Xylometazoline eye drops. Instructions for use of xylometazoline spray and nasal drops for children and adults

Currently, there are a large number of drugs for the common cold. Among them, Xylometazoline deserves special attention, since it has a pronounced effect, however, as with other medications, you need to study the instructions for use before use. It is also important to first consult with your doctor.

The medication is available in the form of a spray and nasal drops. Let's look at the main components that are included:

1. Xylometazoline hydrochloride (0.5 milligrams).
2. Benzalkonium chloride (0.15 milligrams).
3. Disodium edetate (0.47 milligrams).
4. Potassium dihydrogen phosphate (3.63 milligrams).
5. Sodium dihydrogen phosphate dihydrate (3.54 milligrams).
6. Sodium chloride (9 milligrams).

Also in the composition, along with xylometazoline, there is purified water. The spray is available in bottles with dispensers of 10 and 20 milliliters.

The drug may cause human body side effects, which is why, before use, consultation with a specialist is required.

pharmachologic effect

This medication has a vasoconstrictor effect. Due to the narrowing of large and small vessels, swelling and hyperemia are reduced. If the drug is used for rhinitis, nasal breathing improves significantly.

Indications for use

• Availability acute form allergic rhinitis;
• otitis media;
• hay fever and sinusitis.

Also appointed medicinal composition in case of preparing the patient for certain diagnostic procedures carried out with the nasal sinuses.

For normal nasal congestion, this composition is not prescribed, as other medications are used.

Contraindications and side effects

• angle-closure glaucoma;
• pronounced atherosclerosis;
• were surgical interventions in brain tissue;
• present increased sensitivity to components;
• there is an individual intolerance to the drug;
• the presence of tachycardia and arterial hypertension.

When treated with this medication side effects rarely appear. Among them, swelling of the mucous membrane, increased blood pressure, irregular heartbeat, headaches, dizziness, and allergic reactions, itching, fever, rash.

When manifested side effects You must immediately stop using the medication and consult a specialist.

Instructions for use

Instructions for using nasal drops contain the following recommendations:

• carry out therapy for 7-14 days;
• the dose is prescribed by a doctor, depending on age;
• for children aged two to seven years, a gel is prescribed;
• Children during treatment should be observed by a doctor.

When manifested colds If crusts form in the sinuses, you should use a medicinal composition in the form of a gel.

Xylometazoline during pregnancy

During pregnancy, as well as during breastfeeding, requires direct supervision by a physician. The dosage, as well as the frequency of use of the medicine, are prescribed by a specialist. During these periods, the effect of the drug is taken into account, as well as the risk of harm to the woman and her child.

To avoid complications during pregnancy, it is recommended to replace Xylometazoline with safer drugs.

Overdose

Currently, no cases of drug overdose have been identified. To avoid harm to the body, it is not recommended to take medicinal product long time(longer period than the therapeutic course).

Drug interactions

Terms of sale

The medicine is in free sale. It can be found at any pharmacy, and no prescription is required to purchase it.

Storage conditions and periods

The medicinal composition must be stored under the following conditions:

• at a temperature not exceeding 25 degrees;
• where there is no natural light;
• no access for children.

The medication can be stored for three years, after which you should get rid of it and purchase a new spray.

Analogues

If necessary, Xylometazoline can be replaced with the following drugs:

1. Eucabalus.
2. Tizin.
3. Rinoxyl.
4. Xylomethazole.
5. Xinos.

Before choosing a replacement drug on your own, you need to get a recommendation from a specialist.

Xylometazoline - medicine, part of the group of vasoconstrictor drugs, intended for use in ENT practice.

What is the composition and release form of the drug Xylometazoline?

The active ingredient of the drug is xylometazoline hydrochloride, the amount of which is 500 micrograms or 1 milligram. Auxiliary components of the product: sodium hydrogen phosphate, disodium edetate, benzalkonium chloride, potassium dihydrogen phosphate, sodium chloride and water for injection.

