Calcium gluconate appeared on the pharmaceutical market quite a long time ago and was able to win the trust of more than one patient. Its direct purpose is hypocalcemia - low levels of total calcium in the blood plasma.
But if you look at the instructions for the drug, you will see a very extensive list of indications for use. One of them is allergic reactions of different nature and etymology. Calcium gluconate for allergies is positioned by many doctors as an effective pharmacological agent.
In this article we will look at why doctors prescribe Calcium gluconate, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS People who have already used Calcium Gluconate can be read in the comments.
Composition and release form
Available in tablet form and in the form of a solution, which contain active substance‒ calcium gluconate monohydrate, as well as auxiliary components.
- The tablets contain 500 mg of the active ingredient, 10 pieces in one blister.
- 1 ml of solution for injection contains 0.1 g of gluconate; there are ampoules of 1 and 5 ml.
Clinical and pharmacological group: a drug that replenishes calcium deficiency in the body.
What is Calcium gluconate used for?
The drug is prescribed to correct calcium deficiency in the blood of any origin. Cases in which the instructions provide for the use of the drug:
- Hypocalcemia of various etiologies;
- Nephritis, chronic renal failure(hyperphosphatemia);
- IN complex treatment drug and other types of allergies;
- Inflammatory processes, with symptoms of tissue swelling;
- Hyperkalemic form of paroxysmal myoplegia;
- For bleeding various localizations(nasal, uterine, from the digestive tract, pulmonary);
- Increased intake of calcium ions (pregnancy, accelerated growth, lactation period);
- Low calcium content in food;
- Enhanced calcium excretion (after long-term treatment with glucocorticosteroids, diuretics, antiepileptic drugs);
- Disorders of calcium metabolism (postmenopausal period);
- Decreased function of the parathyroid glands (manifests as latent tetany, osteoporosis);
- All types of disorders in vitamin D metabolism (spasmophilia, osteomalacia);
- Eclampsia;
- Liver damage due to various intoxications, development of parenchymal hepatitis;
- In case of poisoning with oxalic acid, fluoric acid, magnesium salts.
Calcium gluconate is effective during pregnancy, lactation, increased growth, postmenopausal period, and with a diet lacking calcium.
pharmachologic effect
Calcium gluconate replenishes the deficiency of calcium - a substance necessary for the formation bone tissue, smooth contractions, skeletal muscles, transmission of nerve impulses, myocardial activity, blood coagulation.
The use of calcium gluconate is less irritating than calcium chloride.
Instructions for use
According to the instructions for use, Calcium gluconate tablets are taken before meals or 1-1.5 hours after meals. It is recommended to take the medicine with milk. Grind before use.
- Adults take one to three grams 2-3 times a day.
- Children under one year old are given 0.5 g of the drug, at the age of 2-4 years - 1 g, 5-6 years - 1-1.5 g, 7-9 years - 1.5-2 g, 10-14 years - 2-3 gr. Calcium gluconate tablets are given to children 2-3 times a day.
- Pregnant and nursing mothers – 1-3 g 2-3 times a day (maximum daily dose– 9 g).
Contraindications
The instructions for use contain a number of contraindications when the drug is not recommended for use, including:
- Urolithiasis disease;
- Excessive excretion of calcium in urine;
- High sensitivity to the drug;
- Increased content of calcium ions in blood serum;
- Systemic damage lung tissue with the formation of granulomas.
Taking cardiac glycosides is also a contraindication, due to the high likelihood of developing arrhythmia. Calcium gluconate is prescribed with extreme caution to patients prone to low water levels in the body due to diarrhea.
Side effects
- Long-term use of calcium in the form of tablets can cause constipation, irritation of the gastrointestinal mucosa, and hypercalcemia.
The solution may cause nausea, vomiting, diarrhea, and bradycardia. Intramuscular administration medications can cause the development of necrosis.
In case of overdose, hypercalcemia is possible. IN in this case Calcitonin can be used as an antidote, which is administered intravenously at the rate of 5-10 MO per 1 kilogram of body weight per day (the drug must be diluted in 500 ml of isotonic sodium chloride solution and administered drip-wise over 6 hours in 2-4 doses).
