Home Hygiene Fluoxetine synonyms analogs. We choose fluoxetine analogues depending on the goal

Hygiene

Fluoxetine synonyms analogs. We choose fluoxetine analogues depending on the goal

Fluoxetine, also known by the trade name Prozac, is one of the most popular antidepressants belonging to the group of selective serotonin reuptake inhibitors.

It was created in 1974 and, after passing all the necessary safety checks, went into retail sale in 1987. Over the years on the market it has confirmed its high efficiency and has not lost its relevance to this day. The number of prescriptions written worldwide for fluoxetine-containing antidepressants is in the hundreds of millions.

A detailed academic article about this drug can be read on Wikipedia.

The principle of action of fluoxetine can be presented in a highly simplified form, “on the fingers”, as follows.

Our body contains a neurotransmitter - serotonin. It affects many internal processes, including digestion and vascular tone, but primarily on our mental well-being - self-confidence, calmness, and the ability to enjoy life. If for some reason the level of serotonin is insufficient, a person may begin to experience depression, blues, complexes for far-fetched reasons, and always doubt himself.

Why the body may experience serotonin deficiency is a complex and multifaceted question. We are more interested in what can be done to bring its balance back to normal. And there are two ways to bring the balance back to normal - increase the incoming flow or reduce the outgoing flow.

The incoming flow can be increased by the most different ways- for example, systematic exercise or oriental health practices, meditation. The problem is that often a person lacking serotonin does not have the strength to force himself to do this, and then wait for the results.

Another way to increase influx is by drinking alcoholic beverages. When alcohol enters the body, it causes a sharp release of serotonin, which improves mood, internal stiffness disappears, and life begins to seem more pleasant and colorful for a while. And then the intoxication passes, the level of serotonin drops back, and the need to repeat occurs. The negative impact of alcohol on the ability to think and its general destructive effect on the body is obvious to everyone, but, unfortunately, for many people, alcohol abuse is the only known and tested effective way to somehow maintain their psycho-emotional state.

But serotonin is produced in varying quantities by any organism! This means that it is not necessary to interfere with the processes of its production - you can try to somehow slow down its elimination and come to a normalization of the balance on this side. It is on this principle that the effect of fluoxetine is based - it initiates the reuptake of serotonin, preventing it from being eliminated as quickly as before. Coupled with the fact that serotonin is produced in some volumes in one way or another in the body, this eventually leads to an increase in its amount.

This path is much more gentle, since we do not introduce into the body anything beyond what was already in it, and it is much better controlled in terms of the intensity of the impact - unlike alcohol, which provokes an excessively large one-time release of serotonin, or playing sports , the one-time effect of which is insufficient, and the cumulative effect is overly extended over time.

In more scientific language, the principle of action of fluoxetine and other SSRI drugs is described in the instructions for them, and is more clearly shown in the video below.

Medicines containing fluoxetine

There are currently many fluoxetine-based antidepressants available in the market under different brand names.

Prozac
Prodep
Profluzak
Fluval
Fluoxetine
Fluoxetine-Acree
Fluoxetine-Canon
Fluoxetine Hexal
Flunisan
Fluoxetine hydrochloride
Fluoxetine Lannacher
Apo-Fluoxetine
Fluxen

The best fluoxetine-containing drug

Which of the drugs available on the market is the best? In fact, this is a difficult question, because at the core of all of them lies the same active substance- fluoxetine, and it is unclear how, apart from the trade name, one drug differs from another. Therefore, it is recommended to start with one of the two most common brands in Russia - Fluoxetine-Canon or Fluoxetine Lannacher. Both drugs have many positive reviews. In rare cases, it may turn out that the purchased drug is subjectively “not for you” - this is completely normal, and in such a situation it is worth trying to simply replace fluoxetine with one trademark another.

And in order not to feel the agony of choice, you can immediately give preference to Prozac, the oldest drug based on fluoxetine, which was brought to the market by Eli Lilly, which originally discovered and registered the substance fluoxetine in 1974. The only disadvantage of Prozac is its higher cost compared to analogues.

Fluoxetine analogues

Analogs of fluoxetine include other antidepressants from the SSRI group.

Sertraline (Zoloft)
Paroxetine (Paxil)
Citalopram
Escitalopram (Cipralex)
Alaproclat
Fluvoxamine (Fevarin)
Etoperidone
Zimelidin
Dapoxetine
Indalpin
Vilazodone
Venlafaxine
Desvenlafaxine
Duloxetine
Milnacipra
Levomilnacipran
Atomoxetine
Bupropion

Their action is based on the same principle, but different active ingredients. In case of individual intolerance to fluoxetine or insufficient effect, it is necessary to try other drugs.

In no case should you start taking a new SSRI drug less than 2 weeks after stopping the previous SSRI drug or MAO inhibitor antidepressants. Ignoring this prescription will result in the interactions of several different active substances of the SSRI group superimposing on each other, which can provoke serotonin syndrome - a very unpleasant and potentially fatal phenomenon.

useful links

Recommendations for choosing an SSRI drug for depressive disorder

Prescription for fluoxetine

Fluoxetine is dispensed from pharmacies by prescription, since the decision to prescribe antidepressants and other psychoactive drugs can only be made by a qualified specialist after personal consultation with the patient.

Can I buy fluoxetine without a prescription?

However, it is quite possible to buy fluoxetine even without a prescription. Since this drug does not produce a euphoric effect and is not suitable for use for recreational purposes, and is not a precursor for the manufacture of narcotic drugs, it is not included in the list of drugs for medical use, subject to subject-quantitative accounting.

How to buy fluoxetine without a prescription

To purchase fluoxetine without a prescription, you need to give the impression of a sane adult who controls himself and understands what he is doing.

It should be understood that the decision to dispense a particular drug without a prescription is primarily a matter of morality. Therefore, it is likely that a pharmacy pharmacist will want to refuse to sell to a person who can be mistaken for a teenage boy or a young girl - because it is no secret that girls tend not to fully understand the consequences of such behavior, which can lead to negative results.

Well maintained appearance, age over 25 years, a calm voice and lack of nervousness in behavior with an 80% probability will ensure the acquisition of any prescription drug even in the absence of a paper prescription in hand.

Fluoxetine in popular culture

In 2001, the film Prozac Nation was made, the heroine of which is a young journalist who takes Prozac (the trade name of an antidepressant produced by Eli Lilly based on the active ingredient fluoxetine) in order to cope with depression.
Tony Soprano, one of the main characters in the crime series The Sopranos, takes Prozac
In 2010, the film “Love and Other Medicines” was released. main character which works medical representative and is actively involved in the competition between the antidepressants Prozac (fluoxetine) and Zoloft (sertraline) belonging to the same group.