The drug Xylometazoline is available in the form clear solution for instillation into the nose with a concentration of the active substance of 0.05 and 0.1 milligrams. A slightly yellowish tint is acceptable. Supplied in plastic bottles of 25, 15, 10 milliliters, equipped with a dispenser nozzle. Included in the list of medications that can be purchased without a prescription.

What is the effect of Xylometazoline?

Xylometazoline is one of the alpha-adrenergic agonists; it has a vasoconstrictor effect. It is used only in otorhinolaryngological practice, since it can effectively eliminate manifestations of rhinitis, and also restores nasal breathing.

Xylometazoline, acting on receptors specific to it, leads to an increase in the tone of smooth muscle fibers located in the wall of the vessels of the nasal mucosa. This circumstance leads to a reduction in swelling and release of the upper respiratory tract, which helps to alleviate the patient’s condition.

In addition, local use of the drug helps to suppress the secretory activity of the epithelium of the nasal cavity, and this leads to a decrease in the amount of mucus secreted, which additionally helps to free up nasal breathing.

The effect of the drug Xylometazoline begins a few minutes after use. Duration therapeutic effect does not exceed several hours.

Despite the ambiguous attitude towards vasoconstrictor drugs, the use of such drugs is still recommended by most specialists. Prolonged nasal congestion can result in complications of the disease in the form of sinusitis and so on.

It is important to note that the use of vasoconstrictor drugs should be strictly limited in time. With prolonged and uncontrolled use, the likelihood of developing atrophic rhinitis sharply increases.

Coefficient systemic action extremely small. When used within recommended dosages, the presence of xylometazoline in blood plasma is almost impossible to determine. Because of this, systemic side effects are very rare.

What are the indications for use of the drug Xylometazoline?

The use of the vasoconstrictor Xylometazoline is indicated in the presence of the following conditions:

Infectious rhinitis;
Allergic rhinitis;
Sinusitis;
Otitis media

In addition, the drug is used for hay fever.

What are the contraindications for use of Xylometazoline?

The instructions for use prohibit the use of the drug Xylometazoline in the presence of the conditions listed below:

Individual intolerance;
Arterial hypertension;
Glaucoma;
Severe atherosclerosis;
Thyrotoxicosis;
Surgeries on the meninges in the recent past;
Age less than 6 years;
The need for the use of tricyclic antidepressants and MAO inhibitors.

Relative contraindications: angina pectoris, prostate adenoma, diabetes, pregnancy and lactation.

What are the uses and dosage of Xylometazoline?

The duration of use should not exceed 5-7 days. If treatment is ineffective, it is very important to visit a specialist and prescribe complex therapy, including medication and physiotherapeutic treatment.

Overdose from Xylometazoline

Symptoms of overdose are as follows: dryness and burning in the nose, tachycardia, increased blood pressure, and headache. Treatment: withdrawal of xylometazoline, symptomatic treatment.

What are the side effects of Xylometazoline?

With prolonged and uncontrolled use of the drug, the following negative consequences may develop: dryness of the nasal mucosa, disorders heart rate, insomnia, visual disturbances, depression, increased swelling of the mucous lining of the nasal cavity, as well as increased blood pressure, in addition, paresthesia in the extremities.

special instructions

It is very important to clean the nasal passages before using the drug. Otherwise, the effectiveness of the medicine may be significantly reduced. For chronic rhinitis, the use of the medication is not recommended.

How to replace Xylometazoline, what analogues should I use?

Xylometazoline-Rusfar, For the nose, Sanorin-Xylo, Nosolin balm, Grippostad Rino, Rinorus, Influrin, Rinonorm, Otrivin, Olint, Rinotaiss, Xylene, Xylometazoline bufus, Tizin xylo, Xylometazolin-Betalek, Xymelin Eco, Xylobene, Xymelin, Snoop, Nazolin, Espazolin, Rinomaris, Rinostop, Galazolin, Nosolin, Nosolin-balsam, Dlynos, Xylometazoline hydrochloride, Brizolin, as well as Farmazolin, Suprima-NOZ are analogues.

