Home Coated tongue Human herpes virus type 3. Types of herpes in humans

Coated tongue

Human herpes virus type 3. Types of herpes in humans

Herpes virus 3 strain (varicella zoster) is one of the representatives of the herpesvirus family, which is the causative agent of two diseases: chicken pox and herpes zoster (herpes zoster). Most often, primary infection occurs in childhood, in which case the child suffers the well-known chickenpox.

In the future, the virus may hide in the human body for years, waiting for the right moment to relapse, but in this case the disease will take the form of shingles. This phenomenon is typical for people with a weakened immune system, which is unable to contain the virus and it begins to become more active, affecting the nervous system.

Causes of exacerbation

Herpes 3 strains are extremely contagious, which is why chickenpox is widespread among large groups of children. After the initial exposure to chickenpox, the pathogens remain in the human body for life, hiding in the nerve ganglia.

When a person is exposed to certain factors, he experiences a re-exacerbation of the infection, but under the guise of lichen. Similar factors include everything that affects immunity:

Hypothermia or overheating of the body.
Stressful situations.
Hormonal imbalance.
Neoplasms of various types.
Conditions of immunodeficiency.
Taking certain medications.
Exposure to high doses of ionizing radiation.

Against the background of these factors, a person’s body’s resistance decreases, and the virus, which was previously inactive, begins to manifest itself. The main routes of infection with strain 3 of herpes are: aerogenic, contact and vertical. The source of the virus is a patient whose infection is in the acute stage with a pronounced clinical picture.

Clinical picture

The virus has tropism not only for tissues nervous system, but also to the skin and mucous membranes. This trait is considered the main reason for the appearance of specific symptoms.

Chicken pox

Chickenpox symptoms consist of two characteristic syndromes: damage to the skin and mucous membranes, as well as a manifestation of general intoxication. The disease is acute, starting with hyperthermia and fever. After some time, the first foci of rash appear on the skin: the torso and limbs are affected first, then the head. In severe cases, the lesion also affects the mucous membranes of the mouth. During the process of exacerbation, new elements appear on the patient’s body, creating a polymorphic picture of the disease:

Papules (lumps).
Vesicles (bubbles).
Pustules (pustules).
Erosion (against the background of scratching the above-described elements).
Crusts.

The rash is accompanied by severe itching. There is an increase in the cervical, submandibular, axillary and inguinal lymph nodes.

Intoxication syndrome includes general symptoms:

Weakness and malaise.
Lack of appetite.
Nausea and vomiting.
Blood pressure may decrease.

It has long been known that not only children, but also adults can get chickenpox. IN late age the course of the disease will be more complex:

Fever is more pronounced and lasts longer.
The rash appears later.
High probability of localization of the lesion on the mucous membranes.

Shingles

This disease is characterized by localized damage to an area of the body that is the area where the virus persists. Symptoms appear in those areas of the body whose skin is innervated by the affected nerve ganglia. In most cases, this happens in the area chest(along the intercostal nerves), on the scalp and face. Signs consist of:

Excessive rash on the skin and mucous membranes.
Development of neurological pathologies: neuralgia, neuritis, ganglionitis.
Lymphadenitis.
General intoxication.

The onset of herpes zoster is characterized by the development of severe pain syndrome(neuralgia), which can become painful for the patient. Sensations of burning, tingling, numbness and itching appear in the same area. The pain may intensify after any movement.

Elements of the rash are grouped along the nerve trunks.
After the bubbles appear, the severity of the pain decreases.
Elements of the rash tend to merge, forming large areas of damage.
Over the course of several weeks, fresh lesions appear.
The pathological process is localized only unilaterally.

Lesions of the mucous membranes are similar in appearance to stomatitis, conjunctivitis or keratitis. In some cases, elements of the rash extend beyond the dermatitis and affect adjacent areas of the skin. Episodes of a generalized course of the disease (damage to internal organs) are not excluded, but this is a feature of patients with immunodeficiency.

Treatment

Therapeutic measures aimed at combating herpes type 3 should be as active as possible. Although the disease is incurable, doctors must eliminate symptoms as quickly as possible, prevent complications and prolong the period of remission. Treatment is best carried out in a hospital setting (infectious diseases or neurological department).

The basis of treatment is certain groups of drugs that affect the pathogen and improve the immune system. The choice of medications remains with the doctor, who assesses the severity of each individual case and reviews the medical history of each patient.

