Instructions for No-shpe. Everything about taking medication
The basis of this drug is drotaverine, an active substance that helps to effectively relieve spasms and relax smooth muscles. various organs. IN Russian pharmacies No-shpu can be found in the form of tablets and ampoules. As a rule, these are French-made products.
The description of the medicine states that it is intended to relieve pain in the following cases:
- ailments of the biliary tract (cholecystolithiasis, cholecystitis, etc.);
- pathologies of the urinary system (cystitis, nephrolithiasis, etc.);
- in the form of ampoules - also to reduce the phase of cervical dilation and shorten the duration of labor.
No-shpu is used as an additional medicine:
- to relieve spasms in the gastrointestinal tract (ulcers, gastritis, colitis, enteritis, etc.);
- for the purpose of treating a headache that a person characterizes as “a hoop or belt around the head”;
- with dysmenorrhea - painful sensations during ;
- if we are talking about injections, they are also administered during strong contractions during childbirth.
One tablet or 2 ml ampoule contains 40 mg of drotaverine. Recommended dosages of No-shpa:
- Single dose for adults – no more than 2 tablets. You can take a maximum of 6 tablets per day in 3 doses.
- The maximum dose for a child from 6 to 12 years old is 2 tablets per day, but not more than 1 piece. for 1 appointment.
- Children over 12 years of age are allowed to take no more than 4 tablets, divided into 2-4 times, within 24 hours.
- In the form of injections for adults - up to 240 mg per day, but not once, but in 2-3 doses.
Attention! There is also No-shpa Forte, which contains 2 times more drotaverine - 80 mg in 1 tablet. Accordingly, the manufacturer has provided other dosages for it.
Some instructions indicate that the medicine should not be taken by a child under 6 years of age, others - up to 1 year. In practice, doctors sometimes prescribe the drug to children, allowing them to drink half, 1/3 or 1/4 of the tablet at a time. And if about childhood There are disagreements among pharmacists, then it is absolutely impossible for people suffering from kidney, liver or heart failure to be treated with No-shpa. The drug is not prescribed to those who are lactose intolerant (it is available in tablets), as well as.
If the product is not suitable for you, this will become clear from the side effects:
- decreased blood pressure (therefore, in case of hypotension, No-shpa should be taken with caution);
- headache, dizziness;
- constipation, nausea, vomiting;
- allergic reactions and etc.
If you take No-shpa on your own for 1-2 days, but do not feel any improvement, consult a doctor. If we are talking about using the drug as complementary therapy, you can delay your visit to the hospital for up to 3 days.
Attention! Unlike tablets, the injection solution is sold only by prescription.
How to replace no-shpu. Reviews about the medicine and its analogues
No-shpu can be purchased in packages of 6, 20, 24, 60 or 100 tablets, in liquid form - in boxes containing 5 or 25 ampoules. When expressing their opinion about this drug, users emphasize:
- The medicine relieves spasms well in both adults and children (as prescribed by a pediatrician). There are many positive reviews from those who suffer from stomach pain;
- No-spa, in comparison with analogues, is more gentle;
- helps maintain pregnancy if the cause of the threat is uterine hypertonicity;
- useful before going through some painful procedures– for example, colonoscopy;
- but taking it can be harmful for prostate adenoma.
The cost of 24 tablets of No-shpa is approximately 190 rubles, the larger the pack, the more profitable it is, of course, in terms of price. However, you can buy cheaper analogues of the drug in pharmacies:
- Drotaverine. The most popular substitute for No-shpa. Available in the same dosage: 1 tablet - 40 mg of active ingredient. The cost of a package with 20 pcs. – from about 12 rub. There is also Drotaverine Forte. According to reviews, this drug is absolutely comparable to No-shpa, but has nice bonus in the form of a low price. Therefore, many users note that they are switching to cheap analogue.
- Spasmol. The composition is the same as No-shpa and Drotaverine. According to reviews, it replaces both medications well. Although there are opinions that Spasmol is more of an analogue of papaverine, and can also be harmful during menstruation. The average cost is about 30 rubles. for 20 tablets. True, in Lately The drug can be difficult to find in pharmacies.
