Pimafucin is a truly invaluable drug in the treatment of various kinds fungal infections of the skin and mucous membranes. The drug belongs to the antifungal polyene antibiotic wide range actions. The medicine is also prescribed for various types, and for otomycosis, and for external otitis caused by fungi, and for candidiasis of the skin, nails, intestines, and vagina. Often doctors, in the absence of other such harmless drugs for such diseases, prescribe this particular drug during pregnancy. After all, the use of Pimafucin is allowed at all stages of pregnancy and during breastfeeding. At least, because there is no data on adverse effects on the fetus.
Pimafucin is produced in three dosage forms. These can be film-coated tablets, usually 20 pieces per package. These can be - suppositories - vaginal - usually three pieces per package. Pimafucin is also available in a cream for external use, 2%, 30 g per tube. And pimafucin is also produced in the form of a suspension for local application 2.5% - in 20 ml bottles complete with a pipette.
One tablet or one suppository of Pimafucin contains 100 mg of natamycin. One gram of cream contains 20 mg of natamycin, and 1 ml of Pimafucin suspension contains 25 mg.
As you might have guessed from the composition of the drug, active substance in Pimafucin - natamycin. It's all about the mechanism of its action - natamycin. It binds sterols of cell membranes, disrupting their integrity and functions, and leads to death harmful microorganisms. Therefore, natamycin is not actually absorbed from gastrointestinal tract, from the surface of the skin and mucous membranes. If the drug is taken in tablets, it acts only in the intestines.
The dosage of the drug is prescribed by the doctor, who also considers the most acceptable form of release for the pregnant woman. For the expectant mother, as a rule, the best option- these are suppositories, but there are often cases when the drug is prescribed in other dosage forms.
The most common disease for which Pimafucin is prescribed during pregnancy is. This is due to the fact that a woman experiences hormonal changes during pregnancy. The immune system of the expectant mother is greatly weakened, the body’s natural defenses are correspondingly reduced, and therefore disruptions to the normal bacterial flora often occur.
Side effects that may occur when using Pimafucin are nausea, diarrhea (they occur especially often in the first days of use, but disappear quickly with treatment).
As for skin irritations, they are also possible. A burning sensation is also possible.
If the disease is chronic or advanced, then Pimafucin cream may also be prescribed for use, for example, as tablets. Ban on sex life doctors do not diagnose (unless there are any contraindications related to the course of pregnancy), but it is very advisable to carry out full examination sexual partners. If the husband is also diagnosed with an infection, he will also have to undergo a course of treatment. At the same time, it is very advisable to use barrier contraception during sexual intercourse.
Especially for- Maria Dulina
From Guest
I also treated thrush with pimafucin, it helped, and the thrush never came back.
From Guest
I was treated for thrush during pregnancy, since nothing was possible, I was treated with pimafucin. It helped well, the thrush went away and did not return.
During pregnancy, a woman's body experiences great amount changes, and they are not always positive. Hormonal changes, increasing stress on the body and a common decrease in immunity are the main factors that provoke the occurrence of vaginal candidiasis. Thrush is an unpleasant but harmless disease that can be easily treated drug treatment. The main thing is not to start it to the stage when serious therapy is already required. This is especially true for pregnant women, because an increase in blood sugar levels provokes the growth of fungal microorganisms.
IN given time There are a huge variety of antifungal agents, but not all are allowed to be used while expecting a child. Pimafucin is an antifungal and antibacterial agent a wide spectrum of action, which compares very favorably with other products presented in pharmacy kiosks. A huge advantage is the ability to use it at all stages of pregnancy. What also attracts women is the low toxicity of the product and the large number of release forms.
Pimafucin - remedy complex action, which has a destructive effect on fungi and bacteria. The spectrum of action of this antibiotic is very wide, which makes it effective against most pathogenic microorganisms.
The medicinal properties are due to the influence of the main active ingredient – natamycin. This component not only has a detrimental effect on the cells of pathogenic bacteria, but also prevents the spread of the disease throughout the body. The effectiveness of the drug in the case of thrush is due to the fact that natamycin has an inhibitory effect on the fungus of the genus Candida, which is the causative agent of this unpleasant disease.