The standard list of drugs against herpesvirus includes:

Antiviral (Gerpevir, Zovirax, etc.).
Immunomodulators (Interferon).
NSAIDs (Dicloberl).
Multivitamin complexes.
Antihistamines (Tavegil).
Detoxification therapy.

Local medications must be prescribed. All elements of the rash need to be treated antiseptic solutions(mainly aniline dyes, namely brilliant green). In the presence of stomatitis, the oral cavity is sanitized with a slightly pink solution of potassium permanganate or furatsilin.

Patients diagnosed with chickenpox or herpes zoster are discharged from the hospital only after the crusts have been rejected. All patients who have had complications or often have relapses remain under clinical observation for some time. They are advised to undergo tests for the presence of immunodeficiency.

In order for herpes 3 strains to occur in more mild form and ended without complications, you need to seek help in a timely manner. Only a doctor will conduct a thorough diagnosis, identify the cause, and prescribe suitable treatment.

Herpes is considered the most common disease. Many people have encountered this disease. After the initial infection, any of them is a carrier of the herpes virus, which waits until the immune system will weaken. After treatment, the disease disappears and the virus subsides. How often it manifests itself depends on the person himself.

In medicine, the following types of herpes are distinguished.

Herpes of the first type. One of the varieties of the virus herpes simplex. Characterized by the spread of a rash on the genitals, in oral cavity, on the cervical and facial area, on the visual organ.
Herpes of the second type. Refers to herpes simplex, which is localized in the area of the external genitalia and near the anus.
Herpes of the third type. Refers to one of the manifestations of chickenpox. Often found in children. This disease is considered highly contagious, and the incubation period ranges from five to thirteen days. Rashes appear all over the body.
Herpes of the fourth type. Caused by a virus called Epstein-Barr. This type of disease is extremely rare and leads to the development of mononucleosis and lymphogranulomatosis.
Herpes type five. Caused by a virus called cytomegalovirus. It occurs quite rarely in practice as a result of a strong and prolonged weakening of immune function. The disease is often associated with a sexually transmitted infection. But infection can occur as a result of blood transfusion or through airborne droplets. If the herpes virus type 5 is activated, it will provoke the development of many diseases.
Herpes type six. In practice, it is usually referred to as pseudorubella. Characterized by the spread of the rash throughout the body. Most often manifests itself in infants.
Herpes types seven and eight have not yet been fully studied. It is believed that these diseases are characterized by the sudden onset of a rash, resulting in an effect on the nervous system.

Herpes infection type 1

Herpes type 1 is the most common. The first infection occurs in childhood, and it can manifest itself at the age of three or four years. It is at this time that children are sent to preschool institutions, where the not yet fully formed organism is exposed to various infections. As a result of a nervous shock, the child’s immune system weakens, and the virus begins to actively reproduce and invade nerve cells.

Herpes of the first type often affects the mucous membranes of the genitals, nasal and oral cavities, as well as visual organ. It can occur on the skin of the arms and legs, and also affect the tissues of the nervous system.

The greatest danger to humans is genital herpes type 1. Most often it occurs in women. During pregnancy, the activated virus can cause miscarriage, premature birth, fetal death or lead to fetal deformities.

The main symptoms of type 1 herpes include:

feverish condition;
general weakness;
painful sensations in the head;
pain in muscles and joints;
skin damage;
redness of the affected area;
itching and burning;
the appearance of pimples.

Diagnosis of the disease involves conducting in vitro tests. To do this, the patient’s blood is taken and the presence of immunoglobulins is determined. Using such methods, it is possible to diagnose a previous disease and the presence of immunity to herpes.

The treatment is as follows.

Taking antiviral drugs orally in the form of tablets or injections.
Taking painkillers and antipyretics.
In use local drugs in the form of ointments.
In the use of immunostimulating agents and vitamin complexes.

The duration of the treatment course is from seven to fourteen days. It all depends on when treatment was started and what symptoms accompanied the disease.

Herpes infection type 2

Herpes virus type 2 is a simple type of disease and is similar to herpes type 1. The disease affects the area around the anus and genitals. Genital herpes can affect other parts of the body, and even internal organs. Herpes type 2 is transmitted through sexual contact with a sick person. If women do not pay attention to the first signs in time, the disease will lead to gynecological diseases. In some cases, infertility develops as a result of the disease.

