The following were used as excipients:
- magnesium stearate (weight - 0.8 mg);
- lactose monohydrate (48 mg);
- corn starch (16 mg);
- pregelatinized corn starch(9.6 mg);
- povidone K 25 (1.6 mg);
- film coating (2 mg) – Opadry II white, as well as Colorcon 85G18490, which contains polyvinyl alcohol, soy, talc, titanium dioxide E 171 and macrogol No. 3350.
Release form
Available in white, round, biconvex tablets, they are film-coated and have “G63” engraved on one side. 21 tablets per blister, 1.3 blisters per pack.
pharmachologic effect
Possesses contraceptive effect with antiandrogenic and antimineralocorticoid properties.
Pharmacodynamics and pharmacokinetics
The contraceptive effect is based on the interaction of factors, among which inhibition is considered the most important ovulation and structural and functional changes.
Midiana is a combination oral thanks to active substances such as ethinylestradiol And drospirenone . In addition, drospirenone in a therapeutic dose has antiandrogenic and weak antimineralocorticoid properties, however, it does not have estrogenic, glucocorticoid, or antiglucocorticoid activity, which makes drospirenone similar in pharmacological profile to natural.
Relatively pharmacokinetics : The biotransformation of drospirenone and einyl estradiol occurs differently. Drospirenone is not completely absorbed when taken orally; bioavailability is within 76-85%, regardless of diet. Its maximum concentration in serum after the first dose is 37 nanograms per ml after several hours; in the first cycle, an equilibrium concentration of 60 nanograms per ml is established after 7-14 hours. The decrease in serum concentration occurs in 2 phases by binding to whey .
Contraindications
Midiana tablets cannot be prescribed for the conditions listed below, and also require discontinuation when they first develop while taking this drug:
- hypersensitivity to the constituent components;
- , arteries or thrombus , as well as hereditary or acquired predisposition to them;
- various harbingers: (TIA) or ;
- uncontrollable arterial hypertension ;
- complicated lesions of the heart valves;
- cerebrovascular diseases;
- surgery with long term immobilization (immobilization);
- smoking after 35 years;
- renal, liver failure, liver;
- risk factors for arterial thrombosis: severe arterial hypertension and dyslipoproteinemia , ;
- hyperhomocysteinemia ;
- , expressed hypertriglyceridemia ;
- deficiency: antithrombin III, protein C or S;
- severe forms and exacerbations of liver diseases until liver tests are completely normalized;
- suspected or established hormone-dependent malignant diseases of the reproductive system;
- bleeding from the vagina of unknown origin;
- or suspicion, ;
- deficiency of the enzyme lactase, galactosemia , glucose-galactose malabsorption.
Use with caution when dyslipoproteinemia , controlled arterial hypertension , chloasma , postpartum period.
Side effects
Frequency of occurrence of a spectrum of side effects: often - ≥ one in 100 to< одного на 10 пациентов; иногда (нечасто) - ≥ 1/1000 до < 1/100; редко - ≥ 1/10000 до < 1/1000 относительно органов и систем:
- Nervous system: often - and emotional lability, ; infrequently - a case of decrease libido ; rarely - increased libido occurred.
- Endocrine system: “often” - recorded pain in the mammary glands, cases of interruptions menstrual cycle, intermenstrual bleeding; rarely - galactorrhea .
- Sense organs: rarely - cases of hearing loss, poor tolerance of lenses.
- Digestive system: often - nausea, abdominal pain ; “sometimes” occurs - vomiting, .
- Leather: infrequently - acne , , , nodular or multiforme erythema , chloasma .
- The cardiovascular system: sometimes - a change in blood pressure in any direction; rarely - , thromboembolism .
- Complications of elimination: sometimes - fluid retention; “rarely” – weight loss was observed.
- The immune system: rarely - bronchospasm .
- Reproductive system: often - cases recorded acyclic vaginal bleeding (spotting bloody issues, breakthrough bleeding from the uterus), engorgement and enlargement of the mammary glands, vagina; infrequently - vaginitis ; rarely - galactorrhea , increased vaginal discharge.
Instructions for use (Method and dosage)
The tablets should be taken orally, with a small amount of water, every day (starting from the 1st day of the natural menstrual cycle, that is, menstrual bleeding) at approximately the same time in the sequence indicated on the blister: one tablet for 3 weeks, then requires a 7-day interval for onset menstrual-like bleeding .
