Benzonal instructions international name. Benzonal - instructions for use

Prohibited during breastfeeding

Has restrictions for children

Has restrictions for older people

Prohibited for liver problems

Prohibited for kidney problems

Convulsive conditions can occur at any age and are more severe in children. To relieve them, as well as to stop epileptic attacks, they are prescribed special means. One of them is Benzonal. According to the instructions for use, the product can be used in pediatrics, but Benzonal is a potent aggressive drug, so its use requires increased supervision by a specialist.

General information

Benzonal is a popular antiepileptic drug. It belongs to the list of potent drugs, therefore it is prescribed only if there are appropriate indications. Domestic medicine is produced pharmaceutical company Aspharma LLC.

Drug group, INN, application

The drug is classified as a special drug group barbiturates and their derivatives. Such drugs have antiepileptic and anticonvulsant effects.

International generic name The use of a medicine depends on the content of the active substance in it, which determines its action in the body. Benzonal's INN is benzobarbital.

Use the medicine in different areas medical practice. It is intended for relief and prevention convulsive conditions And epileptic seizures both in adults and children of different ages.

Release form, cost

In pharmacies, the drug can be purchased in the form of tablets, each of which contains 50 or 100 mg of the active ingredient. Such tablets have a flat cylindrical shape and are white in color. They are packaged in cell blisters of 10 pieces.

Benzonal can be purchased at a pharmacy with a special prescription from a doctor. Its price depends on the content active substance in 1 tablet and their quantities in the package. Also, the cost may vary in different pharmacies.

Today it is very difficult to find the drug in pharmacies in Moscow and other Russian cities. It is practically not available anywhere, since it is included in the list of potent and poisonous medicines. As a rule, to get it, you must have a prescription and pre-order it by phone or on the pharmacy website. We managed to find the medicine in 2 pharmacies in Moscow - Avicenna Pharma and Terravita. The cost of a package of 50 tablets of 100 mg each ranges from 99 to 110 rubles.

Composition and pharmacological properties

The drug contains the active substance benzobarbital. 1 tablet contains 50 or 100 mg. Additionally there are auxiliary components - potato starch, methylcellulose and stearic acid.

The action of benzobarbital is directed at special receptors of the central nervous system, the antagonist of which is gamma-aminobutyric acid (GABA). This substance reduces the permeability of the membranes of sodium nerve fibers, which helps reduce the spread of impulses from foci of epileptic activity.

This ensures an antiepileptic and anticonvulsant effect. At the same time, the drug helps to increase the monooxygenase enzyme system of the liver, accelerates the transformation of bilirubin and other liver enzymes. Does not have a hypnotic effect.

Active substance, metabolized in the body, releases phenobarbital, which provides an antiepileptic effect. It practically does not bind to blood proteins; its highest concentration is mainly observed in the tissues and extracellular fluid of the brain, kidneys and liver. Benzobarbital is able to penetrate the placental barrier and into breast milk. It is excreted in the form of metabolites and unchanged in the urine. Half-life occurs within 3-4 days.

Indications and restrictions

The drug is prescribed by the attending physician if the patient has appropriate indications. It is taken for:

• convulsive forms of epilepsy of various origins. With the help of this remedy they treat generalized and focal epilepsy, partial seizures and epileptic syndrome;
• seizures that are not accompanied by convulsions (minor);
• polymorphic seizures.

In some cases, the medicine is used for functional or benign hyperbilirubinemia (including posthepatitis), which is accompanied by cholestasis and hemolytic jaundice.

Benzonal has some contraindications that should be considered before prescribing it. This drug should not be taken if:

The drug can be used in pediatrics and is prescribed for the treatment of seizures in children over 3 years of age. Before this age, the medicine should not be given, as it promotes toxic damage child's liver.

Pregnant women are also not recommended to take this medicine. Benzobarbital can cross the placenta and cause severe fetal malformations. Therefore, women of reproductive age who take Benzonal should take care of reliable contraception.

Instructions for use

The dosage of the drug is selected by the attending physician individually for each patient, depending on his age and the nature of the seizures. The instructions for taking Benzonal include the following recommendations:

The drug is taken for a long time - for a year or more. At the same time, it should be consumed regularly, 1 single dose per day, even in the absence of attacks. If seizures return, the previous dosage should be resumed.

It is important to remember that the medicine is contraindicated to be taken in combination with certain medications. It enhances the effect of such drugs:

• narcotic painkillers;
• tricyclic antidepressants;
• means for general anesthesia;
• tranquilizers and neuroleptics;
• sleeping pills.

