In this article you can find instructions for use medicinal product Fervex. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Fervex UPSA in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Fervex in the presence of existing structural analogues. Use to treat cold symptoms in adults, children, and during pregnancy and lactation. Composition and interaction of the drug with alcohol.
Fervex - combination drug for symptomatic treatment of acute respiratory infections and acute respiratory viral infections.
Paracetamol is an analgesic-antipyretic, has an analgesic and antipyretic effect, which is associated with its effect on the thermoregulation center in the hypothalamus; eliminates headaches and other types of pain, reduces fever.
Ascorbic acid (vitamin C) is involved in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, in the synthesis of GCS, collagen and procollagen; normalizes capillary permeability. Increases the body's resistance, which is associated with stimulation immune system.
Pheniramine is a histamine H1 receptor blocker, reduces rhinorrhea, nasal congestion, sneezing, lacrimation, itching and redness of the eyes.
Compound
Paracetamol + Pheniramine maleate + Ascorbic acid + excipients.
Paracetamol + Ascorbic acid + Dextromethorphan bromide + excipients (Fervex for dry cough).
Chlorhexidine gluconate + excipients (for sore throat).
Paracetamol + Pseudoephedrine hydrochloride + Chlorpheniramine maleate + excipients (Fervex rhinitis).
Indications
- ARVI (symptomatic therapy);
- rhinitis and nasopharyngitis of infectious-inflammatory and allergic nature.
Release forms
Powder for the preparation of solution for oral administration.
Powder for preparing a solution for oral administration (for children).
Lozenges (for sore throat).
Tablets for making an effervescent drink (for dry cough).
Film-coated tablets (rhinitis).
Instructions for use and method of use
Powder for preparing solution
Fervex is prescribed orally, 1 sachet 2-3 times a day, preferably between meals. The interval between doses of the drug is at least 4 hours.
The duration of treatment (without consulting a doctor) is no more than 5 days when used as analgesic and no more than 3 days - as an antipyretic.
The drug should be completely dissolved in a glass of warm water and the resulting solution should be drunk immediately.
Powder for preparing a solution for children
The drug is prescribed orally. The dose depends on the age of the child:
- children from 6 to 10 years old - 1 sachet 2 times a day;
- children from 10 to 12 years old - 1 sachet 3 times a day;
- children from 12 to 15 years old - 1 sachet 4 times a day.
The interval between doses of the drug is at least 4 hours. The duration of treatment is no more than 5 days.
Before use, the contents of the sachet should be dissolved in a glass (200 ml) of warm water.
Lozenges
Orally, after meals, 1 tablet (keep in the mouth until completely absorbed) 3-4 times a day.
Effervescent tablets
Inside, dissolve the tablet in 150 ml of hot (not boiling) water, repeat the dose after 6-8 hours, but no more than 4 times a day.
Rhinitis tablets
Orally, 2 tablets every 6 hours, but not more than 8 tablets per day. For children under 12 years of age it is prescribed by a doctor.
Side effect
- nausea;
- pain in the epigastric region;
- dry mouth;
- anemia, thrombocytopenia, methemoglobinemia;
- urinary retention;
- with long-term use in doses significantly higher than recommended, the likelihood of renal dysfunction increases;
- skin rash;
- hives;
- Quincke's edema;
- drowsiness.
Contraindications
- erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
- renal failure;
- portal hypertension;
- chronic alcoholism;
- deficiency of glucose-6-phosphate dehydrogenase;
- children under 15 years of age;
- 1st and 3rd trimesters of pregnancy;
- lactation period (breastfeeding);
- hypersensitivity to the components of the drug.
Use during pregnancy and breastfeeding
The use of the drug is contraindicated in the 1st and 3rd trimesters of pregnancy and during lactation (breastfeeding).
Use in children
Contraindicated for children under 15 years of age.
special instructions
If it is necessary to take metoclopramide, domperidone or cholestyramine while using Fervex, the patient should consult a doctor.
