Pain is a common problem in both adults and children. Sometimes they are caused by spasms of smooth muscles and then antispasmodics are used for treatment. One of the most famous drugs of this group can be called No-shpu. When is this medication prescribed to children and in what dose?
Release form
No-spa is presented in pharmacies in two forms:
- Pills, which are greenish-yellow or yellow-orange in color, have a convex round shape and have “spa” embossed on one side. Such tablets are packaged in blisters of 6, 10, 12 or 24 pieces, so one box sells from 6 to 30 tablets. In addition, the drug is produced in plastic bottles containing 60 or 100 tablets.
- Ampoules, containing a clear yellow-greenish solution, which is intended for injection into the muscle or for intravenous injections. One such dark glass ampoule holds 2 ml of medicine, and one pack contains 5 or 25 ampoules.
In addition, a drug called No-shpa forte is produced. Such tablets differ in shape (they are oblong), engraving on one side (they say “NOSPA”) and the amount of active ingredient (it is contained in a dose of 80 mg per 1 tablet). Otherwise, this medication is identical to No-shpa tablets, both in composition and in indications and warnings.
Compound
Main component both forms of No-shpa are drotaverine hydrochloride. One tablet contains this substance at a dose of 40 mg. The same amount of drotaverine is in one ampoule, that is, the amount of this ingredient in 1 ml is 20 mg.
Additionally, lactose monohydrate is present in the solid form of the drug, corn starch, talc, povidone and magnesium stearate. In addition to drotaverine, No-shpa solution for injection includes sterile water, 96% alcohol and sodium disulfite.
Operating principle
The main ingredient of No-shpa has a pronounced antispasmodic effect on smooth muscles. The result of this effect is the relaxation of smooth muscles that are located in the walls of the stomach and intestines, as well as in genitourinary tract and bile ducts. Thanks to this relaxation pain syndrome caused by spasm is eliminated.
The therapeutic effect is associated with the inhibition of a certain enzyme responsible for the contraction of smooth muscles in such organs.
In addition, No-shpa also has some effect on blood vessels, as a result of which they expand, which has a positive effect on the blood supply to tissues.
Tablets taken orally are quickly absorbed and begin to act in about 30 minutes. The effect after administering the solution intramuscularly appears after 3-5 minutes. The maximum amount of drotaverine is determined in the blood 45-60 minutes after administration. By combining with plasma proteins, the drug is transferred to smooth muscle cells. After complete metabolic transformation in the liver, the drug leaves the body mainly in urine and bile within 72 hours.
Indications
No-shpu is prescribed to eliminate spasms in the following pathologies:
- Cholecystitis.
- Cholangitis.
- Pericholecystitis.
- Cystitis.
- Gastritis.
- Biliary colic.
- Irritable bowel syndrome.
- Pyelitis.
- Enteritis.
- Spastic colitis.
- Intestinal colic.
- Peptic ulcer of the gastrointestinal tract.
In addition, the drug is prescribed for headaches, vomiting, dry cough (for example, for laryngitis, the medication is given before bed), as well as for toothache.
In this combination, for example, with Nurofen, No-shpa helps get rid of a fever that is dangerous for a child.
Terms of sale
No-shpu in tablets can be freely purchased at most pharmacies, since it is an over-the-counter medicine. average price 6 tablets cost 55-65 rubles, 24 tablets cost about 120 rubles, and for a bottle with 100 tablets you need to pay from 200 to 240 rubles. To purchase a solution for injections, you must first obtain a prescription from a doctor. On average, 5 ampoules of No-shpa cost 100 rubles.
Storage conditions
Storage of both tableted No-shpa and the solution in ampoules should be in a dry place at a temperature below +25 degrees. The shelf life of the solid form of the drug is 3 years or 5 years, the injectable form is 5 years.
No-shpa instructions
Instructions for use of the drug No-shpa, which is a myotropic antispasmodic, contains detailed description the drug, as well as instructions for its use for treatment.
No-spa composition, packaging, release form
The antispasmodic drug No-shpa is produced in the form of tablets for oral administration, and also as an injection solution that goes into medical institutions in ampoules.
No-spa tablets
No-shpa tablets have a round, biconvex shape, and are yellow in color, with a slight greenish or orange tint. One side of the tablet is engraved with “spa”.
The active substance of the drug is the substance drotaverine hydrochloride in the required concentration. It is supplemented with the required amount of magnesium stearate, talc, povidone, corn starch and lactose monohydrate.
