What is better: Legalon or Essentiale? Hepatoprotectors: a complete list of drugs with proven effectiveness and price (inexpensive and expensive drugs)

The liver is an important gland that performs many functions. The parenchymal organ synthesizes various substances, participates in the processes of hematopoiesis, retains reserves of certain vitamins and energy substances, neutralizes and removes toxins. But alcohol abuse, long-term use of medications, poor diet, stress and genetic diseases disrupt the functioning of the gland. Various drugs are used to restore the functioning of the organ.

The best medicines for the liver are hepatoprotectors. Today, products such as Liv 52 or Karsil are often used. To determine which of these drugs is better, you need to familiarize yourself with the characteristics of the medications.

The hepatoprotector is produced in the form of tablets. The leading components of the drug are plant extracts (chicory, yarrow, nightshade, cassia). Substances protect the gland membrane and promote its restoration.

This drug is used for liver dysfunction:

• Hepatitis
• Cirrhosis
• Hepatosis
• Cholecystitis.

Liv 53 tablets are taken orally 30 minutes before meals. For the purpose of prevention, the medicine is taken twice a day, 2 pills.

When treating children, the dosage does not change. If adult patients are being treated, take up to 3 tablets three times a day.

After taking a hepatoprotector, it is possible to develop adverse reactions in the form of allergies and disruption of the gastrointestinal tract.

Contraindications to taking Liv 52 are blood diseases, hypersensitivity, pregnancy and lactation.

Dragees differ in plant composition. The main component of the hepatoprotector, milk thistle, has an antioxidant, detoxifying and regenerating effect.

Can be used to treat cirrhosis, toxic lesions and chronic inflammation occurring in the liver.

Instructions for use:

• 1 tablet three times a day.
• The average treatment time is 30 days.

Possible adverse reactions Karsila – frequent urination, digestive disorders, shortness of breath, allergies, vestibular disorders. Contraindications – age under 12 years, acute poisoning.

Comparison

It is difficult to make a choice between the drug Karsil and Liv 52. Both drugs are equally effective at protecting the liver from harmful substances.

But hepatoprotectors have some differences. Thus, the therapeutic effect of Liv 52 may decrease with its joint use with a number of medications. The advantage of Karsil is that the tablets can be combined with any medications.

However, Karsil increases the effectiveness of Diazepam. Therefore, before combining drugs, you need to consult your doctor.

There are many analogues that can replace Liv 52 and Karsil. These are Maksar, Hofitol, Heptral, Legalon, Essentiale, Rezalut, Gepabene, Ursofalk, Phosphogliv, Ursosan. To understand which of these hepatoprotectors is better, it is necessary to compare them.

To find out what doctors think is better, Maxar or Heptral, you need to read the doctors’ reviews. The opinions of hepatologists vary. The drug Maxar is a strong hepatoprotector, but it is not sold in pharmacy chains. You can only order the medicine on the Internet, which raises doubts among many doctors about the therapeutic effect of the drug.

When choosing between Heptral or Essentiale, it is worth considering the fact that hepatoprotectors belong to different categories. The first remedy is used to treat severe illness liver. Due to the powerful effect of the medicine, it is prohibited to use it before the age of 18.

Essentiale has a milder effect. The main functions of the tablets are restoration and maintenance of the gland. Therefore, the drug can be prescribed from the age of three.

Doctors know which is better: Heptral or Phosphogliv. Hepatologists prefer the latter drug, which not only restores hepatocytes, but also relieves inflammation. When choosing between Phosphogliv or Heptral, it is worth considering that the latter remedy has many more contraindications and adverse reactions.

Comparing Gepabene or Essentiale, doctors say which is better last drug. Essentiale has a much larger list of indications. In view of this, gastroenterologists consider the medicine to be more effective than Gepabene.

When comparing Heptral or Ursosan, hepatologists draw attention to the fact that the drugs have different active ingredients - S-adenosylmethionine and ursodeoxycholic acid. The first drug is contraindicated for children, and the second can be taken from the age of three.

Phosphogliv or Karsil, which is what hepatologists know best. Doctors recommend choosing the first medicine. Phosphogliv effectively treats liver diseases, relieves inflammation, restores the organ and prevents the development of diseases in the future.

Rezalut or Heptral are also often compared. Both drugs are quite effective, so the choice must be made by the attending physician based on the patient’s particular body.

Ursosan or Essentiale: which is better to take? Most people with liver disease are convinced that ursodeoxycholic acid is much more effective than herbal components. Therefore, patients prefer Ursosan, the price of which is much lower than Essential.

Doctors do not know which is better than Legalon and Phosphogliv, since the drugs have almost the same effectiveness. In this regard, doctors often recommend taking these drugs alternately.

Hofitol and Karsil have a plant composition. But the artichoke-based drug has many more contraindications. The cost of drugs is approximately the same.

People suffering from cirrhosis or hepatosis and their treating doctors do not know which is better than Hepabene or Essentiale Forte. Both hepatoprotectors are effective and safe, which makes them one of the best remedies in the fight against liver diseases.

Ursofalk and Heptral: which is better for the treatment of cirrhosis and severe gland pathologies? Reviews say that the first drug is much more effective, but it can only be taken as prescribed by a doctor. Heptral is a less effective remedy, and its cost is too high.

If we talk about which is better Phosphogliv or Liv 52, then doctors pay attention to different groups drugs. The first remedy is an essential phospholipid, and the second is a plant hepatoprotector. In terms of effectiveness, Phosphogliv is considered stronger, which allows it to be used to treat advanced forms of liver diseases. Liv 52 is prescribed for mild disorders of the gland. It is also used as a support agent when taking toxic medications.

Updated: 03/23/2020

The liver is the largest gland. Takes part in digestion and neutralization of harmful substances. Responsible for the production of bilirubin, cholesterol, enzymes and hormones. Capable of storing blood and glucose. Any disturbances in the functioning of the organ are manifested by poor health.

Characteristic signs of a malfunction are bloating, pain, poor digestion. May harm the liver junk food, poor environmental conditions, unhealthy lifestyle. If you need treatment or want to carry out prevention, check out the rating of the best drugs for the liver. You will learn the opinions of customers and experienced professionals. Before taking, be sure to consult your doctor.

Essential phospholipids

Pharmaceutical companies offer several medical supplies containing polyunsaturated (essential) fatty acid. The components have metabolic and hepatoprotective properties. They are used to treat liver diseases.

Designed to restore organ structure in cases of hepatitis, fatty degeneration and cirrhosis. Manufacturers also claim that phospholipids have additional properties: they improve metabolism, reduce the likelihood of developing atherosclerosis, improve skin condition, and help after radiation.

Advantages

• Drugs for liver restoration are well tolerated by patients.
• Reduce the likelihood of disease recurrence.
• They help as a complex drug in the treatment of hepatitis C.
• Easy to digest.
• Prescribed even during pregnancy.
• Reduce liver costs.
• Improves enzyme activity and physicochemical parameters of bile.

Flaws

• After intravenous injection pain may occur.
• They do not restore liver cells, but only cell walls.
• For maximum results, the course of treatment should be at least 6 months.
• Do not take simultaneously with medications containing vitamin B.
• They can activate the inflammatory process.
• High price.

Rating of the best essential phospholipids

Hepatoprotector. A complex of vitamins, amino acids, essential phospholipids and plant extracts that protect and support liver cells, and also help restore already damaged liver structure (including after hepatitis).

Helps the body as a whole in the fight against harmful factors (alcohol, heavy metals, poisoning, unhealthy diet, etc.) and diseases.

Capsules (90 pcs.).

• Provides 4-component comprehensive liver protection
• Helps gently cleanse the liver of toxins
• Protects the liver from adverse factors
• Promotes natural regeneration of liver cells
• Improves metabolism and restores liver function
• The components of the composition have been well studied and have a favorable safety profile.