- Spasmonet. Price for 20 tablets – about 70 rubles. Considering that there are cheaper antispasmodics with drotaverine, this medicine may not be the most popular. However, those who have taken it note its high effectiveness for various painful sensations.
It is worth remembering that everything medicines have contraindications and side effects. There is also such a factor as individual intolerance. Therefore, if drugs with drotaverine are not suitable for you, look for another antispasmodic, remembering to consult with your therapist.
No-shpa and its analogues: video
Antispasmodic drugs are widely used to dilate blood vessels and relieve spasms of the smooth muscles of organs. Which is better - Drotaverine or No-shpa? This question interests many patients who want to know why doctors often prescribe. The action of both drugs is aimed at eliminating spasms and pain. Moreover, both medications have the same dosage of active medicinal substance drotaverine. But these medications also have some differences that every person needs to know.
Drotaverine and Nosh-pa - comparative characteristics
Antispasmodics eliminate spasms of various types internal organs and help quickly relieve pain. Abdominal pain may be caused by pathological process– inflammation in the biliary tract, cystitis, gastrointestinal tract infection.
Spasms cause irritable bowel syndrome, enteritis, ulcers, cholecystitis. For many pregnant women, doctors prescribe antispasmodics to restore uterine tone and prevent miscarriage. A table that clearly shows the characteristics of both medications will help you understand the features of both drugs.
| Options | Drotaverine | No-shpa |
| Medication group |
Antispasmodics |
|
| Form of production |
Capsules, injection solutions. |
|
| Main effective substances in the composition | Drotaverine (40 mg), lactose, povidone, crospovidone | Drotaverine (40 mg), lactose, povidone, starch |
| Indications for use | - vascular spasms, - pyelitis, Intestinal colic, Stomach ulcer, Cholecystitis, cholelithiasis, Gastritis, Gallbladder diseases, Cholelithiasis, Menstrual pain Spastic colitis. |
- pain relief and relief of spasms, - colitis, Diseases of the stomach and gastrointestinal tract, Headache, Gastritis, Bladder diseases, Urolithiasis disease, Papillitis, Colic in the liver and stomach. |
| Contraindications |
|
|
| Side effects due to errors in use and dosage | - disorders digestive disorders chair, Dizziness, Headache, Insomnia, Allergy. |
- stool disorders, - disorders of the digestive organs, Headache, dizziness, vision disorders, Allergic rash. |
| Safety for the whole body | Safely | Safely |
| Prevention of liver diseases |
As prescribed by a doctor |
|
| Course of therapy | ||
| An analogue of the drug, with a stronger effect. | Bioshpu, Ple-Spa, Nosh-bra, Nikoverin, Spazoverin, Spasmonet, Spasmol | Nosh-bra, Spasmol, Spazoverin, Vero-Drotaverin |
| Manufacturer | Russia | Hungary |
| Average price | Tablets 80 mg 20 pieces - 60 rubles, for 10 ampoules of 2 ml - 58 rubles | Tablets 40 mg 6 pieces - 69 rubles, for ampoules of 2 ml - 90 - 160 rubles |
Antispasmodic drugs are prescribed to eliminate spasms of smooth muscles. During pregnancy, it is prescribed to relieve pain and when there is a threat of miscarriage, but only in special cases to remove high risks. Drotaverine is also indicated for severe cough to relieve spasms, headaches and menstrual pain. During bronchospasm, the medicine helps relieve a painful attack and restore breathing.
Good to know
Drotaverine is used to relieve pain and spasms. He does not participate in the process of eliminating the cause of the disease. In some cases, doctors recommend taking Drotaverine or Noshpa to calm you down before bed. The drug can be used in extreme heat. Which is better – Drotaverine or Noshpa? Doctors prefer to prescribe the imported drug Noshpa, based on its safer effects.
Differences between the two drugs
In terms of their effects and properties, both drugs are almost identical. Despite similar pharmacological properties, the drugs have the following differences:
- Manufacturer. No-shpa is produced by a well-known Hungarian company, while Drotaverin is a Russian analogue.
