Codelac is a combination drug. Codelac Broncho tablets: instructions for use

Registration number: Р N002419/01-170616

Trade (proprietary) name of the drug: Codelanov phyto

International generic name: not assigned

Dosage form: elixir

Composition per 5 ml of the drug:

active substances: codeine phosphate hemihydrate - 4.5 mg, dry thermopsis extract - 10 mg, liquid thyme extract - 1000 mg, dry licorice extract - 165 mg;

Excipients: methyl parahydroxybenzoate (nipagin) - 3.75 mg, propyl parahydroxybenzoate (nipazole) - 1.25 mg, sorbitol (sorbitol) - 3000 mg, water (purified water) - up to 5 ml.

Description

Liquid Brown with a characteristic aromatic odor. During storage, sediment may form.

Pharmacotherapeutic group:

combined antitussive agent (opioid antitussive agent + expectorant).

CodeATX:

Pharmacological properties

Cough suppressant, contains ingredients plant origin. Combined drug.

Codeine reduces excitability cough center, reducing the intensity of cough. In recommended therapeutic doses does not cause depression of the respiratory and cough centers, does not impair the function of ciliated epithelium and does not reduce bronchial secretion. Thermopsis herb has an expectorant effect, manifested in increasing the secretory function of the bronchial glands, increasing the activity of the ciliated epithelium and accelerating the excretion of secretions, increasing the tone of bronchial smooth muscles due to the central vagotropic effect.

Licorice root has an expectorant, anti-inflammatory and antispasmodic effect. Contains glycyrrhizin, which has an antiviral effect, and also potentiates the effect of endogenous glucocorticosteroids, providing anti-inflammatory and antiallergic effects. Due to its pronounced anti-inflammatory activity, glycyrrhizin contributes to the most rapid relief of the infectious and inflammatory process in the respiratory tract.

Thyme herb extract contains a mixture of essential oils that have an expectorant, anti-inflammatory and bactericidal effect due to increased activity of the ciliated epithelium of the mucous membranes of the upper respiratory tract, increasing the amount of secretion from the bronchial mucosa, diluting sputum, accelerating its evacuation and loosening inflammatory plaques. In addition, thyme has weak antispasmodic and reparative properties.

Indications for use

Symptomatic treatment of dry cough of any etiology with broncho pulmonary diseases.

Contraindications

Hypersensitivity to the components of the drug;

Respiratory failure;

Bronchial asthma;

Pregnancy and breastfeeding period;

Taking morphine-like drugs (buprenorphine, nalbuphine, pentazocine);

Drinking alcohol;

Children under 12 years of age;

Children's and adolescence from 12 to 18 years in the presence of respiratory pathology (for example, bronchial asthma and others chronic diseases respiratory tract);

High activity of cytochrome P450 enzymes (CYP2D6).

Use during pregnancy and breastfeeding

The use of Codelanov phyto is contraindicated during pregnancy. If it is necessary to use the drug during lactation, breastfeeding should be discontinued.

Directions for use and doses

Adults and children over 12 years old. Orally, 15-20 ml per day. Daily dose should be divided into 2-3 doses.

Shake before use.

Symptomatic treatment should be short-term (several days).

Side effect

When taken in therapeutic doses, allergic reactions may develop ( itchy skin, urticaria). Possible nausea, vomiting, constipation, headache, drowsiness. With prolonged use, drug dependence to codeine may develop.

Overdose

Symptoms: drowsiness, vomiting, headache, itching, miosis, depression of the respiratory center, bradypnea, arrhythmias, bradycardia, urinary retention, atony Bladder.

Treatment is symptomatic, including restoration of breathing and cardiovascular activity, gastric lavage, administration of respiratory analeptics, atropine and the competitive physiological antagonist of codeine - naloxone.

Interaction with other drugs

It is undesirable to use it with other drugs that inhibit the activity of the central nervous system. nervous system, due to the increased sedative effect and inhibitory effect on the respiratory center: sleeping pills, sedatives, antihistamines, narcotic analgesics morphine derivatives, anxiolytics, antipsychotic drugs. Codeine enhances the effect of ethanol on psychomotor function.