Systematic use of this drug helps patients overcome apathy, improve mood, normalize appetite and sleep, and reduce feelings of fear and tension.

First acquaintance with the medicine

The active ingredient of the drug is fluoxetine hydrochloride.

The pharmacological properties of Fluoxetine are based on its ability to inhibit the reuptake of serotonin into the central nervous system, the main neurotransmitter called the hormone of pleasure (or happiness).

It is he who is responsible for a good mood, the absence of tearfulness, pickiness, and boredom. The therapeutic effect of the drug improves the patient’s psycho-emotional activity and does not affect blood pressure, functional activity of the heart, and does not cause drowsiness or lethargy.

The drug is prescribed for:

Pros and cons of the drug

The main advantages of the drug are:

lack of hypnotic effect and cardiotoxic effect;
availability in the pharmacy network;
democratic price.

The disadvantages of the drug include the following side effects:

dizziness and headache;
asthenia;
increased sweating;
decreased libido;
the appearance of pain in the bones and mammary glands;
noise in ears;
stool instability;
rashes on the skin;
dry mouth;
disturbances of taste and olfactory sensations;
decreased vision.

allergic reaction to the main component of the drug;
pregnancy;
breastfeeding the baby;
pathological processes in the liver and kidneys;
diabetes mellitus;
epileptic conditions.

This predominance of “minuses” over “pluses” is a consequence of the fact that this medicinal product already outdated. Today, the pharmacological industry provides patients with modern analogs of Fluoxetine, which have the ability to selectively affect the human body.

Why do people look for fluoxetine analogs?

Price issue

Fluoxetine is not the cheapest drug (its price is about 300 rubles) and in order to save money you have to look for more affordable analogues.

Among them are Framex and Flunat - these are more affordable medications that cost from 100 to 150 rubles, and their low price is due to their less famous name.

By-effect

Fluoxetine is a high-quality and proven drug, but it has certain disadvantages, or rather a number of side effects:

bowel dysfunction;
infrequent headaches that appear an hour after administration;
increased heart rate, which can lead to tachycardia;
overdrying of the mucous membrane;
blurred vision;
increased sweat secretions;
general malaise;
Women who took the drug experienced pain in the mammary glands and menstrual irregularities (up to several weeks);
nausea and vomiting;
noise in ears;
constant feeling of fatigue;
sleep disorders;
depression;
acne and allergic irritations;
broken bones;
sexual apathy (loss of interest in sex).

The list of contraindications is quite long and that is why most people are looking for more harmless analogues. For example, it could be Flunat or Deprex. The drugs have a natural composition and a less aggressive effect on the patient’s body.

No choice

Of course, the last reason why people turn to analogues of this drug is simply its absence on the shelves in pharmacies, since Fluoxetine is a sought-after medication.

If this medicine is not available in the pharmacy, then you should turn your attention to Profluzac and Fluval, which are identical in their action and composition.

Analogues in terms of active substance, composition, action

The active substance fluoxetine hydrochloride has the following analogues:

Apo-Fluoxetine;
Bioxetine;
Deprex;
Deprenon;
Flunate;
Fluval;
Fluoxetine-Canon;
Fluoxetine-Nycomed.

Similar medications in composition and effects on the body:

Portal, composition: fluoxetine and vitamin supplements;
Prodep, composition: fluoxetine and calcium;
Prozac, composition: fluoxetine and sedatives.

Unlike fluoxetine, almost all similar drugs have fewer impurities in their composition, which means they are more harmless.

TOP - 15 best analogues

Apo-Fluoxetine is an antidepressant that has a calming effect and improves mood;
Bioxetine is a fairly effective selective inhibitor; it is often prescribed for neuroses, since it has practically no side effects;
Deprex is a product that contains the active substance fluoxetine, which has a sedative and invigorating effect for neuralgia;
Deprenon is a potent depressant (prescribed for serious mental disorders);
Portal is an antidepressant in capsule form, which, thanks to natural composition has proven itself well as a medicine in the fight against bulimia nervosa;
Prodep is an antidepressant, a selective serotonin reuptake inhibitor, which improves mood, reduces tension, anxiety and fear;
Prozac is a natural medicine used for depression (regardless of the degree of depressive disorder - mild, moderate, severe), bulimia, anorexia, alcoholism, obsessive-compulsive disorder;
Profluzak is a strong antidepressant used in the fight against psychological and nervous conditions;
Flunate is an adjuvant drug based on fluoxetine, which enhances the effects of Alprazolam, Diazepam and ethanol;
Fluval is not the most popular, but nevertheless a worthy analogue of Fluoxetine, which is used in conjunction with electroconvulsive therapy;
Framex is an antidepressant that should only be taken under medical supervision, since when used together with other medications it can increase blood concentration, which can lead to adverse consequences;
Fluoxetine-Canon is a potent sedative used for violent nervous disorders;
Phloxet – complete analogue Fluoxetine, which is used for depressed state and other disorders;
Fluoxetine-Lannacher is a selective inhibitor that is used for bulimia nervosa and anorexia;
Fluoxetine - Nycomed is a sedative based on the parent medication.

A question of price and free access

Cheap analogues of the antidepressant Fluoxetine:

fluoxetine analogs without prescriptions

In the section Diseases, Medicines, the question is: what analogues of fluoxetine are there? (Prozac) asked by the author Marina Ruban, the best answer is there is also a rather expensive analogue with the commercial name Framex. However, if your pharmacy does not have fairly cheap Fluoxetine, then Prozac or Framex are unlikely to be there. Good luck!

Primary source higher medical education

Fluoxetine - Russian drug. Maybe it didn’t go through the Ukrainian Pharmaceutical Committee?

Look for Prozac or Framex. Let the doctor rewrite the prescription

What is fluoxetine

Fluoxetine, also known by the trade name Prozac, is one of the most popular antidepressants belonging to the group of selective serotonin reuptake inhibitors.

A detailed academic article about this drug can be read on Wikipedia.

How fluoxetine works

The principle of action of fluoxetine can be presented in a highly simplified form, “on the fingers”, as follows.

The incoming flow can be increased in a variety of ways - for example, systematic exercise or eastern health practices, meditation. The problem is that often a person lacking serotonin does not have the strength to force himself to do this, and then wait for the results.

