"...I really love and respect chemistry.
It was thanks to my chemical brains (thanks to the university that there were no horror films like “2 in 1 physical colloid chemistry”) that I came to understand the absolute harm of vaccines, the dangers of using hormones and ABs. And we, chemists, or rather chemists related to bioorganic and other chemistry with the prefix bio-, have the expression “Doctors don’t know chemistry!” (your example about mercury methylation is clear evidence of this). I remember that one chemical name of the drug “Curantil” (prescribed during pregnancy) was enough for me to forever give up even the thought of using it. From his formula it clearly followed (for me) “terrible rubbish with a possible terratogenic effect (not obvious, so to speak, but long delayed).” Or a nephrologist prescribes for years six-month-old child furagin in a therapeutic dose for daily use (I understand at the molecular level that the doctor is beating the child - but this is absolutely incomprehensible to the doctor himself). The difference between the enteral and parenteral routes of drug intake was explained to us in detail at the cellular and molecular level. So, IMHO, having chemistry well laid out in the head of an allopathic doctor can even be very useful. Because they deal precisely with this immense chemistry in the form of tablets and ampoules. Yes, but on the other hand, the more you learn and understand about the effects of drugs, the less you want to use them. So, chemistry is either or medical practice- the main thing is that your head works well.
No comments. If your mother’s brains don’t snap back when reading this, I’m sorry... Yes, I like the different annotations for the drug best of all. Compare for yourself.
Chimes
Manufacturer: Berlin-Chemie AG, Germany
Release form: tablets 25 mg, 75 mg N100
Composition: 1 tablet contains dipyridamole 25 mg, 75 mg, 100 tablets per pack.
Action: Therapeutic cardiac agent.
Indications: Chronic cardiac weakness, especially with pain associated with disease of the coronary vessels of the heart (angina), for the prevention and subsequent treatment of myocardial infarction, with overload due to increased blood pressure, as a concomitant medication to prevent the formation of blood clots (thrombi), and the complications caused by this.
Contraindications: This drug is not allowed to be used in cases of fresh myocardial infarction, decompensated cardiac weakness, in severe forms of drop in blood pressure and related collapse states, in cases of heart rate, severe renal dysfunction, with a predisposition to bleeding and with increased sensitivity to dipyridamole. Pregnancy.
Directions for use: The dose is determined depending on the severity of the disease. In the absence of other prescriptions, in milder cases, take 1-2 drops of chimes 25-3 times a day. In more severe cases, the course of treatment usually begins with taking 3 tablets of Curantil 25, 3 tablets per day. At a higher concentration (75 mg of dipyridamole per 1 tablet, which corresponds to the content active substance 3 drops of chimes 25). Should be taken on an empty stomach, one hour before meals. without chewing and with a small amount of liquid.
Interaction: So-called xanthine derivatives (for example, caffeine) weaken or remove the effect of chimes on the heart. In this regard, it is not allowed to prescribe similar drugs at the same time. During treatment with chimes, you should also avoid drinking natural coffee or black tea.
Side effects: Heaviness in the head, headaches (in most cases, transient), gastrointestinal disorders, nausea, dizziness, feeling dazed, weakness, feeling of pressure and heat, drop in blood pressure ( shock possible). Sometimes there were cases of a temporary increase in heart rate (accelerated pulse), flushing, and occasionally allergic reactions on the skin. Higher dosages may cause changes in the conduction system of the heart.
How do you like your vitamin?
Now ANOTHER annotation for the same drug. From here http://apteka.mos.ru/new/medicine_k.jsp?idt=15211
Contraindications
Increased sensitivity acute heart attack myocardium, severe atherosclerotic lesions of the coronary vessels with a developed collateral system, predisposition to hypotension, severe intraventricular conduction disturbances, severe arterial hypertension, severe liver dysfunction, hemorrhagic diathesis, obstructive pulmonary diseases, II and III trimesters of pregnancy, children's and adolescence(up to 12 years old).
Side effect
Nausea, abdominal discomfort, facial flushing, coronary steal syndrome (exacerbation coronary disease heart), headaches, dizziness, bleeding, hypotension, thrombocytopenia, changes in the functional properties of platelets, tachycardia, bradycardia, weakness, rash.
And now, before we forget anything, look here again http://medi.ru/doc/161001.htm#gyn to our obstetricians-gynecologists
Materials of the 2nd Congress of the International Association of Pathologists M. - 1999, - p. 447
Three “critical” periods when increased therapy is necessary: 4-14 weeks, 20-24 weeks, 30-36 weeks!