Chloramphenicol inhibits the biotransformation of codeine in the liver and thereby enhances its effect.

When codeine is used in large doses, the effect of cardiac glycosides (digoxin, etc.) may be enhanced, since their absorption increases due to the weakening of peristalsis. Adsorbents, binders and enveloping agents may reduce the absorption of codeine, which is part of the drug, in gastrointestinal tract.

Special instructions:

Long-term treatment with high doses may lead to drug dependence;

Codelan phyto should not be prescribed simultaneously with mucolytic and expectorant drugs;

Before prescribing antitussives, the cause of the cough should be clarified due to the possible need for special treatment;

Athletes should remember that the drug contains codeine and is a doping agent;

Caution should be exercised in case of increased intracranial pressure;

In patients with impaired renal function, codeine excretion is slow, so it is recommended to lengthen the intervals between doses of the drug;

It is prohibited to drink alcohol while taking Codelan Phyto.

Effect on ability to drive vehicles, mechanisms

Due to the possibility of developing a sedative effect, during treatment it is not recommended to use the drug when exercising potentially dangerous species activities that require increased concentration of attention and speed of psychomotor reactions (driving vehicles, working with moving mechanisms, working as a dispatcher and operator).

Release form

Elixir. 50, 100 and 125 ml in dark glass bottles. One bottle with instructions for use and a measuring spoon or one bottle with a multi-page label and a measuring spoon is placed in a cardboard pack.

Storage conditions

Store at a temperature not exceeding 15 °C. Keep out of the reach of children.

Best before date

2 years 6 months. Do not use after the expiration date.

Conditions for dispensing from pharmacies

On prescription.

Marketing authorization holder/organization receiving consumer complaints:

PJSC "OTCPharm", Russia, 123317, Moscow, st. Testovskaya, 10

Manufacturer

OJSC "Pharmstandard-Leksredstva", 305022, Russia, Kursk, st. 2nd Aggregatnaya, 1 a/18.

for one tablet:

active substances: ambroxol hydrochloride (ambroxol) - 20.0 mg, trisodium salt of glycyrrhizic acid (sodium glycyrrhizinate) - 30.0 mg, dry thermopsis extract - 10.0 mg, sodium bicarbonate - 200.0 mg.

Excipients: potato starch- 84.30 mg, microcrystalline cellulose - 150.10 mg, povidone-K25 (kollidon K25) - 26.40 mg, talc - 13.00 mg, stearic acid - 5.20 mg, sodium carboxymethyl starch (sodium starch glycolate, Primodel ) - 11.00 mg.

Pharmacotherapeutic group

Medicines used for coughs and colds. Expectorants, excluding combinations with antitussives. ATS code:

Indications for use

Diseases of the respiratory tract with difficulty in sputum discharge: acute and Chronical bronchitis, pneumonia, chronic obstructive disease lungs (COPD), bronchiectasis.

Contraindications

Hypersensitivity to the components of the drug, peptic ulcer of the stomach or duodenum in the acute stage, pregnancy, lactation, childhood up to 12 years old.

The drug should not be used for pulmonary diseases with a tendency to hemoptysis (cancer, pulmonary tuberculosis).

With caution: liver and/or kidney failure, gastric and duodenal ulcers, bronchial asthma.

Precautionary measures

The drug should not be combined with antitussives that make it difficult to remove sputum.

CODELAC® Broncho tablets should not be taken together with other products containing licorice as serious side effects may occur. side effects, for example, fluid retention in the body, hypokalemia, arterial hypertension, cardiac arrhythmia.

Concomitant use with diuretics, cardiac glycosides, corticosteroids, stimulant laxatives or other drugs that may aggravate electrolyte imbalance is not recommended.

Several cases of severe skin damage have been reported, including Stevens-Jones syndrome and toxic epidermal necrolysis, associated with drugs such as ambroxol. These cases can usually be explained by the severity concomitant diseases or concomitant use of other drugs. If damage to the skin or mucous membranes occurs, consult a doctor immediately and treatment with the drug should be discontinued as a precaution.

