NSAIDs. It is a derivative of phenylpropionic acid.
Drug: NUROFEN®
Active substance of the drug:
ibuprofen
ATX coding: M01AE01
CFG: NSAIDs
Registration number: P No. 013012/01
Registration date: 12/29/06
Owner reg. credential: RECKITT BENCKISER HEALTHCARE INTERNATIONAL Ltd. (Great Britain)
Nurofen release form, drug packaging and composition.
White or almost white film-coated tablets white, round, biconvex, with the inscription “Nurofen” in black on one side.
1 tab.
ibuprofen
200 mg
Excipients: croscarmellose sodium, sodium lauryl sulfate, sodium citrate, stearic acid, colloidal silicon dioxide, carmellose sodium, talc, acacia gum, sucrose, titanium dioxide, macrogol 6000, opacode (shellac, black iron oxide, n-butyl alcohol, soy lecithin , denatured alcohol, anti-foam component DC 1510).
6 pcs. - blisters (1) - cardboard packs.
6 pcs. - blisters (2) - cardboard packs.
12 pcs. - blisters (1) - cardboard packs.
12 pcs. - blisters (1) - plastic containers.
12 pcs. - blisters (2) - cardboard packs.
12 pcs. - blisters (3) - cardboard packs.
12 pcs. - blisters (8) - cardboard packs.
Effervescent tablets are white, round, flat, with a rough surface; the resulting solution is transparent, colorless, opalescent.
1 tab.
ibuprofen sodium dihydrate
256 mg,
which corresponds to the content of ibuprofen
200 mg
Excipients: potassium carbonate, lemon acid anhydrous, sorbitol, sodium saccharin, sucrose monopalmitate.
10 pieces. — polypropylene tubes (1) — cardboard packs.
The description of the drug is based on the officially approved instructions for use.
Pharmacological action of Nurofen
NSAIDs. It is a derivative of phenylpropionic acid. It has analgesic, antipyretic and anti-inflammatory effects. The effect of the drug is due to inhibition of prostaglandin synthesis by blocking the enzyme cyclooxygenase.
Pharmacokinetics of the drug.
Suction and distribution
After oral administration, ibuprofen is rapidly absorbed from the gastrointestinal tract. Plasma protein binding is 90%. Slowly penetrates into the joint cavity, lingers in the synovial tissue, creating higher concentrations in it than in plasma.
Metabolism
Biotransformed in the liver. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form.
Removal
Ibuprofen is excreted in the urine unchanged (no more than 1%) and in the form of conjugates, a small part is excreted in the bile. T1/2 is about 2 hours.
Indications for use:
Headache;
Migraine;
Toothache;
Neuralgia;
Myalgia;
Back pain;
Rheumatic pains;
Algodismenorrhea;
Fever due to influenza and ARVI.
Dosage and method of administration of the drug.
For adults and children over 12 years of age, the initial dose of the drug is 200 mg 3-4 times a day. To achieve a rapid clinical effect, it is possible to increase the initial dose to 400 mg 3 times a day. Maximum daily dose- 1200 mg.
Children aged 6 to 12 years - 200 mg no more than 4 times a day. It should be taken into account that the drug can only be prescribed to children weighing more than 20 kg. The interval between taking tablets should be at least 6 hours.
Do not take more than 6 tablets. per 24 hours. Maximum dose - 1.2 g.
Film-coated tablets should be taken with water. Effervescent tablets should be dissolved in 200 ml of water (1 glass).
Side effects of Nurofen:
When using Nurofen for 2-3 days side effects are practically not observed. In case of long-term use, the following side effects may occur.
From the outside digestive system: nausea, vomiting, heartburn, anorexia, discomfort in the epigastrium, diarrhea, flatulence, erosive and ulcerative lesions of the gastrointestinal tract (in some cases complicated by perforation and bleeding), abdominal pain, irritation, dryness and pain in the oral mucosa, ulceration of the gums , aphthous stomatitis, pancreatitis, constipation, hepatitis.
From the side of the central nervous system: possible headache, dizziness, insomnia, agitation, drowsiness, depression, confusion, hallucinations; rarely - aseptic meningitis (more often in patients with autoimmune diseases).
From the sensory organs: reversible toxic neuritis optic nerve, blurred vision, diplopia, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic origin, scotoma); hearing loss, ringing or noise in the ears.
