What produces growth hormone? Hormonal status of the newborn

Before you understand how growth hormone (somatotropic hormone) works and why it is prescribed, you need to determine what it is and analyze the effect on the body. Growth hormone can also be called somatotropin, representing in its structure a protein consisting of the 191st amino acid. It is part of the family of polypeptide hormones along with placental lactogen and prolactin.

In humans, growth hormone is produced by the endocrine gland - the pituitary gland. The anterior lobe is responsible for the secretion of somatotropin. Distinctive feature from other hormones of the pituitary gland is produced in large quantities, continuing with some fluctuations in the direction of decrease throughout life.

During the day, growth hormone is synthesized by pituitary cells in waves. There are several time periods when the concentration of somatotropin increases. Peak values ​​occur approximately two hours after a person falls asleep. Concentration also increases with physical activity received during training.

The following factors naturally stimulate the production of a hormone important for growth:

• drop in glucose levels;
• physical exercise;
• increased concentration of estrogen;
• hyperfunction of the thyroid gland, expressed in the occurrence of hyperthyroidism;
• taking a number of amino acids, for example, arginine, ornithine, etc.;
• hunger.

Allows you to stimulate the production of growth hormone proper nutrition with a predominance of protein foods, which contain amino acids that are catalysts for the production of somatotropin:

• meat – chicken, beef;
• cottage cheese, milk;
• cod;
• eggs;
• porridge – oatmeal, rice;
• legumes, cabbage;
• nuts.

“Fast” carbohydrates contained in confectionery products and sugar suppress the synthesis of somatotropin, so it is recommended to exclude these products from the diet. You can replace them with “slow” carbohydrates - cereals, fruit and vegetable dishes, bread made from wholemeal flour. Fats must be on the menu, but in limited quantities.

The process of producing the hormone necessary for life is suppressed by factors such as excessive concentrations of glucose, as well as lipids, diagnosed in the blood.

Level depending on age

Studying information about growth hormone allows you to understand that its concentration changes throughout life and depends on age. The maximum is observed at the stage intrauterine development(approximately 4–6 months). After birth, in further age periods, several peaks are observed when the amount of somatotropin increases significantly. These are periods of intensive growth (infancy - up to one year and adolescence).

After reaching an age when the body's growth stops, growth hormone synthesis begins to decline and its amount decreases by approximately 15% in each subsequent decade.

If the child has early age had a deficiency of growth hormone caused by genetic defects, then he has a number of pathological changes, expressed in growth retardation and sometimes puberty. If the level of somatotropin is below the normal value in an adult due to a developed pituitary adenoma, this can cause a number of negative manifestations:

• rapid rate of accumulation of fat deposits;
• early atherosclerosis;
• decreased physical activity;
• osteoporosis;
• decreased sexual function.

When analyzing the mechanism of action, it becomes clear that such growth hormone can not only slow down development if it is clearly deficient in the body, but also lead to an uncontrolled increase in size, causing a phenomenon such as gigantism.

If an excess is detected in an adult, then acromegaly occurs - a disease characterized by hypertrophied degeneration of tissues and bones. A disproportionate increase may occur lower jaw, nose, hands or feet. Particular suffering is caused by a tongue that has grown to a size that does not fit in the mouth. All internal organs may also enlarge and joints may thicken.

Action and influence on the body

This hormone acquires priority importance for the development of the human body as a mechanism that regulates protein metabolism, as well as the most important processes directly related to growth.

It also has an impact on the normalization of the functioning of various processes necessary for full life.

Overrecruitment extra pounds in case of observed failures in the mechanism of somatotropin production, characterized by its insufficient amount, it is explained by the fact that this hormone takes part in the process of normal breakdown of fats. For this reason, it has gained popularity among ladies who want to quickly get a beautiful figure. For the fat-burning effect to manifest itself, it is necessary that in addition to somatotropin, other hormones are present in the body - the sex and thyroid glands.

• Skin

The synthesis of collagen, which is responsible for the healthy appearance of the skin, maintaining its elasticity and tone, is also not possible without the participation of growth hormone. Its deficiency becomes a trigger for rapid fading and aging of the skin.

If the pituitary gland, which produces vital growth hormone, provides it to the body in the required quantity, then the muscles for a long time remain elastic and strong.

• Bone

In the process of growing up until reaching a certain adolescence, the rate of bone growth is important - it is regulated by the hormone somatotropin. It must be taken into account that it is able to exert its effect on linear growth and protein synthesis only in the presence of insulin. In adults, growth hormone ensures skeletal strength. This is due to the ability in its presence to synthesize vitamin D 3, which is responsible for bone stability.

• Positive body tone

At normal concentrations in any age period growth hormone begins to act as a catalyst for a good mood, filling the body with energy and promoting good sleep. If a person goes to bed before midnight and feels refreshed in the morning, this becomes the key to maintaining health.

Growth hormone is needed to stimulate protein synthesis, which, along with accelerated fat burning, leads to growth muscle mass. Also, with his participation, it can be normally regulated carbohydrate metabolism, improve the functioning of the pancreas.

Use of stimulants

In medical practice, stimulants are used to treat pathologies caused by growth hormone deficiency. The cause may be a hereditary predisposition, birth trauma or craniocerebral lesions - tumors, injuries. With timely treatment after the administration of drugs, children begin to grow and with systematic treatment, by the time they grow up, they reach normal average growth parameters.

In therapeutic practice, somatotropin is also prescribed for the treatment nervous disorders. There is an improvement in memory and stimulation of cognitive functions, mood improves, and stress resistance is strengthened.

Like other therapies, stimulants can cause side effects:

• swelling;
• joint pain;
• weakening of kidney function;
• headache;
• the appearance of nausea;
• decreased visual acuity;
• increase in pressure.

Growth hormones have come into use in sports practice, due to their promotion of an increase in muscle mass while simultaneously reducing fat reserves in the body. Another positive effect is the ability of somatotropin to strengthen bones and make cartilage and tendons stronger. Athletes note that when using growth hormone, growth occurs faster. recovery period after injuries.

Since somatotropin helps maintain healthy skin, maintain its elasticity and prevents aging, it has gained popularity in cosmetology. With the right combination of physical activity and taking growth hormone medications, you can make your body fit and slender, while your facial skin becomes smoother and wrinkles gradually disappear.

