Metrogyl for intravenous infusion. Metrogyl - instructions for use

Metrogyl instructions

Metrogyl has a bactericidal effect on a relatively large number of varieties anaerobic microorganisms. The drug is also used to eliminate some gram-positive and protozoan bacteria.

The active substance is metronidazole, which belongs to the group of nitroimidazole derivatives.

Metrogyl interacts with intracellular bacterial proteins, causing a reduction reaction of the 5-nitro group. As a result, this drug can inhibit the synthesis of certain acids on which bacterial DNA is based. DNA damage causes the death of harmful microorganisms.

The drug is able to act against bacterial infections if they were caused by anaerobic microorganisms.

For the treatment of infectious diseases that were caused by both anaerobic and aerobic microorganisms, a combination of Metrogyl and antibiotics acting against aerobic microorganisms should be used.

It must be remembered that Metronidazole can increase the sensitivity of tumors to radiation. The action of the drug is similar to disulfiram. The medicine also stimulates repair in the body.

After administration, Metrogyl is well absorbed from the gastrointestinal tract. Maximum concentration is observed 2 hours after oral administration active substance in blood plasma. The product is widely distributed throughout organs and tissues.

The drug is mostly excreted by the kidneys, with some excreted through the feces. Regular duration The half-life is 6–8 hours, but liver dysfunction increases this period.

At severe violations renal function, the drug can accumulate with repeated administrations.

Side effects

Sometimes the following appears side effects: hallucinations, convulsions, weakness, excitability, irritability, disturbances in daily routine, confusion, impaired coordination and orientation in space, dizziness, headache. In isolated cases, peripheral nephropathy is noted.

The gastrointestinal tract sometimes reacts with the appearance inflammatory diseases in the throat and oral cavity, metallic taste and dry mouth, vomiting, nausea, anorexia, constipation or diarrhea, pancreatic dysfunction.

In a relationship genitourinary system observed: polyuria, dysuria, vaginal candidiasis, darkening of urine, redness in the perineum, burning, itching.

The hematopoietic system may respond with leukopenia and thrombocytopenia.

You may also experience: allergic rhinitis, anaphylactic shock, increased body temperature, urticaria, itchy skin, redness skin, changes in electrocardiogram readings, neutropenia.

Contraindications

Metrogyl should not be used if high sensitivity to its components. It is also not recommended to take the drug for children under 2 years of age, pregnant women (first trimester), and lactating women.

It is undesirable to prescribe the drug for organic lesions of the central nervous system, epilepsy, and a tendency to seizures.

Blood diseases are considered a contraindication.

The combination of amoxicillin and Metrogyl is not permitted until the age of 18.

In case of impaired renal and liver function, during the second and third trimesters of pregnancy this medicine prescribed with caution.

Overdose

Overdose is characterized by headache, dizziness, ataxia, vomiting, nausea. In severe cases there may be epileptic seizures and peripheral neuropathy.

Elimination of overdose occurs symptomatically, by gastric lavage and the use of enterosorbents.

Metrogyl release form

Metrogyl is sold in the form of tablets, a solution for intravenous administration, a colorless homogeneous gel for external use, a colorless, homogeneous gel for vaginal use, a soft white gel for dental purposes.

Metrogyl gel

Metrogyl is also available in gel form. There are several varieties designed for different purposes: dental gel, gel for external use, gel for vaginal use.

The active ingredient of the gel is Metronidazole. The following excipients are used: crabomer 940, methyl and propyl hydrocarbonate, sodium ededate, purified water.

Avoid contact sun rays to the treated area. During therapy it is necessary to abstain from alcohol.

Treatment with gel is prohibited in childhood less than 6 years. The combination with amoxicillin is approved for use only from 18 years of age.

Metrogyl tablets

Metrogyl is available in the form of biconvex round film-coated tablets. There are 2 types of tablets: pink (200 mg of active substance) and orange (400 mg of active substance).

Tablets should be used for: septicemia, brain abscess and meningitis, respiratory tract infections, tetanus, after surgical intervention in the urinary tract and organs abdominal cavity, anaerobic infections, osteomyelitis, protozoal infections (amebic dysentery, trichomonas urethiritis and vaginitis, giardiasis, amebiasis, balantidiasis, trichomoniasis), gas gangrene.