Another way to increase the incoming flow is to drink alcoholic beverages. When alcohol enters the body, it causes a sharp release of serotonin, which improves mood, internal stiffness disappears, and life begins to seem more pleasant and colorful for a while. And then the intoxication passes, the level of serotonin drops back, and the need to repeat occurs. The negative impact of alcohol on the ability to think and its general destructive effect on the body is obvious to everyone, but, unfortunately, for many people, alcohol abuse is the only known and tested effective way to somehow maintain their psycho-emotional state.

In more scientific language, the principle of action of fluoxetine and other SSRI drugs is described in the instructions for them, and is more clearly shown in the video below.

Preparations containing fluoxetine

There are currently many fluoxetine-based antidepressants available in the market under different brand names.

Prozac
Prodep
Profluzak
Fluval
Fluoxetine
Fluoxetine-Acree
Fluoxetine-Canon
Fluoxetine Hexal
Flunisan
Fluoxetine hydrochloride
Fluoxetine Lannacher
Apo-Fluoxetine
Fluxen

The best fluoxetine-containing drug

Which of the drugs available on the market is the best? In fact, this is a difficult question, because all of them are based on the same active substance - fluoxetine, and it is not clear how, apart from the trade name, one drug differs from another. Therefore, it is recommended to start with one of the two most common brands in Russia - Fluoxetine-Canon or Fluoxetine Lannacher. Both drugs have many positive reviews. In rare cases, it may turn out that the purchased drug is subjectively “not yours” - this is completely normal, and in such a situation it is worth trying to simply change fluoxetine from one brand to another.

And in order not to feel the agony of choice, you can immediately give preference to Prozac - the oldest drug based on fluoxetine, which was brought to the market by Eli Lilly, which originally discovered and registered the substance fluoxetine in 1974. The only disadvantage of Prozac is its higher cost compared to analogues.

Fluoxetine analogues

Analogs of fluoxetine include other antidepressants from the SSRI group.

Their action is based on the same principle, but different active ingredients. In case of individual intolerance to fluoxetine or insufficient effect, it is necessary to try other drugs.

In no case should you start taking a new SSRI drug less than 2 weeks after stopping the previous SSRI drug or MAO inhibitor antidepressants. Ignoring this prescription will lead to the fact that the interactions of several different active substances of the SSRI group will overlap each other, which can provoke serotonin syndrome - a very unpleasant and potentially fatal phenomenon.

useful links

Prescription for fluoxetine

Can I buy fluoxetine without a prescription?

How to buy fluoxetine without a prescription

To purchase fluoxetine without a prescription, you need to give the impression of a sane adult who controls himself and understands what he is doing.

It should be understood that the decision to dispense a particular drug without a prescription is primarily a matter of morality. Therefore, it is likely that a pharmacy pharmacist will want to refuse to sell to a person who outwardly can be mistaken for a teenage boy, or to a young girl - because it is no secret that girls tend to abuse fluoxetine for the purpose of losing weight and are not fully aware of the consequences of such behavior, which can lead to negative results.

Well-groomed appearance, age over 25 years, a calm voice and absence of nervousness in behavior will with an 80% probability ensure the purchase of any prescription drug, even in the absence of a paper prescription in hand.

FLUOXETINE analogues

We kindly ask you not to make a decision to replace FLUOXETINE on your own, only as directed and with the permission of your doctor.

(160 offers from 13 to 36 UAH)

Price update date: 2 hours 13 minutes ago

HELARIUM HYPERICUM

Gelarium Hypericum is also used in the treatment of patients with various psychovegetative disorders, which are accompanied by apathy, emotional depression, causeless anxiety, irritability and restlessness.

The drug can be prescribed for asthenoneurotic syndrome.

LOTUSONIC

increased nervous excitability,

emotional or physical trauma,

states of constant mental stress or overexertion,

the so-called "manager syndrome"

insomnia (mostly mild forms).

DYSTONICUM

In the case of athletes, it improves physical performance and improves oxygen circulation in muscle fibers.

In the case of psychological and emotional states which can lead to depression, sadness, melancholy, weakness, moral instability, loss of libido and appetite. During recovery from illness or surgery. Also helps relieve asthenic effects caused by long-term use of antibiotics or chemotherapy.

To improve the condition of alopecia, peeling skin, depleted nails, cracked feet and very dry skin.

HOMVIO-NERVIN

Neuroses, nervous excitement: trembling in the body, fear, dizziness;

Insomnia due to mental and physical fatigue;

Depressive states mild degree heaviness;

Neurocirculatory dystonia, migraine;

Senile tremor, unsteady walking, forgetfulness, parkinsonism;

Neurotic, psychotic and autonomic disorders with age-related changes hormonal levels (menopause in women and men, puberty in adolescents);

Itching of the skin and genitals; - arterial hypertension, chronic ischemic disease heart (as part of combination therapy).

AZAFEN

5 HTP Power (5-hydroxytryptophan)

Obsessive-compulsive neurosis;

Hyperactivity syndrome (attention deficit in children);

Pain syndromes (including fibromyalgia);

Chronic fatigue syndrome;

NEUROL

VALDOXAN

ADEPRESS

NEUROPLANT

A-DEPRESSIN

ACTAPAROXETINE

Depression of all types, including reactive, severe endogenous depression and depression accompanied by anxiety;

Obsessive-compulsive disorder (OCD);

Panic disorder, including agoraphobia;

Social anxiety disorder/social phobia;

Generalized anxiety disorder;

Treatment for Post-Traumatic Stress Disorder

CITOL

GERFONAL

ZALOX

Major depressive episodes.

Preventing relapse of major depressive episodes.

Panic disorders with or without agoraphobia.

Obsessive-compulsive disorder (OCD) in adults and children 6-17 years old.

Social anxiety disorder.

Post-traumatic stress disorder (PTSD).

SERTRALOFT

SERENATA

REMERON

BIOTON

FEVARIN

MIRTAZINE

TRITTICO

LIFE 900

Seroquel

COAXIL

SEVPRAM

Depressive episodes of any severity.

Panic disorders with/without agoraphobia.

Social anxiety disorder (social phobia).

Generalized anxiety disorder.

AMITRYPTYLINE

CYMBALTA

Cymbalta is also used in the treatment of peripheral diabetic neuropathy (with severe pain).

VELAXIN

SIRLIFT

MELITOR

VAMELAN-N

Depressive and anxiety disorders

Neuroses (including those accompanied by tachycardia and cardialgia)

Increased excitability, including skin diseases, pain, injuries and burns (as part of complex therapy)

initial stage arterial hypertension(as part of complex therapy)

DELTALICIN

At pathological conditions central and peripheral nervous system: meningitis, encephalitis of any origin, neuritis, radiculitis, paresis, stroke, multiple sclerosis, traumatic brain injury, cerebral palsy.