• Not available for sale in all regions
• Contraindications: pregnancy, breastfeeding, individual intolerance to the components.

Hepatoprotective, antiviral agent with a combined composition. Contains simultaneously two active components - phospholipids and glycyrrhizic acid.

Has a regenerative effect. Restores the functions and structure of membranes.

It also has cytoprotective properties. Normalizes protein and lipid metabolism.

Produced in capsules for oral use. The best effect is achieved when taking the drug with food.

Prescribed for viral hepatitis (both chronic and acute forms), toxic damage and cirrhosis of the liver. As an auxiliary component it can be used in the treatment of neurodermatitis, intoxication, psoriasis, eczema.

• Prevents loss of enzymes.
• Stimulates liver function.
• Promotes the formation connective tissue.
• Reduces the risk of cirrhosis and fibrosis.
• Well tolerated by the body.
• Contains plant components.
• Cheaper than analogues.
• Increases the body's protective function.
• Eliminates pain in the right hypochondrium.
• Small capsules.

• There are side effects.
• Increases blood pressure.
• Duration of treatment.

Dietary supplement helps replenish the body's need for vitamin E and essential phospholipids. This improves the state of the antioxidant system and normalizes liver function.

Metabolism is optimized. The drug protects cell membranes from oxidation.

Supports the functioning of the nervous system. Gepagard is also prescribed for low body resistance to toxins.

For achievement therapeutic effect You must take two capsules with meals. During the day you need to drink the dietary supplement 2 times.

The course of treatment is one month.

• Accelerates cell regeneration.
• Improves metabolism.
• Normalizes the functioning of the digestive tract.
• Improves memory.
• Normalizes the conductivity of impulses.
• Safe composition.
• Affordable price.
• Easy to take.

• A small number of capsules in one package.

One of the effective hepatoprotectors. Has a combined effect.

Contains essential phospholipids and milk thistle. One capsule of the drug contains seventy milligrams of silymar and from one hundred to two hundred milligrams of lipoid.

It also contains additional components. One package contains 30 light orange capsules.

Normalizes the exchange of proteins, phospholipids and lipids. Helps digest food and activates enzyme production.

Stabilizes cell membranes. Protects cells from destruction.

Accelerates regeneration and excretion of bile. Prevents the formation of connective tissue.

• Removes toxins from the body.
• Has antioxidant properties.
• There are virtually no contraindications or side effects.
• Protects tissues from toxic damage.
• Restores the structure and functions of the liver.

• During the day you need to take about 6 capsules.
• High cost of the drug.

The drug was created to prevent acute liver diseases. It also stops the progression of existing chronic ailments.

Helps to lead a healthy lifestyle during chronic hepatitis and cirrhosis. Regulates carbohydrate and fat balance.

Has a detoxifying effect. Like other hepatoprotectors, it is prescribed in combination to eliminate organ damage.

Contains fat metabolism products and B vitamins, including pyridoxine hydrochloride, riboflavin, cyanocobalamin, thiamine mononitrate. Helps the body cope with heavy foods - broths, mayonnaise, fatty and fried foods, cakes with cream and alcohol.

• Helps remove toxins and waste.
• Affordable price compared to foreign analogues.
• Improves blood counts. Proven by ALT test results.
• Supports the body during a diet.
• Can be taken by children.
• It helps within a few days after the first use.

• Fragile capsules.
• Not produced in ampoules.
• There are contraindications.
• May cause side effects.
• To consolidate the result you need to take it for several months.

The drugs are created for the prevention and treatment of the liver. Capable of changing the cellular structure of an organ.

They improve the density of membranes and also restore their functionality. Capable of removing severe symptoms diseases after a short time, improve health.

The composition includes linoleic and linolenic acid. One package contains 30 capsules.

Each of which contains 6 milligrams of thiamine, 3 thousand milligrams of essential phospholipids and 6 milligrams of riboflavin.

In addition to these active substances, there are also auxiliary components. .

• Contains no vitamins. The therapeutic effect is provided by hepatoprotectors.
• Unlike classic multivitamin complexes, the drug can be taken for a long time without harm to health.
• Has a detoxifying effect.
• Relieves cirrhosis of the liver.
• Safe composition.
• Slows down the inflammatory process and reduces the degree of tissue necrosis.
• Improves the general condition of the digestive tract and overall well-being.
• Available without a prescription.
• Can be bought at any pharmacy.
• Suitable for treatment during pregnancy.

• For a stable and long-lasting effect, you need to take the drug for 3 to 12 months.
• Not prescribed for children.
• Contraindicated in case of individual intolerance to phosphatidylcholine.

Rating of the best solutions of low molecular sugars

The drug is designed to provide comprehensive support for liver function. Heptrong has an antioxidant effect; it contains low molecular weight sugars obtained from a natural beekeeping product - honey.

The active components protect the organ and reduce the cellular permeability of its tissues. This hepatoprotector is indicated for use by people suffering from liver damage of various origins: alcoholic, medicinal and other toxic.

• works as an antioxidant
• allowed for pregnant women
• can be taken for any severity of the problem
• reduces the intensity of inflammation
• completely decomposes to water and carbon dioxide
• well tolerated, without pain at injection sites

• Only injection form
• Not suitable for people with allergies to bee stings, honey and other honey derivatives

The main purpose of the drug is to restore the functioning of the liver, for which it is an antispasmodic and choleretic agent. Its effect is noticeable even with serious pathologies, for example, cirrhosis of the liver.

In addition, Heptral has a sedative and antidepressant effect on the patient, which is necessary in the acute phase of the disease. The medicine is also effective for certain brain pathologies.

The effect of the drug is associated with its accumulation in the body. Therefore, you should not expect a quick effect that occurs immediately after taking it.

• Indications for use:
• Cholangitis (infectious inflammation of the bile ducts).
• Fatty liver degeneration.
• Cirrhosis of the liver.
• Chronic hepatitis.
• Withdrawal syndrome, including alcoholic.

• May cause headaches, dizziness, and confusion.
• Possible side effects - increased sweating, rash, itching, allergic reactions
• May cause muscle spasms and joint pain.

The drug has a hepatoprotective effect and accelerates the transition of anaerobic processes to aerobic ones. Its intake improves the energy supply of hepatocytes, restores the activity of antioxidant enzymes, and increases the resistance of hepatocyte membranes to lipid peroxidation.

• Indications for use:
• Alcoholic hepatitis
• Toxic hepatitis
• Drug-induced hepatitis.
• Functional disorders liver associated with its acute or chronic diseases

• Possible metabolic disorders associated with activation of aerobic processes (
• Unpleasant sensations when administering the drug
• Allergic reactions are possible (rash, itchy skin).
• Possible nausea, headache, dizziness.

Herbal preparations for the liver

According to experts, best medicines of plant origin contain milk thistle. These include “Karsil”, “Legalon”, “Silimar”, “Gepabene”, “Sibektan”. Basics active substance such drugs are silymarin. Combines three compounds - silydianin, silicristin and silibinin.

It has antioxidant and membrane-stabilizing properties. Counteracts liver stress (oxidative). Has an immunomodulatory effect. Protects the organ from alcoholic illness. With prolonged use - about six months, the number of cytotoxic lymphocytes and the production of gamma globulin decreases. Minimizes cell susceptibility to toxic substances.

Advantages

• Natural composition.
• Promote cell regeneration.
• Stimulate protein synthesis.
• They have a choleretic effect.
• Increases the secretion of bile acids.
• Eliminate spasm biliary tract.
• Can be used for prevention.
• They have a strong antioxidant effect.

Flaws

• Manufacturers, in addition to milk thistle, may use other, less safe components.
• The course of treatment is usually at least 3 months.
• The effectiveness of drugs during the treatment of acute hepatitis or alcoholic impairment has not been clinically proven.