Conclusion

The duration of treatment, as well as the dosage, should be strictly limited. It is strictly unacceptable to use the drug for more than a week.

The patient must independently study the instructions for use of the prescribed drug. Be healthy!

Xylometazoline is a vasoconstrictor intended for topical use for ENT diseases.

Release form and composition

The drug is available in the form of 0.05% and 0.1% nasal drops, 0.05% and 0.1% eucalyptus nasal spray.

The drops are a clear, colorless or yellowish solution, 1 ml of which contains:

• Auxiliary components such as: sodium hydrogen phosphate, disodium edetate, sodium chloride, potassium dihydrogen phosphate, benzalkonium chloride, purified water.

Drops are sold in polymer bottles of 10, 15 and 25 ml with and without a dispenser.

The spray is a colorless or slightly colored liquid with a characteristic eucalyptus odor, 1 ml of which contains:

• 500 mcg or 1 mg xylometazoline hydrochloride;
• Such auxiliary components as: sodium hydrogen phosphate dodecahydrate, disodium edetate dihydrate, benzalkonium chloride, potassium dihydrogen phosphate, sorbitol, macrogol glyceryl hydroxystearate, sodium chloride, glycerol, Eucalyptus oil, purified water.

The spray is sold in bottles with a spray nozzle of 10 and 20 ml.

Indications for use of Xylometazoline

As stated in the instructions for Xylometazoline, this decongestant is intended for short-term symptomatic treatment:

• Acute allergic rhinitis;
• Sinusitis;
• acute respiratory infections with symptoms of rhinitis;
• Hay fever;
• Otitis media (as an adjuvant to relieve swelling of the nasal mucosa).

In addition, Xylometazoline, according to the instructions, is prescribed to patients in preparation for diagnostic manipulations and procedures in the nasal passages.

Contraindications

According to the annotation for this medication, the use of Xylometazoline is contraindicated:

• Patients with glaucoma;
• With severe atherosclerosis;
• For angle-closure glaucoma;
• With tachycardia;
• With atrophic rhinitis;
• With thyrotoxicosis;
• Patients who have undergone surgery meninges;
• Children under 6 years old in the form of a 0.1% solution;
• If you have hypersensitivity to xylometazoline hydrochloride or any auxiliary component.

Xylometazoline is prescribed, but according to strict indications and under the constant supervision of a doctor:

• Pregnant women;
• For angina pectoris;
• For patients with hyperplasia prostate gland;
• Children under 2 years old in the form of a 0.05% solution;
• During lactation;
• Patients with diabetes mellitus.

Directions for use and dosage of Xylometazoline

Nasal drops in a concentration of 0.1% are prescribed to children from 6 years of age and adults 2-3 drops. in each nasal passage three times a day. Children under 6 years of age can only use a 0.05% solution. It is prescribed 1-2 drops in each nasal passage twice a day.

Nasal spray in a concentration of 0.1% is prescribed to adults and children over 6 years of age, one injection into each nasal passage 2-3 times a day. Children 2-6 years old - 0.05% spray, one injection 1-2 times a day.

Like any vasoconstrictor, Xylometazoline is not recommended for use for more than 7 days in a row, because it can be addictive. If no improvement is observed during this time, you should consult a doctor to clarify the diagnosis and prescribe appropriate treatment.

Side effects of Xylometazoline

Numerous reviews from patients who were treated with Xylometazoline indicate that this drug is well tolerated and does not have side effects if the dosage regimen recommended by the doctor is followed.

However, it should be noted that in individual cases the following are possible: increased blood pressure, disturbances in heart rhythm, vision, sleep disturbance, headache, vomiting.

With prolonged and/or frequent use of Xylometazoline, burning, hypersecretion, irritation, tingling and dryness of the nasal mucosa are possible, as well as depressive state. It is also worth noting that the latter phenomenon occurs in extremely rare cases if the patient uses the drug in high doses for long period.

An overdose of a drug is fraught with the appearance of side effects or intensification of existing ones.