From the outside of cardio-vascular system: heart failure, increased blood pressure, tachycardia.
From the urinary system: nephrotic syndrome, spicy renal failure, nephritis, polyuria, cystitis.
From the hematopoietic system: anemia (including hemolytic, aplastic), thrombocytopenia, thrombocytopenic purpura, agranulocytosis, leukopenia.
Allergic reactions: skin rash, itching, urticaria, angioedema, anaphylactoid reactions, anaphylactic shock, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), eosinophilia, allergic rhinitis.
From the respiratory system: bronchospasm, shortness of breath.
Other: increased sweating.
With long-term use in high doses: ulceration of the gastrointestinal mucosa, bleeding (including from the gastrointestinal tract, gums, uterine, hemorrhoidal), visual impairment (impaired color vision, scotoma, amblyopia).
Contraindications to the drug:
Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, incl. peptic ulcer and duodenum, ulcerative colitis, peptic ulcer, Crohn's disease;
Severe heart failure;
Severe course arterial hypertension;
- “aspirin” bronchial asthma, urticaria, rhinitis, provoked by taking acetylsalicylic acid(salicylates) or other NSAIDs;
Diseases of the optic nerve, impaired color vision, amblyopia, scotoma;
Glucose-6-phosphate dehydrogenase deficiency;
Hemophilia, hypocoagulable states;
Leukopenia;
Hemorrhagic diathesis;
Severe liver and/or kidney dysfunction;
Hearing loss, pathology of the vestibular apparatus;
III trimester of pregnancy;
Lactation (breastfeeding);
Children under 6 years of age;
Hypersensitivity to ibuprofen or to the components of the drug.
Prescribe with caution if there is a history of gastric and duodenal ulcers, gastritis, enteritis, colitis, bleeding from the gastrointestinal tract, concomitant diseases liver and/or kidneys (including cirrhosis of the liver with portal hypertension, nephrotic syndrome), chronic heart failure, arterial hypertension, blood diseases unknown etiology, bronchial asthma, autoimmune diseases(including systemic lupus erythematosus), hyperbilirubinemia, pregnancy (I and II trimesters), during lactation, children under 12 years of age.
Use during pregnancy and lactation.
Nurofen is contraindicated for use in the third trimester of pregnancy.
The use of the drug in the first and second trimesters of pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus or infant.
If it is necessary to prescribe the drug during lactation, the issue of stopping breastfeeding should be decided.
Special instructions for use of Nurofen.
If side effects occur, you should stop taking the drug and consult a doctor.
If symptoms persist after taking the drug for 2-3 days, the drug should be discontinued and the diagnosis clarified.
If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.
When taking effervescent tablets, patients on a hypopotassium diet should take into account that 1 tablet contains 1530 mg of potassium carbonate; sick diabetes mellitus should take into account that 1 tablet contains 40 mg of sodium saccharinate; Patients with fructose intolerance should take into account that 1 tablet contains about 376 mg of sorbitol.
Control of laboratory parameters
During long-term use of the drug, it is necessary to monitor the peripheral blood picture and functional state liver and kidneys. If symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, general analysis blood (hemoglobin determination), stool test for occult blood.
Impact on the ability to drive vehicles and operate machinery
Patients should refrain from all activities that require increased attention and speed of psychomotor reactions.
Drug overdose:
Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, decreased blood pressure, bradycardia, tachycardia, atrial fibrillation, respiratory arrest.
Treatment: gastric lavage (only within 1 hour after administration), taking activated carbon, alkaline drinking, forced diuresis, symptomatic therapy.
Interaction of Nurofen with other drugs.
When administered simultaneously, ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (an increase in the incidence of acute coronary insufficiency may occur after starting ibuprofen in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent).
When used simultaneously with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding increases.
When used together with ibuprofen, cefamandole, cefoperazone, cefotetan, valproic acid, and plicamycin increase the incidence of hypoprothrombinemia.
When used together, cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which leads to an increased nephrotoxic effect.
Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects.
Drugs that block tubular secretion, when used simultaneously, reduce the excretion and increase the plasma concentration of ibuprofen.
When used together, inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions.
Inhibitors of microsomal oxidation reduce the risk of developing hepatotoxic effects of ibuprofen.