Metrogyl indications and use

Metrogyl is used in the treatment of infections caused by microorganisms sensitive to metronidazole:

• protozoal infections ( skin infections, balantidiasis, giardiasis, trichomonas urovaginitis, trichomoniasis, amoebic dysentery, amoebiasis of different localizations);
• infections caused by Bacteroides microorganisms: lung abscess, joint and bone diseases, endocarditis, pneumonia, meningitis, sepsis;
• infections caused by other anaerobic microorganisms: liver abscess, peritonitis, endometritis, infectious diseases ovaries, fallopian tubes and vagina and other inflammatory and infectious diseases, the pathogens of which are sensitive to metronidazole;
• ulcers of the duodenum and stomach, the causative agents of which are Helicobacter bacteria pylori;
• pseudomembranous colitis caused by antibiotics.

The drug is also used for prophylactic purposes against the occurrence of anaerobic infections caused by surgery.

Application of Metrogyl gel

The gel must be applied exclusively to cleansed skin; the procedure is carried out in the morning and evening time. The duration of therapy is determined by a doctor or cosmetologist. The product should not be used for more than 4 months. The effect will only appear with regular daily use. Typically, significant improvements are noticeable after 3 weeks.

The gel has a characteristic light texture. After use, it lays down in an even layer, forming a kind of film. After application, dryness and discomfort do not appear (except in cases of allergic reactions). It is good to use Metrogyl for oily skin.

The drug gives good results when used together with specialized cosmetics, with talkers, with some drugs that are not analogues.

Use of Metrogyl tablets

Taking the drug is associated with food. It should be taken after or during meals with a sufficient amount of liquid (milk if it is not possible to eat). The exact dosage is determined by the doctor. Severe cases almost always require an increase in dose.

The standard dose for trichomonas infections is 200 mg 3 times a day (women) and 200-400 mg 3 times a day (men). Treatment lasts 7 days. According to indications, it is possible to repeat the course after 3–4 weeks. Both sexual partners must undergo the treatment course.

Children under 10 years of age are allowed to take 200–400 mg per day. A child over 10 years old should take 400–500 mg per day. It is best to divide the daily dose into 2 doses.

For the treatment of amoebic infections adult dose is 400 mg 3 times a day. The dosage for a child is calculated according to the following scheme: 30 – 40 mg/kg body weight – daily dose, it should be divided into 3 doses. Duration of therapy is 7 – 10 days.

To eliminate infections caused by anaerobic microorganisms sensitive to metronidazole, the adult dose is 200–400 mg with a frequency of 2–3 times a day. The pediatric dose is determined at the rate of 7 mg/kg 3 times a day; an interval of 8 hours must be maintained between doses. Treatment should last about 7 – 10 days.

For prevention purposes, 1000 mg is prescribed once, followed by 200 mg 3 times a day.

Impaired renal function requires a 2-fold dose reduction.

Metrogyl for acne

Metrogyl effectively relieves acne. To do this, you need to purchase the drug in the form of a gel intended for external use.

External remedy eliminates acne (acne vulgaris and rosacea), seborrhea, eczema, trophic ulcers, skin lesions infectious etymology caused by varicose veins or diabetes mellitus.

It is allowed to apply the gel to difficult-to-heal wounds, fissures in the anus, hemorrhoids, and bedsores.

Metrogyl treats demodicosis. In a relationship spider veins at acne the drug is ineffective.

Sometimes the gel causes swelling and redness, slight flaking and dryness, and burning.

Metrogyl for gums

Metrogyl for gums is available in the form of a white soft gel. It is used to get rid of oral diseases and for prevention.

Indications for the use of the gel are infectious diseases of the oral cavity and gums: gingivitis, periodontal disease, periodontitis, a combination of diseases with cheilitis, periodontitis, alveolitis, stomatitis, gingivitis.

The standard course of treatment lasts 7–10 days. In this case, 2 times a day it is necessary to apply the gel to the affected area.

Depending on the specific situation, the duration of treatment may vary.

Metrogyl vaginal gel

Vaginal gel is used to eliminate urogenital trichomoniasis and bacterial vaginosis of various etiologies.

It is required to apply the gel intervaginally once a day for 2 g. You must abstain from sexual activity during treatment.

How side effect Cystitis and frequent urination may appear.

Metrogyl price

The price of the drug Metrogyl ranges from 7 to 34 hryvnia.

Metrogil reviews

Karina

I applied Metrogyl gel to my face for about a month. All acne disappeared during this time. And the first results were noticeable after 2 weeks. An excellent result considering the amount of acne before treatment. In addition to the gel, I used the services of a professional cosmetologist and did regular facial cleansing.

Oksana

My doctor prescribed me complex therapy. The basis of my treatment was a mixture consisting of Metrogyl and doxycycline. To do this, I mixed 1 capsule of doxycycline with a small amount of Metrogyl. The resulting mass was applied to the inflamed area. The product magically accelerated the healing process, the skin healed right before our eyes.