To identify herpes type 2, symptoms appear as a widespread rash in groin area, around the anus and on the genitals. In this case, the rashes can interfere with the patient’s normal life due to chafing of the underwear. Also, upon examination, there is a significant increase in lymph nodes in the groin area. A sharp rise in temperature is possible. Herpes type 2 is considered most contagious when blisters and sores appear on the body. If a person has had type 1 herpes, this does not protect him from genital herpes.

To eliminate herpes simplex virus type 2, it is necessary to carry out complex treatment. It is as follows.

Taking antiviral drugs in tablet form.
In lubricating the affected areas with special ointments that include acyclovir.
Taking vitamin complexes.
Following a special diet.
In refusing sexual activity until complete recovery.
Injected with saline to reduce the concentration of the virus in the blood using injections.

Herpes infection type 3

Herpes type 3 refers to chickenpox or shingles. The disease is highly contagious and is transmitted through airborne droplets or through contact with a sick person. If herpes occurs in children, it manifests itself in the form of chickenpox. If an adult gets herpes of the third type, the disease manifests itself in the form of herpes zoster.

Symptoms in childhood quite clearly expressed. But with treatment, all signs go away and the disease ends happily.

Herpes virus type 3 in childhood leads to the following symptoms.

Severe skin itching.
Increased body temperature.
Extensive rashes on the skin.

Bubbles appear in the places where the nerve trunks are located. After the symptoms disappear, the virus becomes inactive and invades nerve cells.

The main symptoms of herpes zoster in adults include:

severe pain for a week;
increased body temperature;
swelling and redness of the skin;
crust formation after two to three weeks.

Herpes virus type 3 can lead to complications in the form of ganglionitis or ganglioneuritis. These diseases are characterized allergic manifestations, skin ulcers, conjunctivitis and eczema.

The treatment process is carried out in a hospital or at home under the supervision of a doctor.

Herpes infection type 4

In medicine, the virus of this disease is usually called Einstein-Barr. It can lead to infection of the mucous membranes of the mouth and respiratory cavity. Mononucleosis manifests itself with the following symptoms.

Temperature rises to forty degrees.
Pain syndromes.
Feel chronic fatigue and lack of sleep.
Swelling and swelling of the oropharyngeal mucosa.
Plaque formation on the tonsils is grayish in color.
Manifestations of rash on the skin.

Treatment is carried out under the supervision of specialists.

Herpes infection type 5

Herpes type 5 is caused by cytomegalovirus. The disease appears quite rarely. Characterized by the following symptoms.

Increased body temperature.
Fast fatiguability.
No enlarged lymph nodes or plaque on the tonsils.
Damage to internal organs and eyes.

If the disease is observed during pregnancy, the child will be born with various birth defects and infections.

Herpes infection type six

Herpes type six causes a disease in people such as multiple sclerosis. This disease is an autoimmune disease and is characterized by damage to the nervous system and brain. Occurs in patients aged twenty years.

The main symptoms of the disease are considered to be the following.

Fatigue and depression.
Impaired movement coordination.
Change in susceptibility to external factors.

If the disease progresses, the patient's condition worsens.

Manifestations of seizures.
Quick mood changes.
Speech disorders.
Swallowing dysfunction.
No pain response.
Urinary and fecal incontinence.

To protect yourself from this disease, experts recommend testing for type 6 herpes. To do this, they take blood for an ELISA test and determine the presence of antibodies to the virus. This diagnostic method can also be used in newborns. The analysis is carried out on the tenth day after birth.

Taking corticosteroids.
In the use of antiprotectors.
In plasmapheresis with drugs.
Taking immunostimulating drugs.
In the use of drugs that are aimed at producing interferon.

Herpes infection type seven

Herpes type 7 often occurs with herpes type six. This disease leads to cancer.

Characterized by the following symptoms.

Increased weakness.
Fatigue quickly even with little physical exertion.
Depressive state.
Sleep disturbance.
Increase in body temperature to thirty-five degrees. However, it can last for six months.
Enlarged lymph nodes.

Therapeutic measures consist of taking antiviral agents and strengthening immune function.

