Which is better heptral or rezalyut. Liver tablets: list of effective hepatoprotectors

Updated: 03/23/2020

The liver is the largest gland. Takes part in digestion and neutralization of harmful substances. Responsible for the production of bilirubin, cholesterol, enzymes and hormones. Capable of storing blood and glucose. Any disturbances in the functioning of the organ are manifested by poor health.

Characteristic signs of a malfunction are bloating, pain, poor digestion. May harm the liver junk food, poor environmental conditions, management unhealthy image life. If you need treatment or want to carry out prevention, check out the rating the best drugs for the liver. You will learn the opinions of customers and experienced professionals. Before taking, be sure to consult your doctor.

Essential phospholipids

Pharmaceutical companies offer several medications containing polyunsaturated (essential) fatty acids. The components have metabolic and hepatoprotective properties. They are used to treat liver diseases.

Designed to restore organ structure in case of hepatitis, fatty degeneration and cirrhosis. Manufacturers also claim that phospholipids have additional properties: they improve metabolism, reduce the likelihood of developing atherosclerosis, improve skin condition, and help after radiation.

Advantages

• Drugs for liver restoration are well tolerated by patients.
• Reduce the likelihood of disease recurrence.
• They help as a complex drug in the treatment of hepatitis C.
• Easy to digest.
• Prescribed even during pregnancy.
• Reduce liver costs.
• Improves enzyme activity and physicochemical parameters of bile.

Flaws

• Pain may occur after an intravenous injection.
• They do not restore liver cells, but only cell walls.
• For maximum results, the course of treatment should be at least 6 months.
• Do not take simultaneously with medications containing vitamin B.
• They can activate the inflammatory process.
• High price.

Rating of the best essential phospholipids

Hepatoprotector. A complex of vitamins, amino acids, essential phospholipids and plant extracts that protect and support liver cells, and also help restore already damaged liver structure (including after hepatitis).

Helps the body as a whole in the fight against harmful factors (alcohol, heavy metals, poisoning, poor diet, etc.) and diseases.

Capsules (90 pcs.).

• Provides 4-component comprehensive liver protection
• Helps gently cleanse the liver of toxins
• Protects the liver from adverse factors
• Promotes natural regeneration of liver cells
• Improves metabolism and restores liver function
• The components of the composition have been well studied and have a favorable safety profile.

• Not available for sale in all regions
• Contraindications: pregnancy, breastfeeding, individual intolerance to the components.

Hepatoprotective, antiviral agent with a combined composition. Contains simultaneously two active components - phospholipids and glycyrrhizic acid.

Has a regenerative effect. Restores the functions and structure of membranes.

It also has cytoprotective properties. Normalizes protein and lipid metabolism.

Produced in capsules for oral use. The best effect is achieved when taking the drug with food.

Prescribed when viral hepatitis(both chronic and acute forms), toxic damage and cirrhosis of the liver. As an auxiliary component it can be used in the treatment of neurodermatitis, intoxication, psoriasis, eczema.

• Prevents loss of enzymes.
• Stimulates liver function.
• Promotes the formation connective tissue.
• Reduces the risk of cirrhosis and fibrosis.
• Well tolerated by the body.
• Contains plant components.
• Cheaper than analogues.
• Increases the body's protective function.
• Eliminates pain in the right hypochondrium.
• Small capsules.

• There are side effects.
• Increases blood pressure.
• Duration of treatment.

Dietary supplement helps replenish the body's need for vitamin E and essential phospholipids. This improves the state of the antioxidant system and normalizes liver function.

Metabolism is optimized. The drug protects cell membranes from oxidation.

Supports the functioning of the nervous system. Gepagard is also prescribed for low body resistance to toxins.

To achieve a therapeutic effect, you must take two capsules with meals. During the day you need to drink the dietary supplement 2 times.

The course of treatment is one month.

• Accelerates cell regeneration.
• Improves metabolism.
• Normalizes the functioning of the digestive tract.
• Improves memory.
• Normalizes the conductivity of impulses.
• Safe composition.
• Affordable price.
• Easy to take.

• A small number of capsules in one package.

One of the effective hepatoprotectors. Has a combined effect.

Contains essential phospholipids and milk thistle. One capsule of the drug contains seventy milligrams of silymar and from one hundred to two hundred milligrams of lipoid.

It also contains additional components. One package contains 30 light orange capsules.

Normalizes the exchange of proteins, phospholipids and lipids. Helps digest food and activates the production of enzymes.

Stabilizes cell membranes. Protects cells from destruction.

Accelerates regeneration and excretion of bile. Prevents the formation of connective tissue.

• Removes toxins from the body.
• Has antioxidant properties.
• There are practically no contraindications and side effects.
• Protects tissues from toxic damage.
• Restores the structure and functions of the liver.

• During the day you need to take about 6 capsules.
• High cost of the drug.

The drug was created to prevent acute liver diseases. It also stops the progression of existing chronic ailments.

Helps to lead a healthy lifestyle in case of chronic hepatitis and cirrhosis. Regulates carbohydrate and fat balance.

Has a detoxifying effect. Like other hepatoprotectors, it is prescribed in combination to eliminate organ damage.

Contains fat metabolism products and B vitamins, including pyridoxine hydrochloride, riboflavin, cyanocobalamin, thiamine mononitrate. Helps the body cope with heavy foods - broths, mayonnaise, fatty and fried foods, cakes with cream and alcohol.

• Helps remove toxins and waste.
• Affordable price compared to foreign analogues.
• Improves blood counts. Proven by ALT test results.
• Supports the body during a diet.
• Can be taken by children.
• It helps within a few days after the first use.

• Fragile capsules.
• Not produced in ampoules.
• There are contraindications.
• May cause side effects.
• To consolidate the result you need to take it for several months.

The drugs are created for the prevention and treatment of the liver. Capable of changing the cellular structure of an organ.

They improve the density of membranes and also restore their functionality. Can relieve severe symptoms of the disease within a short time, improve well-being.

The composition includes linoleic and linolenic acid. One package contains 30 capsules.

Each of which contains 6 milligrams of thiamine, 3 thousand milligrams of essential phospholipids and 6 milligrams of riboflavin.

In addition to these active substances, there are also auxiliary components. .

• Contains no vitamins. The therapeutic effect is provided by hepatoprotectors.
• Unlike classic multivitamin complexes, the drug can be taken for a long time without harm to health.
• Has a detoxifying effect.
• Relieves cirrhosis of the liver.
• Safe composition.
• Slows down the inflammatory process and reduces the degree of tissue necrosis.
• Improves general state digestive tract and overall health.
• Available without a prescription.
• Can be bought at any pharmacy.
• Suitable for treatment during pregnancy.

• For a stable and long-lasting effect, you need to take the drug for 3 to 12 months.
• Not prescribed for children.
• Contraindicated in case of individual intolerance to phosphatidylcholine.

Rating of the best solutions of low molecular sugars

The drug is designed to provide comprehensive support for liver function. Heptrong has an antioxidant effect; it contains low molecular weight sugars obtained from natural product beekeeping - honey.

The active components protect the organ and reduce the cellular permeability of its tissues. This hepatoprotector is indicated for use by people suffering from liver damage of various origins: alcoholic, medicinal and other toxic.

• works as an antioxidant
• allowed for pregnant women
• can be taken for any severity of the problem
• reduces the intensity of inflammation
• completely decomposes to water and carbon dioxide
• well tolerated, without pain at injection sites

• Injection form only
• Not suitable for people with allergies to bee stings, honey and other honey derivatives

The main purpose of the drug is to restore the functioning of the liver, for which it is an antispasmodic and choleretic agent. Its effect is noticeable even with serious pathologies, for example, cirrhosis of the liver.

In addition, Heptral has a sedative and antidepressant effect on the patient, which is necessary in the acute phase of the disease. The medicine is also effective for certain brain pathologies.

The effect of the drug is associated with its accumulation in the body. Therefore, you should not expect a quick effect that occurs immediately after taking it.

• Indications for use:
• Cholangitis (infectious inflammation bile ducts).
• Fatty liver degeneration.
• Cirrhosis of the liver.
• Chronic hepatitis.
• Withdrawal syndrome, including alcoholic.

• May cause headaches, dizziness, and confusion.
• Possible side effects - increased sweating, rash, itching, allergic reactions
• Can cause muscle spasms and joint pain.

The drug has a hepatoprotective effect and accelerates the transition of anaerobic processes to aerobic ones. Its intake improves the energy supply of hepatocytes, restores the activity of antioxidant enzymes, and increases the resistance of hepatocyte membranes to lipid peroxidation.

• Indications for use:
• Alcoholic hepatitis
• Toxic hepatitis
• Drug-induced hepatitis.
• Functional liver disorders associated with acute or chronic diseases

• Possible metabolic disorders associated with activation of aerobic processes (
• Unpleasant sensations when administering the drug
• Allergic reactions are possible (rash, itchy skin).
• Possible nausea headache, dizziness.

Herbal preparations for the liver

According to experts, the best herbal medicines contain milk thistle. These include “Karsil”, “Legalon”, “Silimar”, “Gepabene”, “Sibektan”. The main active ingredient of such drugs is silymarin. Combines three compounds - silydianin, silicristin and silibinin.

It has antioxidant and membrane-stabilizing properties. Counteracts liver stress (oxidative). Has an immunomodulatory effect. Protects the organ from alcohol disease. With prolonged use - about six months, the number of cytotoxic lymphocytes and the production of gamma globulin decreases. Minimizes cell susceptibility to toxic substances.

Advantages

• Natural composition.
• Promote cell regeneration.
• Stimulate protein synthesis.
• They have a choleretic effect.
• Increases the secretion of bile acids.
• Eliminate spasm of the bile ducts.
• Can be used for prevention.
• They have a strong antioxidant effect.

Flaws

• Manufacturers, in addition to milk thistle, may use other, less safe components.
• The course of treatment is usually at least 3 months.
• The effectiveness of drugs during the treatment of acute hepatitis or alcoholic impairment has not been clinically proven.

Rating of the best drugs for the liver of plant origin

The drug contains extracts of St. John's wort, common tansy and milk thistle. Helps in the treatment of alcoholic fatty liver disease, alcoholic liver disease, alcoholic cirrhosis of the liver, chronic cholecystitis and chronic persistent hepatitis.

It has hepatoprotective, membrane-stabilizing, antioxidant and choleretic effects. Has a mild effect.

Doctors also prescribe the drug in combination with others to restore liver cell membranes and have a better antioxidant effect. "Sibektan" also additionally has a tonic property.

Relieves depression, improves the functioning of the digestive tract. Clinically proven anti-inflammatory and antibacterial properties.

For maximum effectiveness, take on an empty stomach half an hour before meals. The daily dose should not exceed 800 milligrams.

The standard course of treatment is 20 weeks. According to the doctor's decision, it will need to be repeated after 2 or 3 weeks.

• Has a complex effect. May help with peptic ulcer, gastritis or kidney disease.
• Does not cause overdose.
• Safe composition.
• Various release forms.

• You need to take a lot of pills throughout the day. We'll have to get used to the new regime.
• There are contraindications.
• Not prescribed under 18 years of age.

The medicinal product contains herbal components. It has antitoxic and hepatoprotective properties.

Developed for the treatment of liver cirrhosis, toxic damage to the organ, as well as for recovery from hepatitis. Prescribed as a prophylaxis for intoxication in chronic form.

With prolonged use of medications and alcohol abuse. The medicine should be taken before meals, half an hour.

The standard dosage includes one or two liver recovery tablets three times a day. The course of therapy, depending on the severity of the disease, is 25-30 days.

To prevent relapse of a chronic disease, a repeated course of treatment will be required at intervals of one to three months.

• Contains components of plant origin.
• Has antitoxic and hepatoprotective effects.
• Slows down the penetration of toxins into cells.
• Stimulates regeneration.
• Fast effective action.
• Affordable price.
• Relieves painful sensations.
• Can be used in combination with other drugs.

Complex preparation with herbal components. Contains fume extract, milk thistle fruit.