The drug Metrogyl 100 has antibacterial, trichomonacid and antiprotozoal activity. With its help, you can recover from a variety of infections and minimize the consequences of lesions. The drug may be commercially available in the form of a vaginal gel, oral suspension, tablets and composition for local use.

Release form, composition and packaging

In pharmacies the drug is available in the following forms:

1. Infusion solution for intravenous administration (intravenously). Bes color or yellowish. Sold in ampoules of 20 ml (5 pieces per package) or in plastic jars of 100 ml. 1 ml of the drug consists of 5 mg of metronidazole ( active component), Besides, citric acid, sodium hydrogen phosphate anhydrous, injection water, citric acid monohydrate (additional substances).
2. Round pink (200 mg) or orange (400 mg) tablets. Sealed in blisters of 10 pieces. There are 2 or 10 records in a pack. Each tablet contains 400 or 200 mg of the active ingredient. Additional components: color additive II Opadry, Castor oil, hydrogenated, colloidal silicon dioxide, filtered water, corn starch, magnesium stearate.
3. Vaginal gel. Has a homogeneous consistency. Placed in tubes of 30 g. The package includes an applicator. 100 mg of the drug contains 1 mg of metronidazole. Other ingredients: sodium hydroxide, propyl hydroxybenzoate/propylene glycol, pure water, 940-carbomer, edetate disodium.
4. Cream. Yellowish or colorless. Packaged in aluminum tubes of 30 g. 100 mg of ointment contains 1 mg of the active ingredient. Other substances: 940 carbomer, sodium hydroxide, methyl parahydroxybenzoate, disodium edetate, distilled water, propyl parahydroxybenzoate,
5. Oral solution. The bottle contains 100 or 60 ml of product. 1 ml of medication contains 40 mg of the active element.

pharmachologic effect

MP has an antimicrobial and antiprotozoal effect. Its active substance inhibits the production of nucleic acids in cellular structures pathogenic microorganisms that die as a result of this process.

The drug is active against Veillonella spp., Prevotella buccae., Bacteroides fragils and a number of other bacteria (except obligate anaerobes). In addition, the drug increases the sensitivity of malignant and benign formations to the effects of radiation, improves reparative properties and disulfiram-like manifestations.

In patients with normal liver function, T1/2 is 8 hours. In case of kidney problems, the active substance may accumulate in the body, so such patients require dose adjustment.

The drug is excreted by the intestines and kidneys.

Indications

Infusion solution:

• infectious pathologies provoked by Bacteroides spp.: bacterial form of endocarditis, pneumonia, brain abscess, empyema, pulmonary abscess, infections of the central nervous system, bones and joints;
• infections of the protozoal type: giardiasis, vaginitis (trichomoniasis), amoebiasis, balantidiasis, leishmaniasis, urethritis, amoebic form of dysentery;
• pseudomembranous form of colitis, provoked by the use of antibiotics;
• alcohol addiction;
• stomach ulcer;
• gastritis;
• postoperative complications.

Pills:

• infectious lesions respiratory system: pulmonary abscess, pneumonia;
• septicemia, osteomyelitis;
• meningitis;
• brain abscess;
• gas gangrene;
• postpartum sepsis.

Vaginal gel:

• vaginosis;
• urogenital trichomoniasis.

• haemorrhoids;
• bedsores;
• long-healing wounds;
• acne vulgar type;
• oily seborrhea;
• dermatitis;
• pink acne.

Oral suspension:

• giardiasis;
• liver abscess (amebic);
• bacterial pathologies of an anaerobic nature;
• amoebiasis.

Metrogil 100 dosage regimen

• patients over 12 years of age: initial dosage – from 500 to 1000 mg (drops); the infusion should last at least half an hour; if tolerance is good, then jet infusions are used; ultimate daily dose– 4000 mg;
• under 12 years of age: daily dose – 7.5 mg per 1 kg of weight.

To prepare for surgery, the solution is administered at a dose of 500-1000 mg several hours before surgery.

Suspension and tablets should be taken orally with water, juice, tea or fresh milk. Patients over 15 years of age are prescribed 200-400 mg twice or thrice a day.

Doses are selected depending on clinical indications:

• liver abscess: adult dosage - from 1200 to 2400; treatment must be combined with antibiotics; dose for children – from 30 to 35 mg/day per 1 kg of body weight in 3 divided doses; the duration of therapy is 5-10 days;
• trichomoniasis: one-time dosage – 200 mg; Frequency of administration – three times a day; duration of therapy – a week;
• amebiasis: daily norm for adult patients – 400 mg of active substance three times a day; for children – no more than 40 mg/day per 1 kg of weight in 3 divided doses; treatment lasts up to 1-1.5 weeks.