Kinds

Analyzing artificial types of growth hormone, it should be noted that there are two basic types:

• obtained by methods genetic engineering recombinant somatropin, similar in structural formula natural growth hormone containing 191 amino acids;
• synthetic somatrem containing 192 amino acids.

Somatropin is superior in quality to somatrem, which is why it is used, for example, in sports pharmacology. One of the selection criteria is the homogeneity or degree of purity of the drug, which different manufacturers may be in the range of 94 – 98%. The highest limit of this indicator demonstrates that this preparation contains a minimum of ballast substances and is safer for use.

Growth hormone Wachstum

Growth hormones from Wachstum (Germany) are known for their quality. Among their advantages are the use of high-quality raw materials, a high degree of purification, and an affordable price. This name is translated from German as “growth,” reflecting the main purpose of the drug.

Upon purchase, a complete set will be offered:

• active substance– 10 bottles of 10 units of growth hormone;
• bactericidal water – 10 ampoules of 2 ml each;
• insulin disposable syringes u100 – 10 pieces;
• instructions.

Before use, first, 1 ml of bactericidal water is drawn into the syringe. Then the plastic cap is removed from the bottle containing the active substance. The contents of the syringe are introduced smoothly without shaking into the bottle, where all particles should be completely dissolved. After which, having collected the resulting solution in insulin syringe, the fold of skin on the abdomen is compressed with two fingers of the free hand and the syringe needle is inserted at an angle of approximately 45 degrees and all its contents are slowly squeezed out. The dosage is calculated individually. A range of 5–10 units over 24 hours is considered optimal.

Pharmacological properties:

• muscle strengthening and growth;
• reduction of fat layer;
• stimulation of wound healing;
• rejuvenating effect;
• growth (up to 26 years) and strengthening of bones;
• regulation of protein metabolism;
• increasing immunity.

When starting to use Wachstum growth hormone, you must remember that it, like others similar drugs, there are a number of contraindications:

• allergic reaction;
• malignant tumors;
• serious pathological conditions organism - postoperative period, acute respiratory failure.

It is prohibited for women to start taking somatropin during the entire period of pregnancy and while feeding the baby with breast milk.

Caution must be exercised if the following diseases are diagnosed:

• frequent increase in intracranial pressure;
• diabetes;
• insufficient hormone production thyroid gland– hypothyroidism.

When planning to take the drug, you should keep in mind that the combined use of alcohol and growth hormone is unacceptable. Produced naturally somatotropin has the highest concentration when a person sleeps peacefully, and alcohol negatively affects the biological rhythms of sleep, disrupting them and preventing the production of growth hormones in the amount necessary for the body.

Also, during training, there are regulations prohibiting the consumption of alcohol if somatropin is being taken. This drug already has a strong effect on the entire body, which, under the influence of alcohol-containing substances, can lead to serious negative consequences.

Effect on heart function

Since growth hormone is one of the important regulators of stable cholesterol levels, a deficiency of somatotropin can cause the development of vascular atherosclerosis. Also, when the concentration of growth hormone is insufficient, symptoms appear serious illnesses heart - heart attack, stroke, etc.

During the research, it was revealed that with a normal level of growth hormone for age, the load on the wall of the heart is reduced, which makes it possible to improve its functioning. If, according to physiological indications, somatotropin is prescribed in adulthood, an increase in the mass of the left ventricle and stroke volume of the heart is noted. This drug has been shown to stimulate the production of nitric oxide, leading to dilation of arterial vessels.

Bibliography

1. Androgen deficiency in women and the possibilities of its hormonal diagnosis 2011 / Goncharov N.P., Katsiya G.V., Melikhova O.A., Smetnik V.P.
2. Features of the pathogenesis, diagnosis and treatment of erectile dysfunction in patients with hypogonadism 2010 / Gamidov S.I., Tazhetdinov O.Kh., Pavlovichev A.A., Popova A.Yu., Thagapsoeva R.A.
3. Study of circulating endothelial cells in patients with surgical and natural menopause 2013 / Elena Anatolyevna Kolbasova, Natalya Ivanovna Kiseleva, Lyudmila Vladimirovna Tikhonova

Roman is a bodybuilding trainer with over 8 years of experience. He is also a nutritionist, and his clients include many famous athletes. The novel is with the author of the book “Sport and Nothing But..

The name of the hormone is somatropin. Only in adolescence and childhood is it useful for growth. The hormone is very important for people. Throughout human life it affects metabolism, blood sugar levels, muscle development and fat burning. It can also be synthesized artificially.

Where and how is it produced?

Growth hormone is produced by the anterior pituitary gland. The organ located between the cerebral hemispheres is called the Pituitary gland. The most important hormones for humans are synthesized there, affecting nerve endings and, to a lesser extent, other cells of the human body.

Genetic factors influence hormone production. Today, a complete human genetic map has been compiled. The synthesis of growth hormone is influenced by five genes on chromosome seventeen. Initially, there are two isoforms of this enzyme.

During growth and development, a person produces several additional manufactured forms of this substance. To date, more than five isoforms have been identified that have been found in human blood. Each isoform has a specific effect on the nerve endings of various tissues and organs.

The hormone is produced from time to time with a period of three to five hours during the day. Usually an hour or two after falling asleep at night, the brightest surge in its production of the entire day occurs. During night sleep, several more stages occur sequentially; in total, from two to five times, the hormone synthesized in the pituitary gland enters the blood.

It has been proven that its natural production decreases with age. It reaches a maximum in the second half of the child’s intrauterine development, and then gradually decreases. The maximum frequency of production is achieved in early childhood.

IN adolescence, during puberty, the maximum intensity of its production at a time is observed, however, the frequency is significantly lower than in childhood. Its minimum amount is produced in old age. At this time, both the frequency of production periods and the maximum amount of hormone produced at one time are minimal.

Distribution of growth hormone in the human body

To move inside the body, it, like other hormones, uses circulatory system. To achieve the goal, the hormone binds to its transport protein, which is produced by the body.

Subsequently, it moves to receptors various organs, influencing their work depending on the isoform and the action of other hormones in parallel with somatropin. When it hits a nerve ending, somatropin causes an effect on the target protein. This protein is called Janus kinase. The target protein causes activation of glucose transport to target cells, their development and growth.