When replacing with another combined oral contraceptive, vaginal ring or transdermal patch It is preferable to start using Midiana the day after consuming the last tablet or on the day of removing any of the previously used products.
You can switch to taking Midiana tablets on any day, on the day of removal of the implant or other intrauterine contraceptive, on the next day, and it is advisable to use additional ones in the first week.
If the pregnancy was terminated in the 1st trimester, then start taking it immediately without additional measures contraception if pregnancy is terminated in the 2nd trimester or baby is born, then the reception begins after 3-4 weeks. A longer interval requires the use of additional barrier methods of contraception in the first week. If sexual intercourse occurs, you should first completely exclude pregnancy or wait until your first menstruation.
Regimen for taking missed pills
If you are late in taking the pill within 12 hours, the contraceptive protection of the drug will decrease, so it is recommended to take the pill immediately and continue taking it as usual. If the delay is more than 12 hours, then further tactics When taking the drug, you should use 2 simple rules:
- You cannot stop taking the contraceptive for more than 1 week.
- To achieve adequate oppression hypothalamic-pituitary system functioning of the ovaries, a 7-day continuous intake of the drug is required.
The following recommendations will be useful in daily practice:
- In the first week, take the last missed dose as soon as possible, up to taking 2 tablets at a time. Subsequently, the tablets are taken as usual. set time However, it is recommended to additionally use barrier methods of contraception for 7 days, otherwise there is a risk of pregnancy, and it directly depends on the number of missed pills and the proximity to the 7-day break from taking the drug.
- In the second week, take the last missed dose as soon as possible and continue as usual. If the previous 7 days of use were correct, then you don’t have to use it. barrier contraception , but if more than 1 tablet is missed, then sexual intercourse without them is not advisable.
- In the third week, the likelihood of a decrease in the contraceptive effect is significantly increased, this is due to the upcoming 7-day missed pill intake. A decrease in contraceptive effect can be prevented by adjusting the drug dosing schedule. If the previous 7 days. the course was not interrupted, then you can do without barrier contraception, otherwise it is necessary and you must act in one of two ways. First: you should take the drug as soon as possible and continue as usual, then you need to start new packaging without a break between packs (most often no withdrawal bleeding is observed, but spotting or complications such as breakthrough uterine bleeding may occur). Second: stop taking tablets from the current package for 7 days for withdrawal bleeding, including missed days of dosing, then continue with a new package.
In order to delay withdrawal bleeding , it is necessary not to stop taking the drug, that is, not to take a break between packages. The delay can be until the end of the 2nd package, however, as the cycle lengthens, spotting bloody discharge from the vagina or complications in the form of breakthrough uterine bleeding may be observed. Then they resume taking it, starting with a new pack after a standard 7-day interval. To postpone the onset of withdrawal bleeding to another day, you need to shorten the next break by as much as necessary. Remember that the shorter the interval, the greater the risk of no withdrawal bleeding and spotting bleeding (or complications in the form of breakthrough uterine bleeding) when taking the 2nd pack.
If taking Midiana tablets is accompanied by severe reactions from the gastrointestinal tract, for example, vomiting or diarrhea , this means that the drug may not be completely absorbed, so it is recommended to additionally use other contraceptive measures. If an attack of vomiting occurs after taking the tablet 3-4 hours later, then you should take a new tablet as soon as possible. New pill If possible, should be taken within 12 hours of the usual dosing time. If more than 12 hours have passed, then in the future you need to act according to the rules of admission. If you do not plan to change the normal regimen, then take an additional one or more tablets from the next package.
Overdose
No cases of overdose have been recorded. Possible symptoms: nausea, vomiting, spotting or bleeding from the vagina. Assign symptomatic treatment. There is no specific one.
Interaction
Due to the interaction of oral contraceptives and others medicines breakthroughs may occur uterine bleeding and/or decreased contraceptive protection. The following types of interactions are known: tetracyclines) reduce enterohepatic recirculation of hormones, which may reduce ethinyl estradiol concentrations.
Terms of sale
Dispensed by prescription.
Storage conditions
Keep out of reach of children, in a dark place, at a temperature of no more than 25° Celsius.
Best before date
Two years.
special instructions
If you take any of the drugs listed in the first 3 points of the “Interaction” section with this medicine, then you need to use barrier methods of contraception or completely switch to other contraceptives. If you use drugs containing active substances, affecting microsomal liver enzymes, non-hormonal contraceptives should be used for 4 weeks after their discontinuation. When do you start taking it? concomitant drug at the end of taking a contraceptive package, then taking the next contraceptive package occurs without a 7-day interval.