Has a choleretic effect. It also normalizes the amount of its production and reduces sphincter tone.

Has a hepatoprotective effect. Protects liver cells from alcohol and toxins.

Stimulates the restoration of hepatocytes and protein synthesis. Suitable for the treatment of liver diseases various stages– acute and chronic.

For maximum effect, take after meals. The standard dosage for adults is one capsule three times daily.

To remove severe pain Your doctor may prescribe an additional dose before bed. The product is produced in hard capsules.

There are thirty pieces in a package.

• Natural composition.
• Quick effect.
• Removes severe pain.
• Improves the functioning of the digestive tract.
• Relieves heaviness.
• Affordable price.
• After use, constant nausea disappears.

• Do not take if you have an individual intolerance to one of the active ingredients.
• Not prescribed for acute inflammatory processes of the liver and biliary tract.
• Should be taken with caution during pregnancy and breastfeeding.
• Inconvenient release form - large capsules.
• Laxative effect.

Refers to herbal medicines. Prescribed for gastrointestinal diseases and severe pathological conditions of the liver.

Contains flavonoid isomeric compounds. Produced in the form of dragees, capsules and suspensions.

The main active ingredient is isolated from milk thistle. The drug has hepatoprotective and antitoxic effects.

Normalizes physical and chemical parameters. Slows down the penetration of toxic components into liver cells.

Accelerates the regeneration of organ cells. Prescribed for damage by several medications - Paracetamol, antidepressants, antibiotics, after anesthesia, immunosuppressants and psychotropics.

• Relieves itchy skin and vomiting.
• Eliminates heaviness in the right hypochondrium.
• Restores appetite.
• Improves general condition.
• According to the test results, bilirubin, transaminases, and alkaline phosphatase activity decrease.
• Contains natural ingredients.

• High price.
• May cause diarrhea.
• Contains dyes.

The drugs belong to the hepatoprotector group - herbal drugs. Silymarin is used as the main active ingredient.

It is obtained from the fruit of milk thistle. Produced by the Bulgarian company Sopharma.

The drug with the prefix “forte” has a high concentration of the active substance. The classic drug is produced in the form of brown dragees.

There are 80 pieces in one package. Karsil Forte contains 30 gelatin capsules.

Has a specific smell. Prescribed for toxic liver damage as a result of long-term treatment, for chronic and alcohol intoxication, cirrhosis, steatosis, for recovery after acute hepatitis.

• Has a stabilizing effect.
• Normalizes fat metabolism.
• Stimulates the production of phospholipids.
• Protects liver cells from negative impact toxins.
• Restores hepatocytes.
• Slows down fatty degeneration of the organ and the development of fibrosis.
• Has an antioxidant effect.
• Normalizes blood microcirculation.
• Improves general condition, including increasing appetite.

Liver tablets – bile acids

Ursodeoxycholic acid (UDCA) is the only one of its kind that does not harm the human body. Refers to bile acid agents. Prescribed for the treatment of diseases of the liver and biliary tract, cholelithiasis(not complicated type).

Do not take if there is a high calcium content of gallstones. Has hypoglycemic properties. Increases gastric and pancreatic secretion. Able to change the immunological reaction of the liver. You should not take the drug without a doctor's prescription. There are very serious contraindications.

Advantages

• Reduces the number of eosinophils.
• In combination with other drugs, it will help dissolve cholesterol formations in gallbladder.
• Will help with toxic, alcoholic liver damage.
• Can be used by pregnant women to treat hepatopathy.
• One of the most effective means for the treatment of sclerosing cholangitis (primary type) and biliary cirrhosis.
• Prescribed to the most vulnerable category of patients - in adolescence, pregnancy. And also for the treatment of hemophilia, substance abuse and drug addiction.

Flaws

• There are many drugs with unconfirmed quality.
• They can cause harm in case of inflammation of the gallbladder, intestines, dysfunction of the kidneys, pancreas, and liver.
• Individual intolerance often appears.

Rating of the best bile acid drugs for liver treatment

Rating	#1	#2	#3
Name

Hepatoprotector with cholelitic, choleretic, hypocholesterolemic, and immunomodulatory effects. Increases the protection of liver cells from bile acids.

Changes their structure. Improves the production and excretion of bile.

Destroys gallstones and protects the liver from harmful effects alcohol. Ursodeoxycholic acid in the drug prevents cholestatic liver diseases.

Produced in the form of milky gelatin capsules. The number of capsules, as well as the duration of administration, depends on the disease and body weight.

Prescribed for biliary cirrhosis at the stage of compensation of the primary type, for biliary reflux gastritis, medium and small cholesterol stones. Intended for oral use.

• Reduces cholesterol production.
• Minimizes bile lithogenicity.
• Destroys cholesterol stones.
• Replaces toxic bile acids with non-toxic ones.
• Improves the secretion of liver cells.
• Improves immunoregulatory processes in the body.
• Copes with stagnation of bile.

• The drug is not prescribed to children.
• Long-term use will require significant costs.
• Causes side effects - nausea, vomiting, constipation, diarrhea.

An effective hepatoprotective drug with a choleretic effect. Reduces the concentration of cholesterol in the blood and its further absorption in the intestines.

Promotes the formation and secretion of bile. Strengthens pancreatic and gastric secretion.

Has hypoglycemic properties. When administered enterally, it partially or completely dissolves cholesterol stones.

Helps remove organic compounds from gallstones. Has an immunomodulatory effect.

The main active ingredient is ursodeoxycholic acid. The dosage, as well as the duration of treatment, depends on the disease.

To dissolve gallstones, you will need to take Ursodez at the rate of ten milligrams of the active ingredient per kilogram of body weight. The optimal time for use is before bed.

Capsules must not be chewed. It is important to drink a small amount of water.

• Can be taken for a long time - up to 24 months.
• It is very easy to assess the effectiveness of the drug using ultrasound or radiography.
• Effective treatment.
• Has a complex effect.
• Convenient release form.
• Small capsule size.
• Minimal side effects.

The hepatoprotector is produced in the form of gelatin capsules white. Packaged in plastic bottles or blisters.

Has a choleretic effect. Prevents the formation of stones.

Displays existing stones. Effectively affects the composition of bile, the functioning of the pancreas and stomach.

Activates the functions of liver cells. Increases the body's protective functions.

Absorbed into small intestine. The maximum concentration is observed in the blood two hours after administration.

Then binds to plasma proteins. As a result of prolonged use, it is converted into basic bile acid.

Located in blood serum.

• Cholesterol secretion decreases.
• Toxins are removed from the body faster.
• The functioning of the pancreas and stomach improves.
• Lipase activity increases.
• Blood sugar levels drop.
• Convenient packaging.
• It works effectively. The dynamics can be tracked based on the analysis results.
• Affordable price.

• It is forbidden to take the drug in case of calcified stones, obstruction of the bile ducts, acute inflammatory processes, hepatic colic, or if you weigh less than 34 kg.
• Causes nausea, vomiting, pain, diarrhea or constipation.
• Capable of calcifying gallstones.
• Exacerbates psoriasis.
• Leads to hair loss from the scalp.

Contains ursodeoxycholic acid. Prescribed in the treatment of diseases of the digestive tract.

The main active ingredient reduces cholesterol synthesis. Due to this, the concentration in the intestines increases.

The drug has a particularly effective effect when the disease is not advanced. Doctors recommend taking the medicine in the evening.

It is enough to take the capsules with plenty of water. In the first days of taking it, you need to monitor the level of liver enzymes.

• The drug replaces harmful bile acids (with toxins) with non-toxic UDCA.
• Stimulates the body's protective functions.
• Improves the secretory properties of liver cells.
• Ursosan quickly breaks down and is eliminated from the body.
• Painlessly dissolves stones.
• Relieves the condition of gastritis.
• Wide spectrum of action.
• Safe composition.
• Eliminates colic in the right hypochondrium.
• Reduces cholesterol levels.
• Helps against jaundice in newborns.

• Not prescribed if the diameter of the stones exceeds 15 mm.
• It may not help with primary type biliary cirrhosis of the liver, even with prolonged use - from 6 to 24 months.
• There are contraindications. Do not take for acute inflammation of the gallbladder and gallstones, colic, or obstruction.
• Causes side effects.
• Prescribe with caution for hepatitis and cirrhosis of the liver.
• As a standard, the drug is allowed to be given to children from 5 years of age. But the age threshold can be changed by the doctor’s decision.
• Exceeding the dosage specified in the instructions causes distress. You need to stop the drug and consult a doctor. It is necessary to restore the water-salt balance in the body.

Has a choleretic effect. Destroys cholesterol stones.

Prevents the proliferation of connective tissue after damage to liver cells. Contains ursodeoxycholic acid.

The substance forms mixed type micelles. Protects membranes from damage.

Increases the content of bile acids. Which, in turn, promotes the dissolution of cholesterol gallstones.

Strengthens the secretion of the pancreas and stomach. It also has an immunological effect.

Regulates the number of immune cells. It stops fibrosis in cases of primary biliary cirrhosis, cystic fibrosis, and also in cases of alcoholic liver damage.

Reduces the likelihood varicose veins veins in the esophagus. As a result of research, the effectiveness of Ursofalk in delaying the development of tumor tissues has been proven.

Therefore, it is prescribed in combination with other drugs for the treatment of colon cancer. Produced in the form of suspension and capsules.

• There are no age restrictions.
• Reduces bilirubin. It is even prescribed to newborns.
• Can be used in combination with other drugs and herbal decoctions.
• Dissolves gallstones.
• Eliminates bending of the gallbladder.
• Has a choleretic effect.
• Eliminates allergic reactions.
• Can be used during pregnancy. Prescribed for hypatosis.
• Relieves nausea and itching.

Liver tablets of animal origin

There are only a few such drugs. They are usually not prescribed as prophylaxis. Suitable for the treatment of liver diseases for several reasons - hepatitis, cirrhosis, fatty liver hepatosis, toxic and drug-induced hepatitis. For production, depending on the preparation, pig liver cells, large liver hydrolyzate are used. cattle, cyanocobalamin, amino acids, liver growth factor segments and low molecular weight metabolites. Also pharmaceutical companies produce drugs with combined effects.

Advantages

• Capable of restoring cell structure.
• Improve blood flow.
• Changes the functional parameters of the liver.
• After administration, diuresis usually increases.
• Can be used in combination with other drugs for the treatment of cirrhosis, chronic hepatitis, radiation sickness, fatty degeneration, and drug intoxication.

Flaws

• There is no official confirmation of the clinical safety and effectiveness of the drugs.
• Particular caution should be taken when taking the medicine during the acute stage of hepatitis. There is a possibility of aggravation of the inflammatory, immunopathological, cytological syndrome.
• Causes a serious allergic reaction. Before starting treatment, you need to check for hypersensitivity to the components of the drug.
• Cattle liver hydrolysates can cause prion infection. The latter, in turn, causes Creutzfeldt-Jakob disease (a dangerous neurodegenerative disease).
• It is not recommended to take it as a prophylaxis.

Rating of the best drugs for the liver of animal origin

Rating	#1	#2	#3
Name

The drug contains both plant and animal components. Treatment effectiveness has been proven pathological condition hepatobiliary system.

The composition includes crushed nettle leaves, garlic powder, dry bile, Activated carbon. The components regulate metabolic processes in the intestinal wall.

Suppresses the development of helminths. Vitamins of group A, D, E, K promote absorption.

Has a detoxifying effect. Stimulates the emulsification of lipids in the gastrointestinal tract.

Speeds up metabolism. Removes them from the body.

Helps reduce flatulence and the growth of pathogenic microorganisms. The duration of treatment, as well as the dosage, depends on the disease.

• Improves the secretory function of liver cells.
• Stimulates the synthesis of bile acids.
• Accelerates the movement of bile along the bile ducts.
• Eliminates atonic constipation.
• Prevents infection.
• Reduces inflammation.
• The film coating of the drug protects the properties of Allochol.
• Can be combined with other medications.