Analogs
Structural analogues of the active substance:
- Calcium gluconate B. Brown;
- Stabilized calcium gluconate;
- Calcium gluconate-Vial;
- Calcium gluconate-LekT;
- Calcium gluconate solution for injection 10%.
Attention: the use of analogues must be agreed with the attending physician.
Prices
The average price of CALCIUM GLUCONATE in pharmacies (Moscow) is 15 rubles.
Conditions for dispensing from pharmacies
The drug is approved for use as a means of OTC.
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Instructionsfor medical use
medicine
CALCIUM GLUCONATE
Tradename
Calcium gluconate
International nonproprietary name
Dosage form
Tablets 0.5 g
Compound
One tablet contains
active substance- calcium gluconate monohydrate 500 mg,
Excipients: potato starch, talc, calcium stearate.
Description
Pills white flat-cylindrical, with chamfer and notch. Marbling is allowed on the surface of the tablets.
Pharmacotherapeutic group
Mineral supplements. Calcium preparations
ATX code A12AA03
Pharmacological properties
Pharmacokinetics
Approximately 1/5-1/3 of the orally administered drug is absorbed into small intestine. This process depends on the influence of vitamin D, the acidity of the intestinal contents, diet and the presence of factors that can bind calcium ions. Calcium absorption increases with its deficiency in the body and in food. About 20% of calcium is excreted by the kidneys, the remaining 80% is removed with the contents of the intestine (calcium is actively released through the wall terminal department intestines).
Pharmacodynamics
Calcium ions take part in the formation of bone tissue, the process of blood clotting, and are necessary to maintain stable cardiac activity and carry out the processes of transmission of nerve impulses. A decrease in the content of calcium ions in blood plasma and tissues can lead to the development of various pathological processes. Hypocalcemia leads to dysfunction of skeletal and smooth muscles, of cardio-vascular system, disruption of the blood coagulation system, development of osteoporosis.
Indications for use
Hypoparathyroidism (latent tetany, osteoporosis), vitamin D metabolism disorders: rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal failure
Increased need for calcium (pregnancy, period breastfeeding, period of increased growth of the body), insufficient calcium content in food, disturbance of its metabolism (in the postmenopausal period)
Increased excretion of calcium from the body of various origins (long-term bed rest, chronic diarrhea, secondary hypocalcemia due to long-term use of diuretics, antiepileptic drugs and glucocorticosteroids)
Poisoning with magnesium salts, oxalic and fluoric acids and their soluble salts (when interacting with calcium gluconate, insoluble and non-toxic calcium oxalate and calcium fluoride are formed)
Hyperkalemic form of paroxysmal myoplegia
Directions for use and doses
Before starting use, consult your doctor.
The drug is taken orally before meals or 1.5-2 hours after meals, washed down with milk.
The dosage regimen and duration of taking the drug for each indication depend on the patient’s condition and are determined by the doctor in accordance with the treatment regimens given below. Adults and children over 14 years old - 1.0-3.0 g (2-6 tablets) 2-3 times a day; children from 3 to 5 years old - 1.0 g (2 tablets) 2-3 times a day; from 5 to 7 years - 1.0-1.5 g (2-3 tablets) 2-3 times a day; from 7 to 10 years - 1.5-2.0 g (3-4 tablets) 2-3 times a day; from 10 to 14 years - 2.0-3.0 g (4-6 tablets) 2-3 times a day.
The course of taking the drug depends on the patient’s condition and is recommended by the doctor.
Side effects
Irritation of the mucous membrane gastrointestinal tract
Hypercalcemia
Allergic reactions
Nausea, vomiting, diarrhea
Rarely- hyperkalemia,
Arrhythmia,
confusion,
Sense of anxiety
Shortness of breath or difficulty breathing
Feeling of heaviness or weakness in the legs
If any of the side effects indicated in the instructions get worse, or you notice any other side effects, not listed in the instructions, inform your doctor.