Caution must be exercised when using the drug in patients with diseases accompanied by difficulties in sputum evacuation, patients with diabetes mellitus, With portal hypertension, arterial hypertension. In case of increase blood pressure while taking the drug, it is necessary to stop treatment.

One tablet of the drug contains 2.48 mmol (57.09 mg) sodium, which should be taken into account in patients receiving a salt-free diet.

Interaction with other drugsby military means

Combined use with antitussive drugs leads to difficulty in sputum discharge while reducing cough.

The drug increases the penetration of amoxicillin, cefuroxime, erythromycin and doxycycline into the bronchial secretions.

Adsorbents, astringents and coating agents can reduce the absorption of drug components in the gastrointestinal tract.

The combined use of CODELAC® Broncho with antihypertensive drugs may reduce the effect of the latter.

It is not recommended to use CODELAC® Broncho together with cardiac glycosides, corticosteroids, stimulant laxatives or other drugs that may aggravate electrolyte imbalance.

Concomitant use with thiazide and thiazide-like diuretics (hydrochlorothiazide, etc.) increases the risk of developing hypokalemia.

Use during pregnancy and breastfeeding

The use of the drug during pregnancy is contraindicated. If it is necessary to use the drug during lactation, breastfeeding should be discontinued.

Impact on the ability to drive vehicles and operate machinery

There are no known cases of the drug affecting the ability to drive a car or use machinery. No relevant studies have been conducted.

Directions for use and doses

Inside, during meals.

Adults and children over 12 years old: 1 tablet 3 times a day.

In elderly patients, with impaired liver and kidney function, no dose adjustment is required.

Overdose

Symptoms: dyspepsia, nausea, vomiting, diarrhea, increased blood pressure, edema, weight gain. Treatment is symptomatic; gastric lavage is advisable in the first 1-2 hours after taking the drug.

With long-term use (more than 4 weeks) in very high doses, many times higher than recommended, the development of pseudohyperaldesteronism is possible, in rare cases, transient visual impairment, heart rhythm disturbances, arrhythmia of the “Torsades de pointes” type, hypertensive encephalopathy, decreased testosterone levels, muscle weakness, myopathy, rhabdomyolysis, myoglobinuria, acute renal failure.

Skipping the next dose of the drug

If one or more doses are missed, the drug should be resumed as usual without doubling the dose.

Side effect

Allergic reactions - skin rash, urticaria, itching, difficulty in nasal breathing, conjunctivitis, angioedema, anaphylactic type reactions.

From the sidegastrointestinal tract: rarely - dry mouth, diarrhea, constipation. With long-term use in high doses - dyspepsia, abdominal pain, nausea, vomiting.

Codelac is a long-known and effective drug From cough. It copes with any type of it, acts quickly and over a long period. The medicine is suitable for the treatment of children over 2 years of age, but in pediatrics it is used with caution due to the codeine contained in the composition.

Today, children are most often prescribed new forms of the drug Codelac with a safer composition and without codeine. For dry cough, “Neo” is used, and “Broncho” is used to remove phlegm. We reviewed them in this article.

Codelac has expectorant and analgesic properties.

Codelac Neo - combating non-productive cough

Active substance Codelac Neo products - butamirate. It reduces irritation of the bronchi and trachea, has a moderate anti-inflammatory and expectorant effect. Does not affect breathing and does not cause addiction. Used for obsessive non-productive (dry) cough in acute and chronic form.

It acts quickly - within an hour, and the effect lasts about 6 hours.

Release forms of Codelac Neo:

• drops (5 mg butamirate per 1 ml)- suitable for babies from 2 months;
• syrup (per 1 ml 1.5 mg of active ingredient)- prescribed for toddlers from 3 years old;
• tablets (50 mg of active substance per 1 piece)- used to treat children over 12 years of age.

The only contraindication for young patients is intolerance to the components of the medication. During treatment, side effects such as nausea, allergies, and drowsiness may occur. Judging by reviews from parents, the product rarely causes negative reactions in children. You can buy it without a doctor's prescription.

Syrup

The drug is sold in bottles of 100 and 200 ml. In addition to the medicine itself, each box contains instructions for use () and a double-sided measuring spoon. The product is a liquid with vanilla smell and sweet taste. In pharmacies, its average cost is 150 rubles (per 100 ml bottle).