Side effects, overdose symptoms

Benzonal is a potent and poisonous drug. Therefore, when taking it, the following negative phenomena are often observed:

• lethargy, lethargy, drowsiness;
• significant decrease in blood pressure;
• the appearance of headache;
• loss of appetite;
• inhibition of hematopoiesis (anemia, thrombocytopenia, thrombophlebitis);
• bronchospasm;
• allergic manifestations;
• slowing down of mental reactions;
• impaired coordination of movements;
• nystagmus (twitching of the eyelid);
• speech problems.

It is also possible to develop dependence on the medication. After stopping treatment (especially long-term), withdrawal syndrome is often observed.

An overdose can cause very serious problems. In this case, symptoms of intoxication appear:

• dysfunction of the central nervous system, which is manifested by drowsiness, vision problems, ataxia and nystagmus;
• development of a coma;
• respiratory depression;
• a sharp drop in blood pressure;
• headache;
• high or low body temperature;
• constriction of the pupils;
• disturbance of cardiac activity (slowing or accelerating its contractions);
• hemorrhages;
• blue discoloration of the skin.

If a person develops chronic benzobarbital poisoning, he becomes irritable, sleeps poorly, and is unable to critically assess the situation. Treatment for overdose involves removing it from the body. harmful substances. This requires gastric lavage and sorbents. In severe cases, the patient is prescribed diuretics and hemodialysis. Then symptomatic therapy is applied.

The best analogues

In modern medical practice benzobarbital-based products are rarely used. This substance has pronounced side effects and has a toxic effect on the body. Therefore, in most cases, Benzonal analogues are used, which have a similar effect, but are safer. Among them:

Any antiepileptic drug is prescribed only by the attending physician. It can be purchased in pharmacies only with a special prescription.

Instructions for medical use drug

Description of pharmacological action

Strengthens inhibitory GABAergic effects in the central nervous system.

Indications for use

Convulsive forms of epilepsy of various origins(especially with cortical localization of the epileptoid focus), non-convulsive and polymorphic seizures (in combination with other antiepileptic drugs), functional hyperbilirubinemia, incl. posthepatitis, Gilbert's disease, cholestatic form chronic hepatitis, recurrent benign intrahepatic cholestasis, hemolytic jaundice.

Release form

Benzonal

Benzonal

Benzonal
tablets 100 mg; contour packaging 10 cardboard pack 5

Benzonal
tablets 100 mg; polymer jar (jar) 50 cardboard pack 1

Benzonal

Benzonal

Benzonal
tablets 100 mg; contour packaging 10 cardboard pack 5

Benzonal
tablets 50 mg; contour packaging 10 cardboard pack 3

Benzonal
tablets 50 mg; contour packaging 10 cardboard pack 5

Benzonal
tablets 100 mg; jar (jar) 50 cardboard pack 1

Benzonal
tablets 100 mg; jar (jar) 50 cardboard box (box) 50

Benzonal
tablets 100 mg; polymer jar (jar) 50 cardboard box (box) 50

Benzonal
tablets 100 mg; dark glass jar (jar) 50 cardboard box (box) 50

Benzonal
tablets 100 mg; contour packaging 10 cardboard box (box) 600

Benzonal

Benzonal
tablets 100 mg; contour packaging 10 cardboard pack 5

Benzonal
tablets 100 mg; contour packaging 50 cardboard pack 5

Benzonal
tablets 100 mg; dark glass jar (jar) 50 cardboard pack 1

Benzonal
tablets 100 mg; contour packaging 10 cardboard pack 1

Benzonal
tablets 100 mg; contour packaging 10 cardboard pack 2

Benzonal
tablets 100 mg; contour packaging 10 cardboard pack 5

Benzonal
tablets 100 mg; contour packaging 10 cardboard pack 5

Benzonal
tablets 100 mg; contour packaging 25 cardboard pack 2

Pharmacodynamics

Reduces epilepsy attacks. Increases the activity of the monooxygenase enzyme system of the liver, enhances the processes of acetylation and glucuronidation, accelerates the biotransformation of exo- and endogenous compounds, including bilirubin.

Use for renal impairment

Contraindicated.

Contraindications for use

Severe parenchymal liver damage, renal dysfunction, cardiac decompensation.

Side effects

Addiction, drug dependence, withdrawal syndrome, bronchospasm, decreased blood pressure, thrombocytopenia, anemia, thrombophlebitis, drowsiness, lethargy, lethargy, headache, decreased appetite, difficulty speaking, ataxia, nystagmus, slowed mental reactions; allergic reactions.