If the drug is accidentally taken orally (more often in children), the following may occur: arrhythmia, tachycardia, confusion, increased blood pressure, decreased body temperature, shock-like hypotension, bradycardia, drowsiness, apnea and coma. Therefore, in this case, you should immediately call an ambulance.

special instructions

For a long period, for example, with chronic rhinitis, the use of any vasoconstrictor is not recommended, as there is a risk of developing addiction to the medication, reducing the sensitivity of blood vessels to the active substance, or secondary vasodilation, which provokes swelling of the nasal mucosa.

Before using Xylometazoline, you should clear the nasal passages of crusts and mucus, this will allow the drug to act on the mucous membrane, thereby improving the therapeutic effect.

Xylometazoline hydrochloride is pharmaceutically incompatible with tricyclic antidepressants and MAO inhibitors. And when used together with non-selective monoamine reuptake inhibitors, hypertension may develop.

Xylometazoline analogues

The pharmaceutical industry offers for sale many analogs of Xylometazoline, in particular: Galazolin, Dlynos, Influrin, Xylen, Xymelin, Nosolin, Rinonorm, Otrivin, Rinostop, Farmazolin, Tizin, Sanorin, Sialor, Espazolin.

Terms and conditions of storage

Xylometazoline is an over-the-counter drug. Its shelf life is 3 years, subject to the storage rules recommended by the manufacturer - protected from contact sun rays, a dry and cool place where the air temperature does not exceed 15 ºС. After opening the package, the drops must be used within 28 days.

Xylometazoline hydrochloride is the active ingredient in many intranasal solutions under various trade names: Galazolin, Xylene, Otrivin, Snoop, Tizin and others.

Compound

Xylometazoline intranasal solution contains the following components:

• basic active substance– xylometazoline hydrochloride;
• auxiliary components - benzalkonium chloride (0.15 mg), sodium chloride (9.0 mg), potassium dihydrogen phosphate (3.63 mg), sodium edetate (0.5 ml), purified water.

Release form

Xylometazoline nasal drops are available in the form of a clear, colorless or pale yellow, odorless solution with a bitter aftertaste.

In pharmacies you can find three types of medicine:

• Spray Xylometazoline . The liquid is packaged in bottles equipped with a dispenser and a protective cap. Active substance concentration – 0.1%
• Xylometazoline nasal drops . The intranasal solution is sold in small polymer bottles, the concentration of xylometazoline hydrochloride is 0.1%. Used to treat nasal congestion in adults and children over 6 years of age.
• Xylometazoline nasal drops for children . The reduced content of the main component by half (0.05%) allows the medication to be used safely in infants.

All of the listed drugs with xylometazoline hydrochloride are available in plastic vials of three sizes: 10 ml, 15 ml and 25 ml. Each bottle is packaged in cardboard box and includes instructions for use.

Indications and contraindications

• in acute form;
• ARVI with symptoms;
• maxillary;
• (to eliminate swelling in the nasopharynx).

Xylometazoline is allowed to be used to eliminate listed signs in children, the concentration of the solution should be 0.05%.

Contraindications to the use of the drug:

• individual intolerance to the components of the drug;
• arterial hypertension;
• glaucoma;
• previously held surgery on the membranes of the brain;
• atrophic rhinitis;
• xylometazoline is not recommended for use during pregnancy and lactation, and the drug should not be used at a concentration of 0.1% in children under 6 years of age.

Xylometazoline should not be used for eye drops to avoid the development of inflammatory and allergic reactions.

If you are individually intolerant to the substance, please inform your doctor so that he can select nasal drops without xylometazoline for you.

Harm and benefits of xylometazoline

The positive effect of using the drug is clearly pronounced, however, abuse of Xylometazoline intranasal solution can lead to negative consequences and cause addiction .

It develops due to the frequent use of a spray to irrigate the nasal mucosa and eliminate the symptoms of breathing problems. Atrophy of the glands that produce mucus occurs, which causes dryness and burning in the nose. Therefore, in some cases it is worth opting for drops without xylometazoline.