What pathogenic microorganisms does the drug affect:
- pathogenic fungi;
- yeast-like bacteria;
- dermatophytes, etc.
Each specific case uses its own form of medication. The choice of treatment tactics depends on the location of the lesion, as well as the stage at which the disease is located.
Pharmacological forms of release:
- Vaginal suppositories (suppositories) – the package contains three suppositories containing 100 mg of active ingredient.
- Cream for external use, with a two percent concentration of natamycin. The amount of ointment in the tube is 30 ml.
- Tablets, the shell of which dissolves only in the intestines, and therefore the maximum therapeutic effect. The dosage is 100 mg. The number of tablets in a jar is 20 pcs.
A significant advantage of Pimafucin is that it does not act systemically, and therefore its use is safe at various stages of pregnancy, including in the first trimester. There are also very few contraindications associated with this. The drug is not approved for use only in cases where individual intolerance to one or more components of the drug occurs.
Indications and contraindications
First of all, it is worth noting that the use of any medical product, no matter how harmless it may be, is only possible under the supervision of a specialist. Self-medication during pregnancy is strictly prohibited. Only a doctor can assess the risks and make a decision regarding the advisability of using a particular drug.
Indications for use of Pimafucin
- Infectious diseases whose pathogens show sensitivity to the effects of natamycin.
- Fungal infection of the gastrointestinal tract, caused by the uncontrolled use of antibiotics for the treatment of infectious diseases.
- Candidiasis affecting the small intestine.
- Fungal infection of the ear canal.
- Mycosis of the skin and its appendages (nail plates), including its chronic form.
Most often, it is the latter disease that is the indication for use. antimicrobial agent . Hormonal changes and general decline immunity are the main factors provoking the growth of the population of pathogenic fungi in the vagina. Against the background of candidiasis of the mucous membrane, an inflammatory process occurs, which, over a long period of time, can provoke. In addition, during the delivery process, the child may become infected, which will lead to candidal stomatitis.
Pimafucin suppositories during pregnancy, according to the instructions for use, can be used at any stage of pregnancy. This is due to the fact that natamycin has only a local effect and is not absorbed into the blood, and, accordingly, cannot pass through the placental barrier.
Contraindications for use
A direct contraindication to the use of the drug is intolerance to the components of the drug. This can provoke an allergic reaction, which will manifest itself in the form of itching and burning in the vaginal area. Otherwise, the drug is absolutely safe.
The use of the product may intensify the manifestations. This often happens on the first day after starting treatment. But in further symptoms pass without any intervention. Therefore, you should not worry about a slight deterioration in your condition.
Can Pimafucin be used during pregnancy?
According to preliminary studies that occurred during testing of the drug, Pimafucin does not cause toxic effects on the fetus. However, despite this, the use of a natamycin-based product is possible subject to certain conditions.
- Immediately after the appearance of unpleasant symptoms, you must contact a gynecologist to get all tests done. Initially, there may not be a characteristic cheesy discharge, but constant itching in the perineum definitely indicates the development of an inflammatory process.
- Medicine for thrush can only be prescribed by a doctor and only after appropriate tests.. Not all medications are equally permitted during pregnancy.
- Based on the clinical course of the disease, a specific treatment tactic is selected. Light forms do not require the use of tablets; it is quite enough local treatment using suppositories and ointments. However, in severe cases of candidiasis or chronic inflammation it is necessary to choose a systematic approach to therapy.
- Taking the drug should not exceed two weeks. If recovery does not occur during this period, then a different treatment tactic is chosen.
Pimafucin in the first trimester
On early stages During pregnancy, absolutely all organ systems of the future baby are formed. Therefore, the effect of medications on a growing organism can contribute to the occurrence of pathologies. This is precisely why caution is associated with the use of medications during this period.
Under what conditions can the drug be used in the early stages of pregnancy:
- The use of an antifungal agent is possible when the use of more soft methods has no effect. Initially, the gynecologist may prescribe the use of douches and herbal baths. And only if they are ineffective does he prescribe a prescription for the use of the medicine.