During the use of Fervex, distortion of indicators is possible laboratory research at quantification concentrations uric acid and plasma glucose.
To avoid toxic damage liver paracetamol should not be combined with alcohol intake, and should not be taken by persons prone to chronic alcohol consumption.
When using the drug, the risk of developing liver damage increases in patients with alcoholic hepatosis.
With long-term use in doses significantly higher than recommended, monitoring of the peripheral blood picture is necessary.
Use in patients diabetes mellitus
The drug in the form of a powder for the preparation of a solution for oral administration of lemon does not contain sugar and can be used in patients with diabetes mellitus.
1 sachet of the drug in powder form for the preparation of a solution for oral administration of lemon with sugar or raspberry with sugar contains 11.5 g of sugar, which corresponds to 0.9 XE. This should be taken into account if it is necessary to use this dosage form in patients with diabetes mellitus or in patients on a diet with reduced content Sahara.
Drug interactions
Antidepressants, antiparkinsonian drugs, antipsychotic drugs (phenothiazine derivatives) - increase the risk of developing side effects(urinary retention, dry mouth, constipation) Fervexa.
When used simultaneously with Fervex, glucocorticosteroids (GCS) increase the risk of developing glaucoma.
Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which makes it possible to develop severe intoxication with a small overdose of the drug.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic action of paracetamol.
Paracetamol reduces the effectiveness of uricosuric drugs.
Ethanol (alcohol) contributes to the development of acute pancreatitis.
Ethanol (alcohol) enhances the sedative effect of antihistamines.
Analogues of the drug Fervex
Structural analogues according to active substance:
- Fastorik;
- Febricet;
- Fervex for children;
- Flucoldin.
Analogues pharmacological group(anilides in combinations):
- Adjikold;
- AnGriCaps maxima;
- Antigrippin;
- AntiFlu;
- AntiFlu Kids;
- Brustan;
- Gevadal;
- Influenza;
- Grippostad;
- Grippostad Good Knight;
- Grippostad S;
- GrippoFlu for colds and flu;
- Grippoflu extra for colds and flu;
- Gripend;
- Daleron C;
- Children's Tylenol for colds;
- Dolaren;
- Ibuklin;
- Influblock;
- Influnet;
- Caffetin;
- Codelmixt;
- Coldact Flu Plus;
- Coldrex;
- Coldrex Knight;
- Coldrex Hotrem;
- Coldrex Junior Hot Drink;
- Coldfree;
- Coffedon;
- Maxicold;
- Maxicold Rhino;
- Meksavit;
- Migraine;
- Migrenol;
- Mulsinex;
- Next;
- Neoflu 750;
- Novalgin;
- Padevix;
- Panadeine;
- Panadol Extra;
- Panoxen;
- Paracodamol;
- Paralen extra;
- Paracetamol Extra;
- Paracetamol Extra for children;
- Pentalgin;
- Pentaflucin;
- Plivalgin;
- Cold;
- Prohodol forte;
- Rinza;
- Rinzasip;
- Rinzasip with vitamin C;
- Rinicold;
- Saridon;
- Solpadeine;
- Stopgripan;
- Stopgripan forte;
- Strimol plus;
- Tylenol for colds;
- TeraFlu;
- TheraFlu for flu and colds;
- TheraFlu Extra;
- TheraFlu Extratab;
- Fastorik;
- Femizol;
- Fervex for dry cough;
- Fervex rhinitis;
- Flucoldin;
- Flucoldex;
- Flucomp;
- Flustop;
- Khairumat;
- Efferalgan with vitamin C;
- Unispaz.
If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.
Fervex is a popular, highly effective, complex drug that provides therapeutic effect in the presence of the main manifestations of colds and flu. Manufactured and available in powder form for subsequent preparation of a solution. The main components of Fervex are: paracetamol and ascorbic acid. The medicine should be taken by adults and children from the age of six when the first symptoms of the disease appear.
Shelf life – 3 years. Basic storage conditions are related to compliance temperature regime up to 25 degrees Celsius.
