Home Coated tongue General principles of coordination activities of the central nervous system. Basic principles of coordination activities of the central nervous system

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General principles of coordination activities of the central nervous system. Basic principles of coordination activities of the central nervous system

The main principle of the functioning of the central nervous system is the process of regulation, management of physiological functions, which are aimed at maintaining the constancy of properties and composition internal environment body. The central nervous system ensures optimal relationships between the body and environment, stability, integrity, optimal level of vital activity of the body.

There are two main types of regulation: humoral and nervous.

The humoral control process involves changing the physiological activity of the body under the influence of chemicals that are delivered by body fluids. The source of information transmission is chemicals– utilization zones, metabolic products (carbon dioxide, glucose, fatty acids), informons, endocrine gland hormones, local or tissue hormones.

The nervous process of regulation involves controlling changes in physiological functions along nerve fibers using excitation potential under the influence of information transfer.

Features:

1) is a later product of evolution;

2) provides quick regulation;

3) has an exact target of impact;

4) carries out economical way regulation;

5) ensures high reliability of information transmission.

In the body, the nervous and humoral mechanisms work as unified system neurohumoral control. This is a combined form, where two control mechanisms are used simultaneously; they are interconnected and interdependent.

The nervous system is a collection of nerve cells, or neurons.

According to localization they distinguish:

1) central section – brain and spinal cord;

2) peripheral - processes of nerve cells of the brain and spinal cord.

By functional features distinguish:

1) somatic department, regulating motor activity;

2) vegetative, regulating activity internal organs, endocrine glands, blood vessels, trophic innervation of muscles and the central nervous system itself.

Functions of the nervous system:

1) integrative-coordination function. Provides the functions of various organs and physiological systems, coordinates their activities with each other;

2) ensuring close connections between the human body and the environment at the biological and social levels;

3) level regulation metabolic processes in various organs and tissues, as well as in itself;

4) provision mental activity higher departments of the central nervous system.

2. Neuron. Structural features, meaning, types

The structural and functional unit of nervous tissue is the nerve cell - neuron.

A neuron is a specialized cell that is capable of receiving, encoding, transmitting and storing information, establishing contacts with other neurons, and organizing the body’s response to irritation.

Functionally, a neuron is divided into:

1) the receptive part (dendrites and membrane of the soma of the neuron);

2) integrative part (soma with axon hillock);

3) transmitting part (axon hillock with axon).

Perceiving part.

Dendrites– the main receptive field of the neuron. The dendrite membrane is capable of responding to mediators. A neuron has several branching dendrites. This is explained by the fact that a neuron as an information formation must have a large number of inputs. Through specialized contacts, information flows from one neuron to another. These contacts are called "spines".

The neuron soma membrane is 6 nm thick and consists of two layers of lipid molecules. The hydrophilic ends of these molecules face the water phase: one layer of molecules faces inward, the other outward. The hydrophilic ends are turned towards each other - inside the membrane. The lipid bilayer of the membrane contains proteins that perform several functions:

1) pump proteins - move ions and molecules in the cell against a concentration gradient;

2) proteins embedded in the channels provide selective membrane permeability;

3) receptor proteins recognize the necessary molecules and fix them on the membrane;

4) enzymes facilitate the flow chemical reaction on the surface of the neuron.

In some cases, the same protein can serve as both a receptor, an enzyme, and a pump.

Integrative part.

Axon hillock– the point where the axon exits the neuron.

The neuron soma (neuron body) performs, along with an informational and trophic function, relative to its processes and synapses. The soma ensures the growth of dendrites and axons. The neuron soma is enclosed in a multilayer membrane, which ensures the formation and propagation of electrotonic potential to the axon hillock.

Transmitting part.

Axon- an outgrowth of the cytoplasm, adapted to carry information that is collected by dendrites and processed in the neuron. The axon of a dendritic cell has a constant diameter and is covered with a myelin sheath, which is formed from glia; the axon has branched endings containing mitochondria and secretory formations.

Functions of neurons:

1) generalization of the nerve impulse;

2) receiving, storing and transmitting information;

3) the ability to summarize excitatory and inhibitory signals (integrative function).

Types of neurons:

1) by localization:

a) central (brain and spinal cord);

b) peripheral (cerebral ganglia, cranial nerves);

2) depending on the function:

a) afferent (sensitive), carrying information from receptors to the central nervous system;

b) intercalary (connector), in the elementary case providing communication between afferent and efferent neurons;

c) efferent:

– motor – anterior horns of the spinal cord;

– secretory – lateral horns of the spinal cord;

3) depending on the functions:

a) stimulating;

b) inhibitory;

4) depending on the biochemical characteristics, on the nature of the mediator;

5) depending on the quality of the stimulus that is perceived by the neuron:

a) monomodal;

b) multimodal.

3. Reflex arc, its components, types, functions

The activity of the body is a natural reflex reaction to a stimulus. Reflex– the body’s reaction to irritation of receptors, which is carried out with the participation of the central nervous system. The structural basis of the reflex is the reflex arc.

Reflex arc- a series-connected chain of nerve cells that ensures the implementation of a reaction, a response to irritation.

The reflex arc consists of six components: receptors, afferent (sensitive) path, reflex center, efferent (motor, secretory) path, effector (working organ), feedback.

Reflex arcs can be of two types:

1) simple - monosynaptic reflex arcs (reflex arc of the tendon reflex), consisting of 2 neurons (receptor (afferent) and effector), there is 1 synapse between them;

2) complex – polysynaptic reflex arcs. They consist of 3 neurons (there may be more) - a receptor, one or more intercalary and an effector.

The idea of a reflex arc as an expedient response of the body dictates the need to supplement the reflex arc with another link - a feedback loop. This component establishes a connection between the realized result of the reflex reaction and the nerve center that issues executive commands. With the help of this component, the open reflex arc is transformed into a closed one.

Features of a simple monosynaptic reflex arc:

1) geographically close receptor and effector;

2) reflex arc two-neuron, monosynaptic;

3) nerve fibers of group A? (70-120 m/s);

4) short time reflex;

5) muscles contracting according to the type of single muscle contraction.

Features of a complex monosynaptic reflex arc:

1) territorially separated receptor and effector;

2) three-neuron receptor arch (there may be more neurons);

3) the presence of nerve fibers of groups C and B;

4) muscle contraction according to the tetanus type.

Features of the autonomic reflex:

1) the interneuron is located in the lateral horns;

2) the preganglionic nerve pathway begins from the lateral horns, after the ganglion - the postganglionic;

3) the efferent path of the autonomic nervous arch reflex is interrupted by the autonomic ganglion, in which the efferent neuron lies.