• There are contraindications.
• May cause side effects such as diarrhea. Also known clinical cases allergic reaction.
• Exceeding the prescribed amount of the drug leads to an overdose.
• Do not take simultaneously with Cholestyramine, aluminum hydroxide and Cholestipol.

The drug was created to protect liver tissue. It also helps restore damaged functional and structural elements of the organ.

Normalizes hepatic blood flow. Increases urination.

Improves liver function. Prescribed for chronic hepatitis, hepatocardial syndrome, liver cirrhosis, toxic hepatitis, toxicosis of pregnancy, kwashiorkor and other disorders.

There are several forms of release. Dragees are suitable for oral use.

It is also produced in the form of a solution for intravenous and intramuscular injections.

• Fast action.
• Effectively restores the liver.
• Created on a biological basis.
• Helps with viral hepatitis.
• Helps with exhaustion of the body.

The liver bioregulator improves its functions. Restores after a course of treatment, poisoning or under the influence of other negative factors.

Available in tablet form. There are 40 pieces in one package.

Prescribed for the prevention and treatment of polyetiological diseases and other liver damage. Eliminates the consequences of toxic, infectious, metabolic, involutional and other influences.

The drug relieves chronic and acute liver failure. It has hepatotropic properties.

The composition includes nucleoproteins and proteins from cattle. Strengthens reparative processes in liver cells.

Restores their work. The functional-corrective and hepatoprotective effect of the drug has been clinically confirmed.

Prescribed depending on the complexity of the disease. The standard course of treatment is from 10 to 14 days.

Repeat therapy may be required after 3 or 6 months.

• Do not take if you are hypersensitive to the drug, during pregnancy or breastfeeding.
• May cause an allergic reaction.

It has a detoxifying and hepatoprotective effect. It has an effect at two stages - in the intestines and during metabolism.

The drug is able to absorb harmful components from the intestines and restore liver cells. The composition includes essential phospholipids, amino acids, vitamins, cytochromes, trace elements, mesenchymal enzymes.

"Hepatosan" prevents the absorption of toxins and metabolic products from the large intestine. Also strengthens the walls of liver cells.

Prescribed for the treatment of liver cirrhosis, poisoning with mushrooms, alcohol or medications, chronic and acute forms of liver failure, cholelithiasis. Capsules are intended for oral use.

The dosage and duration of treatment depends on the complexity and type of disease.

• Supports the liver, pancreas, and gastrointestinal tract.
• Quick effect.
• Easy to take.
• Can be combined with other drugs, for example, Enterosan.
• Available in almost all pharmacies.

• There are side effects.
• You can take the drug during pregnancy only under the supervision of a doctor.
• Causes allergies.

The hepatoprotective drug has detoxification properties. Restores liver parenchyma, changes the synthesis of methionine and choline.

Prevents fat filtration. Contains vitamin B12.

The component ensures normal maturation of red blood cells and also promotes better hematopoiesis. It also contains amino acids, fatty acids, and carbohydrates.

Available in the form of an injection solution. Suitable for intravenous and intramuscular slow administration.

You need to mix the drug with blood or sodium chloride (0.9%). Before treatment, it is important to check the body's reaction to possible hypersensitivity.

conclusions

The liver is one of the most vulnerable organs. Suffers from poor diet, alcohol abuse and sedentary lifestyle. Various types of things can also harm the organ. inflammatory processes. There are several types of drugs for treating and restoring the organ. Before use, be sure to consult a specialist. As a rule, in such cases, appropriate diagnostics are prescribed. You can also check information about medications on pharmacy websites in the section “Medicines for the liver.”

One of the most important unpaired organs human body is the liver. In the modern lifestyle and rhythm of life, maintaining her health is quite difficult. Bad habits, environmental situation, sedentary lifestyle, and diet have a negative impact on the condition of the organ. With any liver disease, the entire body suffers. After all, iron is considered a filter that rids a person of toxins, heavy metals. Doctors recommend periodically cleaning the liver and taking special medications to restore its normal functioning. For this purpose, hepatoprotectors are most often used. What are they and how do they affect the liver?

What are hepatoprotectors?

IN Lately It is hepatoprotectors that have gained immense popularity in the treatment of various liver diseases. In addition, these drugs can also be taken for prevention. This makes hepatoprotectors a universal remedy. So, a hepatoprotector is medicinal drug, aimed at restoring liver hepatocytes, restoring and maintaining the normal functioning of the organ.

Hepatoprotectors can be used to protect hepatocytes from the negative effects of harmful substances, toxins, and poisons. Doctors prescribe such drugs for various pathologies of the gland, even with viral lesions organ. Hepatoprotectors for the liver are necessarily prescribed when alcohol intoxication. There are quite a few types of these medications. And not all of them are equally suitable for every patient. Thus, herbal preparations can be harmful in case of individual intolerance to certain herbs or allergies. Therefore, the medicine is selected and prescribed exclusively by the doctor, taking into account all the individual characteristics of the patient’s body.

In general, hepatoprotectors have the following main effects:

• Promotes rapid regeneration of hepatocytes and liver cells;
• Increases the resistance of liver cells to negative factors;
• Neutralizes the effects of toxins;
• Restore metabolism;
• Completely normalize the functioning of the gland.

When is it necessary to take hepatoprotectors?

Certain types of hepatoprotectors are designed for different purposes. The drugs differ in their active substances ohm, its concentration, the nature of the impact. But, all of them are intended to treat the liver. The drugs are usually used for hepatitis of a viral and alcoholic nature. In the first case, these drugs are prescribed when the effectiveness of antiviral medications is low. Also, hepatoprotectors will prevent the development of complications in the form of liver cirrhosis.

In the case of alcoholic hepatitis, medications are prescribed to prevent cirrhosis. Therefore, hepatoprotectors are always included in complex therapy. It is very important to completely stop drinking alcohol during the treatment period, otherwise the treatment will be absolutely ineffective. Also, hepatoprotectors are used in the following cases:

• Alcoholic cirrhosis of the liver;
• Fatty hepatosis;
• Toxic hepatitis;
• Hepatomegaly;
• The period after chemotherapy;
• When taking antibiotics.

In case of liver hepatosis, these drugs are part of complex therapy. At the same time, it is very important to follow a strict diet for quick recovery all organ functions. Otherwise, the liver tissue will be completely replaced by connective tissue, which will make the liver unusable. Taking antibiotics and a period of chemotherapy place additional stress on the organ, which can impair its functions. In order to protect the organ, hepatoprotectors are prescribed.

Main types of hepatoprotectors

Hepatoprotectors and drugs for the liver are divided into several types. They differ in their composition, main active ingredient, release form, and purpose. Therefore, only a doctor can determine the most suitable option. Thus, essential phospholipids, dietary supplements, preparations of plant origin, products of animal origin, amino acids, vitamins, and synthetic preparations are isolated.

Essential phospholipids

Liver cells have a phospholipid layer. Essential phospholipids are used to renew the membrane of liver cells. The active components of such drugs are practically integrated into hepatocytes, restoring their integrity. Such hepatoprotectors gained their popularity due to their safety. Phospholipids are often prescribed to children of any age, girls during pregnancy and breastfeeding.

The effectiveness of the products has been proven by numerous studies. And adverse reactions are extremely rare. Prominent representatives of essential phospholipids are the following medications:

• Essentiale;
• Phospholip;
• Enerliv;
• Hepaforte;
• Rezalut;
• Livolin.

Preparations of animal origin

These drugs are made from the liver cells of cattle or pigs. Medicines of animal origin not only restore liver function, but also cleanse the bile ducts and gallbladder. Very often they are used for alcoholic cirrhosis of the liver, hepatitis, and liver failure. It is worth noting that animal hepatoprotectors are sold only by doctor's prescription. The best among these are the following medications:

• Gepadif;
• Sirepar;
• Prohepar;
• Hepatosan.

Synthetic hepatoprotectors

Synthetic drugs are most effective for certain liver diseases. Thus, these medications are prescribed in the presence of cholesterol stones, biliary cirrhosis, toxic damage, and reflux gastritis. They are often made from uvodeoxycholic acid. Their high effectiveness has been confirmed in the treatment of the initial stage of sclerosing cholangitis, viral hepatitis in pregnant women, children, and cancer. These synthetic drugs actively reduce cholesterol levels in the blood, improve gastric secretion, and promote normal bile excretion. Experts note the high effectiveness of such drugs: Urdoxa, Antral, Eschol, Ursosan, Rezodlut, Cryomelt, Essliver.

Hepatoprotectors of plant origin

Medicines are made based exclusively on herbal, natural ingredients. The main active ingredients are most often seed oil, artichoke leaves, milk thistle, chicory root extract, licorice, senna, nightshade or St. John's wort. Also, plant hepatoprotectors include natural flavonoids, for example silicristin, silibinin, silydianin. The drugs are aimed at accelerating the process of restoration of liver function after treatment. Also, specialists prescribe herbal preparations for preventive cleaning of the gland. The best representatives of this group are the following medications:

• Silimar;
• Gepabene;
• Geparsil;
• Liv-52;
• Holenzyme;
• Galstena;
• Karsil;
• Silegon;
• Hepel.

Amino acids

It has long been proven that amino acids are required by both patients and healthy people. Subject to correct healthy eating, the necessary amino acids enter the body along with foods. In case of amino acid deficiency, their additional intake is prerequisite maintaining health. Thus, hepatoprotective amino acids are necessary for people with any liver lesions and disorders. But, such drugs are less effective in treatment compared to previous representatives. Therefore, for the purpose of treatment and not prevention, amino acids are prescribed in rare cases. This group is represented by Heptor, Heptral, Methionine.

Vitamins for the liver

Previously, only vitamins were used to treat the liver, vitamin complexes. Today, vitamins are also actively used in the complex therapy of liver diseases. Also, vitamins can be used for prevention for healthy people. But powerful therapeutic effect vitamins do not work. The following multivitamins have a positive effect on the liver: Suprastin, Undevit, Complivit, Vitrum.

Dietary supplements to restore liver function

Many doctors rarely use dietary supplements to normalize liver function. Also, dietary supplements do not guarantee effective cleansing biliary tract, gallbladder. But modern manufacturers of these drugs have proven themselves quite well. Among such food additives are Hepatrin, Ovesol, Dipana, Hepatotransit.

List of drugs with proven effectiveness

It is known that the liver membrane does not have nerve endings. Therefore, determine the initial stage of any gland disease by pain impossible. The patient complains only in cases when the problem begins to affect neighboring organs. Liver dysfunction can be detected by donating blood during a test, or by performing an ultrasound examination of the abdominal organs.

For treatment serious illnesses liver, new generation hepatoprotectors have been developed. They are highly effective in chemotherapy. So, hepatoprotectors with proven effectiveness in this case are the following:

• Silymarin;
• Hepaliv;
• Eslidin;
• Glycyrrhizin;
• Ursosan;
• Liver Pro.

Silymarin is made from milk thistle extract, which is actively used to treat gland diseases. The drug protects the liver during chemotherapy from cancer cells, as it neutralizes the effects of free radicals. Liver Pro has a protective effect on liver cells from drugs and toxins. Eslidin has a complex effect. The medication not only protects the organ, but also restores metabolic processes in the body. This hepatoprotector is used in cardiology, endocrinology, oncology, dermatology, and neurology.

Also, effective drugs new generation, with proven therapeutic effects, used for the treatment of hepatitis of various etiologies. The hepatoprotector Lohein has proven itself well. The effectiveness of this medicine lies in the protection and restoration of hepatocytes that have been exposed to toxic, viral, and alcoholic influences. Lohein is prescribed not only for hepatitis, but also for the following problems: helminthiasis, intoxication of the body, tuberculosis, cholangitis, cirrhosis, jaundice, rheumatoid arthritis, lupus, prevention of premature aging of body cells.