- The use of tablets at this stage is inappropriate. Despite the fact that the instructions do not suggest negative influence on the formation of the fetus of the main active substance, it is not worth exposing the child to additional danger.
- Pimafucin in the form of suppositories is allowed to be used during pregnancy in the 1st trimester. The action of the drug in this case is directed to the area of inflammation and, at the same time, does not have a negative effect on the child.
Did you know? The cause of thrush in the first trimester is most often associated with decreased immunity. This is completely physiological, because the body reduces its protective functions, in order to avoid - antenatal fetal death - due to its rejection immune system mother.
Pimafucin in the second trimester
The drug is taken for the same indications as at an earlier date.. By this time, the placental barrier has already been formed, and therefore the child is perfectly protected from external influence. Pimafucin is completely approved for use during pregnancy in the 2nd trimester. The tablet form can also be used, but only for direct indications, when local impact not enough.
To maintain healthy microflora, concomitant use of Clotrimazole suppositories may be prescribed. It is used in the same course as Pimafucin.
Pimafucin in the third trimester
The closer to the time of delivery, the greater the need for timely treatment thrush. The fact is that here we are talking about the health of the unborn child, and not about the well-being of the mother.
There are certain rules for taking the drug in the third trimester:
- The pregnant woman must be completely healthy before giving birth. Candidiasis is dangerous for the baby and increases the risk of postpartum inflammation.
- To achieve a better result, preference is given to a combination form of therapy.
- Pimafucin - suppositories during pregnancy in the 3rd trimester are used both in conjunction with tablets and after completion of the main course. The decision regarding the regimen of use is made by the gynecologist, based on the course of the disease.
- Taking the drug for longer than two weeks is not advisable. In this case, the therapeutic effect is not enhanced, but only increases the risk of adverse reactions.
Instructions and dosage
The duration and regimen of treatment should always be chosen by the attending physician.. Self-medication while expecting a child can lead to unpredictable consequences. Each form of the drug requires various methods use, therefore it is necessary to dwell in more detail on each of them.
Vaginal suppositories
Pimafucin suppositories can be used during pregnancy according to the instructions, regardless of the gestation period. The course of treatment ranges from three to seven days, depending on the severity of the situation. The amount of active ingredient in each suppository is 100 mg.
A huge advantage of using this form of the drug is its complete dissolution and uniform distribution over the entire inner surface of the vagina. Thanks to this, complete coverage of the affected area and destruction of pathogenic bacteria is achieved. The product primarily affects cell membranes fungi, destroying them.
The administration of the suppository is prescribed once a day before bedtime. The product dissolves quite quickly and when vertical position may leak from the perineum.
Cream for external use
This form is used to treat fungal infections of the skin and nail plates. Necessary local use ointment on the affected area. The course of treatment is from one to two weeks, subject to regular use of the drug two to four times a day.
At very difficult situations treatment is prescribed to both partners. For example, if thrush is detected in a woman, it is recommended that the creamy form be used by a partner. In this case, the head of the penis is lubricated several times a day in order to preventive therapy candidiasis.
The concentration of the active substance in the cream is 2% of total number components.
Tablet form
Pimafucin tablets during pregnancy are used as part of joint therapy for infections that cannot be treated only locally. Use in the early stages of pregnancy is possible, but only if the intended benefit outweighs possible risks for the fetus. Late use is completely safe.
The product is used four times, one tablet, for a period of seven to ten days. It is advisable to take tablets after meals to avoid unpleasant gastrointestinal symptoms. If the dosage regimen and dosage are followed, the use of the drug does not cause complications in either the pregnant woman or the fetus. The dosage is 100 mg of active substance per tablet.
Side effects
Depending on the form of the product used, different unpleasant symptoms at the place of use. The drug is usually well tolerated by patients and adverse reactions do not arise, but they are still possible.
Side effects from the use of Pimafucin:
- The tablet form can cause gastrointestinal disorders. Immediately after starting use, nausea, bloating and heartburn may occur for a couple of days. However, as the course continues, the symptoms disappear.