The difference between the sympathetic nervous arch and the parasympathetic: the sympathetic nervous arch has a short preganglionic pathway, since the autonomic ganglion lies closer to the spinal cord, and the postganglionic pathway is long.

In the parasympathetic arc, the opposite is true: the preganglionic pathway is long, since the ganglion lies close to the organ or in the organ itself, and the postganglionic pathway is short.

4. Functional systems of the body

Functional system– temporary functional association nerve centers various organs and systems of the body to achieve the final beneficial result.

The beneficial result is a self-forming factor of the nervous system. The result of an action is a vital adaptive indicator that is necessary for the normal functioning of the body.

There are several groups of final useful results:

1) metabolic – a consequence of metabolic processes at the molecular level that create substances and end products necessary for life;

2) homeostatic – constancy of indicators of the state and composition of the body’s media;

3) behavioral – result biological need(sexual, food, drinking);

4) social – satisfaction of social and spiritual needs.

The functional system includes various organs and systems, each of which takes an active part in achieving a useful result.

The functional system, according to P.K. Anokhin, includes five main components:

1) a useful adaptive result - that for which a functional system is created;

2) control apparatus (result acceptor) – a group of nerve cells in which a model of the future result is formed;

3) reverse afferentation (supplies information from the receptor to the central link of the functional system) - secondary afferent nerve impulses that go to the acceptor of the result of the action to evaluate the final result;

4) control apparatus (central link) – functional association of nerve centers with the endocrine system;

5) executive components (reaction apparatus) are organs and physiological systems body (vegetative, endocrine, somatic). Consists of four components:

a) internal organs;

b) endocrine glands;

V) skeletal muscles;

d) behavioral reactions.

Properties of a functional system:

1) dynamism. The functional system may include additional organs and systems, which depends on the complexity of the current situation;

2) the ability to self-regulate. When the controlled value or the final useful result deviates from the optimal value, a series of reactions of a spontaneous complex occur, which returns the indicators to the optimal level. Self-regulation occurs in the presence of feedback.

Several functional systems operate simultaneously in the body. They are in continuous interaction, which is subject to certain principles:

1) the principle of the system of genesis. Selective maturation and evolution of functional systems occur (functional systems of blood circulation, respiration, nutrition, mature and develop earlier than others);

2) the principle of multiply connected interaction. There is a generalization of the activities of various functional systems aimed at achieving a multicomponent result (homeostasis parameters);

3) the principle of hierarchy. Functional systems are arranged in a certain row in accordance with their significance (functional system of tissue integrity, functional nutrition system, functional reproduction system, etc.);

4) the principle of sequential dynamic interaction. There is a clear sequence of changing the activities of one functional system to another.

5. Coordination activities of the central nervous system

Coordination activity (CA) of the CNS is the coordinated work of CNS neurons, based on the interaction of neurons with each other.

CD functions:

1) ensures clear performance of certain functions and reflexes;

2) ensures the consistent inclusion of various nerve centers in the work to ensure complex forms of activity;

3) ensures the coordinated work of various nerve centers (during the act of swallowing, the breath is held at the moment of swallowing; when the swallowing center is excited, the breathing center is inhibited).

Basic principles of CNS CD and their neural mechanisms.

1. The principle of irradiation (propagation). When small groups of neurons are excited, the excitation spreads to a significant number of neurons. Irradiation is explained:

1) the presence of branched endings of axons and dendrites, due to branching, impulses spread to a large number of neurons;

2) availability interneurons in the central nervous system, which ensure the transmission of impulses from cell to cell. Irradiation has boundaries, which are provided by the inhibitory neuron.

2. The principle of convergence. When a large number of neurons are excited, the excitation can converge to one group of nerve cells.

3. The principle of reciprocity - coordinated work of nerve centers, especially in opposite reflexes (flexion, extension, etc.).

4. The principle of dominance. Dominant– the dominant focus of excitation in the central nervous system in at the moment. This is the center of persistent, unwavering, non-spreading excitation. He has certain properties: suppresses the activity of other nerve centers, has increased excitability, attracts nerve impulses from other foci, sums up nerve impulses. Foci of dominant are of two types: exogenous origin (caused by factors external environment) and endogenous (caused by internal environmental factors). The dominant underlies the formation of a conditioned reflex.

5. Feedback principle. Feedback is a flow of impulses into the nervous system that informs the central nervous system about how the response is carried out, whether it is sufficient or not. There are two types of feedback:

1) positive feedback, causing an increased response from the nervous system. Underlies the vicious circle that leads to the development of diseases;

2) negative feedback, reducing the activity of CNS neurons and response. Underlies self-regulation.

6. The principle of subordination. In the central nervous system there is a certain subordination of departments to each other, the highest department being the cerebral cortex.

7. The principle of interaction between the processes of excitation and inhibition. The central nervous system coordinates the processes of excitation and inhibition:

both processes are capable of convergence; the process of excitation and, to a lesser extent, inhibition are capable of irradiation. Inhibition and excitation are connected by inductive relationships. The process of excitation induces inhibition, and vice versa. There are two types of induction:

1) consistent. The process of excitation and inhibition alternates in time;

2) mutual. There are two processes at the same time - excitation and inhibition. Mutual induction is carried out through positive and negative mutual induction: if inhibition occurs in a group of neurons, then foci of excitation arise around it (positive mutual induction), and vice versa.

According to I.P. Pavlov’s definition, excitation and inhibition are two sides of the same process. The coordination activity of the central nervous system ensures clear interaction between individual nerve cells and individual groups of nerve cells. There are three levels of integration.

The first level is ensured due to the fact that impulses from different neurons can converge on the body of one neuron, resulting in either summation or a decrease in excitation.

The second level provides interactions between individual groups of cells.

The third level is provided by cells of the cerebral cortex, which contribute to a more advanced level of adaptation of the activity of the central nervous system to the needs of the body.

6. Types of inhibition, interaction of excitation and inhibition processes in the central nervous system. Experience of I. M. Sechenov

Braking– active process, which occurs when stimuli act on tissue, manifests itself in the suppression of other excitation; there is no functional function of the tissue.

Inhibition can develop only in the form of a local response.

There are two types of braking:

1) primary. For its occurrence, the presence of special inhibitory neurons is necessary. Inhibition occurs primarily without prior excitation under the influence of an inhibitory transmitter. There are two types of primary inhibition:

a) presynaptic in the axo-axonal synapse;

b) postsynaptic in the axodendritic synapse.