Directions for use and doses

Inside, after eating. Doses vary depending on age, nature and frequency of seizures. For adults - 0.1 g 3 times a day (highest daily dose - 0.8 g), for children (3 times a day): 3–6 years old - 0.025–0.05 g, 7–10 years old - 0. 05–0.1 g, 11–14 years old - 0.1 g (highest daily value - 0.45 g); treatment begins with a single dose, after 2-3 days the daily dose is gradually increased to the optimal; The duration of taking the maintenance dose is individual (depending on the effectiveness), it is recommended - at least 2 years (even after the seizures have stopped).

For hyperbilirubinemia, take for 2–3 weeks in a dosage regimen similar to that for epilepsy.

Interactions with other drugs

Enhances the effect narcotic analgesics, PM for general anesthesia, antipsychotic drugs (neuroleptics), anxiolytics, tricyclic antidepressants, ethanol, hypnotics; reduces - paracetamol, anticoagulants, tetracyclines, griseofulvin, GCS and MCS, cardiac glycosides, quinidine, vitamin D, xanthines.

Precautions for use

When switching to other anticonvulsants it is necessary to maintain a ratio equivalent in potency (between benzonal and other drugs).

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C.

Best before date

ATX classification:

** The Drug Directory is intended for informational purposes only. To get more complete information Please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Benzonal, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of a positive effect. medicine.

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Compound

1 tablet contains:
Active substance:
Benzobarbital (benzonal), calculated as 100% substance - 100 mg.
Excipients: potato starch, povidone (kollidon 90 F), sodium carboxymethyl starch, calcium stearate.

Description

Pills white, round, flat-cylindrical in shape with a chamfer and a notch.

Indications for use

All forms of epilepsy (except absence seizures).

Contraindications

Hypersensitivity, liver failure, chronic renal failure, chronic heart failure stage II-III, porphyria, anemia, bronchial asthma, respiratory failure, diabetes mellitus, thyrotoxicosis, adrenal insufficiency, hyperkinesis, depressive states (with suicidal tendencies) torture), pregnancy (I and III trimester), period breastfeeding, children's age up to 7 years.

Pregnancy and lactation

The use of the drug is contraindicated in the first and third trimesters of pregnancy. The use of the drug in the second trimester of pregnancy is possible if the expected benefit to the mother outweighs the potential risk to the fetus.
During the treatment period, it is necessary to decide whether to stop breastfeeding.

Directions for use and doses

Orally, after meals, 3 times a day. The dosage regimen is individual and prescribed by a doctor. Treatment begins with a single dose. After 2-3 days, the dose is gradually increased until a clinical effect is achieved (reduction in frequency or complete cessation of seizures). The course of treatment is continuous and long-term, at least 2 years. Single dose - 100 - 150 - 200 mg; highest single dose- 300 mg, the highest daily dose is 800 mg.
For children 7-10 years old, a single dose is 50-100 mg, a daily dose is 150-300 mg; 11-14 years single dose - 100 mg, daily dose - 300-400 mg; the highest single dose for older children is 150 mg; the highest daily dose is 450 mg.

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Side effect

From the nervous system: dizziness, weakness, fainting, impaired coordination of movements, agitation, lethargy, irritability, headache, hand tremors, drowsiness, paradoxical reaction (especially in children, elderly and weakened patients - unusual arousal), hallucinations, depression, “nightmarish” dreams, sleep disorders.
From the musculoskeletal system: with long-term use - impaired osteogenesis, rickets.
From the outside digestive system: nausea, vomiting, constipation, with prolonged use - impaired liver function.
From the hematopoietic organs: agranulocytosis, megaloblastic anemia, thrombocytopenia.
From the cardiovascular system: decreased blood pressure. Allergic reactions: skin rash, urticaria, swelling of the eyelids, face and lips, difficulty breathing, rarely - exfoliative dermatitis, malignant exudative erythema (Stevens-Johnson syndrome).
Other: visual impairment, long-term use can lead to barbiturate dependence; abrupt cessation of taking Benzonal can lead to the development of “withdrawal syndrome”: minor symptoms (within 8-12 hours after stopping the drug) - anxiety, motor restlessness, muscle twitching, hand tremors, weakness, dizziness, blurred vision, nausea, vomiting, sleep disturbance, nightmares, orthostatic hypotension; main symptoms (within 16 hours and lasts up to 5 days) - convulsions, hallucinations.

