The article tells how Sulfadimethoxine is used, what the medicine helps with, Sulfadimethoxine contraindications and side effects.

Medicine "Sulfadimethoxine": what it does

The drug "Sulfadimethoxine" is antibacterial drug with a wide spectrum of action.

Therapeutic effect of the drug "Sulfadimethoxine"

Whatever the drug is prescribed for, it really is effective medicine. The active component has an antibacterial effect against gram-positive bacteria - staphylococci, chlamydia and streptococci. The medicine also fights gram-negative microorganisms - Shigella, Klebsiella and other bacteria. Compared to other antibiotics, the drug has long term actions.

Medicine "Sulfadimethoxine": what is it used for?

The drug is prescribed for the treatment of infectious inflammatory diseases that are caused by microorganisms that are sensitive to active components drug. The following diseases can be treated with this product:

• wound infections,
• inflammation of the urinary and biliary tract,
• bronchitis,
• sinusitis,
• trachoma,
• erysipelas,
• dysentery,
• otitis,
• angina.

Release form

The drug is produced in the form of tablets containing active substance in amounts of 200, 500 mg. In addition, the medicine can be included as an active ingredient in Levosin ointment, which is used externally.

Analogues

Medicines that have a similar effect include Sulfapyridazine and Sulfalene tablets, as well as Sulfalene-meglumine injection solution.

Contraindications for the drug “Sulfadimethoxine”:

Do not use the medicine if:

• chronic heart failure,
• azotemia,
• renal and liver failure,
• porphyrias,
• inhibition of bone marrow hematopoiesis,
• glucose phosphate dehydrogenase deficiency,
• sensitivity to components,
• during pregnancy and lactation.

Side effects

The drug may cause such unwanted effects, How:

• agranulocytosis,
• dyspeptic skin rashes,
• leukopenia,
• cholestatic hepatitis,
• nausea,
• headache,
• drug fever,
• vomit.

How to use the drug "Sulfadimethoxine"

Drink plenty of fluids during therapy. Adults are prescribed one gram of the drug, children are given the medicine at the rate of 25 mg per kilogram of weight. This dose should be taken on the first day. In the next day, the volume of the product is halved. As a rule, the use of the drug is effective for a treatment duration of seven to ten days. Maintenance doses of the drug should be taken for at least three days after the temperature has returned to normal. At severe forms diseases in combination with drugs from the group of erythromycin, penicillin and some others.

Latin name: Sulfadimethoxinum
ATX code: J01ED01
Active substance: Sulfadimethoxine
Manufacturer: Darnitsa CJSC, Ukraine
Conditions for dispensing from a pharmacy: Over the counter

Composition of the drug

One tablet contains five hundred milligrams of sulfadimethoxine, calculated as one hundred percent dry matter. As additives to the active ingredient, the composition contains aerosil, gelatin, calcium stearate, and potato starch.

Medicinal properties

Sulfadimethoxine is an antibacterial drug with pronounced long acting. This antibiotic has proven its effectiveness against both gram-negative and gram-positive microorganisms, such as staphylococci, klebsiella, streptococci, salmonella, toxoplasma, shigella, malarial plasmodia, some chlamydia including Chlamydophila trachomatis, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae. Absorption of the active substance by the gastrointestinal tract occurs relatively slowly. The substance can be detected in the blood after thirty minutes. The maximum concentration is reached after eight to twelve hours. The therapeutic concentration required for an adult occurs when taking one or two grams of the substance on the first day, and half a gram or one gram on the following days. Bioavailability ranges from seventy to one hundred percent. The half-life of the antibiotic is forty hours. Excretion from the body is carried out mainly by the kidneys, partly with bile.

Indications for use

Sulfadimethoxine helps with uncomplicated inflammatory diseases biliary and urinary tract, dysentery. It is also used for trachoma, erysipelas, wound infection, otitis (more about purulent otitis read the article:), tonsillitis and sinusitis, bronchitis, pyoderma, gonorrhea, pneumonia, toxoplasmosis, malaria, cholecystitis, beshikha.

Release forms

Average price - 40 rubles

Sulfadimethoxine is a white or yellowish-cream tablet, odorless, round in shape, with a flat surface and a line on one side.

Mode of application

Sulfadimethoxine is taken every day, on the first day a dosage of one to two grams is usually prescribed, and on the following days from half a gram to one gram.