2) secondary. It does not require special inhibitory structures, occurs as a result of changes in the functional activity of ordinary excitable structures, and is always associated with the process of excitation. Types of secondary braking:

a) transcendental, which occurs when there is a large flow of information entering the cell. The flow of information lies beyond the functionality of the neuron;

b) pessimal, which occurs with a high frequency of irritation;

c) parabiotic, which occurs during strong and long-term irritation;

d) inhibition following excitation, resulting from a decrease functional state neurons after excitation;

e) inhibition according to the principle of negative induction;

e) inhibition of conditioned reflexes.

The processes of excitation and inhibition are closely related to each other, occur simultaneously and are different manifestations of a single process. Foci of excitation and inhibition are mobile, cover larger or smaller areas of neuronal populations and can be more or less pronounced. Excitation is certainly replaced by inhibition, and vice versa, that is, there is an inductive relationship between inhibition and excitation.

Inhibition underlies the coordination of movements and protects central neurons from overexcitation. Inhibition in the central nervous system can occur when nerve impulses of varying strength from several stimuli simultaneously enter the spinal cord. Stronger stimulation inhibits reflexes that should have occurred in response to weaker ones.

In 1862, I.M. Sechenov discovered the phenomenon of central inhibition. He proved in his experience that irritation with a sodium chloride crystal of the frog's visual tuberosities (the cerebral hemispheres have been removed) causes inhibition of spinal cord reflexes. After the stimulus was removed, the reflex activity of the spinal cord was restored. The result of this experiment allowed I.M. Secheny to conclude that in the central nervous system, along with the process of excitation, a process of inhibition develops, which is capable of inhibiting the reflex acts of the body. N. E. Vvedensky suggested that the phenomenon of inhibition is based on the principle of negative induction: a more excitable area in the central nervous system inhibits the activity of less excitable areas.

Modern interpretation of the experiment of I.M. Sechenov (I.M. Sechenov irritated the reticular formation of the brain stem): excitation of the reticular formation increases the activity of inhibitory neurons of the spinal cord - Renshaw cells, which leads to inhibition of the spinal cord motor neurons and inhibits the reflex activity of the spinal cord.

7. Methods for studying the central nervous system

There are two large groups of methods for studying the central nervous system:

1) experimental method, which is carried out on animals;

2) clinical method, which applies to humans.

To the number experimental methods classical physiology includes methods aimed at activating or suppressing the nerve formation being studied. These include:

1) method of transverse section of the central nervous system at various levels;

2) method of extirpation (removal various departments, organ denervation);

3) method of irritation by activation (adequate irritation - irritation with an electrical impulse similar to a nervous one; inadequate irritation - irritation chemical compounds, graded irritation by electric current) or suppression (blocking the transmission of excitation under the influence of cold, chemical agents, direct current);

4) observation (one of the oldest methods of studying the functioning of the central nervous system that has not lost its significance. It can be used independently, and is often used in combination with other methods).

Experimental methods are often combined with each other when conducting experiments.

Clinical method aimed at studying physiological state Human central nervous system. It includes the following methods:

1) observation;

2) method of registration and analysis electrical potentials brain (electro-, pneumo-, magnetoencephalography);

3) radioisotope method (investigates neurohumoral regulatory systems);

4) conditioned reflex method (studies the functions of the cerebral cortex in the mechanism of learning and the development of adaptive behavior);

5) questionnaire method (assesses the integrative functions of the cerebral cortex);

6) modeling method ( mathematical modeling, physical, etc.). A model is an artificially created mechanism that has a certain functional similarity with the mechanism of the human body being studied;

7) cybernetic method (studies control and communication processes in the nervous system). Aimed at studying organization (systemic properties of the nervous system at various levels), management (selection and implementation of influences necessary to ensure the functioning of an organ or system), information activity (the ability to perceive and process information - an impulse in order to adapt the body to environmental changes).

1. Principle dominants was formulated by A. A. Ukhtomsky as the basic principle of the operation of nerve centers. According to this principle, the activity of the nervous system is characterized by the presence in the central nervous system of dominant (dominant) foci of excitation in a given period of time, in the nerve centers, which determine the direction and nature of the body’s functions during this period. The dominant focus of excitation is characterized by the following properties:

Increased excitability;

Persistence of excitation (inertia), because it is difficult to suppress with other excitation;

The ability to summarize subdominant excitations;

The ability to inhibit subdominant foci of excitation in functionally different nerve centers.

2. Principle spatial relief. It manifests itself in the fact that the total response of the body under the simultaneous action of two relatively weak stimuli will be greater than the sum of the responses obtained during their separate action. The reason for the relief is due to the fact that the axon of an afferent neuron in the central nervous system synapses with a group of nerve cells, in which a central (threshold) zone and a peripheral (subthreshold) “border” are distinguished. Neurons located in the central zone receive from each afferent neuron a sufficient number of synaptic endings (for example, 2) (Fig. 13) to form an action potential. A neuron in the subthreshold zone receives from the same neurons a smaller number of endings (1 each), so their afferent impulses will be insufficient to cause the generation of action potentials in the “border” neurons, and only subthreshold excitation occurs. As a result, with separate stimulation of afferent neurons 1 and 2, reflex reactions arise, the total severity of which is determined only by the neurons of the central zone (3). But with simultaneous stimulation of afferent neurons, action potentials are also generated by neurons in the subthreshold zone. Therefore, the severity of such a total reflex response will be greater. This phenomenon is called central relief. It is more often observed when the body is exposed to weak irritants.

Rice. 13. Scheme of the phenomenon of relief (A) and occlusion (B). The circles indicate the central zones (solid line) and the subthreshold “edge” (dashed line) of the neuron population.

3. Principle occlusion. This principle is the opposite of spatial facilitation and is that the two afferent inputs jointly excite a smaller group of motoneurons compared to the effects of activating them separately. The reason for the occlusion is that the afferent inputs, due to convergence, are partly addressed to the same motor neurons, which are inhibited when both inputs are activated simultaneously (Fig. 13). The phenomenon of occlusion manifests itself in cases of strong afferent stimulation.

4. Principle feedback. The processes of self-regulation in the body are similar to technical ones, which involve automatic regulation of the process using feedback. The presence of feedback allows us to correlate the severity of changes in system parameters with its operation as a whole. The connection between the output of a system and its input with a positive gain is called positive feedback, and with a negative coefficient - negative feedback. IN biological systems positive feedback is implemented mainly in pathological situations. Negative feedback improves the stability of the system, i.e. its ability to return to its original state after the influence of disturbing factors ceases.