When used together, ibuprofen reduces the hypotensive activity of vasodilators, the natriuretic effect of furosemide and hydrochlorothiazide.
Ibuprofen reduces the effectiveness of uricosuric drugs and enhances the effect of indirect anticoagulants, antiplatelet agents and fibrinolytics.
Increases the side effects of mineralocorticoids, corticosteroids, estrogens, ethanol.
When used together, it increases the hypoglycemic effect of oral antidiabetic agents (sulfonylurea derivatives) and insulin.
When taken simultaneously, antacids and cholestyramine reduce the absorption of ibuprofen.
When used together, ibuprofen increases the blood concentration of digoxin, lithium, and methotrexate.
Caffeine enhances the analgesic effect of ibuprofen.
Terms of sale in pharmacies.
The drug is approved for use as a means of OTC.
Terms of storage conditions for the drug Nurofen.
The drug should be stored in a dry place, out of reach of children, at a temperature not exceeding 25°C. Shelf life: 3 years.
We are all familiar with the feeling of extreme discomfort that pain brings with it. Pain prevents you from sleeping peacefully and interferes with your work and decision-making. Usually, to alleviate the condition, we take any painkiller that is at hand, after which we quickly forget about the recent suffering, continue to live our normal lives, including meeting with friends and partners and drinking alcohol during the meeting. Few people remember the recently taken Nurofen, a painkiller that so often saves us in moments of agony.
Nurofen - brief instructions
Nurofen is a fairly well-known medicine that, in addition to its low price, has a lot of advantages:
- relieves pain;
- relieves fever;
- eliminates inflammatory manifestations;
- can be used by people of any age, including small children;
- Various release options make it possible to take Nurofen in any situation with different localization of the inflammatory process.
The main substance of the drug that leads to this result is ibuprofen.
The different dosages of ibuprofen included in Nurofen determine the release form:
- Nurofen active - 200 mg of ibuprofen in tablets for sublingual use;
- Nurofen for children - sweet syrup with different flavors, containing 100 mg of ibuprofen per 5 ml;
- rectal suppositories for children - 60 mg of ibuprofen per suppository;
- Nurofen Ultracap - produced in the form of capsules containing 200 mg of active ingredient;
- Nurofen period - a tablet containing an increased amount of ibuprofen - 300 mg. Long-acting agent;
- Nurofen Forte and Nurofen Ultracap Forte - contain the most powerful dose of ibuprofen - 400 mg per tablet;
- Nurofen Plus - in addition to 200 mg of ibuprofen, it contains 10 mg of codeine, which enhances pain relief;
- Nurofen gel - includes 5 g. ibuprofen per 100 g. medicines.
All Nurofen release options are used to remove inflammatory processes in tissues, to relieve fever and for pain relief in different situations: for menstrual, dental, muscle pain, pain during labor activity, at tumor processes and pain from injuries.
Nurofen gel is used as local anesthetic for sprains, sports injuries, back pain of various origins and arthritis.
Nurofen is taken urgently - for sudden pain, and in long courses - for chronic diseases.
Patients should be careful when taking medication if they are taking any other medications. Nurofen may not be combined with all medications; some interactions can have dire consequences in the form of stomach bleeding, blood clotting disorders, and kidney complications.
In the video about the drug Nurofen:
Interaction with alcohol
The instructions do not recommend using Nurofen in combination with alcohol. But it is completely unclear why you should not drink alcohol with Nurofen, so many people ignore this warning and calmly drink alcohol after relieving a painful attack. But doing this is extremely dangerous!
Any alcoholic drink has a special effect on the rate of breakdown of drugs in the liver. Acceleration of metabolism can lead to the immediate removal of the drug from the patient’s body and the sudden return of pain, which in the minutes of meeting with nice people it will turn out to be completely inappropriate. As a result, the patient will be forced to take the painkiller again, which, against the background of the alcohol he has just drunk, contributes to an overdose of the drug, and also causes a serious blow to the liver cells - hepatocytes.
In addition to these far from harmless consequences, Nurofen has the ability to cause internal bleeding, promotes the development of ulcers on the mucous membranes of the stomach and intestines, and the manifestation allergic reactions and disorders of the nervous system. No one knows which of these deviations may manifest in a particular person.