- Drotaverine contains crospovidone.
- Large doses of Drotaverine can cause disturbances in cardiac activity and even cardiac arrest. Noshpa is safer to use.
- Drotaverine can be taken by children from 3 years of age. Noshpa is recommended for use from 5-6 years.
- Drotaverine is cheaper than the imported drug Noshpa.
Important! The use of the substance drotaverine can be dangerous at low blood pressure and hypotension. Both drugs lower blood pressure and have a vasodilatory effect. Drotaverine can be taken during hypertensive crisis to lower blood pressure. Injections of Noshpa and Drotaverine are prescribed in extreme cases when swallowing the tablet is impossible for some reason.
Common features of the two drugs
What better than Drotaverine or Noshpa? Drotaverine is an analogue of the more expensive imported medicine No-shpy. Both products contain the same amount of active drug. The drugs are almost identical in their pharmacological properties. Their action is aimed at eliminating spasms and pain. Medicines do not interfere with the functions of the central nervous system, relax smooth muscles and soothe. Intravenous or intramuscular injections may impair the patient's psychomotor function.
No-spa is the most famous antispasmodic, the effectiveness of which is highly appreciated by doctors and patients. However, despite everything positive traits, in some cases it is impossible to take it, and therefore there is a need to look for other drugs. Replacing No-shpa with analogues is not difficult, since there is a large selection on the modern pharmaceutical market various means similar in composition or action.
: a brief description of
The antispasmodic effect of the drug is provided by the active component drotaverine. The substance has a powerful inhibitory effect on smooth muscles, since it selectively inhibits the activity of the enzyme phosphodiesterase type 4 without affecting its other types. As a result, a chain reaction is started, which results in relaxation of the smooth muscles of various organs.
The substance relieves spasms of a neurogenic and muscular nature in the gastrointestinal tract, genitourinary system and railway tracks. In addition, drotaverine has the ability to constrict blood vessels, due to which, after taking it, the supply of blood to tissues is activated. The totality of all processes triggered by the drug, pain relief is achieved by eliminating spasms.
Drotaverine and its derivatives do not pass through GERD; in small quantities they overcome placental protection. It is completely eliminated from the body 3 days after the first dose.
No-spa is used for:
- Spasms of smooth muscles in pathologies of bile and urinary tract
- IN complex therapy to relieve gastrointestinal spasms (for peptic ulcer/duodenum, gastritis, irritable bowel syndrome with accompanying bloating, colitis and spastic colitis with constipation, etc.)
- Relieving tension headaches
- Painful menstruation.
The antispasmodic is available in tablets and injection solution.
Contraindications:
- Individual hypersensitivity to the components of the drug
- Severe forms of liver, kidney, heart failure
- Age under 6 years
- Lactation (due to unproven safety)
- Congenital galactose intolerance, lactase deficiency, GG malabsorption.
Additionally for the solution:
- Childhood
- Hypersensitivity to sodium disulfite.
Caution is required when treating patients with hypotension (due to high risk collapse) and pregnant women.
Side effects after taking No-shpa manifest themselves in disruption of the functioning of some internal systems
- NS: headaches, insomnia, dizziness
- CVS: increased heart rate, decreased blood pressure
- Gastrointestinal tract: nausea, constipation
- Manifestation of allergies: skin irritation, Quincke's edema, urticaria.
An overdose is manifested by severe cardiac disorders, including cardiac arrest. If intoxication with an antispasmodic is suspected, it is necessary to take urgent measures: cleansing the body of the drug, maintaining the cardiovascular system.
No-shpa substitutes
Instead of No-shpa, another antispasmodic drug should be used after medical consultation.
The drug is produced by many Russian pharmaceutical companies. Like No-shpa, the substitute is presented in the form of tablets and injection solution.
There are minor differences only in the composition of the excipients.
A significant advantage of the domestic product is that the drug costs much less than the original antispasmodic.