Midiana and excess weight
No dialing excess weight, sometimes there is a removal of excess fluid. The drug does not affect body weight. If such a side effect occurs, it is better to consult your doctor.
With antibiotics
When taking (exception:,), you must also temporarily resort to barrier methods of contraception for at least another 7 days after their discontinuation.
During pregnancy and lactation
It is contraindicated to use Midiana during this period. If pregnancy occurs while using contraception, the drug should be discontinued immediately.
There is limited information about the lack of teratogenic effects and increased risk for the child and woman during childbirth with the unintentional use of combined contraceptives orally. In addition, they affect lactation and can reduce the amount and change the composition. breast milk, which can have harmful effects per child.
Analogs
Level 4 ATX code matches:- Simicia
- Dailla
The price of analogues does not differ significantly, most often Midiana contraceptives are replaced with the drug Yarina , since it is easier to find in pharmacies, although it is much more expensive.
Median birth control pills. Reviews show that this remedy not only allows you to avoid unwanted pregnancy, but even helps you get rid of several unnecessary kilograms. These low-dose contraceptive pills are prescribed to nulliparous girls, as well as women who have already given birth and women over 35 years of age. In some cases, Median is prescribed to provide a cosmetic effect.
The drug Mediana is a monophasic contraceptive, that is, each tablet contains an equal dose of hormones - 3 milligrams of drospirenone, as well as 0.03 milligrams of ethinloestradiol.
Why should you take the birth control pill Median? Reviews and advantages of the drug.
The drug contains the substance drospirenone, which has an antiadrogenic and cosmetic effect. That is, Median does not allow androgens (male sex hormones) to influence a woman’s body. Androgens are main reason appearance acne and strong sebum secretion. Thanks to the use of tablets, the functioning of the sebaceous glands of the skin is normalized, and the appearance of acne is reduced.
The drug also helps reduce symptoms of PMS, pain during menstruation, and even normalizes the menstrual cycle. The above-described effects are achieved only with regular use of Median for at least 2 to 3 months.
How to take the oral contraceptive Median correctly?
If you have never taken any birth control pills before, then the very first Median pill should be taken on the first day of menstruation. In this case, you don’t have to use condoms from the beginning of the course. You can also start taking Median tablets for 2 to 5 days of your period., only then it is necessary to use condoms for at least seven days from the start of the course.
It is recommended to take the tablets daily at a certain time, regardless of meals. Minor deviations from time are not critical. If the delay in taking does not exceed 12 hours, this does not reduce the effect of the drug.
It is recommended to take Median in the order indicated on the blister, but this is not a strict rule. Each tablet contains an equal dose of the hormone, and therefore the order of administration, in general, is not important. The main thing is to strictly drink one tablet every day. When the Mediana blister runs out, you must wait seven days before the next course. During this week, period-like bleeding may begin.
The next package must be taken on the eighth day after a seven-week break. In addition, it does not matter whether your period began or ended at the time you started taking the new package.
How to switch to Median tablets after other contraceptives and medications? Reviews from doctors.
If you took other birth control pills in the past month, then you need to adhere to some specific rules, to switch to Median tablets (package price is about 810 rubles). If the previous pack contained 28 tablets, then you can start taking Median the next day. And if the blister contained 21 tablets, then it is better to take a week break before taking Median. In addition, during the first seven days of taking the pills, it is advisable to use additional contraceptives.
After removing the vaginal ring or hormonal patch, the Mediana tablet should be taken on the same day. When switching from an IUD, you should take the first tablet on the day the IUD was removed, and then use additional means to prevent pregnancy for a week.
Similar interesting articles.
The combined oral contraceptive Midiana contains ethinyl estradiol and drospirenone. The contraceptive effect of these contraceptives is to suppress ovulation and change the endometrium, against the background of which, even in the case of fertilization, the egg will not be able to implant safely.
Indications for use of the drug Midiana.
The main indication for the use of these contraceptives is to prevent the onset of unplanned pregnancy.
Method of use of the drug and dosage.
The tablets should be taken one at a time every day, according to the sequence of the blister, with a sufficient volume of liquid. The package contains twenty-one active tablets. After they run out, you should take a week's break, and then start a new pack. Usually, during a seven-day break in taking the drug (after two to three days), menstrual-like bleeding occurs, which may not end by the time you start taking the drug from a new package.