Release form
Fervex is produced in France, pharmaceutical company Bristol Myers Squibb, in the following forms:
- lemon-flavored powder, for subsequent solution, is taken orally. Available in cardboard packaging, which can contain 6, 8, 12 or 16 bags. One sachet contains 500 ml of paracetamol, 25 mg of pheniramine maleate and 200 grams ascorbic acid. It dissolves quickly, has a mild, pleasant lemon taste, and colors the water a characteristic yellow color.
- Raspberry flavored powder, taken orally. There are 6 or 8 sachets in a package.
- Banana-flavored powder for subsequent preparation of a solution for children. Only 6 or 8 sachets per box. One sachet contains: 280 mg of paracetamol, 10 mg of pheniramine maleate and 100 mg of ascorbic acid.
Pharmacological properties
Fervex is intended to relieve symptoms of flu and colds. One of the main components, paracetamol, is known for its antipyretic and anesthetic properties. It successfully eliminates dental and headache, normalizes body temperature.
Vitamin C or ascorbic acid has a beneficial effect on blood clotting, tissue renewal, vascular patency, and stabilizes the process of catalytic oxidation and carbohydrate metabolism. It has a stimulating effect on human immunity.
Pheniramine - affects histamine receptors, blocking, reducing allergies, redness of the eyes, reducing lacrimation, sneezing, swelling and nasal congestion.
Indications for use
The appearance of symptoms of influenza and any other acute respiratory viral infection. Fervex is used in the treatment of adults and children from 6 years of age. The medicine should be used after the following symptoms appear:
- sneezing;
- nasal congestion;
- headache;
- lacrimation;
- increase in body temperature.
To prepare the solution, pour the powder into a glass of warm, boiled water, stir thoroughly and drink. It is recommended to take one hour after meals. The interval between doses is at least 4 hours. If the functioning of the kidneys and liver is impaired, as well as for the elderly, the interval between doses is at least 8 hours.
Fervex, basic instructions for use:
- adults need to drink from 2 to 4 sachets per day, dissolving the powder in warm water.
- Children's Fervex is designed for ages from 6 to 15 years. Single dose is equivalent to taking one sachet. Children from 6 to 10 years old drink twice a day, from 10 to 12 three times a day, from 12 to 15 years old - from 3 to 4 times a day.
If the drug is taken without a doctor’s prescription, treatment should not last more than 3 days to normalize the temperature, and up to 5 days as a pain reliever.
Contraindications, overdose and side effects
It is prohibited to combine Fervex, alcoholic beverages and sedatives. Main contraindications for use:
- individual intolerance to one of the components of the drug;
- severe kidney and liver diseases;
- intraocular pressure (glaucoma).
Adverse reactions manifest themselves in the form of dry epithelium of the oral mucosa, decreased visual acuity, hallucinations, urinary retention, nervous excitability. Uncommon manifestations include skin rashes, urticaria, thrombocytopenia. Exceeding the dosage leads to the formation of drug-induced hepatitis.
The following symptoms indicate a drug overdose: nausea, vomiting, dizziness, pale skin, loss of appetite.
During pregnancy and lactation
It is forbidden to treat with Fervex in the first and third trimester of pregnancy, as well as during breastfeeding. The effect of the drug on the fetus has not been fully studied.
Drug interactions
It is prohibited to combine Fervex with psychotropic, antipsychotics and drugs for the treatment of Parkinson's disease. Their interaction leads to symptoms similar to those of an overdose.
The presence of alcohol in the blood increases the risk of developing acute pancreatitis.
Analogues
Medicines similar in composition are Febricet, Fastoric. By effectiveness: Antiflu, Coldfree, Apap, Ifimol.
Cheap analogues of Fervex are Prostudox and AnviMax, Antigrippin in the form of effervescent tablets.
Efficiency and reviews
Fervex is quite affordable and effective drug. It has a pleasant taste, is easy to dose, rarely causes adverse reactions, and begins to act within 30 minutes. The effectiveness of Fervex treatment is confirmed by many consumers.