Other drugs with drotaverine: Doverin, Droverin, Spasmol, Spasmonet, Spazoverin, Spakovit,
The multicomponent product differs from No-shpa in more wide range actions. The drug anesthetizes, suppresses inflammatory processes, lowers the temperature. Produced in tablets containing several active ingredients: drotaverine, paracetamol, caffeine, naproxen, pheniramine maleate.
Indicated for use:
- To eliminate pain of various origins and localization (including muscle, menstrual, dental, neuralgic, headache, etc.)
- When neutralizing pain syndrome provoked by spasms of smooth muscles of various organs (cholesterolitis, cholecystitis, renal colic etc.)
- To suppress pain after injury and surgical operations which may be accompanied by inflammatory processes
- For the treatment of colds with accompanying fever.
Contraindications:
- Individual supersensitivity of the body to the substances contained
- Exacerbation of ulcerative-erosive diseases of the gastrointestinal tract
- Bleeding from the digestive organs
- Intolerance to ASA and its derivatives
- Severe forms of liver and/or kidney failure
- Spinal cord dysfunctions
- The period after AC bypass surgery
- Severe hypertension
- Severe pathologies of the cardiovascular system
- Frequent ventricular extrasystole
- High blood potassium levels
- Paroxysmal tachycardia
- Pregnancy, GW
- Children's and adolescence(up to 18 years old).
Taking the drug usually does not cause negative reaction body, but in some people it can cause dysfunction of internal systems or organs:
- Allergic reactions, Quincke's edema
- Hematopoietic disorders
- Increased anxiety, tremors, dizziness, absent-mindedness
- Increased blood pressure, arrhythmia, rapid heartbeat
- Abdominal pain, erosive and ulcerative damage to the gastrointestinal tract, nausea, liver dysfunction
- Kidney dysfunction
- Hearing deterioration, increased VG pressure in patients with glaucoma, ringing in the ears.
Russian antispasmodic based on papaverine hydrochloride. Produced in tablets, solution for injections, suppositories.
The active component also suppresses the activity of PDE, reduces the level of calcium concentration in cells, resulting in relaxation of smooth muscles. It has a vasodilating and hypotensive effect.
In moderate dosages, it has almost no effect on the central nervous system; in high doses, it reduces myocardial excitability and slows down AV conduction. In the body it overcomes internal barriers. It is removed from the blood within 24 hours after the first dose.
- To relieve spasms of smooth muscles of the gastrointestinal tract, bronchi, blood vessels of the brain and limbs, kidneys
- Angina therapy
- When preparing patients for surgical and diagnostic procedures.
Possible side effects:
- Nausea
- Difficulty defecating
- Drowsiness
- Increased sweating
- Hypotension
- Liver enzyme activity
- With rapid administration: AV block, heart rhythm disorders.
Contraindications:
- Supersensitivity to components
- AV block
- Glaucoma
- Severe liver dysfunction
- Infant (up to 6 months) and elderly (after 65 years) age.
When using Papaverine instead of No-shpa, you need to take into account that the replacement has a weaker effect than the first drug.
Any analogues of No-shpa, cheap or expensive, should be used after consultation with the attending physician. With this approach, you can protect yourself from severe side effects and thereby avoid complications.
The basis of this drug is drotaverine, an active substance that helps to effectively relieve spasms and relax the smooth muscles of various organs. In Russian pharmacies, No-shpu can be found in the form of tablets and ampoules. As a rule, these are French-made products.
The description of the medicine states that it is intended to relieve pain in the following cases:
- ailments of the biliary tract (cholecystolithiasis, cholecystitis, etc.);
- pathologies of the urinary system (cystitis, nephrolithiasis, etc.);
- in the form of ampoules - also to reduce the phase of cervical dilation and shorten the duration of labor.
No-shpu is used as an additional medicine:
- to relieve spasms in the gastrointestinal tract (ulcers, gastritis, colitis, enteritis, etc.);
- for the purpose of treating a headache that a person characterizes as “a hoop or belt around the head”;
- with dysmenorrhea - painful sensations during menstruation;
- if we are talking about injections, they are also administered during strong contractions during childbirth.
One tablet or 2 ml ampoule contains 40 mg of drotaverine. Recommended dosages of No-shpa:
- Single dose for adults – no more than 2 tablets. You can take a maximum of 6 tablets per day in 3 doses.