Reception contraceptive Midiana should be started on the day the woman's menstrual cycle begins (on the first day of her period), provided that no other combined oral contraceptives have been used up to this point.
When switching to Midiana contraceptives from another oral contraceptive, the drug should be taken the next day (no later than) after taking the last active tablet of the previous oral contraceptive. In such cases, Midiana should be taken no later than the next day after the usual one-week break in taking or taking so-called placebos (“dummies”) of the previous oral contraceptive drug.
When switching to hormonal drug It is recommended to start using Midiana with a vaginal ring or transdermal patch on the day of removal of the hormonal ring or on the day of replacing the transdermal patch with a new one.
When switching to these contraceptive pills from a mini-pill, you can start taking the drug on any day of the cycle, when switching from injections - on the day of a new injection, from implants or intrauterine contraceptives - on the day of removal. However, in all cases, during the first seven days of taking the drug, you should use additional means of protection (condom).
After an abortion in the first trimester, a woman can start taking oral contraceptives Midiana immediately. In this case, additional protection against unwanted pregnancy is not required.
After childbirth or abortion in the second trimester, taking Midiana contraceptives should be started 21-28 days after childbirth or abortion in the second trimester. If you start taking the drug later, you should additionally use barrier contraception during the week of taking the drug. If you have sexual relations before taking the drug, it is recommended to exclude pregnancy, or wait until your period begins.
What a woman should do if she misses a dose.
If less than twelve hours have passed since the drug was missed, contraceptive effectiveness is not reduced. In this case, the tablet should be taken as soon as possible, and the next one should be taken according to the usual dosage regimen.
If taking the pills was missed for more than twelve hours, the contraceptive effect is significantly reduced, because to suppress the hypothalamic-pituitary function of the ovaries, continuous seven-day use of the contraceptive is necessary. IN in this case The following recommendations should be followed:
- If you miss taking the drug during the first week of taking it, you should immediately (as soon as you remember) take the missed pill. If the dose coincides with the next tablet, simultaneous administration of two tablets is allowed. The next tablet is taken at usual time. In this case, it is necessary to additionally protect yourself with a condom for seven days.
- If a drug is missed in the second week of the cycle, you should also immediately take the missed tablet (if necessary, taking two tablets at once is allowed), and take the next one at the usual time. If the drug has been used correctly over the previous seven days, then there is no need to use additional means of protection, but if a pill or more was missed in the previous week of taking the drug, it is recommended to additionally use a condom for the next seven days.
- If a drug was missed in the third week of the cycle, the likelihood of contraceptive effect significant against the background of the upcoming week-long break in admission. In this case, if the drug was taken correctly within seven days before skipping, then additional contraception is not needed, otherwise you need to follow the first of the above methods and additionally use a condom for next week. You must take the missed tablet, even if you have to take two tablets at once, and take the next one at the usual time. In this case, a new package of the drug must be started without a seven-day break in taking it. In most cases, withdrawal bleeding will occur at the end of the second package of the drug. However, spotting or breakthrough uterine bleeding may occur during this period.
If vomiting or diarrhea occurs while taking the drug, it is necessary to use additional means of protection against unwanted pregnancy, since absorption of the tablet will not be complete. If vomiting or diarrhea occurs, three to four hours after taking the drug, it is recommended to take another tablet, if possible within twelve hours after the usual time of administration.
How to delay withdrawal bleeding?
To do this, you need to start a new package of the drug without a seven-day break. A delay is possible until the end of the tablets in the second package.
Side effect.
Most often occur headache, migraine, nausea, abdominal pain, emotional mood swings, menstrual irregularities, pain in the mammary glands, intermenstrual bleeding, vaginal candidiasis, weight gain, soreness and enlargement of the mammary glands. These are much less common side effects such as decreased libido, vomiting, itching, diarrhea, acne, eczema, urticaria, skin rash, erythema and its forms, increase or decrease blood pressure, fluid retention, vaginitis.
Contraindications to taking the drug:
- smoking by patients over 35 years of age;
- thrombosis in history or present, as well as predisposition to them;
- major surgery;
- uncontrolled arterial hypertension;
- liver failure, severe liver disease;
- the presence of risk factors for the development of thrombosis;
- diabetes;
- arterial hypertension in severe form;
- severe dyslipoproteinemia;
- cerebrovascular diseases;
- pancreatitis;
- liver tumors;
- hormone-dependent diseases of the reproductive system of a malignant nature;
- pregnancy or suspicion of it;
- lactation period;
- individual intolerance to the components of the drug;
- bleeding from the vagina for unknown reasons;
- migraine.