Immunological aspects of reproductive Health, M. - 1995, p. 109-1271
Rationale for wide application Chimes for the treatment and prevention of miscarriage:
Safe at all stages of pregnancy*
Highly effective in stopping rheological disturbances in the placenta and systemic circulation*
The only drug that has a beneficial effect on the development of the placenta:
stimulates the growth of new vessels in the villous stroma*
promotes an increase in erythropoiesis in the wall of the yolk sac and liver of the embryo*
Reduces antibody aggression*
Boosts immunity*
* "Bulletin" Russian Association obstetricians-gynecologists" N4, 2000
Contraindications: Hypersensitivity, acute myocardial infarction, unstable angina, stenosing atherosclerosis coronary arteries, decompensated heart failure, subaortic aortic stenosis, hypotension and hypertension ( severe forms), collapse, arrhythmia, gastric ulcer and duodenum(in the acute stage), hepatic and/or renal failure, hemorrhagic diathesis, age up to 12 years.
Use during pregnancy and breastfeeding: Possible under medical supervision and according to indications.
Side effects: Nausea, vomiting, diarrhea, dizziness, headache, myalgia; hypotension, transient facial hyperemia, tachycardia; skin allergic reactions.
THE LAW THAT THE DRINKHOLE TURNED WHERE IT TURNED WHERE IT WENT OUT
IN Lately many pregnant women visiting antenatal clinics, report that they are prescribed a drug called “Curantil”. Moreover, this is often accompanied by outright intimidation. bad consequences for mother and child in case of refusal to accept this medicine. We decided to take a closer look at this “new fad” (by the way, you can do this yourself by looking at the pharmaceutical reference book) and discovered some very alarming facts:
So, chimes. The active ingredient in it is dipyridamole.
pharmachologic effect:
antiplatelet agent (thin the blood), has a vasodilating effect, immunomodulator (Stimulates an increase in the production of interferon, which can enhance autoimmune processes in the body. A practical example: taking chimes against the background of a common cold led to the development of severe autoimmune disease - bronchial asthma). Dipyridamole accumulates in the heart and red blood cells (blood cells).
Side effect:
From the outside digestive system- nausea, vomiting, diarrhea. From the outside of cardio-vascular system- decreased blood pressure, tachycardia (increased heart rate). From the side of the central nervous system - dizziness, headache. Possible allergic reactions - skin rash, urticaria. Others - myalgia (muscle pain), in some cases - increased bleeding.
Some contraindications:
heart failure, low blood pressure, hemorrhagic diathesis, conditions with increased risk development of bleeding, increased sensitivity to the components of the drug.
It is especially noted that this medicine is not recommended for children under 12 years of age. Is it possible for a fetus in the womb?
Well, we have already made some conclusions about the “safety” of chimes. And now something about the “effectiveness” of the drug. It is prescribed to pregnant women supposedly to improve uteroplacental circulation. However, the drug has a so-called “stealing” effect, that is, where blood circulation is already good, it improves, and where blood circulation is poor, it becomes even worse. Thus, in cardiology, dipyridamole is used for provocative tests to establish a diagnosis of coronary heart disease and angina. In such patients, outside of an attack, the electrocardiogram is normal, but the administration of dipyridamole provokes an attack, this is visible on the ECG, and thus it is diagnosed accurate diagnosis.
The article uses materials from the Vidal pharmaceutical reference book for 2006 and information provided by Dr. Alexander Alifanov
From No. 4/07
There are contraindications. Before starting use, consult your doctor.
Commercial names abroad (abroad) - Atrombin, Cardiwell, Persantine, Procardin, Thrombonil.
Currently, analogues (generics) of the drug are NOT FOR SALE in Moscow pharmacies!
Other drugs for the prevention and treatment of thrombosis.
You can ask a question or leave a review about the medicine (please, do not forget to indicate the name of the drug in the text of the message).
Curantil and Curantil N are NOT DIFFERENT in composition and method of application!
| Preparations containing only Dipyridamole (ATC code B01AC07) | |||||
|---|---|---|---|---|---|
| Name | Release form | Packaging, pcs. | Manufacturer country | Price in Moscow, r | Offers in Moscow |
| Curantyl | tablets 25mg | 100 | Germany, Berlin Hemi | 386- (average 529↗) -804 | 221↘ |
| Curantyl N25 (Curantyl N25) | tablets 25mg | 120 | Germany, Berlin Hemi | 386- (average 558↗) -854 | 231↘ |
| Curantyl N75 (Curantyl N75) | tablets 75mg | 40 | Germany, Berlin Hemi | 438- (average 587↗) -943 | 578↘ |
| Combination preparations containing dipyridamole | |||||
| Aggrenox | Capsules (dipyridamole 200 mg + acetylsalicylic acid 25 mg) | 30 | Germany, Boehringer Ingelheim | 785- (average 924↗) -1196 | 147↘ |
Curantil (Dipyridamole) - official instructions for use. The drug is a prescription, the information is intended only for healthcare professionals!
Clinical and pharmacological group:
Antiplatelet agent. Immunomodulator
pharmachologic effect
Vasodilator with myotropic action. It has an inhibitory effect on platelet aggregation and improves microcirculation.
Dipyridamole dilates arterioles in the coronary blood flow system, and when taken in high doses, in other parts of the circulatory system. However, unlike organic nitrates and calcium antagonists, dilation of larger coronary vessels does not occur.