The drug is supplied to the pharmacy chain in cardboard packs that contain various options packs of tablets. It can be:
- One PVC/aluminum blister containing 6 or 24 pieces;
- Two blisters of aluminum/aluminium, laminated with polymer, containing 20 pieces each;
- One polypropylene bottle each, which is equipped with a piece dispenser containing 60 pieces;
- One polypropylene bottle containing 100 pieces;
No-spa in ampoules
The No-shpa ampoule contains a transparent injection solution for intravenous and intramuscular injection, which has a greenish-yellow color.
The active ingredient of the drug is drotaverine hydrochloride in various concentrations. The solution is supplemented to the required amount with sodium disulfite, ethanol and water for injection.
It is supplied to pharmacies in cardboard packs containing one plastic blister pack containing five darkened glass ampoules with a break point for easy opening.
Storage period and conditions
The drug should be stored in a place inaccessible to children.
The shelf life of the drug, as well as the optimal temperature for this, depend on its packaging. Thus, No-spa in tablets, which are packaged in a PVC/aluminum blister, can be stored for up to three years at a temperature of no more than 25 degrees. Those tablets that are placed in an aluminum/aluminum blister are stored for no more than five years in rooms where the air temperature does not exceed 30 degrees. The drug in the form of tablets, packaged in a polypropylene bottle, as well as ampoules with solution, can be stored for up to five years, provided that the storage temperature is in the range from 15 to 25 degrees.
Pharmacology
Being an antispasmodic drug, No-shpa is capable of exerting a powerful effect on smooth muscles in order to relieve or reduce spasms. This becomes possible due to the fact that the drug has an inhibitory effect on the phosphodiesterase enzyme, resulting in inhibition of the enzymatic reaction with its participation.
The exchange reaction of cyclic adenosine monophosphate, which acts in the body as a secondary mediator in the intracellular distribution of hormonal signals in the smooth muscles of blood vessels and myocardium, occurs with the help of the third type PDE enzyme, due to which the high antispasmodic activity of the active substance of the drug No-shpa practically does not cause serious side effects with aspects of the cardiovascular system.
The active component of No-shpa, drotaverine, is effective against spasms of smooth muscles that are of neural or muscular origin. The substance also has a relaxing effect on smooth muscles. gastrointestinal tract, it has a similar effect on genitourinary system, as well as the bile ducts.
Pharmacokinetics
When taken orally, the drug is completely absorbed, and in a short period of time. About 65% of the dose taken appears in the systemic circulation. The maximum effect can be expected after three quarters of an hour.
Evenly distributed in tissues, drotaverine is able to penetrate deep into smooth muscle cells. The substance does not penetrate the blood-brain barrier. However, both drotaverine and its metabolites are capable of slight penetration through the placental barrier.
It has been established that the process of metabolism of drotaverine occurs almost completely in the liver during O-desethylation. The main accomplice in this is 4"-desethyldrotaverine, as well as 4"-desethyldrotaveraldine and 6-desethyldrotaverine.
The active substance of No-Spa is completely eliminated from the body within three days. Most of it is excreted through the kidneys, and the rest is removed into the bile through the intestines. Basically, drotaverine is excreted in a state of decay, since its unchanged form is not found in urine.
No-spa indications for use
The drug No-shpa is indicated for use for those patients who need to eliminate smooth muscle spasms in the presence of the following diseases:
Diseases of the biliary tract
- For cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis;
Diseases of the urinary system
- For nephrolithiasis, urethrolithiasis, pyelitis, cystitis, spasms Bladder, as well as for bladder tenesmus by injection.
The drug can also be prescribed as an auxiliary component in the treatment of diseases of the gastrointestinal tract accompanied by smooth muscle spasms:
- For ulcers duodenum and stomach, gastritis, enteritis, colitis, spastic colitis with constipation or irritable bowel syndrome with manifestations of flatulence. However, it is necessary to exclude those diseases in which the syndrome “ acute abdomen» for appendicitis, peritonitis, ulcer perforation, acute pancreatitis;
- For tension headaches in tablet form;
- For dysmenorrhea.
Contraindications
When prescribing No-shpa, one should take into account the presence of certain conditions in the patient for which the drug is contraindicated. Namely:
- At renal failure severe;
- In severe liver failure;
- For severe heart failure;
- IN childhood up to six years for taking the tablet form of the drug;
- It is undesirable to prescribe the drug in the form of injections in childhood, since clinical researches have not been carried out in this area;
- The drug should not be prescribed to a nursing woman, since there are no clinical trial data for this category of patients;
- In cases of rare hereditary galactose intolerance, lactase deficiency identified in the patient, with the syndrome hereditary disease malabsorption of glucose-galactose, the recommendation is given for the tablet form of the drug;
- At hypersensitivity to the components of the drug;
- In case of hypersensitivity to sodium bisulfite, the recommendation is given for the drug in the form of a solution;
The drug requires careful use for pregnant women, when used by children in the form of tablets and for those patients who suffer from arterial hypotension due to the risk of life-threatening a state called collapse.