- After applying the cream or inserting a suppository, burning and redness may occur at the site of use.. This shows the presence of mild allergic reaction, but most often does not require any additional therapy.
Often worsens during pregnancy chronic diseases or diseases appear that have not bothered you before. The fungus can cause discomfort and also affect the well-being of the mother and the health of the unborn baby. Will Pimafucin help in this case and is it safe?
Is Pimafucin harmful during pregnancy?
Pimafucin is a local antibiotic that is indicated for the treatment of fungal diseases of the mucous membranes and skin. According to the instructions, this drug can be used during pregnancy. It is stated that there is no data on the effect on the fetus. Most often, expectant mothers are prescribed this medicine for thrush, or candidiasis.
Of course, no clinical trials medications are not used on pregnant women, but this drug is considered one of the safest.
Pimafucin can be prescribed by a doctor even in early pregnancy. In the first trimester fungal diseases women are potentially dangerous for the unborn child: there is a possibility of miscarriage or frozen pregnancy. In the second and third trimesters, the infection is fraught with intrauterine infection of the fetus. Also, during childbirth, the baby can become infected with a fungal disease. Therefore, throughout pregnancy it is important to listen to your condition and start treatment on time if necessary. However, there is another medical opinion.
Thrush is considered physiological norm pregnancy, because enhanced growth fungus is observed in 80–90% of pregnant women. It is not dangerous for both the pregnant woman and the fetus and newborn.
E.P. Berezovskaya
http://www.komarovskiy.net/faq/beremennost-i-molochnica.html
Composition, action and release forms
The active ingredient of the drug Pimafucin is the antibiotic natamycin. It acts only locally and is not absorbed into the blood. Its content varies depending on the form of release of the drug.
Pimafucin is available in suppositories, tablets and cream form. For thrush, it is most often prescribed vaginal suppositories. If the source of infection is in the intestines, the doctor may supplement the treatment regimen with pills. In such cases, the cream is used when the external genital organs of a woman and her sexual partner are affected by the fungus.
Photo gallery: Pimafucin release forms
Pimafucin tablets are intended for oral administration for intestinal candidiasis 
Pimafucin cream has a local antifungal effect on the skin and mucous membranes 
Vaginal suppositories Pimafucin is most often prescribed for thrush
What it helps with: thrush, colpitis and other indications
In most cases, during pregnancy, vaginal candidiasis is treated with Pimafucin, but the spectrum of use of this local antibiotic is wide, which allows it to be successfully used for other fungal infections. Indications are slightly different for different forms release of the drug.
Tablets can be prescribed for:
- acute pseudomembranous and atrophic candidiasis;
- otomycosis, external, caused by fungi or complicated by candidiasis;
- candidiasis of the skin and nails;
- intestinal candidiasis;
- vaginitis (colpitis), vulvitis, vulvovaginitis, balanoposthitis;
- dermatomycosis.
Suppositories are successfully used for:
- vaginitis();
- vulvitis;
- vulvovaginitis.
The cream may be prescribed in the following cases:
- vulvitis;
- vulvovaginitis;
- balanoposthitis;
- candidiasis of the skin and nails;
- external otitis with candidiasis;
- ringworm.
Despite the safety of the drug, you should not self-medicate. Only a doctor can determine accurate diagnosis and select the appropriate form of medication and individual therapy regimen.
Instructions for safe use
Features of using candles, tablets and cream
According to the instructions, Pimafucin in suppositories should be used once a day for 3–6 days. The suppository should be administered at night in a lying position. This is necessary so that the medicine released when the candle melts does not leak out.
The drug in tablets is prescribed 4 times a day. The course usually lasts no more than 1 week. Treatment with tablets can be combined with the use of suppositories and cream.
Usually, after the disappearance of unpleasant symptoms, Pimafucin therapy is continued for several more days to prevent recurrence of the infection.
The final duration of treatment for all forms of the drug is determined by the doctor individually, taking into account the patient’s condition.