Herpes infection type eight

Herpes type 8 is very rare. For a long time the disease may not manifest itself in any way. It is transmitted through contact with a sick person, organ transplantation, during pregnancy and birth process from mother to child. Herpes virus type 8 infects lymphocytes.

To determine type eight herpes, the symptoms appear as follows.

Formation of multiple tumors on the skin, mucous membranes, internal organs and lymph nodes.
Manifestations of primary lymphoma.
The occurrence of Castleman's disease.

Treatment of the disease is as follows.

In carrying out surgery.
In use drug therapy. The patient is prescribed interferon, cytostatics, antiviral and antitumor agents.
In use radiation therapy.

Infection with herpes virus type 3 usually occurs in childhood. It causes a disease such as chickenpox. This disease affects a person once in a lifetime, but the virus is integrated into the DNA and remains in it forever. After infection, the affected areas of the skin develop severe itching, body temperature rises; then bubbles filled with liquid contents (vesicles) appear on the skin. The location of the rashes usually coincides with the lines of the nerve trunks; rashes can occupy a significant area of the skin and mucous membranes. The acute phase of the disease lasts from two weeks to a month.

Herpes Zoster, photo

Recurrences of herpes zoster

Significant decrease in immunity caused by taking medicines or exacerbation of chronic diseases, can lead to relapses. During repeated exacerbations, the disease takes the form of herpes zoster.

Shingles most often occurs in people over 50 years of age who suffer from chronic diseases, which provoke a decrease in immunity. Frequent relapses herpes zoster can serve as a kind of indicator indicating low immune status; numerous repeated manifestations of this disease should be a reason to consult a doctor and comprehensively examine the body for the presence of HIV and other infections.

During the course of the disease, various complications may arise: allergies, conjunctivitis, eczematitis, etc. One of the most dangerous complications Shingles is postherpetic neuralgia.

Structure and mechanisms of transmission of herpes virus type 3

In its structure, the third type of herpes virus most closely resembles the widespread herpes simplex viruses - because of this, in some cases, the use of laboratory methods is required for accurate diagnosis. Temperature effects, ultraviolet radiation and some other manifestations external environment can lead to the destruction of the virus. Most often, the herpes zoster virus is transmitted by airborne droplets, less often by contact. Once entering the body, viruses penetrate into the cell through cell membrane; then comes the breeding stage.

Many people experience herpes. This cold sometimes appears on the face or intimate places. A person can carry the virus of this disease for several years and not realize it. It is transmitted through saliva, hygiene items, intimacy or by air.

The disease is divided into 8 types. The most dangerous and difficult to tolerate is herpes type 2, in which blisters, accompanied by itching, appear on intimate parts of the body. Each type of disease has its own characteristic symptoms, they help to qualify herpes and choose the right treatment.

Type I herpes

It occurs most often, manifesting itself in the form of a rash on the mucous membranes of the mouth and nose, as well as on their surfaces. It is acquired in childhood, from six months to two years. In children, herpes appears on the lips and cheeks, and in adults it can affect the area around the eyes and even the genitals. Women this simple type diseases occur more often than half of humanity.

Signs

During the course of the disease, general weakness, fever and joint pain may appear. The affected areas of the skin swell, bubbles with a cloudy liquid appear on them, which quickly increase in size and unite into colonies. With time thin shell The rash becomes a crust and the healing process begins. During the course of the disease, the following may appear:

burning sensation;
discomfort;
headaches and muscle pain;
heat;
chills.

Herpes type 1 during pregnancy is dangerous for the child; it penetrates the placental barrier and can cause fetal deformities, especially in the first trimester.

Type II herpes

It is also called genital, as the disease is localized in the genital area, but can also affect other parts of the body: buttocks and inner thighs. It is usually transmitted through intimate relationship or personal items. Often this simple type becomes ill during puberty, when close relationships with different partners do not always occur with the use of contraceptives.

Girls, unlike boys, statistically suffer from this simple herpes six times more often. In 70% of cases the disease proceeds without visible symptoms and no treatment is required. With this type of disease, rashes appear in several places simultaneously and can recur several times a year.

Signs

They consist of the following manifestations:

swelling;
bubble formation;
enlarged inguinal lymph nodes;
burning;
in men, prostatitis and urethritis are observed;
in women – cervititis and vulvovagnitis. It is noted that the second type of herpes can appear constantly before the first day of menstruation.