For children, this antibiotic is prescribed twenty-five milligrams on the first day and twelve and a half milligrams the next.

The duration of treatment is as long as prescribed by the attending physician, but usually the course of treatment with antibiotics lasts no more than ten days and is accompanied by the use of probiotics to restore the intestinal microflora.

During pregnancy and breastfeeding

Sulfadimethoxine crosses the placental barrier and is released into breast milk. For this reason, the antibiotic is not prescribed to pregnant and breastfeeding women.

Contraindications

The main contraindication to the use of Sulfadimethoxine is hypersensitivity to the components. You should not take the drug if you have severe dermatitis, hepatitis, drug fever, porphyria, or if you are breastfeeding or pregnant.

Precautionary measures

The medicine is prescribed with particular caution to those categories of patients who have impaired liver and kidney function, as well as to patients with chronic heart failure and diseases of the circulatory system.

Interaction with other drugs

The drug tends to reduce the effectiveness of bactericidal antibiotics that act exclusively on dividing microorganisms, such as cephalosporins and penicillins.

When sulfadimethoxine is combined with barbiturates, its activity increases, and with salicylates, the toxic effect of the drug increases, as well as when combined with methotrexate and diphenine. And when combined with streptomycin, monomycin, kanamycin, the antibacterial effect will not change. When sulfadimethoxine is combined with nalidixic acid, chloramphenicol, or nitrofurans, a decrease in the overall therapeutic effect may be observed.

Side effects

As side effects There are such as allergies in the form of urticaria, bronchospasms, hyperemia, swelling of the tongue and upper lip, Quincke's tumor, Lyell's and Stephen-Jones' syndromes. And also photodermatosis, anaphylactic shock and others. Nausea and vomiting, cholestatic hepatitis, dyspepsia, agranulocytosis, fever, headache and leukopenia, pancreatitis, dry mouth, diarrhea, jaundice, hepatic encephalopathy, syncope, aseptic meningitis, increased intracranial pressure, depression, optic neuropathy, psychosis, insomnia, myocarditis, fibrosing alveolitis, periarteritis nodosa, dark staining of urine yellow, tubular necrosis, hypothyroidism, hypoglycemia, thrombocytopenia, hemolytic anemia, hypothrombanemia.

Overdose

There is no information about cases of overdose.

Conditions and shelf life

The drug must be stored away from light sources, in a dark place. It is also recommended to hide the tablets out of the reach of children. The medicine can be stored for up to 5 years. It is not recommended to use the drug after this period has expired. The date of manufacture must be looked at on the packaging of the drug. If the storage conditions are not met, there is no effectiveness from taking it.

Analogues

NizhPharm, Russia
Price— 79 rubles

The composition includes: Dioxomethyltetrahydropyrimidine + Sulfadimethoxine + Trimecaine + Chloramphenicol, ointment in an aluminum tube.

Pros:

• Opportunity local application antibiotic directly on damaged necrotic tissue with minimal negative effects on the liver and intestines due to less absorption into the blood.
• Higher effectiveness on skin lesions when used local remedy in ointment form than in tablet form.
• To purchase of this medicine no doctor's prescription needed.

Minuses:

• Cons: For external use only.
• Due to the decrease in the effectiveness of the antibiotic after long-term use, it is not recommended to use it for more than the number of days prescribed by the therapist.

The drug Sulfadimethoxine belongs to pharmacological group antibacterial agents. It is available in the dosage form of tablets for oral administration and is used for the etiotropic treatment of infectious diseases caused by sensitive to active substance drug pathogens. The medicine is not used for children under 3 years of age, for pregnant and breastfeeding women, as well as for certain pathological conditions.

Dosage form

The drug Sulfadimethoxine is available in tablet form for oral use. They have a round shape, white or white with a yellow tint, a flat surface, as well as a groove and a chamfer. The tablets are packaged in blister packs of 10 pieces; a cardboard box contains 2 blisters and an annotation.

Description and composition

The main active compound of the drug is sulfadimethoxine, its content in 1 tablet is 250 or 500 mg. It also contains the following auxiliary compounds:

• Calcium stearate.
• Gelatin.
• Potato starch.
• Colloidal anhydrous silicon dioxide.