Contraindications
Hypersensitivity
Hypercalcemia (calcium ion concentration should not exceed 12 mg% = 6 mEq/L)
Severe hypercalciuria
Nephrourolithiasis (calcium)
Sarcoidosis
Severe renal failure
Concomitant use of cardiac glycosides (risk of arrhythmias)
Children under 6 years old
Carefully
Dehydration, electrolyte disturbances
Diarrhea, history of calcium nephrolithiasis
Malabsorption syndrome, widespread atherosclerosis
Moderate chronic renal and/or cardiovascular failure
Hypercoagulability, ventricular fibrillation
If there is one of listed diseases Before taking the drug, you must consult a doctor
Drug interactions
Calcium gluconate is pharmaceutically incompatible with carbonates, salicylates, sulfates, as it precipitates them with the formation of insoluble and sparingly soluble calcium salts.
Concomitant use of calcium gluconate with thiazide diuretics leads to increased hypercalcemia.
Taking calcium gluconate reduces the effect of calcitonin in hypercalcemia, and also reduces the bioavailability of phenytoin.
Due to the formation of insoluble complexes, it is incompatible with licorice root preparations and tetracycline antibiotics (reduces the antibacterial effect).
Slows down the absorption of digoxin, tetracyclines, iron preparations, clindamycin phosphate, hydrocortisone succinate, salicylates for oral administration (the interval between taking calcium gluconate and the listed drugs should be at least 2 hours). With the simultaneous use of calcium gluconate with quinidine, intraventricular conduction may slow down and the toxicity of quinidine may increase. At joint use enhances the antiresorptive effect of vitamin D, ossien hydroxyapatite complex, anabolic steroids and estrogens. Enhances the hemostatic effect of vitamin K. Reduces the toxicity of bisphosphonates and fluorides when used together. Pharmaceutically incompatible with magnesium preparations.
special instructions
The drug does not affect the ability to drive a car or control various mechanisms, as well as engage in other potentially dangerous species activities that require increased attention and speed of mental and motor reactions. Patients with a tendency to form kidney stones are advised to increase their fluid intake.
Use during pregnancy and breastfeeding
During pregnancy and during breastfeeding, the use of the drug is possible on the recommendation of a doctor. The daily dose of calcium during pregnancy should not exceed 1500 mg. If necessary, use during lactation should stop breastfeeding.
Overdose
Symptoms: increased level serum calcium. In case of chronic overdose of calcium preparations, general and muscle weakness, depression, mental disorders, loss of appetite, nausea, vomiting, constipation, decreased blood pressure, heart rhythm disturbance.
Treatment: discontinuation of the drug, parenteral administration of calcitonin at a dose of 5-10 IU/kg/day in 500 ml of 0.9% sodium chloride solution for 6 hours.
Release form and packaging
10 tablets in a contoured cell-free package made of a combination of paper and cardboard material.
Contour cellless packaging, together with instructions for use (insert notes) in the state and Russian languages, are placed in group containers.
The number of instructions for use (insert notes) must correspond to the number of packages.
Storage conditions
Store at a temperature not exceeding 25 °C.
Keep out of the reach of children!
Shelf life
The drug should be used before the date indicated on the package!
Conditions for dispensing from pharmacies
Over the counter
Manufacturer
Registration Certificate Holder
OJSC Pharmstandard-Leksredstva, Russia
Address of the organization that accepts claims from consumers regarding product quality on the territory of the Republic of Kazakhstan
OJSC Pharmstandard-Leksredstva, 305022,
Russia, Kursk, 2nd Aggregatnaya st., 1a/18
active substance: 1 tablet contains calcium gluconate in terms of 100% substance - 500 mg;
Excipients: potato starch, croscarmellose sodium, talc, calcium stearate.
Dosage form
Pills.
Tablets are white, flat-cylindrical, scored and chamfered.
Manufacturer name and location
PJSC "Kievmedpreparat" Ukraine, 01032, Kyiv, st. Saksaganskogo, 139.
PJSC "Galichfarm", Ukraine, 79024, m. Lvov, st. Opryshkivska, 6/8.
Pharmacotherapeutic group
Calcium preparations. ATS code 12 A03.