Anna, Voronezh: “Our family is used to spending weekends actively, even in winter. It is not always possible to avoid hypothermia or crowded places. At the first signs of a cold, runny nose, headache, or sneezing, I immediately drink Fervex. It’s very convenient that there are many sachets in one box, so you don’t need to run to the pharmacy to get it in two days. After an hour, significant relief is felt, the headache no longer hurts, and the nasal discharge becomes much less. The drug is effective, but it seems to me that it is only suitable for relieving unpleasant symptoms.”
The following summary of Fervex is abbreviated and introductory.
Price in online pharmacy website: from 170
Pharmacological properties
The drug Fervex has antipyretic, analgesic and antihistamine effects. Represents a comprehensive combination remedy, consisting of paracetamol, ascorbic acid and pheniramine.
Properties of the main components of the product
Paracetamol is a medicinal substance that exhibits analgesic (non-narcotic) and antipyretic effects. Included in the group of anilides. It has the properties of blocking the activity of both forms of cycloogenase involved in the synthesis of prostanoids (prostaglandins, prostacyclins and thromboxanes), which causes inhibition of prostaglandin synthesis reactions. The effect of the substance is localized to a greater extent in the central region nervous system, in particular on the pain and thermoregulation center.
Peroxidase of cells of peripheral tissues neutralizes the effect of paracetamol on cyclogenase, which blocks the anti-inflammatory effects of the active substance. Medicinal component does not have a negative effect on mucous membranes gastrointestinal tract and on reactions water-salt metabolism in organism.
After oral administration, the substance is actively and quickly absorbed from the gastrointestinal tract. Achieving maximum concentration occurs within ten minutes to one hour. It has the properties of rapid distribution in tissues and penetrates the blood-brain barrier. Binding to plasma proteins is insignificant, but tends to increase with increasing dosage.
Metabolic processes occur in the liver, about eighty percent of the consumed amount enters into conjugation reactions with sulfates and glucuronic acid to form inactive derivatives. About seventeen percent is hydroxylated to produce eight active metabolites, one of which can have hepatotoxic effects and has cumulative properties when the therapeutic dosage is exceeded. When taking the drug in the prescribed amount, there is no hepatotoxicity and accumulation, which is explained by the neutralization of the metabolite in the process of combining with glutathione. Removal medicinal substance happens with the help urinary system in a metabolic form. The half-life is one to three hours.
Pheniramine is a substance that blocks the activity of n1-histamine receptors, reduces exudative and spastic manifestations, reduces swelling and hyperemic manifestations on the mucous membranes of the nasal cavity, oropharynx and paranasal sinuses.
After oral administration, it is actively absorbed from the gastrointestinal tract, the maximum therapeutic concentration is achieved within one to two and a half hours, duration therapeutic effect- about twenty-four hours. The half-life of the active substance is from sixteen to nineteen hours. Excretion occurs through the urinary system (about 70 - 83%).
Ascorbic acid exhibits pronounced restorative properties and is part of the group of water-soluble vitamin substances. Takes part in oxidation-reduction reactions, metabolism of carbohydrates and amino acids, participates in the metabolic reactions of thyroxine, catecholamines, steroid hormones, insulin, collagen and procollagen. It has a regenerative effect on connective and bone tissues. Helps improve capillary permeability, absorption of iron-containing compounds, and hemoglobin metabolism activity. The acid is necessary for the activity of blood clotting processes, and also increases the nonspecific resistance of the body and exhibits antidote properties. A deficiency of this substance can lead to hypo- and avitaminosis of vitamin C, since human body does not produce ascorbic acid.
After oral administration, ascorbic acid is absorbed in the gastrointestinal tract (in small intestine). Absorption processes can be disrupted due to certain pathologies of the stomach and intestines, with worms, as well as after consuming alkaline drinks, fresh fruit and vegetable juices. The maximum therapeutic concentration is reached within four hours. The active substance has the properties of active penetration into blood cells (leukocytes and platelets), and then into all tissues of the body.