Possible consequences
The interaction of alcohol and painkillers may not have significant consequences, but it should be understood that regular use of analgesics and ethanol will ultimately not lead to anything good. On the part of the liver, after some time, it is quite possible for the rapid development of drug-induced hepatitis or cirrhosis due to the excessive load during the breakdown of drugs and ethyl alcohol.
The gastric mucosa is usually the first to take on the toxic impact after alcoholic libations. Inflamed by the action of alcohol, the mucous membrane becomes ulcerated, and taking Nurofen only aggravates the situation. Therefore, it is likely that stomach bleeding as a result of such a union.
The simultaneous use of ibuprofen with ethanol leads to increased side effects from the drug, in particular it is known Negative influence on nervous system: a person becomes irresistibly sleepy, a headache and a feeling of weakness appear, and his mood worsens. The heart muscle also suffers due to improper functioning circulatory system- appears palpitations, symptoms may appear.
Some patients prone to allergic rash, may discover an unpleasant consequence of the combination of alcohol and Nurofen in the form of urticaria or even angioedema, which threatens immediate departure from the celebration site to the intensive care unit.
Similar results are unlikely to appear if you drink small doses of weak alcohol after drinking a painkiller tablet in the morning, but if you systematically drink Nurofen with vodka, the symptoms described above will certainly appear very soon.
How to take it correctly?
As is the case with many medications, Nurofen and alcohol should definitely be separated in time. How long after an analgesic can you drink alcohol? The best thing to do after taking Nurofen is not to drink alcohol at all for 12 hours. But if this has already happened, then it is worth delaying the intake of alcoholic beverages for at least 6 hours until the half-life of the drug from the body passes.
As for Nurofen after alcohol, this drug is also unlikely to be suitable for relieving pain after a stormy feast. For this purpose, it is better to use other drugs. It will be possible to take Nurofen after drinking only after the alcohol has been completely removed from the body and the gastric mucosa has been calmed.
conclusions
Can I take Nurofen with alcohol? It is not in vain that the instructions for taking the medicine warn us that the compatibility of alcohol with taking the medicine is unacceptable. To avoid manifestation unpleasant consequences Perhaps one should not neglect such warnings.
Every parent has faced high temperature and pain in the child. There can be many reasons: teething, pain when stretching, due to colds, infectious diseases. To alleviate the course of the disease, doctors prescribe anti-inflammatory, antipyretic, and painkillers. Below we will consider which is better for children - Nurofen or Efferalgan.
Nurofen
Non-narcotic analgesic with a pronounced antiphlogistic, antipyretic, antiphlogistic effect. The composition includes the active ingredient - ibuprofen. Not recommended for use medicinal product with other non-steroidal anti-inflammatory drugs, acetylsalicylic acid.
Nurofen suppositories are an excellent remedy for children from 3 months to 12 years, in whom the disease is accompanied by frequent regurgitation and vomiting. This form of the drug is safe in the presence of stomach diseases, as it does not irritate its walls. The suppository contains 60 mg of ibuprofen.
Nurofen suspension is available in 2 modifications - with orange and strawberry flavors. 5 ml of the drug contains 100 mg of ibuprofen. The product is approved for use in infants from 3 months of age.
Nurofen tablets can be given to children over 6 years of age; one dosage unit contains 200 mg of the active ingredient.
- prone to allergies;
- with organ diseases gastrointestinal tract(ulcerative, erosive lesions);
- for hemophilia;
- renal failure;
- liver failure;
- bronchial asthma.
In case of overdose or long-term use of the drug in children, adverse reactions may develop:
- allergy;
- visual impairment;
- vomiting, nausea, vomiting, heartburn;
- dizziness;
- sleep quality disturbance;
- hearing loss, tinnitus;
- hypertension, tachycardia;
- development of nephrotic syndrome.
An antipyretic drug belongs to the group of non-narcotic analgesics. Active component is paracetamol. Suitable for use in the youngest patients aged from 1 month to 12 years.
Efferalgan is recommended for relieving mild pain during teething, neuralgia, muscle pain, headaches, toothache, and reducing body temperature due to colds and infectious pathologies. For babies it is available in the form of suppositories and syrup.
Read also: How soon can Nurofen be given to children again?
One suppository contains 80 mg and 150 mg of paracetamol. Recommended for use in children from 1 month to 3 years. 1 ml of suspension contains 30 mg of the active ingredient.