Calcium gluconate is a calcium salt of gluconic acid, which contains 9% calcium. Calcium ions take part in the transmission of nerve impulses, the contraction of smooth and skeletal muscles, the functioning of the myocardium, and blood clotting processes; they are necessary for the formation of bone tissue and the normal functioning of other systems and organs. The concentration of calcium ions in the blood decreases with many pathological processes; Severe hypocalcemia contributes to the occurrence of tetany. Calcium gluconate, in addition to eliminating hypocalcemia, reduces vascular permeability, has antiallergic, anti-inflammatory, hemostatic effects, and also reduces exudation. Calcium ions are a plastic material for the skeleton and teeth, participate in various enzymatic processes, regulate the speed of nerve impulses and permeability cell membranes. Calcium ions are necessary for the process of neuromuscular transmission and to maintain the contractile function of the myocardium. Unlike calcium chloride, calcium gluconate has a weaker muscle irritant effect.
When taken orally, calcium gluconate is partially absorbed, mainly in the small intestine. The maximum concentration in blood plasma is achieved after 1.2-1.3 hours. The half-life of ionized calcium from blood plasma is 6.8-7.2 hours. Penetrates the placental barrier and into breast milk. It is excreted from the body in urine and feces.
Indications for use
Diseases accompanied by hypocalcemia, increased permeability of cell membranes, impaired conduction of nerve impulses in muscle tissue. Hypoparathyroidism (latent tetany, osteoporosis), vitamin D metabolism disorders (rickets, spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal failure. Increased need for calcium (period intensive growth in children and adolescents, pregnancy, breastfeeding), insufficient Ca 2+ content in food, disturbance of its metabolism in the postmenopausal period, bone fractures. Increased excretion of Ca 2+ (prolonged bed rest, chronic diarrhea, hypocalcemia with long-term use of diuretics, antiepileptics medicines, glucocorticosteroids). IN complex therapy: bleeding of various etiologies, allergic diseases(serum sickness, urticaria, febrile syndrome, pruritic dermatoses, angioedema); bronchial asthma, dystrophic alimentary edema, pulmonary tuberculosis, eclampsia, parenchymal hepatitis, toxic lesions liver, nephritis. Poisoning with magnesium salts, oxalic acid, soluble salts of fluoric acid (when interacting with calcium gluconate, insoluble and non-toxic calcium oxalate and calcium fluoride are formed).
Contraindications
Hypersensitivity to the components of the drug, hypercalcemia, severe hypercalciuria, hypercoagulation (increased blood clotting), tendency to thrombus formation, severe atherosclerosis, nephrourolithiasis (calcium), severe renal failure, sarcoidosis, taking digitalis drugs.
Proper safety precautions for use
When used in patients receiving cardiac glycosides and/or diuretics, as well as when long-term treatment the concentration of calcium and creatinine in the blood should be monitored. If their concentration increases, the dose of the drug should be reduced or its use should be temporarily stopped. Due to the fact that vitamin D 3 increases the absorption of calcium from the gastrointestinal tract, in order to avoid an overdose of calcium, it is necessary to take into account the intake of vitamin D 3 and calcium from other sources.
Patients with slight hypercalciuria (more than 300 mg/day = 7.5 mmol/day), mild renal dysfunction, urolithiasis history, should be prescribed with caution and the level of urinary calcium excretion regularly monitored. If necessary, reduce the dose of the drug or discontinue it. Patients with a tendency to form stones in urinary tract During treatment, it is recommended to increase the volume of fluid consumed.
When treating with the drug, you should avoid taking high doses of vitamin D or its derivatives, unless there are special indications for this.
An interval of at least 3 hours should be maintained between taking calcium gluconate tablets and oral medications estramustine, etidronate and other bisphosphonates, phenytoin, quinolones, tetracycline antibiotics, oral iron supplements and fluoride supplements.
Use during pregnancy or breastfeeding
The use of the drug is permissible taking into account the ratio of benefit to the woman/risk to the fetus (child), which is determined by the doctor. When using calcium supplements during breastfeeding, it may pass into breast milk.
The ability to influence reaction speed when driving vehicles or operating other mechanisms
The drug does not affect the reaction rate when driving vehicles or working with complex mechanisms.
Children
The drug is used for children aged 3 years and older.
Directions for use and doses
Prescribed orally before meals. The tablet must be chewed or crushed.
