The drug is available with a doctor's prescription.
TRADE NAMES
Cordanum.DRUG FORM
Film-coated tablets.IN WHAT CASES IS A MEDICINE PRESCRIBED?
For treatment coronary disease heart, angina pectoris.For the treatment of arterial hypertension, hypertensive crisis, vegetative-vascular dystonia By hypertensive type.
For the treatment and prevention of myocardial infarction, disorders heart rate(sinus tachycardia, paroxysmal atrial tachycardia, supraventricular and ventricular extrasystole and tachycardia, atrial fibrillation, atrial flutter).
For the treatment and prevention of pheochromocytoma (as part of complex therapy together with α-adrenergic blockers), thyrotoxicosis, migraine.
With withdrawal syndrome.
APPLICATION OF THE DRUG
ADMISSION RULESThe drug is taken orally, before meals, without chewing.
The initial dose is 100 mg 1-2 times a day. If necessary, the dose is increased by 50 mg, after a week to 300 mg/day.
DURATION OF ADMISSION
The course of treatment is long (from several months to several years). You should not change the dose or stop taking the drug yourself! In case of planned withdrawal, the dose is reduced gradually, by a quarter of the dose every 3-4 days. If the patient's condition has not changed or worsened during treatment, the doctor should be informed.
IF A DOSE IS MISSED
If you miss a dose, take the tablet as soon as you remember. If it is close to your next pill, skip the dose and take the medicine as usual. You should not take a double dose of the drug. Irregular use of the drug reduces the effectiveness of treatment.
OVERDOSE
When taking more than 300 mg/day, a rare pulse, dizziness, excessive decrease in blood pressure, fainting states, arrhythmia, interruptions in heart function, heart failure, the appearance of a blue tint to the nails or palms, convulsions, difficulty breathing.
You should induce vomiting, take activated charcoal, and consult a doctor immediately.
EFFECTIVE AND SAFE TREATMENT
CONTRAINDICATIONSIndividual intolerance. Cardiogenic shock, pulse less than 50 per minute, acute or decompensated heart failure, Prinzmetal's angina. Reduced blood pressure. Bronchial asthma. Diabetes mellitus type 1. Chronic obstructive disease lungs with severe bronchial obstruction. Poor peripheral circulation, intermittent claudication. Concomitant use of monoamine oxidase inhibitors. Pregnancy, breastfeeding.
SIDE EFFECTS
Frequent: weakness, dizziness, headache, drowsiness or insomnia, nightmares, depression, anxiety, blurred vision, dry and painful eyes, conjunctivitis, dry mouth, nausea, vomiting, abdominal pain, constipation or diarrhea, change in taste.
Rare: confusion or short-term memory loss, hallucinations, decreased ability to concentrate, decreased reaction speed, allergic reactions (rash, itching, burning, swelling of the skin), nasal congestion, increased sweating, exacerbation of psoriasis symptoms, back and joint pain, weakened libido, decreased potency, withdrawal syndrome (increased angina attacks), decreased number of cells in the blood.
YOU MUST TELL YOUR DOCTOR
If you suffer from diabetes mellitus, liver disease (hepatitis, cirrhosis), kidney disease or gastrointestinal tract disease.
You are taking any other medications, including medicines over-the-counter herbs and dietary supplements.
Was allergic reaction for any medicine.
When conducting surgical interventions The anesthesiologist should be informed about taking the drug.
Have you ever experienced a decrease in heart rate to 50 beats per minute or less.
If you are pregnant
The drug is contraindicated.
If you are breastfeeding
The drug is contraindicated.
If you suffer from other diseases
For chronic renal failure the dose of the drug should be reduced.
If you drive a car or work with machinery
During the treatment period, it is necessary to refrain from potentially active activities dangerous species activities that require increased concentration and speed of psychomotor reactions, including driving.
If you are over 60 years old
Develop more often side effects, the dose of the drug should be reduced (initial dose - 50 mg 1-2 times a day).
If you are giving the drug to children
The drug should be used only as prescribed by a pediatrician! Discuss possible positive and negative effects with your doctor.
INTERACTIONS
Use with other medications
The effect of the drug is weakened by anti-inflammatory drugs (especially indomethacin), α-adrenergic agonists, and estrogens.