No-spa instructions for use
The drug can be used without a doctor's prescription for one or two days. However, if pain relief cannot be achieved, you should immediately consult a doctor to clarify the diagnosis.
No-spa tablets
The daily oral dose for adult patients ranges from 120 to 240 milligrams. It should be divided into several parts. Single dose the drug should not exceed 80 milligrams, daily – 240 milligrams.
The first use of a bottle with a dispensing device involves removing the protective films from the top and bottom of the package.
No-shpa injections
If it is necessary to prescribe the drug for children, it is carried out in the following order:
For children from six to twelve years old, the daily dose is 80 milligrams, which should be divided into two parts.
For children over twelve years of age, the daily dose is 160 milligrams, which should be divided into two or four parts.
The daily dose for parenteral administration to adult patients ranges from 120 to 240 milligrams. It should be divided into several parts. A single dosage of the drug cannot exceed 80 milligrams, daily - 240 milligrams.
No-spa during pregnancy
Prescribing No-shpa for pregnant women is allowed only if urgent need, while avoiding the use of the drug in injection form. It is not recommended to use No-shpa during birth process for relax pain to avoid the risk of postpartum atonic hemorrhage.
Due to the fact that there is no confirmed data on the effects of the drug during breastfeeding, it is advisable for a woman not to use No-shpa for her treatment during this period.
No-shpa for children
Side effects
Side effects from taking the drug occur rarely and are short-lived.
The cardiovascular system
- In the form of a reduction blood pressure;
- In the form of rapid heartbeat;
Nervous system
- In the form of headaches;
- In the form of dizziness;
- In the form of insomnia;
Digestive system
- In the form of attacks of nausea;
- In the form of constipation;
The immune system
- Allergic reaction in the form of: angioedema, hives, itching; rash or local reactions in the form of redness at the injection site.
There are reports that some patients have developed anaphylactic shock, both with fatal, and without it.
No-spa overdose
Excessive use of the drug may interfere with heartbeat and conduction, a complete block of the bundle branches will occur, as well as cardiac arrest, which will become fatal as a result.
In case of an overdose of the drug, the patient needs medical supervision. Symptomatic and supportive treatment is required. It is possible to perform gastric lavage and artificially induce vomiting.
Drug interactions
When taking the antiparkinsonian drug levodopa simultaneously with the drug No-shpa in any of its release forms, tremor and rigidity may significantly increase.
The antispasmodic effect will be mutually enhanced when No-shpa is combined with other antispasmodics and m-choline blockers, among others.
When using No-shpa by injection together with the use of quinidine and tricyclic antidepressants, as well as procainamide, arterial hypotension may increase.
The spasmogenic activity of morphine will decrease when combined with No-shpa injections.
The effect of drotaverine will be enhanced when combined with phenobarbital.
Accurate data on the drug interaction of drotaverine with those drugs that can significantly bind to plasma proteins are not provided. Considering its wide abilities in this area, it can be assumed that their interaction will lead to the displacement of one by the other from the binding point and to an increase in the concentration in the blood plasma of one of the free fractions. Perhaps we can expect an increase in the effect of the drug that will eventually enter the bloodstream.
Additional instructions
For patients with hypersensitivity to sodium bisulfite, which is part of the drug solution, in order to avoid severe allergic reactions in the form of bronchospasm and anaphylactic shock You should stop taking No-shpa in the form of injections.
To prevent the development of collapse in patients with low blood pressure, intravenous administration of the drug should be carried out in a supine position.
Ingestion of therapeutic doses of the drug does not affect the ability to drive or perform work that requires increased concentration. However, if side effects of the drug manifest themselves, it is better to refrain from working.
The use of the drug by injection involves avoiding driving and potentially dangerous activities for some time.
No-shpa analogue
In pharmacies you can find an equivalent analogue of the drug No-shpa, which is more affordable, but is in no way inferior to it in providing an antispasmodic effect. The medicine is produced by a domestic manufacturer and is called Biospa.
No-shpa price
The cost of the drug, as a rule, depends on the manufacturer and may have different prices for equal packages of medication.
No-spa tablet price
The price of the drug in the form of tablets, depending on the number of pieces in the package, ranges from 176 to 259 rubles.