The vasodilatory effect of dipyridamole is due to two different mechanisms of inhibition: inhibition of adenosine uptake and inhibition of phosphodiesterase.
In vivo, adenosine is found at concentrations of approximately 0.15-0.20 µM. This level is maintained due to the dynamic balance between ejection and reuptake. Dipyridamole inhibits the uptake of adenosine by endothelial cells, erythrocytes and platelets. After the administration of dipyridamole, an increase in the concentration of adenosine in the blood and an increase in adenosine-induced vasodilation are detected. At higher doses, platelet aggregation caused by adenosine is inhibited, and the tendency to thrombus formation decreases.
The breakdown of cAMP and cGMP, which suppress platelet aggregation, occurs in platelets under the action of corresponding phosphodiesterases. At high concentrations, dipyridamole inhibits both phosphodiesterases; at therapeutic concentrations in the blood, it inhibits only cGMP phosphodiesterase. As a result of stimulation of the corresponding cyclases, the power of cAMP synthesis increases.
As a pyrimidine derivative, dipyridamole is an interferon inducer and has a modulating effect on the functional activity of the interferon system, increases the reduced production of interferon alpha and gamma by blood leukocytes in vitro. The drug increases nonspecific resistance to viral infections.
Pharmacokinetics
Suction and distribution
After a single oral dose of 150 mg, the Cmax of dipyridamole in plasma averages 2.66 mcg/l and is achieved within 1 hour after administration.
Dipyridamole is almost completely bound to plasma proteins. Dipyridamole accumulates in the heart and red blood cells.
Metabolism and excretion
Dipyridamole is metabolized in the liver by binding to glucuronic acid. T1/2 is 20-30 min. It is excreted in bile as a monoglucuronide.
Indications for use of the drug KURANTIL®
- treatment and prevention of disorders cerebral circulation ischemic type;
- encephalopathy;
- primary and secondary prevention of coronary artery disease, especially in case of intolerance to acetylsalicylic acid;
- prevention of arterial and venous thrombosis and treatment of their complications;
- prevention of thromboembolism after heart valve replacement surgery;
- prevention of placental insufficiency during complicated pregnancy;
- microcirculation disorders of any type (as part of complex therapy);
- prevention and treatment of influenza, ARVI (as an interferon inducer and immunomodulator) - for taking the drug in a dose of 25 mg.
Dosage regimen
The dose of the drug is selected depending on the severity of the disease and the individual response of the patient.
For the prevention and treatment of cerebrovascular accidents, as well as for prophylaxis, 75 mg is prescribed 3-6 times a day. The maximum daily dose is 450 mg.
To reduce platelet aggregation, Curantil is prescribed at a dose of 75-225 mg per day in several doses. In severe cases, the dose can be increased to 600 mg per day.
For the prevention of influenza and ARVI, especially during epidemics, Curantil N25 and Curantil 25 are prescribed 50 mg (2 tablets or 2 dragees) per day in 1 dose. The drug is taken once a week for 4-5 weeks.
To prevent relapses of ARVI in patients who frequently suffer from respiratory viral infections, Curantil N25 and Curantil 25 are prescribed 100 mg per day (2 tablets or 2 tablets with an interval of 2 hours between doses). The drug is taken once a week for 8-10 weeks.
The tablets should be taken on an empty stomach, without breaking or biting, with a small amount of liquid. The duration of the course of treatment is determined by the doctor.
Side effect
From the cardiovascular system: palpitations, tachycardia (especially with the simultaneous use of other vasodilators), bradycardia, flushing of the face, flushing of the facial skin, coronary steal syndrome (when using the drug at a dose of more than 225 mg per day), decreased blood pressure.
From the digestive system: nausea, vomiting, diarrhea, pain in the epigastric region. These side effects usually disappear with longer use of the drug.
From the blood coagulation system: thrombocytopenia, changes in the functional properties of platelets, bleeding; in isolated cases - increased bleeding during or after surgery.
From the side of the central nervous system: dizziness, noise in the head, headache.
Allergic reactions: skin rash, urticaria.
Other: weakness, feeling of ear fullness, arthritis, myalgia, rhinitis.
When using the drug in therapeutic doses, side effects are usually mild and transient.
Contraindications to the use of the drug KURANTIL®
- acute myocardial infarction;
- unstable angina;
- widespread stenotic atherosclerosis of the coronary arteries;
- subaortic aortic stenosis;
- heart failure in the stage of decompensation;
- arterial hypotension;
- collapse;
- severe arterial hypertension;
- severe heart rhythm disturbances;
- chronic obstructive pulmonary diseases;
- chronic renal failure;
- liver failure;
- hemorrhagic diathesis;
- diseases with an increased risk of bleeding (including peptic ulcer of the stomach and duodenum);
- hypersensitivity to the components of the drug.
Use of the drug KURANTIL® during pregnancy and breastfeeding
The drug can be used during pregnancy according to indications.