Rating of the best drugs for the liver of plant origin

The drug contains extracts of St. John's wort, common tansy and milk thistle. Helps in the treatment of alcoholic fatty liver disease, alcoholic liver disease, alcoholic cirrhosis of the liver, chronic cholecystitis and chronic persistent hepatitis.

It has hepatoprotective, membrane-stabilizing, antioxidant and choleretic effects. Has a mild effect.

Doctors also prescribe the drug in combination with others to restore liver cell membranes and have a better antioxidant effect. "Sibektan" also additionally has a tonic property.

Relieves depression, improves the functioning of the digestive tract. Clinically proven anti-inflammatory and antibacterial properties.

For maximum effectiveness, take on an empty stomach half an hour before meals. The daily dose should not exceed 800 milligrams.

The standard course of treatment is 20 weeks. According to the doctor's decision, it will need to be repeated after 2 or 3 weeks.

• Renders complex action. May help with peptic ulcers, gastritis or kidney disease.
• Does not cause overdose.
• Safe composition.
• Various release forms.

• You need to take a lot of pills throughout the day. We'll have to get used to the new regime.
• There are contraindications.
• Not prescribed under 18 years of age.

The medicinal product contains herbal components. It has antitoxic and hepatoprotective properties.

Developed for the treatment of liver cirrhosis, toxic damage to the organ, as well as for recovery from hepatitis. Prescribed as a prophylaxis for chronic intoxication.

With prolonged use of medications and alcohol abuse. The medicine should be taken before meals, half an hour.

The standard dosage includes one or two liver recovery tablets three times a day. The course of therapy, depending on the severity of the disease, is 25-30 days.

To prevent relapse of a chronic disease, a repeated course of treatment will be required at intervals of one to three months.

• Contains components of plant origin.
• Has antitoxic and hepatoprotective effects.
• Slows down the penetration of toxins into cells.
• Stimulates regeneration.
• Fast effective action.
• Affordable price.
• Relieves painful sensations.
• Can be used in combination with other drugs.

Complex preparation with herbal components. Contains fume extract, milk thistle fruit.

Has a choleretic effect. It also normalizes the amount of its production and reduces sphincter tone.

Has a hepatoprotective effect. Protects liver cells from alcohol and toxins.

Stimulates the restoration of hepatocytes and protein synthesis. Suitable for the treatment of liver diseases various stages– acute and chronic.

For maximum effect, take after meals. The standard dosage for adults is one capsule three times daily.

To remove severe pain Your doctor may prescribe an additional dose before bed. The product is produced in hard capsules.

There are thirty pieces in a package.

• Natural composition.
• Quick effect.
• Removes severe pain.
• Improves the functioning of the digestive tract.
• Relieves heaviness.
• Affordable price.
• After use, constant nausea disappears.

• Do not take if you have an individual intolerance to one of the active ingredients.
• Not prescribed for acute inflammatory processes of the liver and biliary tract.
• Should be taken with caution during pregnancy and breastfeeding.
• Inconvenient release form - large capsules.
• Laxative effect.

Refers to herbal medicines. Prescribed for gastrointestinal diseases and severe pathological conditions of the liver.

Contains flavonoid isomeric compounds. Produced in the form of dragees, capsules and suspensions.

The main active ingredient is isolated from milk thistle. The drug has hepatoprotective and antitoxic effects.

Normalizes physical and chemical parameters. Slows down the penetration of toxic components into liver cells.

Accelerates the regeneration of organ cells. Prescribed for damage by several medications - Paracetamol, antidepressants, antibiotics, after anesthesia, immunosuppressants and psychotropics.

• Relieves itchy skin and vomiting.
• Eliminates heaviness in the right hypochondrium.
• Restores appetite.
• Improves general condition.
• According to the test results, bilirubin, transaminases, and alkaline phosphatase activity decrease.
• Contains natural ingredients.

• High price.
• May cause diarrhea.
• Contains dyes.

The drugs belong to the hepatoprotectors group - herbal preparations. Silymarin is used as the main active ingredient.

It is obtained from the fruit of milk thistle. Produced by the Bulgarian company Sopharma.

The drug with the prefix “forte” has a high concentration of the active ingredient. The classic drug is produced in the form of brown dragees.

There are 80 pieces in one package. "Karsil Forte" includes 30 gelatin capsules.

Has a specific smell. Prescribed for toxic liver damage as a result of long-term treatment, for chronic and alcohol intoxication, cirrhosis, steatosis, for recovery after acute hepatitis.

• Has a stabilizing effect.
• Normalizes fat metabolism.
• Stimulates the production of phospholipids.
• Protects liver cells from the negative effects of toxins.
• Restores hepatocytes.
• Slows down fatty degeneration of the organ and the development of fibrosis.
• Has an antioxidant effect.
• Normalizes blood microcirculation.
• Improves general condition, including increasing appetite.

Liver tablets – bile acids

Ursodeoxycholic acid (UDCA) is the only one of its kind that does not harm the human body. Refers to bile acid agents. Prescribed for the treatment of diseases of the liver and biliary tract, cholelithiasis (uncomplicated type).

Do not take if the calcium content of gallstones is high. Has hypoglycemic properties. Increases gastric and pancreatic secretion. Able to change the immunological reaction of the liver. You should not take the drug without a doctor's prescription. There are very serious contraindications.

Advantages

• Reduces the number of eosinophils.
• In combination with other drugs, it will help dissolve cholesterol formations in the gallbladder.
• Will help with toxic, alcoholic liver damage.
• Can be used by pregnant women to treat hepatopathy.
• One of the most effective means for the treatment of sclerosing cholangitis (primary type) and biliary cirrhosis.
• Prescribed to the most vulnerable category of patients - in adolescence, pregnancy. And also for the treatment of hemophilia, substance abuse and drug addiction.

Flaws

• There are many drugs with unconfirmed quality.
• They can cause harm in case of inflammation of the gallbladder, intestines, dysfunction of the kidneys, pancreas, and liver.
• Individual intolerance often appears.

Rating of the best bile acid drugs for liver treatment

Rating	#1	#2	#3
Name

Hepatoprotector with cholelitic, choleretic, hypocholesterolemic, and immunomodulatory effects. Increases the protection of liver cells from bile acids.

Changes their structure. Improves the production and excretion of bile.

Destroys gallstones and protects the liver from harmful effects alcohol. Ursodeoxycholic acid in the drug prevents cholestatic liver diseases.

Produced in the form of milky gelatin capsules. The number of capsules, as well as the duration of administration, depends on the disease and body weight.

Prescribed for biliary cirrhosis at the stage of compensation of the primary type, for biliary reflux gastritis, medium and small cholesterol stones. Intended for oral use.

• Reduces cholesterol production.
• Minimizes bile lithogenicity.
• Destroys cholesterol stones.
• Replaces toxic bile acids with non-toxic ones.
• Improves the secretion of liver cells.
• Improves immunoregulatory processes in the body.
• Copes with bile stagnation.

• The drug is not prescribed to children.
• Long-term use will require significant costs.
• Causes side effects - nausea, vomiting, constipation, diarrhea.

An effective hepatoprotective drug with a choleretic effect. Reduces the concentration of cholesterol in the blood and its further absorption in the intestines.

Promotes the formation and secretion of bile. Strengthens pancreatic and gastric secretion.

Has hypoglycemic properties. When administered enterally, it partially or completely dissolves cholesterol stones.

Promotes elimination organic compound from gallstones. Has an immunomodulatory effect.

The main active ingredient is ursodeoxycholic acid. The dosage, as well as the duration of treatment, depends on the disease.

To dissolve gallstones, you will need to take Ursodez at the rate of ten milligrams of the active ingredient per kilogram of body weight. The optimal time for use is before bed.

Capsules must not be chewed. It is important to drink a small amount of water.