The external ointment is used twice a day. The amount of the drug should be small. Places to be treated must be cleared of contamination in advance. Duration of use – up to 3-4 months. Positive result observed one month after the start of treatment.

Side effects of Metrogil 100

Injection solution and tablets:

• digestive system: dry mouth, hepatitis, stomatitis, loss/decreased appetite, iron taste, pancreatitis;
• hematopoiesis: leukopenia, thrombocytopenia;
• genitourinary system: burning in the urinary canal, candidiasis, polyuria, urinary incontinence;
• CNS: headache, impaired consciousness, epileptic seizures, depressive states;
• allergies: rhinitis, Quincke's edema, fever, skin hyperemia;
• local manifestations (with intravenous administration): swelling and pain in the place where the drug was administered.

Topical cream and vaginal ointment:

• local manifestations: increased urination, burning sensation in the vaginal area;
• systemic reactions: dry mouth, migraines, taste disturbances, changes in the color and consistency of urine, loss of appetite, vomiting/nausea, peeling of the skin, lacrimation.

Contraindications for use

Infusion solution and tablets:

• liver failure;
• diseases of the circulatory system;
• organic pathologies of the central nervous system;
• pregnancy in the 1st trimester;
• lactation;
• allergy to a medication.

Vaginal gel and external cream are not used for severe liver failure, leukopenia, blood diseases and individual intolerance to drug substances.

Special instructions Metrogil 100

Use during pregnancy and breastfeeding

Any forms of MS are not used in the 1st trimester of gestation; in 2 and 3 – admission is for exceptional indications.

Not used for hepatitis B.

Use in children

Until the age of 12, the drug is used carefully and under the supervision of a physician.

Use for liver dysfunction

For organ damage, the maximum daily dosage is 1000 mg. Frequency of use: twice a day.

Frequency of use medicine Metrogyl - twice a day.

Use for renal impairment

When CC is less than 30 ml/minute, the maximum dosage (daily) should be no more than 1 g.

Alcohol compatibility

In combination with alcohol there is a risk of abdominal spasticity. pain syndrome, headache, flushing. Therefore, it is better to refrain from drinking alcohol during therapy.

Storage conditions and periods

The medicine should be stored at moderate temperatures (+10°...+25°C) in a dry/shaded area.

Each of the drug release forms has its own expiration date:

• gel for treating the vaginal area – up to 24 months;
• injection solution and cream – up to 36 months;
• tablets – no more than 5 years;
• oral solution – up to 3 years.

Conditions for dispensing from pharmacies

To purchase other formats of the drug, a prescription is required.

Interaction with other drugs

• anticoagulants: increasing their activity;
• ethanol: the occurrence of negative reactions:
• stimulators of microsomal liver enzymes: stimulation of elimination active substance, which leads to a decrease in its plasma concentration;
• Cimetidine: slowing down the breakdown of metronidazole;
• lithium drug: increased level of lithium in the blood serum, development of symptoms of intoxication;
• sulfonamides: increasing the antimicrobial activity of the drug.

Price

Infusion solution: 20-31 rub. per bottle 100 ml.

Tablets: 110-170 rub. per pack of 20 pcs.

Gel: 190-214 rub. per tube 30 g.

Cream: 150-210 rub. for a 30 g tube.

Suspension: 230-270 rub. for a 100 ml bottle.

Analogues

• Efloran;
• Cyptrogyl;
• Trichopolum;
• Orvagil;
• Nycomed Metronidazole;
• Metron;
• Metrovagin;
• Batsimex;
• Deflamon.

For serious infections, the doctor may prescribe the drug Metrogyl in droppers. Metrogyl solution has a number of contraindications and is prescribed for very limited indications.

Metrogyl - medicine and its action

Metrogyl solution is used for intravenous administration, belongs to the group of antiprotozoal and antibacterial agents. Available in 100 ml bottles, the cost per package is about 150 rubles. The solution is transparent, colorless or light yellow. Manufacturers: Sintez, Unique and others.

The active substance is metronidazole (5 mg/ml), an antiprotozoal agent, a derivative of 5-nitroimidazole.

The drug contains a number of excipients - citric acid, water, sodium hydrogen phosphate, saline solution.

The mechanism of action of the drug has not been reliably studied; it is assumed that the substance disrupts the DNA structure of microorganisms that are sensitive to it. Metronidazole is most effective in diseases caused by:

The drug can be used in second-line regimens for the treatment of Helicobacter pylori in combination with penicillins. Many anaerobes are not sensitive to the drug. Additionally, it has a regenerating effect, accelerates tissue repair, and increases efficiency radiation therapy against tumors.