Syrup taken before meals according to the regimen prescribed by the doctor. There is no need to dilute it. If the pediatrician does not recommend special instructions, give the child the drug according to the instructions - 3 times a day, no longer than five days.

• 3–6 years - a large measuring spoon, i.e. 5 ml (15 ml per day);
• 6–2 years - 2 large spoons, i.e. 10 ml (30 ml per day).

Natalya, Lisa's mother:

“The syrup is very sweet and tasty, children drink it with pleasure. I liked that the manufacturer provided a lid that Small child won't open. To unscrew it, you must first press and then unscrew it. Very comfortably! My daughter constantly climbs everywhere, and it’s difficult to hide something tasty from her. The medicine itself is inexpensive and effective; it quickly turns a dry cough into a wet one.”

Drops

In the cardboard box you will find instructions and a glass dropper bottle (20 ml) with the medicine. This form of release ensures the precise dosage required for treating the smallest children. Price - about 230 rubles.

Drops are prescribed to suppress attacks of dry cough.

You need to drink drops before meals 4 times a day. The dose is determined by the patient's age:

• from 2 months to a year - 10 drops (i.e. 40 drops per day);
• 1–3 years - single dose of 15 drops (60 per day);
• from 3 years - 25 drops (100 per day).

Contact your doctor if there is no improvement after 5 days of treatment.

Codelac Broncho with thyme - treat wet cough

Codelac Broncho - combination drug, eliminating the causes of sputum and facilitating its discharge. The complex effect of the product is due to the following components:

• glycyrrhizic acid - has antiviral and anti-inflammatory effects;
• ambroxol and soda (sodium bicarbonate)
• thyme extract (in children's elixir) - heals the bronchial mucosa damaged by cough and infection;
• thermopsis (in tablets) - has an expectorant effect.

Codelac broncho weakens the cough reflex and promotes the clearance of mucus from the respiratory tract.

Codelac Broncho is prescribed for respiratory diseases accompanied by the formation of sputum (bronchitis, COPD, pneumonia and others). Antitussive drugs hinder its action, so they are not used in parallel.

The medicine rarely causes allergies and other side effects. Prescribed with caution for renal and liver failure, stomach ulcers, bronchial asthma.

Codelac Broncho is considered the most effective remedy among analogues based on ambroxol, which is confirmed by positive reviews from patients. Available in the form of tablets (for children over 12 years old) and elixir (for children over 2 years old). A little more about him.

Elixir

It is a light brown liquid in a glass bottle with a volume of 50, 100 or 125 ml. The product comes with a measuring spoon (double-sided) and instructions. During storage, a sediment forms, which is eliminated after shaking the bottle. The approximate price of the elixir is 140 rubles (per 100 ml).

You need to take the medicine 3 times a day during meals.

The result is visible within 30 minutes after taking the medicine.

Dosage for children:

• 2–6 years - a small measuring spoon (2.5 ml each) at a time, i.e. 7.5 ml per day;
• 6–12 years - large measuring spoon (5 ml), 15 ml per day.

Duration of use - 5 days. A longer course is determined by the doctor.

Daria, mother of Vika and Sasha:

“When one child in a family gets a cold, the second one also gets sick. I prefer to buy drugs that are suitable for both my three-year-old daughter and my ten-year-old son. It's more practical and economical. This elixir clear instructions, a convenient spoon for dosing: on one side for babies, and on the other for older children. The taste is, of course, not for everyone, but it helps quickly. Within half an hour, phlegm is removed, and breathing is much easier. The drug is sold in almost every pharmacy, the price is affordable.”

What to replace the medicine with?

To treat dry cough in children, medications such as:

• and - analogues of Codelac Neo (for children) according to the active substance. Available in the form of drops and syrup, they have identical properties and contraindications.
• Bronholitin - effective, but not the most safe remedy, suitable for children from three years. Contains ethanol and has many contraindications.
• Glycodin - prescribed to children over 1 year old. Not suitable for patients with bronchial asthma and liver dysfunction.