For adults and children over 14 years of age, the drug is prescribed in a single dose of 1-3 g (2-6 tablets), for children aged 3 to 4 years - 1 g (2 tablets), from 5 to 6 years - 1-1. 5 g (2-3 tablets), from 7 to 9 years - 1.5-2 g (3-4 tablets), from 10 to 14 years - 2-3 g (4-6 tablets) 2-3 times per day. The daily dose for elderly patients should not exceed 2 g (4 tablets) per day.
The duration of treatment is determined by the doctor individually, depending on the patient’s condition.
Overdose
With long-term use in high doses, hypercalcemia with the deposition of calcium salts in the body is possible, and dyspepsia is possible. The likelihood of developing hypercalcemia increases with simultaneous treatment high doses of vitamin D or its derivatives.
Symptoms of hypercalcemia: drowsiness, weakness, anorexia, abdominal pain, vomiting, nausea, constipation, polydipsia, polyuria, fatigue, irritability, bad feeling, depression, dehydration, possible disorders heart rate, myalgia, arthralgia, arterial hypertension.
Treatment: drug withdrawal; in severe cases - parenteral calcitonin at a dose of 5-10 IU/kg body weight per day (diluted in 500 ml of sterile physiological sodium chloride solution, intravenously drip over 6 hours. Slow intravenous jet administration is possible 2-4 times a day).
Side effects
The drug is usually well tolerated, but sometimes disturbances are possible:
from the digestive tract: nausea, vomiting, diarrhea, pain in the epigastric region, constipation; with long-term use in high doses - the formation of calcium stones in the intestines;
from the cardiovascular system: bradycardia;
from the side of metabolism: hypercalcemia, hypercalciuria;
from the urinary system: renal dysfunction ( frequent urination, swelling of the lower extremities).
Allergic reactions may occur.
These phenomena quickly disappear after reducing the dose or discontinuing the drug.
Interaction with other drugs and other types of interactions.
The drug slows down the absorption of estramustine, etidronate and other bisphosphonates, quinolones, tetracycline antibiotics, oral iron supplements and fluoride preparations (the interval between doses should be at least 3 hours). Calcium gluconate reduces the bioavailability of phenytoin. When taken simultaneously with vitamin D or its derivatives, calcium absorption increases. Cholesterolamine reduces calcium absorption in the digestive tract. When used together with cardiac glycosides, the cardiotoxic effects of the latter are enhanced. GCS reduce calcium absorption. When combined with thiazide diuretics, it may increase the risk of developing hypercalcemia. The drug may reduce the effect of calcitonin in hypercalcemia, the bioavailability of phenytoin, and the effect of calcium channel blockers. When used simultaneously with quinidine, intraventricular conduction may slow down and the toxicity of quinidine may increase.
Forms insoluble or slightly soluble calcium salts with carbonates, salicylates, and sulfates.
Calcium absorption from the gastrointestinal tract can be reduced by certain types of food (spinach, rhubarb, bran, grains).
Best before date
Storage conditions
Store in original packaging at a temperature not exceeding 25 ºС.
Keep out of the reach of children.
Instructions for use of dietary supplement
Calcium gluconate 500 mg
Source of calcium
How the ingredients work
Calcium. The physiological significance of calcium in the body is diverse. It is part of the main mineral component of bone tissue - oxyapatite, whose microcrystals form the rigid structure of bone tissue. Calcium ions impart stability to cell membranes by forming bonds between negatively charged groups of phospholipids, structural proteins and glycoproteins. Important role belongs to calcium in the implementation of intercellular interactions, which ensure ordered adhesion (cell adhesion) during tissue formation.
Along with plastic and structural functions calcium plays a decisive role in many physiological and biochemical processes: it is necessary for normal excitability nervous system and muscle contractility, is an activator of a number of enzymes and hormones, as well as an essential component of the blood coagulation system.
Compound
calcium gluconate, corn starch (carrier), calcium stearate plant origin and amorphous silicon dioxide (anti-caking agents).
Adults and children over 14 years old - 2 tablets 2 times a day with meals. Duration of treatment is 1-2 months. If necessary, the reception can be repeated.
Contraindications
Persons with individual intolerance to the product, pregnant or breastfeeding women. It is recommended to consult a doctor before use.
