The medicine gel Lyoton-1000 received wide application in the treatment of conditions associated with rapid blood clotting. It is used in therapy, to remove bruises and bruises, and to prevent the formation of blood clots.
How does the drug work when various states and how to apply it correctly in practice?
General information
Lyoton-1000 has proven its effectiveness in the prevention of blood clots, in the fight against and in the treatment of conditions of rapid blood clottingThe action of the drug is based on the substance “heparin”, which is part of its composition, which is normally excreted by the kidneys in the human body. Active substance prevents the formation of blood clots and, when entering the human blood, accelerates the effect of the protein against rapid blood clotting.
Penetrating through the skin, heparin spreads through the blood and organs and has the following effects on the body:
- Increases blood flow in the kidneys;
- Prevents the formation of blood clots;
- Reduces the risk of blood clots;
- Eliminates growths on the skin;
- Increases vascular resistance;
- Reduces the risk of occurrence.
The ointment is not quickly absorbed into the skin - after applying the gel, heparin enters the bloodstream only after 8 hours. After that active substance remains in the body for another 24 hours, after which it is excreted in the urine.
Important! For pregnant and nursing mothers, it is very important that the gel is excreted along with urine, without passing into breast milk.
Application of the gel:
- Prevention and treatment;
- Edema of the lower extremities;
- Injuries, fractures, bruises, sprains;
- Phlebeurysm, spider veins on the face and legs;;
- Tumors and lumps on the extremities of a non-infectious nature;
- Complications of vein operations;
- Formation of hematomas under the skin (bruises).
Lyoton-1000 gel is often used as an analgesic that can relieve pain in the legs when standing and walking, heaviness and fatigue in the lower extremities, and itching in the blood vessels.
Directions for use and dosage
The course and duration of treatment should be determined strictly by the doctor, while the gel itself is used only externally (i.e. on open wounds It is strictly prohibited to apply it) The gel is used only externally - it is applied to damaged areas of the body as prescribed by a doctor, who determines the dosage of the drug and the duration of the course of treatment.
Application of Lyoton gel according to the instructions:
- For abrasions and bruises– apply the drug in a circular, gentle motion to the damaged area of the skin;
- For open wounds and ulcers– the medicine is applied to the skin around the wound;
- At– the gel is applied to a bandage, which is placed on the damaged area;
- At– a cotton swab is dipped into the gel and then placed in the anus.
Typically, the drug is applied in a layer of one to three centimeters about three times a day. The drug is quickly absorbed and therefore does not leave greasy stains on clothes, which makes it very convenient to use.
When using Lyoton gel, the course of treatment can last from one to four weeks, depending on the diagnosis:
- For injuries, bruises and swelling the gel is applied until the damage completely disappears 1-3 times a day;
- For varicose veins (initial stage diseases), for burning in the veins, heaviness in the legs, to eliminate the vascular network, the drug is used for one to three weeks.
- For chronic venous insufficiency you should use the gel for at least a month (in some cases – up to 6 months).
The drug most often does not cause side effects. Only too long use of the gel can cause some allergic reactions in the form of redness, itching and excessive dryness skin. If they appear, it is necessary to stop using the drug and eliminate the negative effects with the help of regenerating lotions and creams.
Cases of overdose when using the gel were not observed, because it cannot be applied too much due to the low absorption of the drug.
Important! If the gel accidentally gets on your mucous membranes, you should immediately rinse them with water. If a child accidentally ingests the gel, he should quickly induce vomiting and rinse the stomach.
You cannot use Lyoton gel:
- In case of intolerance or allergy to the components of the drug;
- If there are existing blood clotting disorders;
- For diseases that cause heavy bleeding;
- In the presence of purulent processes;
- During menstruation;
- When threatened;
- In the treatment of phlebitis;
- After recent operations on the brain, eyes, bile ducts.
Lyoton gel can be used during pregnancy only with the permission of a doctor, because There are cases of spontaneous after using the drug.
Note! The gel cannot be used if the integrity of the skin is damaged - on open ulcers, wounds.
The medicine is often used in complex therapy in the treatment of varicose pathologies. Therefore, you should consult your doctor before using it - if other drugs that affect the state of the blood (, etc.) are used at the same time, then heavy bleeding is possible.
How can I replace Lyoton gel?
Lyoton-1000 does not cost too little, so searching for analogues is a completely reasonable solution, but the main thing is not to forget about real reviews Gel Lyoton has a lot of advantages - it acts quickly, short time shows effectiveness, has practically no side effects and contraindications. But some patients have doubts about using the drug when they find out how much it costs.