The use of the drug during lactation is possible only if the expected benefit from treatment exceeds possible risk.
Use for liver dysfunction
Contraindicated in liver failure
Use for renal impairment
Contraindicated in chronic renal failure
special instructions
With simultaneous consumption of tea or coffee (contain xanthine derivatives), the vasodilatory effect of Curantil may decrease.
Use in pediatrics
Impact on the ability to drive vehicles and operate machinery
Caution should be exercised when driving vehicles and operating machinery, since as a result of a drop in blood pressure while taking Curantil, the ability to concentrate and speed of psychomotor reactions may deteriorate.
Overdose
Symptoms: decreased blood pressure, angina pectoris, tachycardia, feeling of hot flashes, weakness and dizziness.
Treatment: artificial vomiting, gastric lavage, prescription activated carbon. The vasoconstrictor effect of the drug can be stopped by slow (50-100 mg/min) intravenous administration of aminophylline. If symptoms of angina persist, prescribe sublingual nitroglycerin.
Drug interactions
When using Curantil simultaneously with anticoagulants or acetylsalicylic acid the antithrombotic effect of the latter increases and, accordingly, the risk of developing hemorrhagic complications.
With simultaneous use, Curantil enhances the effect of antihypertensive drugs.
At joint use Curantil may weaken the anticholinergic effects of cholinesterase inhibitors.
When used simultaneously, xanthine derivatives weaken the vasodilator effect of Curantil.
Conditions for dispensing from pharmacies
The drug is available with a prescription.
Storage conditions and periods
List B. The drug should be stored in a place protected from light, out of reach of children, at a temperature not exceeding 30°C. The shelf life of Kurantil N 25 and Kurantil N 75 is 3 years, Kurantil 25 is 5 years.
Curantil, relative to the pharmacotherapeutic group, belongs to antithrombotic drugs. On Russian market presented in the form of tablets: a package of 120 pieces with a dosage of 25 mg and a package of 40 pieces with a dosage of 75 mg and solutions.
The active ingredient of the drug is dipyridamole. Indications for use are treatment and prevention of cerebrovascular accidents, prevention of thrombosis and thromboembolism, discirculatory encephalopathy, prevention of placental insufficiency during pregnancy complications. The medicine is also used as part of complex therapy for microcirculation disorders.
Note! Use Curantil and all medications containing dipyridamole only as prescribed by a doctor.
Since the drug is imported, its price is quite high: from 550 to 590 rubles. Against this background, questions arise: how to replace such an expensive medicine; are there close substitutes?
Today the pharmaceutical market offers patients the opportunity to purchase inexpensive drugs, which contain a similar active substance and give comparatively the same therapeutic effect.
They are called analogues (synonym - generics). Those that are cheaper are represented by companies of domestic production, Belarusian and Ukrainian production.
Note! Using analog medicines in dosages prescribed by a doctor, possibly without consulting a doctor. Analogues show the same therapeutic effectiveness.
The table shows a list of modern and cheap analogues of the drug.
| Drug name | average price in rubles | a brief description of |
| Dipyridamole Manufacturer: Borshchagovskiy HFZ | 320 – 00 | Belorussian inexpensive analogue, one of the best substitutes. Available in the form of tablets with a dosage of 25, 50, 75 mg of active substance and solutions. Suitable for the prevention of thrombosis and treatment of angina pectoris. Duration of use is from 2 weeks to a month, 1-3 tablets 3 times a day. |
| Dipyridamole Manufacturer: Ozon LLC | 290-00 | Most cheap analogue Russian production. Finds its use in treatment ischemic stroke, prevention of thromboembolism after heart surgery. Contraindications include hypersensitivity to active component, arterial hypertension, severe forms of arrhythmia. Do not use by pregnant women under 12 weeks. |
| Persad | 380-00 | Cheap generic. Used for the treatment and prevention of influenza and acute respiratory diseases; as an antithrombotic agent; as an analogue of Curantil during pregnancy. Among the contraindications: childhood up to 12 years, lactation period, first trimester of pregnancy. Do not use to treat people with medical conditions gastrointestinal tract in the acute phase, with gastric ulcer. |
| Trombonil | 420-00 | The drug is able to inhibit platelet adhesion and affect their primary and secondary adhesion. Used during pregnancy in cases of placental circulatory and microcirculation disorders. Prevents fetal hypoxia by improving the supply of oxygen through the placenta. Application lasts 4-6 weeks, 1 tablet (25 mg) three times a day. Able to enhance the effect of blood pressure lowering agents. |
| Persantine | 390-00 | Angioprotector, microcirculation corrector, immunomodulator. Contraindications include acute renal failure, angina pectoris, and heart rhythm disturbances. |
| Alo-Dipyridamole | 420-00 | Available in tablet form. Serves as a dilator of arterioles, causes changes in blood flow speed upward, and improves the rate of oxygen supply to organs. Use with caution to treat patients who suffer from heart failure or high blood pressure. Not used in pediatric therapy. Contraindicated in case of acute allergic reactions to the active component. |
| Vero-Dipyridamole | 350-00 | Used for the treatment of chronic obliterating diseases blood vessels lower limbs, at complex treatment glomerulonephritis, childhood syndrome suppression of platelet activity. Increases the body's immune reactivity. Contraindicated in atherosclerosis of the coronary arteries, peptic ulcer intestines, diathesis, individual intolerance to components. |
| Sanomil-Sanovel | 460-00 | Used in the treatment of disorders of blood circulation in the brain. Effective for progressive forms of atherosclerosis. Reduces the risk of stroke by 40%. Contraindicated for use in patients with acute allergic reaction to the active component. IN antiviral prophylaxis affects human interferons, enhancing protective immune reactions and alleviating the course of the disease (25 mg once a day for 7-10 days). |
| Penseline | 410-00 | Generic made in Japan. Prescription antiplatelet, arteriodelatizing drug. Reduces the rate of platelet adhesion, stimulates the effectiveness of postacyclin. Normalizes the outflow of venous blood. Has a positive effect on the microcirculation of the retina. Used to prevent thrombosis of implants. Not used for obstructive pulmonary diseases, hypotension. |
All of the listed drugs are complete structural and functional substitutes for the drug Curantil: the composition of the drugs is absolutely identical; indications for use, contraindications and adverse reactions are similar; the quality is at the same level.