- The maximum dose for a child from 6 to 12 years old is 2 tablets per day, but not more than 1 piece. for 1 appointment.
- Children over 12 years of age are allowed to take no more than 4 tablets, divided into 2-4 times, within 24 hours.
- In the form of injections for adults - up to 240 mg per day, but not once, but in 2-3 doses.
Attention! There is also No-shpa Forte, which contains 2 times more drotaverine - 80 mg in 1 tablet. Accordingly, the manufacturer has provided other dosages for it.
Some instructions indicate that the medicine should not be taken by a child under 6 years of age, others - up to 1 year. In practice, doctors sometimes prescribe the drug to children, allowing them to drink half, 1/3 or 1/4 of the tablet at a time. And if pharmacists have disagreements about childhood, then it is absolutely impossible for people suffering from kidney, liver or heart failure to be treated with No-shpa. The drug is not prescribed to those who are lactose intolerant (it is available in tablets), as well as to nursing mothers.
If the product is not suitable for you, this will become clear from the side effects:
- decreased blood pressure (therefore, in case of hypotension, No-shpa should be taken with caution);
- headache, dizziness;
- constipation, nausea, vomiting;
- allergic reactions, etc.
If you take No-shpa on your own for 1-2 days, but do not feel any improvement, consult a doctor. If we are talking about using the drug as an additional therapy, you can delay your visit to the hospital for up to 3 days.
How to replace no-shpu. Reviews about the medicine and its analogues
No-shpu can be purchased in packages of 6, 20, 24, 60 or 100 tablets, in liquid form - in boxes containing 5 or 25 ampoules. When expressing their opinion about this drug, users emphasize:
- The medicine relieves spasms well in both adults and children (as prescribed by a pediatrician). There are many positive reviews from those who suffer from stomach pain;
- No-spa, in comparison with analogues, is more gentle;
- helps maintain pregnancy if the cause of the threat is uterine hypertonicity;
- useful before undergoing certain painful procedures, such as colonoscopy;
- but taking it can be harmful for prostate adenoma.
The cost of 24 tablets of No-shpa is approximately 190 rubles, the larger the pack, the more profitable it is, of course, in terms of price. However, you can buy cheaper analogues of the drug in pharmacies:
- Drotaverine. The most popular substitute for No-shpa. Available in the same dosage: 1 tablet contains 40 mg of active ingredient. The cost of a package with 20 pcs. – from about 12 rub. There is also Drotaverine Forte. According to reviews, this drug is absolutely comparable to No-shpa, but has a pleasant bonus in the form of a low price. Therefore, many users note that they are switching to a cheaper analogue.
- Spasmol. The composition is the same as No-shpa and Drotaverine. According to reviews, it replaces both medications well. Although there are opinions that Spasmol is more of an analogue of papaverine, and can also be harmful during menstruation. The average cost is about 30 rubles. for 20 tablets. However, recently the drug can be difficult to find in pharmacies.
- Spasmonet. Price for 20 tablets – about 70 rubles. Considering that there are cheaper antispasmodics with drotaverine, this medicine may not be the most popular. However, those who have taken it note its high effectiveness for various painful sensations.
It is worth remembering that all medications have contraindications and side effects. There is also such a factor as individual intolerance. Therefore, if drugs with drotaverine are not suitable for you, look for another antispasmodic, remembering to consult with your therapist.
Characteristics of the original drug
The drug "No-Shpa" is available in two forms: solution for injection and tablets. The latter type is more popular. The medicine is an over-the-counter drug and is available in almost every pharmacy chain. It produces an antispasmodic effect without affecting the functioning of the nervous system.
the drug “No-Shpa” is indicated, analogues of which have similar indications, for spasms of smooth muscles of different localization (digestive tract, urinary tract, reproductive organs, vessels). The use of the medication is contraindicated in case of renal and heart failure, children in the first year of life and persons with hypersensitivity To active substance, which is drotaverine hydrochloride. The cost of ten No-Shpa tablets is about 150 rubles.