No-spa in ampoules price
The price of the drug in the form of a solution also depends on the number of ampoules in the package. So a pack of five ampoules of two milliliters can be purchased for 102 rubles. And the cost of a package with ampoules of the same volume, but in the amount of 25 pieces, will be 513 rubles.
No-spa has a pronounced antispasmodic effect on smooth muscles internal organs.
Used for spasms of the gastrointestinal tract, biliary tract, angina pectoris, urolithiasis, peripheral vessels. The active ingredient is drotaverine.
The effect of taking this medicine occurs within a few minutes. After half an hour, the phase of maximum effect from taking this antispasmodic begins.
Can be used orally (tablets) and pre-enterally (solution for injection).
Clinical and pharmacological group
Myotropic antispasmodic.
Conditions for dispensing from pharmacies
Dispensed without a doctor's prescription.
Prices
How much does No-shpa cost in pharmacies? The average price is 75 rubles.
Release form and composition
No-shpa tablets are small in size, round in color and yellow in color.
- Tablet composition: 40 mg drotaverine (in the form of hydrochloride), magnesium stearate, povidone, talc, corn starch, lactose (in the form of monohydrate).
- Forte tablets have an identical composition. The only difference is the higher concentration of the active substance (80 mg/tablet).
- Composition of No-Shpa in ampoules: drotaverine hydrochloride at a concentration of 20 mg/ml, 96% ethanol, sodium metabisulfite, water for injection.
No-shpa tablets are packaged in blister packs of 6 and 24 pieces, as well as in glass bottles of 60 and 100 pieces. A cardboard pack contains one blister or bottle with the appropriate number of tablets, as well as instructions for use of the drug.
Pharmacological effect
Main active component No-shpa is drotaverine hydrochloride, an antispasmodic that has a positive effect on the smooth muscles of the genitourinary and biliary tract, as well as the gastrointestinal tract. The substance helps effectively relieve swelling, normalizes blood circulation and eliminates inflammation in muscle tissue.
The main advantage is the absence negative impact drug components on functioning nervous system. After taking the tablets, the result is felt after 20 minutes, a greater effect is achieved after 1 hour. When the solution is administered intravenously, after 2-5 minutes, the maximum effect is after 30 minutes. Complete elimination of drotaverine from the body occurs 72 hours after administration.
Indications for use
What does it help with? No-spa can be used both as a primary and as an auxiliary therapeutic agent for a number of pathological conditions:
- Colic;
- Spasm of the arteries;
- Spastic constipation;
- Pielite;
- Tenesmach;
- Proctitis;
- Endarteritis;
- Spasm of cerebral vessels.
In addition, No-shpa is used for certain conditions to alleviate and relieve unpleasant symptoms.
No-Shpa for children
It is advisable to give the medicine to children for cystitis and nephrolithiasis, sudden spasms of the duodenum or stomach, gastritis, enteritis, colitis, flatulence, constipation, spasm of peripheral arteries, high fever and severe headaches.
40 mg tablets are prescribed to children from the age of six. Clinical studies of the safety and effectiveness of Forte tablets in children have not been conducted.
Contraindications
- Lactase deficiency, hereditary galactose intolerance, galactose-glucose malabsorption syndrome (tablets, due to the presence of lactose monohydrate in their composition);
- Age up to 6 years (tablets);
- Breastfeeding period (due to the lack of necessary clinical data confirming the safety and effectiveness of No-shpa for this group of patients);
- Severe heart failure (low cardiac output syndrome);
- Severe liver or kidney failure;
- Hypersensitivity to the components of the drug.
No-shpa should be used with caution against the background of arterial hypotension, in children and during pregnancy.
At intravenous administration injection solution due to the risk of collapse, the patient must lie down.
Use during pregnancy and lactation
During pregnancy, it is possible to use the drug No-shpa only in cases where the expected benefit is several times greater possible danger for the development and health of the fetus. In this case, the dosage is selected strictly individually.
Dosage and method of administration
The instructions for use indicate that when taking No-Spa without consulting a doctor, the recommended duration of taking the drug is usually 1-2 days. In cases where drotaverine is used as adjuvant therapy, the duration of treatment without consulting a doctor may be longer (2-3 days). If pain persists, the patient should consult a doctor.
The effectiveness of No-Shpa is three to four times higher than the effectiveness of Papaverine. In addition, the drug is characterized by 100% bioavailability. When taking a tablet, drotaverine is very quickly absorbed from the gastrointestinal tract: the half-absorption period of the substance is 12 minutes.
Dosages of No-shpa:
- Adults are prescribed 1-2 tablets. per dose 2-3 times/day. Maximum daily dose– 6 tab. (which corresponds to 240 mg).