Indications and contraindications

Most often, as an indication for use, Metrogyl in droppers is prescribed against genital infections.

In women, this is vaginitis caused by Trichomonas and other microbes, as well as endometritis, damage to the vaginal vault and other organs when surgical interventions ah, endomyometritis, giardiasis of the genital organs.

The administration of the solution is practiced for ulcers, purulent cavities in the area of ​​the ovaries, and fallopian tubes.

Dermatological diseases can also be treated with this drug, as well as infectious diseases soft tissues. Thus, treatment is prescribed for tetanus and other diseases caused by anaerobes, and for cutaneous leishmaniasis. Infections internal organs treated by drip for:

Protozoans intestinal infections are treated with a course of droppers with the drug, we are talking about balantidiasis, amoebic dysentery. Treatment is carried out for damage to the organs of the urinary system, bones, joints, brain, heart. For pneumonia, abscess and empyema of the lungs, which are caused by microbes sensitive to Metrogyl, treatment will also bring positive results.

Contraindications include leukopenia, epilepsy, and other organic diseases nervous system, severe blood pathologies, bone marrow, final stages renal failure. In the first trimester of gestation, during lactation, treatment is prohibited; women in the 2-3 trimesters of gestation are treated carefully and according to strict indications.

How to use Metrogyl correctly?

In childhood, therapy is carried out only in a hospital. In adults, due to the seriousness of the indications for the use of the solution, therapy is also performed mainly in conditions medical institution. Dosages and recommendations are as follows:

Usually, droppers are prescribed for only 2-3 days, then they switch to injecting the medicine into a vein. The general course of therapy is a week, the course can be extended individually

Instead of jet administration, metronidazole tablets may be prescribed.

In case of renal or liver failure, the dosage of the drug is selected by the doctor. They will depend on the severity of the disease and indicators biochemical analysis blood.

Analogues and important information about Metrogil

Metrogyl should not be mixed with other medications in the same dropper. It is strictly forbidden to use drunkenness- this leads to the appearance of neurological symptoms.

A number of drugs serve as analogues of Metrogyl (different dosage forms):

The drug often causes diarrhea, dyspepsia, loss of appetite, abdominal cramps, and stomach pain. With a long course there is a risk of developing pancreatitis, stomatitis, glossitis, and depression. Occur frequently allergic reactions, candidiasis, cystitis. When Metrogyl is administered, urine turns brown.

Photo of the drug

Latin name: Metrogyl

ATX code: D06BX01

Active substance: Metronidazole

Manufacturer: Unique Pharmaceutical Laboratories (India)

Description is valid on: 17.01.18

Metrogyl is an antiprotozoal, antibacterial, trichomonacid drug.

Active substance

Metronidazole.

Release form and composition

Sold in the form of tablets, solution for intravenous administration, gel for external use and vaginal gel.

• Tablets are produced in blisters (10 tablets each), placed in carton boxes 2 or 10 pcs. or plastic containers (1000 or 5000 tablets).
• The solution is available in glass ampoules (20 ml each), placed in thermal containers (5 amps each) and cardboard packs of 1 or 5 pcs. Also the drug in this dosage form can be sold in polyethylene bottles (100 ml each), placed in cellophane wrappers (1 bottle each) and cardboard boxes of 1 pc.
• Gel for external use is produced in aluminum tubes (30 g of the drug each), placed in cardboard boxes of 1 pc.
• Vaginal gel is produced in aluminum tubes (30 g of the drug each), placed in cardboard packs of 1 pc. The kit includes an applicator for applying the gel.

The vaginal formulation contains metronidazole (10 mg) and excipients: propyl hydroxybenzoate, carbomer 940, propylene glycol, sodium hydroxide, disodium edetate, purified water.

Indications for use

Pills

Indications:

• anaerobic infections caused by Bac.fragilis and other bacteroids, clostridia, fusobacteria, anaerobic cocci, eubacteria;
• protozoal infections - extraintestinal amebiasis, including trichomoniasis, giardiasis, giardiasis, intestinal amebiasis, amoebic liver abscess, balantidiasis, trichomonas urethritis and vaginitis, cutaneous leishmaniasis;
• conditions after surgical interventions on urinary tract and abdominal organs - pelvic abscesses, intraperitoneal infections, peritonitis, appendicitis, liver abscess, cholecystitis, postpartum sepsis, postoperative wound infections(including prevention of anaerobic postoperative infections);
• infections respiratory tract(lung abscess, necrotizing pneumonia);
• osteomyelitis;
• tetanus;
• septicemia;
• gas gangrene;
• brain abscess, meningitis.