At emergency: shock of any origin.

In gerontological practice: to eliminate syndromes of dyscirculatory encephalopathy of atherosclerotic origin (for headaches, heaviness and noise in the head, irritability, emotional imbalance, dysphoria and sleep disorders).

In neurological practice: with memory loss, mental performance and other intellectual and mental disorders;

In drug treatment practice: as a means to relieve alcohol withdrawal syndrome and primary pathological craving for alcohol.

The drug is most effective in the presence of vegetative and affective manifestations(subdepressive and dysphoric).

For intoxication: alcohol, drugs, iatrogenic, including in cases of high-dose chemotherapy.

For diseases of the cardiovascular system: atherosclerosis, hypertension, coronary heart disease, angina pectoris, arrhythmias, myocarditis.

Fluoxetine

Description current as of 09/02/2015

Latin name: Fluoxetine
ATX code: N06AB03
Active ingredient: Fluoxetine
Manufacturer: ALSI Pharma, Obolenskoe, ZiO-Zdorovye, Biocom CJSC, Ozon LLC (Russia), LLC Pilot Plant GNTsLS (Ukraine)

Compound

Fluoxetine tablets contain 20 mg of fluoxetine, as well as lactose monohydrate, gelatin, corn starch, calcium stearate, povidone, silicon (Si) colloidal dioxide, talc, light magnesium (Mg) carbonate, tropeolin 0, additive E171 (titanium (Ti) dioxide), mineral oil, sugar, yellow wax.

Release form

Yellow film-coated tablets in blisters of 10 pieces, 1 or 2 blisters per package.

pharmachologic effect

The drug has an anorexigenic effect, eliminates depression and relieves feelings of depression.

Pharmacodynamics and pharmacokinetics

The substance fluoxetine - what is it?

The active substance of the drug fluoxetine hydrochloride is a white (or almost white) crystalline powder, sparingly soluble in water.

What is Fluoxetine?

Fluoxetine is a selective serotonin reuptake inhibitor (SNRS). The drug belongs to the pharmacotherapeutic group “Antidepressants”.

Pharmacodynamics

The medicine is intended for oral administration. The mechanism of its action is associated with the ability to selectively (selectively) and reversibly inhibit ONZS.

The antidepressant Fluoxetine has little effect on the uptake of dopamine and norepinephrine and has a weak effect on acetylcholine receptors and H1-type histamine receptors.

Along with antidepressant, it also has a stimulating effect. After taking the tablets/capsules, the patient’s feelings of fear, anxiety and mental tension decrease, mood improves, and symptoms of dysphoria are eliminated.

Wikipedia notes that the drug does not cause orthostatic hypotension, does not have a sedative effect, and is not cardiotoxic.

It takes 3 to 4 weeks to achieve a lasting clinical effect with regular use of the drug.

Pharmacokinetic parameters:

absorption in the digestive canal is good;
bioavailability - 60% (orally);
TSmax - from 6 to 8 hours;
binding to plasma proteins (including alpha (α)-1-glycoprotein and albumin) - 94.5%;
T½hour.

The liver is involved in the metabolism of the substance. As a result of its biotransformation, a number of unidentified metabolites are formed, as well as norfluoxetine, the selectivity and activity of which are equivalent to those of fluoxetine.

Pharmacologically inactive metabolic products are eliminated by the kidneys.

Due to the fact that the substance is excreted from the body rather slowly, the plasma concentration necessary to maintain the therapeutic effect is maintained for several weeks.

Indications for use: why are tablets and Fluoxetine prescribed?

Indications for use of Fluoxetine:

depression (especially accompanied by fears), including when other antidepressants are ineffective;
obsessive-compulsive disorder (OCD);
kinorexia (to reduce uncontrollable cravings for food, the drug is used as part of complex psychotherapy).

Contraindications

The drug is not prescribed for:

* After using MAO inhibitors, Fluoxetine can be used no earlier than 14 days later; MAO inhibitors after completion of treatment with Fluoxetine are prescribed no earlier than 5 weeks later.

Side effects of Fluoxetine

General disorders that occur during the use of the drug can manifest themselves in the form of hyperhidrosis, chills, fever or sensation of cold, photosensitivity, neuroleptic syndrome, alopecia, lymphadenopathy, anorexia, erythema multiforme, which can progress to malignant exudative or develop into Lyell's syndrome.

Some patients experience symptoms of serotonin toxicity, including:

From the outside digestive system organs possible: diarrhea, nausea, loss of appetite, vomiting, dysphagia, dyspepsia, change in taste, pain in the esophagus, dry mouth, dyskinesia, liver dysfunction. In isolated cases, idiosyncratic hepatitis may develop.

CNS reactions to taking pills manifest themselves in the form of: bruxism, headache, weakness, sleep disturbances (night delirium, pathological dreams, insomnia), dizziness, fatigue (hypersomnia, drowsiness); disturbances of attention, processes and concentration of thinking, memory; anxiety and associated psychovegetative syndrome, dysphemia, panic attacks, suicidal thoughts and/or attempts to take one's own life.

The possibility of developing:

Discontinuation of drug treatment may provoke withdrawal syndrome, the main symptoms of which are: sensitivity disorders, dizziness, sleep disorders, asthenia, nausea and/or vomiting, agitation, headache, tremor.

Reviews about side effects indicate that the drug, when taken uncontrolled, is addictive. In some cases, the addiction is so strong that a person requires professional help to treat it.

Other adverse reactions that patients mention in reviews are severe drowsiness, tremors, convulsions, loss of appetite, and nausea. However, there are people who did not experience any unwanted effects at all during treatment.

Instructions for use of Fluoxetine

The tablets are taken orally. Eating does not affect the absorption of the drug.

To relieve depressive symptoms, the medicine should be taken once a day, in the morning, at a dose of 20 mg. If clinically necessary, 3-4 weeks after the start of therapy, the frequency of doses is increased to 2 times per day. (tablets are taken morning and evening).

For patients with an insufficient response to treatment at a dosage of 20 mg/day, in some cases the daily dose is gradually increased. In this case, it should be divided into 3-4 doses. The highest dose for elderly and old age- 60 mg/day.

Dosage for bulimic neurosis - 60 mg/day. (take one tablet 3 times a day), for OCD - depending on the severity of clinical symptoms - from 20 to 60 mg/day.

It must be taken into account that increasing the dose may increase the severity of side effects.