• Can be taken for a long time - up to 24 months.
• It is very easy to evaluate the effectiveness of the drug using ultrasound diagnostics or radiography.
• Effective treatment.
• Has a complex effect.
• Convenient release form.
• Small capsule size.
• Minimal side effects.

The hepatoprotector is produced in the form of gelatin capsules white. Packaged in plastic bottles or blisters.

Has a choleretic effect. Prevents the formation of stones.

Displays existing stones. Effectively affects the composition of bile, the functioning of the pancreas and stomach.

Activates the functions of liver cells. Increases the body's protective functions.

Absorbed into small intestine. The maximum concentration is observed in the blood two hours after administration.

Then binds to plasma proteins. As a result of prolonged use, it is converted into basic bile acid.

Located in blood serum.

• Cholesterol secretion decreases.
• Toxins are removed from the body faster.
• The functioning of the pancreas and stomach improves.
• Lipase activity increases.
• Blood sugar levels drop.
• Convenient packaging.
• It works effectively. The dynamics can be tracked based on the analysis results.
• Affordable price.

• It is forbidden to take the drug in case of calcified stones, obstruction of the bile ducts, acute inflammatory processes, hepatic colic, or if you weigh less than 34 kg.
• Causes nausea, vomiting, painful sensations, diarrhea or constipation.
• Capable of calcifying gallstones.
• Exacerbates psoriasis.
• Leads to hair loss from the scalp.

Contains ursodeoxycholic acid. Prescribed in the treatment of diseases of the digestive tract.

The main active ingredient reduces cholesterol synthesis. Due to this, the concentration in the intestines increases.

The drug has a particularly effective effect when the disease is not advanced. Doctors recommend taking the medicine in the evening.

It is enough to take the capsules with plenty of water. In the first days of taking it, you need to monitor the level of liver enzymes.

• The drug replaces harmful bile acids (with toxins) with non-toxic UDCA.
• Stimulates the body's protective functions.
• Improves the secretory properties of liver cells.
• Ursosan quickly breaks down and is eliminated from the body.
• Painlessly dissolves stones.
• Relieves the condition of gastritis.
• Wide spectrum of action.
• Safe composition.
• Eliminates colic in the right hypochondrium.
• Reduces cholesterol levels.
• Helps against jaundice in newborns.

• Not prescribed if the diameter of the stones exceeds 15 mm.
• It may not help with primary type biliary cirrhosis of the liver, even with prolonged use - from 6 to 24 months.
• There are contraindications. Do not take if you have inflammation of the gallbladder or gallstones. acute form, colic, and obstruction.
• Causes side effects.
• Prescribe with caution for hepatitis and cirrhosis of the liver.
• As a standard, the drug is allowed to be given to children from 5 years of age. But the age threshold can be changed by the doctor’s decision.
• Exceeding the dosage specified in the instructions causes distress. You need to stop the drug and consult a doctor. It is necessary to restore the water-salt balance in the body.

Has a choleretic effect. Destroys cholesterol stones.

Prevents the proliferation of connective tissue after damage to liver cells. Contains ursodeoxycholic acid.

The substance forms mixed type micelles. Protects membranes from damage.

Increases the content of bile acids. Which, in turn, promotes the dissolution of cholesterol gallstones.

Strengthens the secretion of the pancreas and stomach. It also has an immunological effect.

Adjusts the quantity immune cells. It stops fibrosis in cases of primary biliary cirrhosis, cystic fibrosis, and also in cases of alcoholic liver damage.

Reduces the likelihood varicose veins veins in the esophagus. As a result of research, the effectiveness of Ursofalk in delaying the development of tumor tissues has been proven.

Therefore, it is prescribed in combination with other drugs for the treatment of colon cancer. Produced in the form of suspension and capsules.

• There are no age restrictions.
• Reduces bilirubin. It is even prescribed to newborns.
• Can be used in combination with other drugs and herbal decoctions.
• Dissolves gallstones.
• Eliminates bending of the gallbladder.
• Has a choleretic effect.
• Eliminates allergic reaction.
• Can be used during pregnancy. Prescribed for hypatosis.
• Relieves nausea and itching.

Liver tablets of animal origin

There are only a few such drugs. They are usually not prescribed as prophylaxis. Suitable for the treatment of liver diseases for several reasons - hepatitis, cirrhosis, fatty liver hepatosis, toxic and drug-induced hepatitis. For production, depending on the preparation, pig liver cells, large liver hydrolyzate are used. cattle, cyanocobalamin, amino acids, segments of liver growth factors and low molecular weight metabolites. Pharmaceutical companies also produce drugs with combined effects.

Advantages

• Capable of restoring cell structure.
• Improve blood flow.
• Changes the functional parameters of the liver.
• After administration, diuresis usually increases.
• Can be used in combination with other drugs for the treatment of cirrhosis, chronic hepatitis, radiation sickness, fatty degeneration, and drug intoxication.

Flaws

• There is no official confirmation of the clinical safety and effectiveness of the drugs.
• Particular care should be taken when taking the medicine acute stage hepatitis A. There is a possibility of aggravation of the inflammatory, immunopathological, cytological syndrome.
• Causes a serious allergic reaction. Before starting treatment, you need to check for the presence of hypersensitivity to the components of the drug.
• Cattle liver hydrolysates can cause prion infection. The latter, in turn, causes Creutzfeldt-Jakob disease (a dangerous neurodegenerative disease).
• It is not recommended to take it as a prophylaxis.

Rating of the best drugs for the liver of animal origin

Rating	#1	#2	#3
Name

The drug contains both plant and animal components. The effectiveness of treating pathological conditions of the hepatobiliary system has been proven.

The composition includes crushed nettle leaves, garlic powder, dry bile, Activated carbon. The components regulate metabolic processes in the intestinal wall.

Suppresses the development of helminths. Vitamins of group A, D, E, K promote absorption.

Has a detoxifying effect. Stimulates the emulsification of lipids in the gastrointestinal tract.

Speeds up metabolism. Removes them from the body.

Helps reduce flatulence and the growth of pathogenic microorganisms. The duration of treatment, as well as the dosage, depends on the disease.

• Improves secretory function liver cells.
• Stimulates the synthesis of bile acids.
• Accelerates the movement of bile along the biliary tract.
• Eliminates atonic constipation.
• Prevents infection.
• Reduces inflammation.
• The film coating of the drug protects the properties of Allochol.
• Can be combined with other medications.

• There are contraindications.
• May cause side effects such as diarrhea. Also known clinical cases allergic reaction.
• Exceeding the prescribed amount of the drug leads to an overdose.
• Do not take simultaneously with Cholestyramine, aluminum hydroxide and Cholestipol.

The drug was created to protect liver tissue. It also helps restore damaged functional and structural elements of the organ.

Normalizes hepatic blood flow. Increases urination.

Improves liver function. Prescribed for chronic hepatitis, hepatocardial syndrome, liver cirrhosis, toxic hepatitis, toxicosis of pregnancy, kwashiorkor and other disorders.

There are several forms of release. Dragees are suitable for oral use.

It is also produced in the form of a solution for intravenous and intramuscular injections.

• Fast action.
• Effectively restores the liver.
• Created on a biological basis.
• Helps with viral hepatitis.
• Helps with exhaustion of the body.

The liver bioregulator improves its functions. Restores after a course of treatment, poisoning or under the influence of other negative factors.

Available in tablet form. There are 40 pieces in one package.

Prescribed for the prevention and treatment of polyetiological diseases and other liver damage. Eliminates the consequences of toxic, infectious, metabolic, involutional and other influences.

The drug relieves chronic and acute liver failure. It has hepatotropic properties.

The composition includes nucleoproteins and proteins from cattle. Strengthens reparative processes in liver cells.

Restores their work. The functional-corrective and hepatoprotective effect of the drug has been clinically confirmed.

Prescribed depending on the complexity of the disease. The standard course of treatment is from 10 to 14 days.