Analogue of the drug "No-Shpa"
You should change the medicine if you have contraindications to its use. Patients with adverse reactions the medicine is changed to an alternative one, but with a different composition. Tablets and solution "No-Shpa" have structural and relative analogues. The latter include any painkillers: “Ibuprofen”, “Paracetamol”, “Analgin”, “Nimesil”, “Ketorol”. Such medications should be chosen together with your doctor. Closer in action will be “Papaverine” and “Papazol”.
Absolute structural substitutes for the drug “No-Shpa” include the following analogues: “Drotaverine”, “Spazmonet”, “Spazmol”, “NOSH-BRA”, “Spazoverine” and so on. Let's look at some of them and find out if there is a significant difference between the drugs.
Inexpensive product "Drotaverine"
This drug contains the same active ingredient as the expensive foreign medicine. Tablets and injections "No-Shpa" have a Russian analogue - "Drotaverin". Its cost is approximately 30 rubles for 20 pills. This is much cheaper than the originally announced medicine. According to the instructions for use, “Drotaverine” is prescribed to women in labor during labor to relieve cervical spasms. The drug is used for flatulence. It has much more indications for use than No-Shpa tablets and injections. Analogue with trade name"Drotaverine" is not used for children under 12 years of age. This is an important difference from an expensive substitute.
Little-known "Spazmol"
The next substitute for the drug “No-Shpa” (analogue) is the Russian “Spazmol”. The composition still contains the same drotaverine. Indications for use: treatment and prevention of smooth muscle spasms, cervical spasm during childbirth, painful menstruation, spasms of cerebral vessels. You should not take this medicine in the same situations as the No-Shpa drug. Some sources indicate that this medication is prohibited for use by pregnant and lactating women. But these data are called into question.
"Spasmonet" will eliminate pain
Another analogue of the drug “No-Shpa” with the same active ingredient is “Spazmonet” tablets. Their name speaks for itself. The medicine is used for spasms of smooth muscles of the digestive tract, constipation, stomach ulcers, arterial spasms, and uterine hypertonicity during pregnancy. The manufacturer names low blood pressure and hyperplasia as additional contraindications to treatment. prostate gland. Children under 6 years of age should not use the drug without medical advice.
What kind of feedback can you hear?
Of all the medicines presented, No-Shpa is the most popular. This medication is prescribed to expectant mothers without much fear. The use of "Drotaverine" among expectant mothers is also practiced. Clinical studies have shown the safety and effectiveness of these medications. While the effect of other analogues is questioned. Consumer reviews of medications vary. Some people praise the drugs, while others criticize them. Everything here is very individual. If pain syndrome is caused by a spasm, then any of the listed remedies will help you. If discomfort is caused by other reasons, all drugs may be powerless.
Buyers are often indignant because of the high cost of No-Shpa tablets. They prefer to choose cheaper analogues. If in alternative means contains the same active ingredient as the prescribed medicine, then you may well give it preference. Mandatory medical consultation is required in situations where No-Shpa is replaced in pregnant and lactating women, persons with chronic diseases and small children.
Conclusion
The article introduced you to the well-known myotropic antispasmodic called “No-Shpa”. Instructions for use, price, analogues of tablets are described for you. Many consumers are trying to find a cheap substitute for an expensive drug. It is worth approaching this issue with full responsibility. It is better to visit the doctor several times to make sure that the chosen medicine is safe, rather than worry about possible unpleasant consequences. Before using any of the described products, read the instructions.
Instructions for use. Contraindications and release form.
INSTRUCTIONS
for use of the drug
NO-SHPA
Compound
Solution for intravenous and intramuscular injection 1 amp. (2 ml)
active substance:
drotaverine hydrochloride 40 mg
excipients: sodium disulfite (sodium metabisulfite) - 2 mg, ethanol 96% - 132 mg, water for injection - up to 2 ml
Tablets 1 tablet.
active substance:
drotaverine hydrochloride 40 mg
excipients: magnesium stearate - 3 mg; talc - 4 mg; povidone - 6 mg; corn starch - 35 mg; lactose monohydrate - 52 mg
pharmachologic effect
antispasmodic.