Feedback can be divided into various signs. For example, according to the speed of action - fast (nervous) and slow (humoral), etc.

There are many examples of feedback effects. For example, in the nervous system this is how the activity of motor neurons is regulated. The essence of the process is that excitation impulses propagating along the axons of motor neurons reach not only the muscles, but also specialized intermediate neurons (Renshaw cells), the excitation of which inhibits the activity of motor neurons. This effect is known as the process of recurrent inhibition.

An example of positive feedback is the process of generating an action potential. Thus, during the formation of the ascending part of the AP, depolarization of the membrane increases its sodium permeability, which, in turn, increasing the sodium current, increases the depolarization of the membrane.

The importance of feedback mechanisms in maintaining homeostasis is great. So, for example, maintaining a constant level blood pressure carried out by changing the impulse activity of the baroreceptors of the vascular reflexogenic zones, which change the tone of the vasomotor sympathetic nerves and thus normalize blood pressure.

5. Principle reciprocity(combination, conjugation, mutual exclusion). It reflects the nature of the relationship between the centers responsible for the implementation of opposite functions (inhalation and exhalation, flexion and extension of the limb, etc.). For example, activation of the proprioceptors of the flexor muscle simultaneously excites the motor neurons of the flexor muscle and inhibits the motor neurons of the extensor muscle through intercalary inhibitory neurons (Fig. 18). Reciprocal inhibition plays important role in automatic coordination of motor acts.

6. Principle common final path. Effector neurons of the central nervous system (primarily motor neurons of the spinal cord), being the final ones in a chain consisting of afferent, intermediate and effector neurons, can be involved in the implementation of various reactions of the body by excitations coming to them from a large number of afferent and intermediate neurons, for which they are the final pathway (path from the central nervous system to the effector). For example, on the motor neurons of the anterior horns of the spinal cord, which innervate the muscles of the limb, fibers of afferent neurons, neurons of the pyramidal tract and extrapyramidal system (cerebellar nuclei, reticular formation and many other structures) end. Therefore, these motor neurons, which provide reflex activity of the limb, are considered as the final path for general implementation on the limb of many nervous influences.

3-1. What principle underlies the activity of the nervous system? Draw a diagram of its implementation.

3-2. List the protective reflexes that occur when the mucous membrane of the eyes, nasal cavity, mouth, pharynx and esophagus is irritated.

3-3. Check the gag reflex according to all classification criteria.

3-4. Why does the reflex time depend on the number of interneurons?

3-5. Is it possible to register the action potential of nerve A if nerve B is stimulated under the experimental conditions shown in the diagram (at point 1)? What if you apply irritation to nerve A at point 2?

3-6. Will a neuron be excited if subthreshold stimuli are simultaneously applied to it along several axons? Why?

3-7. What must be the frequency of irritating stimuli in order for subthreshold stimulation to cause excitation of a neuron? Give your answer in general terms.

3-8. Neuron A is stimulated along two axons approaching it with a frequency of 50 g. At what frequency can neuron A send impulses along the entire axon?

3-9. What happens to a spinal cord motor neuron when a Renshaw cell is excited?

3-10. Check if the table is compiled correctly:

3-11. Let us assume that the excitation of the center shown below is sufficient to release two quanta of the transmitter for each neuron. How will the excitation of the center and the function of the devices regulated by it change if, instead of one axon, axons A and B are simultaneously stimulated? What is this phenomenon called?

3-12. To excite the neurons of this center, two quanta of the transmitter are enough. List which neurons of the nerve center will be excited if stimulation is applied to axons A and B, B and C, A, B and C? What is this phenomenon called?

3-13. What are the main advantages of nervous regulation of functions compared to humoral regulation?

3-14. Prolonged irritation of the somatic nerve causes the muscle to become fatigued. What will happen to the muscle if we now connect the irritation of the sympathetic nerve going to this muscle? What is this phenomenon called?

3-15. The figure shows kymograms of a cat's knee reflex. Irritation of what structures of the midbrain causes the changes in reflexes shown in kymograms 1 and 2?

3-16. Irritation of what structure of the midbrain causes the reaction shown in the given electroencephalogram? What is this reaction called?

Alpha rhythm Beta rhythm

3-17. At what level must the brainstem be transected to produce the changes in muscle tone shown in the figure? What is this phenomenon called?

3-18. How will the tone of the fore and hind limbs change in a bulbar animal when its head is thrown back?

3-19. How will the tone of the muscles of the front and hind limbs of a bulbar animal change when its head is tilted forward?

3-20. Mark alpha, beta, theta and delta waves on the EEG and give their frequency and amplitude characteristics.

3-21. When measuring the excitability of the soma, dendrites and axon hillock of a neuron, the following figures were obtained: rheobase different departments cells turned out to be equal to 100 mv, 30 mv, 10 mv. Tell me, which parts of the cell correspond to each of the parameters?

3-22. A muscle weighing 150 g consumed 20 ml in 5 minutes. oxygen. Approximately how much oxygen per minute does 150 g of nervous tissue consume under these conditions?

3-23. What happens in the nerve center if impulses arrive at its neurons at a frequency at which acetylcholine does not have time to be completely destroyed by cholinesterase and accumulates on the postsynaptic membrane in large quantities?

3-24. Why, when strychnine is administered, do frogs experience convulsions in response to any, even the slightest, irritation?

3-25. How will the contraction of a neuromuscular drug change if cholinesterase or amine oxidase is added to the perfused fluid?

3-26. The dog's cerebellum was removed two months ago. What symptoms of motor dysfunction can you detect in this animal?

3-27. What happens to the alpha rhythm on the EEG in humans when light stimulation is applied to the eyes and why?

3-28. Which of the presented curves correspond to the action potential (AP), excitatory postsynaptic potential (EPSP) and inhibitory postsynaptic potential (IPSP)?

3-29. The patient has a complete rupture of the spinal cord between the thoracic and lumbar regions. Will he have disorders of defecation and urination, and if so, how will they manifest themselves? different terms after an injury?

3-30. A man developed a non-healing ulcer on his lower leg after a gunshot wound to the buttock area. How can one explain its appearance?

3-31. The animal's reticular formation of the brain stem is destroyed. Can the Sechenov inhibition phenomenon appear under these conditions?

3-32. When the cerebral cortex is irritated, the dog makes movements with its front paws. Which area of the brain do you think is being stimulated?