Analogues of Codelac Broncho (expectorant):

• - reliable and safe drug for the youngest patients;

An analogue of the drug Codelac Broncho - Gedelix - syrup helps get rid of the reason why the child has a cough.

• - long known and effective remedy for children from 3 years old;
• - a medicine for children older than one year, contraindicated for peptic ulcers of the digestive system.

The components of each product can cause allergies in a child. If your baby has an individual intolerance to the drug, use a drug with another active substance. A doctor will help you choose it.

The range of cough medications is huge, and many of them are sold without a doctor's prescription. This does not mean that they are absolutely safe and can be used at the first manifestations of the disease.

The choice of remedy depends on the nature of the cough, accompanying symptoms, individual characteristics and the patient's age. Therefore, only a pediatrician can prescribe medications to a child.

PS: Just Codelac - differences between the adult version

The drug is produced in the form of yellow-brown tablets with inclusions. Its cost ranges from 140 to 300 rubles and depends on the pharmacy and region of sale. The product is produced by the domestic company Pharmstandard. Since 2003, this manufacturer has been developing and supplying affordable but high-quality products.

Codeine, which is part of the drug, belongs to the group of narcotic analgesics.

Medicine effective after 30 minutes(maximum hour) after application, the effect lasts 2–6 hours. The duration of treatment and dosage is determined by the doctor.

Lisa, Pasha's mother:

“I used to buy myself a simple Codelac for a cough. I know what is it strong drug with codeine, so I was very surprised when the pediatrician prescribed some kind of “Neo” for my son. It turned out that the names and manufacturer are the same, but the composition is completely different! The prescribed medicine helped quickly. The doctor said that it is safer than regular Codelac and does not contain codeine. When the dry cough went away, we switched to the Broncho version. This remedy removes phlegm. It turned out like this complex treatment. The child drank the syrups with pleasure, there were no side effects or allergies.”

Codelac weakens nonproductive cough, caused by any bronchopulmonary disease. His effective action explained by the combined composition:

• sodium bicarbonate (soda)- reduces the viscosity of sputum;
• licorice- has an antispasmodic effect;
• thermopsis grass- accelerates the removal of sputum, stimulates the respiratory center;
• codeine- a narcotic analgesic, has an effect on the cough center, reducing the manifestation of the symptom, regardless of its cause.

With prolonged use, the drug causes addiction.

Overdose threatens severe side effects: depression of the respiratory system, effect on peristalsis, loss of coordination, headache and others unpleasant symptoms. For these reasons, since 2012, over-the-counter sales of drugs containing codeine have been prohibited in Russia. Due to its composition, Codelac is prescribed to children only in extreme cases.

Anastasia Vorobyova

ABON BIOPHARM (Hangzhou) Co.,LTD I.D.T. Biology GmbH BIOLIT, LLC K.O. Biotechnos S.A. THFZ ICN Pharmstandard, LLC Pharmstandard-Leksredstva OJSC Pharmstandard-Tomskkhimpharm, OJSC Pharmstandard-Ufa Vitamin Plant, OJSC

Country of origin

Russia

Product group

Respiratory system

A drug with mucolytic, expectorant and anti-inflammatory effects

Release forms

• 10 - contour cell packaging (1) - cardboard packs. 10 - cellular contour packaging (2) - cardboard packs 10 - cellular contour packaging (1) - cardboard packs. 10 - contour cell packaging (2) - cardboard packs. 10 pieces. - contour cellular packaging (1) - cardboard packs. 100 ml - dark glass bottles (1) complete with a measuring spoon - cardboard packs. 50 ml - dark glass bottles (1) complete with a measuring spoon - cardboard packs. 100 ml - dark glass bottles (1) complete with a measuring spoon - cardboard packs. 125 ml - dark glass bottles, 100 ml bottles 20 ml dropper bottles made of dark (amber) glass. One bottle along with instructions for use in a cardboard box. 200 ml bottle, 50 ml individual/pack bottle, 200 ml individual/pack bottle with measuring spoon.