Solution for intravenous administration

Indications:

• infections caused by Bacteroides spp. – abdominal cavity, pelvic organs (endomyometritis, endometritis, abscess of the ovaries and fallopian tubes, infections of the vaginal vault after surgery), infections of soft tissues and skin;
• pseudomembranous colitis (caused by long-term use of antibiotics);
• chronic alcohol dependence;
• ulcer or gastritis of the duodenum caused by Helicobacter pylori.

Gel for external use

Indications:

• seborrheic dermatitis, oily seborrhea, acne vulgaris;
• rosacea (including post-steroid acne);
• bedsores, long-healing wounds;
• trophic leg ulcers (due to diabetes mellitus, varicose veins veins);
• cracks anus, haemorrhoids.

Vaginal gel

Indications: urogenital trichomoniasis, bacterial vaginosis of different origins, confirmed by microbiological and clinical studies.

Contraindications

• blood diseases (including the patient’s history);
• lesions of the central nervous system organic origin(including epilepsy);
• the period of bearing a child (in particular, the first trimester);
• liver failure - when prescribing the drug in high doses;
• hypersensitivity to metronidazole or other components, as well as to other nitroimidazole derivatives.

Additionally for the solution: breastfeeding period.

Additionally for vaginal gel: impaired coordination of movements, leukopenia (including in the patient's medical history).

Instructions for use Metrogyl (method and dosage)

Pills

Take orally, whole, during or after meals. It is advisable to drink it with milk. Children over 15 years of age and adult patients are prescribed 200-400 mg 2-3 times a day. The duration of therapy depends on the nature of the infection.

• For amebiasis, adults should take 400 mg 3 times a day. Children are prescribed 30-40 mg/kg body weight per day (divided into 3 doses). The duration of treatment is 7-10 days.
• For trichomoniasis, 200 mg is prescribed 3 times for 7 days. Women are required to additionally use metronidazole in the form of vaginal ointments or suppositories. If necessary, you can increase the dose to 750-1000 mg per day or repeat the course of therapy. Between courses you need to take a break of 3-4 weeks. An alternative treatment regimen is a single dose of 2 g of the drug by the patient and his sexual partner.
• With anaerobic bacterial infections adult patients are prescribed 200-400 mg of the drug 2-3 times a day, and children - 7 mg/kg body weight every 8 hours. The duration of treatment is 7-10 days. For the purpose of prevention anaerobic infection before surgery on the large intestine and pelvic organs Prescribe a single dose of Metrogyl orally at a dose of 1000 mg, then 200 mg 3 times a day.
• For amoebic liver abscess, adults should take 400 or 800 mg 3 times a day (in combination with tetracycline antibiotics). Children are prescribed 30-35 mg/kg body weight per day (divided into 3 doses). The duration of the course of therapy is 5-10 days.
• In combination with amoxicillin (2.25 g), the daily dose of the drug is 1.5 g, the frequency of administration is 3 times a day. People with severe functional disorders kidneys and liver, the daily dose of metronidazole is 1 g, amoxicillin - 1.5 g. Frequency of administration - 2 times a day.

Solution for intravenous administration

For children over 12 years of age and adult patients, the initial dose is 0.5-1 g intravenously. In this case, the duration of infusions is 30-40 minutes. Next, the drug is administered in a dose of 500 mg every 8 hours at a rate of 5 ml/min. After the first 2-3 infusions, it is necessary to switch to jet administration (if the medication is well tolerated). The duration of the course of therapy is 7 days. The maximum daily dose is 4 g. According to indications, the patient is transferred to maintenance administration of Metrogyl orally at a dose of 400 mg 3 times a day.

For children under 12 years of age, the drug is prescribed in a single dose of 7.5 mg/kg body weight (according to the same regimen).

For purulent-septic pathologies, 1 course of therapy is usually carried out.

For preventive purposes, children over 12 years of age and adults are administered the drug intravenously, 0.5-1 g, on the eve of surgery. On the day of surgery and the next day - 1.5 g per day (500 mg every 8 hours). After 1-2 days, they switch to maintenance treatment orally.

For patients with chronic renal and/or liver failure, the maximum daily dose is no more than 1 g. The frequency of administration is 2 times a day.

Gel for external use

Apply a thin layer to previously cleansed affected skin areas. Frequency of use: 2 times a day, morning and evening, for 3-9 weeks. The total duration of therapy is 3-4 months. Maximum therapeutic effect achieved after 3 weeks of treatment.