Next, the process of acid deposition occurs in various areas of the body. Metabolic processes take place primarily in the liver, with conversion to desoascorbic acid, and subsequently to oxaloacetic and diketogulonic acid. The acid has the properties of penetrating the secretion of the mammary glands. The substance is eliminated through the urinary system and excretion. With an increased dosage, excretion activity increases sharply, and does not decrease immediately after cessation of use.
Indications for use
The drug Fervex is used for diseases caused by acute respiratory infections, as well as for rhinopharyngitis for relief general condition patient and the development of the following symptoms:
- With increased formation of mucus in the nasal area, as well as with a feeling of nasal congestion.
- For headaches.
- When the patient's body temperature increases.
- If you experience watery eyes and sneezing caused by acute respiratory infections.
Contraindications
The following situations are contraindications for the use of the drug Fervex:
- The presence of hypersensitivity or individual intolerance to the components included in the composition of the medicinal product.
- The presence of lesions of the gastrointestinal tract of an erosive-ulcerative type of an acute nature.
- Pathologies of functional activity of the liver.
- The presence of angle-closure glaucoma.
- Pathologies of the functions of the prostate and urinary system, causing a delay in the process of urination.
- Presence of portal hypertension.
- Alcohol abuse and alcoholism.
- Availability hereditary diseases(phenylketonuria), belonging to the group of enzymopathies, which is caused by a violation of amino acid metabolic processes (in particular phenylalanine).
- Pregnancy period, since there is no data on carrying out clinical trials confirming the safety of the drug for intrauterine development fetus and health of the expectant mother.
- Period breastfeeding, since there is no data on clinical trials confirming the safety of the drug for the health of the infant.
- Age indicators up to fifteen years.
Fervex therapy is carried out with extreme caution if there is congenital pathologies associated with hyperbilirubinemia, with hepatitis of a viral or alcoholic nature, as well as with the elderly patient.
Side effects
Usually the drug is well tolerated, but during the therapeutic course the following may develop: negative manifestations side effects:
Digestive system. Nausea, digestive dysfunction, pain in the epigastric region, dryness in the oral cavity. When therapy is carried out at a dosage significantly exceeding the maximum therapeutic dose, liver function disorders may develop.
Hematopoietic system. In rare cases, anemia, thrombocytopenia and methemoglobinemia may develop.
Urinary system. In rare cases, urinary retention may develop. When therapy is carried out at a dosage significantly exceeding the maximum therapeutic dose, renal dysfunction may develop.
The immune system. Allergic reactions may occur, manifested in the form of rash, itching, redness skin, as well as angioedema.
The cardiovascular system. It is possible to develop a feeling of palpitations, a state of dizziness, disorders of coordination functions, and fogginess of consciousness. As well as disorders of concentration functions (more often in elderly patients).
Miscellaneous. In rare cases, accommodation paresis may develop, as well as drowsiness.
If negative manifestations develop, it is necessary to interrupt therapy and seek advice from a specialist.
Dosage and method of use
The drug is used orally.
The standard dosage is one sachet twice or three times a day.
The powder contained in the package must be dissolved in a glass of boiled and cooled water.
The maximum daily dosage is 4 grams of the active substance (eight sachets) for a patient weighing more than fifty kilograms.
If the patient’s condition does not improve after five days of therapy, the therapy should be interrupted and consult a medical specialist.
Overdose
In case of overdose, it is possible to develop acute poisoning, manifested in the following symptoms: complete absence loss of appetite (anorexia), feeling of nausea, pain in the epigastric region, increased sweating, paleness of the skin, drowsiness. After a few days, damage to liver function may develop. In case of severe overdose, manifestations of liver failure, hepatonecrosis, encephalopathy, convulsive symptoms and, in extreme cases, may develop comatose state leading to the death of the patient.
In case of overdose, you should immediately stop taking the drug and consult a medical specialist for help.