First type of impact

Growth hormone owes its name to the fact that it acts on bone tissue receptors located in unclosed bone growth zones. This causes strong growth in children and adolescents during puberty, caused by the growth hormone produced in sufficient quantities in the teenage body at this time. Most often this occurs due to an increase in length tubular bones legs, shin bones, arms. Other bones (such as the spine) also grow, but this is less pronounced.

In addition to the growth of exposed bone areas in at a young age, it causes strengthening of bones, ligaments, teeth throughout life. A lack of synthesis of this substance in the human body may be associated with many diseases that affect older people - mainly diseases of the musculoskeletal system.

Second type of impact

This is an increase in muscle growth and fat burning. This type of impact is widely used in sports and bodybuilding. Three types of techniques are used:

• increasing natural hormone synthesis in the body;
• improved absorption of somatropin associated with other hormones;
• taking synthetic substitutes.

Today, somastatin preparations are prohibited doping. The International Olympic Committee recognized this in 1989.

Third type of impact

Increasing the amount of glucose in the blood due to its effect on liver cells. This mechanism is quite complex, and it allows you to track the connection with other human hormones.

Growth hormone is involved in many other types of activity - it acts on the brain, is involved in activating appetite, affects sexual activity, and both the influence of sex hormones on the synthesis of somatotropin and its influence on the synthesis of sex hormones are observed. It even takes part in the learning process - experiments on mice have shown that those individuals who were additionally injected with it learn better and develop conditioned reflexes.

There are conflicting studies regarding the effect on the aging body. Most experiments confirm that old people who were additionally injected with growth hormone felt much better. Their metabolism and general condition improved, mental and physical activity. At the same time, animal experiments indicate that those individuals who received this drug artificially showed a shorter life expectancy than those who were not administered it.

How is growth hormone related to other hormones?

The production of growth hormone is influenced by two main substances. They are called somastatin and somalibertin. The hormone somastatin inhibits the synthesis of somatotropin, and somalibertin causes increased synthesis. These two hormones are produced there, in the pituitary gland. Interaction and joint effects on the body of somatotropin are observed with the following drugs:

• IGF-1;
• Thyroid hormones;
• Estrogen;
• Adrenal hormones;

This substance is the main intermediary in the absorption of sugar by the body. When a person is exposed to growth hormone, there is an increase in blood sugar. Insulin causes it to decrease. At first glance, the two hormones are antagonists. However, this is not quite true.

Sugar in the blood under the influence of the enzyme is absorbed more efficiently during the work of tissue cells and organs awakened by it. This allows the synthesis of certain types of protein. Insulin helps this glucose be absorbed in order to work more efficiently. Therefore, these substances are allies, and the work of the growth hormone is impossible without insulin.

This is due to the fact that children who have type 1 diabetes grow much slower, and diabetic bodybuilders have difficulty building muscle mass if they lack insulin. However, if there is too much somatropin in the blood, the activity of the pancreas can be “broken” and type 1 diabetes mellitus will occur. Somatropin affects the functioning of the pancreas, which produces.

IGF-1

Factors influencing synthesis within the body

Factors that increase the synthesis of somatropin:

• influence of other hormones;
• hypoglycemia;
• good dream
• physical activity;
• exposure to the cold;
• Fresh air;
• consumption of lysine, glutamine, and some other amino acids.

Reduce synthesis:

• influence of other hormones;
• high concentration of somatropin and IFP-1;
• alcohol, drugs, tobacco, some other psychotropic substances;
• hyperglycemia;
• large amount in blood plasma fatty acids.

Use of growth hormone in medicine

Used in medicine for diseases nervous system, treatment of growth and development delays in childhood, treatment of diseases of the elderly.

Diseases of the nervous system associated with are effectively treated using synthetic somatropin substitutes.

It is necessary to take into account that the use of the drug in this case will in most cases cause a return to the original state, and a long course of its use can cause type 1 diabetes mellitus.

Diseases associated with pituitary dwarfism - some types of dementia, depressive disorders, behavioral disorders. In psychiatry, this drug is used occasionally, during psychotherapy and the recovery period.

During childhood, many children experience delays in growth and development. This is especially true for those whose mother took large doses of alcohol during pregnancy. The fetus may also be exposed to certain doses of alcohol, which cross the placental barrier and reduce the production of somatotropin. As a result, they initially have low levels of somatropin, and children need to take additional synthetic substitutes in order to catch up with their peers in their development.

In children with diabetes, there are periods when blood sugar is high and insulin is insufficient. As a result, their growth and development are delayed. They are prescribed somatropin drugs, which must work in one direction. This will avoid attacks of hyperglycemia. Provided that insulin and somatropin work together, the body tolerates the effects of the drugs more easily.

For older people, the effectiveness of somatropin has been confirmed in the treatment of diseases of the musculoskeletal system. It increases hardness bone tissue, its mineralization, strengthens ligaments and muscle tissue. For some, it helps burn fat tissue.

Unfortunately, taking drugs of this type is associated with an increase in blood sugar levels, which is unacceptable for most older people, and long-term treatment with them is excluded.

Use of growth hormone in sports

The IOC has banned this drug for use by competitive athletes since 1989. However, there is a group of “amateur” competitions in which the use and doping are not controlled - for example, some types of martial arts, some bodybuilding and powerlifting competitions.

It is quite difficult to control the intake of modern synthetic analogues of somatropin in doping tests, and most laboratories do not have suitable equipment.

In bodybuilding, when people train for their own pleasure and not for performances, these substances are used in two types of training - during the “cutting” process and when building muscle mass. During the drying process, the intake is accompanied by a large amount of T4 thyroid hormone analogues. During periods of muscle building, it is taken together with insulin. When burning fat, doctors recommend injecting drugs locally - into the stomach, since men have the most fat in this area.

Pumping up the body's relief with the help of specialized substances allows you to quickly gain large muscle mass, little subcutaneous fat, however, the stomach has big size. This is due to the large amount of glucose absorbed when building muscle mass. However, this practice is much more effective than the use of drugs such as methyltestosterone. Methyltestosterone can activate the process of obesity, in which a person will have to “dry” the body.

Female bodybuilding also did not ignore somatropin. Its analogues are used in conjunction with estrogen instead of insulin. This practice does not cause a strong increase in the abdomen. Many female bodybuilders prefer this one because other doping drugs are associated with male hormones, cause the appearance of male characteristics, masculinization.