Pharmacological group

The main active component of the drug sulfadimethoxine is an antibacterial bacteriostatic agent wide range activity. It inhibits the growth and reproduction of bacteria, but does not kill them. The therapeutic effect is realized through competitive antagonism with para-aminobenzoic acid, which leads to suppression of the synthesis of tetrahydrofolic acid, necessary for the normal metabolism of purine bases (pyrimidines, purines are the structural basis of genetic material).

Sulfadimethoxine has a wide spectrum of activity. It stops growth and reproduction various types pathogenic (pathogenic) and opportunistic bacteria, which include staphylococci, streptococci, Friedlander's bacilli, shigella, chlamydia, and E. coli.

After taking the tablet, the active substance is relatively slowly absorbed into the systemic circulation. It penetrates poorly through histoplacental barriers. Metabolized in the liver, excreted from the body in the form of inactive breakdown products, mainly in the urine.

Indications for use

The main medical indication for the use of the drug Sulfadimethoxine is an infectious and inflammatory pathology caused by bacteria sensitive to the active component of the drug.

for adults

For adults, the drug is used for the following infectious diseases:

• Acute respiratory bacterial pathology.
• Bronchitis of bacterial origin.
• Pyoderma (purulent skin infection).
• Infectious pathology of the gallbladder and biliary tract.
• Wound infection.
• Erysipelas (specific infectious process in the skin caused by streptococci).
• Bacterial (inflammation of the membranes of the brain and spinal cord).
• Infectious ENT pathology (sinusitis, sinusitis).
• Urinary tract diseases.

The drug is also used for complex therapy malaria in combination with other antiprotozoal drugs.

for children

The drug Sulfadimethoxine can be used for children over 3 years of age for the same medical reasons as for adults.

The use of the drug for pregnant and breastfeeding women is contraindicated, since the active ingredient has Negative influence on the body of a developing fetus or infant.

Contraindications

Sulfadimethoxine tablets are contraindicated for use in certain pathological or physiological conditions of the human body, which include:

• Individual intolerance to any of the components of the drug.
• A history of allergic reactions to any sulfonamide drugs.
• Severe insufficiency of functional activity of the kidneys or liver.
• Deficiency of the enzyme glucose-6-phosphate dehydrogenase.
• Hemolytic anemia associated with excessive destruction of red blood cells.
• Chronic heart failure in the stage of decompensation.
• Increased concentration of nitrogenous compounds in the blood (azotemia).
• Inhibition of the process of hematopoiesis in the red bone marrow.
• Availability of certain metabolic disorders, which include porphyria.
• Severe dermatitis.

Applications and dosages

Sulfadimethoxine tablets are intended for oral administration once a day, the interval between doses should be 24 hours. Do not chew them and wash them down with plenty of water.

for adults

On the first day of treatment, adults are prescribed 2-4 tablets of Sulfadimethoxine (1-2 g). Then in the following days they switch to a maintenance dosage, which is 1-2 tablets per day (0.5-1 g). Average duration therapy lasts from 7 to 14 days, depending on the severity and location of the infectious process.

for children

Dosage for children depends on the age of the child:

• From 3 to 12 years – the dosage is calculated based on 25 mg of active substance per 1 kg of child’s body weight on the first day. Then in the following days it is reduced to 12.5 mg per 1 kg of the child’s body weight once a day.
• Over 12 years of age - on the first day of illness, 1 g (2 tablets) of sulfadimethoxine is prescribed. Then the next day they switch to a maintenance dosage, which is 0.5 g (1 tablet) 1 time per day.

for pregnant women and during lactation

Sulfadimethoxine tablets are contraindicated for pregnant and breastfeeding women.

Side effects

During the use of the drug, it is possible to develop negative reactions from various organs and systems:

• Gastrointestinal tract - thirst, dry mouth, nausea, periodic bloating, stool disorders, pseudomembranous colitis.
• Hepatobiliary system - increased activity of liver transaminase enzymes (AST, ALT), liver enlargement, death of organ tissue (hepatonecrosis), jaundice.
• Nervous system– aseptic and other neurological reactions, headache, increased intracranial pressure, gait disturbance (ataxia), disturbances of consciousness, convulsions skeletal muscles, insomnia or drowsiness, depression, increased fatigue, psychosis.
• Respiratory system – alveolitis, pulmonary infiltrates.
• Urinary system - the appearance of crystals in the urine, a change in its color (rich yellow), interstitial nephritis, tubular necrosis, insufficiency of functional activity of the kidneys.
• Blood – decrease in the number of platelets (thrombocytopenia), leukocytes (leukopenia), absence of granulocytes (agranulocytosis), development of aplastic or hemolytic anemia.
• Skin and subcutaneous tissue– photosensitivity, erythema nodosum, dermatitis.
• Allergic reactions– necrotizing epidermiolysis, skin rash, itching, Quincke's edema, anaphylactic reactions.
• General reactions of the body are increased body temperature, pain in the lumbar region.