- Clinical studies with the use of drotaverine have not been conducted in children. If the drug No-shpa is prescribed for children aged 6 to 12 years - 40 mg (1 tablet) 1-2 times a day, for children over 12 years old - 4 mg (1 tablet) 1- 4 times/day or 80 mg (2 tablets) 1-2 times/day. The maximum daily dose is 160 mg (4 tablets).
If the patient can easily independently diagnose the symptoms of his disease, because... They are well known to him, then the effectiveness of treatment, namely the disappearance of pain, is also easily assessed by the patient. If within a few hours after taking the drug at the maximum single dose there is a moderate decrease in pain or no decrease in pain, or if the pain does not decrease significantly after taking the maximum daily dose, it is recommended to consult a doctor.
When using a bottle with a polyethylene stopper equipped with a piece dispenser: before use, remove the protective strip from the top of the bottle and the sticker from the bottom of the bottle. Place the bottle in your palm so that the dispensing hole on the bottom does not rest against your palm. Then press on the top of the bottle, causing one tablet to fall out of the dispensing hole at the bottom.
Side effects
Side effects associated with the use of No-shpa occur quite rarely. The most common ones are:
- feeling of increased heart rate;
- nausea;
- itchy skin rash;
- feeling of restlessness;
- insomnia;
- decreased blood pressure;
- constipation;
- headache;
- Quincke's edema;
- dizziness.
Overdose
Significantly exceeding the recommended therapeutic dose of No-shpa tablets can lead to disturbances in the rhythm of heart contractions (arrhythmia), as well as to disruption of intracardiac conduction, up to complete blockade with cardiac arrest.
Treatment of overdose consists of gastric and intestinal lavage, taking intestinal sorbents ( Activated carbon), as well as carrying out symptomatic therapy in a medical hospital.
special instructions
The 40 mg tablets contain 52 mg of lactose monohydrate, which may result in complaints from digestive system in patients with lactose intolerance. This form is not intended for patients with lactase deficiency, galactosemia or impaired glucose/galactose absorption syndrome.
If any adverse reactions occur, the issue of driving and operating machinery requires individual consideration. If dizziness occurs after taking the drug, potential activities should be avoided. dangerous species activities such as management vehicles and working with machinery.
Drug interactions
PDE inhibitors like papaverine reduce the antiparkinsonian effect of levodopa. When No-shpa is prescribed simultaneously with levodopa, rigidity and tremor may increase.
With the simultaneous use of drotaverine with other antispasmodics, including m-anticholinergics, a mutual enhancement of the antispasmodic effect occurs.
No-spa is a well-known, time-tested medicine. Almost all home medicine cabinets contain this drug. Often parents are afraid to give this drug to young children. After all official instructions The instructions for use indicate that the medicine should not be given to children under 6 years of age. In what cases is No-shpa for children prescribed with more early age and how does it work?
No-spa is an antispasmodic that effectively affects muscle tissue human internal organs and blood vessels. The drug relieves muscle tone, while expanding the vessels through which blood circulates.
The main substance is drotaverine. It is he who has a pronounced antispasmodic effect. After taking the medication, blood circulation is normalized, all organs and tissues are additionally saturated with oxygen. Painful spasms in this case are significantly reduced or completely disappear.
The drug comes in the following types:
- Tablet form;
- Oval capsules;
- Ampoule with liquid substance.
After taking No-shpa tablets, the effect occurs within an hour in children. Intramuscular administration of the drug works much faster - after 20 minutes.
Important! No-shpa injection solution cannot be prescribed to persons under 18 years of age.
When can a doctor prescribe No-shpa for children?
Children under 6 years of age should be given medicine with great caution. It is important to know that drotaverine, which is the main active ingredient of the drug, is synthesized artificially. In other words, this substance is not a natural component. Therefore, treatment of symptoms in children with the drug No-shpa should only occur as prescribed by a doctor.
The drug is an excellent antispasmodic, but it does not have an analgesic effect like analgin and similar drugs. The medication has certain contraindications, which also need to be taken into account when treating children.
Usually the medicine is prescribed to young patients in the following cases:
- : heat with cold extremities. In this case, No-spa can relieve vasospasm, dilate blood vessels, improve blood circulation;
- Spasms during or stenosis causing severe coughing;
- Spasms causing headaches;
- Intestinal or renal colic;
- Excessive painful gas formation;
- Smooth muscle spasm during pyelitis;
- Spasms due to colitis or gastritis.
Important! No-spa has only a symptomatic effect, that is, it eliminates the spasm that caused the pain, but does not treat the cause of the spasm itself. Therefore, No-shpa is an adjunct that should be prescribed together with the main medicine.