In most cases, it will be more effective for a bodybuilder under the age of 30 not to take somatropin. The fact is that while taking this drug you will have to enhance its effect with the help of other hormones, the side symptoms of which (obesity) will need to be compensated for by additional efforts. A lifeline in this situation will be the use of other synthetic drugs, which also increase the endogenous production of growth hormone.

Although most endocrine glands begin to function in utero, the first serious test for the entire system of biological regulation of the body is the moment of childbirth. Birth stress is an important trigger for numerous processes of adaptation of the body to new conditions of existence. Any disturbances and deviations in the functioning of the regulatory neuroendocrine systems that occur during the birth of a child can have a serious impact on the child’s health throughout the rest of his life.

The first - urgent - reaction of the fetal neuroendocrine system at the time of birth is aimed at activating metabolism and external respiration, which did not function at all in utero. The first breath of a child is the most important criterion for a live birth, but in itself it is a consequence of complex nervous, hormonal and metabolic influences. In umbilical cord blood there is a very high concentration of catecholamines - adrenaline and norepinephrine, hormones of “urgent” adaptation. They not only stimulate energy metabolism and the breakdown of fats and polysaccharides in cells, but also inhibit the formation of mucus in lung tissue, and also stimulate the respiratory center located in the brain stem. In the first hours after birth, the activity of the thyroid gland rapidly increases, the hormones of which also stimulate metabolic processes. All these hormonal releases are carried out under the control of the pituitary gland and hypothalamus. Children born by caesarean section and therefore not exposed to the natural stress of childbirth have significantly lower levels of catecholamines and thyroid hormones in the blood, which negatively affects their lung function during the first 24 hours of life. As a result, their brain suffers from some lack of oxygen, and this may have some effect later.

Hormonal regulation of growth

The hypothalamus secretes two oppositely acting hormones - releasing factor and somatostatin, which are sent to the adenopituitary gland and regulate the production and release of growth hormone. It is still unknown what stimulates the release of growth hormone from the pituitary gland more strongly - an increase in the concentration of releasing factor or a decrease in the content of somatostatin. Growth hormone is not secreted evenly, but sporadically, 3-4 times during the day. Increased secretion of growth hormone occurs under the influence of fasting, heavy muscular work, and also during deep sleep: It’s not without reason, apparently, that folk tradition claims that children grow up at night. With age, the secretion of growth hormone decreases, but nevertheless does not stop throughout life. After all, in an adult, growth processes continue, only they no longer lead to an increase in the mass and number of cells, but ensure the replacement of obsolete, spent cells with new ones.

Growth hormone released by the pituitary gland produces two different effects on the cells of the body. The first - direct - effect is that the breakdown of previously accumulated reserves of carbohydrates and fats intensifies in the cells, their mobilization for the needs of energy and plastic metabolism. The second - indirect - action is carried out with the participation of the liver. In its cells, under the influence of growth hormone, mediator substances are produced - somatomedins, which already affect all cells of the body. Under the influence of somatomedins, bone growth, protein synthesis and cell division are enhanced, i.e. the very processes that are commonly called “growth” take place. At the same time, molecules of fatty acids and carbohydrates, released due to the direct action of growth hormone, take part in the processes of protein synthesis and cell division.

If the production of growth hormone is reduced, the child does not grow and becomes a dwarf. At the same time, he maintains a normal physique. Growth may also stop prematurely due to disturbances in the synthesis of somatomedins (it is believed that this substance, for genetic reasons, is not produced in the liver of pygmies, who have the adult height of a 7-10 year old child). On the contrary, hypersecretion of growth hormone in children (for example, due to the development of a benign pituitary tumor) can lead to gigantism. If hypersecretion begins after the ossification of the cartilaginous areas of the bones has already been completed under the influence of sex hormones, acromegaly- limbs, hands and feet, nose, chin and other extremities of the body, as well as the tongue and digestive organs, lengthen disproportionately. Dysfunction of endocrine regulation in patients with acromegaly often leads to various metabolic diseases, including the development of diabetes mellitus. Timely applied hormone therapy or surgical intervention can avoid the most dangerous development of the disease.

Growth hormone begins to be synthesized in the human pituitary gland at the 12th week of intrauterine life, and after the 30th week its concentration in the fetal blood becomes 40 times higher than in an adult. By the time of birth, the concentration of growth hormone drops by about 10 times, but still remains extremely high. In the period from 2 to 7 years, the content of growth hormone in the blood of children remains at approximately a constant level, which is 2-3 times higher than the level of adults. It is significant that during this same period the most rapid growth processes are completed before the onset of puberty. Then comes a period of significant decrease in hormone levels - and growth is inhibited. A new increase in the level of growth hormone in boys is observed after 13 years, and its maximum is observed at 15 years, i.e. just at the moment of the most intense increase in body size in adolescents. By the age of 20, the level of growth hormone in the blood is established at typical adult levels.

With the onset of puberty, sex hormones that stimulate protein anabolism are actively involved in the regulation of growth processes. It is under the influence of androgens that the somatic transformation of a boy into a man occurs, since under the influence of this hormone the growth of bone and muscle tissue. An increase in the concentration of androgens during puberty causes an abrupt increase in the linear dimensions of the body - a pubertal growth spurt occurs. However, following this, the same increased content of androgens leads to ossification of the growth zones in long bones, as a result of which their further growth stops. In the case of premature puberty, body growth in length may begin excessively early, but it will end early, and as a result the boy will remain “undersized.”

Androgens also stimulate increased growth of the muscles and cartilaginous parts of the larynx, as a result of which boys’ voices “break” and become much lower. The anabolic effect of androgens extends to all skeletal muscles of the body, due to which the muscles in men are much more developed than in women. Female estrogens have a less pronounced anabolic effect than androgens. For this reason, in girls during puberty, the increase in muscles and body length is less, and the pubertal growth spurt is less pronounced than in boys.

Direct participation in proper development child's body takes growth hormone (GH). extremely important for a growing organism. The correct and proportional formation of the body depends on HGH. And an excess or deficiency of such a substance leads to gigantism or, conversely, growth retardation. In the body of an adult, somatotropic hormone is contained in smaller quantities than in a child or teenager, but still has important. If the GH hormone is elevated in adults, this can lead to the development of acromegaly.