Interaction with other drugs

When combined with drugs of certain groups, the therapeutic effects of the drug change:

• , dipheninone – increased toxic effect.
• Non-steroidal anti-inflammatory drugs, antithrombotic drugs - enhanced effects.
• Decreased activity bactericidal drugs, contraceptives.
• Barbiturates, PAS – enhancement of therapeutic effects.

special instructions

Before prescribing the drug, you should pay attention to several special instructions:

• During a long course of therapy, the condition of the blood, liver, and kidneys is periodically monitored.
• It is important to correctly determine the duration of therapy to prevent the emergence of resistant forms of bacteria.
• To prevent the formation of insoluble crystals in the kidneys during the course of therapy, it is important to drink enough water.
• It is recommended to avoid direct exposure sun rays on the skin.

Overdose

If the dose is significantly exceeded, dry mouth, pain in the right hypochondrium, nausea, abdominal pain appear, and the color of urine changes. Treatment of overdose is symptomatic.

Storage conditions

Storage in a dark, dry, inaccessible place at an air temperature no higher than +25° C. Shelf life - 5 years.

Analogues

There are no structural analogues for Sulfadimethoxine tablets. By therapeutic effect The following substitutes are distinguished:

• – antibacterial agent in tablets, can be used for adults and children from 3 months for various infectious diseases. Contraindications are pregnancy, lactation, renal, liver, and heart failure.
• – tablets, the active substance of which is a derivative of 5-aminosalicylic acid, it has an antimicrobial and anti-inflammatory effect. The drug is used for adults and children over 5 years of age. For strict medical reasons, it can be prescribed to pregnant women.

Price

The cost of Sulfadimethoxine is on average 973 rubles. Prices range from 20 to 3150 rubles.

Published on this page detailed instructions by application Sulfadimethoxine. Available dosage forms drug (tablets 200 mg and 500 mg), as well as its analogues. Information is provided on the side effects that Sulfadimethoxine can cause and on interactions with other medications. In addition to information about the diseases for the treatment and prevention of which the drug is prescribed (tonsillitis, otitis media, sinusitis and other infectious diseases), administration algorithms, possible dosages for adults and children are described in detail, and the possibility of use during pregnancy and breastfeeding is clarified. The abstract for Sulfadimethoxine is supplemented with reviews from patients and doctors. Composition of the drug.

Instructions for use and dosage

Adults on the 1st day of treatment - 1 g, on subsequent days - 500 mg per day. In severe cases of the disease, the dose may be increased. Children on the 1st day of treatment - 25 mg/kg, on subsequent days - 12.5 mg/kg per day.

Take orally 1 time per day after meals. The duration of treatment is 7-10 days.

Compound

Sulfadimethoxine + excipients.

Release forms

Tablets 200 mg and 500 mg.

Sulfadimethoxine- antibacterial agent, sulfanilamide derivative. Has a long-lasting effect when taken orally. The mechanism of action is associated with competitive antagonism with PABA and competitive inhibition of dihydropteroate synthetase, which leads to disruption of the synthesis of tetrahydrofolic acid, necessary for the synthesis of purines and pyrimidines.

Active against gram-positive bacteria: Staphylococcus spp. (staphylococcus), Streptococcus spp. (including Streptococcus pneumoniae) (streptococcus); gram-negative bacteria: Klebsiella pneumoniae, Escherichia coli ( coli), Shigella spp. (shigella).

Active against Chlamydia trachomatis (chlamydia).

Pharmacokinetics

After oral administration, it is detected in the blood within 30 minutes. It penetrates the blood-brain barrier (BBB) ​​poorly. Therapeutic concentration in adults is observed when taking 1-2 g on the first day and 0.5-1 g on subsequent days. Unlike other sulfonamides, primary metabolism occurs via the microsomal glucuronidation pathway associated with CYP450 and NADPH-dependent isoenzymes.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to sulfadimethoxine:

• angina;
• sinusitis;
• otitis;
• bronchitis;
• dysentery;
• inflammatory diseases of the biliary and urinary tract;
• erysipelas;
• wound infections;
• trachoma.