Contraindications
Nosh-pa for treating small children should be used with caution, keeping in mind possible contraindications. The drug should not be given to children in the following cases:
- Children under 1 year of age;
- Low blood pressure in a child;
- Individual intolerance to drotaverine in children;
- Bronchial asthma;
- Vascular diseases (atherosclerosis);
- The baby is suspicious;
- Suspicion of appendicitis;
- Liver or kidney failure.
Important! In some cases, a doctor may prescribe a few drops of No-Shpa in ampoule form to an infant under 1 year of age for acute antispasmodic pain or white fever.
After taking the medicine, your child may experience some side effects:
- Indigestion. Some time after the child has taken the drug, he may experience nausea, often accompanied by vomiting. Stomach upset, constipation, and increased gas production are also possible.
- From the outside of cardio-vascular system Problems after taking the drug rarely occur. But if a child experiences tachycardia or a sharp drop in blood pressure, which is expressed in drowsiness and lethargy, then you should stop taking the drug.
- No-spa can cause dizziness and insomnia in a child. In such cases, it is also necessary to stop using the drug.
- Allergy. No-shpa rarely causes allergic reactions, however, sometimes the baby may experience sneezing and a rash on the body.
If side effects occur, it is recommended to stop taking the drug immediately.
Dosage of medicine for children
In pediatrics, the medicine is prescribed to children over one year of age. The use of the drug in children under 1 year of age may interfere with the functioning of the cardiovascular system. However, sometimes the medication is prescribed in small doses to newborns. The drug effectively relieves spasms and colic in infants. If the child is on breastfeeding, it is enough for the mother to take 1 tablet of No-shpa before feeding. The active substance enters the newborn's body through mother's milk in minimal quantities, relieving pain, spasms and colic. At artificial feeding The baby may be given a strictly defined dosage of medication as prescribed by the doctor, dissolved in boiled water.
The amount of the drug that needs to be given to the child depends on two factors: the form of release of the drug No-shpa and the age of the child.
- Children from 1 year to 6 years. Usually this age group the drug is prescribed with extreme caution, 1/3 tablet 3 to 6 times a day, depending on the severity of the condition. Taking No-shpa for children in this group should not exceed 2 tablets per day;
- Children from 6 to 12 years old. 1/2 tablet 3 to 8 times a day, depending on the severity of the condition. Taking No-shpa for children in this group should not exceed 4 tablets per day;
- Children over 12 years old. 1 tablet 3 to 5 times a day, depending on the severity of the condition. Taking No-shpa for children in this group should not exceed 5 tablets per day.
No-shpa is effective remedy, relieving various spasms. This drug should be used to treat children with extreme caution and only when absolutely necessary. Children over 6 years of age can be given the drug No-shpa without fear. However, you should remember that you can give your child medicine without a doctor’s prescription for no more than two days.
Remember that only a doctor can make a correct diagnosis; do not self-medicate without consultation and diagnosis by a qualified doctor.
Content
Spasm is one of the symptoms of a disease of the internal organs. Antispasmodics are used to relieve spasms. The annotation “No-spa - instructions for use” states that the drug contains substances whose action is aimed at relieving attacks of spastic (intermittent) pain, improving blood supply to tissues, dilating blood vessels. The drug under analysis lowers blood pressure and is available in the form of tablets and ampoules for injections.
No-shpa antispasmodic
The medication is the most popular antispasmodic drug, because compared to other drugs it has few contraindications and side effects. Therefore, it is often prescribed to children and pregnant women. Being a relaxing antispasmodic, No-Spa is four times more effective at affecting the cause of spasms than Papaverine. It has a vasodilating effect and increases blood flow to organs.
Composition and release form
The main component of No-shpa is a synthetic substance called drotaverine hydrochloride. The active component reduces the flow of calcium into smooth muscle cells, relieves tension in internal organs and blood vessels, and blocks nerve impulses without affecting the nervous system itself. The direct effect of the antispasmodic No-shpa on smooth muscles allows it to be used, with great caution, as an analgesic for adenoma prostate gland and angle-closure glaucoma. Below is the composition different forms release:
Mechanism of action
The mechanism of entry and rate of absorption into the bloodstream does not depend on the method of administration of the substance drotaverine. Drotaverine is rapidly absorbed both after oral administration (tablets) and after parenteral administration (injections). The mechanism of action of No-shpa is an antispasmodic effect achieved through intervention in the mechanism of muscle contraction. The maximum concentration of the substance in the blood serum is achieved within 45-60 minutes after oral administration. The drug has a high binding to plasma proteins, metabolism occurs in the liver (excretion into bile).