Use of the drug Midiana during pregnancy and breastfeeding.
During pregnancy and lactation, taking Midiana is contraindicated. If pregnancy occurs while taking data birth control pills you should stop taking it immediately. According to available research, pregnant women who took the drug unintentionally gave birth to healthy babies. No harmful effects on the fetus were detected. However, these contraceptives affect lactation and change the amount and composition of breast milk. The components contained in birth control pills pass into milk and may have Negative influence per child. It is possible to resume taking the drug only after the period of breastfeeding has completely stopped.
The search for new safe and effective means contraception. Pharmaceutical companies New developments are regularly carried out in this area, which primarily concerns birth control pills.
And if just a few decades ago birth control pills had a considerable list of side effects, which caused particular concern among women, today pharmacology is more successful in this area.
The market is constantly updated with new developments, which also include the Median birth control pill. These are low-dose contraceptive pills prescribed to nulliparous and parous women, as well as to women over the age of 35.
Birth control pills median
Median can also be prescribed to achieve a cosmetic effect. This drug is a monophasic contraceptive - all tablets contain the same dose of hormones (3 milligrams of drospirenone and 0.03 milligrams of ethinyl estradiol).
Pros of Median
Drospirenone, which is part of Median, has a cosmetic antiandrogenic effect. This means that the pills prevent the influence of male sex hormones (androgens) on the woman’s body. Androgens are considered one of the main causes of acne and excessive sebum production. Median helps normalize skin function sebaceous glands and reduce the appearance of acne.
This drug also helps to reduce PMS symptoms, pain during the period before and after menstruation, and also helps normalize the menstrual cycle. All these effects are achieved by regularly taking Median for at least two or three months.
Median tablets instructions
If you have not previously taken birth control pills, take the first pill on the first day of your period. In this situation, you can stop using condoms from the start of taking Median.
The start of taking pills can also be carried out during the period from the second to the fifth day of menstruation, but in this situation, condoms must be used for another week after the first pill.
It is recommended to take the median every day “on an alarm clock” at the same time, without attachment to food intake. However, small deviations are not considered dangerous in principle. If you are no more than 12 hours late to take the next pill, the effect of the drug will not decrease.
The tablets are taken in the order indicated in the instructions, but this is not a strict rule. All median tablets contain an equal dose of hormones, which is why the order of administration is not important. It is also important to take one tablet per day.
At the end of the tablets in the blister, a seven-day break is required, during which the tablets are not taken. During this time, withdrawal bleeding may occur, similar to a period.
The next package begins to be taken on the eighth day after the break. By the way, with all this, it does not matter at all whether menstruation has begun or has ended by the time the next package is taken.
Switching from other contraceptives
If you decide to switch to Median from any other birth control pills, you need to follow some recommendations.
1. If the blister of the previous drug contained 28 tablets, you should start drinking Median the day after the last tablet in the blister of the previous drug.
2. If the blister of the previous drug contained 21 tablets, start drinking Median after finishing taking the previous drug or after a break on the next day.
Even during the first week of taking the median, experts advise using additional protection.
Switching to Median from an IUD, vaginal ring or hormonal patch
In this situation, the first tablet of Mediana is taken on the day of removal of the vaginal ring or removal of the hormonal patch. You can also start taking the drug on the day when you would need to attach a new patch or install a vaginal ring. To avoid pregnancy, it is recommended not to neglect taking the pills during the week. additional methods contraception.
When switching to Median with an IUD, you must start taking the drug on the day the IUD is removed, and then you need to take additional protection for another week.
Median after abortion
In case of an abortion before 12 weeks of pregnancy, Median should be taken on the day of the procedure. In the case of an abortion at a period of more than 12 weeks, the median is taken at 21-28 days after the abortion. For another week you take additional protection.
If unprotected sexual intercourse took place between the abortion and taking the drug, pregnancy must be excluded before taking the drug.
Median after birth
After childbirth, the drug can be taken only if the woman is not breastfeeding. The fact is that there are other special medications for nursing mothers that cannot harm the baby. Therefore, it is recommended to consult a gynecologist regarding this issue.
If a woman is not breastfeeding, the drug can be started 21-28 days after birth. If you have unprotected sexual intercourse before taking the drug, it is important to make sure that there is no pregnancy.
Skipping a pill
If the delay in taking the next pill is no more than 12 hours, then the effectiveness of the drug does not suffer from this. If the delay is more than 12 hours, you need to take into account which pill you missed.