Contraindications and side effects
Among the direct contraindications in the instructions for Pimafucin, only increased sensitivity to natamycin and auxiliary components of the drug. Local side effects - vaginal irritation and burning sensation - may appear when using Pimafucin in suppositories or in the form of a cream. They are short-term in nature and usually do not require discontinuation of the drug. Tablets have a wider range side effects:
- nausea,
- diarrhea,
Individual reactions associated with intolerance to the components of the drug are possible.
The active substance natamycin does not penetrate the placenta and into the bloodstream system connecting the body of the mother and the child. Therefore, Pimafucin is considered safe during pregnancy. If any serious by-effect If a woman does experience this, treatment should be stopped, since there is a possibility that a similar negative effect could occur in relation to the fetus. For example, if a mother has an allergy, the baby may be born with a tendency to the same reaction.
How can you replace Pimafucin in different trimesters of pregnancy?
It also happens that Pimafucin does not help cope with fungal diseases that cause severe discomfort. Some women note that after a course of treatment with this drug, discharge and other unpleasant symptoms continue to bother them. In this case, you need to consult your doctor and choose another drug that is safe during pregnancy.
Table: analogues of Pimafucin, clotrimazole and other antibiotics for the treatment of fungal diseases at different stages of pregnancy
| Medicine | Release form | Active substance | Contraindications | Side effects | |
| Ecofucin | Vaginal suppositories | Natamycin | Hypersensitivity to the components of the drug | - |
|
| Vaginal suppositories | Natamycin | - |
|
||
| Vaginal tablets | Not recommended for use during pregnancy (especially in the first trimester). |
|
|||
| The question of prescribing the drug should be decided by the doctor individually. In this case, the use of an applicator is not recommended. | Rarely - a slight burning sensation immediately after administration of the tablet | ||||
| Not recommended for use in the first trimester of pregnancy. | Allergic reactions | |||
| Pills |
|
|
|||
| Vaginal capsules |
| Not recommended for use in the first trimester of pregnancy. In the second and third trimesters, use is possible only as prescribed by a doctor in cases where the expected benefit to the mother outweighs the potential risk to the fetus. |
|
||
Photo gallery: medications prescribed to pregnant women for fungal infections
Polygynax is not recommended for use in the first trimester of pregnancy 
From the manufacturer's point of view, Nystatin can be taken during pregnancy 
Vaginal tablets Terzhinan may cause mucosal irritation and allergic reactions. 
Clotrimazole is not recommended for use in the first trimester of pregnancy. 
Candid-B6 is not prohibited during pregnancy, but the benefit to the mother must be weighed against the risk to the fetus 
Primafungin - pharmacological analogue Pimafutsina
Due to the heavy load on a woman’s immune system during pregnancy, it is more difficult for her body to protect itself from infection. Most often, expectant mothers complain about manifestations of thrush, which is confirmed after undergoing a genital smear. In such cases, experts recommend treatment with Pimafucin - it is safest during pregnancy. Before use, you must carefully read the information about the characteristics of its effects, dosage and contraindications.
Pimafucin - what kind of medicine is this?
Pimafucin is an antifungal antibacterial agent from the macrolide family, which has a bacteriostatic effect by binding styrene and blocking the process of joining fungal cell membranes. The active component of the drug is a broad-spectrum antimycotic – natamycin, which acts on the cell walls of pathogenic microorganisms that cause candidiasis, preventing their reproduction.
Experts use this medicine to treat not only thrush caused by candida albicans, but also any other fungal infection:
- ear inflammation (external and otitis media);
- stomatitis;
- mycosis of the nail plate and skin;
- inflammation of the vulva and vaginal mucosa (vulvovaginitis, vaginitis).
It is even prescribed to pregnant women infected with fungi. It is considered absolutely safe due to the fact that it has a local therapeutic effect - it does not penetrate into circulatory system and through the placental barrier, therefore, according to medical statistics, not a single case of a negative effect of Pimafucin on the development of fetal organ systems has been recorded.
Release form, dosage and effect on the body
Pimafucin is available in different dosage forms depending on the area of application (orally or externally). Only a doctor can select the type and dosage of the drug or combine both forms:
- Ointment or cream 2% (1 gram contains 20 mg of natamycin) for external use, odorless, white or light yellow in color with a uniform thick texture. The cream is packaged in a 30 gram aluminum tube, which comes with cardboard box and detailed instructions.