This list can be continued with the drug Katergen. This medication is actively used to improve liver function in viral hepatitis. Also, Katergen is prescribed during the compensated stage of cirrhosis, treatment of alcoholic cirrhosis, and any toxic damage to the gland. The action of the drug is aimed at binding toxins and free radicals, removing them and restoring liver cells. Also, the following new generation hepatoprotectors can be noted: Tykveol, Eplir, Bondizhar.

The best hepatoprotectors for children

Most hepatoprotectors are prohibited for use by children under three years of age. Therefore, it is very difficult to choose an effective medicine for a child. The liver can function normally only if the hepatocyte membrane is intact. If the membranes are damaged or clogged, immediate correction is required. Often these anomalies are diagnosed in children of any age, even newborns. It is important to remember that hepatoprotectors for children are prescribed only by a doctor, and administration is carried out only under his supervision.

Medicines for newborns

For newborn babies, the best hepatoprotector is Hepel. The remedy is classified as a homeopathic medicine. Available in the form of injection solution and tablets. The medication has the following effects:

• Choleretic;
• Hepatoprotective;
• Anti-inflammatory;
• Antispasmodic;
• Antidiarrheal.

Also, the remedy can be prescribed to get rid of bloating, eczema, and normalize appetite. For newborns, the best option is to use the product in the form of an injection, which is carried out only by a doctor. Among the contraindications for use, only individual intolerance to the components of the drug is noted.

Another safe hepatoprotector for newborn babies is Galstena. This is also a combined homeopathic remedy that has hepatoprotective, cholekinetic and choleretic effects. For young children it is recommended to use Galsten in drops. Should be taken between feedings. The dosage and course of therapy are prescribed only by the attending doctor.

Medicines for children over three years old

For children over three years of age, Duphalac and Essentiale are used. The first drug is known to many as a mild laxative. It comes in syrup form, which is very convenient to use. Duphalac improves intestinal motility, normalizes microflora, and eliminates constipation. Also, Duphalac is actively used for the treatment of hepatic encephalopathy and precoma. The medicine will help reduce the level of toxic components, neutralize their harmful effects not only on the liver, but also on the brain.

Also, small children can be given the hepatoprotector Essentiale. The main active ingredient is phospholipids, which will actively restore the membrane of liver cells and hepatocytes in general. The medicine can be used for any liver disease. Essentiale is available in the form of capsules and injection solutions. The course of treatment is determined by the doctor depending on the disease and the degree of damage.

Medicines for children over four years of age

Children of this age category are allowed any hepatoprotectors based on milk thistle extract. Methionine, Antral, Gepabene are popular. Thus, Antral belongs to the list of hepatoprotector drugs, which has both therapeutic and preventive effects. Taking the course will help reduce bilirubin levels, activate blood enzymes, and establish normal liver function. The medicine does not have a harmful effect on other systems and organs of the body.

The drug Gepabene has a completely natural composition, including various plants. It has a choleretic effect, protects gland cells from the effects of toxins and free radicals. Among the indications for prescribing Gepabene, it is worth noting the treatment and prevention of diseases of the bile ducts, liver inflammation, and toxic hepatitis.

Hepatoprotectors for children 6-12 years old

For this age category, Ursosan, Karsil, Legalon are excellent options for treating the liver. The last hepatoprotector is a herbal remedy. The product is famous for its hepatoprotective and antitoxic effects. Stabilizes liver cell membranes, saturates hepatocytes with enzymes. In addition, Legalon activates the production of phospholipids and proteins, and accelerates liver regeneration. When prescribing any medications, the doctor always takes into account the patient’s age. Only with this approach to treatment will therapy be as effective as possible.

Liver diseases are one of the common causes of disability and mortality in all countries, despite their economic development and climatic conditions. Every year, about 1 million people fall ill with liver diseases, most of whom are young, able-bodied people.

Experts note that the development of new drugs, vaccination and modern methods diagnostics do not show a positive trend: people continue to get sick with hepatitis, cirrhosis, cancer, which is associated with many factors: alcoholism, unbalanced diet, poor environment, chronic diseases.

To alleviate the condition of victims and prevent the destruction of hepatocytes, many drugs have been developed, in particular, hepatoprotectors. Together with dietary nutrition and basic therapy, they normalize the basic functions of the liver, help restore its structure, and protect against the toxic effects of harmful compounds.

Any disease that affects the liver causes serious disruption in almost all body systems, since the organ performs a number of important functions, in particular the liver:

• responsible for protein, carbohydrate, lipid, pigment metabolism;
• neutralizes the harmful effects of toxins and drugs;
• stores vitamins and microelements;
• produces cholesterol and lipids;
• regulates blood clotting;
• responsible for the production of bile acids and their transport to the gallbladder;
• stimulates intestinal function;
• synthesizes and inactivates some hormones, including sex hormones;
• produces enzymes;
• is a blood repository.

Nature, having endowed the liver with so many functions, took care of its integrity. This is the only organ that can recover even after partial removal. But the body cannot always cope with some factors on its own, namely:

• obesity;
• alcohol;
• medications;
• genetic factors;
• drug use;
• poor environment;
• diabetes mellitus;
• physical inactivity;
• improper nutrition.

Although the liver is capable of recovery, prolonged excessive stress sooner or later disrupts its activity. Hepatoprotectors are designed to protect the liver from such factors. They, of course, will not replace basic therapy, but will complement the effect of prescribed medications and can improve the function of liver cells.

For liver pathologies (hepatitis, hepatosis, fibrosis, cirrhosis, liver failure, cancer, etc.) and forced prolonged use of certain medicines(anticonvulsant, antitumor, painkillers) the doctor must prescribe hepatoprotectors.

Recently, a myth has formed that this class of drugs is just an invention of “greedy” pharmacists who want to profit from the grief of patients and produce drugs with dubious effectiveness. Opponents of these drugs rely on the fact that in Europe and the USA, liver treatment is not carried out with such medications, since they do not exist in the list of pharmacological agents.

But in the same list there is another group of medications - cytoprotectors, which have a positive effect on the metabolism of the liver, kidneys, heart, dermis, which includes the well-known hepatoprotectors.

In addition, hepatoprotectors are called pharmaceuticals abroad, and some companies, for profit and convenience of registration, position them as dietary supplements (BAS). Not particularly honest manufacturers actually produced ineffective drugs using such hepatoprotector dietary supplements, which was the reason for the mistrust of patients and medical practitioners.

Meanwhile, by purchasing dietary supplements that have not passed clinical trials, which are not effective and do not help, patients waste time (for most liver diseases there is a period when the pathology can recur, and then only organ transplantation), hoping that one tablet will solve all their problems .

Patients should clearly understand that the use of clinically proven hepatoprotectors does accelerate liver recovery, but does not cancel diet and basic medications.

Modern hepatoprotectors can soften and alleviate liver disease, but they have their limits of effectiveness, and one cannot hope that this is a panacea for all problems with the organ.

Properties and types

There are several classes of hepatoprotectors, based on different components and having a specific mechanism of action, but they all have similar properties:

• they are based on natural ingredients;
• they restore the functioning of the diseased organ and normalize metabolism;
• remove toxins and neutralize their effects;
• accelerate the regeneration of hepatocytes, increase their resistance to harmful factors.

According to the mechanism of action, there are 6 types of hepatoprotectors based on:

• ursodeoxycholic acid;
• flavonoids from other plants;
• animal components;
• essential phospholipids;
• amino acids.

Based on ursodeoxycholic acid

The functions of ursodeoxycholic acid, which was previously extracted from bear bile and is now synthesized in laboratories, include:

• liver protection. With the help of acid, special particles are produced that neutralize bad influence toxins;
• restoration of bile outflow and dilution of secretions, which promotes normal digestion and its discharge into the intestines;
• lowering cholesterol by reducing its synthesis and dissolving cholesterol stones;
• strengthening immunity;
• positive effect on the bile ducts.

Hepatoprotectors ursodeoxycholic acid, in addition to the listed properties, have an antioxidant effect. Thanks to this, liver cells and the entire body are less susceptible to aging. Indications for prescribing such drugs are:

• toxic liver damage, including alcohol and drugs;
• hepatitis;
• bile duct dyskinesia;
• hepatosis;
• bile stagnation;
• cholangitis;
• cystic fibrosis;
• reflux gastritis;
• dyspeptic syndrome.

The most famous are:

They can be prescribed for long-term treatment (from 3 to 6 months), and are allowed for children. The disadvantage of the main ingredient is that it cannot be prescribed for:

• acute conditions of the intestines and gall bladder;
• problems with the functioning of the pancreas;
• renal pathologies;
• pregnancy and breastfeeding.

With prolonged treatment, side effects (digestive upset) are observed. Therefore, it is not recommended to self-prescribe medicine to improve health and strengthen the liver. Only the doctor determines the dosage and duration of the course of therapy, depending on the individual characteristics of the patient and the detected diseases.

With milk thistle

The most trusted drugs are those with plant based. Especially popular are the fruits of milk thistle, which contain many biologically active components (microelements, vitamins, organic acids).

Preparations based on milk thistle significantly reduce the toxic effect on the liver and promote the regeneration of cellular structures. In damaged hepatocytes, protein production is stimulated, cell membranes are stabilized, and the loss of trace elements stops, thereby increasing the natural regeneration of liver cells.

Some of the most popular medications include:

They are shown when:

• hepatitis;
• cirrhosis;
• steatosis;
• sudden weight loss.

These drugs are used to prevent liver pathologies during long-term medication use and chronic alcoholism. They are often well tolerated by patients and rarely cause side effects.

Flaws:

• decreased efficiency oral contraceptives when taken together;
• not prescribed for lactating and pregnant women;
• are not prescribed for diseases of the female reproductive system (benign tumors, hormonal disorders, malignant neoplasms);
• are not compatible with a number of drugs, such as Diazepam, Ketoconazole (may enhance their effect).

With flavonoids from other plants

Milk thistle tablets are not the only herbal medicines that restore and protect the liver. Celandine, artichoke, pumpkin seeds, and fuming can act as active ingredients in a number of hepatoprotectors.

They are distinguished by a minimal number of side effects, the ability to eliminate spasms of the gallbladder, and improve the outflow and production of bile. For example, Allochol, which is not a hepatoprotector, also consists of plant components, but causes a lot of side effects. These drugs are prescribed for:

• hepatitis of various origins;
• gallbladder dyskinesia;
• cholecystitis;
• cirrhosis;
• hepatosis;
• exhaustion.

Disadvantages include the ability to provoke allergies and stool disorders. Not prescribed for pregnant and lactating women. The list of popular drugs includes:

With animal ingredients

Preparations created from pork liver are capable of regenerating hepatocytes of the human liver, since they are as similar in composition as possible. Thanks to their detoxification and antioxidant effects, they treat hepatitis, hepatosis and cirrhosis of the liver. From positive qualities note:

• the ability to remove toxins from the body;
• accelerate the regeneration of hepatocytes;
• restore lost liver functions.

• high risk of allergies;
• the risk of developing immunopathological syndromes in acute forms of hepatitis;
• they are not suitable for the prevention of liver diseases.

Clinically proven hepatoprotectors of this group include:

1. Sirepar, which has a detoxifying, liver-restoring effect.
2. Hepatosan has a metabolic effect that restores the functions of hepatocytes.

With essential phospholipids

According to statistics, these drugs are most common in post-Soviet regions. They are obtained from soybeans. Phospholipids are products of lipid metabolism, which are kind of building blocks for the construction of cells.

These substances are involved in transport nutrients, cell division and differentiation, they activate various enzymatic systems. The advantages of hepatoprotectors based on essential phospholipids include:

• the ability to quickly restore hepatocytes at the molecular level;
• protection against toxins and viruses;
• improvement of the action of interferons;
• preventing the formation of scar tissue.

Such medications include:

They are prescribed for:

• acalculous cholecystitis;
• hepatitis;
• hepatosis;
• cirrhosis;
• neurodermatitis;
• psoriasis.

Among the disadvantages, they note the need for prolonged use of drugs in order to feel their effectiveness. Sometimes phospholipids cause bile stagnation. In addition, they are quickly broken down in the stomach, and only a small proportion of the active substances reaches its destination - the liver.