Release form
Pills
Number of tablets per package
20, 120 tablets, 0.53 g each
Best before date
Storage conditions
Store at a temperature not exceeding 25°C
Manufacturer
A drug that replenishes calcium deficiency in the body
Active substance
Calcium gluconate monohydrate
Release form, composition and packaging
◊ Pills white, flat-cylindrical, with chamfer and notch.
Excipients: potato starch 23 mg, talc 5 mg, calcium stearate monohydrate 2 mg.
10 pieces. - cellless contour packages (1) - cardboard packs.
10 pieces. - cellless contour packages (2) - cardboard packs.
10 pieces. - contour cellular packaging (1) - cardboard packs.
10 pieces. - contour cell packaging (2) - cardboard packs.
pharmachologic effect
The calcium supplement replenishes the deficiency of calcium ions necessary for the transmission of nerve impulses, contraction of skeletal and smooth muscles, myocardial activity, bone tissue formation, and blood clotting.
Pharmacokinetics
Approximately 1/5-1/3 of the orally administered drug is absorbed into the small intestine; this process depends on the presence of D, pH, diet and the presence of factors capable of binding calcium ions. The absorption of calcium ions increases with calcium deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the remaining amount (80%) is removed with the contents of the intestine.
Indications
Diseases accompanied by hypocalcemia, increased permeability of cell membranes (including blood vessels), disruption of the conduction of nerve impulses in muscle tissue.
Hypoparathyroidism (latent tetany, osteoporosis), vitamin D metabolism disorders: rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic.
Increased need for calcium ions (pregnancy, lactation, period of increased growth of the body), insufficient content of calcium ions in food, disturbance of its metabolism (in the postmenopausal period).
Enhanced excretion of calcium ions (prolonged bed rest, chronic, secondary hypocalcemia due to long-term use of diuretics and antiepileptic drugs, glucocorticosteroids).
Poisoning with salts of magnesium ions, oxalic and fluoric acids and their soluble salts (when interacting with calcium gluconate, insoluble and non-toxic calcium oxalate and calcium fluoride are formed).
Hypercalcemic form of paroxysmal myoplegia.
Contraindications
Hypersensitivity, hypercalcemia (the concentration of calcium ions should not exceed 12 mg% ~ 6 mEq/l), severe hypercalciuria, nephrourolithiasis (calcium), sarcoidosis, simultaneous use of cardiac glycosides (risk of arrhythmias), childhood up to 3 years.
Carefully. Dehydration, electrolyte disturbances (risk of developing hypercalcemia), diarrhea, malabsorption syndrome, slight hypercalciuria, moderate chronic renal failure, chronic failure, widespread atherosclerosis, hypercoagulation, calcium nephrourolithiasis (history).
Dosage
Grind before use.
Orally, before meals or 1-1.5 hours after consumption (with milk). Adults - 1-3 g 2-3 times a day (maximum daily dose - 9 g).
Pregnant and nursing mothers- 1-3 g 2-3 times a day (maximum daily dose - 9 g).
For children: 3-4 years - 1 g (maximum daily dose - 3.0 g); 5-6 years - 1-1.5 g (maximum daily dose - 4.5 g); 7-9 years – 1.5-2 g (maximum daily dose - 6 g); 10-14 years - 2-3 g (maximum daily dose - 9 g); frequency of administration - 2-3 times a day.
Side effects
Constipation, irritation of the gastrointestinal mucosa, hypercalcemia.
Overdose
Symptoms: development of hypercalcemia.
Treatment: calcitonin is administered 5-10 IU/kg/day. (diluted in 500 ml of 0.9% solution). Duration of administration 6 hours.
Drug interactions
Forms insoluble complexes with tetracycline antibiotics (reduces the antibacterial effect).
When used simultaneously with quinidine, intraventricular conduction may slow down and the toxicity of quinidine may increase.
Slows down the absorption of digoxin and oral iron supplements (the interval between doses should be at least 2 hours).
When combined with thiazide diuretics, it may increase hypercalcemia. Reduces the effect of calcitonin in hypercalcemia. Reduces the bioavailability of phenytoin.