- Vaginal suppositories in the shape of a torpedo, milky white containing 100 mg of antibiotic in 1 suppository. Additional substances: adipic acid, sodium bicarbonate, polysobate, cetyl ethyl, solid fat, sorbitan trioleate. The drug is packaged in cardboard boxes with three 3 or 6 strips.
- Round, white, enteric-coated tablets. 1 piece contains 100 mg of natamycin and 160 mg of auxiliary components: potato starch, lactose monohydrate, magnesium stearate, polyvinlpyrrolidone. The tablets are packaged in 20 pieces in dark glass bottles and cardboard boxes with instructions.
Instructions for use of the drug
Experts emphasize that not a single drug, even the safest one, can be selected independently. Pimafucin also has its own characteristics of use and course duration, depending on the form of release:
- The cream is applied to the affected areas of the skin or nails, placed in ear canal up to 4 times a day during the course, which is individually selected by the treating specialist, until the symptoms completely disappear.
- Suppositories are treated for 5 days or a week. Insert deep into the vagina, 1 piece per day. It is necessary to carry out hygiene procedures, lie on your side and wait a little until it dissolves.
- The tablet form of Pimafucin is taken for a week, 1 tablet 4 times a day.
When planning
There is an opinion that when planning a child, Pimafucin in the form of suppositories can affect the fertility of sperm entering the vagina. Experts do not confirm this information and suggest taking everything before conceiving. necessary tests, then undergo treatment and begin conceiving a healthy baby.
1st trimester
In the first three months after pregnancy, a woman’s hormonal levels change dramatically and, as a result, symptoms of thrush may appear, so the gynecologist prescribes Pimafucin in the form of suppositories. Tablets are not recommended in the first trimester due to toxicosis.
2nd trimester
Treatment of fungal infection in the period from 4 to 6 months of pregnancy (2nd trimester) becomes much easier, because you can select other, more potent drugs if Pimafucin does not cope with developing disease. In addition, the baby is protected by the mucous plug of the uterus and infection cannot penetrate to it. The specialist prescribes the drug in tablet form so that by the time of birth the child passes through healthy birth canal and didn't get infected.
Doctors often recommend simultaneous treatment both sexual partners and prescribe Pimafucin tablets in combination with another antifungal ointment or suppositories. The duration of treatment and additional medications are determined by the doctor according to individual indications after tests (vaginal smear, bacterial culture urine).
3rd trimester
Experts recommend taking a preventive course of treatment before childbirth (at 38 weeks) if there was a case of recurrent thrush during the planning period or in the early stages of pregnancy. Also, in the last stages of pregnancy, intestinal candidiasis may appear, which requires taking Pimafucin for 3 days.
For thrush
Thrush does not pose a danger to the fetus, it only causes discomfort future mother. However, there is a possibility that the baby may become infected during the process. labor activity, therefore it is necessary to treat thrush, especially since Pimafucin does not affect intrauterine development child, but only eliminates fungi and the consequences of their activity.
Side effects and contraindications
If the instructions are carefully followed, Pimafucin does not have a negative effect on the body; in rare cases, adverse reactions may occur. In the first days of taking the pills, nausea, loss of appetite, and vomiting may occur. When using suppositories and ointments, local allergic reactions may occur in the form of itching, burning and redness of the skin areas treated with the drug.
Pimafucin has no contraindications and experts can recommend it during pregnancy and during breastfeeding. Restriction of use may be due to individual intolerance (lactase or fructose deficiency) or allergic reactions to any auxiliary component of the drug.
Are there any analogues of the drug?
With absence therapeutic effect from Pimafucin, the doctor can replace it with the drug similar action, but with a different active or excipient. Pharmaceutical industry offers many analogues:
- Natamycin is a drug containing a similar active ingredient, but without auxiliary components that soften the effect of the antibiotic on the body, which is why Natamycin causes serious harm digestive system sick.