What does No-shpa help with?
The medication is prescribed when antispasmodic pain occurs to alleviate the condition of the patient with peptic ulcer stomach and duodenum. The use of the drug is effective even when the patient has an ulcer in the acute stage. The medication helps relieve spasms in proctitis, pancreatitis, colitis and pyelitis, and urolithiasis of the kidneys. The product is used for the following diseases and states:
- spasms of smooth muscles of internal organs (renal colic, biliary colic, intestinal colic, cholecystitis, dyskinesia biliary tract and gallbladder);
- pylorospasm, gastroduodenitis;
- bronchial asthma;
- cystitis;
- endarteritis, spasm of peripheral, cerebral, coronal arteries;
- algodismenorrhea, threatened miscarriage, threatened premature birth, spasm of the uterine pharynx during childbirth, prolonged opening of the pharynx, postpartum contractions;
- spasm of cerebral vessels;
- cholangitis;
- during pregnancy, to relieve cervical spasms (decreased tone) and weaken its contractions during childbirth;
- to relieve spasms of smooth muscles after surgical intervention;
- to carry out certain medical research.
For toothache
The drug No-shpa is ineffective for toothache. The drug may have a temporary analgesic effect, but it should not be used according to instructions and in an unusual way. No-shpa tablets need to be crushed into powder and applied to the diseased tooth, which will allow the drug to quickly penetrate the pulp cavity. The gums will become numb, the pain will subside, but an anesthetic effect is possible provided direct impact medications for nerve bundle tooth through a carious cavity (area of caries).
For migraine
But-spa cannot always eliminate headaches. Migraine – chronic illness nervous system. Migraine attacks are accompanied by severe headaches that arise as a result of dilation cerebral vessels, and not their spasms. The medication will not save you from migraine, because it does not eliminate vascular pain. But No-Shpa effectively fights fatigue and helps with insomnia if it is caused by squeezing sensations in the head.
No-spa for the stomach
Antispasmodics are mandatory drugs in the treatment of abdominal pain of mild to moderate intensity. Antispasmodic No-shpa is prescribed for drug therapy patients with symptoms of insufficient excretion digestive enzymes, patients with irritable bowel syndrome (mild), dyskinesia of the gallbladder, with exacerbation of peptic ulcers and cholelithiasis, with stool disorders, to relieve menstrual pain.
Directions for use and dosage
Depending on the purpose of use, the drug is used intravenously, intramuscularly, or orally. Intravenous injections medication carried out only under supervision medical worker, it is prohibited to do this at home. The annotation “No-spa - instructions for use” indicates the following dosage: adults up to 2 tablets per day or up to 4 ml intravenously.
Pills
Convex round tablets yellow color. There is an engraving on one side. The maximum daily dose for adults is 6 tablets or 240 mg. As drug therapy, patients are prescribed 2 tablets three times a day. The maximum daily dose for children is 4 tablets or 160 mg. You should consult your doctor regarding the duration of use. In normal cases, the course is 2 days.
No-shpa Forte
Antispasmodic myotropic action - No-shpa Forte is available in the form of tablets and solution for intramuscular and intravenous administration. Adults are prescribed 1 to 2 tablets per day 3 times or 2 to 4 ml 1-3 times. To relieve hepatic and renal colic the drug is administered intramuscularly in 2-4 ml doses. For peripheral vascular disease, the medication is administered intra-arterially.
No-spa in ampoules
To give a No-shpa injection, you need to fill a sterile syringe purchased at a pharmacy with medicine from the ampoule. No need to dilute with water. The injection solution is intended for intramuscular administration (dosage 40-240 mg). No-spa is injected intramuscularly slowly (30 seconds) deep into the muscle tissue. Before use, you can hold the ampoule in your hand to warm it to body temperature. No-spa is administered intravenously in rare cases at a dose of 40-80 mg under the supervision of a doctor.
special instructions
Cautious use is indicated for prostate adenoma, glaucoma, atherosclerosis coronary arteries. In the treatment of gastric and duodenal ulcers, the drug is used in combination with other antiulcer drugs. In tablet form, the medication is not prescribed to patients with impaired absorption of glucose into the blood, with lactose deficiency. After intravenous administration, you should not engage in work that requires high concentration for an hour. Alcohol reduces the effect of taking it, but the drug alleviates hangovers.
During pregnancy and breastfeeding
The main reason for prescribing No-shpa to pregnant women is the treatment of spasms of hollow organs, primarily the smooth muscles of the uterus. In most cases, a pregnant woman is prescribed 1-2 tablets three times a day. The effect of the drug begins after 30-40 minutes. To speed up the effect, you can put the tablet under your tongue and dissolve.