Other types

In the liver, amino acids participate in the production of phospholipids, break down fats, quickly restore hepatocytes, and remove toxins. The most popular acid in this class of hepatoprotectors is ademetionine, an amino acid involved in various biochemical processes occurring in the body. It improves the quality of bile, reduces its toxicity, and promotes the rapid outflow of bile acids. Also used:

Used in the treatment of:

• fatty hepatosis;
• hepatitis A;
• pancreatitis.

The list of main drugs includes:

These drugs are more likely to cause side effects than others. These include the occurrence of such violations:

• diarrhea;
• nausea;
• pain in the epigastric region.

Patient Experience

Let's consider the opinions of patients regarding the effectiveness of hepatoprotectors:

Anton: “I have had epilepsy since I was 21. As soon as anticonvulsant therapy was selected, the neurologist prescribed Karsil. I didn’t believe I would need it because I was taking handfuls of PEPs and didn’t want to add more medication to it. But after 3 years, liver tests worsened, and I had to cleanse my liver. Since then I’ve been taking hepatoprotectors twice a year and following diet No. 5.”

Anna: “Six months after giving birth, I was diagnosed with cholelithiasis due to high water levels during pregnancy. The uterus blocked the flow of bile, which caused stagnation and the formation of stones. I was not able to receive full treatment, since most medications cannot be taken by breastfeeding women, so I stuck to a diet and drank Borjomi.

No-shpa was prescribed as a pain reliever. All this time I felt disgusting, experienced colic, nausea, heaviness in my side and pain. When I stopped feeding, I went for an ultrasound. They said that from my 0.2 cm stones, they turned into 0.6 cm stones.

The doctor prescribed Ursofalk 2 capsules at night. After 3 months, I underwent a re-examination, which showed that my stones began to dissolve. I’ve been taking the drug for a year now, and I hope that the next diagnosis will show a positive result.”

Vera Olegovna: “I was registered with my illness and regularly donated blood. The drug Phosphogliv was prescribed to me by my attending physician. I can’t say that it somehow protected my liver and improved my condition. It happened that I did not take hepatoprotectors for years, and sometimes I drank it regularly. I didn't notice any difference.

Each time I used them I felt sick and, interestingly, I got a runny nose. When the diagnosis was finally removed and the main treatment stopped, the liver tests returned to normal. This was not associated with hepatoprotectors. As soon as I stopped taking the medications, everything returned to normal. I consider these drugs to be a simple money grab.”

Today there is great amount hepatoprotectors. Attitudes towards them vary among both patients and doctors. Experts consider the most effective of them to be Heptral, Hofitol, Essentiale, Ursosan, Karsil, Silimar and recommend taking them for any liver dysfunction.

But, despite the popularity and apparent safety of these drugs, treatment should not be started without consulting a specialist. Each medication has its own indications and contraindications. With an illiterate approach and non-compliance with recommendations, you can aggravate your condition and cause irreparable harm to your health.

Medicines for the liver are hepatoprotectors that are prescribed by a doctor for various liver dysfunctions, hepatitis (viral, toxic), when the liver is damaged when taking drugs that have a negative effect on its cells (antitumor, painkillers, anti-tuberculosis drugs, antibiotics wide range actions, etc.)

What medicine for the liver is considered the best, good, effective and not expensive? What medicine restores the liver, is used for prevention, to support the liver? Today, the pharmaceutical industry offers a lot of tablets supposedly to restore the liver:

• amino acid derivatives
• phospholipids
• bile acids
• herbal remedies
• preparations of animal origin
• homeopathic medicines

but an ideal medicine for treating the liver that quickly and effectively restores its tissue has not yet been created. As prescribed by a doctor, hepatoprotectors are taken throughout the adverse effects of provoking factors, as well as after their influence ends. It should be noted that a one-time use of medications for the liver after alcohol, a heavy meal, overeating, or taking toxic drugs does not give any effect.

When are hepatoprotectors needed?

In Russia there is a huge selection of hepatoprotectors, and these drugs are used very often. Moreover, the cost of the course of treatment costs patients large amounts of money, and many do not feel the result. Disputes about the need and advisability of such therapy have been going on for a long time; in our country, a doctor can prescribe hepatroprotectors in the following cases:

• Viral hepatitis(see) - they are prescribed if they do not help antiviral drugs or for some reason antiviral treatment is not possible. In this case, hepatoprotectors can be used for prevention in complex treatment.
• Alcoholic hepatitis threatened by liver cirrhosis- in this case, you should give up alcohol, these drugs do not have a significant effect. If alcohol intake continues, whether the patient uses hepatoprotectors or not is not important. No, even the best medications for the liver will help if a person continues to drink alcohol.
• Fatty liver disease (non-alcoholic)- in obese patients or in patients with type 2 diabetes mellitus fat cells are also formed in the liver, which leads to its destruction (see). In this case, hepatoprotectors are needed to accelerate the effect only when integrated approach for therapy - a diet to promote weight loss, increase physical activity, antidiabetic drugs, cholesterol reduction (see).
• Drug-induced hepatitis (toxic), primary biliary cirrhosis— certain hepatoprotectors are prescribed in complex therapy.

It should be understood that it is impossible to restore the liver with medications alone; you should follow a diet, limit alcohol intake, quit smoking, and also treat accompanying illnesses, since the patient often has impaired functions of other organs involved in digestion - the gallbladder, pancreas.

Why are hepatoprotectors as a class of drugs available only in Russia and the CIS countries?

The class of drugs “hepatoprotectors” exists only in Russia and the CIS countries, neither in Europe nor in North America, nor in Australia, most of them are not registered. They are not included in the list of tablets for the treatment of liver diseases due to the fact that their therapeutic effectiveness has not been proven and clinical significance has not been confirmed.

Very rarely, some of them are used in the USA and Europe for narrow indications, used as dietary supplements (that is, their use does not guarantee effect). The French company Sanofi, one of the manufacturers of Essentiale, sends 99% of its production to Russia and the CIS countries, since no one in the world needs this drug.

It is worth noting that the pharmaceutical market in the 21st century is a very profitable business, in which competition is as fierce as in any sector of the market economy. And today it is very difficult to determine how effective a particular drug is, since research (very expensive) is funded by interested parties.

Liver preparations - essential phospholipids

• fatty liver degeneration
• liver cirrhosis
• chronic hepatitis
• toxic hepatitis
• alcoholic hepatitis (see)
• radiation syndrome

Is it really? Below we present two points of view, one - these instructions for essential phospholipids and known studies of effectiveness, and the other - other information about the studies that contradict the advertising campaign of this group of drugs.

Positive opinion— What do the instructions for using these capsules say? Essential phospholipids (derived from soy) are components of the cell wall of hepatocytes. The effect of phospholipids is that they penetrate the lipid layer of the walls of damaged cells, improving their functions.

Many believe that essential phospholipids are capable of restoring liver cells; this is not entirely true, since their action only improves the condition of the cell walls. When taking phospholipids, the energy costs of the liver are reduced, enzyme activity increases, and the physicochemical properties of bile are improved. To obtain noticeable results, these tablets should be taken for a very long time (up to six months). The greatest effect is achieved with intravenous administration of Essentiale Forte.

By the end of 2001, 186 were produced clinical trials, which included more than 11,000 patients, which allow us to draw conclusions about the effectiveness of these drugs. Essential phospholipids increase the likelihood of a response to α-interferon (c), are well tolerated by patients, and reduce the frequency of relapses after completion of α-interferon therapy.

Negative opinion- It was initially assumed that essential phospholipids are effective as a “drug cover” when taking hepatotoxic drugs, alcoholic, viral hepatitis and liver steatosis of various origins.

However, a 2003 US study of veteran medical centers, did not reveal any positive effect of these drugs on liver function. In addition, it was found that against the background of viral hepatitis, both acute and chronic, taking essential phospholipids contributed to the activation of inflammation, since it provoked stagnation of bile. Based on these studies, their use in the treatment of viral hepatitis is not advisable.

Moreover, it is known that various B vitamins that are added to some products (Essliver Forte) are not recommended to be taken at the same time (see). According to some sources, liver tablets like Essentiale hardly reach the liver, but are distributed and metabolized throughout the body, which calls into question their effectiveness. But the cost of treatment with these drugs is very high - just for a month’s course of treatment (in capsules) an adult needs more than 3,000 rubles.

Conclusion: Now in clinical practice Essential phospholipids are widely used for non-alcoholic steatohepatitis, toxic liver damage, and as a cover-up for hepatotoxic drugs, but the effectiveness remains in doubt. In addition, in case of active hepatitis, their use requires caution or refusal to use, since this may increase the activity of the process and increase cholestasis.

List of essential phospholipids

Essentiale N, Essentiale forte N Composition: essential phospholipids. Side effects: well tolerated, sometimes diarrhea and abdominal discomfort are possible. Contraindicated in children under 12 years of age. Average price in pharmacies 2018: 30 pcs. 660 RUR, 5 amp. 950 rub. 90 pcs. 1300 rub.

Essliver Forte Ingredients: essential phospholipids (less than in Essential), vitamins (B1, B2, B6, E, PP, B12) Side effects: possible diarrhea, pain in the upper abdomen With caution for children under 1 2 years old, pregnant and lactating women. Price: 30 caps. 300 rub, 50 caps. 420 rub.

Composition: Lipoid C100 and Silymarin () Price: 30 caps. 420-480 rub.

Gepagard Active Ingredients: essential phospholipids, vitamin E Price: 30 caps. 300 rubles, 120 drops.. 900-950 rubles.

Ingredients: phospholipids, trisodium salt of glycyrrhizic acid (antiviral and immunomodulatory effects) Price: 50 caps. 450-500 rub. powder for injection 5 pcs. 1300-1500 rub.

Rezalut PRO Composition: Lipoid PPL 600, which contains: medium chain triglycerides, phospholipids, glycerol mono/dialconate, soybean oil, vitamin E. Price: 30 caps. 450 rub., 100 caps. 1300 rub.

Doppelhertz active essential phospholipids Compound: Essential phospholipids, Vitamin B1, B2, B6 Price: 60 caps. 460 RUR, 5 amp. 640 rub.

Eslidin Composition: phospholipids + methionine Indicated: For liver diseases, diabetes mellitus, psoriasis, dystrophy and exhaustion, atherosclerosis of the coronary arteries and cerebral vessels . Contraindicated: children under 3 years of age, pregnant and lactating women with caution. Price: 580 -720 rub.

Tablets - bile acids

Ursodeoxycholic acid is a bile acid preparation. Used for the treatment of diseases of the biliary tract and liver, uncomplicated cholelithiasis. It has a hypoglycemic and choleretic effect, therefore it is contraindicated in the presence of X-ray positive (high calcium content) gallstones (see also), reduces the saturation of bile with cholesterol (until the cholesterol stones are completely dissolved), causes an increase in pancreatic and gastric secretion. Affects immunological reactions in the liver - reduces, affects the formation of interleukin-2, the number of T-lymphocytes.

Since drugs containing ursodeoxycholic acid have a number of serious contraindications(acute inflammatory processes in the intestines, gall bladder, severe dysfunction of the pancreas, kidneys and liver, gallstones), and also have an immunomodulatory effect - their Use without doctor's advice is dangerous.

These drugs are used for:

• biliary reflux gastritis,
• For symptomatic treatment with primary biliary cirrhosis of the liver,
• to dissolve cholesterol stones in the gall bladder,
• alcohol, toxic liver damage,
• acute hepatitis, with hepatopathy in pregnant women.
• UDCA is the most effective means for the treatment of primary biliary cirrhosis, primary sclerosing cholangitis.

Pathogenetic therapy with ursodeoxycholic acid is carried out for patients with viral hepatitis with aggravating factors - during pregnancy, alcoholic viral liver damage, hemophilia, in adolescence, with oncohematological diseases, drug and substance abuse.