Maintenance dose - 20 mg/day.

When does the drug start working?

A significant improvement in the condition is usually observed after about 2 weeks of systematic use of the medicine.

How long should I take Fluoxetine?

It takes six months to eliminate depressive symptoms.

For obsessive manic disorders (OMD), the drug is given to the patient for 10 weeks. Further recommendations depend on the results of treatment. If there is no clinical effect, the fluoxetine treatment regimen is reviewed.

If there are positive dynamics, therapy is continued using an individually selected minimum maintenance dose. The patient's need for further treatment should be reassessed periodically.

Long-term - more than 24 weeks in patients with NMR and more than 3 months in patients with bulimia nervosa - has not been studied.

After completion of treatment with Fluoxetine, the active substance circulates in the body for another 2 weeks, which should be taken into account when stopping treatment or prescribing other medications.

Patients with liver/kidney dysfunction, elderly people with concomitant diseases, as well as patients taking other medications, are prescribed half the dose of the drug. In some cases, it is advisable to transfer the patient to intermittent treatment.

If, after reducing the dose/discontinuing the drug, the patient's condition worsens, it is necessary to return to treatment with the previous effective therapeutic dose. A gradual dose reduction is resumed after positive dynamics appear.

If we compare Fluoxetine and Fluoxetine Lannacher or Fluoxetine and Fluoxetine OZONE, we can conclude that the instructions for use of Fluoxetine Lannacher and Fluoxetine OZONE contain recommendations similar to those listed above.

Overdose

An overdose of Fluoxetine is accompanied by: nausea/vomiting, convulsions, hypomania, anxiety, agitation, grand mal seizures.

A victim of an overdose should rinse the stomach, give sorbitol, enterosorbent and, for convulsions, diazepam. Monitoring of respiratory activity and parameters characterizing functional state hearts. Subsequently, symptomatic and supportive therapy is carried out.

Interaction

Doubles the plasma concentration of tricyclic antidepressants, phenytoin, trazodone, maprotiline. When prescribing Fluoxetine in combination with tricyclic antidepressants, the dose of the latter should be reduced by 50%.

It may provoke an increase in the plasma concentration of Li+, which in turn increases the likelihood of developing its toxic effects. In case of simultaneous use, it is recommended to monitor the concentration of Li+ in the blood.

Use as an adjunct to electroconvulsive therapy may cause the development of prolonged epileptic seizures.

The serotonergic effects of the drug are enhanced in combination with tryptophan. The likelihood of developing serotonin intoxication increases if taken simultaneously with drugs that inhibit the MAO enzyme.

The likelihood of adverse reactions and increased depressant effects on the central nervous system increases in combination with drugs that depress the central nervous system.

Taking with drugs that are characterized by a high degree of protein binding may provoke an increase in the plasma concentration of unbound (free) drugs, as well as an increase in the likelihood of developing undesirable effects.

Terms of sale: how is Fluoxetine dispensed - with a prescription or not?

Fluoxetine cannot be purchased without a prescription.

Storage conditions

Tablets should be stored at temperatures below 25°C.

Best before date

special instructions

When treating patients with low body weight, anorexigenic effects should be taken into account when prescribing the drug.

Diabetics may develop hypoglycemia during treatment with Fluoxetine, and hyperglycemia after discontinuation of the drug. Taking this into account, it is recommended to make changes to the dosage regimen of insulin and/or oral hypoglycemic agents. Before improvement clinical picture patients with diabetes mellitus must be under constant medical supervision.

During the treatment period, it is necessary to refrain from engaging in activities that require high speed psychomotor reactions and increased attention.

The tablets contain lactose, so they should not be taken if you have galactosemia, lactase deficiency, or glucose/galactose malabsorption syndrome.

Like other antidepressants, fluoxetine may cause affective disorders(mania or hypomania).

The central organ of drug metabolism is the liver; the kidneys are responsible for excreting metabolites. Patients with liver pathologies should be prescribed low or alternative daily doses.

At renal failure(with Clcr less than 10 ml/min.) after 2 months of treatment using a dose of 20 mg/day. plasma concentrations of fluoxetine/norfluoxetine are the same as in patients with healthy kidneys.

Depression is associated with an increased risk of suicidal ideation and suicide attempts. The risk remains until complete remission. Clinical experience with the drug shows that the risk of suicide increases, as a rule, by early stages recovery.

Patients with mental illness and depressive syndrome should be under constant supervision. In placebo-controlled studies in a group of patients receiving antidepressants, it was found that the risk of suicidal behavior is highest in people under 25 years of age.

Patients who have been switched to a lower/higher dose also require special monitoring.

The use of Fluoxetine is associated with the development of akathisia, the subjective symptoms of which are a constant need to be in motion, as well as the inability to sit or stand. These phenomena are especially pronounced in the first weeks of treatment. For patients who have developed such symptoms, the drug is prescribed in the minimum effective dose.

If discontinued suddenly, approximately 60% of patients develop withdrawal symptoms. The likelihood of their occurrence depends on the dose used, the duration of the course, and the level of dose reduction. It is recommended to reduce the dose by titration over 7-14 days.

There are reports of subcutaneous hemorrhages, such as purpura or ecchymosis, occurring during treatment with the drug. Therefore, for patients taking oral anticoagulants that affect platelet function and increase the likelihood of bleeding, as well as for patients with a history of bleeding, Fluoxetine is prescribed taking into account the possible risks.

Fluoxetine analogs

Which is better: Prozac or Fluoxetine?

The active ingredient in Prozac is fluoxetine. Therefore, when choosing in favor of one or another means decisive factors are price and subjective feelings. The cost of Fluoxetine is significantly lower than the cost of its analogue.

For children

Not used to treat patients under 18 years of age.

Nineteen weeks clinical trial showed that in children aged 8-18 years suffering from depression, the use of Fluoxetine causes a decrease in height and body weight. The effect of the drug on achieving normal growth in adulthood has not been studied.

However, the possibility of growth retardation during puberty cannot be ruled out.

Fluoxetine and alcohol

Drinking alcohol during treatment with Fluoxetine is contraindicated.

Fluoxetine for weight loss

Fluoxetine is often prescribed for bulimic syndrome - mental syndrome, which is accompanied by a lack of satiety and uncontrolled overeating.

The use of the drug reduces appetite and relieves the constant feeling of hunger.

Thus, we can conclude that to get rid of excess weight Fluoxetine can only be used if the reason for its intake is appetite.

However, the drug is not intended for weight loss; its main purpose is to treat depression. Decreased appetite and weight loss are side effects.