For treatment, gastric lavage, the use of enterosorbents, and the use of an antidote, acetylcysteine, should be performed.
Subsequently, symptomatic therapy is carried out.
Features of use
The drug is available in several varieties, with and without sugar; for patients with diabetic diseases, it is necessary to carefully look at the composition of the product.
In case of therapy with an increased dosage of the drug, mental dependence may occur. To avoid an overdose, it is necessary to take into account the amount of the substance taken per day, which should not exceed four grams.
If simultaneous use with metoclopramide, domperidone and cholestyramine is necessary, you should consult a specialist before starting therapy.
During therapy medicine There may be a distortion of the indicators obtained during clinical trials to determine the level of urea and glucose in the blood.
The use of a medication can cause side hepatotoxic effects in alcoholic hepatosis.
When conducting long period Therapy at increased dosages should monitor blood test results.
Interaction during complex therapy with other drugs
Simultaneous use with drugs containing ethanol increases the sedative effect of antihistamines, in particular pheniramine. It may also contribute to the occurrence of acute inflammatory processes in the pancreas (pancreatitis).
The simultaneous use of the drug Fervex with morphine derivatives, barbiturates, benzodiazepines, neuroleptics, antidepressants, drugs that exhibit an antihypertensive effect, sedatives, members of the group of n1-blockers increases the sedative effectiveness of these drugs and increases the possibility of developing negative manifestations (urinary retention, feeling of dry mouth cavities, constipation).
It is also necessary to take into account the possibility of the development of manifestations of the central atropine-like type in case of simultaneous use with drugs that have anticholinergic effects, in particular with antihistamines; antidepressant substances included in the imipramine group; neuroleptics belonging to the phenothiazine series; drugs with activity against Parkinson's disease; as well as atropine-like antispasmodics and disopyramide.
In case of complex therapy Fervex drug with drugs that exhibit the properties of activating the oxidation of microsomes, in particular barbiturates, tricyclic antidepressants, drugs that exhibit anticonvulsant effects, as well as rifampicin, ethanol, flumecinol and phenylbutazone, increases the possibility of developing hepatoxic effects.
Concomitant use with glucocorticosteroids increases the likelihood of glaucoma.
Carrying out joint therapy with substances included in the group of salicylates increases the possibility of developing nephrotoxicity.
When used simultaneously with anticoagulant agents, their effectiveness increases.
Joint therapy with drugs that have uricosuric effects reduces their effectiveness.
Use of the product during pregnancy and breastfeeding
Since there is currently no reliable information on the results of clinical trials in pregnant patients, the use of the drug in this group of people is not recommended.
If it is necessary to use Fervex during lactation, it is recommended to interrupt breastfeeding.
Driving vehicles and carrying out high-precision work
During the therapeutic course with Fervex, negative manifestations may develop side effect resulting in dizziness, drowsiness and loss of coordination. It is not recommended to drive technical means and work with high-precision mechanisms throughout the entire therapy.
Interaction with alcohol
Consumption of alcoholic beverages is prohibited during therapy medical device, since this can cause the development of hepatoxicity and other liver pathologies.
Storage
Storage of the drug Fervex must be carried out at a temperature of fifteen to twenty-five degrees. If storage rules are followed, the shelf life is thirty-six months.
Sale in a pharmacy
Buy medical drug Available in online pharmacies without a prescription.
Fervex is a combination drug for symptomatic (aimed at eliminating the symptoms, but not the cause of the disease) treatment of ARVI. The drug contains three active components that determine its pharmacological “policy”. The analgesic-antipyretic paracetamol has an analgesic and antipyretic effect due to its direct effect on the thermoregulatory and nociceptive centers of the hypothalamus. It relieves headaches and musculoskeletal pain, reduces high body temperature. Ascorbic acid (also known as vitamin C) takes part in the management of redox reactions, the synthesis of glucocorticosteroids and collagen, regulates the metabolism of carbohydrates, blood clotting, tissue repair, normalizes the permeability of capillary walls, increases the body’s resistance to viral diseases, which is explained by its beneficial effect on immune system. The histamine H1 receptor blocker pheniramine reduces the secretion of mucus from the nasal cavity, relieves nasal congestion, eliminates sneezing, lacrimation, and eye hyperemia.