Contraindications

• hypersensitivity to sulfonamides;
• inhibition of bone marrow hematopoiesis;
• renal and/or liver failure;
• chronic heart failure;
• congenital deficiency of glucose-6-phosphate dehydrogenase;
• porphyria;
• azotemia;
• pregnancy.

special instructions

It is used externally as part of combination preparations.

Side effect

• headache;
• dyspeptic symptoms;
• nausea, vomiting;
• cholestatic hepatitis;
• skin rashes;
• drug fever;
• leukopenia, agranulocytosis.

Drug interactions

Sulfadimethoxine reduces the effectiveness of bactericidal antibiotics that act only on dividing microorganisms (including penicillins, cephalosporins).

Analogues of the drug Sulfadimethoxine

The drug Sulfadimethoxine has no structural analogues for the active substance.

Analogs by pharmacological group (sulfonamides):

• Arghedine;
• Argosulfan;
• Bactrim;
• Bactrim forte;
• Berlocid;
• Biseptol;
• Brifeseptol;
• Groseptol;
• Dapsone Fatol;
• Dvaseptol;
• Dermazin;
• Duo Septol;
• Inhalipt;
• Co-trimoxazole;
• Kotrifarm;
• Lidaprim;
• Metosulfabol;
• Oriprim;
• Polseptol;
• Septrin;
• Sinersul;
• Streptonitol;
• Streptocide;
• Streptocide soluble;
• Streptocide ointment 10%;
• Sulotrim;
• Sulgin;
• Sulfadimezin;
• Sulfalene;
• Sulfamethoxazole;
• Sulfanilamide;
• Sulfargin;
• Sulfasalazine;
• Sulfacetamide;
• Sulfacyl sodium (Albucid);
• Sumetrolim;
• Trimezol;
• Phthalazol;
• Phthalylsulfathiazole;
• Tsiplin;
• Etazol.

Use during pregnancy and breastfeeding

Attention! The information is provided for informational purposes only. This instruction should not be used as a guide to self-medication. The need for prescription, methods and doses of the drug are determined exclusively by the attending physician.

general characteristics

international and chemical names: sulfadimethoxine; 4-amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide;

basic physical and chemical properties: tablets white or white with a creamy tint, flat-cylindrical in shape, with a chamfer and a score;

compound: 1 tablet contains sulfadimethoxine 0.5 g;

Excipients: sodium starch glycolate, pregelatinized starch, calcium stearate.

Release form. Pills.

Pharmacotherapeutic group

Antimicrobial agents for systemic use. Sulfonamides (Sulfonamides- group of antimicrobials medicines, derivatives of sulfanilic acid. Used in the treatment of mainly infectious diseases) long-acting. ATC code J01E D01.

Pharmacological properties

Broad-spectrum antibacterial agent with bacteriostatic (Bacteriostatic- the effect of antibiotics, causing inhibition of the processes of reproduction of bacterial cells) effect.

Pharmacodynamics. Sulfadimethoxine, being a chemical structure analogue of para-aminobenzoic acid, interferes with its absorption and disrupts biosynthetic processes in cells bacteria (Bacteria- a group of microscopic, predominantly unicellular organisms. Many bacteria are causative agents of diseases in animals and humans. There are also bacteria necessary for normal life processes). Inhibits the growth and reproduction of gram-positive and gram-negative bacteria, including anaerobes (Anaerobes(anaerobic organisms) - some types of bacteria, yeast, protozoa that can live in the absence of atmospheric oxygen. Widely distributed in soil, water, bottom sediments) . Active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp. (including Streptococcus pneumoniae); gram-negative bacteria: Klebsiella pneumoniae, Escherichia coli, Shigella spp. Active against Chlamydia trachomatis.
The antimicrobial effect of sulfadimethoxine is significantly weakened in the presence of pus and tissue breakdown products.