Indications of the drug No-shpa®
- spasms of smooth muscles associated with diseases of the biliary tract: cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis;
- spasms of smooth muscles of the urinary tract: nephrolithiasis, urethrolithiasis, pyelitis, cystitis, bladder tenesmus;
As adjuvant therapy(if oral therapy is not possible):
- spasms of smooth muscles of the gastrointestinal tract: peptic ulcer stomach and duodenum, gastritis, spasms of the cardia and pylorus, enteritis, colitis;
- gynecological diseases: dysmenorrhea.
40 mg tablets:
- spasms of smooth muscles, in diseases of the biliary tract: cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis;
- spasms of smooth muscles of the urinary tract: nephrolithiasis, urethrolithiasis, pyelitis, cystitis, bladder spasms.
As an adjuvant therapy:
- spasms of smooth muscles of the gastrointestinal tract: peptic ulcer of the stomach and duodenum, gastritis, spasms of the cardia and pylorus, enteritis, colitis, spastic colitis with constipation and irritable bowel syndrome with flatulence after excluding diseases manifested by the syndrome acute abdomen(appendicitis, peritonitis, ulcer perforation, acute pancreatitis);
- tension headaches;
- dysmenorrhea.
Contraindications
Solution for intravenous and intramuscular administration:
- hypersensitivity to sodium disulfite (see section " special instructions»);
- severe chronic heart failure;
- childhood (use of drotaverine in children in clinical studies not studied);
- breastfeeding period (no clinical studies available).
With caution: arterial hypotension (danger of collapse, see “Special Instructions”); pregnancy (see “Use during pregnancy and lactation”).
Pills:
- hypersensitivity to the active substance or any of the excipients of the drug;
- severe liver or kidney failure;
- severe heart failure (low cardiac output syndrome);
- children under 6 years of age;
- breastfeeding period (no clinical studies);
- rare hereditary galactose intolerance, lactase deficiency and glucose-galactose malabsorption syndrome (due to the presence of lactose in the drug).
With caution: arterial hypotension; pediatric patients (lack of clinical experience applications); pregnancy (see “Use during pregnancy and lactation”).
Use during pregnancy and breastfeeding
As shown by reproductive studies in animals and retrospective studies of clinical data, the use of drotaverine during pregnancy had neither teratogenic nor embryotoxic effects. Despite this, when using the drug in pregnant women, caution should be exercised and the drug should be prescribed only after carefully weighing the benefit-risk ratio.
Due to the lack of necessary clinical data, it is not recommended to prescribe during lactation.
Side effects
Below are the adverse reactions observed in clinical studies, divided by organ system, indicating the frequency of their occurrence in accordance with the following gradation: very often (≥10%), often (≥1.<10%); нечасто (≥0,1, <1%); редко (≥0,01, <0,1%); очень редко, включая отдельные сообщения (<0,01%); неизвестная частота (по имеющимся данным частоту определить нельзя).
From the cardiovascular system: rarely - rapid heartbeat, decreased blood pressure.
From the side of the central nervous system: rarely - headache, dizziness, insomnia.
From the gastrointestinal tract: rarely - nausea, constipation.
From the immune system: rarely - allergic reactions (angioedema, urticaria, rash, itching) (see section “Contraindications”).
Local reactions (solution for intravenous and intramuscular administration): rarely - reactions at the injection site.
Interaction
Solution for intravenous and intramuscular administration
Levodopa. PDE inhibitors like papaverine reduce the antiparkinsonian effect of levodopa. When prescribing drotaverine simultaneously with levodopa, increased rigidity and tremor may occur.
Papaverine, bendazole and other antispasmodics (including m-anticholinergics). Drotaverine enhances the antispasmodic effect of papaverine, bendazole and other antispasmodics, including m-anticholinergics.
Tricyclic antidepressants, quinidine and procainamide. Increases hypotension caused by tricyclic antidepressants, quinidine and procainamide.
Morphine. Reduces the spasmogenic activity of morphine.
Phenobarbital. Strengthening the antispasmodic effect of drotaverine.