Amiodarone, verapamil, lidocaine and cardiac glycosides increase the risk of side effects.
Diuretics, clonidine, adrenergic blockers, hydralazine, amiodarone can lead to excessive reduction blood pressure.
The drug changes the effectiveness of insulin and hypoglycemic drugs(Blood glucose levels must be carefully monitored).
Alcohol
You should not drink alcohol during treatment with the drug!
STORAGE RULES
Should be stored at room temperature, in a dry, dark place out of reach of children.
Description of the active component
pharmachologic effect
Selective β 1 -adrenergic receptor blocker without intrinsic sympathomimetic activity. In very high doses it can block β 2 -adrenergic receptors. Does not have membrane stabilizing properties. Has antianginal, antihypertensive and antiarrhythmic effect. Reduces catecholamine-stimulated formation of cAMP from ATP, reduces intracellular calcium current, reduces heart rate, inhibits conductivity, and reduces myocardial contractility. In the first 24 hours after the first dose, there is a decrease in minute blood volume and a reactive increase in peripheral vascular resistance, the severity of the latter gradually decreases within 1-3 days.
The antianginal effect is due to a decrease in myocardial oxygen demand as a result of a decrease in heart rate and decreased contractility. A decrease in heart rate leads to prolongation of diastole and improvement of myocardial perfusion. By increasing end-diastolic pressure in the left ventricle and increasing the stretch of ventricular muscle fibers, it can increase oxygen demand, especially in patients with chronic heart failure.
The hypotensive effect is due to inhibition of presynaptic beta-adrenergic receptors of neuron terminals, as well as a decrease in the activity of the renin-angiotensin system; stabilizes by the end of 2 weeks of treatment.
The antiarrhythmic effect is determined by the inhibition of impulse conduction in the antegrade and, to a lesser extent, in the retrograde directions through the AV node and along additional pathways. Reduces the concentration of norepinephrine, prevents increased renin synthesis, interrupting the mutual activation of the renin-angiotensin-aldosterone and sympathoadrenal systems. Reduces mortality and relapse rates in acute myocardial infarction by reducing the area of necrosis and the incidence of rhythm disturbances.
When used in average therapeutic doses, it has a less pronounced effect on the smooth muscles of the bronchi and peripheral arteries and on lipid metabolism than non-selective beta blockers. The onset of the effect is 2-4 hours, duration is up to 24 hours.
Indications
IHD, angina pectoris, myocardial infarction (including secondary prevention); arterial hypertension, hypertensive crisis (hyperkinetic variant); rhythm disturbances (including during general anesthesia, prolapse mitral valve, congenital syndrome prolonged QT interval, myocardial infarction without signs of heart failure, thyrotoxicosis): sinus tachycardia, paroxysmal atrial tachycardia, supraventricular and ventricular extrasystole, supraventricular tachycardia; pheochromocytoma (only with alpha-blockers); withdrawal syndrome, migraine (prevention), tremor; hyperkinetic cardiac syndrome of functional origin.
Dosage regimen
They are set individually, depending on the indications and severity of the disease. When taken orally, the daily dose is 50-300 mg, the frequency of administration is 1-2 times a day.
With intravenous administration single dose- 10 mg, frequency of administration depends on the clinical situation.
Maximum doses: when taken orally - 300 mg/day, when administered intravenously - 60 mg/day.
Side effect
From the outside nervous system: anxiety, weakness, dizziness, headache, drowsiness or insomnia, nightmares, depression, restlessness, confusion, hallucinations, decreased ability to concentrate, decreased reaction speed, paresthesia in the limbs (in patients with intermittent claudication and Raynaud's syndrome), myasthenia gravis (usually an intensification of an existing one), convulsions.
From the senses: blurred vision, decreased secretion of tear fluid, dry and sore eyes, conjunctivitis.
From the outside of cardio-vascular system: bradycardia, palpitations, myocardial conduction disturbances, AV block (up to cardiac arrest), arrhythmias, weakening of myocardial contractility, development (worsening) of chronic heart failure, orthostatic hypotension, manifestations of vasospasm (cold snap) lower limbs, Raynaud's syndrome), chest pain.
From the outside digestive system: dry mouth, nausea, vomiting, abdominal pain, constipation or diarrhea, changes in taste.