- Related Posts
The drug has been known in medicine for many years. Its use has been verified not only by research, but also by patient experience.
The active substance included in the medication is dipyridamole. The medicine is produced in the form of tablets with different dosages dipyridamole (25/50/75/100 mg). The dosage of the drug has a major influence on the indication for use.
"Curantil" is produced in a package with a glass bottle containing 40/100/120 tablets.
The drug Curantil is an anticoagulant, the action of which is due to active substance drug
Pharmacological properties
As a result of taking "Curantil":
- the blood vessels of the heart dilate;
- blood circulation accelerates;
- blood volume increases;
- oxygen supply to the heart improves.
Systematic use of the drug prevents the formation of blood clots and subsequent blockage of blood vessels. Tablets are also recommended during pregnancy to prevent blockage of the placental vessels that provide blood supply to the fetus.
The instructions for use also include an immunomodulatory effect among the peculiarities of the action of Curantil tablets. Dipyridamole enhances the synthesis and activity of interferon, which leads to an increase in the body's resistance to the effects of viral diseases.
Prevention of placental insufficiency during complicated pregnancyAfter taking Curantil, dipyridamole dissolves in the stomach and enters the blood. The highest concentration of the substance is observed an hour after consuming the drug. With regular use of tablets, dipyridamole accumulates in the body, due to which its properties are maximized.
Indications
The action of the drug is aimed at improving the functionality of the circulatory system and enriching the composition of the blood.
In this regard, the indications for the use of "Curantil" include:
- encephalopathy (dyscirculatory form);
- ischemic cerebrovascular accident;
- diseases caused by viruses (flu or ARVI);
- violation of general blood microcirculation.
For the purpose of prevention, taking "Curantil" is prescribed if there is a risk of developing:
- thrombosis (arterial or venous);
- complications of thrombophlebitis;
- ischemic form of heart disease;
- thromboembolism after installation of prosthetic heart valves.
Quite often, the use of “Curantil” is resorted to in the treatment of diseases of the cardiovascular system, in cases where the patient is sensitive to acetylsalicylic acid drugs.
Contraindications
The composition of the tablets can provoke an exacerbation of certain diseases, as well as cause pathological processes with intolerance to the constituent substances.
Contraindications to the use of the drug are: acute myocardial infarction; unstable angina- myocardial infarction;
- attacks of ischemic heart disease;
- vascular atherosclerosis;
- decompensating form of heart failure;
- subaortic stenosis;
- arterial hypotension;
- heart rate abnormalities;
- collapse.
Contraindications to the use of "Curantil" are also:
- kidney/liver failure;
- pulmonary obstruction;
- hemorrhoidal diathesis;
- impaired blood clotting.
The drug is not contraindicated for treatment during pregnancy and breastfeeding.
Side effect
Curantil should be taken only if there are no contraindications. Side effects in most cases occur precisely because the patient has concomitant diseases, in which the effect of the drug causes an exacerbation.
Feeling of heat, decreased blood pressure, tachycardia, headache, general weakness, dizzinessThe side effect as a result of taking "Curantil" is expressed in the form of symptoms:
- changes in heart rhythm and pressure surges;
- dysfunctions of the gastrointestinal tract;
- bleeding;
- migraine;
- skin allergies;
- arthritis;
- rhinitis;
- hearing impairment;
- myalgia;
- increased weakness.
If the patient develops obvious symptoms of side effects, the medication is discontinued and an analogue of the drug is prescribed.
Overdose
When prescribing Kurantil, the doctor must clearly indicate daily dose which the patient must take. Even a slight excess of the dosage of the drug often causes intoxication with the composition of the drugs.