Average price (Moscow):
- Tube 30 g – 300-400 rubles;
- Tube 50 g – 400-460 rubles;
- Tube 100 g - about 600-700 rubles.
From inexpensive analogues Lyoton there are domestically produced drugs: Heparin ointment, Heparin, Heparin-Acrigel. For example, heparin ointment can be bought much cheaper (from only 35 rubles), but it has a number of disadvantages compared to Lyoton: the ointment cannot be used on the face and it is poorly absorbed and leaves marks on clothes.
Structural analogues of Lyoton: Trombless, Heparin-Acrigel-1000, Laventum.
Substitutes similar in mechanism of action: Dolobene, Venolife, Contratubeks.
It is difficult to determine how effective analogs of the drug are compared to the Lyoton gel itself, because each medicine is selected for the treatment of a specific disease on an individual basis. Therefore, the decision to prescribe the drug should be entrusted to the doctor.
- a proven remedy for varicose veins, and it also helps prevent blood clots and removes bruises. Since the product contains heparin, it perfectly eliminates inflammation and pain, thins the blood and prevents the formation of clots.
Composition and pharmacological action of Lyoton gel
In addition to sodium heparin, the gel contains:
- Lavender oil and triethanolamine;
- Carbomer 940 and neroli oil;
- Methyl parahydroxybenzoate and propyl parahydroxybenzoate;
- Water.
The drug gel Lyoton 1000 helps relieve swelling, reduces vascular permeability and relieves inflammatory process. When applied to the skin after 8 hours the contents active ingredients reaches its maximum in the blood.
Fully therapeutic effect decreases only after 24 hours, and the excretion and breakdown of heparin is controlled by the kidneys. Available in an aluminum tube weighing 30 g. cost 320 rubles. Available in tubes of 50 and 100 g. Made in Germany.
Indications for use
Most often, the gel is used after vein surgery and to prevent complications such as thrombosis.
In addition, indications for use will be:
- Injuries and sprains, localized swelling;
- Spider veins on the legs and face;
- Bruises and bruises of various types;
- Subcutaneous hematomas, inflammation with infiltrate.
What other symptoms will Lyoton cure and eliminate: fatigue and heaviness in the legs, itching in the vascular wall, painful sensations in the legs when walking and standing.
Contraindications
Although Lyoton gel is considered a rather mild product, it also has its contraindications. For example: intolerance to the components, and it cannot be used in cases of violation of the integrity of the skin, ulcers and necrosis.
Do not use the gel for thrombocytopenia and reduced hemocoagulation, deep vein thrombosis. By-effect– possible redness and slight itching of the skin. When you stop using Lyoton, the symptoms will disappear.
Instructions for use
Most often, the gel is prescribed by a doctor, but you can purchase it yourself if you have problems with leg swelling and varicose veins. The product is sold in pharmacies without a prescription.
Also prescribed for:
- Thrombophlebitis and periphlebitis;
- For vascular injuries and hematomas;
- Varicose veins and chronic venous insufficiency;
- For bruises, bruises, swelling;
- After vascular operations;
- As a prophylactic.
Make sure you have no contraindications to application and apply sore spot in a circular motion. A single dosage of the product is from 1-3 cm. You can use this product up to 3 times a day. The gel is quickly absorbed and does not leave greasy marks on clothes, so it is very convenient to use.
On average, the use of the drug can be prescribed from one week to a month, depending on the diagnosis. Can be used for swelling of the legs during pregnancy, but be sure to consult your doctor about this
When treating bruises or abrasions, it is better to apply the gel to a sterile bandage and fix it. When treating an ulcer, do not apply the product to the surface; treat the skin around it. Doctors often prescribe the use of Lyoton for hemorrhoids, for which they treat a tampon with it and insert it into the rectum.
For varicose veins, the product is used from 1 to 3 weeks, for chronic venous insufficiency up to six months.
The drug should not be combined with medications:
- Tetracycline and antihistamines;
- Non-steroidal anti-inflammatory drugs.
Analogs Lyoton 1000
Since the product contains heparin, it has many analogues, for example:
Similar by chemical composition facilities:
- Hepatrombin and Heparin ointment;
- Heparin Acrigel 1000;
- Heparin, Trombless and Laventum.
In another article you will find even more information about.