3-33. The animal was injected with a large dose of chlorpromazine, which blocks the ascending activating system of the reticular formation of the brain stem. How does the animal’s behavior change and why?

3-34. It is known that during narcotic sleep during surgery, the anesthetizer constantly monitors the reaction of the patient’s pupils to light. For what purpose does he do this and what could be the reason for the absence of this reaction?

3-35. The patient is left-handed and suffers from motor aphasia. What area of the cerebral cortex is affected?

3-36. The patient is right-handed and does not remember the names of objects, but gives a correct description of their purpose. What area of the brain is affected in this person?

3-37. A muscle fiber typically has one endplate, and each endplate potential exceeds a threshold level. On the central neurons there are hundreds and thousands of synapses, and the EPSPs of individual synapses do not reach the threshold level. What is the physiological meaning of these differences?

3-38. Two students decided to prove in an experiment that skeletal muscle tone is maintained reflexively. Two spinal frogs were hung on a hook. Their lower paws were slightly tucked, indicating the presence of tone. Then the first student cut the anterior roots of the spinal cord, and the second - the posterior ones. Both frogs' legs hung like whips. Which student performed the experiment correctly?

3-39. Why cooling the brain can extend the duration of the period clinical death?

3-40. Why is it that when a person gets tired, the accuracy of his movements is first impaired, and then the strength of contractions?

3-41. When knee reflex in the patient it is weakly expressed; to strengthen it, sometimes the patient is asked to clasp his hands in front of his chest and pull them in different directions. Why does this lead to an increase in the reflex?

3-42. When one axon is stimulated, 3 neurons are excited. When irritating another - 6. When irritating together, 15 neurons are excited. On how many neurons do these axons converge?

3-43. When learning to write, a child “helps” himself with his head and tongue. What is the mechanism of this phenomenon?

3-44. A flexion reflex was induced in the frog. In this case, the flexor centers are excited and the extensor centers are reciprocally inhibited. During the experiment, postsynaptic potentials of motor neurons are recorded. Which response (flexor EPSP or extensor EPSP) is recorded later?

3-45. With presynaptic inhibition, depolarization of the membrane occurs, and with postsynaptic inhibition, hyperpolarization occurs. Why do these opposite reactions produce the same inhibitory effect?

3-46. When a person stands up, the force of gravity begins to act on him. Why don't your legs bend?

3-47. Do the animal retain any reflexes, other than spinal ones, after transection of the spinal cord under the medulla oblongata? Breathing is supported artificially.

3-48. How can descending influences from the central nervous system alter motor activity without affecting spinal cord motor neurons?

3-49. In the animal, two complete transections of the spinal cord were made successively under the medulla oblongata - at the level of the C-2 and C-4 segments. How will the blood pressure change after the first and second transection?

3-50. Two patients had a cerebral hemorrhage - one of them in the cerebral cortex. in another - in the medulla oblongata. Which patient has a more unfavorable prognosis?

3-51. What happens to a cat in a state of decerebrate rigidity after cutting the brain stem below the red nucleus, if the dorsal roots of the spinal cord are also cut?

3-52. When running on a turn in a stadium track, a speed skater is required to have particularly precise footwork. Does it matter in this situation what position the athlete's head is in?

3-53. Motion sickness (sea sickness) occurs due to irritation vestibular apparatus, which affects redistribution muscle tone. What explains the appearance of symptoms of nausea and dizziness during seasickness?

3-54. In an experiment on a dog, the area of the ventromedial nucleus of the hypothalamus was heated to 50°C, then the animal was kept in normal conditions. How has it changed? appearance dogs after a while?

3-55. When the cerebral cortex is turned off, a person loses consciousness. Is such an effect possible with a completely intact cortex and normal blood supply?

3-56. The patient was found to have gastrointestinal disturbances. The doctor at the clinic referred him for treatment not to a therapeutic clinic, but to a neurological clinic. What could have dictated such a decision?

3-57. One of the main criteria for brain death is the absence of electrical activity in it. Is it possible, by analogy, to speak of the death of a skeletal muscle if an electromyogram cannot be recorded from it at rest?

(Problems No. 3-58 – 3-75 from the Collection of problems edited by G.I. Kositsky [1])

3-58. Can unconditioned reflex be carried out with the participation of only one part of the central nervous system? Is the spinal reflex carried out in the whole organism with the participation of only one (“its own”) segment of the spinal cord? Do the reflexes of a spinal animal differ, and, if so, in what way, from the spinal reflexes carried out with the participation of higher located parts of the central nervous system?

3-59. At what level, I or II, should a brain section be made and how should Sechenov’s experiment be performed to prove the presence of intracentral inhibition?

Frog brain diagram

3-60. Indicate in the figure the structures that perceive changes in the state of skeletal muscles and name their afferent and efferent innervation. What are gamma efferent fibers called and what role do they play in proprioception? Using the diagram, characterize physiological role muscle spindle

3-61.What types of inhibition can be carried out in the structures shown in Figures 1 and 2?

Schemes various forms inhibition in the central nervous system

3-62. Name the structures indicated on the diagram by numbers 1, 2, 3. What process occurs in the terminal branches of axon 1 if an impulse arrives at it along path 1? What process will occur under the influence of impulses from neuron 2 in nerve endings 1?

Location of inhibitory synapses on presynaptic axon branches

3-63. Where can the electrical activity shown in the figure be recorded and what is it called? At what nervous process electrical activity of type 1 is recorded and in which case - type 2. Bioelectric reflections of the functional state of synapses.

3-64. What is the name of the state in which the cat shown in Figure 2 is? At which line I, II, III or IV must an incision be made in order for a cat to develop a condition similar to the one shown in the figure? Which nuclei and which part of the central nervous system are separated from the underlying ones with this incision? 1. Scheme of brain transections at various levels. 2. Cat after brain stem transection.

3-65. Which structural feature Is the autonomic nervous system shown in the diagram? What features of organ innervation are associated with this structure of synaptic connections in the ganglion?

3-66. Having examined the presented diagrams of reflex arcs, determine:

1) Is it possible to register an action potential on the 2nd sensory root upon stimulation of the 1st one in experiment A?

2) Is it possible to register an action potential on motor root 2 upon stimulation of motor root 1 in experiment B?

3) About what physiological phenomenon do the facts obtained in these experiments indicate?

3-67. In which case will there be summation, in which case will there be occlusion? What type of summation in the central nervous system is shown in the diagram?