Pills
Levodopa. PDE inhibitors like papaverine reduce the antiparkinsonian effect of levodopa. When prescribing drotaverine simultaneously with levodopa, increased rigidity and tremor may occur.
Other antispasmodics, including m-anticholinergics. Mutual enhancement of antispasmodic action.
Drugs that are significantly bound to plasma proteins (more than 80%). Drotaverine binds significantly to plasma proteins, mainly albumin, γ- and β-globulins (see “Pharmacokinetics”). There is no data on the interaction of drotaverine with drugs that significantly bind to plasma proteins, however, there is a hypothetical possibility of their interaction with drotaverine at the level of binding to protein (displacement of one of the drugs by another from binding to the protein and an increase in the concentration of the free fraction in the blood of the drug with a less strong binding to protein), which could hypothetically increase the risk of pharmacodynamic and/or toxic side effects of this drug.
Directions for use and doses
Solution for injection: IM, IV, slowly. Adults: the average daily dose is 40–240 mg, divided into 1–3 intramuscular injections. For acute renal and gallstone colic - 40–80 mg IV, slowly (duration of administration is about 30 s).
Tablets: orally.
Adults. Typically, the average daily dose in adults is 120–240 mg (the daily dose is divided into 2–3 doses). The maximum single dose is 80 mg. The maximum daily dose is 240 mg.
Children. Clinical studies using drotaverine have not been conducted in children.
In case of prescribing drotaverine to children:
- for children 6–12 years old, the maximum daily dose is 80 mg, divided into 2 doses.
- for children over 12 years of age, the maximum daily dose is 160 mg, divided into 2–4 doses.
Duration of treatment without consulting a doctor. When taking the drug without consulting a doctor, the recommended duration of taking the drug is usually 1-2 days. If pain does not decrease during this period, the patient should consult a doctor to clarify the diagnosis and, if necessary, change therapy. In cases where drotaverine is used as an adjuvant therapy, the duration of treatment without consulting a doctor may be longer (2-3 days).
Method for assessing effectiveness. If the patient can easily independently diagnose the symptoms of his disease, because... They are well known to him, then the effectiveness of treatment, namely the disappearance of pain, is also easily assessed by the patient. If within a few hours after taking the maximum single dose there is a moderate decrease in pain or no decrease in pain, or if the pain does not decrease significantly after taking the maximum daily dose, it is recommended to consult a doctor.
Overdose
There are no data on drug overdose.
Treatment: In case of overdose, patients should be under medical supervision and, if necessary, treated symptomatically and aimed at maintaining basic body functions (including induction of vomiting or gastric lavage).
special instructions
Injection
Contains sodium disulfite, which may cause allergic-type reactions, including anaphylactic symptoms and bronchospasm in sensitive individuals, especially those with a history of asthma or allergic diseases. In case of hypersensitivity to sodium disulfite, parenteral use of the drug should be avoided (see “Contraindications”). When administering drotaverine intravenously in patients with low blood pressure, the patient should be in a horizontal position due to the risk of collapse.
Impact on the ability to drive a car or perform work that requires increased speed of physical and mental reactions.
During the treatment period, it is necessary to refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Pills
Contains 52 mg of lactose in each tablet. This may cause gastrointestinal disturbances in patients suffering from lactose intolerance. The tablets are not suitable for patients suffering from lactose deficiency, galactosemia or impaired glucose/galactose absorption syndrome (see “Contraindications”).
Impact on the ability to drive a car or perform work that requires increased speed of physical and mental reactions
When taken orally in therapeutic doses, drotaverine does not affect the ability to drive a car or perform work that requires increased attention. If any side effects occur, the issue of driving and operating machinery requires individual consideration. If dizziness occurs after taking the drug, you should avoid engaging in potentially hazardous activities.
Conditions for dispensing from pharmacies
Solution for intramuscular and intravenous administration. On prescription.
Pills. Over the counter.
Storage conditions for No-shpa®
At temperatures below 30 °C.
Keep out of the reach of children.
Shelf life of the drug No-shpa®
5 years.
