Antiseptic. When applied externally, it has an antimicrobial effect. Active against gram-positive and gram-negative bacteria and viruses. Denatures proteins of microorganisms.
Antiseptic activity increases with increasing ethanol concentration.
To disinfect the skin, use a 70% solution, which penetrates into the deeper layers of the epidermis better than 95% and has a tanning effect on the skin and mucous membranes.
When used systemically, it has the ability to cause analgesia and general anesthesia. The cells of the central nervous system are most sensitive to ethanol, especially the cells of the cerebral cortex, on which ethanol causes characteristic alcoholic excitation associated with a weakening of inhibition processes. Then there is also a weakening of excitation processes in the cortex, depression of the spinal and medulla oblongata with suppression of the respiratory center.
Is a solvent for a number medicines, as well as an extractant for a number of substances contained in medicinal plant materials.
Pharmacokinetics
Ethanol is metabolized in the liver with the participation of the CYP2E1 isoenzyme, of which it is an inducer.
Indications
Treatment of inflammatory skin diseases V initial stage(furuncle, felon, mastitis); treatment of the surgeon’s hands (Furbringer, Alfred methods), surgical field(including in persons with hypersensitivity to other antiseptics, in children and during operations on areas with thin skin in adults - in the neck, face).
As a local irritant drug.
For the manufacture of dosage forms for external use, tinctures, extracts.
Conservation of biological material.
Dosage regimen
It is used depending on the indications and dosage form.
Side effect
Allergic reactions, skin burns, hyperemia and soreness of the skin at the site of application of the compress. When applied externally, it is partially absorbed through the skin and mucous membranes and may have a systemic toxic effect (CNS depression).
Contraindications for use
Hypersensitivity to ethanol.
Use during pregnancy and breastfeeding
Use during pregnancy and lactation is permitted if the benefit to the mother outweighs the potential risk to the fetus and child.
Use in children
Overdose
No data available.
Drug interactions
When used simultaneously, it enhances the effect of drugs that have a depressant effect on the central nervous system, cardiovascular system, respiratory center.
When taken orally with drugs that have an inhibitory effect on the enzyme aldehyde dehydrogenase (which is involved in the metabolism of ethyl alcohol), the concentration of ethanol metabolite, acetaldehyde, increases, causing flushing, nausea, vomiting, general malaise, tachycardia, and decreased blood pressure.
Conditions for dispensing from pharmacies
On prescription.
Storage conditions and periods
In a well-closed container, away from sources of bulk, at a temperature not exceeding 25°C. Keep out of the reach of children. Shelf life - 2 years.
Should not be taken orally during drug treatment.
When used externally, ethanol is partially absorbed through the skin and mucous membranes, which should be taken into account when used in children.
LP-005831Trade name:
Medical antiseptic solution
International nonproprietary or generic name:
Dosage form:
concentrate for preparing a solution for external use
Compound:
Active substance:
ethanol (ethyl alcohol) 95% – 100.0 ml.
Description:
transparent, colorless, mobile liquid with a characteristic alcoholic odor.
Pharmacotherapeutic group:
ATX code:
Pharmacological properties
Pharmacodynamics
Antimicrobial agent, when applied externally, has an antiseptic effect (denatures the proteins of microorganisms). Active against gram-positive and gram-negative bacteria and viruses. Antiseptic activity increases with increasing ethanol concentration.
To disinfect the skin, use a 70% solution, which penetrates into the deeper layers of the epidermis better than a 95% solution, which has a tanning effect on the skin and mucous membranes.
Pharmacokinetics
When applied externally, it is absorbed from the surface of the skin and mucous membranes into the systemic circulation. Metabolized in the liver with the participation of the CYP2E1 isoenzyme, of which it is an inducer.