General information

Somatotropin, or growth hormone, is a growth hormone that regulates the development processes of the entire organism. This substance is produced in the anterior lobe of the pituitary gland. Synthesis growth hormone controlled by two main regulators: somatotropin-releasing factor (STGF) and somatostatin, which are produced by the hypothalamus. Somatostatin and STHF activate the formation of somatotropin and determine the time and amount of its elimination. HGH - the intensity of the metabolism of lipids, proteins, carbohydrates and somatotropin depends on it; it activates glycogen, DNA, accelerates the mobilization of fats from the depot and the breakdown of fatty acids. STH is a hormone that has lactogenic activity. The biological effect of somatotropic hormone is impossible without the low molecular weight peptide somatomedin C. When GH is administered, “secondary” growth-stimulating factors—somatomedins—increase in the blood. The following somatomedins are distinguished: A 1, A 2, B and C. The latter has an insulin-like effect on fat, muscle and cartilage tissue.

The main functions of somatotropin in the human body

Somatotropic hormone (GH) is synthesized throughout life and has a powerful effect on all systems of our body. Let's look at the most important functions such a substance:

• The cardiovascular system. STH is a hormone that is involved in the regulation of cholesterol levels. A deficiency of this substance can provoke vascular atherosclerosis, heart attack, stroke and other diseases.
• Leather. Growth hormone is an essential component in the production of collagen, which is responsible for the condition of the skin. If the hormone (GH) is reduced, collagen is synthesized in insufficient quantities and, as a result, the aging process of the skin accelerates.
• Weight. At night (during sleep), somatotropin is directly involved in the process of lipid breakdown. Violation of this mechanism causes gradual obesity.
• Bone. Somatotropic hormone in children and adolescents ensures the elongation of bones, and in an adult - their strength. This is due to the fact that somatotropin is involved in the synthesis of vitamin D 3 in the body, which is responsible for the stability and strength of bones. This factor helps to cope with various diseases and severe bruises.
• Muscle. STH (hormone) is responsible for the strength and elasticity of muscle fibers.
• Body tone. Somatotropic hormone has a positive effect on the entire body. Helps maintain energy, good mood, and sound sleep.

Growth hormone is very important for maintaining a slim and beautiful body shape. One of the functions of somatotropic hormone is the transformation of adipose tissue into muscle tissue, this is what athletes and everyone who watches their figure achieve. STH is a hormone that improves joint mobility and flexibility, making muscles more elastic.

In older age normal content in the blood somatotropin prolongs longevity. Initially, somatotropic hormone was used to treat various senile ailments. In the world of sports, this substance was used for some time by athletes to build muscle mass, but growth hormone was soon banned for official application, although today it is actively used by bodybuilders.

STH (hormone): norm and deviations

What are the normal values ​​of growth hormone for humans? IN at different ages the indicators of such a substance as growth hormone (hormone) are different. The norm for women also differs significantly from normal values for men:

• Newborns up to one day - 5-53 mcg/l.
• Newborns up to one week - 5-27 mcg/l.
• Children aged from one month to one year - 2-10 mcg/l.
• Middle-aged men - 0-4 mcg/l.
• Middle-aged women - 0-18 mcg/l.
• Men over 60 years of age - 1-9 mcg/l.
• Women over 60 years of age - 1-16 mcg/l.

Somatotropic hormone deficiency in the body

Particular attention is paid to somatotropin in childhood. GH deficiency in children is a serious disorder that can cause not only growth retardation, but also delayed puberty and general development. physical development, and in certain cases - dwarfism. Various factors can cause such a disorder: pathological pregnancy, heredity, hormonal disorders.

An insufficient level of somatotropin in the body of an adult affects the general state of metabolism. Low value growth hormone accompanies various endocrine diseases, and growth hormone deficiency can provoke treatment with certain medications, including the use of chemotherapy.

And now a few words about what happens if there is an excess of somatotropic hormone in the body.

STH is increased

Excess growth hormone in the body can cause more serious consequences. Height increases significantly not only in adolescents, but also in adults. The height of an adult can exceed two meters.

At the same time, there is a significant increase in the limbs - hands, feet, the shape of the face also undergoes serious changes - the nose becomes larger, the features become coarser. Such changes can be corrected, but in this case it will be necessary long-term treatment under the supervision of a specialist.

How to determine the level of growth hormone in the body?

Scientists have found that the synthesis of somatotropin in the body occurs in waves, or in cycles. Therefore, it is very important to know when to take STH (hormone), i.e. at what time to do an analysis for its content. This kind of research is not carried out in regular clinics. The content of somatotropin in the blood can be determined in a specialized laboratory.

What rules should be followed before conducting an analysis?

A week before the test for growth hormone (growth hormone), it is necessary to refuse x-ray examination, as this may affect the reliability of the data. During the day before blood sampling, you should adhere to a strict diet, excluding any fatty foods. Twelve hours before the test, avoid eating any foods. It is also recommended to stop smoking, and within three hours it should be completely eliminated. One day before the test, any physical or emotional overstrain. Blood sampling is carried out in the morning, at this time the concentration of somatotropic hormone in the blood is maximum.

How to stimulate the synthesis of somatotropin in the body?

Today, the pharmaceutical market offers a large number of different drugs containing growth hormone. The course of treatment with such drugs can last several years. But such medications should only be prescribed by a specialist after careful medical examination and in the presence of objective reasons. Self-medication may not only not improve the situation, but can also cause many health problems. In addition, you can activate the production of growth hormone in the body naturally.

1. The most intense production of growth hormone occurs during deep sleep, which is why you need to sleep at least seven to eight hours.
2. Rational diet. The last meal should be at least three hours before bedtime. If the stomach is full, the pituitary gland will not be able to actively synthesize growth hormone. It is recommended to have dinner with easily digestible foods. For example, you can choose low-fat cottage cheese, lean meat, egg whites, and so on.
3. Healthy menu. The basis of nutrition should be fruits, vegetables, dairy and protein products.
4. Blood. It is very important to monitor the level of glucose in the blood; its increase can cause a decrease in the production of somatotropic hormone.
5. Physical activity. For children excellent option There will be sections for volleyball, football, tennis, and sprinting. However, you should know: the duration of any strength training should not exceed 45-50 minutes.
6. Fasting, emotional stress, stress, smoking. Such factors also reduce the production of growth hormone in the body.