Repeat therapy may be required after 3 or 6 months.

• Do not take if you are hypersensitive to the drug, during pregnancy or breastfeeding.
• May cause an allergic reaction.

It has a detoxifying and hepatoprotective effect. It has an effect at two stages - in the intestines and during metabolism.

The drug is able to absorb harmful components from the intestines and restore liver cells. The composition includes essential phospholipids, amino acids, vitamins, cytochromes, trace elements, mesenchymal enzymes.

"Hepatosan" prevents the absorption of toxins and metabolic products from the large intestine. Also strengthens the walls of liver cells.

Prescribed for the treatment of liver cirrhosis, poisoning with mushrooms, alcohol or medications, chronic and acute forms of liver failure, cholelithiasis. Capsules are intended for oral use.

The dosage and duration of treatment depends on the complexity and type of disease.

• Supports the liver, pancreas, and gastrointestinal tract.
• Quick effect.
• Easy to take.
• Can be combined with other drugs, for example, Enterosan.
• Available in almost all pharmacies.

• There are side effects.
• You can take the drug during pregnancy only under the supervision of a doctor.
• Causes allergies.

The hepatoprotective drug has detoxification properties. Restores liver parenchyma, changes the synthesis of methionine and choline.

Prevents fat filtration. Contains vitamin B12.

The component ensures normal maturation of red blood cells and also promotes better hematopoiesis. It also contains amino acids, fatty acids, and carbohydrates.

Available in the form of an injection solution. Suitable for intravenous and intramuscular slow administration.

You need to mix the drug with blood or sodium chloride (0.9%). Before treatment, it is important to check the body's reaction to possible hypersensitivity.

conclusions

The liver is one of the most vulnerable organs. Suffers from poor diet, alcohol abuse and sedentary lifestyle. Various inflammatory processes can also harm the organ. There are several types of drugs for treating and restoring the organ. Before use, be sure to consult a specialist. As a rule, in such cases, appropriate diagnostics are prescribed. You can also check information about medications on pharmacy websites in the section “Medicines for the liver.”

The list of hepatoprotective drugs with proven effectiveness cannot be called extensive. Pharmacies sell more than 700 types of hepatoprotectors of various origins. The protective and therapeutic effect of most of them is confirmed only by a subjective parameter - an improvement in well-being. Only a few drugs have undergone controlled studies (suppression). Among them are products with ursodeoxycholic acid and milk thistle extract.

Indications for the use of liver protective drugs

Hepatoprotectors with proven clinical effectiveness help with various diseases liver. They are prescribed:

• against cirrhosis caused by a virus;
• against alcohol;
• for treatment (impaired flow of bile into the intestines);
• after chemotherapy, s;
• with (hepatoprotectors normalize the functioning of the biliary system);
• in the liver against the background of diabetes mellitus.

Hepatoprotectors for hepatitis C are of particular importance. They help the body get rid of infection and maintain the integrity of liver cells.

Classification of hepatoprotectors

Clinical pharmacology allows us to understand which drug can be called the most effective. Since existing hepatoprotectors for the liver only partially meet the requirements put forward by Professor R. Preisig (1970), none of them can be called ideal. Hepatoprotectors are classified into groups taking into account their origin and chemical structure.

List of essential phospholipids

The preparations are made from highly purified extract soybeans. The essential phospholipids contained in soy restore liver cells (hepatocytes), maintain their structure and participate in the transport of protein molecules through cell membranes. Today the effectiveness of the following drugs has been proven:

• Essentiale forte H. The hepatoprotector is sold in capsules or in the form of liquid for injection (prescribed in severe cases). Recommended for viral and. The drug prevents narrowing of the bile ducts. The product is contraindicated for children under 12 years of age.
• Essel forte. The drug is enriched with vitamins B and E. It is effective for various diseases digestive gland and its The hepatoprotector is available in tablets.
• Result Pro. Sold in capsules of 30, 50 and 100 pieces per package. Prescribed for toxic poisoning, cirrhosis and fatty liver.

The duration of treatment with any essential phospholipid is individual. The daily adult dose is 6 capsules.

List of hepatoprotectors from amino acids

Preparations with aminocarboxylic acids may contain:

• Ademethionine (Heptral, Heptor). The amino acid stimulates the production of phospholipids in the body, providing liver cells with a regenerating and detoxifying effect. Heptral and Heptor are administered intravenously for severe pathologies and are prescribed in tablets for moderate diseases. The drugs are considered hepatoprotectors, which help maintain the overall health of the body (improve metabolic processes, improve the quality of blood, promote the flow of bile into the intestines) in case of chronic.
• Ornithine aspartate (Hepa-merz, Larnamin) - an amino acid that helps cope with hyperammonemia (poisoning of the body with ammonia, the enzyme urea), which is a consequence of liver intoxication. Preparations containing ornithine aspartate are expensive, which is why they are rarely prescribed for preventive purposes. Release form Hepa-merz is a granulated powder for the preparation of an oral solution, Larnamin is a liquid for injection in ampoules, granulated powder in a sachet.

Therapy with animal liver extracts

Any hepatoprotector based on animal components should only be purchased with a doctor's prescription.

Not expensive drugs:

• Hepatosan - contains an extract from pig liver cells. It has a therapeutic effect on fatty hepatosis and non-infectious cirrhosis. It is taken for two weeks, 2 capsules three times a day.
• Sirepar is an analogue of Hepatosan, enriched with vitamin B12, which promotes normal hematopoiesis. Available in the form of a solution for intravenous administration.
• Progepar - contains cattle liver extract. Prescribed for any lesions of the gland, with the exception of. Sold in tablets, which are taken in 1-2 pieces. 3 times a day for 2-3 months.

Hepatoprotective drugs based on animal components increase the risk of allergies. Therefore, they are not prescribed without determining the level of sensitivity of the body to their active components.

Modern hepatoprotectors with bile acids

Manufactured using chenodeoxycholic and ursodeoxycholic acid. The first gives many side effects (nausea, biliary colic, allergies, diarrhea). Contained in the preparations Henofalk, Henosan, Henochol. They are taken to destroy cholesterol.

According to doctors, the most effective hepatoprotector is the one made using ursodeoxycholic acid:

• Ursosan;
• Ursodez;
• Ursofalk;
• Livodex;
• Ursoliv et al.

Preparations with UDCA are indicated for relieving symptoms of biliary cirrhosis, for the treatment of acute hepatitis, and drug-induced liver damage. The dosage and duration of therapy is individual. Due to the strong choleretic effect of bile acid, these drugs are not prescribed to patients with large.

Preparations of natural origin based on plants

Frequently prescribed hepatoprotectors of plant origin:

• Gepabene;
• Geparsil;
• Karsil;
• Legalon;
• Silibor;
• Silimar.

The name with the prefix “Forte” indicates that the drug has an enhanced effect.

These drugs are made using silymarin ( active substance extract). Its hepatoprotective properties help restore the liver damaged by acute or chronic hepatitis, cirrhosis. To solve the problem of gland health, it should be taken for at least three months in a row.

Hepatoprotectors of plant origin also include preparations containing artichoke extract. They are sold in tablet form and gelatin capsules:

• Hofitol;
• Holiver;
• Febichol.

The duration of use and dosage of hepatoprotectors is recommended by the attending physician, taking into account the type and severity of the disease.

Combined medications for the gallbladder and liver

List of new and known combined type hepatoprotectors (contain substances from different pharmacological groups):

• Sirin - the drug contains methionine, extracts of artichoke, milk thistle, Schisandra chinensis and other plants. The product is drunk for 30-45 days, 1-2 tablets. morning and evening after meals.
• Gepadif - a hepatoprotector is prescribed for alcohol, drug and infectious liver intoxication. Contains two amino acids (adenine, carnitine), enriched with B vitamins. Available in capsules (daily dose 4-6 pieces) and powder for infusion. Treatment may last two or more months.
• Eslidin - contains the amino acid methionine and phospholipids. Sold in capsules. Take 2 pcs. three times a day for 1-3 months in a row.
• Detoxil - made from extracts of artichoke, grapefruit, dandelion and methionine. The drug is fortified (vit. A, E, C, B). Sold in tablets. Take 1-2 pieces a month. in a day.