Indications for use
Used as an antiseptic and disinfectant in the treatment of the initial stages of diseases (furuncle, panaritium, mastitis); when treating the surgeon's hands (Furbringer, Alfred methods), the surgical field (including in persons with hypersensitivity to other antiseptics, in children and during operations on areas with thin skin in adults - neck, face).
Contraindications
Hypersensitivity.
Carefully
Pregnancy, period breastfeeding, childhood.
Use during pregnancy and breastfeeding
No special studies have been conducted on the use of the drug during pregnancy and breastfeeding. During pregnancy and breastfeeding, it is used only if the expected benefit to the mother outweighs the potential risk to the fetus and child.
Directions for use and doses
Externally, in the form of lotions, compresses, rubdowns.
To treat the surgical field and preoperative disinfection of the surgeon’s hands, use a 70% solution; for compresses and rubdowns (to avoid burns), it is recommended to use a 40% solution.
The 95% solution must be diluted to the required concentrations and used according to indications.
Side effect
Allergic reactions, skin burns, hyperemia and soreness of the skin at the site of application of the compress.
When used externally, it is partially absorbed through the skin and can have a resorptive general toxic effect (suppression of the central nervous system).
Overdose
Causes characteristic alcoholic excitation; in large doses, it inhibits the functions of the central nervous system.
Interaction with other drugs
When used simultaneously with preparations for external use that contain organic compounds, can cause denaturation of protein components.
special instructions
When used externally, ethanol is partially absorbed through the skin and mucous membranes, which must be taken into account when using it in children, pregnant women and during lactation.
Do not use near open flames.
Impact on the ability to drive vehicles and machinery
The drug, used as a solution for external use, does not affect the ability to drive or engage in other potentially dangerous species activities that require increased concentration and speed of psychomotor reactions. With long-term use in large doses, the drug may be absorbed into the systemic bloodstream, which must be taken into account when controlling transport and mechanisms. Release form
Concentrate for preparing a solution for external use 95%.
100 ml in orange glass bottles, sealed with perforated aluminum caps. A self-adhesive label is attached to each bottle. Each bottle, along with instructions for use, is placed in a cardboard pack.
40 bottles with an equal number of instructions for use are placed in a corrugated cardboard box (for hospitals).
5.0, 10.0 and 21.5 liters in polyethylene canisters low pressure. Each canister is supplied with instructions for use (for hospitals).
Best before date
5 years. Do not use after the expiration date.
Storage conditions
At a temperature not exceeding 25 ° C, in a well-closed container, away from fire.
Keep out of the reach of children.
Vacation conditions
Dispensed by prescription.
Marketing authorization holder / Organization receiving consumer complaints
Alliance LLC, 192019, St. Petersburg, st. 2nd Luch, 13, room. 13
Manufacturer
LLC "Armavir Interdistrict Pharmacy Base".
Addresses of production sites:
1) 352900, Krasnodar region, Armavir, st. Tonnelnaya, 24
2) 174360, Novgorod region, Okulovsky municipal district, urban settlement Uglovskoye, village. Berezovka, p. 75 A.
- Ethanol
Find price:
Pharmacotherapeutic group:
- Antimicrobial, antiparasitic and anthelmintic agents
Pharmacological properties:
Pharmacodynamics
Antiseptic. When applied externally, it has an antimicrobial effect. Active against gram-positive and gram-negative bacteria and viruses. Denatures proteins of microorganisms.
Antiseptic activity increases with increasing ethanol concentration.
To disinfect the skin, use a 70% solution, which penetrates into the deeper layers of the epidermis better than 95% and has a tanning effect on the skin and mucous membranes.
When used systemically, it has the ability to cause analgesia and general anesthesia. The cells of the central nervous system are most sensitive to ethanol, especially the cells of the cerebral cortex, on which ethanol causes characteristic alcoholic excitation associated with a weakening of inhibition processes. Then there is also a weakening of excitation processes in the cortex, depression of the spinal cord and medulla oblongata with suppression of the activity of the respiratory center.