3-68. The diagram of which part of the autonomic nervous system is shown in the figure? What organs and systems of the body are inverted by this part of the autonomic nervous system?

3-69. The diagram of which part of the autonomic nervous system is shown in the figure? Name the segments of the spinal cord in which its centers are located. Which organs and systems of the body are innervated by this department?

3-70. Explain why there is no primary response to the second “stimulus (when the time of application of the first (conditioning) and second (testing) stimulus is very close. Primary responses arising in specific projection zones of the cortex during two successive irritations of sensitive nerve trunks. The “suppression phenomenon” of the second primary is visible The letters a, b, c, d, d, etc. indicate the order of the experiment. The numbers indicate the time in msec between stimulations.

3-71. Why does the reaction of the cerebral cortex in animals upon afferent stimulation and upon stimulation of the reticular formation have the same manifestations on the EEG? What is this reaction called?

Changes in the electroencephalogram during afferent stimulation (A)

and with irritation of the reticular formation (B).

3-72. Consider both figures and explain why, when irritating the nonspecific nuclei of the thalamus, EEG changes are recorded in different parts of the cerebral cortex? What is this reaction of the cerebral cortex called? Figure A schematically shows the electrical response of various zones of the cerebral cortex to stimulation by rhythmic current of the nonspecific nuclei of the thalamus in a cat. In Figure B there is a recording of EEG changes in zones 1, 2, 3. Below is a mark of irritation.

3-73. What reaction to the sound of a metronome is recorded in the EEG of a cat in a calm state? How does the EEG in Figure A differ from the EEG in Figure B? What is the reason for such EEG changes when a cat reacts to the appearance of a mouse?

Electroencephalographic reactions of a cat to the sound of a metronome in various motivational states (A and B).

3-74. When irritating which brain structures can a defensive reaction occur? By irritating which brain structures can a self-stimulation reaction be obtained in animals?

Behavioral reactions of rats upon stimulation of hypothalamic structures

3-75. Which reflex is shown in the figure? Please explain. How will muscle tone change if the dorsal root of the spinal cord is damaged?

(Tasks No. 3-76 – 3-82 from the CD appendix in the Textbook of Physiology edited by K.V. Sudakov [3])

3-76. Stimuli of equal strength evoke two motor somatic reflexes in an experimental animal. The afferent and efferent parts of the reflex arc in the first reflex are much longer than in the reflex arc of the second reflex. However, the reflex reaction time is shorter in the first case. How can a higher reaction rate be explained in the presence of longer afferent and efferent pathways? What type of nerve fibers are they that ensure the conduction of excitation along the afferent and efferent parts of the somatic reflex arc?

3-77. Administration of the drug to an experimental animal leads to the cessation of somatic reflexes. Which parts of the reflex arc should be subjected to electrical stimulation in order to determine whether this drug blocks the conduction of excitation at the synapses of the central nervous system, the neuromuscular synapse, or disrupts the contractile activity of the skeletal muscle itself.

3-78. Alternate stimulation of two excitatory nerve fibers converging on one neuron does not cause its excitation. When only one of the fibers is stimulated at twice the frequency, the neuron is excited. Can excitation of a neuron occur with simultaneous stimulation of the fibers converging to it?

3-79. Nerve fibers A, B and C converge on one neuron. The arrival of excitation along fiber A causes depolarization of the neuron membrane and the occurrence of an action potential (AP). With the simultaneous arrival of excitation along fibers A and B, AP does not occur and hyperpolarization of the neuron membrane is observed. With the simultaneous arrival of excitation along fibers A and C, AP also does not occur, but hyperpolarization of the neuron membrane does not occur. Which fibers are excitatory and which are inhibitory? What mediators are inhibitory in the central nervous system? In which case does inhibition most likely occur via a postsynaptic mechanism, and in which case does it most likely occur via a presynaptic mechanism?

3-80. A person injured in a car accident suffered a rupture of the spinal cord, resulting in paralysis of the lower limbs? At what level did the spinal cord rupture occur?

3-81. Regulation of physiological functions is ensured by nerve centers - sets of central nervous system structures that can be located on different levels brain, and contribute to ensuring vital processes. From this point of view, which lesion, other things being equal, is more unfavorable for the survival of the patient - hemorrhage in the medulla oblongata or the cerebral hemispheres?

3-82. Pharmacological drug reduces the increased excitability of the cerebral cortex. Animal experiments have shown that the drug does not directly affect cortical neurons. What brain structures can be affected by the indicated drug to cause a decrease in the increased excitability of the cerebral cortex?

To carry out complex reactions, integration of the work of individual nerve centers is necessary. Most reflexes are complex reactions occurring sequentially and simultaneously. Reflexes in the normal state of the body are strictly ordered, since there are general mechanisms their coordination. Excitations arising in the central nervous system irradiate through its centers.

Coordination is ensured by selective excitation of some centers and inhibition of others. Coordination is the unification of the reflex activity of the central nervous system into a single whole, which ensures the implementation of all functions of the body. The following basic principles of coordination are distinguished:

1. The principle of irradiation of excitations. Neurons of different centers are interconnected by interneurons, so impulses arriving during strong and prolonged stimulation of receptors can cause excitation not only of the neurons of the center of a given reflex, but also of other neurons. For example, if you irritate one of the hind legs of a spinal frog by gently squeezing it with tweezers, it contracts (defensive reflex); if the irritation is increased, then both hind legs and even the front legs contract. Irradiation of excitation ensures that, under strong and biologically significant stimulation, more motor neurons are included in the response.

2. The principle of a common final path. Impulses arriving in the central nervous system through different afferent fibers can converge (converge) to the same intercalary, or efferent, neurons. Sherrington called this phenomenon the “common final path principle.” The same motor neuron can be excited by impulses coming from different receptors (visual, auditory, tactile), i.e. participate in many reflex reactions (be included in various reflex arcs).

For example, motor neurons that innervate the respiratory muscles, in addition to providing inspiration, are involved in such reflex reactions as sneezing, coughing, etc. On motor neurons, as a rule, impulses from the cerebral cortex and from many subcortical centers converge (through intercalary neurons or due to direct nerve connections).

On the motor neurons of the anterior horns of the spinal cord, which innervate the muscles of the limb, fibers of the pyramidal tract, extrapyramidal tracts, from the cerebellum, reticular formation and other structures end. The motor neuron, which provides various reflex reactions, is considered as their common final path. Which specific reflex act the motor neurons will be involved in depends on the nature of the stimulation and the functional state of the body.