Overdose

Intoxication with the drug is manifested by depression of the functions of the central nervous system (drowsiness, blurred vision, ataxia, dysarthria, nystagmus), up to coma. There is depression of the respiratory center, decreases arterial pressure, kidney function is impaired.
Symptoms: headache, lethargy, severe weakness, increase or decrease in body temperature, slowing and difficulty breathing, shortness of breath, agitation, constriction of the pupils, tachy- or bradycardia, cyanosis, hemorrhages in pressure areas, confusion, pulmonary edema, coma. With chronic intoxication - irritability, weakened ability to critically evaluate, sleep disturbance, confusion. Treatment: symptomatic and resuscitation therapy aimed at restoring and maintaining the function of the respiratory and cardiovascular systems, liver, kidneys, and central nervous system. These measures include tracheal intubation in a comatose state, artificial ventilation lungs with central hypoventilation, active antibiotic therapy and intravenous therapy solutions of glucose and electrolytes, application cardiovascular drugs and hormones.

Interaction with other drugs

If you are taking any other medications, be sure to tell your doctor!
Effect of other drugs on Benzonal
. Alcohol - simultaneous intake with alcohol can lead to a potentiation of the inhibitory effect on the central nervous system. The same effects are observed when taken together with other CNS depressants.
Antidepressants - including MAO inhibitors, SSRIs and TCAs may reduce the antiepileptic activity of Benzonal by lowering the seizure threshold.
Antiepileptic drugs - plasma concentrations of Benzonal increase when taken simultaneously with oxcarbazequine, phenytoin and sodium valproate.
Vigabatrin - there is evidence of a decrease in the plasma concentration of Benzonal.
Neuroleptics - simultaneous use of aminazine or thioridazine with Benzonal can lead to a mutual decrease in plasma concentration.
Folic acid - prescription of drugs folic acid for the treatment of folic acid deficiency, which may occur with the use of Benzonal, causes a decrease in plasma levels of Benzonal, which leads to insufficient control of seizures in some patients.
Memantine - the effectiveness of Benzonal may be reduced.
Methylphenidate - may increase plasma concentrations of Benzonal.
Medicines based on St. John's wort - the effectiveness of Benzonal can be reduced when used simultaneously.
Effects of Benzonal in relation to other drugs
Benzonal increases the rate of metabolism of the following drugs, which leads to a decrease in plasma concentrations:
antiarrhythmic drugs - disopyramide and quinidine - a decrease in concentrations that support the antiarrhythmic effect is possible. When prescribing or discontinuing Benzonal, monitoring of plasma concentrations of antiarrhythmic drugs is necessary. Their dosage regimen may need to be changed.
antibacterial drugs- chloramphenicol, doxycycline, metronidazole and rifampicin. It is necessary to avoid the simultaneous use of telithromycin during and for 2 weeks after taking Benzonal.
anticoagulants.
antidepressants - paroxetine, mianserin and tricyclic antidepressants.
antiepileptic drugs - carbamazepine, lamotrigine, tiagabine, zonisamide, primidone and possibly ethosuxamide.
antifungal drugs- the antifungal effect of griseofulvin may be reduced or absent when taken simultaneously with Benzonal. Benzonal may reduce plasma concentrations of itraconazole and posaconazole. Not recommended joint reception with voriconazole.
neuroleptics - Benzonal may reduce the plasma concentration of aripiprazole.
antiviral drugs- Benzonal may reduce plasma concentrations of abacavir, amprenavir, darunavir, lopinavir, indinavir, nelfinavir, saquinavir.
anxiolytics and sleeping pills - clonazepam.
aprepitant - Benzonal may decrease plasma concentrations of aprepitant.
beta blockers - metoprolol, timolol and possibly propranolol.
calcium channel blockers - Benzonal leads to a decrease in the level of felodipine, isradipine, diltiazem, verapamil, nimodipine and nifedipine, which may require increasing their doses.
cardiac glycosides - when used simultaneously with Benzonal, the concentration of digitoxin in the blood can be halved.
piclosporin and tacrolimus. corticosteroids.
cytostatics - Benzonal may reduce plasma concentrations of etoposide and irinotecan.
diuretics - simultaneous use of Benzonal with eplerenone is not recommended.
haloperidol - plasma concentrations are reduced by approximately half when used simultaneously with Benzonal.
Hormone antagonists - gestrinone and possibly toremifene.
methadone - when used simultaneously with Benzonal, plasma concentrations may decrease and withdrawal symptoms may appear, which may require an increase in the dose of methadone.
estrogens - decreased contraceptive effect.
progestogens - decreased contraceptive effect.
theophylline - an increase in the dose of theophylline may be required.
hormones thyroid gland- It may be necessary to increase the dose of thyroid hormones in case of hypothyroidism.
Barbiturate vitamins may increase the need for vitamin D.
enhances the effects of sodium hydroxybutyrate. Concomitant use not recommended.