In addition, conditions such as diabetes mellitus, pituitary gland injuries, and increased blood cholesterol levels significantly reduce the synthesis of growth hormone in the body.

Conclusion

In this article we examined in detail such essential element, as a somatotropic hormone. The functioning of all systems and organs and the general well-being of a person depend on how its production occurs in the body.

We hope you find the information useful. Be healthy!

Today I will tell you my knowledge about growth hormone (samotropin) what it is, how it works, what properties it has, which one is better (price/quality, fakes and other issues), how to take it (how to use it) and, in short, a whole bunch of things. questions that are somehow related to the pot..

Growth hormone (samotropin) is a peptide hormone of the anterior pituitary gland, which is widely used not only in bodybuilding, but also among many other ordinary people whose goal is to look good.

It is used:

• with growth retardation (in order to grow in length)
• to heal injuries
• as a rejuvenation
• Hollywood actors inject it in order to look as slender and beautiful as possible...
• in general, the list goes on and on, but that’s not what we’re talking about now.

The most important thing to remember: never buy a drug like growth hormone from your hands!

Because this is 100% fake (fake). Only in a pharmacy or trusted companies.

The main producer of GH is considered (well, at least in this moment) - China.

Medicines of Chinese origin are of average quality and low prices(which is a significant plus). It is best to view and purchase products only on large or trusted websites, companies, or in a pharmacy (which is best, but very expensive).

The following growth hormones are currently licensed (i.e. those that have received certificates):

• Ansomon (China, Anhui Anke Biotechnology Co.,Ltd.)
• Jintropin (China, Gensci Pharmaceutical Co., Ltd.)
• Dynatrope is actively licensed (Iran, Dynamic Development)

These are the drugs that you should pay attention to first.

Of course, if you don’t want to buy a fake (but cheaper).

They have the best price/quality ratio, and yes, they are similar in quality to European GR producers, but at the same time they are 5 times cheaper.

So that you understand the amount we are talking about, in Europe growth hormone costs about 12-20 dollars per 1 unit, i.e. for one injection per day (if the dosage is 10 units) in Europe this will cost 100-200 dollars.

And ours is about 25-30 dollars. Can you imagine the difference?

In general, in China as many as 4 companies produce Growth Hormone:

• Jintropin (Gensci Pharmaceutical Co., Ltd.)
• Ansomone (somatrem)(Anhui Anke Biotechnology Co.,Ltd.)
• Hygetropin (Hygene Biopharm Co.,Ltd.)
• Hypertropin (NeoGenica BioScience Ltd.)

The first two (Jintropin and Ansomon) are licensed in our country, they are of good quality.

This can even be checked, for example, Jintropin has a protective sticker and under it there is a unique number (code). Those. you can go to the official website of the GR manufacturer and enter the code and see whether this packaging was produced by this company or is it a fake. This is, firstly.

Secondly, you can and should pay attention to other factors: (signs that this is high-quality GH):

• The packaging itself should be made of thick, moisture-resistant cardboard
• The bottle must come with the original solvent
• The label must be pasted and evenly (equally) on all bottles from the box
• The lid should be aluminum and, most importantly, even (without any traces of manual packaging, so to speak).

The manufacturer must be indicated (namely the manufacturer, not the seller’s or drug’s website, but the manufacturer’s website).

• If the site is not on the packaging or is there, but you come in and such a site does not exist, then it is a fake.
• If the site exists, then look there for the names of the companies, their contact details, in which factories all this stuff is produced, etc. = if all this is not there, then it is a fake.
• If you have contact information, check with them whether they are currently producing the drug. If the answer is no, it's a fake.

In general, these are the basic rules, signs, features of what you need to pay attention to (you need to know this) otherwise you will purchase a fake.

By the way, the main sign of a fake is the price.

Because the price of natural GH is very expensive, if they sell you cheap GH, then it’s a fake. Focus on the price in GR of approximately 25 euros for 10 units. But there are much more expensive ones (read above, in Europe they are generally tough).

Pharmacological properties of growth hormone

• Has an anabolic effect - causes muscle growth
• Has an anti-catabolic effect - inhibits the breakdown (destruction) of muscle tissue (muscles)
• Burns fat
• Increases bone growth (can increase height in young people until growth plates close, i.e. up to 26 years).
• Strengthens bones
• Accelerates wound healing
• Improves energy use
• Strengthens immunity
• Has a rejuvenating effect
• May stimulate regrowth internal organs humans (who atrophied with age)
• Increases blood sugar levels

Please note that the drug itself causes some pharmacological effects.

However! A significant part of its effects (one might say most of the effects of somatropin) are realized due to the insulin-like growth factor IGF-1 (it was previously called samotomedin C), it is produced under the influence of samotropin in the liver and actually stimulates the growth of internal organs.

Therefore, we can safely say that almost all the effects of taking growth hormone in sports are associated precisely with the action of the insulin-like growth factor IGF-1.

As we see pharmacological properties, which growth hormone has, are very highly effective (the drug is really effective), which is why it is so expensive (this is a serious disadvantage), however, I assure you, no other drug can do what growth hormone (samotropin) does and this also explains why people have spent and will continue to spend money on this drug.

How does growth hormone work?

Gaining muscle mass + burning fat.

Please note these are two different processes.

Those who regularly read my issues understand what I’m talking about: gaining weight = excess kcal (you need to eat a lot), and burning fat = deficit of kcal (you can’t eat too much, on the contrary, you need to limit yourself). And when using a pot, what was previously impossible (what is impossible with natural training) becomes possible.

Increase in quantity muscle cells.

This, my friends, is simply a masterpiece effect. Because your gains after a course of taking growth hormone are preserved (and in theory can even grow after the end of the course).

This is another fact that separates anabolic steroids from a course of GH.

Those. Unlike AS (steroids), which have a rollback phenomenon after the end of the cycle, growth hormone does not have this rollback (and this is great). I will say more, after the end of taking the hormone, growth continues because the size of muscle cells in the body increases and they are transferred to new muscle cells.

Minimum side effects from taking growth hormone as opposed to anabolic steroids, this is due to the fact that the gourd does not have the same mechanism of action as AS, therefore growth hormone does not affect the production of sex hormones, moreover, PCT (PCT) post-cycle therapy is not required.