Combined hepatoprotectors are prescribed for prevention purposes and for diffuse changes liver.

Dietary supplements and homeopathic medicines

Hepatoprotective products and herbs

• seaweed;
• pumpkin pulp;
• low-fat fermented milk products;
• dried apricots, prunes, raisins;
• olives, olive oil;
• meat and fish of dietary grades;
• oat, millet, buckwheat cereals.

Every day you need to drink a decoction of rose hips or hawthorn, teas and infusions of hepatoprotective herbs - calendula flowers, nettle, milk thistle, artichoke.

Lifestyle

It is important for people with a diseased liver to lead an active lifestyle, but they should not subject the body to heavy stress. In a person who moves little, the processing of animal fats slows down. They are deposited in hepatocytes, which can provoke. The same thing happens to the liver of people who periodically engage in intensive sports, for example, in order to lose excess weight. For quick recovery Doctors recommend taking hour-long walks in the fresh air every day. Smokers should give up the bad habit.

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The liver is the largest gland in human body, an internal organ that is located in the human peritoneum. She is responsible for the production of bile. But this is not the only function. The liver neutralizes poisons coming from the blood, toxins, allergens, and absorbs harmful bacteria. Besides, this body participates in metabolic processes, hematopoiesis and performs many other useful functions. That is why it is necessary to select drugs for liver treatment with special attention.

Good to know

The liver has amazing properties. Few human organs are capable of actively regenerating. Patients who have had three quarters of the gland removed have every chance of having it restored to its original size.

Speaking about effective liver treatment, it should be noted that best method combating organ ailments means timely contact with medical specialists.

It is very difficult to determine the moment when problems with the gland occur. The first symptoms are mild. As a rule, people do not pay attention to the occurrence of belching. A feeling of nausea after eating or slight discomfort in the right hypochondrium are not considered sufficient reasons to visit a doctor.

The liver has no nerve endings. That's why long time may not bother its owner at all. The patient comes to the doctor with a feeling of severe heaviness in the right side. But, unfortunately, this symptomatology already indicates serious problems with iron.

But it is not all that bad. Modern medicine developed excellent livers. They are able to perfectly protect it from further destruction and help restore it.

Causes of diseases

Before considering which medications are most effective for treating the liver, you should understand what effects have a detrimental effect on this organ. Gland tissues are distinguished by their tremendous ability to recover. In addition, the liver is quite resistant to harmful environmental influences. Still, some factors can cause serious harm to her:

As you can see, diseases often arise from an incorrect lifestyle. Patients who have established healthy eating, gave up bad habits, performed liver tests, and were able to completely heal the organ.

Classification of drugs

Drugs for the treatment of the liver are divided into three subgroups:

1. Hepatoprotective drugs. They are aimed at improving metabolic processes in the organ, increasing resistance to various pathogenic influences, and accelerating the restoration of its functions after damage. This group includes many effective drugs for treating the liver. List of the most popular drugs: “Essentiale Forte”, “Karsil”, “Ovesol”, “Progepar”, “Hepatamin”, “Hepel”.
2. Choleretic drugs. Such medications increase the secretion of bile, thereby facilitating its release into the cavity duodenum. For these purposes, the drugs “Allohol” and “Cholenzim” are effectively used.
3. Cholelitholytics aimed at dissolving gallstones. These include ursodeoxycholic acid and chenodeoxycholic acid.

Let's look at the most effective and popular medications for treating the liver.

The drug "Essentiale Forte"

A complex product containing phospholipids. Improves the condition of cell membranes. It contains exclusively natural ingredients. These types of drugs are used quite effectively to treat the liver, especially in cases of autoimmune hepatitis and toxic damage.

The product perfectly improves metabolism. In addition, it helps reduce cholesterol levels. Another positive aspect of this medicine is its beneficial effect on the cardiovascular system.

The drug is well tolerated by children and adults. This product is not contraindicated for pregnant and lactating women. Often used as adjuvant therapy for radiation sickness and psoriasis. It is an excellent prophylactic for recurrent stone formation in the gallbladder.

However, the tool also has its drawbacks. If you are sensitive to any of the components of the drug, it should not be used. Sometimes adverse reactions are possible, which include diarrhea, allergies or abdominal pain.

The drug "Legalon"

The product is based on spotted milk thistle extract. Analogues are the drugs “Silibor”, “Karsil”, “Silibinin”. Due to their composition, these drugs are quite in demand for treating the liver.

The medicine has a strong hepatoprotective effect. It significantly improves digestion and intracellular metabolism. The drug is able to stabilize hepatocyte membranes. The drug is included in therapy for any liver disease. In addition, it has a rapid healing effect.

The use of this remedy improves the breakdown of lactic acid by the liver. This process helps to increase the overall endurance of the body. In addition, Legalon binds free radicals, as a result of which inflammatory processes in the organ are reduced.

Medicine "Karsil"

Considering the best drugs for treating the liver, it is impossible to ignore this wonderful remedy. It is widely used to restore gland function. It is often prescribed for prophylactic purposes to prevent pathological development changes in liver cells.

This drug is based on the fruit extract of spotted milk thistle. Indications for use are liver ailments, such as steatosis, hepatitis, cirrhosis of completely different etiologies (drug-induced, viral, toxic). The medicine is an excellent prophylactic for long-term use hepatotoxic drugs.

Children over 12 years of age are allowed. Almost always well tolerated. It is extremely rare that side effects may develop.

However, the drug also has disadvantages. Do not take this medication during pregnancy and lactation. Sometimes side effects may occur, such as nausea, diarrhea, itching, baldness, vestibular disorders.

Women should use the drug "Karsil" with extreme caution if they have ailments of the reproductive system that occur with hormonal disorders(endometriosis, fibroids, breast, ovarian or uterine carcinoma). Men who have been diagnosed with a prostate tumor should also be careful.

The drug "Heptral"

It should be remembered that only a doctor can recommend the best livers. Some patients may be prescribed this drug.

The drug exhibits hepatoprotective properties. The main active ingredient is ademetionine. This drug has detoxifying, neuroprotective, antioxidant, regenerating and antifibrosing effects.

Multiple positive properties allow it to be prescribed for:

1. Fatty liver degenerations.
2. Various toxic lesions of organs (hepatitis, alcoholic hepatosis), with drug-induced pathology that arose during long-term use of antitumor, antituberculosis, antiviral drugs.
3. Cirrhosis, fibrosis of the gland.
4. Intoxication with alcoholic beverages, narcotic substances, medicines, food.

When selecting effective drugs for treating the liver for a patient, the doctor often recommends the drug Heptral. It is not surprising, because the product has a number of advantages. For patients whose liver pathology is combined with other serious illnesses (encephalopathy, depression, joint and bone diseases), this medicine is most suitable.

However, you should be very careful with the product, as it has a large number of side effects. These may be headaches, disturbances in consciousness and sleep, allergic reactions, heart failure, nausea, diarrhea, intestinal and stomach bleeding, joint and muscle discomfort.

The drug "Gepabene"

Many effective drugs are widely used to treat liver diseases. The medicine "Gepabene" is one of them. The combined herbal remedy is based on the fruits of milk thistle and the herb fumitory. The drug has an active restorative effect. In addition, it perfectly normalizes the flow of bile.

The main advantages of this drug include:

1. The ability to stabilize the patient's condition after cholecystectomy.
2. Approved for use during pregnancy.
3. It has membrane-stabilizing and antioxidant effects in drug-induced hepatitis and long-term use of hepatotoxic medications.