Symptoms of an overdose of the drug Curantil: decreased blood pressure, angina pectoris, tachycardiaSymptoms:
- hypotension;
- vasodilation;
- tachycardia;
- false sensation of rising temperature.
General clinical picture supplemented by signs side effect.
In case of overdose, be sure to stop taking the drug pills and take measures to treat drug intoxication.
In case of severe symptoms of overdose, it is better to contact medical institution or call an ambulance. In case of mild intoxication, you can limit yourself to gastric lavage. In a hospital setting, the patient is administered Aminophylline intravenously.
Instructions
Treatment of vascular diseases with this medication is carried out depending on the dosage. The tablets are taken before breakfast (on an empty stomach). The dragee should be taken with water. The general treatment regimen for pathologies presented in the instructions for use of "Curantil" involves taking the drug by adults and children over the age of 12 years. For children younger age dragees are prescribed according to an individual scheme.
When used simultaneously with anticoagulants or acetylsalicylic acid, it is recommended to prescribe Curantil at a dose of 75 mg 3 to 6 times a day- For cardiac ischemia, tablets are prescribed in a dosage of 235 mg. The medication is taken three times a day, 1 tablet. (75 mg). The specialist may increase the daily dose to 450 mg if indicated.
- To reduce platelet adhesion, the drug is prescribed at a dose of 75 mg 3 times a day. The maximum daily dose is 600 mg.
- To prevent viral infections, you are prescribed to drink 2 tablets for a month. (25 or 75 mg) per day in one dose. To prevent relapse, it is recommended to take 2 tablets of the medicine. (25/75 mg) twice a day at two-hour intervals for two months.
The treatment regimen indicated in the annotation is general, so you should consult a doctor who will determine the frequency of taking the medication and the course of therapy according to the indications and the general clinical picture.
During pregnancy and lactation
When the drug is prescribed to an expectant mother, the gynecologist must explain to the patient how Curantil works during pregnancy and why it is prescribed. In most cases, taking medications is not recommended for pregnant women. However, the instructions for use during pregnancy for the drug “Curantil” indicate that studies have been conducted that have confirmed the safety of the tablets regarding the health of the fetus.
Curantil is not contraindicated during pregnancy, however, before prescribing it, it is necessary to compare the possible risks and potential benefitsWhen planning pregnancy or during pregnancy, a woman is prescribed a medicine in a dosage of 25 mg. The daily dose should not be increased. According to the instructions for use of "Curantil", the pills are consumed on an empty stomach or 2 hours after a meal. According to a similar scheme, the medicine is prescribed during lactation.
It is important to follow all the rules for prescribing "Curantil". It should be remembered that exceeding the dosage can cause side effect, which will affect the development of the fetus.
special instructions
- It is not advisable to drink the pills with coffee or tea due to the risk of reducing the vasodilating effect of the medicine.
- Children under 12 years of age are prescribed the drug only when difficult cases pathologies of the circulatory system.
- The medication affects concentration, so you should drive with caution during therapy.
- Combination with alcohol increases the risk of side effects.
- In case of renal/liver failure, the drug is prescribed only under the condition of constant supervision by a specialist.
The prescription of "Curantil" in pediatrics and gynecology is carried out taking into account the risk of side effects, in connection with this the patient is warned about strict adherence to the instructions regarding the dosage of the drug.
Drug interactions
The simultaneous administration of Curantil and other drugs may lead to a decrease in the effect of one of the drugs and to the occurrence of side effects.
The vasodilator medication should not be taken simultaneously with the following groups of drugs:
- xanthine;
- antacids;
- cholinesterase;
- cephalosporins;
- anticoagulants.
The simultaneous use of acetylsalicylic acid and Dipyridamole leads to bleeding due to enhanced vasodilating and blood-thinning effects. In addition to acetylsalicylic acid, it is not recommended to combine the main treatment with the use of Heparin.
Agrenox capsules Analogues
If it is necessary to replace "Curantil", analogues are selected by the attending physician. There are many analogues and generics to the original remedy. When replacing a drug, first of all, you should pay attention to medications with a similar active ingredient and pharmacological properties. Complete analogue considered "Dipyridamole".
The medicine can also be replaced with:
- "Persantine";
- "Trombonil";
- "Parsedyl";
- "Sanomil-Sanovel";
- "Agrenox".
The main difference between these drugs is the manufacturer, release form and price.
There are other medications that have a different active ingredient, but have a similar effect on the body. Analogues of this group are recommended in case of a side effect in a patient caused by the body’s reaction to the composition of the original.
Which is better – “Dipyridamole” or “Curantil”
Even a doctor will not give a definite answer. In this case, everything depends on the individual reaction of the body, since the composition of the drugs does not differ significantly.
According to statistics, Dipyridamole more often causes side effects, but the cost of the medicine is slightly lower than the original - from 460 rubles for 120 tablets. What exactly to take is decided by the doctor, since both drugs are prescription drugs, and without a doctor’s prescription it will not be possible to purchase them at the pharmacy.