The medicine is quite powerful, and the body often reacts to its intake anaphylactic reactions and systemic disorders involving pathological process lungs, skin, kidneys and liver.

How to take Fluoxetine for weight loss?

At the initial stage, diet pills are taken in a minimal dosage - one once a day. If well tolerated, you can switch to taking two tablets - one is taken in the morning, the second in the evening.

The maximum permissible dose is 4 tablets/day.

The drug begins to act after 4-8 hours; it takes about a week to remove fluoxetine from the body.

International name

Fluoxetine

Group affiliation

Antidepressant

Dosage form

Capsules

pharmachologic effect

Antidepressant, selective serotonin reuptake inhibitor.

Improves mood, reduces tension, anxiety and fear, eliminates dysphoria. Does not cause orthostatic hypotension, sedation, and is noncardiotoxic.

A lasting clinical effect occurs after 1-2 weeks of treatment.

Indications

Depression (regardless of the degree of depressive disorder - mild, moderate, severe), bulimia, anorexia, alcoholism, obsessive-compulsive disorder.

Contraindications

Hypersensitivity, chronic renal failure (creatinine clearance less than 10 ml/min), severe liver failure, suicidality, simultaneous use of MAO inhibitors (in the previous 2 weeks), pregnancy, lactation. With caution. Diabetes mellitus, epileptic syndrome of various origins and epilepsy (including a history), Parkinson's disease, compensated renal and/or liver failure, cachexia.

Side effects

From the nervous system: dizziness, headache, drowsiness or insomnia, lethargy, increased fatigue, asthenia, tremor, agitation, anxiety, suicidal tendencies (typical of patients with depressive disorders), mania or hypomania.

From the digestive system: loss of appetite, dry mouth or hypersalivation, nausea, diarrhea.

Allergic reactions: skin rash, urticaria.

Other: increased sweating, weight loss, decreased libido, systemic disorders of the lungs, kidneys or liver, vasculitis.

Application and dosage

Orally, for depression, the initial dose is 20 mg/day 1 time, in the morning; if necessary, the dose is increased weekly by 20 mg/day. The maximum daily dose is 80 mg in 2-3 doses.

For bulimia and for elderly patients – 60 mg in 3 doses, for obsessive disorders – 20-60 mg/day. Maintenance therapy – 20 mg/day. The course of treatment is 3-4 weeks.

special instructions

When treating patients with underweight, anorexigenic effects should be taken into account (progressive weight loss is possible).

In patients with diabetes mellitus, the use of fluoxetine increases the risk of developing hypoglycemia and hyperglycemia when it is discontinued. In this regard, the dose of insulin and/or any other hypoglycemic drugs used orally should be adjusted. Until significant improvement in treatment occurs, patients should be under medical supervision.

During treatment, you should refrain from taking ethanol and engaging in potentially hazardous activities that require increased attention and speed of mental and motor reactions.

The interval between the end of therapy with MAO inhibitors and the start of treatment with fluoxetine should be at least 14 days; between the end of treatment with fluoxetine and the start of therapy with MAO inhibitors - at least 5 weeks.

For liver diseases and in old age, treatment should begin with 1/2 dose.

Interaction

Enhances the effects of alprazolam, diazepam, ethanol and hypoglycemic drugs.

Increases the plasma concentration of phenytoin, tricyclic antidepressants, maprotiline, trazodone by 2 times (it is necessary to reduce the dose of tricyclic antidepressants by 50% when used simultaneously).

During electroconvulsive therapy, prolonged epileptic seizures may develop.

Tryptophan enhances the serotonergic properties of fluoxetine (increased agitation, motor restlessness, gastrointestinal disorders).

MAO inhibitors increase the risk of developing serotonin syndrome (hyperthermia, chills, increased sweating, myoclonus, hyperreflexia, tremor, diarrhea, incoordination, autonomic lability, agitation, delirium and coma).

Drugs that have a depressant effect on the central nervous system increase the risk of side effects and increased depressive effects on the central nervous system.

When used simultaneously with drugs that have a high degree of protein binding, especially with anticoagulants and digitoxin, it is possible to increase the plasma concentration of free (unbound) drugs and increase the risk of adverse effects.

Reviews of the drug Fluoxetine: 7

I've been taking this medication for over a month now and it seems to be helping with my depression. But I would not advise anyone who has signs of depression to take it. In general, writing reviews regarding any medicine is not entirely correct and possibly dangerous. After all, everyone’s body is individual, which means the selection of the drug should also be individual. Reviews are appropriate for ordinary products, but not for tablets, this is too much.

I’ve been drinking Flu for 2 months.... I started sleeping soundly... I don’t know if this is good or bad, but I sleep during the day and at night when I’m pregnant... but I sleep great... and everything else is fine... I’ve lost weight since I was 57 up to 49 in a month... by the evening you are so energetic)) but it’s better not to wake you up in the morning, it’s useless...

I've read about the side effects and I'm scared to drink. 1 capsule in the morning I can sleep better and feel calmer. My head feels a little dull, as if I’m slowing down. I take it along with carbamazepine as prescribed by the doctor. Diagnosis of VSD

Anyone who has depression due to being overweight is totally cool!! Let's kill two birds with one stone.

Everything would be fine, but I just don’t want to have sex with him ((

They prescribed 10 mg 1/day (I have problems with muscle regulation: they either relaxed or contracted, and the disturbances occurred after taking 1 tablet of a muscle relaxant and a tablet of AD-Velafax). We waited for almost a year for it to go away, but... I took it for 4 days, half a day, because... I have a weight of 44 kg and intolerance to all neurological “delights”. Scheme 1 dose of 2.5 mg - the larynx was compressed, a so-called “lump in the throat” appeared, then the limbs relaxed so much that there was a feeling that the arms were amputated to the shoulder area and , most importantly, tightness, burning and abs in the head. The 2nd appointment went better. On the 3rd appointment I decided to increase it to 5 mg - it was simply terrible: again a sharp relaxation of the muscles of the body, limbs, and my head was so squeezed that I suffered for 2 days from terrible pain, and my face also tightened (pressure in the zygomatic region, pressure on the nose , eyes) and the jaws began to contract spontaneously. 3rd dose 2.5 mg is almost the same, but there is a sleep disorder and the jaw is compressed as if from bruxism. Those. I felt worse. I’ll try to take it for 2 weeks (according to the number of doses) with seduxen, but if seduxen doesn’t remove the side effects in the form of clenched jaws and spasms of my healthy internal organs, the smell of fried food began to make me sick, then I’m afraid I’ll have to change it. It’s a shame, because they selected my blood pressure using the Foll method, because They realized that my tolerance was pretty bad.