To speed up the process of dilation of the cervix during childbirth and reduce the risk of injury, 40 mg of the drug is first administered. If the effect is weak, you can repeat it.
Use during lactation: getting into breast milk, the active substance enters the baby's body. A single dose will not have any effect negative influence on the child's body. If the mother is prescribed a long course of taking No-shpa, she will have to stop breastfeeding. Some components of the drug may have undesirable toxic effects on the baby.
No-shpa for children
In the annotation to No-shpe - in the instructions for use it is written that clinical studies on the effect of drotaverine on children's body were not carried out. In pediatrics, it is possible to prescribe the drug No-shpa to a child if the following conditions: age after one year, no contraindications to the components of the drug, strict adherence to permissible medicinal dose determined by the doctor. No-spa is prescribed to children for the following diseases:
- cystitis;
- nephrolithiasis (kidney stones);
- spasms of the stomach and duodenum, gastritis, colitis, enteritis, constipation, flatulence;
- headache;
- heat;
- spasms of peripheral arterial vessels.
No-shpa for children under one year old
No-shpa is not prescribed to children under one year of age, but when intestinal colic For a baby, a nursing mother can take one tablet of medicine. Active substance(a small amount of it) will pass into the milk and have an antispasmodic effect on the child’s body. On the forums you can read advice on how to treat a child under one year old with No-shpa solution from an ampoule. But you should never self-medicate. Treatment and preventive recommendations are provided only by a pediatrician after medical examination.
Drug interactions
When used simultaneously with other medicines drotaverine can both enhance their effectiveness and weaken it. According to the instructions, drotaverine, when administered intravenously, enhances the effect of other antispasmodics: atropine, papaverine, bendazole. Together with tricyclic antidepressants, it helps to quickly reduce blood pressure. The drug increases the ability of phenobarbital to eliminate spasms and reduces the activity of morphine. The simultaneous use of drotaverine and Levodopa increases tremor.
Side effects
Clinical trials showed good tolerability of drotaverine by patients. However, complications may occur during drug treatment and adverse reactions. As indicated in the instructions, this is a feeling of heat, sweating, nausea, constipation, headache, dizziness, arrhythmia, palpitations, decreased blood pressure, dermatic manifestations. With long-term use of No-shpa laboratory parameters liver and kidney functions do not change. With intravenous administration of the drug No-shpa, the following are possible:
- decrease in blood pressure until the onset of clinical death;
- manifestations of arrhythmias;
- development of AV block;
- paralysis of the respiratory center.
Overdose
There were no cases of drug overdose when taking the recommended dose. The instructions indicate that when long-term treatment and exceeding the permissible dose of the drug, drotaverine suppresses the activity of the heart muscle, which can lead to cardiac arrest and respiratory paralysis. The patient should receive treatment under the supervision of a physician. Elimination of the consequences of an overdose includes washing the gastrointestinal tract area and inducing artificial vomiting.
Contraindications
According to the instructions, the drug should not be used if the body is hypersensitive to active substance or one of the auxiliary components. No-shpa is not prescribed to children under one year of age, or if the patient has severe forms liver, kidney, heart failure, arterial hypotension (lowering blood pressure), 2nd and 3rd degree AV block, with galactose intolerance.
Terms of sale and storage
You can purchase the drug in tablet form at the pharmacy without a doctor’s prescription, and the injection solution can be purchased only as prescribed by a doctor. According to the instructions, everything dosage forms No-shpa drug is stored in a dark, dry place, out of reach of children, at room temperature 15-25 degrees.
Analogues
Most cheap analogue analyzed antispasmodic – Drotaverine. According to the instructions, the medicine is identical in its mechanism of action and composition. The price of a substitute drug varies from 30 to 130 rubles. Analogs of the drug are made on the basis of papaverine or drotaverine. An unusual substitute is also sold - the Indian drug Spazoverine. A drug containing paracetamol and codeine, No-shpalgin, has a strong analgesic effect. Other analogues:
- Nosh-Bra;
- Drotaverine Forte;
- Papaverine;
- Spasmonet;
- Spasmol.
Price No-shpa
You can buy a prescription form of the antispasmodic with instructions through an online pharmacy. To do this, you order delivery of the medicine to a convenient point of delivery, and provide the prescription to the courier or show it to the parcel delivery manager. The price of the antispasmodic depends on the place of sale, the availability of a discount and the form of release. The cheapest modification of the medicine is tablets. Below is the cost of this antispasmodic in various online pharmacies:
Video