Vaginal gel

Intended for intravaginal administration. The recommended dose is 5 g (1 full applicator) 2 times a day, morning and evening. The duration of the course of treatment is 5 days.

Side effects

The use of Metrogyl in tablet form can cause the following: side effects:

• Central nervous system: impaired consciousness, dizziness, depression, headache, increased excitability, sleep problems, peripheral neuropathy, weakness, ataxia, impaired coordination of movements, ataxia, epileptic seizures, hallucinations.
• Digestive system: diarrhea, constipation, intestinal colic, pseudomembranous colitis, dry mouth, increased levels of liver enzymes, attacks of nausea, vomiting, glossitis, pancreatitis, cholestatic jaundice, loss of appetite, stomatitis, hepatitis, metallic taste in the mouth.
• Genitourinary system: polyuria, dysuria, urinary incontinence, red-brown urine, fungal flora of the vagina (candidiasis), burning in the urethra.
• Hematopoietic system: thrombocytopenia, leukopenia, neutropenia.
• Allergic manifestations: fever, arthralgia, nasal congestion, urticaria, skin rashes, itching, skin hyperemia, anaphylactic shock.
• Other: flattening of the T wave on the electrocardiogram.

Additionally for the solution:

• excessive irritability;
• insomnia;
• convulsions;
• local reactions in the form of thrombophlebitis (swelling, hyperemia or pain at the injection site).

Additionally for gel for external use: in rare cases, lacrimation (if the drug is applied close to the eyes), mild dryness, peeling and burning of the skin may occur.

Additionally for vaginal gel: cramping pain in the abdominal cavity, vulvitis, frequent urination. The sexual partner may experience irritation or a burning sensation in the penis.

Overdose

When taking large doses of Metrogyl tablets, nausea, vomiting, and ataxia may develop. In severe poisoning, peripheral neuropathy develops, and epileptic seizures are sometimes possible.

Treatment is symptomatic.

Analogues

Analogs by ATC code: Metrovagin, Metronidazole, Trichopol, Trichosept, Flagyl.

Do not decide to change the drug on your own; consult your doctor.

pharmachologic effect

Metronidazole is an antiprotozoal and antibacterial agent wide range actions. The mechanism of action is the reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of microbial cells, inhibiting the synthesis of their nucleic acids, promoting the death of bacteria.

special instructions

• Do not drink alcohol while taking the drug (there is a risk of developing a disulfiram-like reaction).
• Concomitant use with amoxicillin is not advisable in patients under 18 years of age.
• With leukopenia, the possibility of continuing therapy depends on the risk of an infectious process.
• Long-term use should preferably be carried out under monitoring of peripheral blood parameters.
• Taking the drug may cause a false positive Nelson test.
• The appearance of dizziness, ataxia and deterioration of the patient's neurological status requires discontinuation of treatment.
• When treating trichomonas urethritis in men and trichomonas vaginitis in women, you should abstain from sexual activity. Simultaneous therapy of sexual partners is mandatory. It is not advisable to stop taking the drug during menstruation. After treatment of trichomoniasis, control tests must be carried out during 3 consecutive cycles before and after menstruation.
• After treatment of giardiasis, if signs of the disease persist, after 3-4 weeks, 3 stool tests are required with a break of several days.
• When using the gel, it is recommended to avoid contact of the drug with the eyes. If this happens, you must immediately rinse the mucous membrane with plenty of water.

If the doctor recommended Metrogyl droppers to the patient, then questions arise. It is important to understand how it affects the human body. Metrogyl is prescribed for inflammatory processes, giardiasis or gynecological pathologies. Let's look at how the Metrogyl dropper is used and how to place it correctly, indications and side effects.

Description of the drug

The main effect of Metrogil is antibacterial. Once in the patient’s body, metrogil kills pathogenic bacteria.

Metrogyl is available in three pharmacological forms:

• Solution for intravenous injection. Available in a plastic container with a volume of 100 ml or in the form of ampoules of 20 ml. One package contains 10 ampoules or 1 bottle.
• Pills in blister packs. Dosage 200 and 400 mg. Sold in packs of 10, 50, 100 pcs.
• Suspension for oral administration. Glass bottle in a box of 60 and 100 ml.

The effectiveness and choice of form for administration depends on the type of disease. A drip for intravenous administration, tablets and suspension are prescribed only by a doctor. You can independently use the injection solution when rinsing the nasopharynx as a disinfectant.

The solution for droppers has a light yellow. The solution must be clear, without sediment and sterile.

The solution for injection is dispensed from pharmacies only according to prescription.