From the outside respiratory system: nasal congestion, difficulty breathing when prescribed in high doses (loss of selectivity) and/or in predisposed patients - laryngo- and bronchospasm.
From the outside endocrine system: hyperglycemia (in patients with non-insulin-dependent diabetes mellitus), hypoglycemia (in patients receiving insulin).
Dermatological reactions: increased sweating, skin hyperemia, exacerbation of psoriasis symptoms, psoriasis-like skin rashes, reversible alopecia.
From the hematopoietic system: thrombocytopenia (unusual bleeding and hemorrhage), agranulocytosis, leukopenia.
Other: pain in chest, weakened libido, decreased potency, withdrawal syndrome (increased angina attacks, increased blood pressure).
Contraindications
Cardiogenic shock, AV block II-III stage, severe bradycardia (heart rate less than 40 beats/min), SSSU, sinoatrial block, AV block II-III stage, acute heart failure or decompensated chronic heart failure, cardiomegaly without signs of heart failure , acute heart attack myocardium (complicated by bradycardia, arterial hypotension or left ventricular failure), Prinzmetal's angina, pheochromocytoma (without simultaneous use of alpha-blockers), arterial hypotension (if used for myocardial infarction, systolic blood pressure less than 100 mm Hg), simultaneous use of MAO inhibitors (except for MAO type B inhibitors), lactation period, increased sensitivity to talinolol.
Pregnancy and lactation
The use of talinolol during pregnancy is possible only for health reasons.
It should be borne in mind that talinolol can cause hypoglycemia, bradycardia, and intrauterine growth retardation in the fetus.
If necessary, use of talinolol during lactation breast-feeding should be stopped.
Use for liver dysfunction
Use with caution in case of liver failure.
Use for renal impairment
Use with caution in chronic renal failure.
Use in old age
Use with caution in people over 60 years of age.
Application for children
Use with caution in people under 18 years of age (efficacy and safety have not been determined).
special instructions
Use with caution in diabetes mellitus (especially labile course), metabolic acidosis, COPD (including bronchial asthma, emphysema); AV block of the first degree, chronic heart failure (compensated), obliterating diseases peripheral vessels(intermittent claudication, Raynaud's syndrome); with liver failure, chronic renal failure, with myasthenia gravis, thyrotoxicosis, depression (including a history), with psoriasis, age under 18 years (efficacy and safety have not been determined), age over 60 years.
Treatment should be stopped gradually, over 1-2 weeks, to avoid the development of withdrawal syndrome.
When drinking alcohol during therapy with talinolol, the speed of psychomotor reactions may slow down, associated with a decrease in blood pressure.
Impact on the ability to drive vehicles and operate machinery
When using talinolol, especially at the beginning of treatment and when changing the drug, a slowdown in the speed of psychomotor reactions associated with a decrease in blood pressure is possible. This should be taken into account by patients engaged in potentially hazardous activities that require increased attention and speed of psychomotor reactions.
Drug interactions
When used simultaneously with antihypertensive drugs, the hypotensive effect is enhanced.
With simultaneous use, it is possible to enhance the effect of hypoglycemic, psychotropic drugs and ethanol.
With simultaneous use, the negative chronotropic and dromotropic effects of cardiac glycosides are enhanced; The cardiodepressive effects of class I A antiarrhythmic drugs are enhanced.
When used simultaneously with ergot alkaloids (especially non-hydrogenated ones), the risk of developing peripheral circulatory disorders increases.
When used simultaneously with verapamil, diltiazem (especially IV forms), the cardiodepressive effect of talinolol may be enhanced.
In patients receiving beta-blockers, severe arterial hypertension may develop if clonidine is suddenly discontinued. It is believed that this is due to an increase in the content of catecholamines in the circulating blood and an increase in their vasoconstrictor effect.
When used simultaneously with reserpine and methyldioxyphenylalanine, bradycardia may increase.
When used simultaneously with sulfasalazine, a significant decrease in the concentration of talinolol in the blood was observed.
When used simultaneously with erythromycin, it is possible to increase the concentration of talinolol in the blood plasma.
Talinolol INN
Description active substance(INN) Talinolol.
Pharmacology: pharmachologic effect - hypotensive, antianginal, antiarrhythmic . Selectively blocks beta1-adrenergic receptors of the heart.