Herpes type 2 can impair visual acuity and cause various eye diseases.

Pregnant women have a virus simple type can cause miscarriage and polyhydramnios. And for men it can cause infertility.

III type of herpes

It is transmitted by airborne droplets. First, a spot appears at the site of the lesion, at the second stage it turns into a papule, and then into a vesicle, on which a crust subsequently forms. Unlike simple herpes, it is very dangerous for children, as it can develop into chickenpox.

In adults under 35 years of age, it usually manifests itself on the spinal or cranial nerves, so type 3 herpes usually comes with the prefix – shingles. The rash is usually located on the side of the body or one side of the face. The disease lasts a long time, so it requires a special course of treatment.

Signs

Shingles can affect not only the body, but also the mucous membranes of the eyes. The virus of this type of herpes settles in tissue for life nerve cells. The following symptoms are observed:

an extensive field of single and combined bubbles;
general weakness;
high temperature (after the rash appears it goes away);
burning and itching.

IV type of herpes

This disease immediately manifests itself acutely in the form of tumors on the adrenal glands, kidneys, lymph nodes, ovaries and oral mucous membranes. Once these tumors begin to grow, they infringe on neighboring organs, which leads to pinched nerve endings. Because of this, herpes type 4 can lead to paralysis.

May also provoke Infectious mononucleosis, to which adolescents and children are especially susceptible. Timely detection and treatment of the disease prevents such consequences. Herpes virus type 4 is transmitted through contaminated saliva, personal belongings and household appliances.

Signs

This disease can occur in anyone, but most often it affects children. Its symptoms include:

headache, joint and muscle;
temperature increase;
swelling of the throat mucosa;
rash on skin or mucous membranes, which passes after 3 days without leaving a trace;
gray plaque on the tonsils;
weakness of the body;
increase in the number of lymphocytes in the blood.

This type of virus was discovered by Epstein-Barr, after whom it bears its name.

V type of herpes

This type of disease is very sluggish and mainly affects people suffering from immunodeficiency. In advanced cases, when there is no suitable treatment, herpes type 5 can affect the eyes and internal organs, and also lead to fatal outcome. It is transmitted by contact: through kissing, blood transfusions, and breastfeeding.

Signs

If a person has normal immunity, then cytomegalovirus manifests itself as:

headaches;
temperature;
rapid fatigue;
chills.

And during pregnancy, it is just as dangerous as herpes type 1. This virus can cause a miscarriage or affect the health of the baby after birth, manifesting itself in the form of:

developmental delays;
inflammation in the respiratory and digestive organs;
skin rashes.

VI type of herpes

Most often it affects children under two years of age, and it also occurs in adults and provokes the occurrence of diseases of the neuroinflammatory group in them. IN severe forms As the disease progresses, an organ transplant may be required.

Signs

The first symptom is a sharp rise in temperature, reaching 40 0C, and then small pink bubbles appear and disappear after a few days.

VII type of herpes

It is a continuation of the previous type. Becomes the reason oncological diseases and chronic fatigue. Herpes virus type 7 can live in the human body since childhood, but manifest itself during a period of weakening of the body.

Signs

Unlike simple herpes, this type even affects a person’s intelligence, as well as:

reduces memory;
makes you depressed;
disrupts proper sleep;
leads to chronic pharyngitis.

VIII type of herpes

It can cause Kaposi's sarcoma - malignant tumor. This virus is transmitted to the child from the mother during pregnancy, through direct contact with an infected person, and during organ transplantation. Appears after radiation therapy. Herpes type 8 comes in 4 types:

immunosuppressive;
African;
classical;
AIDS-associated.

Signs

It causes the following symptoms:

burning;
damage to the limbs;
Spots appear first, then they become plaques and subsequently ulcers form from them.

Of all the above types of herpes, the most common are the first and second. By following hygiene rules and limiting contact with people who have obvious signs diseases, you can protect your body from unnecessary viruses.

Varicella zoster virus (herpes virus type 3)

The varicella zoster virus, or type 3 virus, causes two diseases: chickenpox and shingles. Primary infection with this virus usually occurs in childhood and occurs as chickenpox, and relapse as shingles.

Varicella (chickenpox)

Chickenpox most often affects children under 10 years of age.

Transmission of the virus occurs by airborne droplets. The virus penetrates the nasal mucosa into The lymph nodes, then into the blood. With the blood, it enters the skin and mucous membranes, where it begins to actively multiply.