3. The principle of dominance. It was discovered by A.A. Ukhtomsky, who discovered that irritation of the afferent nerve (or cortical center), usually leading to contraction of the muscles of the limbs when the animal’s intestines are full, causes an act of defecation. In this situation, the reflex excitation of the defecation center suppresses and inhibits the motor centers, and the defecation center begins to react to signals that are foreign to it.

A.A. Ukhtomsky believed that at every given moment of life a defining (dominant) focus of excitation arises, subordinating the activity of the entire nervous system and determining the nature of the adaptive reaction. Excitations from various areas of the central nervous system converge to the dominant focus, and the ability of other centers to respond to signals coming to them is inhibited. Thanks to this, conditions are created for the formation of a certain reaction of the body to the stimulus that has the greatest biological significance, i.e. satisfying a vital need.

Under natural conditions of existence, dominant excitation can cover entire systems of reflexes, resulting in food, defensive, sexual and other forms of activity. The dominant excitation center has a number of properties:

1) its neurons are characterized by high excitability, which promotes the convergence of excitations from other centers to them;

2) its neurons are able to summarize incoming excitations;

3) excitement is characterized by persistence and inertia, i.e. the ability to persist even when the stimulus that caused the formation of the dominant has ceased to act.

Despite the relative stability and inertia of excitation in the dominant focus, the activity of the central nervous system in normal conditions existence is very dynamic and changeable. The central nervous system has the ability to rearrange dominant relationships in accordance with the changing needs of the body. The doctrine of dominance has found wide application in psychology, pedagogy, physiology of mental and physical labor, sports.

4. Feedback principle. The processes occurring in the central nervous system cannot be coordinated if there is no feedback, i.e. data on the results of function management. Feedback allows you to correlate the severity of changes in system parameters with its operation. The connection between a system's output and its input with a positive gain is called positive feedback, and with a negative gain is called negative feedback. Positive feedback is mainly characteristic of pathological situations.

Negative feedback ensures the stability of the system (its ability to return to its original state after the influence of disturbing factors ceases). There are fast (nervous) and slow (humoral) feedbacks. Feedback mechanisms ensure the maintenance of all homeostasis constants. For example, saving normal level blood pressure is carried out by changing the impulse activity of baro-receptors of vascular reflexogenic zones, which change the tone of the vagus and vasomotor sympathetic nerves.

5. The principle of reciprocity. It reflects the nature of the relationship between the centers responsible for the implementation of opposite functions (inhalation and exhalation, flexion and extension of the limbs), and lies in the fact that the neurons of one center, when excited, inhibit the neurons of the other and vice versa.

6. The principle of subordination (subordination). The main trend in the evolution of the nervous system is manifested in the concentration of regulation and coordination functions in the higher parts of the central nervous system - cephalization of the functions of the nervous system. There are hierarchical relationships in the central nervous system - highest center regulation is the cerebral cortex, the basal ganglia, the middle, medulla oblongata and spinal cord obey its commands.

7. The principle of compensation of functions. The central nervous system has a huge compensatory ability, i.e. can restore some functions even after the destruction of a significant part of the neurons that form the nerve center (see plasticity of nerve centers). If individual centers are damaged, their functions can transfer to other brain structures, which is carried out when mandatory participation cerebral cortex. In animals in which the cortex was removed after restoration of lost functions, their loss occurred again.

With a local insufficiency of inhibitory mechanisms or with an excessive increase in excitation processes in a particular nerve center, a certain set of neurons begins to autonomously generate pathologically enhanced excitation - a generator of pathologically enhanced excitation is formed.

At high generator power, a whole system of nonironal formations functioning in a single mode appears, which reflects a qualitatively new stage in the development of the disease; rigid connections between the individual components of such a pathological system underlie its resistance to various therapeutic effects. Studying the nature of these connections allowed G.N. Kryzhanovsky to discover new uniform intracentral relations and integrative activity of the central nervous system - the principle of the determinant.

Its essence is that the structure of the central nervous system, which forms the functional premise, subjugates those parts of the central nervous system to which it is addressed and forms a pathological system with them, determining the nature of its activity. Such a system is characterized by a lack of constancy and inadequacy of functional premises, i.e. such a system is biologically negative. If, for one reason or another, the pathological system disappears, then the formation of the central nervous system, which played main role, loses its determinant meaning.

Neurophysiology of movements

The relationship of individual nerve cells and their totality form complex ensembles of processes that are necessary for the full functioning of a person, for the formation of a person as a society, defines him as a highly organized being, which puts a person at a higher level. high level development in relation to other animals. Thanks to the highly specific relationships of nerve cells, a person can produce complex actions and improve them. Let us consider below the processes necessary to implement voluntary movements.

The act of movement itself begins to form in the motor area of the cape cortex. There are primary and secondary motor cortex. In the primary motor cortex (precentral gyrus, area 4) there are neurons that innervate the motor neurons of the muscles of the face, trunk and limbs. It has an accurate topographic projection of the muscles of the body. Projections are focused in the upper parts of the precentral gyrus lower limbs and torso, in the lower areas - upper limbs heads, necks and faces occupying most of the gyrus (Penfield’s “motor man”). This zone is characterized by increased excitability. The secondary motor zone is represented by the lateral surface of the hemisphere (field 6); it is responsible for planning and coordinating voluntary movements. It receives the bulk of efferent impulses from the basal ganglia and cerebellum, and is also involved in the recoding of information about complex movements. Irritation of the cortex of area 6 causes more complex coordinated movements (turning the head, eyes and torso to the opposite side, cooperative contractions of the flexor-extensor muscles on the opposite side). In the premotor zone, motor centers responsible for social functions human: the center of written speech in the posterior part of the middle frontal gyrus, Broca's motor speech center (area 44) in the posterior part of the inferior frontal gyrus, which provides speech praxis, as well as the musical motor center (area 45), which determines the tone of speech and the ability to sing.

In the motor cortex, the layer of large Betz pyramidal cells is better expressed than in other areas of the cortex. Neurons of the motor cortex receive afferent inputs through the thalamus from muscle, joint and skin receptors, as well as from the basal ganglia and cerebellum. Pyramidal and associated interneurons are located vertically in relation to the cortex. Such nearby neural complexes that perform similar functions are called functional motor columns. Pyramidal neurons of the motor column can inhibit or excite motor neurons of brainstem or spinal centers, for example, innervating one muscle. Adjacent columns functionally overlap, and pyramidal neurons that regulate the activity of one muscle are usually located in several columns.