Purpose of the drug

Metrogyl solution for injection has the following indications:

• Treatment and as a prophylactic against airborne infections in the preoperative period. Frequent indications before operations on the urinary system and gastrointestinal tract.
• Indications for mixed infections of various etiologies.
• Purulent-serous infections (intestinal amebiasis, sepsis, abscess of the brain or pelvic organs, peritonitis, suppuration of the skin or soft tissues, bone and joint lesions).
• Indications for intravenous acute form diseases: giardiasis, trichomonas vaginitis, urethritis, amoebiasis. On initial stage suspension is used.

After the dropper, the concentration of metrogil in the blood is 35.2 mcg/ml. It falls gradually and is eliminated unchanged by 80%. Complete blood purification occurs on the third day after the last dropper.

Dosage for infusion

The drug is prescribed intravenously only for acute forms of the disease. At the initial stages, oral forms are prescribed - tablets, suspension. Their regimen for use will depend on the form and type of disease.

Adult dosage

Metrogil droppers adult scheme Can also be used by children over 12 years of age. Instructions for use:

• The first dose is 0.5–1 g with a dropper duration of 30–40 minutes.
• Further, the course is prescribed once every 8 hours with a dosage of 500 mg. The solution injection rate is 5 ml/min.

If a child or adult has good infusion tolerance, then after 3–4 droppers they switch to jet administration. The duration of the IV course is 7–8 days. If the infection progresses further, the course is extended. In 24 hours, the maximum amount of metrogyl for an adult is 4 g.

After the drip, Metrogyl is prescribed in the form of tablets or suspension, 200 mg/2 times a day, as maintenance therapy.

Pediatric dosage

For children, the solution for administration is prescribed in the most extreme cases. The application regimen is similar to that for adults. The dosage is selected for each child individually, but should not exceed 7–8 mg/kg of weight per administration.

In many ways, the regimen for use and purpose depends on the type of disease. If Metrogyl droppers were prescribed for purulent infections, then one course of administration is sufficient for recovery. In the preoperative period, adults and children over 12 years of age are prescribed 1 infusion of 0.5–1 g 24 hours before surgery. On the day of surgery, 1.5 g of metrogil is instilled according to the regimen of 500 mg/administration every 8 hours.

After surgery, on the second day, maintenance treatment with tablets or suspension is prescribed. If the patient has renal failure, then the dosage of the dropper is reduced to 1 mg/2 injections per day.

In the treatment of cancer, metrogil is used as a radiosensitizing agent. The dropper is placed 2–3 hours before the start of the irradiation procedure at a dosage of 160 mg per 1 kg of patient weight. Next, the procedure is repeated for 2 weeks, before each irradiation procedure. Maximum dosage per administration should not exceed 10 g, per course should not exceed 60 g of the drug. At the remaining stage of radiation therapy, the drug is not used.

For uterine oncology, Metrogyl is not given by dropper. Before irradiation, it is enough to make an application of 3 g of metrogil and dimethyl sulfoxide 10%.

What side effects should you expect and when should you not use the drug?

When treating Metrogyl with droppers, you should expect side effects. Conventionally, side effects can be divided into common and rare.

Some of the most common ones include:

• The nasopharyngeal mucosa dries out.
• Single nausea.
• Loss of appetite.
• Dull pain in the gastrointestinal tract.
• Metallic taste in mouth.

Less commonly observed side effects:

• From the gastrointestinal tract: stool retention, nausea, occasional vomiting.
• From the side of the central nervous system: loss of coordination, dizziness, hyperexcitability, loss of sleep, migraines, general weakening of the body.
• Allergic manifestations from the body: skin rashes, swelling of the nasopharyngeal mucosa, hyperemia of the skin.
• From the outside urinary system: incontinence, urine becomes red or dark brown, cystitis, candidiasis, increased protein in the urine.
• On the vascular side, increased thrombophlebitis.

In rare cases, a Metrogyl drip may cause hallucinations, loss of consciousness, or confusion. In one out of 100 patients, the drug causes pancreatitis, so people with gastrointestinal disorders should be treated with caution.

Contraindications for the medication

The drug is contraindicated for people with the following diseases:

• The patient had a history of intolerance to metronedazole and its derivatives.
• Pathologies and disorders of the central nervous system.
• High dosage is contraindicated in people with liver failure.
• Any blood diseases.
• The first three months of pregnancy and the period of breastfeeding.

Metrogyl should not be taken simultaneously with other medicines. It is not recommended to take dietary supplements and nutritional supplements. It is especially dangerous to use droppers together with drugs that contain ethanol. The patient is strictly prohibited from drinking alcohol throughout the course of treatment and for 2 weeks after its completion.