Moreover, growth hormone itself can heal your body from various damages.

And these are just three miraculous functions of this drug.

We will not describe them all, i.e. We have a bodybuilding section, and that’s more than enough. For those who are interested in almost all the properties, scroll up slightly and read the pharmacological properties.

Side effects

Due to the fact that GH is produced naturally in the human body, side effects are rare.

And they arise only when GH is used in large dosages and for a very long time.

In practice, the following side effects occur:

• Pain and numbness in the limbs
• Liquid accumulation (well, not a side effect, but still)
• Increased blood pressure
• Suppression of thyroid function
• Hyperglycemia (this high level blood sugar can be eliminated with insulin).
• Acromegaly - with correct use does not occur, only in cases of abuse.
• Hypertrophy of the heart and other organs (only in case of long-term use and large dosages).
• Enlarged belly (yes it’s true) no matter what anyone says. But, only those athletes (pros) who use megadoses of GH + insulin + steroids + wild, abundant nutrition = big belly.

In general, there are rarely any side effects from GH.

If you do everything correctly (in moderate doses, do not exceed the duration of use).

In addition, almost all side effects are reversible (if done correctly).

If you abuse it (you may develop type 1 diabetes and you will have to inject yourself, or you will have problems with the thyroid gland and you will have to swallow artificial hormones, again for life).

Therefore, it is important to do everything right.

But at the same time, it has been proven that GR is capable of:

• rejuvenate
• improve skin properties
• improve a person's physical fitness
• reduce bad cholesterol levels
• strengthen bones, ligaments
• and many other positive effects.

Growth hormone: general information (details about the important things)

Growth hormone (samotropin) became a banned drug in 1989. Olympic Committee (IOC), but its use by people has not decreased somewhat, but on the contrary has even increased all over the world (both among ordinary people and athletes).

By the way, growth hormone received this name due to the fact that it caused pronounced accelerated growth in length (mainly due to the growth of long tubular bones of the limbs).

The somatotropic hormone preparation itself is somatotropin synthesized using recombinant technologies, which is identical human hormone growth.

The basic concentration of growth hormone in human blood is 1-5 ng/ml, and during peaks it can increase to 10-20 and even 45 ng/ml (mainly after training or at night during sleep).

Those. I want to say that the natural production of growth hormone has a very strong variation (it’s different for everyone), it depends on genetics. To identify a person who is predisposed to high production of GH, simply look at their hands and feet. For one they will be really massive, but for the other they will not.

What affects the natural secretion of growth hormone?

The hypothalamus primarily influences.

It is he who monitors the amount of samotropin and the need for its additional production for the various needs of our body.

For this he has assistants (two peptide hormone) names of which:

• samotropin (it suppresses the production of GH)
• somatoliberin (on the contrary, it stimulates the production of GH)

Actually, it is these hormones that, only if necessary, enter the pituitary gland and force it to either increase or decrease the amount of growth hormone production by somatotropes.

Hence the question: is it possible to somehow influence this hypothalamus?

In order to force him to change the amount of natural growth hormone produced?

The answer is yes. It is possible, because there are many different pharmacological and physiological factors, which affects its production. What are the factors? - you ask.

Factors that stimulate growth hormone

• Somatoliberin (it is an antagonist of somatostatin, so the less it is, the more growth hormone will be produced)
• Amount of protein (the more the better)
• Hypoglycemia (low glucose levels in the human body)
• Ghrelin (regulates the balance of the peak-decline of growth hormone, it is very important for the production of self-totropin because it disrupts the natural production of growth hormone: it increases the concentration regardless of the level of its own somatostatin. Peptides based on it are: GHRP-6, GHRP-2, Hexarelin and Ipamorelin)
• Large production of androgen secretion
• Peptides (CJC-1295, GHRP-2, GHRP-6, GRF (1-29) and some others.

With the help of these factors, you can increase the natural production of growth hormone by 3-5 times, and with the help of peptides, in general, by 10-15 times.

Factors that suppress growth hormone

• Somatostatin (i.e., on the contrary, the more it is, the smaller the peak of growth hormone)
• Hyperglycemia (also the other way around, when there is a lot of sugar in the blood, the less growth hormone, and the less sugar in the blood, the more of it)
• Lots of fatty foods
• The hormone cortisol and other catabolic hormones
• Estrogens (which increase body fat levels and decrease growth hormone levels in the body).
• Excess growth hormone or insulin-like growth factor IGF-1 in the body (i.e., the more of it in the body, the less natural GH the body produces).

Now let's talk about the factors that stimulate and suppress growth hormone, namely:

• Hypoglycemia (low sugar in a person's blood)
• Hyperglycemia (this is a lot of sugar in the blood)

The fact is that growth hormone causes an increase in human blood sugar levels.

Therefore, growth hormone is an insulin antagonist.

This is why it has such a strong effect on the human pancreas, because growth hormone causes it to produce more insulin than nature intended.

And all because growth hormone and insulin = antagonists.

This explains why the lower your blood sugar, the more growth hormone is produced, and vice versa, the higher your blood sugar, the more insulin is produced. Do you see this connection?

When growth hormone raises your blood sugar, it causes your pancreas to produce more insulin. So that there is a balance, otherwise a breakdown will occur...

Your pancreas cannot cope with producing such a large amount of insulin necessary for this balance and will simply refuse... this is what is called type 1 diabetes (insulin dependent).

What I mean is, when you have natural production of growth hormone (that is, you don’t inject yourself with additional GH), then everything is ok. It does not matter. But when you inject yourself with additional growth hormone (increase it tens of times, and then for many months), it requires a lot of insulin (your pancreas has a hard time, it works around the clock) and if this goes on for too long, something will happen breaking.

The pancreas cannot cope and voila, diabetes may develop.

Therefore, you need to take additional insulin (with long and large doses of growth hormone) in order to help yourself, namely your pancreas (with insulin from the outside).

For example, if you inject yourself with 4 units of GH for 2 weeks, then this is not critical.

But if you inject yourself with 10-20 units of growth hormone per day for 3 months = this is critical (you must inject yourself, take additional insulin injections, usually 5 units of short-acting insulin a couple of times a day before large meals will be enough).