- Funzol is an antifungal agent based on fluconazole in the form of a solution for infusion, powder for suspensions, capsules and syrup. It has many contraindications, including the period of breastfeeding.
- Ecofucin – complete analogue Pimafucin in the form of suppositories, which costs less (200 - 300 rubles). Ecofucin is most often prescribed to pregnant women to treat thrush.
- Funginok – tablets with the active ingredient ketonazole (200 mg) are used for the treatment of fungal infections of the skin. Prohibited for use during pregnancy.
- Terzhinan - tablets for insertion into the vagina with the following active ingredients: ternidazole, neomycin sulfate, nystanin, prednisolone sodium metasulfobenzoate. They are used for an inflammatory process complicated by additional pathology, and also require a longer course of treatment and can cause allergies. Terzhinan is prohibited during pregnancy, because the substances penetrate the placental protection and negatively affect the fetus.
- Clotrimazole is a medicine that has a more aggressive effect on the body and causes intoxication in case of overdose (we recommend reading: Clotrimazole suppositories: instructions for use in the 1st trimester of pregnancy). Not recommended for the treatment of pregnant women in the 1st trimester and during breastfeeding.
- Livarol - vaginal suppositories with active substance ketoconazole. Prescribed in case of recurrence of thrush, if drugs with a more gentle action do not cope. Livarol can provoke allergic reactions and severe irritation of mucous membranes and skin.
- Hexicon is an antiseptic drug based on chlorhexidine bigluconate, available in several forms (gel, suppositories, tablets) (we recommend reading: Hexicon suppositories: indications for use during pregnancy). It can be used at all stages of pregnancy, but not combined with iodine and soap solutions.
- Betadine is an antibacterial and antiseptic drug that is often used to treat wounds, burns, postoperative sutures. The drug contains povidone-iodine, which can affect the functioning of the thyroid gland.
From this article you will learn: how and when to use Pimafucin for thrush. What kind of drug is this, can it be used not only by women, but also by men. Mechanism of action of Pimafucin. Release forms: tablets, suppositories, cream.
Article publication date: 10.29.2017
Article updated date: November 28, 2018
Pimafucin is a drug with antifungal activity from the group of antimicrobial agents - macrolides. This is the trade name of the active ingredient Natamycin. Pimafucin is produced by Italian pharmaceutical company, with which it is quite connected high price medicines.
This remedy is highly effective against yeast fungi of the genus Candida, which cause various shapes candidiasis, including genital lesions or thrush. Therefore, the drug is very often prescribed for the treatment of candidiasis. It can also be prescribed for the treatment of a different type of fungal infection (not candidiasis), but with a lower therapeutic effect.
The advantages of Pimafucin in the treatment of candidal inflammation over other drugs from the group of antifungal agents:
- there is no development of fungal resistance to the drug during therapy;
- causes complete death of the pathogen;
- shows high results in terms of complete cure;
- low toxicity of the drug (general effect on body systems);
- minimal amount side effects and the rarity of their development;
- can be used in pregnant and lactating women, small children under 12 years of age;
- does not penetrate into the general bloodstream when applied topically;
- available in all dosage forms, except solution (tablets, cream, suppositories);
- can be used in women and men;
- a small number of contraindications for use.
Relative high cost (from 230 to 800 rubles, depending on the form of release and dosage) is the only negative quality medicine, which does not allow its wider application.
Only a doctor should prescribe therapy for thrush and other types of candidal infections with Pimafucin. You can contact a gynecologist, urologist, dermatovenerologist or otolaryngologist if there is damage to the oral cavity.
Indications for use
Pimafucin is used to treat inflammatory processes caused by yeast or yeast-like fungi. Most often used in the treatment of candidiasis affecting:
- organs genitourinary system in women and men (labia, vagina, urethra, glans penis and foreskin);
- skin, its folds and skin derivatives ( hair follicles, nails and periungual bed);
- ENT organs (tongue, lips, gums, pharynx, larynx, tonsils, sinuses, ears);
- digestive tract (esophagus, stomach, small and large intestine).
Pimafucin suppositories for thrush, as well as tablets and cream, are very effective in cases of:
Acute, newly diagnosed form of pathology in any of the above localizations.