It is a solvent for a number of medicines, as well as an extractant for a number of substances contained in medicinal plant materials.
Pharmacokinetics
Ethanol is metabolized in the liver with the participation of the CYP2E1 isoenzyme, of which it is an inducer.
Indications for use:
Treatment of inflammatory skin diseases in the initial stage (furuncle, panaritium, mastitis); treatment of the surgeon's hands (Furbringer, Alfred methods), surgical field (including in persons with hypersensitivity to other antiseptics, in children and during operations on areas with thin skin in adults - in the neck, face).
As a local irritant drug.
For the production of dosage forms for external use, tinctures, extracts.
Conservation of biological material.
Refers to diseases:
- Mastitis
Contraindications:
Hypersensitivity to ethanol.
Directions for use and dosage:
It is used depending on the indications and dosage form.
Side effect:
Allergic reactions, skin burns, hyperemia and soreness of the skin at the site of application of the compress. When applied externally, it is partially absorbed through the skin and mucous membranes and may have a systemic toxic effect (CNS depression).
Interaction with other drugs:
When used simultaneously, it enhances the effect of drugs that have a depressant effect on the central nervous system, cardiovascular system, and respiratory center.
When taken orally with drugs that have an inhibitory effect on the enzyme aldehyde dehydrogenase (which is involved in the metabolism of ethyl alcohol), the concentration of ethanol metabolite, acetaldehyde, increases, causing flushing, nausea, vomiting, general malaise, tachycardia, and decreased blood pressure.
Special instructions and precautions:
Should not be taken orally during drug treatment.
Application in childhood
When used externally, ethanol is partially absorbed through the skin and mucous membranes, which should be taken into account when used in children.
Instructions for medical use
medicine
Ethanol70%
Cethyl pirt 90%
Tradename
Ethyl alcohol 70%
Ethyl alcohol 90%
International nonproprietary name
Dosage form
Liquid 70% and 90%, 50 ml
Compound
1 liter of the drug contains
Description
Colorless, transparent, volatile, flammable liquid with a characteristic alcoholic odor and pungent taste.
Pharmacotherapeutic group
Other antiseptics and disinfectants. Ethanol.
ATX code D08AX08
Pharmacological properties
The local and reflex action of ethanol consists of irritant, astringent and antiseptic effects. After exposure to skin concentrated solutions of ethyl alcohol (70% and 90%) produce an astringent effect due to the denaturation of protein tissues. The tanning effect of alcohol on the skin reduces its sensitivity and sweating, promoting analgesia and stopping itching.
The antiseptic effect is associated with the denaturation of cytoplasmic and membrane proteins of microbial cells. The bacterial flora is most sensitive to ethanol. The most optimal concentration for the bactericidal effect of the drug is 70%. At higher concentrations, the tanning (astringent) effect of alcohol on tissue structures complicates its diffusion, and the depth of the antiseptic effect decreases.
Indications for use
IN medical practice Ethyl alcohol is used primarily as an external antiseptic and irritant for rubdowns and compresses.
Treatment of the surgeon's hands, surgical field, and medical instruments.
Directions for use and doses
Externally - applied to the skin using cotton swabs or napkins. They make compresses.
Allergic reactions
Irritation and burns of the skin, mucous membranes and respiratory tract
May have a resorptive general toxic effect
CNS depression
Contraindications
Hypersensitivity to the drug
Drug interactions
When taken orally, it potentiates the effect of drugs that depress the central nervous system.
special instructions
For compresses (to avoid burns), ethanol should be diluted with water in a ratio of 1: 1 (70%, 90%).
Pregnancy and lactation
Use with caution
Childhood
It is possible to use in children for compresses in a dilution of 1: 4 (alcohol and water) - for a 90% solution, 1: 3 (alcohol and water) - for a 70% solution.
To sterilize surgical instruments, undiluted 95% alcohol is used.
Overdose