Cost and where to buy
In pharmacies, "Curantil" is sold exclusively with a prescription issued by the attending physician. Due to the impact on circulatory system and the presence of contraindications, the medication is classified as a prescription drug. Depending on the dosage of dipyridamole in the composition of Curantil tablets, the price varies. The average cost of a 25 mg tablet is 550 rubles, and a drug with a dose of 75 mg costs 650 rubles.
The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!
The drug Curantil
Chimes has been known on the pharmaceutical market for a long time. It is used as an antianginal (antiangina drug), antiplatelet (antithrombotic) and angioprotective (protects blood vessels) agent.Curantil has a vasodilating effect mainly on the small vessels of the heart, but in large doses it reduces resistance in the arterioles of the whole body and leads to a decrease in blood pressure. By expanding the diameter of blood vessels, blood circulation increases and the flow of oxygen to cells improves, therefore, the damaging effect of hypoxia or ischemia, which often occurs in heart disease, is neutralized. Curantil promotes the formation of collaterals (bypass paths) in ischemic areas, improves the functioning of the heart muscle, and reduces blood pressure.
Curantil improves microcirculation in the vessels of the brain, retina, and kidneys. During pregnancy, it slows down degenerative processes in the placenta, eliminates hypoxia of fetal tissue and restores placental blood circulation.
In addition, the drug prevents platelet aggregation and the formation of blood clots, especially when taken in combination with Curantil and acetylsalicylic acid. With an increase in a single dose of the drug, a shortening of the lifespan of platelets and a suppression of the tendency to thrombus formation are observed. This effect is used in the treatment of patients with deep vein thrombosis. The combined use of Curantyl and acetylsalicylic acid is quite often prescribed in the complex treatment of atherosclerosis, as well as to reduce the risk of developing a recurrent stroke in patients with ischemic stroke.
The main active ingredient of Curantil is dipyridamole, which helps to increase the production of interferon, a protein that has a pronounced antiviral effect. In this regard, Curantil can be used as a drug that increases the body's resistance to viral infections.
And the last area of application of Curantil is stress echocardiography and dipyridamole-thallium-201 perfusion scintigraphy in the diagnosis of coronary heart disease in patients with unchanged coronary vessels. IN in this case the drug is used as a diagnostic tool to determine the condition of the heart muscle, the safety of the valve apparatus and its contractile activity.
Release forms
Curantil is available in tablets, dragees and solutions for intravenous administration. Pills yellow or greenish-yellow in color, covered with a shell. Each tablet contains 25, 50, 75 or 100 mg of the active ingredient dipyridamole. Depending on this, the drug is called Curantil 25, Curantil 50, Curantil 75 or Curantil 100.
Dragee contain 25 or 75 mg dipyridamole. Usually dragees are packaged in glass jars of 100 pieces.
In ampoules A 0.5% dipyridamole solution is available. Each 2 ml ampoule contains 0.01 g of active ingredient.
Instructions for use of Curantil
Indications for use
Curantil is prescribed to adults and children over 12 years of age who have vascular disorders in the brain, retina, heart, kidneys, deep vessels of the extremities. In obstetric practice, it is used for circulatory disorders in the placenta and deterioration of the fetal nutritional conditions. The main indications for prescribing Curantil are:
- Treatment of coronary heart disease, subacute myocardial infarction or post-infarction condition, stable angina, especially with intolerance to acetylsalicylic acid. For these diseases, Curantil can also be prescribed for prophylactic purposes.
- Prevention of thromboembolism and thrombosis of arteries and veins in postoperative period when replacing heart valves.
- Common atherosclerosis of heart vessels.
- Heart failure in the compensation stage.
- Hypertension II degree and higher.
- Deterioration of placental circulation, fetal hypoxia, placental insufficiency.
- Chronic cerebrovascular insufficiency, cerebral infarction, discirculatory encephalopathy.
- As part of complex treatment for various microcirculatory disorders.
- As an immunomodulatory drug (to enhance immunity) during periods of influenza and ARVI epidemics.
Contraindications
Any acute conditions caused by impaired microcirculation, unstable or decompensated diseases, as well as increased bleeding are contraindications for the use of Curantil.The drug is not prescribed to children under 12 years of age, because there is not enough data on its harmlessness to the child’s body.
The drug is not prescribed for the following diseases or states:
- Acute cerebral or myocardial infarction;
- Acute or unstable course of angina;
- Cardiac, renal, liver failure in the stage of decompensation;
- Arterial hypotension, collapse, fainting;
- Vegetative-vascular dystonia of the hypotonic type;
- Heart rhythm disturbances - ventricular arrhythmias, atrial fibrillation etc.;
- Obstructive diseases of the bronchopulmonary system;
- Subvalvular (subaortic) aortic stenosis;
- Common coronary sclerosis;
- Tendency to spontaneous bleeding, presence of peptic ulcer (due to possible development bleeding), hemorrhagic diathesis;
- Intolerance to any of the components of the drug.