Therapeutic effects are the same as the gel:
- Heparin ointment and Venitan forte;
- Venolife and Hepatrombin;
- Dolobene and Troxevasin NEO
Some analogues are quite expensive, others, like Heparin ointment- cost pennies. But we must not forget that the ointment cannot be used on the face, and it is also very poorly absorbed, so it should not be applied under clothing. While the gel is a convenient form that allows you to use it at any time for any purpose, right in the office.
Both drugs are Lyoton 1000, so Heparin ointment have anticoagulant properties, but the ointment contains 10 times less heparin than Lyoton. But the ointment contains benzocaine, which acts as an anesthetic. Everyone decides for themselves what suits them best, because both drugs prevent the development of blood clots.
When comparing Troxevasin with Lyoton It can be noted that it has an angioprotective effect, so it will be less effective in eliminating the symptoms of varicose veins.
Trombless considered practically complete analogue Lyoton, and costs an order of magnitude cheaper. Features of Trombless: it has anti-edematous, analgesic and anti-inflammatory functions.
Lyoton ointment is used to relieve symptoms of heaviness in the legs, swelling, and blocked veins. The drug is prescribed as part of complex therapy for the treatment of chronic and acute vascular pathologies. As a mono-medicine, it is effective for swelling and bruising due to soft tissue injury.
An external venotonic agent is available in aluminum tubes with a volume of 30-50-100 g.
The main component of the ointment is sodium heparin. The substance content in 1 g corresponds to 1000 IU. Lyoton has a jelly-like, yellowish consistency that is easily absorbed into the skin.
Properties of Heparin - reducing blood viscosity, restoring connective tissue.
For external use:
- has a restorative effect on subcutaneous traumatic hemorrhages (bruises, hematomas);
- promotes the dissolution of blood clots;
- increases capillary permeability;
- prevents blood thickening during venous stagnation.
Additional ingredients in Lyoton:
- parabens (methyl-, propyl-);
- Carbomer;
- ethanol:
- water;
- lavender oil, neroli;
- Triethanolamine.
Methyl parahydroxybenzoate and Propyl parahydroxybenzoate are preservatives, Carbomer gives the ointment viscosity, Triethanolamine is an oil emulsifier. The aroma of lavender and neroli oils neutralize the specific smell of benzoic acid and Heparin preparations.
Indications for use
Lyoton 1000 is useful for prolonged static loads on lower limbs, which is associated with the performance of professional duties: sedentary work while standing, lifting heavy objects. Hereditary weak venousness (insufficient functioning of the venous valves) is also compensated by the use of the drug Lyoton.
Attention! The ointment is used as part of complex therapy for vascular pathologies as a symptomatic remedy to relieve pain.
What it helps with:
- with thrombosis with inflammation of superficial venous vessels;
- varicose veins of the legs;
- inflammation vascular walls(periphlebitis);
- phlebothrombosis (formation of blood clots in the venous bed);
- swelling after a bone fracture, dislocation, sprain;
- superficial hematomas;
- mastitis;
- after vein operations;
- soft tissue bruises with bruising;
- infected seals.
The composition is applied to clean, dry skin. The individual duration and frequency of administration should be determined by the doctor.
Average values for ointment use (depending on the disease, the degree of vascular damage):
- treatment of injuries, bruises - until the bruise completely resolves;
- relief of symptoms of venous insufficiency – 21 days, repeated course in a month;
- restoration of blood flow during thrombosis as part of complex therapy – 30 days, with treatment continued for a year.
The dose of Lyoton in the instructions for use varies from 3 to 10 cm, which depends on the size of the affected area. The ointment is applied in a thin layer and rubbed into the skin with light pressure. Frequency – from 1 to 3 times a day.
The ointment retains its properties at a temperature not exceeding 25 degrees for 5 years when sealed. After opening the tube, you must use the gel within 30 days.
There are no contraindications for breastfeeding.
The drug does not affect concentration and reaction speed when driving a vehicle or high-risk mechanisms.
Keep away from children.
Contraindications and side effects
The gel is not used if the skin is damaged:
- wounds;
- scratches;
- ulcers
It is contraindicated to use Lyoton if there are allergic rashes, infectious nature, for dermatitis, eczema, insect bites.
Lyoton has contraindications:
- with increased bleeding (reduced blood clotting, insufficient number of platelets).
- allergic reaction to the components of the ointment, manifested in the form of itching, rash, swelling;
- cirrhosis, hepatitis;
- pregnancy with the threat of premature birth.