10 caps. 250 rub, 50 caps. 1000 rub. 100 caps. 1800 rub. susp. 1200 rub.	exhol 10 pcs 200 rub. 100 pieces. 1500	Urosliv 10 capsules. 160 RUR, 100 caps. 1300 rub.	100 caps. 1100 rub.
Grinterol 50 pcs. 700 rub 100 pcs 1400 rub.	100 caps. 1200 rub.	50 pcs. 300 rub. 100 pieces. 900 rub.	10 caps. 200 rub. 100 caps. 1500 rub.

Liver tablets of animal origin

Positive opinion: There are literally two such tablets for the liver - Sirepar and Hepatosan, they are not used for prophylaxis and are dispensed with a doctor’s prescription, used only for the treatment of liver diseases according to indications (cirrhosis, hepatitis, medicinal and toxic hepatitis). They are produced from pig liver cells (Hepatosan) and from cattle liver hydrolysate (Sirepar), contain amino acids, cyanocobalamin, low molecular weight metabolites and fragments of liver growth factors. It is believed that these liver tablets have a hepatoprotective effect, detoxification, antioxidant properties, and stimulate the regeneration of liver parenchyma.

There is also a complex drug Progepar (composition: inositol, cyanocobalamin, liver extract KPC N (liver hydrolysate), cysteine ​​hydrochloride), improves blood flow in the liver tissue, restores the structure of hepatocytes, stops the formation of connective tissue in the liver, improves functional indicators of liver function, increases diuresis . It is used in the complex treatment of chronic hepatitis, cirrhosis, fatty liver, radiation sickness, and drug intoxication.

Negative opinion: There is no evidence base confirming their clinical effectiveness and safety. Moreover, taking these drugs is potentially dangerous:

• They should not be prescribed to patients with active forms of hepatitis, since the phenomena of immunopathological, mesenchymal-inflammatory and cytolytic syndromes may increase.
• These drugs have a high allergenic potential, so before starting treatment, it is necessary to determine whether there is increased individual sensitivity to the drug.
• The use of cattle liver hydrolysates increases the risk of contracting a patient with prion infection, which causes spongiform encephalopathy (fatal neurodegenerative disease - Creutzfeldt-Jakob disease). At the end of the 20th century, interest in this pathology arose when iatrogenic transmission of prions by administration of contaminated gonadotropin was demonstrated in 250 patients with spongiform encephalopathy.

Due to their potential danger and unproven effectiveness, it is not advisable to use drugs in this group for the treatment of liver pathologies.

Liver treatment with amino acids

Ademetionine - Heptral, Heptor

Positive opinion— Amino acids, for example, ademetionine, take part in the synthesis of biologically active substances and phospholipids, and have regenerating and detoxifying properties. By the end of 1 week of use, Heptral also exhibits a pronounced antidepressant effect, breaks down fats and promotes their removal from the liver. These medications are used for fatty liver hepatosis (fatty degeneration), chronic hepatitis, toxic hepatitis, withdrawal syndrome, and depression.

Analysis of clinical studies conducted indicates the clinical effectiveness of ademetionine and indicates a pronounced hepatoprotective effectiveness in alcohol and drug-induced liver damage, cholestatic liver diseases (primary biliary cirrhosis), and chronic viral hepatitis. It has choleretic and cholekinetic effects, antioxidant, neuroprotective and antifibrosing properties.

Negative opinion— Heptral is registered as a medicine in Germany, Italy, and Russia. In Australia it is registered as a drug for animals (veterinary), in other countries as a dietary supplement, since studies have shown a dubious effect.

Practicing doctors - gastroenterologists, infectious disease specialists, hepatologists know that this drug very effective, but only when intravenous infusions, since only a small part of the drug is absorbed when taken orally. Therefore, Heptral in tablets for serious liver pathology is almost a waste Money, as opposed to intravenous use.

Ingredients: active ingredient ademetionine Has an antidepressant, regenerating, antioxidant effect. Slows down the development of liver cirrhosis. Side effects: There may be heartburn, stomach pain. Price: 20 tablets or 5 fl. 1700 -1800 rub.

Ingredients: active ingredient ademetionine Just like Heptral, it is indicated for toxic liver damage, depression, liver cirrhosis, treatment of the consequences of alcohol abuse. Contraindicated: for children, during lactation and in the first and second trimester of pregnancy. Price: 20 tablets 800-1000 RUR, 5 fl. 1200 rub.

Ornithine aspartate - Hepa-Merz

Positive opinion— Ornithine helps reduce high level ammonia, is used for disorders of brain function associated with impaired liver function, as well as for fatty degeneration and toxic hepatitis. This medicine is practically not used for prevention.

The effectiveness of Hepa-Merz was proven in a randomized multicenter study in patients with liver cirrhosis with elevated levels of ammonia in the blood. It is prescribed for various types hepatitis, non-alcoholic steatohepatitis, especially with hepatic encephalopathy and liver cirrhosis.

Negative opinion- this drug was widely advertised, but in case of alcoholic liver damage it has practically no effect; there is no point in using it for prevention, protection, or restoration of the liver. The only time its use produces a noticeable effect is during hepatic coma for a short-term recovery from it, since ornithine binds components in the blood that are toxic to the brain.

Thioctic acid

Action: normalizes lipid, energy, carbohydrate metabolism, has hepatoprotective and antioxidant properties. Helps reduce blood glucose levels and is used in the complex treatment of hepatitis and toxic liver damage.
Contraindications: children, may lead to a sharp decrease in blood glucose levels (especially in diabetics).
Side effects: nausea, vomiting, diarrhea, itching, headache.

Complex hepatoprotector - Remaxol, infusion solution

Remaxol Compound: succinic acid, meglumine, riboxin, methionine, nicotinamide. Indications: liver dysfunction (toxic, drug-induced, alcoholic hepatitis), treatment of viral hepatitis. Contraindications: pregnancy, lactation, childhood, intolerance. Side effects: redness of the skin, feeling of heat, dry mouth, skin allergies, decreased blood sugar, increased uric acid in the blood (with caution in case of gout). Price: 350-380 rub.

Prevention of hepatotoxic effects of alcohol

Herbal medicines for the liver

Medicines for the liver with milk thistle - Legalon, Karsil, Gepabene, Silimar

Positive opinion:- these drugs are widely used and really effective (see). When asked which medicine is best for the liver, the answer is milk thistle preparations. Silymarin is the collective name for the biologically active substances in the fruits of milk thistle and is a strong antioxidant (and the only antidote for poisoning with toadstool). According to indications, it is prescribed for hepatitis and other liver diseases for a course of at least 3 months, helps reduce the intensity of progression of liver cirrhosis. Preparations with the active ingredient silymarin are a good medicine for restoring and maintaining the liver, as it stimulates the growth of new cells and restores the destruction of cell membranes.

For more effective treatment, it is better not to save money, but to take Legalon with a purer chemical substance and a higher dosage (70 and 140 mg) or Carsil Forte (90 mg) than simple Carsil (35 mg).

Pharmacy chains have a fairly wide selection of milk thistle preparations, both medicines and dietary supplements. Among Karsil's analogues one can highlight Silymar tablet, Legalon, Silibinin, Silymarin, among dietary supplements - milk thistle meal, milk thistle oil, capsules.

Negative opinion: Despite the safety of this drug, the clinical effectiveness of silymarin in alcoholic liver damage and acute hepatitis has not been confirmed due to a lack of adequate research. In acute viral hepatitis B, there was no improvement in liver function tests between the placebo and silymarin groups (see). Data on the effectiveness of its use in acute hepatitis C have not yet been obtained; there are only descriptions of individual cases where milk thistle extract reduced the activity of aminotransferases in chronic hepatitis C. Summarizing today's data evidence-based medicine Based on its effectiveness, it can be stated that today a lot of experimental data has been accumulated to recommend further study of the effectiveness of silymarin in chronic liver diseases (including fatty hepatosis).

Karsil (35 mg) and Karsil Forte (90 mg) Ingredients: milk thistle extract. Application: before meals, with a sufficient amount of water, course for at least 3 months. For prevention, 1 tablet 3 times a day. For children over 12 years of age and adults with severe liver damage, 4 dr. 3 times a day, then 1-2 dr. 3 times a day. Side effects Karsil 80 pcs. 330 rub., Karsil Forte 30 pcs. 380 rub.

Ingredients: milk thistle fruit extract. Application: after eating, without chewing, with a small amount of liquid. Start of treatment 2 caps. 3 r/day, maintenance therapy 1 dr. 3 r/day. Side effects: allergic reactions, diarrhea. Legalon 70 mg: 30 caps. 230 rub. 60 caps. 400 rub Legalon 140 mg: 30 caps - 340 rubles, 60 caps. 600 rub.

Gepabene (milk thistle and smokeweed) Ingredients: herbal fumifera dry extract and milk thistle. Contraindication: children under 18 years of age, acute inflammation of the liver and biliary tract. Application: 1 capsule. 3 times a day For pain, take an additional 1 capsule. before bedtime. Maximum daily dose 6 capsules, take in 3-4 divided doses. Price: 30 caps. 430-570 rub.

Silymar tablets Ingredients: milk thistle fruit extract. Application: for toxic liver damage, cirrhosis, after hepatitis, chronic hepatitis, with prolonged use of alcohol and medications, with intoxication. 1-2 tablets each. 3 times a day for 30 minutes. before meals. Course 25-30 days. After 1-3 months, you can repeat the treatment. Not recommended children under 12 years old. Side effects: possible loose stools and allergic reactions. Price: 30 pcs. 110-150 rub.

Milk thistle tablets (extract) Ingredients: 50 mg silymarin. Application, indications, contraindications and side effects the same as for other preparations with milk thistle extract. Price: 20 pcs. 130 rub.

Milk thistle meal (crushed plant) Application: 1 teaspoon 3 times a day with meals. Contraindications: cholelithiasis, exacerbation of stomach ulcers and duodenum, hypersensitivity, pregnant and lactating women. Side effects: pain in the right hypochondrium, diarrhea, allergies. Price: 60 rub.

Milk thistle oil in capsules Application: adults, 1 capsule. 2 times a day during meals. The course is 1 month, which can be repeated 2-3 times a year. Contraindications: acute gastrointestinal diseases, childhood. Price: 40-60 rub.

Milk thistle syrup Ingredients: milk thistle meal and extract, common thyme herb, tansy flowers. Application: 1 tbsp. spoon 1-2 times a day during meals. Course 4-6 weeks. It is possible to repeat the course up to 4 times a year. Contraindications: children under 14 years of age, pregnancy, lactation, diabetes. Price: 150 ml. 110 rub.

Artichoke - a plant used to treat the liver

Positive opinion: Artichoke is a plant that has been used since ancient times in folk medicine to reduce joint pain, to treat jaundice, as it improves metabolism, helps reduce bad cholesterol, has a diuretic, choleretic and hepatoprotective effect. In artichoke preparations, the main active ingredient is cymarin, which has properties similar to silibinin. Among the preparations with artichoke, one can highlight Hofitol, among the dietary supplements - Cynarix, Artichoke Extract. They are used to relieve alcohol intoxication, for the treatment of cholecystitis, hepatitis,. The drug is low-toxic and is indicated for liver cirrhosis and toxic hepatitis.

Negative opinion: As a hepatoprotector, artichoke leaf extract is widely used, but no evidence-based studies of its effectiveness have been carried out, and it is not recommended for use in acute hepatitis, cholelithiasis and cholestasis syndrome.

bottle 350-400 rub., 60 tab. 300 rub. 180 tab. 600-700 rub.	Solgar Artichoke Leaf Extract Price: 60 caps. 1100 rub.
Artichoke Price: 20 tablets about 120 rub.	Price: 60 tablets 360 rub.

Medicine for the liver - Liv 52, and other dietary supplements

Positive opinion— the manufacturer of Liv 52 claims that the extracts of medicinal herbs included in the drug protect the liver parenchyma in case of toxic damage (drugs, alcohol), normalizes the protein-synthetic function of the liver, has a choleretic effect, stimulates the restoration of liver cells, has a slight antioxidant effect, restores the ratio of some phospholipids factions. Used for hepatitis, anorexia, for the prevention of liver diseases, cirrhosis. Studies conducted in Russia have shown the effectiveness of using Liv 52 in the treatment of hepatitis A in children; the results were published in an article by experts from the Moscow Research Institute of Pediatrics and Pediatric Surgery.