Indications: IHD: angina pectoris (tension, unstable), acute myocardial infarction (treatment and prevention); arterial hypertension, diastolic heart failure, supraventricular and ventricular extrasystole, paroxysmal tachycardia, atrial flutter and fibrillation, hyperkinetic cardiac syndrome, neurocirculatory dystonia of the hypertensive type.
Contraindications: Hypersensitivity, cardiogenic shock, severe bradycardia (less than 50 beats/min), AV disorders (II-III degrees) and sinoauricular conduction, sick sinus syndrome, heart failure (III-IV NYHA degrees) with a significant decrease in systolic function of the left ventricle, acute myocardial infarction with complications (bradycardia, hypotension, left ventricular failure), severe hypotension, bronchial asthma, diabetes(decompensated form), breastfeeding.
Restrictions on use: Obstructive pulmonary diseases, impaired renal function, severe disorders of the peripheral arterial circulation, Prinzmetal's angina, AV block of the first degree, pheochromocytoma, labile diabetes mellitus, metabolic acidosis, aggravated allergic history, psoriasis, elderly (over 60 years old) and childhood(safety and effectiveness in children have not been determined).
Use during pregnancy and breastfeeding: Possible if the expected effect of therapy exceeds the potential risk to the fetus. Breastfeeding should be stopped during treatment.
Side effects: From the nervous system and sensory organs: dizziness, headache, drowsiness, lethargy, sleep disorders, visual impairment, rarely - depression, hallucinations, psychosis; decreased secretion of tear fluid, hearing impairment.
From the cardiovascular system and blood (hematopoiesis, hemostasis): sinus bradycardia, AV block, hypotension, rarely - impaired peripheral circulation (cold extremities).
From the gastrointestinal tract: dyspeptic symptoms, abdominal pain, hypoglycemia, cholestatic hepatosis (extremely rare).
Other: bronchospasm, convulsions, weight gain, decreased potency, alopecia, exanthema, hyperhidrosis, feeling of heat.
Interaction: Calcium antagonists (dihydropyridine derivatives) increase antianginal and hypotensive activity, but with intravenous administration they increase the likelihood of disturbances in myocardial conduction and contractility; ergotamine can increase peripheral circulatory disorders. Potentiates the negative chrono- and dromotropic effect of cardiac glycosides and antiarrhythmic drugs class IA, peripheral muscle relaxants. When combined with MAO inhibitors, arterial hypertension may develop during therapy and within 14 days after their discontinuation. NSAIDs weaken their antihypertensive properties (suppress PG synthesis in the kidneys and retain sodium and water). Sulfasalazine reduces plasma concentration, H2 blockers increase (block hepatic biotransformation). Against the background of reserpine, clonidine, methyldopa, additive excessive beta-adrenergic blockade is possible; beta-adrenergic agonists and methylxanthines - mutual suppression of action; phenothiazine - increased plasma concentrations of both drugs. Strengthens the inhibitory effect of alcohol and psychotropic drugs on the central nervous system, reduces theophylline Cl.
Overdose: Symptoms: nausea, vomiting, a sharp decline Blood pressure with a weakened response to catecholamines (develops 30-240 minutes after the last dose), severe bradycardia, conduction disturbances, weakened cardiac contractility, intraventricular conduction disturbances, central nervous system depression (apathy, drowsiness, coma), convulsions, hypoxia, bronchospasm.
Treatment: gastric lavage, appointment activated carbon and sodium sulfate, stabilization of acid-rich hormone and electrolyte balance, oxygen therapy; maintaining cardiac activity (isadrin 1-4 mg IV bolus, then infusion 10 mg/100 ml; dobutamine 50-100 mcg, then infusion 300 mcg/100 ml; dopamine 0.25-0.4 mg/min, then 250 mg/100 ml; glucagon 5-10 mg for 5 minutes, then infusion 1-5 mg/h); administration of atropine (IV, infusion, 0.5-2 mg over 8 hours), aminophylline IV 4-6 mg/kg for bronchospasm, diazepam (5-10 mg IV to relieve seizures). Temporary use possible artificial driver rhythm. Hemodialysis and hemoperfusion are ineffective.