The disadvantages of the drug are:

• Not used for acute diseases of the liver and biliary tract.
• Prohibited for use by patients under 18 years of age.

The drug "Galstena"

Medicines for the treatment of the liver are available in the form of drops and tablets. The drug "Galstena" is sold in two forms, it is homeopathic remedy. It is distinguished by an effective and mild hepatoprotective effect. It perfectly normalizes. The drug has anti-inflammatory, antispasmodic and choleretic effects. In addition, an effective remedy prevents stone formation in the gallbladder.

Galstena drops and tablets for liver treatment have many advantages:

1. The drug contains only herbal, natural ingredients (milk thistle, celandine, dandelion).
2. The medicine is approved for use at any age. It can even be used for newborns.
3. Effective for cholangitis, cholecystitis, pancreatitis, biliary dyskinesia, hepatitis, hepatosis.
4. It is used afterwards to improve the rehabilitation process.
5. It can be used for a long period without causing adverse reactions in the patient.

Like any drug, the product also has disadvantages:

• sometimes side effects are observed (diarrhea or increased salivation);
• The drug is not intended for people with alcohol dependence.

Medicine "Hofitol"

Combination drugs for treating the liver are effective. This is exactly what the medicine “Hofitol” is. The drug has an active hepatoprotective, choleretic and moderate diuretic effect. Helps reduce blood azotemia as a result of increased urea excretion. The medicinal effect is due to the artichoke.

The positive aspects of the drug include:

1. Possibility of use for treatment chronic cholecystitis(calculous), hepatitis, liver cirrhosis, chronic intoxication, biliary dyskinesia. In addition, it is effective for kidney pathology.
2. Used in complex therapy for obesity and atherosclerosis.
3. It has virtually no contraindications. The exception is acute diseases of the kidneys and liver, obstruction of bile ducts with stones.
4. Can be used for a long period of time.
5. Allowed (under medical supervision) during early toxicosis.
6. Does not affect reaction speed, therefore it is not contraindicated for drivers.

The disadvantages include the following:

• liver treatment tablets are not intended for children under 6 years of age;
• may cause side effects: itching, diarrhea, headache.

The drug "Rezalut Pro"

Great complex hepatoprotector. Able to stabilize membranes and regenerate liver cells. In addition, it normalizes lipid metabolism and reduces cholesterol levels.

The drug is used for:

• hepatitis;
• hepatosis;
• cirrhosis;
• toxic organ damage;
• fatty gland degeneration;
• atherosclerosis;
• hyperlipidemia;
• ailments of blood vessels and heart;
• psoriasis, eczema, neurodermatitis.

In case of antiphospholipid syndrome, this drug is contraindicated. It is not intended for children under 12 years of age. The product should be used very carefully by pregnant and lactating women.

Conclusion

The human body is designed in such a way that all organs can be classified into auxiliary and vital. Undoubtedly, the liver belongs to the second group. Its importance for the vitality of the body is great. It is not surprising that any disruptions in its functioning affect many human systems.

Such a powerful organ combined the functions of the digestive gland and a kind of biochemical laboratory. After all, it is in the liver that all reactions that are responsible for supporting life processes occur. But, unfortunately, this organ is vulnerable. Even despite excellent regenerative abilities, the number of patients with glandular diseases is steadily growing. That is why it is important to start the fight against pathologies in a timely manner and very carefully select effective drugs for treating the liver.

Treatment of liver pathology is not complete without the prescription of medications that ensure restoration of damaged hepatocytes, protection of viable cells, and activation of lost functions.

Hepatoprotectors for the liver do not replace medications. The list of drugs for liver therapy includes antibacterial, antivirals, hormones, complex vitamins, immunomodulators, homeopathic medicines.

It is difficult to determine the best of more than 200 drugs. We will be based only on verified facts from the evidence-based medicine database. It includes only those medications that have been tested on a sufficient number of cases and have reliable results of effectiveness compared to a group of patients to whom they were not prescribed.

Who are hepatoprotectors indicated for?

Some people think that hepatoprotectors are only necessary for various diseases that involve cell damage, but this is not so. Most effective action they have as a means of prevention.

Conditions for the need to support and protect liver cells arise:

• in case of violation of the usual regime and quality of nutrition in holidays when it is impossible to avoid overeating tasty but difficult-to-digest food or drinking alcohol;
• after acute infectious diseases and their treatment (ARVI, influenza, intestinal infections, food poisoning);
• if you moved to another area where the ecology and quality of drinking water have changed.

People over 60 years of age especially need to “cover” their liver. This is due to impaired adaptability of the body and low general immunity.

Hepatoprotective drugs are necessarily included in the treatment regimen for acute and chronic diseases liver:

• for inflammation (hepatitis) viral origin, toxic, alcoholic, nutritional;
• hepatoses caused by altered metabolic processes (fat, cholestatic, pigment) that occur when diabetes mellitus, alcoholic hepatitis, impaired bile secretion, enzymatic hereditary pathologies of bilirubin metabolism;
• at the stage of initial cirrhotic or fibrotic changes in the liver tissue;
• patients with liver damage caused by forced long-term use of medications for systemic lupus erythematosus, ankylosing spondylitis, Wilson-Konovalov's disease, and tuberculosis;
• in case of development of cardiac cirrhosis due to decompensation of myocardial function.

Classification

There is no uniform classification of drugs from the list of hepatoprotectors. It is customary to divide them by origin and basic basis. The mechanism of action is often the same. IN pharmacological group includes products made from plant materials, animal liver, artificially synthesized, combined with multivitamins.

In form they are represented by tablets, capsules, injection ampoules, drops

Depending on their origin, there are 6 groups of hepatoprotectors:

• essential phospholipids;
• preparations from animal liver tissue;
• amino acid derivatives;
• medicinal protectors from bile acids;
• herbal remedies(herbal infusions, extracts of medicinal plants);
• biologically active food additives (BAS) and homeopathic medicines.

Hepatoprotectors are used as treatment agents in Russia and the CIS countries. Doctors in Europe and the USA do not consider them medicines due to insufficient evidence base on effectiveness. The situation even develops in such a way that the country produces the drug, but sends it not to its pharmacy network, but to Russia and the CIS (like the French company Sanofi Essentiale).

The attending physician decides which medications are best to use in a particular case. It is not recommended to choose medications on your own. They have their own characteristics and optimal options for action. Negative influence cannot be completely ruled out. We will look at examples of the most popular drugs, indications for their use, and give opposing opinions for and against.

Essential phospholipids

There is no consensus among researchers about the mechanism of action of the drugs.

"Behind"

In accordance with the Instructions, we are asked to believe that essential phospholipids obtained from soy are the same in composition as the components of the cell membrane of hepatocytes. Getting into the fatty layer of the wall of a damaged hepatocyte, they are able to restore cell functions and improve their functions.

It has been proven that in patients taking phospholipids: energy expenditure by liver cells decreases, enzyme activity increases, the properties of produced bile improve, and when treating hepatitis C, the likelihood of an active response of the body to the administration of α-interferon increases. They work most effectively in injections.

To get results, you need to take medications of this type for six months or longer; they are not recognized by doctors in most countries.

"Against"

Studies have been published refuting the effect of phospholipids on liver function. The negative effect is to provoke inflammation in chronic forms of hepatitis, which is associated with the lack of choleretic properties and stagnation of bile.

There is an opinion that the vitamins present in the composition cannot be taken at the same time; it is better to replace them with separate preparations. Some authors are confident that the composition of the tablets reaches the liver in a very small dosage, since it is distributed throughout the body.

These “disadvantages” require a careful attitude towards essential phospholipids in viral hepatitis, taking into account the compatibility of vitamins.