Negative opinion- however, according to the results of various US studies, the declared effects of Liv 52 are not noted. For example, in case of viral hepatitis, taking Liv 52 did not lead to a reduction in treatment time, but a decrease in bilirubin in the blood and a reduction in severe weight loss in patients were observed. In the treatment of alcoholic hepatitis, neither antitoxic nor restorative effects were found. Moreover, the results of one of the clinical studies conducted in the USA led to the withdrawal of this drug from the country's market. In the treatment of alcoholic hepatitis when taking Liv 52, the survival rate in the placebo group was 86%, and in the group taking Liv 52 - 74%. In acute liver pathologies, the use of these liver tablets aggravated the severity of the inflammatory syndrome.

As for the use of dietary supplements intended for the treatment of liver diseases, cleansing it, normalizing digestion - this remains the patient’s choice, whether he believes the manufacturer’s assurances or not. Since the safety and quality of each series of food additives can only be confirmed by the manufacturer - a “piece of paper” (quality certificate), and what will be written there and whether it corresponds to reality is on his conscience. However, there are dietary supplements whose manufacturers, taking care of product promotion, confirm their medicinal properties and positive effects on health through various laboratory and clinical studies, but there are only a few such manufacturers.

Among the dietary supplements containing extracts of medicinal herbs, one can highlight Hepatotransit, Milona 10, Ovesol, Dipana, Hepatrin.

contains aqueous extracts of 10 plants. Price: 48 pcs. 220 rub.

Liv 52 contains extracts of 7 medicinal plants. Price: 100 pcs. 200-250 rub.

contains silymarin, lecithin, vitamins E, B6, B1, B2, essential phospholipids. Price: 30 pcs. 200 rub. 60 pcs. 350 rub.

contains oat grass, agrimony, corn silk, powdered lemon juice. Price: 100 rub.

dandelion roots, burdock, elecampane, artichoke extract, corn silk. Price: 400 rub.

Composed of oat grass, turmeric, grass and roots of volodushka, sandy immortelle, peppermint. Price: 150-200 rub.

Pumpkin seed oil

Positive opinion: Pumpkin seed oil preparations contain polyunsaturated and unsaturated fatty acids with a high percentage of oleic, linoleic acids - phytosterols, vitamins C and group B, beta-carotene, essential oils, niacin, which has a hepatoprotective effect. A large amount of tocopherols and carotenoids in the composition of the preparations has an antioxidant effect, the presence of essential phospholipids slows down the process of damage to hepatocyte membranes and provides an additional membrane-stabilizing effect, accelerating the recovery of liver cells. Pumpkin seed oil (Tykveol, Peponen) is recommended for use in chronic diseases liver (hepatitis, cirrhosis).

Negative opinion: There is no evidence base regarding the clinical effectiveness of pumpkin seed oil preparations. To judge the real hepatoprotective activity of this drug, additional research is required.

Tykveol 100 ml 600 RUR, 50 drops. 260 rub.	Peponen	Pumpkin seed oil

Homeopathic medicines for the liver

Positive opinion: Among homeopathic medicines, we can highlight Hepel (Germany) and Galstena (Austria). It should be remembered that any homeopathic treatment To obtain a noticeable effect, it must be under the control of a homeopath and long enough. Monopreparations that are particularly tropic for liver cells - May celandine Chelidonium majus and milk thistle Carduus marianus, according to homeopaths, cover most of the symptoms that arise from liver diseases; they are also used as medicines that support the liver.

Negative opinion: Homeopathy has both its supporters and its ardent opponents (they consider their effectiveness to be simple). Homeopathic remedies have not undergone proper clinical studies, so there is nothing to say about the effectiveness of these drugs for the treatment of liver diseases.

In custody

Many patients consider herbal preparations and nutritional supplements absolutely by safe means and sometimes they are taken without the knowledge of the doctor and without restrictions. This big mistake. During treatment, you should tell your doctor about all dietary supplements, herbs and medications you are taking, as they may be hepatotoxic and interact with other medications you are taking.

All medicinal plants have a complex composition and contain, although minimal doses, toxic (poisonous) substances. For example, many Chinese herbs have hepatotoxic properties, leading to acute liver failure. Moreover, control over such plant products ( food additives) even in the USA, where the safety of drugs and products is strictly controlled, is not carried out to the proper extent. What can we say about Russia? Therefore, the use of any herbal remedies should be treated with caution, keeping in mind their possible hepatotoxicity.

So, drugs with proven effectiveness (in varying degrees) are considered hepatoprotectors:

• Ursodeoxycholic acid
• Amino acid preparations (ornithine aspartate, ademetionine)
• Silymarin preparations are hepatoprotectors with supposed but unproven effectiveness, used for certain conditions
• Essential phospholipids - the effectiveness of their use in capsules remains controversial; intravenous administration is more preferable

Cattle liver hydrolysates should not be used due to the potential danger to the human body. Other herbal remedies cannot yet be recommended for widespread use in chronic liver diseases, since their effectiveness has not been properly proven.

Hepatoprotectors for the liver: a list of effective and inexpensive drugs

Hepatoprotectors are drugs prescribed mainly to older patients.

Due to age-related characteristics and deterioration of digestive function, people develop polyhypovitaminosis. This affects the metabolism in the body and triggers accelerated process aging. The main goal of hepatoprotectors is to prolong a person’s youth and life.

There are about 200 varieties of the drug, each of which has its own indications and contraindications for use.

What it is?

Hepatoprotectors- a group of diverse drugs that, in domestic practice, prevent the destruction of cell membranes and stimulate the regeneration of hepatocytes, thereby having a positive effect on liver function. They increase the liver’s resistance to pathological influences, enhance its detoxification function by increasing the activity of enzyme systems (including cytochrome P450 and other microsomal enzymes), and also help restore its functions in case of various damages (including toxic ones).

At the same time, the proven clinical effectiveness of the use of hepatoprotectors for various conditions is contradictory.

Groups of hepatoprotectors

Currently, there is the following classification of tablets, when taken, the liver is supposedly restored:

• phospholipids;
• amino acid derivatives;
• medicines of animal origin;
• bile acids;
• herbal medicines;
• homeopathic medicines;
• Dietary supplements.

But no matter how much patients ask what is the most effective drug for improving the functioning, maintaining and treating the liver, there is no ideal drug that could restore liver tissue very quickly and effectively. As a rule, such medications are taken throughout the entire period as long as there is an adverse effect of a certain factor on the human liver and there is significant harm from such an effect.

At the same time, patients who need liver protection when taking antibiotics, or those who are interested in how to support the liver when taking alcohol, should understand that a one-time use of such a drug after a person has consumed alcohol, toxic drugs, or overeated, has no effect at all . Therefore, it is better not to treat the liver on your own, because a hepatoprotective agent is only an auxiliary drug in complex therapy, and it is necessary to determine which better drug and how to treat it, only a specialist should.

Organ functions and drug effects

Any disease that affects the liver causes serious disruption in almost all body systems, since the organ performs a number of important functions, in particular the liver:

• responsible for protein, carbohydrate, lipid, pigment metabolism;
• neutralizes the harmful effects of toxins and drugs;
• stores vitamins and microelements;
• produces cholesterol and lipids;
• regulates blood clotting;
• responsible for the production of bile acids and their transport to the gallbladder;
• stimulates intestinal function;
• synthesizes and inactivates some hormones, including sex hormones;
• produces enzymes;
• is a blood repository.

Nature, having endowed the liver with so many functions, took care of its integrity. This is the only organ that can recover even after partial removal. But the body cannot always cope with some factors on its own, namely:

• obesity;
• alcohol;
• medications;
• genetic factors;
• drug use;
• poor environment;
• diabetes mellitus;
• physical inactivity;
• improper nutrition.

Although the liver is capable of recovery, prolonged excessive stress sooner or later disrupts its activity. Hepatoprotectors are designed to protect the liver from such factors. They, of course, will not replace basic therapy, but will complement the effect of prescribed medications and can improve the function of liver cells.

In case of liver pathologies (hepatitis, hepatosis, fibrosis, cirrhosis, liver failure, cancer, etc.) and forced prolonged use of certain medications (anticonvulsants, antitumor, painkillers), the doctor must prescribe hepatoprotectors.

Recently, a myth has formed that this class of drugs is just an invention of “greedy” pharmacists who want to profit from the grief of patients and produce drugs with dubious effectiveness. Opponents of these drugs rely on the fact that in Europe and the USA, liver treatment is not carried out with such medications, since they do not exist in the list of pharmacological agents.

When are drugs from this group prescribed?

IN Russian pharmacies There is a wide selection of liver cleansing drugs that are very popular. The cost of the therapeutic course is expensive for patients, although not everyone feels the result. Discussions about the appropriateness and necessity of such treatment in medical circles have been going on for a long time; in our country, a doctor can prescribe hepatoprotectors in the following cases:

1. For (fatty liver). Hepatoprotectors are used as part of complex therapy, which includes: a low-fat diet, antidiabetic drugs, and regular exercise.
2. After chemotherapy. The hepatoprotective agent helps to gradually restore the liver.
3. . Medicines are prescribed if antiviral drugs do not show the expected effect or for any reason antiviral therapy is impossible.
4. When caused by alcoholism. IN in this case The main step to recovery is to stop drinking alcohol, otherwise hepatoprotectors will be absolutely useless.
5. For toxic hepatitis (after taking antibiotics). Hepatoprotectors are effective in combination with other drugs to restore the liver, diet, and giving up bad habits.
6. With enlarged liver (hepatomegaly). For rapid regeneration of organ cells and normal functioning of the organ, hepatoprotectors are used.

List of popular hepatoprotectors for 2019

The list of hepatoprotectors with proven effectiveness for 2019 is not that long. First of all, it is ursodeoxycholic acid, as well as amino acids. However, the effect of amino acids in most cases manifests itself only with injections, and ursodeoxycholic acid is used for liver diseases to treat only certain manifestations and cannot be considered as a universal drug.

List of inexpensive and effective hepatoprotectors:

A drug	Price from
Berlition	594 rub.
	461 rub.
Hepa-merz	769 rub.
Hepatrin	320 rub.
Heptor	1022 rub.
Heptral	1612 rub.
Karsil	372 rub.
Legalon	283 rub.
Ovesol	172 rub.
Octolipen	359 rub.
Rezalut Pro	1332 rub.
Thiogamma	223 rub.
Tykveol	278 rub.
Urdoxa	741 rub.
Ursosan	191 rub.
Ursofalk	210 rub.
Phosphogliv	540 rub.
Hepel	366 rub.
Hofitol	372 rub.
Essentiale Forte	715 rub.
Essliver	315 rub.

Classification of liver drugs by type of active substances:

Active Ingredients	Drugs
Animal liver cells	Hepatosan, Sirepar, Progepar
Milk Thistle Extract (Silymarin)	Karsil, Gepabene, Galstena, Legalon, Fosfontziale, Gepatrin, Livesil Forte
Artichoke extract	Hofitol, Gepatrin
Pumpkin seed extract	Tykveol, Peponen
Other herbal ingredients	Hepel, Liv 52, Ovesol
Phospholipids	Essentiale Forte, Phosphogliv, Antraliv, Essliver, Phosphonciale, Rezalut Pro, Hepatrin, Livesil Forte
Ursodeoxycholic acid	Ursofalk, Urdoxa, Ursosan, Livodexa
Thioctic acid	Octolipen, Thiogamma, Berlition
Ademetionine	Heptral, Heptor
Ornithine	Hepa-Merz

Hepatoprotectors with essential phospholipids

According to statistics, these drugs are most common in post-Soviet regions. They are obtained from soybeans. Phospholipids are products of lipid metabolism, which are kind of building blocks for the construction of cells. These substances are involved in the transport of nutrients, cell division and differentiation, and they activate various enzymatic systems.