Anastasia, January 26, 2017, age: 16

I took fluoxetine for about 2 months with the goal of losing weight. So I lost 10 kg. The volumes dropped very sharply. I’m very glad, but these 2 months were very difficult, as I slept all day long and it was impossible to get me up.

Write your review

Do you use Fluoxetine as an analogue or vice versa its analogues?

Fluoxetine-based drugs are prescribed to treat not only depression, but also many other comorbid disorders. However, sometimes the question arises of what can replace Fluoxetine capsules, and it is not possible to quickly consult a doctor. In this article we will talk about modern analogues Fluoxetine and features of their use.

Brief description of the medicine

Fluoxetine is an antidepressant that belongs to the group of serotonin reuptake inhibitors (the main “happy hormone” in our body). This means that it increases the concentration of the hormone in the nervous tissue and improves the psycho-emotional state of the patient. The medicine is prescribed for:

depression;
obsessive-compulsive disorders (obsessive states);
early ejaculation in men;
bulimia (overeating in stressful situations);
mood disorders in women during menstruation or menopause.

Why do people look for fluoxetine analogs?

There are situations when you have to quickly look for an adequate replacement for Fluoxetine: when the medicine is not at hand or its use is impossible for some reason.

Price issue

Fluoxetine cannot be classified as an expensive drug. A drug Russian production can be found at a price of 30-50 rubles for 20 capsules. However, they are not always available in pharmacies, and imported synonyms of domestic Fluoxetine cost many times more.

Side effects

The main problem when taking Fluoxetine is the risk of developing severe side effects. Among them:

overexcitement, insomnia;
hand tremors, convulsions;
nausea, vomiting, diarrhea;
suicidal tendencies;
headaches, balance problems;
loss of appetite, weight loss;
decreased sex drive;
menstrual irregularities;
allergic reactions.

There are analogues for correction depressive disorders, which are less likely to cause side effects, although this primarily depends on the individual sensitivity of the body to the active substance.

Lack of the drug in pharmacies

Fluoxetine is usually available in pharmacies. However, due to the high demand and affordable price, the cheapest antidepressant options are quickly sold out, leaving only the expensive Fluoxetine. In addition, small pharmacies rarely sell prescription drugs, which include Fluoxetine.

No prescription

Lack of a prescription is another one serious problem for patients requiring treatment with Floxetine. Even if a person receives an antidepressant on the recommendation of a doctor, he is not always able to come to the clinic on time to pick up a prescription. Sometimes you have to wait a month for an appointment with a doctor, but you need the drug right now. In such cases, you have to get out of the situation by buying over-the-counter substitutes for Fluoxetine.

How to replace Fluoxetine

Let us consider in more detail the main options for replacing Fluoxetine.

Analogs for the active substance

Direct analogues of Fluoxetine, which have almost identical instructions for use, are Prozac, Apo-Fluoxetine, Fluoxetine-Canon, Fluoxetine Lannacher. Fluoxetine Lannacher, Prozac and Apo-Fluoxetine are European analogues that differ more high quality. Prozac is the trade name of the original Fluoxetine, passed a full range of clinical trials and considered the safest. Its significant disadvantage is the high price - about 500 rubles. for 14 capsules.

Analogs by pharmacological group

Antidepressants - serotonin reuptake inhibitors also include Fevarin, Zoloft, Selectra, Serenata, Cipralex, Paxil. All of them are used in the treatment of depression, but they act differently on the body. Fevarin has a predominant calming effect, while Cipralex and Selectra (as well as Fluoxetine) have a stimulating effect. Balanced action typical for Paxil, Zoloft, Serenata.

Cheap substitutes

The most affordable analogues of Fluoxetine include:

Amitriptyline is the cheapest antidepressant, which differs from Fluoxetine in its mechanism of action and predominant sedative and hypnotic properties. The minimum cost of 50 tablets can be 25 rubles.
Sibazon and Phenazepam are tranquilizers, i.e. drugs that suppress anxiety. Despite the fact that antidepressants and tranquilizers have different purposes, in some cases they help relieve the same conditions. For example, both groups are effective for anxiety and depressive disorders, obsessive fears. The cost of 20 tablets of Sibazon usually does not exceed 30 rubles, 50 tablets of Phenazepam cost about 100 rubles.
Sedatives (sedatives) - tincture, extract of valerian, motherwort, St. John's wort, Dobrokam, Validol. The medications are taken off nervous tension, soothe, improve sleep. The effect is somewhat weaker than antidepressants, but with systematic application often help cope with light forms depression and anxiety disorders. All of the drugs listed are affordable.

Analogues without prescriptions

All synthetic antidepressants in Russia are sold with a prescription. Therefore, only their herbal analogues (Doppelhertz Nervotonic, Negrustin, Gelarium), freely available in pharmacies, can be classified as over-the-counter substitutes for Fluoxetine. They contain dry extract of St. John's wort, which also affects the exchange of serotonin and melatonin (a substance that normalizes sleep). Drugs in this group are used to treat mild or moderate depression, neurosis (mental instability), and low mood.

Plant-based sedatives (Persen, Dobrocam, Novo-Passit) can replace Fluoxetine in cases of anxious depression, obsessive-compulsive disorder, menopause and other changes accompanied by irritability and bad mood.

Conditional analogues of Fluoxetine, which can be bought without prescriptions, also include homeopathic sedatives: Tenoten, Neurosed, Calm. They contain microdoses of the active substance, therefore they are completely harmless and can be used in children's practice. However, the effectiveness homeopathic medicines not scientifically proven.