An illness that occurs while taking antibacterial, hormonal and chemotherapeutic drugs.
Before and after surgical interventions on the genitals, intestines, esophagus, stomach for the purpose of preparing, preventing and treating candidal infections.
When therapy needs to be carried out during pregnancy or during breastfeeding.
If there is a violation of the liver and kidneys against the background of their chronic illness with decreased organ function (in blood samples high level bilirubin and creatinine).
The need for treatment of children under 12 years of age, including newborns and premature babies.
Pimafucin is the main medicine in the treatment of fungal inflammation of the intestines, as the only drug to which there is no resistance of the yeast flora (unlike Nystatin) and no general systemic manifestations (like Fluconazole and Itraconazole).
When should Pimafucin not be used?
The peculiarity of Pimafucin is practically complete absence contraindications for use. The drug should not be used if there is an individual allergic reaction, high sensitivity or intolerance:
- Natamycin - for all forms of medication;
- starch, lactose, povidone, sucrose, bee products, talc, kaolin - for the tablet version of Pimafucin;
- polysorbate, adipic acid, sodium bicarbonate, cetyl alcohol - for vaginal suppositories.
Mechanism of drug action
The active ingredient Pimafucin blocks sterols, the main active elements of the fungal wall. This leads to disruption of their exchange function nutrients With external environment. The integrity of the pathogen cells is disrupted, and the microorganisms quickly die.
When Natamycin is applied to the skin and mucous membranes, the drug penetrates well into the inner layers, affecting all parts of the fungal colony, but is not absorbed into blood vessels. Therefore, the medicine does not affect the liver and kidneys.
When taking the tablet form of Pimafucin, its active substance is 85–90% excreted from the intestines with feces - absorption into the systemic circulation is minimal.
Data on drug resistance of fungal infections when clinical application No. The drug always gives high results in the treatment of candidiasis. It can be used for relapses of the disease an unlimited number of times, taking a break for 2-3 weeks.
results laboratory research biological material patient before (left) and after (right) use of Pimafucin. Visible result of fungus suppression
Forms of release of the drug
Treatment regimens: doses and timing
| Dosage form | For which candidiasis should it be used? | How to use | Duration of treatment |
|---|---|---|---|
|
Pills |
Intestines |
1 tab. 4 times a day Drink only water Between meals |
4–6 weeks |
|
Genital organs in both sexes, skin, mucous membranes – as an addition to local therapy |
1–2 weeks |
||
|
Vaginal suppositories |
Genital organs in women |
After hygienic treatment of the external genitalia Strictly in a lying position Before going to bed, insert one candle to the depth of your finger Lie down for at least 30–40 minutes |
3–6–14 days |
|
Skin, skin folds and its derivatives (nails, hair) |
Rinse the application area with warm water Skin - with soap Dry completely Apply the cream in a thin layer (3–5 g) If necessary, apply a bandage on top Do not wash or rinse for an hour |
2–4 weeks |
|
|
Mucous membranes |
When the symptoms of the pathology completely disappear during therapy, continue treatment for another 2-3 days.
When treating a recurrent form of candidiasis, the break in treatment should be at least one week.
Possible Adverse Effects
Negative effects during therapy with Pimafucin occur extremely rarely - the drug is well tolerated by more than 95% of patients. All effects, with the exception of a severe allergic reaction (individual intolerance), do not require discontinuation of treatment and go away on their own within a few days.
Features of application
- In case of treatment of recurrent or chronic form for candidiasis infection, local therapy (suppositories, cream) must be supplemented with a tablet form of the drug to achieve complete cure.
- If menstruation begins during the therapeutic course of Pimafucin, treatment must be interrupted and the course must be started again after the end of bleeding.
- During the treatment of genital candidiasis, you can continue to be sexually active, but use condoms.
- Be sure to examine your partner and, if a fungal infection is detected, treat simultaneously to avoid reinfection candidiasis.
- Natamycin can be combined with other medicines with antifungal action - there will be no decrease in the effectiveness of therapy.
- Pimafucin is approved for use in cases of reduced liver function.
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