If it is tablets 1 to 7, take the missed tablet as soon as you remember, even if you need to take two tablets at the same time. After this, you need to use other contraceptives for a week.
If it is tablet 8 to 14, the missed tablet is taken even if you need to take two tablets at once. After this, if 7 days before the pass everything was done according to the rules, without passes, it is not necessary to use condoms.
If there were other absences during the previous week before the pass, you will have to use condoms for another week.
If this is a tablet from 15 to 21, you must, as in other cases, take the missed tablet, finish the blister to the end, and then start a new blister without a break of seven days. If there were no other passes before this pass, additional security measures do not need to be used.
If during the previous week there were certain errors in taking the pills, you should take additional precautions for another week.
Skipping several pills
If you miss several tablets in a row, you need to take two tablets for two days. So in two days you will catch up with all the pills needed for the bill. If you miss three tablets in a row, you will have to take two tablets for three days.
If you miss four or more tablets, you must additionally consult with a specialist about your further actions.
If you miss several tablets in a row, additional protection must be used for 7 days after resuming taking the drug.
One or two days after skipping, you may experience breakthrough bleeding, which is similar to menstruation, or spotting. Don't be afraid, because it's not dangerous. You need to continue taking the pills according to the instructions, and this discharge will stop on its own.
Breaks in taking Median - are they necessary or not?
There is an opinion that approximately once every 6-12 months it is necessary to take a 1-2 month break from taking birth control pills. But this is not true.
Significant breaks in taking the drug will not bring any benefit to the body, since this is significant stress for the ovaries.
As studies on this topic have shown, Median can be taken for up to 5 years in a row, without long breaks. This doesn't affect the probability at all. future pregnancy. You can conceive a baby almost immediately after stopping the pills.
If you take a break for a month, the likelihood of getting pregnant during the period of stopping the pills increases. To avoid pregnancy, you must use condoms. At the same time, it is necessary to remember that interrupted sexual intercourse is unreliable in terms of protection against pregnancy, so this method should be abandoned.
After a break, many women suffer from cycle disorders, delayed menstruation, hair loss, acne, as well as deterioration in health and other symptoms. That's why if you take breaks like this, to such side effects you need to be ready.
Median and other medications
The contraceptive effect of Median may decrease while taking certain medications, and this, in turn, may end unwanted pregnancy. We are talking about antibiotics (penicillins, tetracyclines, Rifampicin), drugs for epilepsy (Phenytoin, Carbamazepine), sleeping pills (Phenobarbital), drugs used in the treatment of fungal infections (Griseofulvin) and drugs containing St. John's wort (Novo-passit), etc. .
A decrease in the effectiveness of the drug when taking these medications can cause spotting or even breakthrough bleeding. This is not dangerous, so you should not deviate from the schedule for taking Mediana. During the treatment period, as well as seven days after its completion, additional protection should not be neglected.
Median and alcohol
Small doses of alcohol do not affect the effectiveness of the drug. But permissible norm alcohol intake depends on metabolism, age, weight and other factors. On average, during the course of taking Median, no more than 50 milliliters of vodka, 200 milliliters of wine and 400 milliliters of beer are allowed. If the specified dose is exceeded, it is worth protecting yourself for an additional 7 days after drinking alcohol.
How to take birth control pills
If there is a need to delay menstruation after finishing one blister of the drug, you must start the next blister the very next day, without taking a week's break, and finish it to the end. In this situation, menstruation will be delayed by about 2-4 weeks, but it is possible that spotting will appear in the middle of taking the next blister.
It must be remembered that menstruation can be delayed only if the drug was started at least a month before the delayed period.
If there is no menstruation during the seven-day break
If you took the drug in the previous month according to the rules, there is no reason to worry. In this case, menstruation may well not come during the break, which is not dangerous. You just need to start a new pack, even if you haven’t had your period. If menstruation does not occur in the next month, you need to take a pregnancy test and go to the gynecologist.
If you missed pills during the previous month, or if you took drugs that reduce the effectiveness of Median, it is not recommended to start the next pack after a week's break. First, you need to take a pregnancy test and do not resume taking the drug until you completely rule out the possibility of pregnancy.
If pregnancy occurs while taking Mediana, you should immediately stop taking the pills and see a gynecologist.
Reception of the Median on early stages pregnancy cannot provoke fetal development abnormalities, so the pregnancy can be saved. You will just need to start taking folic acid as soon as possible.