- tendency to be allergic to active substance, auxiliary components;
- liver dysfunction;
- impaired renal function.
With prolonged use, exceeding permissible dosage Possible side effects:
- diarrhea, nausea, vomiting, abdominal pain;
- allergic reactions;
- hypotension, anemia;
- kidney dysfunction.
Which is better for children - Nurofen or Efferalgan
Every parent carefully chooses medications for their child. When choosing, you should take into account contraindications. After each use of the product, it is necessary to monitor the child’s reaction. Do not neglect the recommendations of your pediatrician, who will help you choose an effective analgesic and antipyretic drug with a minimum number of contraindications.
The downside of any syrup is its sweet, cloying taste - not every child can take the medicine, and after taking it, a response in the form of vomiting is possible. Auxiliary components act irritatingly on the walls digestive organs- It is not recommended to give a child Nurofen or Efferalgan to drink if there is an increased gag reflex, rotavirus, or diseases of the digestive tract.
According to reviews of mothers on the Internet, Nurofen does not act for long - for 2-3 hours, after which a gradual increase in temperature occurs. The disadvantage of the drug is its low efficiency - at high thermometer readings it is not possible to completely reduce the temperature.
Despite the low efficiency and short duration of action, in addition to a pronounced analgesic and antipyretic effect, Nurofen has an antiphlogistic effect, which in case of infectious and inflammatory pathologies stops the source of inflammation.
Efferalgan does not have an anti-inflammatory effect, but it effectively fights fever, normalizing temperature at critical levels. The drug is not used for severe pain.
Drug compatibility
Parents in the absence of effect or short-term effect of one medicine resort to using something else, thinking that they are helping the child cope with fever and pain.
Nurofen and Analgin are drugs used to eliminate fever and pain.
How they affect the body
They inhibit the synthesis of prostaglandins by blocking the enzyme cyclooxygenase. Anesthetizes and eliminates signs of hyperthermia.
Nurofen and Analgin are drugs used to eliminate fever and pain.
Nurofen
Provides rapid analgesic, antipyretic and anti-inflammatory effect.
Analgin
What is better and what is the difference between Nurofen and Analgin
Nurofen is pharmacological product containing ibuprofen. Can be used by patients of different age groups:
- children from 3 months ( liquid form drug for teething, symptoms of colds, flu, chickenpox and other childhood infections);
- adults (with pain syndromes of various etiologies, incl. at elevated temperature body or exacerbation of pancreatitis).
The active component of Analgin is metamizole sodium. Unlike Nurofen, this drug is banned in many countries of the world due to its toxicity. Can be prescribed to persons over 15 years of age.
Indications for joint use
In most cases, joint administration is not prescribed, since there is a possibility of developing adverse reactions body. It is believed that it is better to take these drugs separately, with an interval of at least 4 hours.
Joint use is possible only in severe cases pathological process when other drugs are ineffective. Moreover, only a doctor can determine the proportions and regimen of administration.
How to take Nurofen and Analgin together
Maximum single dose when taking drugs together for adults - 1 tablet of each of them (in a 1:1 ratio).
special instructions
When using a combination of drugs, do not take more than 1 time. When consumed in inadequate dosages, it leads to severe physiological pathologies.
Nurofen can be prescribed to patients with diabetes.
Do not combine with alcohol-containing drugs.
With bronchial asthma and hay fever, this combination can provoke bronchospasm.
Prescribed with caution when peptic ulcers Gastrointestinal tract, liver and kidney diseases.
Pregnancy and lactation
Childhood
Together they are prescribed only in cases of urgent need.
Elderly age
Carefully.
Side effects of Nurofen and Analgin
After joint reception may occur:
- nausea (up to attacks of vomiting);
- diarrhea;
- epigastric discomfort;
- ulcerative lesions of the gastrointestinal tract;
- internal bleeding;
- dizziness;
- general weakness;
- skin rashes;
- thrombocytopenia;
- agranulocytosis;
- leukopenia, etc.
Contraindications to the use of Nurofen and Analgin
- individual intolerance to the components of medications;
- bronchial asthma;
- stomach ulcers with episodes of bleeding;
- thyrotoxicosis and other pathologies of the thyroid gland;
- renal and/or liver failure;
- heart disease;
- bleeding disorders.
In addition, it is not prescribed during pregnancy and lactation.