It is better not to treat with Xylometazoline during pregnancy, since this drug has not been tested on pregnant women. Therefore, possible side effects affecting fetal development have not been thoroughly studied.

Instructions and dosage

Before you start using Xylometazoline spray, you should read the instructions for use to avoid negative consequences.

• adults and children over 6 years old - 2-3 injections of a solution at a concentration of 0.1% into each nasal passage up to 4 times a day;
• children aged 1 month to 5 years - no more than 2 drops of the drug at a concentration of 0.05% in each turn, no more than 2 times a day.

Xylometazoline should be used with caution during pregnancy and breastfeeding, taking into account Negative consequences that may occur in a child. Treatment with the drug is permissible if the benefit to the mother outweighs the potential risk to the fetus.

Instructions for use of Xylometazoline:

1. Clear your nose of mucus as much as possible.
2. Press one nostril with your fingertip and insert the tip of the medicine bottle into the other.
3. Press the dispenser 1-2 times when using the spray or irrigate the mucous membrane with 2-3 drops of the product while inhaling.
4. Repeat the procedure for the second nostril.

Overdose

If an overdose occurs while using Xylometazoline, you should immediately discontinue treatment with this drug. medication and consult a doctor to choose the appropriate medication.

Side effects of xylometazoline

If the permissible concentration of the substance and the frequency of use are exceeded, treatment with Xylometazoline may be harmful.

Abuse of the drug threatens:

• hyperfunction of the mucous glands of the nasal cavity;
• the occurrence of tingling, burning and dryness of the epithelium;
• irritation of the membranes of the nasopharynx;
• sneezing;
• numbness of the soft tissues of the nose and throat.

In rare cases, patients using Xylometazoline complain of:

• tachycardia;
• sleep disturbance;
• dyspeptic disorders;
• arterial hypertension;
• headache;
• visual impairment.

Analogues

Xylometazoline has both complete analogues, and medications that have a similar therapeutic effect.

The following drugs, which contain the same active substance, can be considered substitutes and synonyms for Xylometazoline:

• Galazolin.
• Rinostop,
• For the nose,
• Otrivin.

Other medications are also used to relieve nasal congestion. Patients often have a question about what is better to use - Oxymetazoline or Xylometazoline. Both drugs have a similar chemical structure and belong to a group of drugs that bind to alpha-1 and alpha-2 adrenergic receptors in the mucous membrane of the nasal passages.

Let's look at the difference between Xylometazoline and Oxymetazoline:

• Breathing relief during treatment with Xylometazoline lasts 8 or 9 hours; when irrigating the nasal passages with Oxymetazoline, the effect lasts up to half a day.
• Differences in the severity of withdrawal symptoms. When stopping treatment with Xylometazoline, the risk of deterioration of the condition is high, in contrast to the situation with the withdrawal of Oxymetazoline.
• The difference between Xylometazoline and Oxymetazoline is also that the first cannot be used by pregnant women or women who are breastfeeding, while the second can be used during these periods, but in a small dosage and under the supervision of a doctor.

Before starting treatment with xylometazoline-based drugs, you should consult your doctor. If used uncontrolled, even cold remedies can cause harm to the body.

Useful video about the use of vasoconstrictor drugs

INSTRUCTIONS
By medical use drug

Registration number:

LSR-003901/07 - 190115

Trade name of the drug:

Xylometazoline

International nonproprietary name:

xylometazoline.

Dosage form:

nasal drops.

Compound

Composition per 1 ml
Active substance:
xylometazoline hydrochloride - 0.5 mg and 1 mg
Excipients:
sea ​​water- 400 mg
potassium dihydrogen phosphate -0.45 mg
purified water - up to 1 ml

Description

Colorless or slightly colored transparent liquid.