Method of administration and dosage: Orally, 0.5-1 hour before meals, without chewing and with a small amount of liquid, intravenously (previously diluted with isotonic sodium chloride solution in a ratio of 1:1) slowly in a stream or by intravenous drip infusion . For arterial hypertension, hyperkinetic syndrome, neurocirculatory dystonia of the hypertensive type and stable angina - orally, 50 mg 1-2 times a day (morning and evening) or 100 mg once; if necessary, up to 300 mg/day. The maximum daily dose is 400-600 mg. For acute rhythm disturbances - IV 10 mg at a rate of 2 ml/min, possibly again after 10 minutes. The maximum daily dose is 60 mg. In acute myocardial infarction, severe unstable angina on the first day, it is administered intravenously at a dose of 10-20 mg/hour, the daily dose is 50 mg; on the second day the dose is reduced by half, then orally at a dose of 100-200 mg. The maximum daily dose is 300 mg.
Precautions: Cancellation should be carried out gradually (withdrawal syndrome is likely). In patients with a burdened allergic history, the severity of the hypersensitivity reaction may increase and the absence of therapeutic effect from normal doses of adrenaline. To terminate simultaneous treatment with clonidine, talinolol is discontinued gradually, several days before clonidine is discontinued, due to the risk of developing a severe hypertensive crisis. In case of heart failure, to prevent the initial weakening of myocardial contractility and a decrease in blood pressure, it is necessary to begin treatment with very small doses (1/4 of the minimum therapeutic dose) followed by a slow increase. When administered intravenously, ECG monitoring is recommended. Weakens compensatory cardiovascular reactions in response to the use of general anesthetics. Talinolol should be discontinued before surgical intervention under general anesthesia, performing cardiac catheterization with selective coronary angiography.
It is necessary to control blood glucose levels in patients with labile diabetes mellitus and hyperglycemia. Patients with diabetes mellitus should be informed that the main sign of hypoglycemia during treatment is increased sweating. After prolonged fasting and heavy physical activity, it can cause hypoglycemia.
When prescribed during pregnancy, discontinue use 2-3 days before birth (risk of bradycardia, hypotension and hypoglycemia in the newborn). Use with caution when working for drivers Vehicle and people whose profession is associated with increased concentration. It is recommended to avoid alcohol intake during treatment.
Talinolol (Talinololum)pharmachologic effect
Cardioselective (selectively acting on beta-adrenergic structures of the heart) beta-blocker. It has a moderate negative inotropic and chronotropic effect on the heart (reduces the strength and frequency of heart contractions), does not affect bronchial beta2-adrenergic receptors. It has a hypotensive (blood pressure-lowering) effect without causing orthostatic hypotension (a drop in blood pressure when moving from horizontal to vertical position). Has an antiarrhythmic effect in sinus tachycardia(rapid heartbeat) and with supraventricular and ventricular cardiac arrhythmias.Indications for use
Prescribed for angina pectoris, arterial hypertension (increased blood pressure), heart rhythm disturbances (supraventricular and ventricular extrasystole, paroxysmal tachycardia, atrial flutter and fibrillation, ventricular tachycardia).Mode of application
Take orally, starting from 0.05 g (1 tablet 3 times a day). If necessary, increase the dose to 2 tablets 3 times a day. The maximum daily dose is 400-600 mg.Side effects
Possible side effects: feeling of heat, dizziness, nausea, vomiting.Contraindications
Atrioventricular block II-III degree (impaired transmission of impulses through the conduction system of the heart), bradycardia, arterial hypotension, acute and chronic heart failure. Caution should be exercised when prescribing the drug to pregnant women.Release form
Dragee 0.05 g (50 mg) in a package of 50 pieces.Storage conditions
List B. Under normal conditions.Synonyms
Cordanum.Active substance:
talinololAuthors
Links
- Official instructions for the drug Talinolol.
- Modern medications: a complete practical guide. Moscow, 2000. S. A. Kryzhanovsky, M. B. Vititnova.
Description of the drug " Talinolol"on this page is a simplified and expanded version official instructions by application. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
|
Talinolol Analogues
Cordanum
Recipe (international)
Rp.: Dr. "Talinolol" 0.005 No. 10
D.S. Take 1 dr. orally 3 times a day.
pharmachologic effect
Pharmacological action - antianginal, hypotensive, antiarrhythmic.