The drug is prescribed with restrictions:
- for bronchial asthma;
- arterial hypertension;
- elevated blood sugar levels;
- inflammation of the heart muscle;
- tuberculosis in the active stage;
- liver, kidney failure;
- patients over 60 years old;
- children;
- during radiotherapy.
Attention! Simultaneous use of other anticoagulants, non-steroidal anti-inflammatory drugs, antiplatelet agents enhances the effect of Lyoton and may cause increased bleeding.
Reduce the effectiveness of the ointment:
- nicotine;
- ergot preparations;
- Thyroxine;
- antihistamines.
External use of the drug has no information about cases of overdose. If Lyoton is swallowed by a child, nausea and vomiting are detected. After gastric lavage, the antidote Protamine sulfate is prescribed in large doses.
Direct acting anticoagulants.
Lyoton composition
The active substance is sodium heparin.
Manufacturers
A.Menarini Manufacturing Logistics and Services S.r.L. (Italy)
pharmachologic effect
Anticoagulant, fibrinolytic, antiaggregant.
The complex with antithrombin III inhibits thrombus formation:
- binds activated factor X and inhibits the conversion of prothrombin to thrombin.
In large doses, it inactivates thrombin and reduces the conversion of fibrinogen to fibrin, preventing the activation of the fibrin-stabilizing factor.
The highest bioavailability is observed with intravenous administration; with subcutaneous administration, bioavailability is low, maximum concentration is achieved after 2-4 hours; half-life is 1-2 hours; in plasma is mainly in a protein-bound state.
In patients with ischemic heart disease (in combination with aspirin) reduces the risk of developing acute thrombosis coronary arteries, myocardial infarction and sudden death.
Reduces the frequency of recurrent infarctions and mortality in patients who have had myocardial infarction.
In high doses it is effective against pulmonary embolisms and venous thrombosis, in small cases - for the prevention of venous thromboembolism, incl. after surgical operations; with intravenous administration, blood coagulation slows down almost immediately, with intramuscular injection - after 15-30 minutes, with subcutaneous administration - after 40-60 minutes, after inhalation the maximum effect is within a day; the duration of the anticoagulation effect is respectively 4-5 hours, 6 hours, 8 hours, 1-2 weeks, the therapeutic effect - prevention of thrombus formation - lasts much longer.
Deficiency of antithrombin III in plasma or at the site of thrombosis may limit the antithrombotic effect of heparin.
Side effects Lyoton
Dizziness, headaches, nausea, anorexia, vomiting, diarrhea, alopecia; early (2-4 days of treatment) and late (autoimmune) thrombocytopenia; hemorrhagic complications- bleeding in the gastrointestinal tract or urinary tract, retroperitoneal hemorrhages in the ovaries, adrenal glands (with the development of acute adrenal insufficiency), osteoporosis, soft tissue calcification, inhibition of aldosterone synthesis, increased levels of transaminases in the blood, allergic reactions (fever, rashes, bronchial asthma, anaphylactoid reaction), local irritation, hematoma, pain upon injection.
Indications for use
Unstable angina, acute heart attack myocardium; thromboembolic complications during myocardial infarction, heart surgery and blood vessels, pulmonary embolism and cerebral vessels, thrombophlebitis; DIC syndrome, prevention of microthrombosis and microcirculation disorders; renal vein thrombosis; hemolytic-uremic syndrome; atrial fibrillation, mitral heart defects; bacterial endocarditis; glomerulonephritis; lupus nephritis; rheumatism; bronchial asthma; carrying out extracorporeal methods (extracorporeal circulation during cardiac surgery, hemosorption, hemodialysis, peritoneal dialysis, cytapheresis), forced diuresis; flushing venous catheters.
Contraindications Lyoton
Increased sensitivity hemorrhagic diathesis, leukemia, anemia, increased vascular permeability, polyps, malignant neoplasms and ulcerative lesions of the gastrointestinal tract, severe violations liver and kidney functions, brain and spine surgeries.
Directions for use and dosage
Encyclopedia of Medicines 2002, issue 9. 2.
Directory "Vidal", 2005
Overdose
Symptoms:
- bleeding varying degrees gravity.
Treatment:
- if there is slight bleeding, reduce the dose or stop using the drug,
- when heavy bleeding A 1% solution of protamine sulfate is slowly injected intravenously.