Main drugs of the group:

• Essentiale N, Essentiale Forte N - contains only phospholipids;
• Essliver Forte - includes phospholipids + vitamins B, E, PP;
• Phosphonciale - the active ingredient silymarin in combination with lipoid C;
• Gepagard - phospholipids + vitamin E;
• Phosphogliv - phospholipids in combination with trisodium salt of glycyrrhizic acid;
• Rezalut - phospholipids + triglycerides + glycerol + soybean oil + vitamin E.

The most expensive are Essentiale Forte N and Rezalut. In the Russian Federation, they are prescribed for fatty hepatosis, toxic hepatitis, toxicosis in pregnant women, before an upcoming operation on the biliary tract, cirrhosis of the liver, and metabolic disorders.

Animal liver products

Based on their origin, there are two types of drugs: Hepatosan - from pork liver, Sirepar - from liver tissue of cattle. They contain cyanocobalamin, growth factor, amino acids in combination with low molecular weight metabolites.

Due to the significant number of negative effects, medications are not used for the purpose of prevention, only for treatment. Prescribed for liver cirrhosis, fatty hepatosis, hepatitis, hepatomegaly.

Call increased sensitivity in many patients

"Behind"

The instructions indicate pronounced antioxidant properties, the possibility of eliminating intoxication and stimulating the healing of parenchymal liver tissue. Progepar, part of the group, activates blood flow in the affected organ, blocks the formation of connective tissue (cirrhosis), accelerates the elimination of toxins through diuresis, and therefore improves all liver functions.

"Against"

The effect of this group of hepatoprotectors on the liver and the body as a whole is the most controversial. Moreover, the safety of the proposed drugs has not been proven. The ability of drugs to cause an allergic reaction is very high. Therefore, use in the acute phase of hepatitis is considered dangerous.

There is an opinion that pharmaceutical production does not exclude the danger of infection with prion infection (small protein substrates similar in effect to viruses) with the development of incurable encephalopathy. The drugs in this group also include the dietary supplement Hepatomin. The products are strictly contraindicated for children.

Hepatoprotectors from amino acids

Depending on the protein composition, products with:

• ademetionine (representatives Heptor and Heptral);
• ornithoaspartate (Hepa-merz).

"Behind"

We know that amino acids are necessary for the body to synthesize all active substances, enzymes, including phospholipids. Through the formed compounds, they participate in the processes of regeneration of liver tissue and relieve intoxication.

Heptral - has the ability to break down and remove accumulated fats, cleanses the liver, and has antidepressant properties. Prescribed in therapy fatty liver disease, hepatitis, withdrawal syndrome and depression in alcoholism and drug addiction.

Ademetionine derivatives have an antioxidant effect, stimulate the production of bile and its secretion, protect the nervous system and liver parenchyma from fibrosis. Hepa-merz is effective for removing ammonia compounds from the blood, so the only indication is toxic hepatitis with renal failure and hepatic coma.

The drug is effective when used intravenously; it is believed that use in tablets is limited by low absorption in the digestive tract

"Against"

Heptral, unlike other protectors, is registered, in addition to Russia, in Germany and Italy. Australians use it in veterinary practice. In other countries, it is listed as a dietary supplement with questionable properties. Hepa-Merz does not produce results in cases of alcohol intoxication.

Bile acid medicines

The base substance of this group of protectors is ursodeoxycholic acid. Drugs (Ursosan, Ursofalk, Urdoxa, Exchol, Livodexa, Ursodez, Choludexan, Urosliv) are widely used in the treatment of diseases of the gallbladder and biliary tract, cholelithiasis.

They have a choleretic and hypoglycemic effect, reduce cholesterol concentrations, and are effective in stagnation, have a stimulating effect on the immune system. These medications are indicated for biliary cirrhosis of the liver, biliary reflux gastritis, acute hepatitis in pregnant women, and the toxic effects of alcohol and drugs.

The drug can reduce blood glucose levels

Contraindications include: large calcium stones in the bile ducts, acute intestinal inflammation, severe pancreatic dysfunction. Drugs in this group are the most harmless to the human body. They are taken in courses depending on the patient’s condition.

Herbal preparations

The group of hepatoprotectors represents an improved traditional treatment liver diseases, since the drugs are synthesized from well-known medicinal plants (milk thistle, artichoke, immortelle, bearberry, oats, mint). Their effect occurs slowly and long courses of treatment are required.

But they remain optimal choice For prophylactic intake. Milk thistle preparations contain the active substance silymarin (Legalon, Karsil Forte, Karsil, Silymarin, Silibinin, Silimar). Oil, milk thistle capsules, and meal are actively recommended.

It is known to have a strong antioxidant effect and regeneration of cell membranes. The course of treatment lasts for 3 months. Negative information includes clinically unproven treatment viral hepatitis and alcoholic liver damage, which classifies the drugs in many countries as dietary supplements.

Artichoke preparations contain the active substance cymarin. It is known for its anti-inflammatory properties (for joint pain), lowering cholesterol levels, and diuretic effect. Representatives of the group - Hofitol, Cynarix, artichoke extract,

“Against” use - absence clinical trials, showing the results of treatment, contraindications for congestion in the biliary system, calculous process.

The drug has low toxicity and is used in recovery from binge drinking and in the treatment of atherosclerosis and cholecystitis.

Dietary supplements and homeopathic medicines

Sufficiently researched drugs with proven effectiveness include:

• Galstena - contains active components of milk thistle plants, dandelion root, May celandine in combination with phosphorus and sodium sulfate. Prescribed by homeopaths in drops according to the scheme for the treatment of liver diseases, both acute and chronic stage, with cholecystitis, pancreatitis.
• Hepel - includes the healing properties of milk thistle, cinchona, nutmeg, celandine in combination with phosphorus and colocynth. It has anti-inflammatory, analgesic, choleretic and antidiarrheal properties. Recommended for toxic and inflammatory liver diseases, flatulence, loss of appetite, acne.

The drugs are used for prevention. Official medicine homeopathic medicines are not recognized.

Of the dietary supplements, Liv 52 is most often used. Manufacturers promise an effect due to the total choleretic, restorative effect and moderate antioxidant effect. The drug is recommended for the treatment of children with hepatitis A, as a prophylactic agent.

Foreign studies have confirmed only a decrease in bilirubin in the blood and restoration of body weight. No effect was observed in alcoholic hepatitis. Some dietary supplements have passed clinical trials and have been successfully recommended for practical use. These include Hepatotransit, Milona 10, Gepatrin, Dipana, Ovesol.

The medicine contains extracts of seven plants

Is it possible to protect the liver from alcohol using hepatoprotectors?

There are adults who are sure that after taking “liver pills” they can drink alcohol-containing drinks in any quantity and not be afraid of cirrhosis. This is absolutely not true. Despite their name, hepatoprotectors act very slowly until the negative impact is completely removed.

They are not suitable for quick sobering up and do not guarantee the prevention of liver disease in alcoholism. It has been proven that in initial stage cirrhosis, when only part of the hepatocytes is damaged, it is possible to completely restore liver function if you give up alcohol.

For this, in addition to suitable hepatoprotectors, use:

• a strict diet with restrictions on fatty, fried, smoked foods, and spicy seasonings;
• choleretic drugs;
• pancreatic enzymes (it suffers from alcohol no less than the liver);
• herbal teas;
• drugs to improve kidney function.

You will have to see a doctor and tell about the problem. The prescribed examination and results will show the degree of dysfunction of the liver and other organs. You cannot choose medications on your own; they may be contraindicated in a particular case.

For those people who are engaged in “cleaning” the liver with various drugs, it is advisable to take into account that products made from amino acids, ursodeoxycholic acid, and silymarin have proven effectiveness.

For essential phospholipids in pharmacology, the mild formulation “presumed effectiveness” is used. The action has been proven with intravenous administration. It is better not to spend the family budget on other hepatoprotectors.