ARVIs have quite diverse manifestations of their “pathogenetic” essence: chills, fever, intoxication of the body with waste products of viruses that provoke headaches, difficulty in nasal breathing, rhinorrhea, lacrimation. Thanks to the availability of complex-action drugs, which include components with different mechanisms of action that can eliminate several symptoms that differ from each other at once, adequate therapy becomes possible and accessible. Thus, by using one or two drugs, you can save your energy, time, and, most importantly, money.
One of the leaders among such complex drugs is Fervex. Thanks to its thoughtful composition and carefully calibrated content of each active ingredient, it successfully copes with the symptoms of ARVI without “rewarding” its consumer with a “bouquet” of side effects. For example, instead of the vasoconstrictor phenylephrine, which is often included in anti-cold complexes by manufacturers, Fervex contains pheniramine maleate, which does not provoke unwanted cardiac effects and allows the drug to be taken by people with cardiovascular diseases.
Fervex is available in powder form for the preparation of a solution for oral administration. The drug should be taken 1 sachet 2-3 times a day, optimally in between meals with an interval of at least 4 hours. If the patient has a history of liver or kidney disease, as well as for elderly patients, this interval is extended to 8 hours. The duration of treatment with Fervex without medical advice should be no more than 5 days (if the drug is used as a pain reliever) and no more than 3 days (if the purpose of taking the drug is to reduce body temperature). The solution should be consumed immediately after its preparation (for which, by the way, half a glass of warm water is used).
Some medications, when used together with Fervex, can potentiate the negative side effects of the latter. Among these drugs, mention should be made of some antidepressants, antipsychotic and antiparkinsonian drugs (cause constipation, hyposalivation, urinary retention), glucocorticosteroids (promote the development of glaucoma).
Pharmacology
Combined drug for symptomatic treatment of acute respiratory infections.
Paracetamol is an analgesic-antipyretic, has an analgesic and antipyretic effect, which is associated with its effect on the thermoregulation center in the hypothalamus; eliminates headaches and other types of pain, reduces fever.
Ascorbic acid (vitamin C) is involved in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, in the synthesis of corticosteroids, collagen and procollagen; normalizes capillary permeability. Increases the body's resistance, which is associated with stimulation of the immune system.
Pheniramine is a histamine H1 receptor blocker, reduces rhinorrhea, nasal congestion, sneezing, lacrimation, itching and redness of the eyes.
Pharmacokinetics
Data on the pharmacokinetics of the drug Fervex are not provided.Release form
Powder for preparing a solution for oral administration is lemon-colored, light beige, with a characteristic odor; Brown inclusions are allowed.
Excipients: mannitol, anhydrous citric acid, povidone, anhydrous trimagnesium dicitrate, aspartame, lemon-rum flavor (Antilles).
4.95 g - bags made of combined material (6) - cardboard packs.
4.95 g - bags made of combined material (8) - cardboard packs.
4.95 g - bags made of combined material (12) - cardboard packs.
4.95 g - bags made of combined material (16) - cardboard packs.
Dosage
Fervex is prescribed orally, 1 sachet 2-3 times a day. preferably between meals. The interval between doses of the drug is at least 4 hours.
In patients with impaired liver or kidney function and elderly patients, the interval between doses of the drug should be at least 8 hours.
The duration of treatment (without consulting a doctor) is no more than 5 days when used as an analgesic and no more than 3 days when used as an antipyretic.
The drug should be completely dissolved in a glass of warm water and the resulting solution should be drunk immediately.