Interaction
Efficiency is enhanced acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, warfarin, dicoumarin, weakened by cardiac glycosides, tetracyclines, antihistamines, nicotinic acid, ethacrynic acid.
special instructions
Use during pregnancy and breastfeeding is possible only under strict indications.
Constant monitoring of blood clotting time is necessary; withdrawal should be carried out gradually.
Lyoton 1000: instructions for use and reviews
Latin name: Lioton 1000
ATX code: C05BA03
Active substance: heparin sodium (heparinum natricum)
Manufacturer: A. Menarini Manufacturing Logistics and Services S.r.L. (A.Menarini Manufacturing Logistics and Services S.r.L.) (Italy)
Updating the description and photo: 20.08.2019
Lyoton 1000 is an external drug that has an antithrombotic effect.
Release form and composition
Lyoton 1000 is available in the form of a gel for external use: almost transparent, with a slightly yellowish tint, or colorless, viscous consistency (30, 50 or 100 g in aluminum tubes, 1 tube in a cardboard box).
The composition of 1000 mg of gel includes:
- Active substance: sodium heparin – 1000 IU (International Units);
- Excipients: methyl parahydroxybenzoate – 1.2 mg, carbomer 940 – 12.5 mg, propyl parahydroxybenzoate – 0.3 mg, ethyl alcohol 96% (ethanol) – 0.3 ml, neroli oil – 0.5 mg, lavender oil – 0 .5 mg, trolamine (triethanolamine) – 8.5 mg, purified water – up to 1000 mg.
Pharmacological properties
Pharmacodynamics
Heparin sodium is a direct anticoagulant, part of the group of medium molecular heparins. It prevents thrombus formation, enhances the fibrinolytic properties of blood, and inhibits the activity of hyaluronidase.
When used externally, heparin sodium is characterized by local anti-inflammatory, decongestant and antithrombotic effects: the drug reduces tissue swelling, prevents the formation of blood clots, and also activates tissue metabolism and improves blood microcirculation processes, which promotes accelerated resorption of hematomas.
Pharmacokinetics
When applied externally, heparin sodium in small concentrations penetrates the systemic circulation, but does not have systemic action and does not cause any changes in blood clotting parameters. Also, the substance does not cross the placental barrier.
Indications for use
- Phlebothrombosis, thrombophlebitis of superficial veins;
- Complications after surgical operations on veins;
- Bruises, injuries (including joints, muscle tissue and tendons);
- Edema and localized infiltrates;
- Subcutaneous hematomas.
Contraindications
- damage to the skin at the intended site of application of the gel, such as open wound surfaces, ulcerative necrotic ulcerations;
- thrombocytopenia, increased tendency to bleeding;
- age under 18 years;
- proven hypersensitivity to heparin or auxiliary components of the drug.
Instructions for use of Lyoton 1000: method and dosage
Lyoton 1000 is used externally, applying the gel to the affected area and gently rubbing, 1-3 times a day. Single dose– 3-10 cm of gel.
- localized consequences of injuries and bruises (infiltration, hematoma, swelling of soft tissues) - the gel should be used until the symptoms disappear;
- initial symptoms of venous insufficiency (venous edema, heaviness and pain in the legs) - course duration is from 1 to 3 weeks, depending on the severity of symptoms;
- chronic venous insufficiency(superficial periphlebitis, varicose veins veins, superficial thrombophlebitis) – course duration is from 4 to 6 weeks, depending on the severity of symptoms; If further therapy is necessary, consult a doctor.
Side effects
During the use of Lyoton 1000, side effects may develop, manifested in the form of allergic reactions.
Overdose
Due to the very low systemic absorption of heparin sodium, an overdose of Lyoton 1000 at local application considered practically impossible. If undesirable symptoms appear after applying the product to the skin, it is recommended to neutralize the effect of the drug with a solution of protamine sulfate.
special instructions
Gel Lyoton 1000 cannot be used for purulent processes, bleeding, or applied to open wounds and mucous membranes.
Impact on the ability to drive vehicles and complex mechanisms
According to the instructions, Lyoton 1000 does not affect the ability to drive vehicles or perform complex species work that requires increased concentration.
Use during pregnancy and lactation
It is allowed to prescribe Lyoton 1000 during pregnancy and during breastfeeding. Heparin sodium does not cross the placental barrier and is not detected in breast milk. Since this substance is only slightly absorbed when applied externally, the drug does not have a systemic effect on the body. However, pregnant and breastfeeding women should consult a doctor before starting treatment.