Description of the dosage form

• drops for oral administration. colorless liquid with a vanilla odor. gel Gel with essential oils of coniferous trees, liquid from light brown to brown color. During storage, sediment may form. The syrup is brown in color, with a characteristic aromatic odor. Tablets are yellow to brown with white to dark brown flecks. Tablets from light cream to cream with a yellowish tint with darker and lighter inclusions, flat-cylindrical, scored and chamfered. Modified-release film-coated tablets white, round, biconvex; on cross section tablets are white or almost white.

pharmachologic effect

Thanks to the balanced composition of biologically active substances, KODELAK® PULMO gel: - helps improve blood supply to the tissues of the bronchopulmonary system; -has a locally irritating, “distracting” effect; -promotes the removal of sputum and reduces stagnation in the bronchopulmonary system, thereby relieving cough; -stimulates protective functions body and can be used in case of hypothermia as a means for preventive restorative massage. The components of the gel have anti-inflammatory and bactericidal effects, and have a beneficial effect on the respiratory tract due to the sufficiently high concentration of vapors of essential oils and other gel components in the inhaled air (aromatherapy). This makes it possible to use CODELAC® PULMO gel for acute respiratory infections and other respiratory diseases, including to relieve cough and improve sputum discharge. KODELAK® PULMO contains natural ingredients obtained from coniferous plants growing in ecologically clean areas of Siberia. The properties of CODELAC® PULMO gel are due to the complementary action of its constituent components. Fir oil has a complex effect due to the content of a large number of biologically active compounds that determine its anti-inflammatory, antiseptic, tonic and blood circulation-improving effects. Fir oil has a local irritant effect, helps improve microcirculation, its constituents essential oils capable of exerting a bactericidal effect. Thanks to its complex anti-inflammatory and bactericidal effect, fir oil is used for diseases of the upper respiratory tract and acute respiratory infections. Camphor, influencing the nerve endings of the skin, causes reflex expansion blood vessels and blood flow to the area of ​​application, as well as to the tissues of the bronchi and lungs, improving their nutrition and oxygen saturation, facilitating the discharge of sputum. These properties of camphor determine its locally irritating, distracting, local analgesic, anti-inflammatory and moderate expectorant effect. In addition, camphor also has an antiseptic effect. Camphor is widely used for colds and inflammatory diseases, including to relieve cough and improve sputum discharge. Turpentine has a “distracting”, analgesic and antiseptic effect, therefore it is used in a number of ointments, including initial stages upper respiratory tract diseases.

Pharmacokinetics

Absorption After oral administration, butamirate is quickly and completely absorbed from the gastrointestinal tract. After taking 150 mg of butamirate, the maximum concentration of the main metabolite (2-phenylbutyric acid) in the blood plasma is reached after approximately 1.5 hours and is 6.4 mcg/ml. Distribution and metabolism Hydrolysis of butamirate initially to 2-phenylbutyric acid and diethylamino-ethoxyethanol begins in the blood. These metabolites also have antitussive activity, and, like butamirate, are largely (about 95%) bound to plasma proteins, which causes their a long period half-life. 2-phenylbutyric acid is partially metabolized by hydroxylation. At readmission no drug accumulation is observed. Elimination The half-life of butamirate is 6 hours. Metabolites are excreted mainly by the kidneys. Moreover, 2-phenylbutyric acid is mainly excreted in the form associated with glucuronic acid.

Special conditions

* prolonged treatment with high doses can lead to dependence on the drug; * Codelac phyto should not be prescribed simultaneously with mucolytic and expectorant drugs; * before prescribing antitussives, the cause of the cough should be clarified due to the possible need for special treatment; * due to the possibility of developing a sedative effect, during treatment it is not recommended to engage in activities that require increased attention, speed of mental and motor reactions; * athletes should remember that the drug contains codeine and is a doping agent; * caution must be exercised in case of increased intracranial pressure; * in patients with impaired renal function, codeine excretion is slow, so it is recommended to lengthen the intervals between doses of the drug; * Drinking alcoholic beverages is prohibited while taking Codelac® phyto.