Overdose
Symptoms are caused by the action of paracetamol: pale skin, decreased appetite, nausea, vomiting; hepatonecrosis (the severity of necrosis due to intoxication directly depends on the degree of overdose). Toxic effects in adults are possible after taking paracetamol in a dose of more than 10-15 g: increased activity of liver transaminases, increased prothrombin time (12-48 hours after administration); a detailed clinical picture of liver damage appears after 1-6 days. Rarely, fulminant development of liver failure, which may be complicated by renal failure (tubular necrosis).
Treatment: in the first 6 hours after an overdose - gastric lavage, administration of SH-group donors and precursors for the synthesis of glutathione - methionine 8-9 hours after an overdose and N-acetylcysteine after 12 hours. The need for additional therapeutic measures (further administration of methionine, in /in the introduction of N-acetylcysteine) is determined by the concentration of paracetamol in the blood, as well as the time elapsed after its administration.
Interaction
Antidepressants, antiparkinsonian drugs, antipsychotic drugs (phenothiazine derivatives) - increase the risk of side effects (urinary retention, dry mouth, constipation) of Fervex.
When used simultaneously with Fervex, GCS increases the risk of developing glaucoma.
Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which makes it possible to develop severe intoxication with a small overdose of the drug.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic action of paracetamol.
Paracetamol reduces the effectiveness of uricosuric drugs.
Ethanol contributes to the development of acute pancreatitis.
Ethanol enhances the sedative effect of antihistamines.
Side effects
From the digestive system: nausea, pain in the epigastric region; rarely - dry mouth; with long-term use in doses significantly higher than recommended, the likelihood of liver dysfunction increases.
From the hematopoietic system: rarely - anemia, thrombocytopenia, methemoglobinemia.
From the urinary system: rarely - urinary retention; with long-term use in doses significantly higher than recommended, the likelihood of renal dysfunction increases.
Allergic reactions: skin rash, itching, urticaria, Quincke's edema.
Other: rarely - accommodation paresis, drowsiness.
Indications
- ARVI (symptomatic therapy);
- nasopharyngitis.
Contraindications
- erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
- renal failure;
- portal hypertension;
- chronic alcoholism;
- deficiency of glucose-6-phosphate dehydrogenase;
- children under 15 years of age;
- I and III trimesters of pregnancy;
- lactation period (breastfeeding);
- hypersensitivity to the components of the drug.
The drug should be used with caution in case of liver failure, angle-closure glaucoma, hyperplasia prostate gland, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), with viral hepatitis, alcoholic hepatitis, in elderly patients.
Features of application
Use during pregnancy and breastfeeding
The use of the drug is contraindicated in the first and third trimesters of pregnancy and during lactation (breastfeeding).Use for liver dysfunction
In patients with impaired liver function, the interval between doses of the drug should be at least 8 hours.
The drug should be used with caution in case of liver failure, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), viral hepatitis, alcoholic hepatitis.
Use for renal impairment
In patients with impaired renal function, the interval between doses of the drug should be at least 8 hours.Use in children
Contraindication: children under 15 years of age.special instructions
If it is necessary to take metoclopramide, domperidone or cholestyramine while using Fervex, the patient should consult a doctor.
During the use of Fervex, distortion of laboratory test results when quantifying the concentration of uric acid and glucose in plasma is possible.
To avoid toxic liver damage, paracetamol should not be combined with alcohol intake, and should not be taken by persons prone to chronic alcohol consumption.
When using the drug, the risk of developing liver damage increases in patients with alcoholic hepatosis.
With long-term use in doses significantly higher than recommended, monitoring of the peripheral blood picture is necessary.
Use in patients with diabetes mellitus
The drug in the form of a powder for the preparation of a solution for oral administration of lemon does not contain sugar and can be used in patients with diabetes mellitus.
1 sachet of the drug in powder form for the preparation of a solution for oral administration of lemon with sugar or raspberry with sugar contains 11.5 g of sugar, which corresponds to 0.9 XE. This should be taken into account if it is necessary to use this dosage form in patients with diabetes mellitus or in patients on a low-sugar diet.