Side effects
Side effects while taking Curantil occur quite rarely. Among them, the main place is occupied by dyspeptic symptoms - nausea, occasionally vomiting and diarrhea. Complaints of headache or muscle pain, weakness and dizziness may appear. People with a tendency to arterial hypotension are likely to develop fainting and/or an increase in heart rate up to 90 times per minute or more.In some cases, the phenomenon of cardiac “stealing” occurs - retrograde movement blood along collaterals, bypassing narrowed coronary vessels. Withdrawal syndrome may also develop with the development of unstable angina or myocardial infarction. This phenomenon usually occurs when long-term treatment Chimes.
Extremely rare adverse reactions are urticaria and bronchospasm, as well as changes in the blood, in particular a decrease in the number of platelets (thrombocytopenia).
Unlike acetylsalicylic acid (aspirin), Curantil does not cause ulceration in the gastrointestinal tract.
Treatment with Curantil
The doctor selects the dosage and duration of taking Curantil individually, based on the form of the disease, the severity of its course and the patient’s sensitivity to the drug. If necessary, the drug can be taken long time, in some cases - up to 10 weeks or more.Self-prescription of the drug is not allowed, due to the fact that its incorrect or unreasonable use can worsen the patient’s condition. Curantil is a prescription drug.
How to take Curantil?
The drug is taken before meals or 1.5-2 hours after meals. The tablet or pill should not be chewed; it must be swallowed with a sufficient amount of still water.
Curantil dosage
The maximum daily dose of the drug is 600 mg, it is prescribed only during treatment severe violations. When taking Curantil simultaneously with anticoagulants or acetylsalicylic acid, the dose of Curantil is halved.
Depending on the nature of the disease, Curantil can be prescribed in the following dosages:
1.
For coronary heart disease, the initial daily dose of the drug is 225 mg. The dose is divided into 3 doses.
2.
For cerebrovascular accidents, Curantil is prescribed 75 mg 3 to 6 times a day.
3.
As an antiplatelet agent, Curantil is prescribed 3-6 tablets per day, dividing the dose into several doses. If necessary, the daily dose can be increased to 8-9 tablets.
4.
During an epidemic of influenza and ARVI, Curantil is taken 1-2 tablets once a week for 1.5 months. To increase immunity in frequently ill people, the drug is prescribed at a dose of 100 mg per week (the dose is taken in 2 doses, the interval between doses is 2 hours) for a period of up to 8-10 weeks.
Chimes during pregnancy
Curantil can be taken during pregnancy, it does not have any negative impact for the fruit. However, in the 2nd and 3rd trimesters it should be taken with extreme caution and if there are clear indications for this. Most often, Curantil is prescribed to pregnant women for placental insufficiency, late toxicosis, concomitant cardiovascular and renal pathology, premature aging of the placenta, post-term pregnancy.
Curantil can also be used to increase nonspecific immunity in pregnant women during dangerous periods. viral diseases periods or with frequent exacerbations of existing chronic viral infection(eg genital herpes).
Interaction of Curantyl with other drugs
During treatment with Curantil, it is not advisable to drink drinks containing caffeine (coffee, cocoa, tea, mate, Coca-Cola, Pepsi-Cola), as well as take the drug diuretin. These substances can significantly reduce or neutralize the completely positive effects of Curantil.At simultaneous treatment Curantil and indirect anticoagulants (drugs that reduce blood clotting), as well as acetylsalicylic acid, the dose of Curantil should be reduced, because its activity increases sharply and there is a risk of spontaneous bleeding.
Curantil may enhance the effect of drugs prescribed to lower blood pressure. And, on the contrary, when using Curantil and drugs for the treatment of Alzheimer's disease, dementia, myasthenia gravis, a decrease in the activity of the latter is observed.
The simultaneous use of Curantil and cephalosporin antibiotics (Cefamandol, Cefoperazone, Cefotetan) leads to an increase in the antiplatelet properties of Curantil.
Antacids used for increased acid-forming function of the stomach reduce the absorption of Curantil, which causes a decrease in the therapeutic effect.
It is not allowed to mix Curantil solution for intravenous injections with others injectable drugs due to the fact that an insoluble precipitate may form. You cannot mix Curantyl solution with Actovegin, because the latter can cause anaphylaxis. However, tablet forms of Curantil and Actovegin are often prescribed in the complex treatment of microcirculatory disorders of various origins.
Curantil's analogs
Curantil has quite a lot of analogues. Depending on the country and manufacturer, the drug is produced under the following trade names: - Dipyridamole;
- Parsedyl;
- Persantine;
- Trombonil;
- Sanomil-Sanovel;
- Anginal;
- Antistenocardin;
- Trancocard;
- Apricor;
- Cardioflux;
- Coribon;
- Trombonil;
- Viscor;
- Vadinar.