Selectively blocks beta1-adrenergic receptors of the heart. Reduces the automatism of the sinus node, exhibits moderate negative chrono-, ino- and dromotropic activity, and normalizes the baroreflex response. Lowers blood pressure (the hypotensive effect reaches a maximum after 5 hours, lasts 24 hours and stabilizes in the 2nd week of treatment).
Reduces myocardial oxygen demand, the severity of left ventricular diastolic dysfunction, increases tolerance to physical activity. Reduces the level of plasma norepinephrine, eliminates hyperactivation of the sympathoadrenal system: dysfunction and death of cardiomyocytes (necrosis and apoptosis), deterioration of hemodynamics, decrease in the density and affinity of beta-adrenergic receptors, chronic tachycardia, myocardial hypertrophy, induction of myocardial ischemia (due to tachycardia, myocardial hypertrophy and vasoconstriction) and provocation of arrhythmias. By reducing the level of norepinephrine, it prevents increased renin synthesis and breaks the “vicious circle” of mutual activation of the renin-angiotensin-aldosterone and sympathoadrenal systems. In acute myocardial infarction, it reduces mortality and the frequency of relapses by reducing the ischemic zone and the frequency of rhythm disturbances. Does not have a negative effect on lipid metabolism.
Mode of application
For adults: Take orally, starting from 0.05 g (1 tablet) 3 times a day (before meals). If necessary, increase the dose to 2 tablets 3 times a day. For severe unstable angina, 10 mg is administered intravenously slowly.
If the effect is insufficient, after 10 minutes the administration of the drug can be repeated at the same dose. In these patients, talinolol can also be used as an intravenous drip infusion at a total dose of 30-60 mg per 200 ml of isotonic sodium chloride solution for 24 hours.
In case of acute myocardial infarction, it is prescribed from the first day of the disease - intravenously 10-20 mg/hour; total dose up to 50 mg. On the second day - intravenously at a dose of 50% of the dose of the first day.
You can prescribe the drug re ros (by mouth) in daily dose 100-200 mg (up to 300 mg).
For secondary prevention of myocardial infarction, 100-200 mg per os in 1 or 2 doses. Start treatment only on the recommendation of a doctor.
Indications
IHD: angina (tension, unstable)
- acute myocardial infarction (treatment and prevention);
- arterial hypertension, diastolic heart failure, supraventricular and ventricular extrasystole, paroxysmal tachycardia, atrial flutter and fibrillation, hyperkinetic cardiac syndrome, neurocirculatory dystonia of the hypertensive type
Contraindications
Hypersensitivity
- cardiogenic shock
- severe bradycardia (less than 50 beats/min)
- disturbances of AV (II–III degree) and sinoauricular conduction
- sick sinus syndrome
- heart failure (NYHA grade III–IV) with a significant decrease in left ventricular systolic function
- acute myocardial infarction with complications (bradycardia, hypotension, left ventricular failure)
- severe hypotension
- bronchial asthma
- diabetes mellitus (decompensated form)
- lactation.
Side effects
From the nervous system and sensory organs: dizziness, headache, drowsiness, lethargy, sleep disorders, visual impairment, rarely - depression, hallucinations, psychosis; decreased secretion of tear fluid, hearing impairment.
- From the cardiovascular system and blood (hematopoiesis, hemostasis): sinus bradycardia, AV block, hypotension, rarely - impaired peripheral circulation (cold extremities).
- From the gastrointestinal tract: dyspeptic symptoms, abdominal pain, hypoglycemia, cholestatic hepatosis (extremely rare).
- Other: bronchospasm, convulsions, weight gain, decreased potency, alopecia, exanthema, hyperhidrosis, feeling of heat.
Release form
Dragees of 0.005 and 0.1 g (50 and 100 mg) in a package of 10 pieces; ampoules of 5 ml containing 10 mg of the drug, in a package of 10 pieces.
ATTENTION!
The information on the page you are viewing is created for informational purposes only and does not in any way promote self-medication. The resource is intended to provide healthcare workers with additional information about certain medications, thereby increasing their level of professionalism. Use of the drug "" in mandatory involves consultation with a specialist, as well as his recommendations on the method of use and dosage of the medicine you have chosen.