Pharmacokinetics. When taken orally, it is absorbed relatively slowly from gastrointestinal tract; detected in the blood after 30 minutes. The maximum concentration in the blood is reached after 8–12 hours. The required therapeutic concentration in the blood (in adults) when taking 1–2 g is noted on the first day; maintenance doses (0.5–1 g) provide a therapeutic level in the blood throughout the course of treatment .
Penetrates well into body tissues and fluids, including pleural effusion, peritoneal and synovial fluid, exudate of the middle ear (Ear- organ of hearing and balance. Consists of the outer and middle ear, which conduct sound, and inner ear, perceiving it. Sound waves, captured auricle, cause vibration eardrum and then through the system auditory ossicles, liquids and other formations are transmitted to the receiving receptor cells), chamber moisture, tissue of the genitourinary tract. Penetrates through placenta (Placenta- an organ that carries out communication and metabolism between the mother’s body and the fetus during intrauterine development. Also performs hormonal and protective function. After the birth of the fetus, the placenta, along with the membranes and umbilical cord, is released from the uterus) and into breast milk. Penetrates poorly blood-brain barrier (Blood-brain barrier- a barrier formed by the endothelium of brain vessels: between endothelial cells there are no intercellular spaces characteristic of other vessels. As a result, water-soluble polar substances do not penetrate into the brain from the blood).
Metabolism (Metabolism- the totality of all types of transformations of substances and energy in the body, ensuring its development, life activity and self-reproduction, as well as its connection with environment and adaptation to changes external conditions) carried out primarily in the liver by microsomal glucuronidation. It is excreted in the form of metabolites, mainly by the kidneys, as well as with bile.

Indications for use

Infectious and inflammatory diseases caused by those sensitive to sulfadimethoxine microorganisms (Microorganisms- the smallest, mostly single-celled organisms, visible only under a microscope: bacteria, microscopic fungi, protozoa, sometimes viruses are included among them): respiratory tract and ENT organs (tonsillitis, bronchitis, pneumonia, otitis (Otitis- ear infection), sinusitis (Sinusitis- inflammation of the mucous membrane, sometimes of the bone walls maxillary sinus often occurs as a complication of influenza)), biliary and urinary tract, meningitis, shigellosis, wound infection, pyoderma (Pyoderma– these are skin diseases, the main symptom of which is suppuration), gonorrhea (Gonorrhea- a venereal disease caused by gonococcus. 3-5 days after infection, pain and suppuration appear from urethra. Inflammatory complications of the genital organs are possible, Bladder, joints, etc.), trachoma, erysipelas, toxoplasmosis; resistant forms malaria (Malaria– group of acute protozoans vector-borne diseases humans and animals, the pathogens of which are transmitted by mosquitoes of the genus Anopheles. Accompanied by fever, chills, splenomegaly (increase in the size of the spleen), hepatomegaly (increase in the size of the liver), anemia)(in combination with antimalarial drugs).

Directions for use and doses

Prescribed orally after meals, 1 time per day with an interval of 24 hours between doses.
Adults are prescribed:
for infections mild degree- on the first day 1 g (2 tablets), on subsequent days - by
0.5 g (1 tablet);
for moderate and severe infections - on the first day, 2 g (4 tablets), on subsequent days - 1 g (2 tablets). If necessary, the dose can be increased.
Children under 12 years of age are prescribed: on the first day, 25 mg/kg, on subsequent days – 12.5 mg/kg; children over 12 years old - 1 g (2 tablets) on the 1st day, 0.5 g on subsequent days
(1 tablet).
The duration of treatment depends on the severity of the disease and is 7–10 days.
Treatment must be continued for 2–3 days after body temperature normalizes.

Side effect

From the outside nervous system (Nervous system- a set of formations: receptors, nerves, ganglia, brain. Performs the perception of stimuli acting on the body, conducts and processes the resulting excitation, and forms adaptive responses. Regulates and coordinates all functions of the body in its interaction with external environment) : headache. From the outside digestive system: dyspepsia (Dyspepsia– digestive disorder resulting from a lack of enzymes or as a result of poor nutrition), nausea, vomiting, cholestatic hepatitis. Allergic reactions: skin rash, medicinal fever (Fever– a special reaction of the body that accompanies many diseases and is manifested by an increase in body temperature. A febrile reaction most often occurs with infectious diseases, with the introduction of medicinal serums and vaccines, with traumatic injuries, crushed tissue, etc.). From the hematopoietic system: rarely - leukopenia (Leukopenia- the content of leukocytes in the peripheral blood is less than 4000 in 1 μl, due to the influence of various damaging factors on the body), agranulocytosis.