The pyramidal tracts consist of 1 million fibers of the corticospinal tract, starting from the cortex of the upper and middle third of the precentral gyrus, and 20 million fibers of the corticobulbar tract, starting from the cortex of the lower third of the precentral gyrus (projection of the face and head). The pyramidal tract fibers end on the alpha motor neurons of motor nuclei 3-7 and 9-12 cranial nerves(corticobulbar tract) or on spinal motor centers (corticospinal tract). Through the motor cortex and pyramidal tracts, voluntary simple movements and complex goal-directed motor programs (professional skills) are carried out, the formation of which begins in the basal ganglia and cerebellum and ends in the secondary motor zone. Most fibers motor pathway crossed, but a small part of them goes to the same side, which helps compensate for unilateral damage.

The cortical extrapyramidal tracts include the corticorubral and corticoreticular tracts, starting approximately from the zones in which the pyramidal tracts begin. The fibers of the corticorubral tract end on the neurons of the red nuclei of the midbrain, from which the rubrospinal tract further begins. The fibers of the corticoreticular tract end on the medial nuclei of the reticular formation of the pons (the beginning of the medial reticular tract), and on the neurons of the giant cells of the reticular tract medulla oblongata, from which the lateral reticulospinal tracts begin. Through these pathways, tone and posture are regulated, ensuring precise movements. These extrapyramidal pathways are components of the extrapyramidal system, which also includes the cerebellum, basal ganglia, and motor centers of the brain stem; it regulates tone, balance posture, and performs learned motor acts such as walking, running, speaking, writing, etc.

Assessing in general the role of various brain structures in the regulation of complex goal-directed movements, it can be noted that the urge to move is created in the limbic system, the intention of movement is in the associative zone of the cerebral hemispheres, movement programs are created in the basal ganglia, cerebellum and premotor cortex, and the execution of complex movements occur through the motor cortex, motor centers of the brainstem and spinal cord.

Coordination activity (CA) of the CNS is the coordinated work of CNS neurons, based on the interaction of neurons with each other.

CD functions:

1) ensures clear performance of certain functions and reflexes;

2) ensures the consistent inclusion of various nerve centers in the work to ensure complex forms of activity;

Basic principles of CNS CD and their neural mechanisms.

1. The principle of irradiation (propagation). When small groups of neurons are excited, the excitation spreads to a significant number of neurons. Irradiation is explained:

1) the presence of branched endings of axons and dendrites, due to branching, impulses spread to a large number of neurons;

2) the presence of interneurons in the central nervous system, which ensure the transmission of impulses from cell to cell. Irradiation has boundaries, which are provided by the inhibitory neuron.

2. The principle of convergence. When a large number of neurons are excited, the excitation can converge to one group of nerve cells.

3. The principle of reciprocity - coordinated work of nerve centers, especially in opposite reflexes (flexion, extension, etc.).

4. The principle of dominance. Dominant– the dominant focus of excitation in the central nervous system at the moment. This is the center of persistent, unwavering, non-spreading excitation. It has certain properties: it suppresses the activity of other nerve centers, has increased excitability, attracts nerve impulses from other foci, sums up nerve impulses. Foci of dominance are of two types: exogenous (caused by environmental factors) and endogenous (caused by internal environmental factors). The dominant underlies the formation of a conditioned reflex.

1) positive feedback, causing an increase in the response from the nervous system. Underlies the vicious circle that leads to the development of diseases;

2) negative feedback, reducing the activity of CNS neurons and response. Underlies self-regulation.

6. The principle of subordination. In the central nervous system there is a certain subordination of departments to each other, the highest department being the cerebral cortex.

7. The principle of interaction between the processes of excitation and inhibition. The central nervous system coordinates the processes of excitation and inhibition:

1) consistent. The process of excitation and inhibition alternates in time;

The first level is ensured due to the fact that impulses from different neurons can converge on the body of one neuron, resulting in either summation or a decrease in excitation.

The second level provides interactions between individual groups of cells.

The third level is provided by cells of the cerebral cortex, which contribute to a more advanced level of adaptation of the activity of the central nervous system to the needs of the body.

Types of inhibition, interaction of excitation and inhibition processes in the central nervous system. Experience of I. M. Sechenov

Braking– an active process that occurs when stimuli act on tissue, manifests itself in the suppression of other excitation, there is no functional function of the tissue.

Inhibition can develop only in the form of a local response.

There are two types of braking:

a) presynaptic in the axo-axonal synapse;

b) postsynaptic in the axodendritic synapse.

a) transcendental, which occurs when there is a large flow of information entering the cell. The flow of information lies beyond the functionality of the neuron;

b) pessimal, which occurs with a high frequency of irritation;

c) parabiotic, which occurs during strong and long-term irritation;

d) inhibition following excitation, resulting from a decrease in the functional state of neurons after excitation;

e) inhibition according to the principle of negative induction;

e) inhibition of conditioned reflexes.

Modern interpretation of the experience of I.M. Sechenov (I.M. Sechenov irritated the reticular formation of the brain stem): excitation of the reticular formation increases the activity of inhibitory neurons of the spinal cord - Renshaw cells, which leads to inhibition of α-motoneurons of the spinal cord and inhibits the reflex activity of the spinal cord.

Methods for studying the central nervous system

There are two large groups of methods for studying the central nervous system:

1) experimental method, which is carried out on animals;

2) a clinical method that is applicable to humans.

To the number experimental methods classical physiology includes methods aimed at activating or suppressing the nerve formation being studied. These include:

1) method of transverse section of the central nervous system at various levels;

2) method of extirpation (removal of various parts, denervation of the organ);

3) method of irritation by activation (adequate irritation - irritation with an electrical impulse similar to a nervous one; inadequate irritation - irritation with chemical compounds, graded irritation with electric current) or suppression (blocking the transmission of excitation under the influence of cold, chemical agents, direct current);

Experimental methods are often combined with each other when conducting experiments.

Clinical method aimed at studying the physiological state of the central nervous system in humans. It includes the following methods:

1) observation;

2) method of recording and analyzing electrical potentials of the brain (electro-, pneumo-, magnetoencephalography);

3) radioisotope method (investigates neurohumoral regulatory systems);

4) conditioned reflex method (studies the functions of the cerebral cortex in the mechanism of learning and the development of adaptive behavior);

5) questionnaire method (assesses the integrative functions of the cerebral cortex);

6) modeling method (mathematical modeling, physical modeling, etc.). A model is an artificially created mechanism that has a certain functional similarity with the mechanism of the human body being studied;