The advantages of hepatoprotectors based on essential phospholipids include:

• the ability to quickly restore hepatocytes at the molecular level;
• protection against toxins and viruses;
• improvement of the action of interferons;
• preventing the formation of scar tissue.

However, there are also negative opinions about these medications.. In particular, in 2003, a study was conducted in the United States that did not determine the positive effect of such drugs on liver function. Scientists have also found that during the treatment of hepatitis - acute and chronic, inflammation intensified, since drugs in this group do not have choleretic properties, and the bile stagnates.

If we are guided by these studies, then the choice of drugs of this type for the treatment of viral hepatitis is the wrong decision. There is also evidence that different B vitamins, which are present, for example, in Essliver Forte, are not recommended to be taken at the same time. Some sources claim that tablets like Essentiale practically do not enter the liver, being distributed throughout the body. It is advisable to take B vitamins separately in tablets; the names of the drugs can be obtained from your doctor.

Therefore, treatment of liver disease with such drugs may be ineffective. At the same time, the price of hepoprotective drugs is quite high: if you take capsules for one month, the cost of treatment will be approximately 3,000 rubles. Thus, taking modern means of this type, the patient receives questionable effectiveness. And people with hepatitis (the active form of the disease) need to take them very carefully.

List of essential phospholipids:

Essentiale N, Essentiale forte N Composition: essential phospholipids. Side effects: well tolerated, sometimes diarrhea and abdominal discomfort are possible. Contraindicated in children under 12 years of age. Average price in pharmacies 2018: 30 pcs. 660 RUR, 5 amp. 950 rub. 90 pcs. 1300 rub.

Essliver Forte Ingredients: essential phospholipids (less than in Essential), vitamins (B1, B2, B6, E, PP, B12) Side effects: possible diarrhea, pain in the upper abdomen With caution for children under 1 2 years old, pregnant and lactating women. Price: 30 caps. 300 rub, 50 caps. 420 rub.

Fosphonziale Ingredients: Lipoid C100 and Silymarin Price: 30 caps. 420-480 rub.

Gepagard Active Ingredients: essential phospholipids, vitamin E Price: 30 caps. 300 rubles, 120 drops.. 900-950 rubles.

Phosphogliv Ingredients: phospholipids, trisodium salt of glycyrrhizic acid (antiviral and immunomodulatory effects) Price: 50 caps. 450-500 rub. powder for injection 5 pcs. 1300-1500 rub.

Rezalut PRO Composition: Lipoid PPL 600, which contains: medium chain triglycerides, phospholipids, glycerol mono/dialconate, soybean oil, vitamin E. Price: 30 caps. 450 rub., 100 caps. 1300 rub.

Doppelhertz active essential phospholipids Compound: Essential phospholipids, Vitamin B1, B2, B6 Price: 60 caps. 460 RUR, 5 amp. 640 rub.

Eslidin Composition: phospholipids + methionine Indicated: For liver diseases, diabetes mellitus, psoriasis, dystrophy and exhaustion, atherosclerosis of the coronary arteries and cerebral vessels . Contraindicated: children under 3 years of age, pregnant and lactating women with caution. Price: 580 -720 rub.

Hepatoprotectors with components of animal origin

Preparations created from pork liver are capable of regenerating hepatocytes of the human liver, since they are as similar in composition as possible. Thanks to their detoxification and antioxidant effects, they treat hepatitis, hepatosis and cirrhosis of the liver.

Among the positive qualities noted:

• the ability to remove toxins from the body;
• accelerate the regeneration of hepatocytes;
• restore lost liver functions.

• high risk of allergies;
• the risk of developing immunopathological syndromes in acute forms of hepatitis;
• they are not suitable for the prevention of liver diseases.

Cons: There is no clinical evidence that the medicine actually helps or is safe. There is also a potential danger when taking these medications: for example, they should not be taken if you have active hepatitis. Also, drugs of this type have a high allergenic potential. Therefore, before practicing such treatment, it is necessary to determine whether the person has high sensitivity to the drug.

When taking such drugs, there is a risk of the patient contracting a prion infection, which causes spongiform encephalopathy. Therefore, when determining which medicine is better, you need to take into account that there is an opinion that it is not advisable to take these tablets for the treatment of liver pathologies.

Hepatoprotectors with amino acids: Heptral, Heptor (Ademethionine)

Positive opinion- amino acids, for example, ademetionine, take part in the synthesis of biologically active substances and phospholipids, and have regenerating and detoxifying properties. By the end of 1 week of use, Heptral also exhibits a pronounced antidepressant effect, breaks down fats and promotes their removal from the liver. These medications are used for fatty liver hepatosis (fatty degeneration), chronic hepatitis, toxic hepatitis, withdrawal syndrome, and depression.

Analysis of clinical studies conducted indicates the clinical effectiveness of ademetionine and indicates a pronounced hepatoprotective effectiveness in alcohol and drug-induced liver damage, cholestatic liver diseases (primary biliary cirrhosis), and chronic viral hepatitis. It has choleretic and cholekinetic effects, antioxidant, neuroprotective and antifibrosing properties.

Negative opinion— Heptral is a registered drug in Russia, Germany and Italy. Also in Australia he is veterinary drug(for dogs and other animals). In all other countries, the drug is positioned as a dietary supplement, since research results have shown dubious results.

Most doctors still claim the effectiveness of this drug, but only if it is infused intravenously, since it is poorly absorbed when taken orally.

Ornithine aspartate - Hepa-Merz

Positive opinion— Ornithine helps reduce high levels of ammonia, is used for disorders of the brain associated with impaired liver function, as well as for fatty degeneration and toxic hepatitis. This medicine is practically not used for prevention.

The effectiveness of Hepa-Merz was proven in a randomized multicenter study in patients with liver cirrhosis with elevated levels of ammonia in the blood. It is prescribed for various types of hepatitis, non-alcoholic steatohepatitis, especially for hepatic encephalopathy and cirrhosis of the liver.

Negative opinion- in the case of alcoholic liver damage, it has practically no effect, so supporting and protecting the liver with this remedy is ineffective. A noticeable effect is observed only in hepatic coma. It is advisable to use the drug for the purpose of short-term recovery from this state.

Hepatoprotectors of plant origin

Herbal-based preparations have won the greatest confidence. Especially popular are the fruits of milk thistle, which contain many biologically active components (microelements, vitamins, organic acids).

Preparations based on milk thistle significantly reduce the toxic effect on the liver and promote the regeneration of cellular structures. In damaged hepatocytes, protein production is stimulated, cell membranes are stabilized, and the loss of trace elements stops, thereby increasing the natural regeneration of liver cells.

However, there is insufficient confirmed data on the clinical effectiveness of silymarin in the treatment of alcoholic liver tissue damage. Effectiveness in acute hepatitis C and viral hepatitis B has not been proven. In the future, studies will be conducted on the effectiveness of silymarin in the treatment of chronic liver diseases.

Karsil and Karsil Forte Ingredients: milk thistle extract. Application: before meals, with a sufficient amount of water, course for at least 3 months. For prevention, 1 tablet 3 times a day. For children over 12 years of age and adults with severe liver damage, 4 dr. 3 times a day, then 1-2 dr. 3 times a day. Side effects Karsil 80 pcs. 330 rub., Karsil Forte 30 pcs. 380 rub.

Legalon Ingredients: milk thistle fruit extract. Application: after eating, without chewing, with a small amount of liquid. Start of treatment 2 caps. 3 r/day, maintenance therapy 1 dr. 3 r/day. Side effects: allergic reactions, diarrhea. Legalon 70 mg: 30 caps. 230 rub. 60 caps. 400 rub Legalon 140 mg: 30 caps - 340 rubles, 60 caps. 600 rub.

Gepabene (milk thistle and smokeweed) Ingredients: herbal fumifera dry extract and milk thistle. Contraindication: children under 18 years of age, acute inflammation of the liver and biliary tract. Application: 1 capsule. 3 times a day For pain, take an additional 1 capsule. before bedtime. The maximum daily dose is 6 capsules, taken in 3-4 divided doses. Price: 30 caps. 430-570 rub.

Silymar tablets Ingredients: milk thistle fruit extract. Application: for toxic liver damage, cirrhosis, after hepatitis, chronic hepatitis, for long-term use of alcohol and medications, for intoxication. 1-2 tablets each. 3 times a day for 30 minutes. before meals. Course 25-30 days. After 1-3 months, you can repeat the treatment. Not recommended children under 12 years old. Side effects: possible loose stools and allergic reactions. Price: 30 pcs. 110-150 rub.

Milk thistle tablets (extract) Ingredients: 50 mg silymarin. Application, indications, contraindications and side effects the same as for other preparations with milk thistle extract. Price: 20 pcs. 130 rub.

Milk thistle meal (crushed plant) Application: 1 teaspoon 3 times a day with meals. Contraindications: cholelithiasis, exacerbation of gastric and duodenal ulcers, hypersensitivity, pregnant and lactating women. Side effects: pain in the right hypochondrium, diarrhea, allergies. Price: 60 rub.

Milk thistle oil in capsules Application: adults, 1 capsule. 2 times a day during meals. The course is 1 month, which can be repeated 2-3 times a year. Contraindications: acute gastrointestinal diseases, childhood. Price: 40-60 rub.

Milk thistle syrup Ingredients: milk thistle meal and extract, common thyme herb, tansy flowers. Application: 1 tbsp. spoon 1-2 times a day during meals. Course 4-6 weeks. It is possible to repeat the course up to 4 times a year. Contraindications: children under 14 years of age, pregnancy, lactation, diabetes. Price: 150 ml. 110 rub.

Milk thistle tablets are not the only herbal medicines that restore and protect the liver. Celandine, artichoke, turmeric, pumpkin seeds, and fumaria officinalis can act as active ingredients in a number of hepatoprotectors. They are distinguished by a minimal number of side effects, the ability to eliminate spasms of the gallbladder, and improve the outflow and production of bile. For example, Allochol, which is not a hepatoprotector, also consists of plant components, but causes a lot of side effects.

At the same time, medical data indicate that artichoke leaf extract is widely used, but at the same time, what it can do is effective assistance, not clinically proven. It is not recommended to use for cholelithiasis, acute hepatitis, cholestasis syndrome.

The list of popular drugs includes:

• Liv-52, regenerating damaged intracellular processes. Prescribed for persistent disturbances of appetite, it has a healing effect on the liver due to its powerful phytocomposition.
• Pumpkin based on pumpkin seed oil. It has a pronounced antioxidant and hepatoprotective effect, normalizes the composition of bile and the condition of the bile ducts.
• Chophytol, which has a choleretic and diuretic effect, improves blood composition and promotes the rapid elimination of urea.
• Hepel, which has antispasmodic, choleretic, hepatoprotective, antidiarrheal, and anti-inflammatory effects.

Dietary supplements or homeopathic medicines

List of drugs:

1. Galstena with active plant components - milk thistle, medicinal dandelion and celandine. The drug also contains phosphorus and sodium sulfate. Prescribed for the treatment of liver pathologies occurring in acute and chronic forms, in case of impaired functioning of the gallbladder, chronic pancreatitis.

The medicine is taken after meals or 1 hour before meals. Children under one year old are prescribed ½ tablet 3 times a day, children 1-12 years old - ½ tablet (or 5 drops of the drug), children over 12 years old and adults - 1 tablet. In severe forms of the disease, the frequency of taking the drug is increased to 8 times a day.

1. Hepel. The medicine contains spotted milk thistle, components of the quinn tree, celandine, nutmeg, phosphorus and colocynth. It has anti-inflammatory, analgesic, choleretic and antidiarrheal properties. Prescribed to patients suffering from bloating, appetite disorders, eczema, acne on the body, as well as toxic and inflammatory liver diseases. Hepel is taken three times a day, one tablet. In severe forms of pathology, patients are administered 1 ampoule of the drug intramuscularly.