Compound

• 1 tab. butamirate citrate 50 mg Excipients: lactose monohydrate - 241 mg, hypromellose - 85 mg, talc - 4 mg, magnesium stearate - 4 mg, colloidal silicon dioxide 6 mg, low molecular weight povidone 5 mg. ambroxol hydrochloride 10 mg sodium glycyrrhizinate 30 mg liquid thyme extract 500 mg Excipients: methyl parahydroxybenzoate (nipagin), propyl parahydroxybenzoate (nipazole), sorbitol (sorbitol), purified water. ambroxol hydrochloride 20 mg sodium glycyrrhizinate 30 mg dry thermopsis extract 10 mg sodium bicarbonate 200 mg Excipients: potato starch, microcrystalline cellulose, povidone K25 (kollidon K25), talc, stearic acid, sodium carboxymethyl starch (sodium starch glycolate, Primodel). butamirate citrate (in terms of 100% substance) – 100 mg; Excipients: sorbitol (Neosorb 70/70 B, sorbitol syrup) 8100 mg, glycerol (glycerol) 5800 mg, ethanol 96% ( ethanol) 60 mg, sodium saccharinate 23 mg, benzoic acid 23 mg, vanillin 23 mg, sodium hydroxide solution 30% (sodium hydroxide) 10 mg, purified water up to 20 ml. water, fir oil, glycerin, racemic camphor, vegetable oil, red pepper extract, PEG 400 aristoflex, vinylin. codeine phosphate 4.5 mg dry thermopsis extract 10 mg thick licorice root extract 200 mg liquid thyme extract 1 g Excipients: sorbitol, nipagin, nipazole, water. per 5 ml: Active substance: butamirate citrate - 7.5 mg; Excipients: sorbitol (Neosorb 70/70, sorbitol syrup) 2025.0 mg, glycerol (glycerol) 1450.0 mg, ethanol 96% (ethyl alcohol) 12.5 mg, sodium saccharinate 3.0 mg, benzoic acid 5, 75 mg, vanillin 3.0 mg, sodium hydroxide solution 30% (sodium hydroxide) 1.55 mg, purified water up to 5 ml.

Codelac indications for use

• to eliminate dry cough in children from 2 months; Dry cough of any etiology, including whooping cough; to suppress cough in the preoperative and postoperative period, at surgical interventions and bronchoscopy.

Codelac contraindications

• - pregnancy; - lactation period (breastfeeding); - children under 2 years of age; - hypersensitivity to the components of the drug. The drug should be used with caution in patients with hepatic and/or renal failure, peptic ulcer stomach and duodenum, bronchial asthma.

Codelac dosage

• 1.5 mg/ml 5 mg/ml

Codelac side effects

• From the side of the central nervous system: rarely - weakness, headache. From the outside digestive system: rarely - diarrhea, dry mouth, constipation; with long-term use in high doses - gastralgia, nausea, vomiting. From the outside respiratory system: rarely - dryness of the mucous membrane of the respiratory tract, rhinorrhea. Other: rarely - dysuria, exanthema, allergic reactions.

Drug interactions

It is undesirable to use it with other drugs that depress the activity of the central nervous system, due to the increased sedative effect and inhibitory effect on the respiratory center: sleeping pills, sedatives, antihistamines, narcotic analgesics, morphine derivatives, anxiolytics, antipsychotic drugs. Codeine enhances the effect of ethanol on psychomotor function. Chloramphenicol inhibits the biotransformation of codeine in the liver and thereby enhances its effect. When codeine is used in large doses, the effect of cardiac glycosides (digoxin, etc.) may be enhanced, since their absorption increases due to the weakening of peristalsis. Adsorbents, astringents and coating agents can reduce the absorption of codeine, which is part of the drug, in the gastrointestinal tract.

Overdose

Symptoms: drowsiness, vomiting, headache, itching, miosis, depression of the respiratory center, bradypnea, arrhythmias, bradycardia, urinary retention, bladder atony. Treatment is symptomatic, including restoration of breathing and cardiovascular activity, gastric lavage

Storage conditions

• store in a dry place
• keep away from children
• store in a place protected from light

Information provided

Codelac – medicine with an antitussive effect, in addition, the drug promotes better discharge bronchial secretion, that is, it has an expectorant effect.

What are the composition and release form of Codelac tablets?

The pharmaceutical industry produces a drug in tablets, they may have different colors, varying from brown to yellow, normally there may be splashes of white or dark brown.

