroy them.
Prescription of the medication
Ergoferon should be given for diseases caused by pathogenic microorganisms:
- Influenza (type A and B).
- Diseases of the respiratory organs of viral origin (parainfluenza, adenoviral infection, etc.).
- Herpetic lesions of the eyes, lips, genitals, herpes zoster, etc.
- Intestinal diseases provoked by calicivirus, adenovirus, rotavirus, etc.
- Inflammation of the membranes of the spinal cord and brain, which is caused by enteroviruses and meningococci.
- Hemorrhagic fever, which is accompanied by severe kidney damage.
- Tick-borne meningoencephalitis.
Ergoferon should also be taken for diseases of bacterial origin:
- Pneumonia.
- Whooping cough.
- Pseudotuberculosis (intestinal infection that affects the digestive tract).
- A disease caused by Yersinia.
These are the main indications for the use of Ergoferon in children.
In addition, the medicine should be given to children to prevent bacterial complications against the background of viral diseases of the respiratory organs. The medication is used to prevent acute intestinal infections. To increase the effectiveness of vaccinations, it is also recommended to take Ergoferon.
This drug is able to fight even new strains of viruses and is not addictive. It is used for viral chickenpox. The medicine is included in the composition complex treatment intestinal infections in children. The main thing is to follow the rules for taking Ergoferon. Parents are interested in the question of at what age to take the medicine. Patients have been using the pills for six months. If the child has not yet learned to swallow the tablet, then before taking it, it is dissolved in water. The liquid dosage form is used from 3 years of age in its pure form.
Use of Ergoferon
As already mentioned, tablets are given to patients from six months. The pills are taken 30 minutes before or after meals. The tablet is placed under the tongue and dissolved until it dissolves. You shouldn't swallow it whole. If the child does not know how to swallow pills, then they are dissolved in 5 ml of warm water. boiled water. Ergoferon is given to children after the first symptoms of an infectious disease appear.
Dosage regimen:
- In the first 2 hours, the patient dissolves 1 pill at an interval of 30 minutes (5 tablets).
- For the remaining time of the same day, the child should take 3 more pills at the same interval.
- From the second day until the end of therapy, the patient should take 1 pill three times at equal intervals.
The duration of the therapeutic course is determined by the pediatrician for each child separately, it all depends on the speed of recovery. Tablets are allowed to be taken for 2 months. Ergoferon for prevention is taken 1 pill once or twice in 24 hours.
Treatment can last from 7 days to 24 weeks. The method of using the solution is oral. The medicine is taken before or after meals by patients over 3 years of age. Single dosage – 5 ml. For the therapeutic effect to be pronounced, the liquid should be held in the mouth for 15 - 30 seconds and only then swallowed.
Ergoferon for children is taken according to the following scheme:
- The first day - 5 ml of medication over 2 hours with an interval of half an hour.
- Until the end of the first day - 5 ml three times with an equal interval between doses.
- It is recommended to drink the solution until the symptoms disappear, but not longer than 2 months.
Ergoferon will be most effective on initial stage diseases. When a complete clinical picture of the infection appears, the drug should be used only as part of complex therapy. To prevent viral infections, the solution is consumed 5 ml once or twice from 7 days to 24 weeks.
Precautionary measures
According to the instructions for use, the tablets are contraindicated in patients under 6 months of age and those with allergies to the components of the drug.
It is prohibited to use the medicine in the form of a solution in the following cases:
- Patients under 3 years of age.
- Allergy to Ergoferon components.
- Fructose malabsorption.
- Lactose deficiency.
- Impaired glucose absorption.
Both dosage forms contain maltitol (a sweetener), for this reason diabetics take the medicine only under the supervision of a doctor. This restriction applies to pregnant women (up to 13 weeks) and lactating women.
As a rule, the drug is well tolerated by patients, but sometimes it provokes side effects. Then the child develops an allergy. In this case, you should abandon Ergoferon and contact your pediatrician. After stopping the medication negative symptoms disappear on their own. Therefore, after taking the medicine, the patient’s condition should be monitored.
If the rules of use are violated, an overdose is possible, which is manifested by abdominal pain, vomiting, rapid loose stools, flatulence, burning behind the sternum. If these signs appear, you should also stop taking the drug so that the negative effects disappear. To improve the condition, the child is given plenty of fluids.
Ergoferon is allowed to be combined with antibacterial drugs. When treating intestinal infections, this medication is successfully combined with enterosorbents, probiotics, and antidiarrheals. Ergoferon is allowed to be taken while driving a car and other activities related to reaction speed and concentration. This is safe, since the medication does not have a sedative effect.
Cost and analogues
Ergoferon in the form of tablets (20 pieces) costs from 300 to 350 rubles. The composition of this drug is unique, however, if there are contraindications in children, it can be replaced with drugs with a similar effect. Since the price of Ergoferon is quite high, many parents are interested in where to find cheaper analogues.
Inexpensive alternatives:
- Kagocel is intended for patients over 6 years of age; it does not contain immunoglobulins. This drug is not contraindicated during pregnancy. Cost - on average 260 rubles.
- based on umifenovir, it is used for the treatment of influenza, acute respiratory infections, inflammation of the bronchi and lungs. In addition, the medicine is used to prevent these diseases. Tablets and suspensions are intended for children over 3 years of age. The drug costs 260 rubles.
- Anaferon is an almost absolute analogue of Ergoferon, which is cheaper. This medicine is suitable for children older than 1 month. Price – 200 rubles.
- Viferon based on interferon is indicated for diseases of a viral nature, hepatitis B, C, D, genitourinary infections and herpes. Suppositories are intended for patients from the first days of life. For packaging you need to pay 240 rubles.
TO expensive analogues Ergoferon includes Ingavirin based on vitaglutam and Amiksin with tilorone in its composition. The first drug has a similar spectrum of action to Ergoferon and is sold in 60 ml capsules. And the second remedy is prohibited for patients under 7 years of age and pregnant women. Ingavirin costs 470 rubles, and Amiksin costs 740 rubles.
Thus, Ergoferon is a good remedy for the treatment of viral infections and some bacterial diseases. The medicine quickly increases immune defense and blocks the development of pathogenic agents. Your pediatrician's approval should be sought before using it. It is important to follow the rules for taking the solution and tablets, otherwise the likelihood of negative reactions in the child increases. For cupping side effects stop the drug and consult a doctor.