TOP best analogues

We present to your attention five best antidepressants, which can successfully replace Fluoxetine, and in some cases even perform better than it:

Selectra contains escitalopram as an active ingredient, which (like Fluoxetine) has a stimulating effect. Due to a narrower focus therapeutic effects Selectra is less likely to provoke adverse reactions, does not cause suicidal thoughts and can be used for depression of any severity.
Cipralex also includes escitalopram, but is characterized by more wide range actions. In addition to depression, it is prescribed for obsessive-compulsive, panic and anxiety disorders.
Paxil is indicated for the same conditions as Cipralex, although it contains a different active ingredient - paroxetine. The frequency of undesirable effects associated with its use is lower than that of Fluoxetine, but its negative effect on the fetus during pregnancy has been proven, whereas such risks have not been identified for Fluoxetine.
Valdoxan is an antidepressant that primarily acts on melatonin. It is used for all types of depression, normalizes sleep and is well tolerated. Valdoxan has no effect on cardiovascular system, genitourinary area, does not cause addiction or withdrawal symptoms.
Zoloft differs from Fluoxetine in its balanced effect on the nervous system - it does not cause obvious stimulation. Zoloft has more wide list possible adverse reactions than fluoxetine, but the actual frequency of their occurrence is lower.

pharmachologic effect

Antidepressant, propylamine derivative. The mechanism of action is associated with selective blockade of neuronal reuptake of serotonin into the central nervous system. Fluoxetine is a weak antagonist of cholinergic, adrenergic and histamine receptors. Unlike most antidepressants, fluoxetine does not appear to cause a decrease in the functional activity of postsynaptic β-adrenergic receptors. Helps improve mood, reduces feelings of fear and tension, eliminates dysphoria. Does not cause sedation. When taken in average therapeutic doses, it has virtually no effect on the functions of the cardiovascular and other systems.

Pharmacokinetics

Absorbed from the gastrointestinal tract. Poorly metabolized during the “first pass” through the liver. Food intake does not affect the degree of absorption, although it may slow down its rate. Cmax in plasma is achieved after 6-8 hours. Cmax in plasma is achieved only after continuous administration for several weeks. Protein binding 94.5%. Easily penetrates the BBB. Metabolized in the liver by demethylation to form the main active metabolite, norfluoxetine.

T1/2 of fluoxetine is 2-3 days, norfluoxetine is 7-9 days. 80% is excreted by the kidneys and about 15% through the intestines.

Indications

Depression of various origins, obsessive-compulsive disorders, bulimic neurosis.

Dosage regimen

Initial dose - 20 mg 1 time / day in the morning; if necessary, the dose can be increased after 3-4 weeks. Frequency of administration: 2-3 times/day.

Maximum daily dose when taken orally for adults is 80 mg.

Side effect

From the side of the central nervous system: possible anxiety, tremor, nervousness, drowsiness, headache, sleep disturbances.

From the digestive system: Possible diarrhea and nausea.

From the side of metabolism: increased sweating, hypoglycemia, hyponatremia are possible (especially in elderly patients and with hypovolemia).

From the outside reproductive system: decreased libido.

Allergic reactions: Possible skin rash and itching.

Others: pain in joints and muscles, difficulty breathing, increased body temperature.

Contraindications for use

Glaucoma, bladder atony, severe renal dysfunction, benign hyperplasia prostate gland, simultaneous administration of MAO inhibitors, convulsive syndrome of various origins, epilepsy, pregnancy, lactation, hypersensitivity to fluoxetine.

Use during pregnancy and breastfeeding

Contraindicated for use during pregnancy and lactation.

Use in children

Overdose

Symptoms: psychomotor agitation, seizures, drowsiness, disturbances heart rate, tachycardia, nausea, vomiting.

Other severe symptoms Overdoses of fluoxetine (both when taken alone and when taken concomitantly with other drugs) included coma, delirium, prolongation of the QT interval and ventricular tachyarrhythmia, including fibrillation - ventricular flutter and cardiac arrest, decreased blood pressure, syncope, mania, pyrexia , stupor and neuroleptic malignant syndrome-like condition

Treatment: Specific antagonists to fluoxetine have not been found. Symptomatic therapy is carried out, gastric lavage with the administration of activated charcoal, for convulsions - diazepam, maintenance of breathing, cardiac activity, body temperature.

Drug interactions

When used simultaneously with drugs that have a depressant effect on the central nervous system, ethanol may significantly enhance the depressant effect on the central nervous system, as well as increase the likelihood of developing seizures.

When used simultaneously with MAO inhibitors, furazolidone, procarbazine, tryptophan, the development of serotonin syndrome (confusion, hypomania, motor restlessness, agitation, convulsions, dysarthria, hypertensive crisis, chills, tremor, nausea, vomiting, diarrhea).

With simultaneous use, fluoxetine inhibits the metabolism of tricyclic and tetracyclic antidepressants, trazodone, carbamazepine, diazepam, metoprolol, terfenadine, phenytoin, which leads to an increase in their concentration in the blood serum, increasing their therapeutic and side effects.

With simultaneous use, it is possible to inhibit the biotransformation of drugs metabolized with the participation of the CYP2D6 isoenzyme.

When used simultaneously with hypoglycemic agents, their effect may be enhanced.

There are reports of increased effects of warfarin when used simultaneously with fluoxetine.

When used simultaneously with haloperidol, fluphenazine, maprotiline, metoclopramide, perphenazine, pericyazine, pimozide, risperidone, sulpiride, trifluoperazine, cases of the development of extrapyramidal symptoms and dystonia have been described; with dextromethorphan - a case of the development of hallucinations has been described; with digoxin - a case of increased concentration of digoxin in the blood plasma.

When used simultaneously with lithium salts, an increase or decrease in the concentration of lithium in the blood plasma is possible.

With simultaneous use, it is possible to increase the concentration of imipramine or desipramine in the blood plasma by 2-10 times (may persist for 3 weeks after discontinuation of fluoxetine).

When used simultaneously with propofol, a case was described in which spontaneous movements were observed; with phenylpropanolamine - a case is described in which dizziness, weight loss, and hyperactivity were observed.

With simultaneous use, it is possible to enhance the effects of flecainide, mexiletine, propafenone, thioridazine, zuclopenthixol.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

In a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children. Shelf life - 3 years.

Use for liver dysfunction

Use with extreme caution in patients with impaired liver function.

Use for renal impairment

Contraindicated in severe violations kidney function. Use with extreme caution in patients with moderate to mild renal impairment.

Use in elderly patients

special instructions

Use with extreme caution in patients with impaired liver and kidney function, a history of epileptic seizures, and cardiovascular diseases.

In patients with diabetes mellitus, changes in blood glucose levels may occur, which requires adjustment of the dosage regimen of hypoglycemic drugs. When used in weakened patients while taking fluoxetine, the likelihood of developing epileptic seizures increases.

With the simultaneous use of fluoxetine and electroconvulsive therapy, the development of prolonged epileptic seizures is possible.

Fluoxetine can be used no earlier than 14 days after discontinuation of MAO inhibitors. The period after discontinuation of fluoxetine before starting therapy with MAO inhibitors should be at least 5 weeks.

Elderly patients require dosage adjustment.

The safety of fluoxetine in children has not been established.

During the treatment period, avoid drinking alcohol.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, you should refrain from potentially hazardous activities that require increased attention and rapid psychomotor reactions.