Summary of the above

The above test explains why it is so important to use external insulin in case of long-term and large dosages of growth hormone (i.e. more than 10 units + more than 3 months).

In general, insulin is a dangerous weapon (not for beginners, obviously) because it can cause hypoglycemia and if it is not stopped in time, hypoglycemic coma and death are possible. But now you understand (I hope you understand) that it was impossible to talk about the combination of growth hormone + insulin = because your health depends on it.

Still, for most people (if they decide) to use growth hormone, a dosage of up to 10 units per day will be enough (in this case, insulin and other hormones will not be needed, which will not be discussed today, because these are ligaments for professional athletes, and for amateurs and ordinary inhabitants of our island do not need this).

Use of growth hormone (details about the important ones)

Growth hormone has a short lifespan (action period).

This means that in order to maintain a high concentration, you will have to inject frequently.

You need to use (inject) growth hormone:

• In fractional doses during the first half of the day (it’s better not to do this in the evening, I’ll tell you why a little later)
• Either in the middle of a workout or immediately after it

Those. The lower your blood sugar level, the better your growth hormone will work.

That's why best time taking growth hormone will:

• Breakfast (on an empty stomach) because you woke up (you haven’t eaten for a long time, usually 8-10 hours) and your blood sugar level is low (again, because you didn’t eat anything at night).
• After training (the same thing, sugar is low because the carbohydrates eaten before training were spent on the training itself (they were burned) as energy while you tormented the barbells and dumbbells).

Growth hormone: COURSE

For example, your dosage is 10 units per day.

So we do this:

• 1 injection: 5 units in the morning on an empty stomach, immediately after getting out of bed.
• A couple of hours have passed
• 2nd injection: 5 units during training

If you have a workout in the evening (let’s say at 17.00 or 18.00), then do this:

• 1 injection: 5 units in the morning on an empty stomach, immediately after waking up and getting out of bed.
• 2nd injection: 5 units at lunch (half an hour or 1 hour before meals).

This is the optimal scheme. Without the use of insulin and other hormones. This is a solo course of GH.

If you use insulin together with growth hormone, then remember: give an injection of GH and wait 15-30 minutes and only then give an insulin injection. The rule is simple (we do insulin a little later than growth hormone).

The most popular questions (details about the important ones)

#1. How long before meals should I inject growth hormone?

The question is important. If you are not yet able to answer, it means you haven’t read well.

Food (food) = increased blood sugar, and high sugar in the blood reduces the effectiveness of growth hormone.

The answer is obvious: you need to inject when the blood sugar level is low (0.5 - 1 hour before meals and 2 hours after meals). Only in this case will it be as effective as possible!!!

#2. Where to inject growth hormone (in what places)?

It can be in the stomach, or intramuscularly.

Some people colitis intramuscularly (I think this is more correct) because... this speeds up its action. In this case, injections can be given to the triceps or deltoids using an insulin syringe (do it at an angle of 45-90 degrees).

#3. Can I inject growth hormone before bed?

Depending on what goals you are pursuing, it depends on whether you are drying out or gaining muscle mass.

By weight = not possible, by drying = possible. Because the maximum natural release of growth hormone occurs at night, and GH also works very well when blood sugar levels are low. And since you are not cutting (limiting yourself in calories), this should work well, which cannot be said about the mass (because you eat a lot), but depending on what, if you don’t get too fat at night (as many people do), then in theory that’s all should be ok. Here you need to look at the situation.

#4. Is it possible to inject GH at night?

If you wake up at night and give yourself an injection of growth hormone, then it should work well (because low sugar in the blood), especially as we found out during drying, but the effect will also be good on mass.

#5. How do you know if growth hormone is working?

Visually look at yourself in the mirror.

First, water retention should appear.

If you use large doses, your face may become swollen.

But up to 10 units a day this is not the case, there will be water retention and that’s it.

• working weights will increase
• Joints and ligaments will stop hurting (injuries will go away)
• fat will burn (you will become, well, dry).

All these properties will tell you that your growth hormone is really working.

#6. How to give injections, where and how to store growth hormone?

You need to store it in the refrigerator.

You only need to dilute it when you are going to use it.

And for this you will also need to buy water (special) which is sold in pharmacies for diluting powder solutions. Actually, then you fill the water into the insulin syringe and release it into the bottle with growth hormone powder. And then with light movements you shake (dissolve) this powder in that water.

After which you will need to take and draw the resulting solution into the same insulin syringe and inject yourself subcutaneously (in the stomach) or intramuscularly (deltas, triceps)). If you only used a small part solution and there is still some left, then put the rest in the refrigerator. That's all.

Combining growth hormone + steroids

The main goal of combining drugs is to gain relief and muscle mass at the same time.

As well as additional effects:

• improve skin properties
• increase muscle elasticity
• rejuvenate
• etc. (read the pharmacological properties of GH at the very top).

Combinations: either this or that

• Growth hormone + Testosterone enanthate (at a dose of 250-500 mg per week)
• Growth hormone + Sustanon 250 (same dosages as enanthate)
• Growth hormone + Boldenone (dosage 400 mg per week)

Such courses are incredibly powerful due to the synergistic effect, and moreover, the combination of anabolic steroids + growth hormone = is considered supposedly safe for human health, because the drugs have different mechanisms of action (which allows them to be used in moderate doses) without causing hormonal disorders.

After stopping taking anabolic steroids, PCT (PCT) post-cycle therapy is required.

Somehow like this. By the way, if your goal is muscle definition (the initial goal, priority), then it is recommended to use the following combination: either this or that

• GH + anavar (30-50 mg per day, daily)
• GH + Winstrol (30 mg per day, daily)

These drugs, unlike mass-gaining drugs (testosterone enanthate, sustanon or boldenone), have a lesser ability to stimulate muscle growth, but instead they are better suited for burning excess fat and acquiring relief and muscle density.

Also, do not forget about the basis of all the basics:

• Proper nutrition (diet) for gaining muscle mass and strength

And vice versa (if your goal is drying, losing weight):

I've pretty much covered everything (I hope). I do not claim anything, the information is written for people only for informational purposes, I draw attention to this, the administration bears absolutely no responsibility for the use of any hormones, anabolic steroids, any illegal drugs, etc. and so on. we are simply providing public information and nothing more.

Best regards, administrator.