Contraindications

Hypersensitivity to sulfonamides and other components of the drug, inhibition of bone marrow hematopoiesis, renal and/or liver failure, congenital deficiency of glucose-6-phosphate dehydrogenase, porphyria, azotemia, pregnancy, lactation, childhood up to 2 months.

Overdose

Possible worsening side effects. Treatment is symptomatic.

Features of application

The drug is contraindicated during pregnancy. Treatment should be stopped during treatment breast-feeding, since the drug passes into breast milk and can cause nuclear cancer in children jaundice (Jaundice- a painful condition characterized by the accumulation of bilirubin in the blood and its deposition in tissues with a yellow coloration of the skin, mucous membranes, and sclera of the eyes. Observed with increased breakdown of red blood cells (eg, neonatal jaundice, jaundice due to hemolytic anemia), viral hepatitis and other liver diseases, obstruction of bile outflow), and hemolytic anemia (Hemolytic anemia– anemia caused by increased hemolysis (destruction of red blood cells), which occurs due to a defect in the structure of red blood cell membranes) in children with glucose-6-phosphate dehydrogenase deficiency.
The use of the drug in children under 2 months of age is possible only for the treatment of congenital toxoplasmosis for health reasons.
Limitation to medical use the drug is chronic (Chronic- a long, continuous, protracted process, occurring either constantly or with periodic improvements in the condition) heart failure.
Prescribing the drug to patients over 65 years of age should be avoided due to increased risk development of severe side effects.
During a course of treatment, it is necessary to systematically monitor the state of renal function and peripheral blood patterns.
During therapy (Therapy- 1. The field of medicine that studies internal illnesses, one of the oldest and main medical specialties. 2. Part of a word or phrase used to indicate the type of treatment (oxygen therapy\; hemotherapy - treatment with blood products)) It is recommended to drink large amounts of alkaline drink, sufficient to maintain diuresis (Diuresis- the amount of urine excreted over a certain time. In humans, daily diuresis averages 1200-1600 ml) at a level of at least 1.2 l/day for adults.
During treatment with the drug, you must follow the dosage regimen, take the prescribed dose every 24 hours, and do not skip doses. If you miss a dose, take it as soon as possible; do not take if it is almost time for the next dose; do not double the dose. It is recommended to avoid exposure to direct sunlight and ultraviolet radiation.
Data on the effect of the drug on driving ability Vehicle and for execution potentially dangerous species There are no activities.

Interaction with other drugs

Reduces the effectiveness of bactericidal antibiotics (Antibiotics- substances that have the ability to kill microbes (or prevent their growth). Used as medications, suppress bacteria, microscopic fungi, some viruses and protozoa, there are also antitumor antibiotics), acting only on dividing microorganisms (including penicillins, cephalosporins). Antibacterial activity is reduced by procaine, benzocaine and tetracaine, and enhanced by barbiturates and para-aminosalicylic acid. Methotrexate and phenytoin increase toxicity (Toxicity- the ability of some chemical compounds and substances of biological nature have a harmful effect on the human body, animals and plants) sulfadimethoxine; non-steroidal anti-inflammatory drugs, thioacetazone, chloramphenicol, myelotoxic drugs enhance toxic (Toxic- poisonous, harmful to the body) effect on the blood. Sulfadimethoxine enhances the effect anticoagulants (Anticoagulants - medicinal substances, reducing blood clotting) indirect action, phenytoin, sulfonamides with hypoglycemic action; reduces efficiency oral (Orally- route of administration of the drug through the mouth (per os)) contraceptives. Pyrazolone derivatives, indomethacin and salicylates increase the free fraction of sulfadimethoxine in the blood.

General Product Information

Conditions and shelf life. Store in a place protected from light at temperatures from 8°C to 25°C. Keep out of the reach of children.
Shelf life – 5 years.

Vacation conditions. On prescription.

Package. 10 tablets in a blister pack and in a pack; 10 tablets in a blister pack.

Manufacturer.OOO " Pharmaceutical company"Health".

Location. 61013, Ukraine, Kharkov, st. Shevchenko, 22.

Website. www.zt.com.ua

Preparations with similar active ingredients

• Sulfadimethoxine - "Darnitsa"

This material is presented in free form on the basis of the official instructions for medical use of the drug.