Pharmacotherapeutic group:

anticongestive agent - vasoconstrictor (alpha adrenergic agonist)

CodeATX R01AA07

Pharmacological properties

Pharmacodynamics

Xylometazoline belongs to the group of local vasoconstrictors (decongestants) with an alpha-adrenomimetic effect, causing constriction blood vessels mucous membrane of the nasal cavity, eliminating swelling and hyperemia. Facilitates nasal breathing during rhinitis.
The effect of the drug begins a few minutes after its use and lasts for 12 hours.

Sea water, which is part of the drug as an auxiliary component, helps maintain normal physiological state mucous membrane of the nasal cavity, which helps reduce the symptoms of irritation and dryness that occur with long-term use of xylometazoline.

Pharmacokinetics

At local application xylometazoline is practically not absorbed; plasma concentrations are so low that they cannot be determined by modern analytical methods.

Indications for use

• Acute respiratory diseases (ARI) with symptoms of rhinitis (runny nose);
• Acute allergic rhinitis;
• Sinusitis;
• Hay fever;
• Otitis media (to reduce swelling of the nasopharyngeal mucosa);
• Preparing the patient for diagnostic manipulations in the nasal passages.

Contraindications

Hypersensitivity, arterial hypertension, tachycardia, severe atherosclerosis, glaucoma, atrophic rhinitis, thyrotoxicosis, surgical interventions on the meninges (history), childhood(up to 6 years - for 0.1% solution).
Do not use during therapy with monoamine oxidase inhibitors and tricyclic antidepressants.

Carefully

Pregnancy, lactation period, ischemic disease heart disease (angina), prostatic hyperplasia, diabetes mellitus; children under 2 years of age (for 0.05% solution).

Use during pregnancy and breastfeeding

If it is necessary to use the drug during pregnancy and lactation, you should consult your doctor to assess the balance of benefits for the mother and the potential risk for the fetus/infant.

Directions for use and doses

Intranasally.
Drops 0.05%: infants and children under 6 years of age - 1-2 drops in each nasal passage 1-2 times a day (no more than 3 times a day), children over 6 years of age - 2-3 drops in each nasal passage 3-4 times a day.
Drops 0.1%: adults and children over 6 years old - 2-3 drops in each nasal passage up to 4 times a day.

Side effects

With frequent and/or prolonged use - irritation and/or dryness of the nasopharyngeal mucosa, burning, tingling, sneezing, hypersecretion. Rarely - swelling of the nasal mucosa, palpitations, tachycardia, arrhythmias, increased blood pressure, headache, vomiting, insomnia, blurred vision; depression (with long-term use of high doses).

Overdose

Symptoms: increased side effects.
Treatment: symptomatic.

Interaction with other drugs

Incompatible with monoamine oxidase inhibitors (MAO) and tricyclic antidepressants.

special instructions

Before use, it is necessary to clean the nasal passages.
Do not exceed recommended doses, especially in children and the elderly

Should not be used for more than 7 days, unless the doctor recommends a different duration of treatment. If symptoms persist after this time, you should consult a doctor.

Effect on ability to drive vehicles, mechanisms

Release form

Nasal drops 0.05%.
1 ml, 2 ml in a polymer dropper tube with a valve. Labels are placed on the dropper tube. 1, 5, 10 dropper tubes with instructions for use are placed in a cardboard pack.
10 ml, 15 ml in dark glass bottles with a screw neck, sealed with caps with pipettes. Labels are attached to the bottles. Each bottle with instructions for use is placed in a cardboard pack.

Nasal drops 0.1%.
2 ml in a polymer dropper tube with a valve. Labels are placed on the dropper tube. 5 dropper tubes with instructions for use are placed in a cardboard pack.

Storage conditions:

In a dry place, protected from light, at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Best before date:

2 years. Do not use after expiration date.

Conditions for dispensing from pharmacies:

Over the counter.

MANUFACTURER/ORGANIZATION ACCEPTING CLAIMS

CJSC "Proizvodstvennaya" pharmaceutical company Update",
Novosibirsk region, r.p. Suzun, st. K. Zyatkova, 18.
630071, Novosibirsk, st. Stationnaya, 80.