Features of application

Effect of the drug on the ability to drive a car or use machinery
While taking benzobarbital, it is necessary to refrain from potentially dangerous activities that require increased concentration and speed of psychomotor reactions.

Precautionary measures

Reduces the concentration of bilirubin in the blood serum. Caution should be exercised in debilitated patients ( high risk the occurrence of paradoxical arousal, depression and confusion even when prescribed normal doses), in patients with acute and/or chronic pain syndrome (paradoxical arousal is possible or may be masked important symptoms). To avoid the development of withdrawal syndrome, treatment should be stopped gradually. During treatment, the function of the liver, kidneys, general analysis blood.
Use with caution for anemia, chronic obstructive pulmonary disease, bronchospasm (including history), status asthmaticus, dyspnea, diabetes mellitus, drug dependence, liver failure (including a history), hepatic coma, hyperkinesis, thyrotoxicosis, adrenal hypofunction (including borderline conditions), depression, suicide, acute and/or chronic pain syndrome, as well as in weakened patients.
Patients treated with antiepileptic drugs experience mood changes and suicidal thoughts. The mechanism of these changes is unknown, and the available information does not exclude the possibility of an increased risk of suicide when taking Benzonal. Patients taking Benzonal should be closely monitored for signs of depression, suicidal thoughts or behavior. If signs of suicidal thoughts or behavior occur, patients should be advised to seek immediate medical attention. medical care to the doctor.
Life-threatening conditions have been reported with the use of Benzonal: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Patients should be warned of the signs and symptoms of these conditions and closely monitored for skin reactions. The highest risk for SJS or TEN occurs during the first week of treatment. If symptoms or signs of SJS or TEN appear (eg, progressive skin rash, often with blisters or mucosal lesions), treatment with Benzonal should be discontinued. If a patient has a history of developing SJS while using Benzonal, Benzonal should not be prescribed to such a patient.

Benzonal is an anticonvulsant drug that contains the active ingredient benzobarbital in an amount of 0.1 g per 1 tablet. There is also a medicine intended for the treatment of children, in which the concentration of the substance is 0.5 g.

Pharmacological action of Benzonal

The instructions for Benzonal state that the drug produces an antiepileptic effect. Moreover, the drug has almost no hypnotic effect. Active ingredient enhances inhibitory GABAergic effects on the central nervous system. It also reduces the spread of impulses from the epileptic focus, reducing the permeability of nerve fiber membranes to Na+. After oral administration therapeutic effect achieved after 20-60 minutes.

Benzonal is an enzyme “inducer” that increases the activity of the liver monooxygenase enzyme system, which makes it possible to use it for hyperbilirubinemia.

The drug is quickly absorbed through the surface of the gastrointestinal tract. Binding to blood plasma proteins is weak. Elevated drug concentrations occur in the liver, brain, and kidneys. The active substance Benzonal penetrates histohematic barriers and also enters milk.

The drug is quickly metabolized by the body, and phenobarbital is released, which has a corresponding effect - eliminating epileptic seizures. The drug then goes through oxidation by the cytochrome P450 system. Drugs are eliminated through the kidneys in the form of metabolites, as well as unchanged.

Indications for use of Benzonal

The instructions for Benzonal indicate that the medicine is prescribed for:

• convulsive syndrome, minor seizures (non-convulsive), epilepsy of various origins;
• non-convulsive and polymorphic seizures - in combination with carbamazepine, hexamidine, diphenine and other antiepileptic drugs;
• functional hyperbilirubinemia;
• hemolytic disease of newborns - as part of complex therapy.

Directions for use and dosage

It is recommended to take the tablets after meals, orally, with the required amount of liquid. According to the instructions, Benzonal can be combined with other drugs of similar action. The most effective dosage and duration of treatment should be selected by the doctor for each patient.

• 0.1-0.2 g per dose - for the treatment of adult patients. The daily dosage should not exceed 0.8 g. Basically, the medication is taken 3 times a day, 0.1 g;
• 0.025-0.1g – for the treatment of children. Daily dose– 0.1-0.4g, which depends on the age of the patient.

Treatment with the drug begins with a single dose, but after 2-3 days the amount is increased until the desired clinical effect is obtained, that is, until seizures are stopped or their frequency is reduced.

From reviews of Benzonal, we can conclude that treatment with the drug is long-term and lasts at least 1-3 years. The tablets are taken once a day in the amount of a single dose. If seizures return, the patient should begin taking Benzonal again according to the initial dosage.

The maximum permissible dose of the drug at one time is 300 mg.

If the patient was taking other drugs with anticonvulsant effects, then the transition to the drug Benzonal should occur gradually. Initially, one dose is replaced, then after 3-5 days all other doses are replaced.