The tablets contain the following active ingredients: codeine, added sodium bicarbonate, in addition, powder prepared from licorice root and thermopsis lanceolate herb. Among the auxiliary compounds we can note: potato starch, as well as talc and microcrystalline cellulose.

The medicine is sold in contour packages. You can buy it without a prescription. The shelf life of the medicine is four years from the date of pharmaceutical production of the tablets. Codelac should be stored at a temperature of no more than 25 degrees.

What is the effect of Codelac?

The drug Codelac has a combined composition. Codeine has a central antitussive effect and helps reduce the excitability of the cough center. When used in excessive doses, it can depress breathing and also inhibits peristaltic movements of the intestines, in addition, it causes miosis, sometimes constipation, nausea and vomiting. This active ingredient may provoke drug dependence.

The next active compound of the drug Codelac is thermopsis herb; it contains isoquinoline alkaloids, which have a stimulating effect on the respiratory center and also stimulate the vomiting center. This representative of the flora has a pronounced expectorant effect, as a result, the secretory function of the bronchial glands increases, in addition, the activity of the so-called ciliated epithelium increases, and in general the evacuation of secretions is accelerated.

Another component of Codelac is sodium bicarbonate; it is capable of changing the pH of mucus, which is localized in the bronchi, changing it to the alkaline side. In addition, this substance reduces the excessive viscosity of sputum, and also stimulates the motor function of the so-called ciliated epithelium.

Licorice root, which is also present in the drug Codelac, has an expectorant effect on the body due to the glycyrrhizin present in the plant, it activates the ciliated epithelium that lines the trachea and bronchi, and also strengthens secretory function mucous membranes of the respiratory tract.

In addition to the listed properties, licorice root has an antispasmodic effect on the body, in particular on smooth muscles, this is due to the flavone compounds present in this plant.

The drug promotes high-quality evacuation of mucus directly from the respiratory tract when the patient has a severe cough, in addition, the drug weakens the cough reflex. About thirty minutes or one hour after taking the tablets, the maximum effect of the medication occurs.

What are the indications for use of Codelac?

The drug Codelac is prescribed as symptomatic treatment if you have a dry cough of various origins arising against the background of bronchopulmonary diseases.

What are the contraindications for use of the medicine Codelac?

The instructions for use prohibit the use of the drug Codelac (tablets) in the following cases:

At respiratory failure;
At breastfeeding;
Up to two years of age;
For bronchial asthma;
Do not use the medicine during pregnancy;
Codelac should not be used together with analgesics. central action, for example, with buprenorphine and nalbuphine.

It is contraindicated to take the drug together with alcohol; in addition, Codelac is not used for hypersensitivity to the components of this medication.

What are the uses and dosages of Codelac tablets?

The drug Codelac is prescribed orally, one tablet up to three times a day. Therapeutic measures should not last long. It is worth knowing that the maximum dose of codeine per day should not exceed 200 mg, and a single dose should not exceed 50 mg.

Overdose from Codelac

In case of an overdose of Codelac, the patient will develop following symptoms: arrhythmia, drowsiness, vomiting, skin itching, possible nystagmus, bradycardia, in addition, atony of the bladder.

In such a situation, the patient undergoes urgent gastric lavage, symptomatic treatment is prescribed, and administration is also indicated, which is an antagonist of codeine. If necessary, the patient is hospitalized in a hospital.

What are the side effects of Codelac?

Codelac may cause the following: side effects: possible nausea, drowsiness, vomiting, constipation, possible headache, itching, and urticaria. With prolonged use of the medication, the patient may develop a drug dependence directly to codeine.

special instructions

With great caution, Codelac tablets instructions for use and doctors prescribe to patients with increased intracranial pressure. In case of kidney pathology, the removal of the drug from the body may be somewhat slower, therefore, it is necessary to increase the interval between taking the tablets.

How to replace Codelac, what analogues should I use?

Currently, no analogues have been developed.

Conclusion

Before taking Codelac tablets, the patient should consult with a qualified healthcare professional.

The patient must independently study the instructions for use of the prescribed drug. Be healthy!