The period from the moment of infection to the appearance of the first symptoms (incubation period) lasts on average from 10 to 21 days. The disease begins with sharp increase temperatures up to 38 degrees. After a few hours it appears on the body spotty rash which spreads to the arms, legs, face and scalp heads. After 5-6 hours, the spotty rash turns into vesicles with transparent contents, which gradually become cloudy. The rash is usually accompanied by severe itching.

After about 2 days, the blisters appear and crusts form in their place, which fall off after 6-8 days, leaving no traces behind.

They are characterized by so-called “sprinkles”, i.e. When the crusts fall off in one place, new rashes form in another.

A person with chickenpox has been contagious to other people since the last 24 hours incubation period- 1-2 days before the appearance of the rash, and on the 5th day from the moment the last vesicle appears. After the illness, lifelong immunity to chickenpox remains, but it does not prevent the activation of the virus in the form of shingles.

Diagnosis of chickenpox

Chickenpox is usually diagnosed based on an external examination of the patient. Women who doubt whether they had chickenpox as a child or not can take a blood test for antibodies to the varicella-zoster virus

Treatment of chickenpox

There is no specific treatment for chickenpox. Doctors recommend bed rest, drinking plenty of fluids, frequent changes of bed and underwear, and daily showers.

At the same time, for prevention infectious complications, it is recommended to treat the skin with antiseptic agents.

Pregnant women who develop chickenpox 5 days before giving birth or 2 days after giving birth are usually given a specific immunoglobulin.

Prevention of chickenpox

Typically, a person with chickenpox is isolated at home. Isolation ends 5 days after the last rash appears.

Currently, a live attenuated vaccine has been developed and used to prevent chickenpox. It is used in children over one year of age and adults.

The vaccine produces immunity in approximately 95% of healthy children. At the same time, immunity to chickenpox lasts about 10 years. It should be borne in mind that this vaccine does not protect against exacerbation of herpes infection in the form of herpes zoster.

In addition, if necessary, within three days from the moment of contact with the infection, a person can be administered specific varicella zoster immunoglobulin, which provides temporary protection.

Shingles

Shingles is viral disease, which occurs due to activation of the virus in people who have previously had chickenpox, and is manifested by pain and skin rashes.

After a person has had chickenpox, the virus does not disappear from the body, but “dormants” in the cells of the nervous system. As long as the immune system works well, the virus does not manifest itself in any way, but if for some reason a person’s immunity decreases, the virus makes itself felt.

Early symptoms of the onset of the disease may be pain, a feeling of numbness or burning, itching, as well as “shooting” pain in a certain area of the body. Then on this area of skin appear pink spots, which gradually turn into painful and itchy blisters. Most often, the rashes are located in the chest, ribs, along the intercostal nerves, and, as a rule, on one side. In severe cases, the virus can affect the eyes, ears, meninges, brain.

Over the course of a week, the number of bubbles increases, and the liquid contained in them becomes cloudy. Then the bubbles gradually dry out, becoming covered with a crust on top. When the crust falls off, a lighter area of skin or scar remains in this place. All rashes disappear within 2-4 weeks, but pain along the nerves may remain for quite a long time (“postherpetic neuralgia”).

Shingles is contagious to others. The virus is found in large quantities in the fluid contained in the blisters. It is most dangerous for people, especially children, who have not yet had chickenpox. When such people come into contact with a sick person, they may develop typical chickenpox. Therefore, during the period when a patient develops rashes, it is advisable to isolate small children and people who have not had chickenpox from the patient.

Diagnosis of herpes zoster

Shingles is usually diagnosed based on the manifestations of the disease. In severe cases, the pathogen is isolated in cell cultures.

Other research methods are used if there is damage to the eyes, ears, or central nervous system.

Treatment of herpes zoster

Used to treat shingles antiviral drugs. The choice of drug, treatment regimen and dosage is made by the attending physician based on the form of the disease and the patient’s condition.

If the patient is worried severe pain, the doctor may prescribe painkillers and sedatives. For postherpetic neuralgia, physiotherapy is additionally used.

It is also important to know that if you have shingles, you should not be exposed to ultraviolet radiation, as ultraviolet rays enhance the multiplication of the virus and worsen the course of the disease.